GO:0007169

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Name transmembrane receptor protein tyrosine kinase signaling pathway
Categary Process
Go Slim No
Go Link GO:0007169
Unique Molecular Interactions 1396
Total Molecular Interactions 2155
Total Single Events 16601
Pain Genes Associated 86

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for transmembrane receptor protein tyrosine kinase signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for transmembrane receptor protein tyrosine kinase signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26
2 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33
3 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1
4 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
5 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23
6 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
7 INT32911 Binding of Insrr and Rbm39 2 0.00 0 3.95
8 INT108473 Binding of ADCYAP1 and PNOC 1 0.32 0.64 3.41
9 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
10 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
11 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
12 INT221746 Ngf Positive_regulation of Ntrk1 1 0.02 0.92 2.88
13 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84
14 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81
15 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
16 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67
17 INT284088 Binding of BDNF and NTRK2 5 0.41 3.4 2.37
18 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28
19 INT212301 NGF Regulation of Gene_expression of TRPV1 1 0.23 2.37 2.13
20 INT344386 Efnb1 Positive_regulation of Phosphorylation of Ephb2 1 0.15 2.85 2.13
21 INT63919 Binding of Cck and Insrr 1 0.01 0 2.08
22 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
23 INT169570 Binding of ROS1 and TRPV1 3 0.33 3.07 1.89
24 INT271408 NGF Positive_regulation of Gene_expression of CALCA 1 0.09 4.89 1.88
25 INT185097 NGF Regulation of Gene_expression of NAV1 1 0.61 0.81 1.85
26 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
27 INT99138 Coq10a Regulation of Insrr 1 0.01 0.73 1.81
28 INT136273 NGF Regulation of Gene_expression of BDNF 2 0.41 1.14 1.78
29 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
30 INT86997 Binding of HIVEP1 and NGF 2 0.03 1.75 1.73
31 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
32 INT145098 NGF Positive_regulation of BDNF 1 0.66 1.33 1.67
33 INT108385 Binding of Crygs and Ntrk1 1 0.01 0 1.67
34 INT108066 Binding of NTRK1 and Ngf 3 0.33 2.56 1.66
35 INT90929 Binding of Ap1m1 and Insrr 1 0.01 0.19 1.6
36 INT266768 NGF Positive_regulation of Localization of SFTPA1 1 0.01 1.65 1.6
37 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53
38 INT174508 Binding of CD4 and HLA-B 1 0.14 4.68 1.53
39 INT159657 Binding of INSRR and NGF 3 0.00 1.65 1.48
40 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48
41 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48
42 INT39109 Binding of INSRR and PDYN 1 0.15 0.45 1.46
43 INT266771 Binding of NGF and GOPC 1 0.05 3.23 1.43
44 INT111761 Positive_regulation of Binding of Cpe and Insrr 1 0.01 0.33 1.43
45 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43
46 INT256299 Binding of Efnb1 and Ephb1 1 0.02 1.22 1.42
47 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39
48 INT118980 NTRK1 Positive_regulation of NGF 1 0.56 1.45 1.39
49 INT138099 Binding of Grin2a and Insrr 1 0.01 0.36 1.39
50 INT83197 Binding of Ntrk1 and Gdnf 1 0.01 1.05 1.36
51 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
52 INT250934 Binding of BDNF and NGF 3 0.39 0.62 1.34
