GO:0007168

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Name receptor guanylyl cyclase signaling pathway
Categary Process
Go Slim No
Go Link GO:0007168
Unique Molecular Interactions 331
Total Molecular Interactions 502
Total Single Events 5301
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for receptor guanylyl cyclase signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for receptor guanylyl cyclase signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
2 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
3 INT111787 Cck Regulation of Gene_expression of Npr1 1 0.22 1.68 2.57
4 INT107812 Nppa Positive_regulation of Localization of Sst 1 0.48 0.54 2.51
5 INT240131 Binding of Crp and Nppb 7 0.07 11.53 2.12
6 INT33756 Akr1d1 Positive_regulation of Npr1 3 0.01 0 2.05
7 INT21261 Penk Negative_regulation of Npr1 1 0.02 0 2
8 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
9 INT68709 Positive_regulation of Crh Regulation of Npr1 1 0.03 0 1.71
10 INT68710 Crh Regulation of Npr1 1 0.03 0 1.7
11 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
12 INT144213 Nppa Positive_regulation of Localization of Calca 1 0.71 2.8 1.65
13 INT33757 Hmmr Positive_regulation of Npr1 1 0.01 0 1.59
14 INT107815 Gene_expression of Sst Positive_regulation of Localization of Nppa 1 0.52 0.27 1.57
15 INT107813 Sst Negative_regulation of Localization of Nppa 1 0.44 0.2 1.46
16 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45
17 INT6466 Binding of Npr1 and Oprd1 1 0.01 0 1.37
18 INT31772 Ednra Positive_regulation of Nppa 1 0.05 0.13 1.33
19 INT31771 Penk Positive_regulation of Nppa 1 0.22 0.13 1.28
20 INT31773 Pdyn Positive_regulation of Nppa 1 0.12 0.13 1.27
21 INT143620 Ltp Positive_regulation of Npr1 1 0.01 0.16 1.26
22 INT42554 Oprl1 Regulation of Npr1 2 0.06 0 1.22
23 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
24 INT13205 Oprd1 Negative_regulation of Npr1 2 0.01 0 1.16
25 INT13204 Binding of Npr1 and Akr1d1 1 0.00 0 1.14
26 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
27 INT33142 Pck1 Positive_regulation of Npr1 4 0.01 0.5 1.02
28 INT13502 Penk Positive_regulation of Npr1 1 0.02 0.19 1.01
29 INT13503 Regulation of Penk Positive_regulation of Npr1 1 0.02 0.19 1.01
30 INT7025 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.08 1.01
31 INT42555 Oprl1 Negative_regulation of Npr1 1 0.02 0 0.99
32 INT28194 Nppb Positive_regulation of CYP2B6 1 0.50 0.05 0.88
33 INT28193 Nppb Positive_regulation of Positive_regulation of RYBP 1 0.29 0.05 0.88
34 INT111790 Penk Regulation of Gene_expression of Npr1 1 0.22 0.56 0.86
35 INT41156 Sst Negative_regulation of Npr1 1 0.05 0 0.84
36 INT29781 PDYN Negative_regulation of Npr1 1 0.00 0.22 0.84
37 INT298457 Binding of Calca and Npr1 1 0.01 0.39 0.77
38 INT166902 NPPB Positive_regulation of TRPA1 1 0.78 0.76 0.77
39 INT107810 Sst Positive_regulation of Localization of Nppa 1 0.42 0.14 0.77
40 INT21260 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.05 0 0.76
