GO:0007171

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Name activation of transmembrane receptor protein tyrosine kinase activity
Categary Process
Go Slim No
Go Link GO:0007171
Unique Molecular Interactions 63
Total Molecular Interactions 79
Total Single Events 536
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of transmembrane receptor protein tyrosine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for activation of transmembrane receptor protein tyrosine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
2 INT204558 Tens1 Negative_regulation of Pdgfc 1 0.01 0.25 1.2
3 INT87222 Nrg1 Regulation of Oprd1 1 0.00 0 1.07
4 INT66188 Binding of ADRB2 and CDSN 1 0.01 0 0.51
5 INT254348 Binding of ANGPT1 and TEK 1 0.04 1.72 0.48
6 INT151890 Binding of PRLR and Adarb1 1 0.00 0 0.45
7 INT92744 Binding of ADRB2 and NF2 1 0.00 0.1 0.41
8 INT85037 Binding of Cct2 and Chrna3 1 0.00 0.15 0.38
9 INT224700 TNF Positive_regulation of Angpt1 1 0.00 0.63 0.34
10 INT181899 TNF Regulation of ANGPT1 1 0.03 1.22 0.33
11 INT263974 Binding of ADRB2 and NR4A3 1 0.01 0.5 0.32
12 INT263978 Binding of ADRB2 and TNFAIP3 1 0.01 0.5 0.32
13 INT263979 Binding of ADRB2 and ATF3 1 0.01 0.5 0.32
14 INT62616 Regulation of Binding of PRLR and ST14 1 0.00 0 0.31
15 INT62615 Binding of PRLR and ST14 1 0.00 0 0.31
16 INT141634 Binding of Alb and Nrg1 1 0.00 0.3 0.26
17 INT134522 Nrg1 Regulation of Gene_expression of Mpz 1 0.60 0.29 0.25
18 INT134523 Nrg1 Positive_regulation of Gene_expression of Mpz 1 0.49 0.32 0.23
19 INT25907 Binding of PRLR and Cish 1 0.00 0 0.23
20 INT151884 Binding of PRLR and YY1 1 0.01 0 0.23
21 INT303029 Binding of TEK and Angpt1 1 0.26 1.82 0.22
22 INT29099 Binding of ADRB2 and PPAP2A 1 0.03 0.77 0.22
23 INT9716 Binding of Egf and Pdgfc 1 0.20 0 0.22
24 INT326575 Nrg1 Positive_regulation of Gene_expression of JUN 1 0.38 0.86 0.2
25 INT68510 Binding of ATM and PRLR 1 0.01 0 0.19
26 INT261628 Binding of CHRNA3 and MAOA 1 0.22 1.61 0.17
27 INT349659 PYCARD Positive_regulation of ADRB2 1 0.06 0.19 0.17
28 INT231274 Nrg1 Regulation of Gene_expression of Akt1 1 0.19 0 0.14
29 INT211996 Erbb3 Positive_regulation of Nrg1 2 0.03 0.67 0.11
30 INT192249 Angpt1 Positive_regulation of Localization of NOS3 1 0.01 0.46 0.09
31 INT231273 Binding of Egfr and Nrg1 1 0.12 0 0.09
32 INT341008 Nrg1 Regulation of Binding of Erbb4 1 0.04 0 0.09
33 INT192248 Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
34 INT192250 Positive_regulation of Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
35 INT54096 NRG1 Regulation of Protein_catabolism of Fgg 1 0.01 0 0.09
36 INT261625 Binding of CHRNA3 and CPD 1 0.07 0.35 0.08
37 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
38 INT178501 Angpt1 Positive_regulation of Tek 1 0.06 0.78 0.04
39 INT341009 Nrg1 Positive_regulation of Gene_expression of Fabp7 1 0.10 0.49 0.04
40 INT231276 Erbb4 Positive_regulation of Nrg1 2 0.35 0.06 0.03
41 INT316057 Binding of Erbb4 and Nrg1 2 0.03 0.38 0.03
42 INT298703 Angpt1 Regulation of Tek 1 0.12 0.27 0.03
43 INT316061 Positive_regulation of Binding of Erbb4 and Nrg1 1 0.03 0.38 0.03
44 INT231275 Erbb4 Positive_regulation of Gene_expression of Nrg1 1 0.35 0 0.03
45 INT334869 Nrg1 Positive_regulation of Phosphorylation of C3 1 0.08 0 0.03
46 INT291199 Binding of VEGFA and Angpt1 1 0.08 0.69 0
47 INT341005 Binding of Vim and Nrg1 1 0.05 0.14 0
48 INT292088 Binding of AMELX and ANGPT1 1 0.00 0.9 0
49 INT294066 ANGPT1 Positive_regulation of VEGFA 1 0.01 0.1 0
50 INT109817 Ace2 Positive_regulation of Angpt1 1 0.05 0.31 0
51 INT341013 Binding of Erbb3 and Nrg1 1 0.04 0.14 0
52 INT268887 Binding of ANGPT1 and Tek 1 0.10 0 0
53 INT176096 Regulation of Binding of Angpt1 and Tek 1 0.07 0.54 0
54 INT341023 PIK3CB Positive_regulation of Nrg1 1 0.03 0.06 0
55 INT176097 Binding of Angpt1 and Tek 1 0.06 0.48 0
56 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
57 INT341010 Nrg1 Positive_regulation of Regulation of Vim 1 0.07 0 0
58 INT341014 Positive_regulation of Binding of Erbb3 and Nrg1 1 0.06 0.14 0