53 INT107104 Positive_regulation of Binding of Bdnf and Ntrk2 1 0.42 1.86 1.34
54 INT38624 Binding of Oprm1 and Insrr 2 0.01 0.24 1.31
55 INT181492 NGF Regulation of TRPV1 1 0.21 0.93 1.31
56 INT242605 Gdnf Positive_regulation of Trpv1 1 0.26 0.17 1.3
57 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
58 INT242623 Binding of Ntf3 and Ntrk3 5 0.22 1.31 1.29
59 INT154518 Binding of Ephb6 and Grin2b 1 0.21 0.24 1.28
60 INT112961 NGF Positive_regulation of ICAM1 1 0.40 0.96 1.28
61 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
62 INT132943 Insrr Positive_regulation of Rbm39 1 0.00 0 1.27
63 INT71109 Binding of INSRR and MC1R 1 0.01 0 1.27
64 INT132944 Positive_regulation of Insrr Positive_regulation of Rbm39 1 0.00 0 1.27
65 INT71989 Binding of Pdyn and Insrr 1 0.01 0 1.27
66 INT71990 Negative_regulation of Binding of Pdyn and Insrr 1 0.01 0 1.27
67 INT159655 Binding of BDNF and INSRR 2 0.00 1.25 1.26
68 INT287104 Binding of Ntrk2 and T 1 0.20 3.29 1.26
69 INT99695 Binding of Tspo and Insrr 1 0.02 0.52 1.25
70 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24
71 INT150595 Binding of Oprk1 and Insrr 1 0.01 0.07 1.23
72 INT256298 Binding of Creb1 and Ephb1 1 0.16 1.27 1.22
73 INT151454 Binding of Calca and Insrr 1 0.02 0.31 1.22
74 INT260833 Binding of NRP2 and Flt1 1 0.00 3.61 1.22
75 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
76 INT63384 Binding of Cnr1 and Insrr 1 0.03 0.24 1.2
77 INT108067 Negative_regulation of Binding of NTRK1 and Ngf 1 0.06 2.38 1.2
78 INT256297 Binding of Creb1 and Insrr 1 0.00 1.22 1.19
79 INT351373 Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18
80 INT98908 Binding of NTRK1 and PKLR 1 0.41 1.95 1.18
81 INT351378 Gene_expression of Ngf Positive_regulation of Ntrk1 1 0.35 0.41 1.18
82 INT32871 Binding of Insrr and Adarb1 1 0.01 0 1.18
83 INT98906 Positive_regulation of Binding of NTRK1 and PKLR 1 0.56 1.95 1.18
84 INT351377 Gene_expression of Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18
85 INT180814 Binding of Ret and Gdnf 1 0.01 1.31 1.17
86 INT299985 BDKRB2 Regulation of Gene_expression of BDKRB1 1 0.21 0.75 1.16
87 INT147446 ADCYAP1 Regulation of Localization of CP 1 0.02 1.12 1.16
88 INT242625 Gdnf Positive_regulation of Pax3 1 0.01 0.34 1.15
89 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
90 INT147448 ADCYAP1 Regulation of Localization of NFKB1 1 0.47 1.12 1.15
91 INT256041 Binding of Ngfr and Ntrk1 3 0.14 0.9 1.13
92 INT160540 Binding of NGF and PSIP1 2 0.29 1.43 1.12
93 INT346986 Binding of SHC3 and PAG1 1 0.35 1.02 1.12
94 INT242624 Binding of Ngf and Ntrk2 5 0.24 0.48 1.11
95 INT99577 Binding of KITLG and Kit 3 0.34 2.33 1.11
96 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1
97 INT298272 Runx1 Positive_regulation of Gene_expression of Ntrk3 1 0.52 0.88 1.09
98 INT298292 Runx3 Positive_regulation of Gene_expression of Ntrk3 1 0.35 1.36 1.09
99 INT142413 Oprm1 Positive_regulation of Gdnf 1 0.19 0.29 1.09
100 INT256294 Binding of Grin2b and Ephb1 1 0.28 1.11 1.08
101 INT181494 TRPV3 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
102 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
103 INT87222 Nrg1 Regulation of Oprd1 1 0.00 0 1.07
104 INT256293 Binding of Grin2b and Insrr 1 0.01 1.06 1.05
105 INT299986 BDKRB2 Regulation of Gene_expression of SPANXB1 1 0.29 0.51 1.02
106 INT344389 Ephb2 Positive_regulation of Phosphorylation of Grin2b 1 0.16 1.46 0.98
107 INT267886 Arl10 Positive_regulation of Insrr 1 0.00 0.07 0.98
108 INT41659 IL31RA Regulation of PRL 1 0.22 1.07 0.98
109 INT41658 IL31RA Regulation of GH1 1 0.09 1.07 0.98
110 INT119276 Negative_regulation of CYBB Negative_regulation of Positive_regulation of ROS1 1 0.09 1.18 0.97