41 INT147619 Npr1 Positive_regulation of Localization of Calca 1 0.03 0 0.75
42 INT57658 ASNA1 Positive_regulation of Npr1 1 0.00 0.15 0.74
43 INT169603 Nppb Regulation of Npr1 1 0.26 0.95 0.69
44 INT71988 Drd1a Regulation of Npr1 1 0.10 0 0.68
45 INT111555 Negative_regulation of Npr1 Negative_regulation of Positive_regulation of Creb1 1 0.02 0.58 0.66
46 INT6464 Sst Regulation of Negative_regulation of Npr1 1 0.01 0 0.64
47 INT6463 Oprd1 Regulation of Negative_regulation of Npr1 1 0.01 0 0.63
48 INT6465 Trh Regulation of Negative_regulation of Npr1 1 0.01 0 0.63
49 INT16412 Nppa Negative_regulation of Localization of LH 2 0.41 0.29 0.62
50 INT147049 CB Positive_regulation of Nppa 1 0.02 1.01 0.6
51 INT101216 Pnoc Positive_regulation of Localization of Nppa 1 0.68 0.09 0.57
52 INT147040 Hmbs Negative_regulation of Nppa 1 0.07 0.95 0.55
53 INT107814 Nppa Positive_regulation of Positive_regulation of Sst 1 0.42 0.16 0.55
54 INT16643 Nppa Regulation of Rabep2 1 0.13 0.07 0.55
55 INT43075 Slc6a14 Regulation of Positive_regulation of Npr1 1 0.01 0 0.51
56 INT43076 Slc6a14 Regulation of Npr1 1 0.01 0 0.51
57 INT7120 Nppb Positive_regulation of Localization of Rab8a 1 0.08 0 0.51
58 INT55265 Ptgdr Negative_regulation of Npr1 1 0.01 0 0.46
59 INT16413 Nppa Regulation of Localization of LH 1 0.43 0.76 0.45
60 INT52679 Positive_regulation of Npr1 Positive_regulation of Positive_regulation of VSX1 1 0.00 0 0.45
61 INT25430 Gtf3a Regulation of Nppa 1 0.24 0.57 0.43
62 INT170157 NPPC Regulation of CSF2 1 0.12 1.36 0.42
63 INT79486 Nppa Negative_regulation of NA 1 0.03 1.83 0.41
64 INT16411 Nppb Regulation of Localization of LH 1 0.34 0.49 0.41
65 INT131353 Binding of Npr1 and Nppb 1 0.27 1.73 0.4
66 INT131356 Binding of Nppa and Npr1 1 0.27 1.73 0.4
67 INT57649 Oprd1 Positive_regulation of Npr1 1 0.01 0.1 0.39
68 INT95999 Binding of Npr1 and Cnr1 1 0.05 0 0.39
69 INT71575 Negative_regulation of Nppb Positive_regulation of Gbf1 1 0.02 0.08 0.38
70 INT71574 Nppb Positive_regulation of Gbf1 1 0.02 0.08 0.38
71 INT16410 Nppb Negative_regulation of Localization of LH 1 0.37 0.21 0.38
72 INT169604 Nppb Positive_regulation of Npr1 2 0.52 2.52 0.37
73 INT154356 Binding of Nppc and ITS 1 0.00 0.85 0.35
74 INT32698 Nppa Regulation of Oxt 1 0.57 0.35 0.35
75 INT32699 Nppa Regulation of Avp 1 0.28 0.35 0.35
76 INT240129 Binding of Nppb and Crp 1 0.21 1.02 0.32
77 INT115261 Gene_expression of Nos2 Positive_regulation of Positive_regulation of Npr1 1 0.05 0.67 0.31
78 INT166901 NPPB Positive_regulation of Gene_expression of TRPA1 1 0.68 0.33 0.3
79 INT147041 Hmbs Negative_regulation of Negative_regulation of Nppa 1 0.05 0.51 0.3
80 INT30706 Nppa Positive_regulation of Localization of AVP 1 0.78 0.45 0.3
81 INT96436 Binding of Npr1 and Oprl1 1 0.05 0 0.29
82 INT136245 Gucy1a2 Positive_regulation of Nppa 1 0.06 0.22 0.27
83 INT208499 Positive_regulation of Nkx1-1 Positive_regulation of Npr1 1 0.00 0 0.27
84 INT149358 Binding of Oprm1 and Positive_regulation of Positive_regulation of Npr1 1 0.00 0.09 0.26
85 INT136246 Gucy1a2 Negative_regulation of Nppa 1 0.05 0.22 0.26
86 INT20587 Nppa Positive_regulation of Gfra1 1 0.02 0.32 0.26
87 INT47012 Regulation of Pck1 Positive_regulation of Npr1 1 0.01 0 0.26
88 INT32636 Slc12a3 Regulation of Localization of Nppa 1 0.00 0.41 0.23
89 INT170158 NPPA Positive_regulation of Gene_expression of NPPB 1 0.13 0.91 0.23
90 INT146993 Binding of NPPA and NPPC 1 0.27 0.82 0.22
91 INT32565 Nppa Regulation of Localization of CGA 1 0.00 0.07 0.22
92 INT131355 Npr1 Regulation of Nppb 1 0.39 0.88 0.22
93 INT131354 Npr1 Regulation of Nppa 1 0.40 0.88 0.22
94 INT25089 Glul Positive_regulation of Npr1 1 0.00 0 0.2
95 INT21171 Nppa Regulation of Ren 1 0.35 0.35 0.19
96 INT32700 Nppa Negative_regulation of Oxt 1 0.40 0.16 0.19
97 INT32696 Nppa Negative_regulation of Avp 1 0.45 0.16 0.19
98 INT32697 Nppa Negative_regulation of Gene_expression of Oxt 1 0.40 0.16 0.19
99 INT32494 Nppa Negative_regulation of Localization of Avp 1 0.28 1.16 0.18
100 INT154355 Binding of Nppc and Npr1 1 0.19 0.43 0.18
101 INT29959 Ahsp Positive_regulation of Npr1 1 0.00 0.18 0.17
102 INT33141 Pck1 Regulation of Npr1 1 0.00 0.17 0.16
103 INT26367 POMC Regulation of Localization of NPPA 1 0.28 0.29 0.16
104 INT310595 Ros1 Positive_regulation of Npr1 1 0.03 0.84 0.16
105 INT30705 Nppa Negative_regulation of Localization of AVP 1 0.48 0.22 0.15
106 INT251435 Gnat3 Positive_regulation of NPR1 1 0.22 0.2 0.15
107 INT7296 Binding of HCLS1 and NPPA 1 0.02 1.65 0.15
108 INT56181 sch Regulation of Positive_regulation of Nppa 1 0.07 0.08 0.14
109 INT109082 Adra2a Regulation of Nppa 1 0.21 0.56 0.14
110 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12
111 INT170159 Negative_regulation of NPPC Regulation of CSF2 1 0.20 0.33 0.11
112 INT71755 Nppa Regulation of Localization of Alb 1 0.25 1.29 0.11
113 INT7302 Binding of NPPA and Nppa 1 0.13 1.25 0.11
114 INT42154 NPPA Regulation of Gene_expression of TUBA4A 1 0.04 0.68 0.1
115 INT25090 Negative_regulation of Glul Positive_regulation of Npr1 1 0.00 0 0.1
116 INT43284 Binding of Npr1 and Gcg 1 0.05 0 0.1
117 INT10906 Agt Regulation of Localization of Nppb 1 0.10 0.19 0.1
118 INT5627 Tfpi Positive_regulation of Localization of Nppa 1 0.31 0.07 0.1
119 INT42153 NPPA Regulation of TUBA4A 1 0.04 0.68 0.1
120 INT164428 Gsta3 Positive_regulation of Npr1 1 0.00 0 0.1
121 INT5626 Tfpi Positive_regulation of Transcription of Nppa 1 0.31 0.07 0.1
122 INT10904 Edn1 Regulation of Localization of Nppb 1 0.22 0.54 0.1
123 INT46240 Npr1 Positive_regulation of Localization of Avp 1 0.05 0 0.09
124 INT7295 HCLS1 Positive_regulation of NPPA 1 0.02 0.44 0.09
125 INT9086 Binding of Nppa and Nppb 1 0.35 0.19 0.08
126 INT208937 Nfkb1 Positive_regulation of Gene_expression of Nppa 1 0.04 0.38 0.08
127 INT25269 Hmmr Negative_regulation of Npr1 1 0.01 0.63 0.08
128 INT91097 Ptprg Positive_regulation of Npr1 1 0.00 0.62 0.08
129 INT257226 Phosphorylation of Prkacb Positive_regulation of Npr1 1 0.00 0 0.08