111 INT127672 Binding of NGFR and NTRK1 1 0.17 2.28 0.97
112 INT66712 Binding of BDKRB2 and KNG1 1 0.06 0.22 0.97
113 INT119275 Negative_regulation of CYBB Negative_regulation of Gene_expression of ROS1 1 0.09 1.18 0.97
114 INT66711 Negative_regulation of Binding of BDKRB2 and KNG1 1 0.07 0.22 0.97
115 INT56205 Binding of Ap1m2 and Insrr 1 0.00 0.07 0.96
116 INT271409 NGF Positive_regulation of TRPV1 1 0.08 2.45 0.94
117 INT271410 NGF Positive_regulation of Gene_expression of TRPV1 1 0.07 2.45 0.94
118 INT132610 Bdnf Positive_regulation of Ntrk2 4 0.46 1.09 0.93
119 INT137921 VEGFA Positive_regulation of Ephb2 1 0.03 0 0.93
120 INT296278 Insrr Positive_regulation of Cysltr1 1 0.00 0.99 0.92
121 INT127673 NGF Regulation of Gene_expression of NTRK1 1 0.48 2.12 0.92
122 INT147507 Binding of Ret and Gtf3a 1 0.03 0.81 0.92
123 INT147505 Binding of Ret and Gdnf 1 0.27 0.81 0.92
124 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
125 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91
126 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
127 INT59503 Binding of Oprd1 and Insrr 1 0.00 0 0.89
128 INT151961 Rbm39 Positive_regulation of Insrr 1 0.17 0.26 0.89
129 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
130 INT242621 Gdnf Positive_regulation of Gene_expression of Scn11a 1 0.05 0.12 0.88
131 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
132 INT165540 NGF Positive_regulation of GRIN1 1 0.07 0.17 0.88
133 INT119274 CYBB Positive_regulation of ROS1 1 0.11 1.11 0.88
134 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87
135 INT297463 Binding of Ntrk1 and Ngf 1 0.10 0.78 0.87
136 INT298289 Runx1 Negative_regulation of Ntrk2 1 0.60 1.09 0.87
137 INT298295 Runx1 Negative_regulation of Gene_expression of Ntrk1 2 0.38 0.45 0.86
138 INT226340 Binding of CD4 and IFNA1 3 0.03 3.84 0.85
139 INT60719 Insrr Positive_regulation of Fos 1 0.03 1.23 0.84
140 INT174509 Binding of CD4 and CD28 1 0.26 1.68 0.84
141 INT299990 BDKRB2 Positive_regulation of TRPV1 1 0.43 0.74 0.84
142 INT256045 Binding of BDNF and Ntrk1 3 0.34 0.65 0.83
143 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
144 INT99578 Binding of CEL and Kit 1 0.04 1.07 0.81
145 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
146 INT245564 Runx3 Negative_regulation of Ntrk2 3 0.61 1.61 0.79
147 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
148 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
149 INT78714 Ntrk1 Positive_regulation of Ngf 2 0.50 0.63 0.78
150 INT220056 Binding of NTF3 and NTRK1 1 0.07 1.12 0.78
151 INT151453 Gtf3a Regulation of Kit 1 0.04 0.25 0.78
152 INT220063 Binding of NTF3 and NTRK2 1 0.09 1.13 0.78
153 INT187229 Binding of Tnfsf11 and Insrr 1 0.00 2.06 0.78
154 INT242626 Binding of Ngf and Ntrk3 3 0.15 0.27 0.77
155 INT70058 Binding of Pnoc and Insrr 1 0.01 0.09 0.77
156 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
157 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
158 INT111904 Binding of Gabrg1 and Insrr 1 0.02 0 0.74
159 INT33479 Positive_regulation of Oprl1 Positive_regulation of Gene_expression of Insrr 1 0.17 0.15 0.73
160 INT114860 Negative_regulation of Insrr Positive_regulation of Casp3 1 0.02 0.71 0.73
161 INT327994 Il6 Positive_regulation of Gene_expression of ROS1 1 0.05 0.55 0.73
162 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72
163 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
164 INT70011 Binding of Hrh1 and Insrr 1 0.00 0.4 0.72
165 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71
166 INT341534 INSRR Positive_regulation of F2RL1 1 0.00 1.4 0.7