130 INT222489 Npr2 Positive_regulation of Pde5a 1 0.00 0.16 0.07
131 INT50079 Binding of NPPA and SLC12A1 1 0.01 0.42 0.07
132 INT51719 Nppa Regulation of Regulation of Pomc 1 0.14 0.1 0.07
133 INT146721 Nppc Positive_regulation of Positive_regulation of Oprl1 1 0.16 0.34 0.07
134 INT50078 Binding of APOE and NPPA 1 0.30 0.42 0.07
135 INT91098 Gcgr Positive_regulation of Npr1 1 0.01 0.38 0.06
136 INT16414 Nppa Regulation of Nppb 1 0.24 0.26 0.05
137 INT43283 Gcg Positive_regulation of Npr1 1 0.07 0 0.05
138 INT222512 Nppa Positive_regulation of Localization of LH 1 0.02 0 0.05
139 INT208945 Nkx2-5 Positive_regulation of Gene_expression of Nppa 1 0.03 0.33 0.05
140 INT171399 Binding of Npr1 and Prkcg 1 0.00 0.23 0.04
141 INT171401 Binding of Adcyap1 and Npr1 1 0.02 0.23 0.04
142 INT239402 Binding of NPPA and ASAP1 1 0.19 1.24 0.04
143 INT158391 Oxt Positive_regulation of Localization of Nppa 2 0.27 0.64 0.03
144 INT44815 Sct Positive_regulation of Npr1 1 0.06 0 0.03
145 INT325600 Nppa Positive_regulation of Pde2a 1 0.11 0.16 0.03
146 INT325586 Nppa Positive_regulation of Prkg1 1 0.28 0.16 0.03
147 INT177671 Vmn1r51 Positive_regulation of Localization of Nppa 1 0.01 0.24 0.03
148 INT253085 NPPA Positive_regulation of INS 1 0.32 0 0
149 INT10901 Edn1 Positive_regulation of Localization of Nppb 1 0.39 0.68 0
150 INT10903 Apoa2 Positive_regulation of Nppb 1 0.08 0.17 0
151 INT10909 Edn1 Positive_regulation of Nppb 1 0.39 0.16 0
152 INT325589 Nppa Regulation of Cacna1c 1 0.05 0 0
153 INT14790 Nppa Regulation of Edn3 1 0.45 0.7 0
154 INT325595 Nppa Negative_regulation of Ang 1 0.25 0.46 0
155 INT10907 Apoa2 Positive_regulation of Localization of Nppb 1 0.09 0.23 0
156 INT14792 Edn3 Regulation of Nppa 1 0.17 0.17 0
157 INT239401 FIG4 Regulation of NPPA 1 0.17 2.24 0
158 INT256210 NPPB Regulation of PVR 1 0.24 1.14 0
159 INT325587 Binding of Ang and Nppa 1 0.21 0.24 0
160 INT354619 AR Positive_regulation of Gene_expression of Nppa 1 0.00 0.38 0
161 INT165146 Kiss1 Regulation of Nppa 1 0.42 0 0
162 INT325606 Negative_regulation of Nppa Negative_regulation of Ang 1 0.25 0.46 0
163 INT213049 Hdl1 Regulation of Gene_expression of Nppc 1 0.09 1 0
164 INT325597 Nppa Regulation of Gopc 1 0.15 0 0
165 INT91095 Naf1 Positive_regulation of Npr1 1 0.01 0.18 0
166 INT325605 Pls1 Regulation of Nppa 1 0.00 0 0
167 INT325593 Pde2a Positive_regulation of Negative_regulation of Nppa 1 0.11 0 0
168 INT191984 Ide Positive_regulation of Nppc 1 0.04 0.13 0
169 INT11122 Nppa Negative_regulation of Thop1 1 0.20 0.4 0
170 INT325588 Nppa Regulation of Localization of Rgs2 1 0.32 0 0
171 INT247031 Npr1 Positive_regulation of Prkaca 1 0.00 0 0
172 INT325604 Nppa Regulation of Car2 1 0.23 0 0
173 INT325584 Binding of Olfml3 and Nppa 1 0.01 0.1 0
174 INT10908 Avp Positive_regulation of Localization of Nppb 1 0.42 0.23 0
175 INT91096 Naf1 Positive_regulation of Binding of Npr1 1 0.02 0.19 0
176 INT256211 NPPB Regulation of PDAP1 1 0.28 1.14 0