167 INT144367 Gdnf Negative_regulation of Positive_regulation of Th 1 0.11 0.77 0.7
168 INT209956 Binding of CD8A and RDBP 1 0.01 0.3 0.7
169 INT351374 Mir470 Negative_regulation of Ntrk3 1 0.00 1.55 0.7
170 INT351375 Mir470 Negative_regulation of Ntrk2 1 0.01 1.54 0.7
171 INT351376 Mir470 Negative_regulation of Ntrk1 1 0.01 1.54 0.7
172 INT142244 Positive_regulation of Ntrk2 Positive_regulation of Tcrg-C1 1 0.77 0 0.67
173 INT118979 NGF Positive_regulation of Phosphorylation of NTRK1 1 0.56 0.67 0.67
174 INT144459 Binding of GPM6A and INSRR 1 0.00 0 0.67
175 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
176 INT142243 Ntrk2 Positive_regulation of Tcrg-C1 1 0.77 0 0.67
177 INT169213 Binding of EGFR and CARTPT 1 0.00 0.22 0.67
178 INT114843 NTRK1 Regulation of Gene_expression of Lgals1 1 0.06 0.84 0.66
179 INT81407 Binding of Oprl1 and Insrr 1 0.02 0.13 0.66
180 INT338390 Thim Regulation of Gene_expression of Ret 1 0.02 0.43 0.65
181 INT290549 Gopc Positive_regulation of Positive_regulation of Insr 1 0.01 0.06 0.65
182 INT221847 Binding of Calca and Ntrk1 1 0.03 0.9 0.65
183 INT114845 RET Regulation of Gene_expression of Lgals1 1 0.02 0.84 0.65
184 INT94020 Binding of EDN2 and INSRR 1 0.03 0 0.65
185 INT242635 Binding of Bdnf and Ntrk3 3 0.25 0.98 0.64
186 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
187 INT290550 Gopc Positive_regulation of Insr 1 0.01 0.06 0.64
188 INT267888 St13 Positive_regulation of Insrr 1 0.00 0.07 0.64
189 INT267891 Cpe Positive_regulation of Localization of Insrr 1 0.00 0 0.64
190 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
191 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
192 INT298262 Pou4f1 Positive_regulation of Positive_regulation of Ntrk3 1 0.36 0.79 0.63
193 INT174500 Positive_regulation of Binding of CD4 and HLA-B 1 0.21 2.33 0.63
194 INT252826 ROS1 Regulation of Gene_expression of CCL2 1 0.20 2.17 0.62
195 INT255690 Binding of VEGFA and Flt1 8 0.34 3.44 0.61
196 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
197 INT284089 Binding of NTRK2 and SERPINE1 1 0.27 0.73 0.61
198 INT327992 TRPV1 Positive_regulation of Gene_expression of ROS1 1 0.28 0.35 0.6
199 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
200 INT113163 Insrr Positive_regulation of Pscs 1 0.04 0 0.6

Single Events

The table below shows the top 100 pain related interactions that have been reported for transmembrane receptor protein tyrosine kinase signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in transmembrane receptor protein tyrosine kinase signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83
2 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9
3 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45
4 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68
5 INT4153 Binding of Insrr 109 0.40 17.99 72.15
6 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28
7 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94
8 INT12471 Regulation of Insrr 52 0.35 17.8 48.31
9 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74
10 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56
11 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43
12 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08
13 INT48890 Gene_expression of Gdnf 91 0.77 28.62 31.49
14 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11
15 INT123035 Gene_expression of Ephb1 38 0.78 28.84 27.32
16 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39
17 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
18 INT79979 Gene_expression of Ret 94 0.75 19.21 25.51
19 INT9781 Binding of INSRR 64 0.31 19.1 25.2
20 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83