177 INT325611 Nppa Regulation of Gene_expression of Car2 1 0.20 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for receptor guanylyl cyclase signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in receptor guanylyl cyclase signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78
2 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11
3 INT5617 Localization of Nppa 266 0.81 83.51 83.89
4 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33
5 INT5620 Positive_regulation of Localization of Nppa 105 0.70 30.23 36.45
6 INT6196 Regulation of Nppa 83 0.62 30.31 30.18
7 INT8205 Negative_regulation of Nppa 77 0.59 26.43 25.72
8 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31
9 INT7017 Regulation of Npr1 45 0.52 3.38 20.05
10 INT4260 Negative_regulation of Positive_regulation of Npr1 29 0.43 4.39 19.57
11 INT6461 Gene_expression of Npr1 35 0.75 10.38 17.58
12 INT5618 Regulation of Localization of Nppa 36 0.62 13.42 17.46
13 INT9299 Positive_regulation of Positive_regulation of Npr1 32 0.53 6.65 16.72
14 INT8989 Binding of Npr1 25 0.36 5.52 14.58
15 INT14764 Negative_regulation of Localization of Nppa 28 0.59 11.29 12.82
16 INT9083 Gene_expression of Nppb 74 0.78 70.96 12.19
17 INT11121 Positive_regulation of NPPA 64 0.70 34.09 11.96
18 INT9084 Positive_regulation of Nppb 74 0.70 69.77 11.85
19 INT7132 Localization of NPPA 53 0.81 19.79 10.86
20 INT13606 Negative_regulation of Negative_regulation of Npr1 13 0.40 1.21 10.01
21 INT16356 Regulation of NPPA 33 0.62 13.24 9.53
22 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81
23 INT26487 Positive_regulation of Npr1 17 0.70 10.01 8.78
24 INT6210 Binding of Nppa 39 0.47 14.35 7.21
25 INT15156 Positive_regulation of Localization of NPPA 21 0.70 8.61 6.97
26 INT26489 Negative_regulation of Npr1 15 0.59 5.7 6.79
27 INT6565 Positive_regulation of Positive_regulation of Nppa 14 0.70 4.04 6.76
28 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54
29 INT6459 Regulation of Negative_regulation of Npr1 10 0.53 0.16 6.44
30 INT7021 Positive_regulation of Negative_regulation of Npr1 8 0.22 1.02 6.36
31 INT6195 Transcription of Npr1 9 0.69 3 5.94
32 INT7018 Positive_regulation of Gene_expression of Npr1 10 0.59 5.09 5.66
33 INT13706 Localization of Npr1 10 0.59 0.83 5.42
34 INT11064 Positive_regulation of NPR1 24 0.49 14.63 4.78
35 INT7298 Gene_expression of NPPA 35 0.70 18.23 4.76
36 INT5624 Transcription of Nppa 19 0.69 8.52 4.72
37 INT45159 Regulation of Nppb 16 0.54 13.57 4.46
38 INT5619 Positive_regulation of Gene_expression of Nppa 21 0.70 11.95 4.41
39 INT73434 Negative_regulation of Nppa 8 0.35 3.86 4.31
40 INT16408 Negative_regulation of Nppb 14 0.53 5.49 3.74
41 INT159472 Localization of NPPB 32 0.79 33.67 3.59
42 INT9085 Localization of Nppb 32 0.81 15.1 3.47
43 INT240127 Binding of Nppb 19 0.37 22.42 3.3
44 INT16357 Negative_regulation of NPPA 23 0.58 12.37 2.98
45 INT6193 Regulation of Gene_expression of Nppa 6 0.45 2.02 2.93
46 INT54449 Positive_regulation of Transcription of Npr1 3 0.45 1.73 2.81
47 INT99104 Gene_expression of Npr1 5 0.78 3.31 2.8