21 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67
22 INT62373 Negative_regulation of NGF 34 0.59 25.87 22.38
23 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24
24 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31
25 INT99237 Gene_expression of Ntrk3 84 0.77 38.68 20.77
26 INT6848 Gene_expression of BDKRB2 40 0.75 17.19 20.04
27 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44
28 INT92733 Negative_regulation of Ephb1 19 0.51 8.56 17.72
29 INT50972 Negative_regulation of Ntrk1 39 0.51 32.22 17.29
30 INT66039 Positive_regulation of Ntrk2 53 0.69 15.87 17.23
31 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
32 INT20216 Localization of NGF 40 0.80 18.16 16.61
33 INT84924 Positive_regulation of Gene_expression of NGF 29 0.68 17.91 16.46
34 INT9783 Gene_expression of INSRR 81 0.50 32.99 15.52
35 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89
36 INT71150 Binding of NGF 22 0.46 13.67 14.81
37 INT42979 Positive_regulation of INSRR 47 0.32 12.24 14.38
38 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71
39 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
40 INT102897 Positive_regulation of Gene_expression of Gdnf 34 0.69 11.13 13.28
41 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15
42 INT69436 Negative_regulation of Gene_expression of ROS1 81 0.38 46.58 12.22
43 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
44 INT112003 Localization of ROS1 94 0.73 66.32 12.16
45 INT36287 Binding of CD4 96 0.47 58.93 11.88
46 INT135909 Positive_regulation of Ephb1 11 0.70 8.94 11.78
47 INT66718 Positive_regulation of BDKRB2 21 0.64 9.89 11.6
48 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
49 INT82950 Positive_regulation of Gdnf 36 0.51 11.72 10.5
50 INT85048 Regulation of NGF 19 0.62 11.61 10.5
51 INT16404 Regulation of CD4 54 0.61 33.05 10.29
52 INT94784 Binding of ROS1 113 0.40 71.57 10.26
53 INT10019 Binding of CD8A 57 0.36 31.49 10.08
54 INT50615 Positive_regulation of Positive_regulation of Insrr 11 0.19 5.5 10.05
55 INT33099 Negative_regulation of INSRR 32 0.40 13.82 9.85
56 INT147452 Gene_expression of ADCYAP1 14 0.77 12.54 9.28
57 INT64849 Gene_expression of Ret 24 0.75 14.36 9.1
58 INT108384 Binding of Ntrk1 28 0.39 10.73 9.09
59 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95
60 INT67116 Gene_expression of Ntrk3 20 0.59 7.64 8.94
61 INT20999 Negative_regulation of Binding of Insrr 17 0.47 3.53 8.93
62 INT132938 Phosphorylation of Insrr 21 0.03 10.55 8.88
63 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66
64 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42
65 INT12859 Localization of Insrr 16 0.32 2.68 8.07
66 INT48314 Gene_expression of NTRK2 17 0.75 7.84 7.83
67 INT11568 Gene_expression of ADORA2A 14 0.73 1.51 7.79
68 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
69 INT147715 Regulation of Gene_expression of Ephb1 6 0.62 5.26 7.49
70 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41
71 INT50973 Negative_regulation of Gene_expression of Ntrk1 22 0.56 11.12 7.38
72 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
73 INT134624 Gene_expression of Flt1 77 0.66 48.86 7.27
74 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
75 INT157430 Gene_expression of Ephb6 18 0.70 8.13 7.14
76 INT63373 Negative_regulation of Gene_expression of NGF 14 0.57 8.9 7.1
77 INT92734 Binding of Ephb1 5 0.37 3.86 7.02
78 INT69439 Regulation of ROS1 46 0.45 31.22 6.94
79 INT62260 Negative_regulation of Gene_expression of Insrr 10 0.06 1.36 6.92
80 INT150287 Positive_regulation of Ephb2 5 0.33 5.54 6.9
81 INT17049 Localization of CD4 57 0.75 35.33 6.89
82 INT74386 Gene_expression of Gfra2 8 0.42 3.64 6.88