48 INT26205 Positive_regulation of Positive_regulation of NPR1 3 0.24 1.57 2.52
49 INT20498 Negative_regulation of Positive_regulation of Nppa 9 0.59 4.5 2.43
50 INT11065 Gene_expression of NPR1 6 0.55 3.41 2.32
51 INT120752 Positive_regulation of Gene_expression of NPPB 17 0.67 16.4 2.21
52 INT6460 Regulation of Gene_expression of Npr1 4 0.52 2.19 2.13
53 INT25461 Negative_regulation of Regulation of Nppa 2 0.43 0.22 1.97
54 INT84264 Regulation of NPPB 22 0.61 21.18 1.94
55 INT183450 Positive_regulation of GUCY2C 6 0.04 4.45 1.88
56 INT26370 Positive_regulation of Positive_regulation of NPPA 4 0.60 0.67 1.87
57 INT14413 Regulation of Positive_regulation of Npr1 7 0.62 0.71 1.78
58 INT11098 Regulation of NPR1 5 0.37 1.39 1.74
59 INT15155 Regulation of Localization of NPPA 8 0.62 2.67 1.65
60 INT43045 Negative_regulation of Regulation of Npr1 3 0.12 0.17 1.65
61 INT26488 Regulation of Npr1 4 0.39 0.88 1.56
62 INT31921 Negative_regulation of Localization of Npr1 2 0.17 0 1.51
63 INT11057 Protein_catabolism of Nppa 11 0.94 3.34 1.47
64 INT6194 Regulation of Transcription of Npr1 2 0.05 0.08 1.46
65 INT67465 Positive_regulation of Regulation of Npr1 1 0.05 0.14 1.4
66 INT73432 Gene_expression of Nppa 32 0.59 21.04 1.39
67 INT78355 Negative_regulation of Gene_expression of Npr1 2 0.06 0.15 1.22
68 INT11099 Localization of NPR1 5 0.67 1.49 1.21
69 INT89756 Positive_regulation of Positive_regulation of Npr1 2 0.47 0.9 1.19
70 INT40170 Regulation of Localization of Npr1 2 0.05 0.12 1.16
71 INT81136 Binding of Npr1 6 0.48 1.45 1.15
72 INT131351 Positive_regulation of Gene_expression of Nppb 2 0.50 13.72 1.14
73 INT133846 Binding of NPPB 14 0.42 11.52 0.98
74 INT11100 Positive_regulation of Gene_expression of NPR1 2 0.37 1.49 0.98
75 INT16371 Positive_regulation of Gene_expression of NPPA 7 0.45 3.62 0.96
76 INT23921 Negative_regulation of NPPB 13 0.58 16.19 0.9
77 INT29759 Negative_regulation of Negative_regulation of Nppa 3 0.58 1.5 0.9
78 INT11066 Negative_regulation of NPR1 5 0.27 0.89 0.88
79 INT72715 Positive_regulation of Nppc 4 0.39 1.55 0.87
80 INT15587 Protein_catabolism of NPPA 4 0.71 1.55 0.87
81 INT16587 Regulation of Negative_regulation of Nppa 3 0.53 0.84 0.82
82 INT42356 Negative_regulation of Binding of Npr1 1 0.32 0.37 0.82
83 INT32513 Regulation of Localization of NPR1 3 0.36 0.84 0.81
84 INT7297 Binding of NPPA 8 0.45 5.33 0.79
85 INT80118 Gene_expression of NPPC 2 0.68 4.14 0.77
86 INT16537 Regulation of Positive_regulation of Nppa 2 0.45 1.44 0.76
87 INT5621 Positive_regulation of Transcription of Nppa 5 0.50 4.97 0.74
88 INT19316 Positive_regulation of Localization of Nppb 2 0.50 3.15 0.73
89 INT54452 Regulation of Regulation of Npr1 1 0.03 0 0.72
90 INT5569 Phosphorylation of Npr1 3 0.18 0.61 0.7
91 INT70530 Binding of NPR1 3 0.17 0.71 0.65
92 INT54167 Negative_regulation of Positive_regulation of NPPA 4 0.42 1.26 0.63
93 INT109081 Localization of Nppa 9 0.59 2.72 0.61
94 INT254132 Positive_regulation of Localization of NPPB 2 0.40 2.9 0.58
95 INT51718 Positive_regulation of Negative_regulation of Nppa 3 0.47 0.79 0.57
96 INT89855 Localization of Npr1 1 0.20 0.32 0.57
97 INT7293 Negative_regulation of Binding of Nppa 5 0.43 1.4 0.55
98 INT183375 Binding of Nppa 14 0.38 8.95 0.51
99 INT70532 Regulation of Regulation of NPR1 1 0.12 0.31 0.49
100 INT19315 Phosphorylation of Nppb 2 0.55 0.23 0.47
101 INT5625 Regulation of Transcription of Nppa 2 0.26 0.29 0.46
102 INT19317 Regulation of Localization of Nppb 1 0.27 0.22 0.45
103 INT312826 Negative_regulation of Nppc 1 0.03 1.36 0.45
104 INT65558 Regulation of Nppc 1 0.21 0.79 0.44
105 INT166903 Negative_regulation of Gene_expression of NPPB 5 0.43 4.18 0.41
106 INT6563 Positive_regulation of Regulation of Nppa 1 0.33 0.44 0.41
107 INT72717 Gene_expression of Nppc 8 0.51 6.25 0.39
108 INT116066 Positive_regulation of Nppc 1 0.02 0.44 0.39
109 INT32533 Negative_regulation of Gene_expression of Nppa 2 0.32 1.93 0.38
110 INT146994 Regulation of NPPC 2 0.22 1.46 0.37
111 INT70531 Negative_regulation of Negative_regulation of NPR1 1 0.19 0.24 0.37
112 INT59593 Regulation of Gene_expression of NPPA 2 0.41 2.51 0.36
113 INT42659 Positive_regulation of Localization of Npr1 1 0.10 0.36 0.34
114 INT242293 Positive_regulation of Positive_regulation of NPPB 5 0.56 2.92 0.33
115 INT32566 Positive_regulation of Localization of NPR1 1 0.58 0.17 0.33
116 INT170161 Localization of NPPC 2 0.62 2.06 0.32
117 INT80117 Positive_regulation of NPPC 3 0.61 0.6 0.31
118 INT131352 Regulation of Gene_expression of Nppb 2 0.40 3.18 0.31
119 INT252267 Positive_regulation of Positive_regulation of GUCY2C 1 0.03 0.59 0.3
120 INT242985 Regulation of Gene_expression of Npr1 1 0.03 0.85 0.29
121 INT17158 Regulation of Protein_catabolism of Nppa 1 0.24 0.1 0.28
122 INT52742 Negative_regulation of Negative_regulation of Nppb 1 0.08 0.15 0.27
123 INT159473 Regulation of Localization of NPPB 2 0.61 1 0.25
124 INT76401 Localization of Nppc 2 0.54 1.09 0.24
125 INT131350 Transcription of Nppb 2 0.72 4.61 0.24
126 INT170164 Regulation of Gene_expression of NPPC 1 0.37 0.94 0.23
127 INT252264 Binding of GUCY2C 1 0.01 0.34 0.22
128 INT95576 Gene_expression of GUCY2C 4 0.42 1.78 0.21
129 INT10900 Positive_regulation of Positive_regulation of Nppb 3 0.41 3.53 0.21
130 INT16358 Positive_regulation of Negative_regulation of NPPA 2 0.41 0.83 0.21
131 INT271363 Positive_regulation of Regulation of NPPB 1 0.15 0.97 0.21
132 INT277030 Negative_regulation of Binding of NPPB 1 0.26 1.29 0.21
133 INT92135 Positive_regulation of Transcription of NPPA 1 0.03 1.17 0.2
134 INT170162 Negative_regulation of Localization of NPPC 1 0.35 0.64 0.2
135 INT236282 Transcription of Nppa 2 0.29 0.93 0.19
136 INT41153 Regulation of Binding of Npr1 1 0.01 0 0.19
137 INT92134 Transcription of NPPA 1 0.04 1.15 0.19
138 INT95575 Localization of GUCY2C 1 0.43 0 0.19
139 INT142561 Phosphorylation of NPPB 3 0.66 1.65 0.18
140 INT89848 Positive_regulation of Localization of Npr1 1 0.13 0.15 0.18