83 INT69441 Regulation of Gene_expression of ROS1 38 0.50 26.78 6.78
84 INT63374 Regulation of Gene_expression of NGF 12 0.45 5.6 6.4
85 INT12632 Negative_regulation of Binding of INSRR 13 0.38 6.54 6.39
86 INT129020 Phosphorylation of Ntrk1 17 0.80 5.97 6.37
87 INT11154 Binding of EGFR 149 0.48 96.23 6.29
88 INT71151 Regulation of NTRK1 10 0.62 6.65 6.21
89 INT48313 Binding of NTRK1 19 0.47 14.44 6.12
90 INT12631 Positive_regulation of Binding of INSRR 11 0.45 6.13 6.04
91 INT122653 Positive_regulation of Gene_expression of CD4 48 0.68 22.5 5.96
92 INT181053 Regulation of Ephb1 6 0.45 6.17 5.77
93 INT56149 Localization of CD8A 56 0.74 30.41 5.75
94 INT115087 Negative_regulation of Gdnf 10 0.51 5.78 5.73
95 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61
96 INT242528 Gene_expression of Gfra1 15 0.09 1.17 5.61
97 INT152433 Binding of CSF1R 6 0.33 10.97 5.54
98 INT106552 Positive_regulation of Gene_expression of Ntrk2 19 0.68 9.72 5.51
99 INT71152 Negative_regulation of NTRK1 15 0.59 10.28 5.5
100 INT9325 Gene_expression of Igf1r 14 0.77 8.74 5.48
101 INT83095 Regulation of Gene_expression of BDKRB2 2 0.59 4.06 5.39
102 INT16405 Regulation of CD8A 38 0.45 19.04 5.31
103 INT107103 Negative_regulation of Ntrk2 21 0.59 10.38 5.28
104 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23
105 INT83056 Transcription of Insrr 11 0.11 2.43 5.11
106 INT106555 Binding of Ntrk2 15 0.48 6.31 5.05
107 INT48277 Regulation of BDKRB2 9 0.59 2.69 5.05
108 INT152742 Positive_regulation of Localization of NGF 7 0.50 4.44 5.02
109 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
110 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93
111 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
112 INT12474 Regulation of INSRR 18 0.29 6.29 4.81
113 INT78626 Regulation of Gdnf 7 0.45 3.3 4.64
114 INT103155 Gene_expression of KDR 78 0.66 50.53 4.38
115 INT81750 Regulation of Ntrk1 13 0.52 6.03 4.37
116 INT103914 Phosphorylation of Egfr 35 0.82 16.98 4.31
117 INT122882 Regulation of Ntrk2 13 0.62 9.7 4.3
118 INT55456 Regulation of Gene_expression of Insrr 9 0.03 3 4.24
119 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13
120 INT144428 Positive_regulation of Gene_expression of Erbb2 41 0.69 41.4 4.13
121 INT88278 Binding of Kit 33 0.37 24.45 4.13
122 INT15771 Gene_expression of Nrg1 34 0.67 3.16 4.11
123 INT100372 Gene_expression of Flt1 47 0.71 24.33 4.09
124 INT25841 Regulation of Binding of Insrr 6 0.50 0.4 4.03
125 INT200047 Negative_regulation of Gene_expression of Ntrk2 8 0.56 10.78 3.95
126 INT33332 Positive_regulation of Binding of Insrr 6 0.38 0.77 3.94
127 INT152254 Gene_expression of CSF1R 16 0.75 12.93 3.81
128 INT146946 Gene_expression of Lyn 16 0.76 8.9 3.75
129 INT84925 Transcription of NGF 11 0.65 4.13 3.65
130 INT133590 Gene_expression of Nrtn 17 0.55 6.1 3.64
131 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61
132 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6
133 INT242569 Positive_regulation of Ret 17 0.55 3.61 3.54
134 INT78625 Regulation of Gene_expression of Gdnf 7 0.37 2.5 3.47
135 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45
136 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
137 INT53347 Localization of BDKRB2 5 0.75 4.96 3.39
138 INT69438 Negative_regulation of Positive_regulation of ROS1 20 0.48 10.6 3.33
139 INT106341 Phosphorylation of Irs1 18 0.72 14.7 3.3
140 INT140555 Positive_regulation of Localization of ROS1 29 0.55 23.82 3.14
141 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
142 INT120562 Negative_regulation of Egfr 108 0.59 79.38 3.11
143 INT66720 Negative_regulation of BDKRB2 5 0.57 1.92 3.11
144 INT117348 Regulation of EGFR 75 0.61 47.73 3.09
145 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09
146 INT51178 Transcription of INSRR 9 0.17 2.09 3.09
147 INT33241 Localization of INSRR 10 0.10 1.24 3.08
148 INT91890 Positive_regulation of Kit 36 0.50 25.44 3.06
149 INT298246 Positive_regulation of Ntrk3 7 0.48 3.81 3.01
150 INT53348 Binding of BDKRB2 7 0.37 2.85 3
151 INT93109 Phosphorylation of NTRK1 5 0.80 3.22 2.99
152 INT137907 Phosphorylation of Ephb2 2 0.61 2.78 2.96
153 INT177993 Localization of CSF1R 4 0.73 7.49 2.94
154 INT156189 Positive_regulation of Gene_expression of Ntrk1 11 0.49 2.81 2.89
155 INT106340 Positive_regulation of Phosphorylation of Irs1 8 0.53 7.03 2.85
156 INT209744 Transcription of Gdnf 5 0.67 1.36 2.84
157 INT8095 Gene_expression of ERBB3 47 0.77 24.85 2.82
158 INT142237 Phosphorylation of Ntrk2 8 0.82 2.24 2.82
159 INT256286 Negative_regulation of Gene_expression of Ephb1 1 0.43 3.36 2.78
160 INT157429 Negative_regulation of Ephb6 3 0.35 2.17 2.77
161 INT95037 Negative_regulation of Regulation of Insrr 1 0.02 0 2.77
162 INT150286 Gene_expression of Ephb2 3 0.39 2.57 2.74
163 INT178002 Positive_regulation of CSF1R 2 0.37 6.52 2.74
164 INT280459 Regulation of Gene_expression of Ntrk2 13 0.62 8.48 2.71
165 INT119518 Positive_regulation of Gene_expression of NTRK1 5 0.67 3.47 2.66
166 INT163405 Positive_regulation of Binding of ROS1 15 0.27 9.39 2.58
167 INT132685 Negative_regulation of NTRK2 4 0.42 2.89 2.58
168 INT77213 Transcription of ADORA2A 1 0.69 0 2.55
169 INT38631 Positive_regulation of Ret 8 0.39 3.23 2.52
170 INT59119 Positive_regulation of ADCYAP1 9 0.69 4.68 2.48
171 INT95799 Binding of NTRK2 8 0.35 2.95 2.47
172 INT137908 Phosphorylation of Pdgfrb 14 0.81 8.44 2.45
173 INT63333 Gene_expression of RET 24 0.76 30.09 2.41
174 INT144366 Negative_regulation of Positive_regulation of Gdnf 4 0.41 1.43 2.41
175 INT97485 Localization of ADCYAP1 4 0.78 0.24 2.35
176 INT242548 Regulation of Gene_expression of Ret 7 0.49 1.2 2.33
177 INT83058 Regulation of Positive_regulation of Insrr 2 0.11 0.66 2.31
178 INT172808 Positive_regulation of Positive_regulation of ROS1 35 0.40 31.39 2.27
179 INT92388 Gene_expression of ALK 16 0.78 22.46 2.26
180 INT146945 Positive_regulation of Lyn 6 0.49 2.81 2.25
181 INT151449 Negative_regulation of Gene_expression of Kit 18 0.45 12.05 2.23
182 INT50392 Regulation of Ret 6 0.54 3.51 2.22
183 INT107102 Negative_regulation of Positive_regulation of Ntrk2 6 0.54 1.61 2.21
184 INT242551 Negative_regulation of Gene_expression of Ret 5 0.41 1.01 2.21
185 INT147417 Positive_regulation of Gene_expression of Igf1r 3 0.46 1.69 2.2
186 INT176088 Gene_expression of Tek 39 0.65 14.25 2.19
187 INT103917 Positive_regulation of Phosphorylation of Egfr 12 0.68 7.23 2.18
188 INT85085 Positive_regulation of KIT 36 0.53 30.08 2.17
189 INT183159 Gene_expression of Epha1 3 0.25 3.15 2.17
190 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15
191 INT147453 Positive_regulation of Gene_expression of ADCYAP1 3 0.69 3.49 2.1
192 INT63375 Positive_regulation of Positive_regulation of NGF 2 0.48 1.17 2.08
193 INT122881 Negative_regulation of Ntrk3 10 0.51 5.52 2.04
194 INT147451 Regulation of Gene_expression of ADCYAP1 3 0.61 1.88 2.04
195 INT168983 Negative_regulation of Nrg1 11 0.43 3.4 2.03
196 INT102896 Binding of Ret 8 0.35 1.55 2.03
197 INT100371 Positive_regulation of Flt1 11 0.63 6.42 2.02
198 INT127944 Negative_regulation of Localization of ROS1 8 0.36 3.14 2.02
199 INT237322 Gene_expression of Irs1 52 0.77 21.07 2
200 INT58691 Positive_regulation of Gene_expression of CD8A 26 0.50 15.19 1.97
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