141 INT84554 Regulation of Regulation of Nppa 1 0.27 0.39 0.18
142 INT76402 Gene_expression of Nppc 2 0.30 1.8 0.17
143 INT11058 Positive_regulation of Protein_catabolism of Nppa 1 0.37 0.53 0.17
144 INT183377 Positive_regulation of Nppa 7 0.38 1.46 0.16
145 INT158445 Gene_expression of Npr2 3 0.36 1.19 0.15
146 INT153077 Positive_regulation of Gene_expression of Nppa 9 0.40 5.07 0.13
147 INT61064 Regulation of Npr2 1 0.23 0 0.1
148 INT54547 Positive_regulation of Phosphorylation of Npr1 1 0.05 0 0.1
149 INT242739 Positive_regulation of Binding of Nppa 1 0.40 1.48 0.09
150 INT257197 Phosphorylation of Npr1 1 0.03 0 0.08
151 INT290410 Negative_regulation of Transcription of Nppa 1 0.18 0.38 0.07
152 INT175695 Positive_regulation of Gene_expression of Nppc 1 0.06 1.06 0.07
153 INT7300 Negative_regulation of Binding of NPPA 1 0.38 0.83 0.07
154 INT125747 Positive_regulation of Gene_expression of Npr1 1 0.70 0.62 0.07
155 INT11120 Negative_regulation of Gene_expression of NPPA 2 0.39 1.45 0.06
156 INT31800 Positive_regulation of Binding of Npr1 1 0.08 0.06 0.06
157 INT21280 Negative_regulation of Localization of NPPA 1 0.23 0 0.06
158 INT290420 Negative_regulation of Positive_regulation of Nppa 2 0.32 0.37 0.05
159 INT242742 Negative_regulation of Gene_expression of Nppa 2 0.34 1.29 0.05
160 INT325564 Positive_regulation of Positive_regulation of Nppa 1 0.38 0.08 0.05
161 INT159886 Regulation of Gene_expression of NPPB 3 0.44 0.9 0.04
162 INT242291 Protein_catabolism of NPPB 2 0.57 1.79 0.04
163 INT254131 Negative_regulation of Localization of NPPB 1 0.37 0.72 0.04
164 INT97221 Protein_catabolism of Nppb 2 1.00 4.41 0.03
165 INT292857 Regulation of Nppa 3 0.30 1.56 0
166 INT72716 Localization of Nppc 2 0.06 0.29 0
167 INT273620 Positive_regulation of Gene_expression of GUCY2C 1 0.01 1.48 0
168 INT287855 Positive_regulation of Phosphorylation of Nppb 1 0.01 0 0
169 INT191976 Binding of Nppc 1 0.03 0.09 0
170 INT191975 Positive_regulation of Gene_expression of Nppc 1 0.03 0.09 0
171 INT212976 Negative_regulation of Gene_expression of Nppc 1 0.21 1.03 0
172 INT277040 Positive_regulation of Binding of Nppb 1 0.44 1.03 0
173 INT284146 Transcription of NPPB 1 0.06 0.27 0
174 INT273619 Negative_regulation of Gene_expression of GUCY2C 1 0.01 0.79 0
175 INT253087 Positive_regulation of Binding of NPPA 1 0.40 0.05 0
176 INT277042 Negative_regulation of Protein_catabolism of Nppb 1 0.43 1.6 0
177 INT72714 Negative_regulation of Localization of Nppc 1 0.02 0.05 0
178 INT296884 Negative_regulation of Negative_regulation of NPPB 1 0.01 1.37 0
179 INT159885 Regulation of Regulation of NPPB 1 0.44 0 0
180 INT325552 Negative_regulation of Negative_regulation of Nppa 1 0.32 0.64 0
181 INT274107 Negative_regulation of Phosphorylation of Npr1 1 0.08 0.32 0
182 INT314770 Regulation of Nppc 1 0.00 0.77 0
183 INT277039 Negative_regulation of Gene_expression of Nppb 1 0.59 4.05 0
184 INT191972 Positive_regulation of Localization of Nppc 1 0.03 0.15 0
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