59 INT317778 Binding of ADRB2 and GOPC 1 0.10 0.69 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of transmembrane receptor protein tyrosine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in activation of transmembrane receptor protein tyrosine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT12367 Binding of PRLR 17 0.03 2.05 9.69
2 INT29411 Positive_regulation of ADRB2 13 0.65 5.42 8.78
3 INT7883 Binding of ADRB2 18 0.47 5.49 7.37
4 INT1243 Regulation of ADRB2 16 0.54 1.84 5.66
5 INT13313 Regulation of PRLR 7 0.07 1.65 4.77
6 INT15771 Gene_expression of Nrg1 34 0.67 3.16 4.11
7 INT484 Negative_regulation of ADRB2 13 0.59 2.85 3.94
8 INT18825 Gene_expression of PRLR 8 0.40 2 3.47
9 INT20082 Positive_regulation of PRLR 6 0.29 4.27 3.03
10 INT41474 Gene_expression of ADRB2 10 0.75 1.56 2.94
11 INT25646 Negative_regulation of PRLR 5 0.08 0.08 2.62
12 INT34266 Negative_regulation of Binding of PRLR 3 0.01 0 2.35
13 INT70725 Negative_regulation of Binding of ADRB2 3 0.57 0.4 2.14
14 INT153718 Gene_expression of ANGPT1 15 0.45 10.82 2.13
15 INT168983 Negative_regulation of Nrg1 11 0.43 3.4 2.03
16 INT52618 Positive_regulation of Pdgfc 3 0.33 0.82 1.9
17 INT40832 Localization of ADRB2 5 0.73 2.21 1.81
18 INT105784 Binding of Nrg1 7 0.37 1.29 1.52
19 INT123926 Gene_expression of Angpt1 28 0.54 21.74 1.47
20 INT138699 Gene_expression of Pdgfc 5 0.30 3.32 1.46
21 INT158056 Localization of Nrg1 13 0.79 3.11 1.28
22 INT178494 Gene_expression of Angpt1 10 0.37 9.77 1.28
23 INT109078 Positive_regulation of ANGPT1 7 0.22 3.08 1.21
24 INT61094 Gene_expression of Pdgfc 3 0.09 1.97 1.21
25 INT30851 Gene_expression of NRG1 8 0.67 4.64 1.12
26 INT20080 Localization of PRLR 2 0.03 0.42 1.12
27 INT41475 Positive_regulation of Localization of ADRB2 2 0.49 0.18 1.12
28 INT101994 Positive_regulation of Nrg1 10 0.50 1.24 1.05
29 INT52186 Positive_regulation of Positive_regulation of ADRB2 1 0.14 0 1.02
30 INT19084 Negative_regulation of NRG1 5 0.42 4.9 0.96
31 INT46485 Positive_regulation of Pdgfc 3 0.18 2.74 0.92
32 INT70726 Positive_regulation of Negative_regulation of ADRB2 1 0.49 0.2 0.86
33 INT109080 Negative_regulation of ANGPT1 8 0.14 3.17 0.82
34 INT139846 Protein_catabolism of Nrg1 5 0.60 1.78 0.74
35 INT123927 Positive_regulation of Gene_expression of Angpt1 12 0.48 10.18 0.71
36 INT126736 Positive_regulation of Gene_expression of Nrg1 3 0.50 0.42 0.71
37 INT67452 Positive_regulation of Regulation of ADRB2 1 0.41 0.26 0.68
38 INT85033 Positive_regulation of Chrna3 2 0.06 0.35 0.67
39 INT133004 Gene_expression of Chrna3 2 0.58 0.63 0.66
40 INT290081 Regulation of NRG1 7 0.26 5.24 0.59
41 INT15770 Negative_regulation of Gene_expression of Nrg1 3 0.43 1.27 0.5
42 INT95375 Regulation of Transcription of PRLR 1 0.00 0 0.49
43 INT95377 Regulation of Gene_expression of PRLR 1 0.00 0 0.49
44 INT95376 Transcription of PRLR 1 0.00 0 0.49
45 INT19083 Positive_regulation of NRG1 3 0.20 0.65 0.48
46 INT107323 Regulation of Gene_expression of Pdgfc 1 0.01 0.96 0.44
47 INT96909 Regulation of Angpt1 2 0.17 0.37 0.43
48 INT178497 Positive_regulation of Gene_expression of Angpt1 4 0.19 3.65 0.39
49 INT128845 Phosphorylation of ADRB2 1 0.01 0 0.39
50 INT40833 Negative_regulation of Localization of ADRB2 2 0.40 0.58 0.38
51 INT290096 Regulation of Gene_expression of NRG1 2 0.06 2.21 0.35
52 INT334851 Positive_regulation of Localization of Nrg1 1 0.30 0.68 0.34
53 INT61095 Positive_regulation of Gene_expression of Pdgfc 1 0.07 0.47 0.34
54 INT131231 Binding of Pdgfc 1 0.01 0.77 0.29
55 INT317793 Regulation of Gene_expression of ADRB2 1 0.45 0.26 0.27
56 INT20081 Positive_regulation of Localization of PRLR 1 0.03 0.07 0.27
57 INT203557 Transcription of NRG1 2 0.31 0.7 0.24
58 INT96908 Protein_catabolism of Angpt1 1 0.41 0.26 0.24
59 INT220396 Negative_regulation of Angpt1 4 0.26 1.64 0.23
60 INT181791 Positive_regulation of Gene_expression of ANGPT1 1 0.29 1.27 0.2
61 INT62617 Positive_regulation of Positive_regulation of PRLR 1 0.01 0 0.19
62 INT95662 Binding of Chrna3 1 0.00 0.17 0.17
63 INT156590 Negative_regulation of Negative_regulation of ANGPT1 1 0.10 0.33 0.16
64 INT54093 Protein_catabolism of NRG1 1 0.26 0 0.16
65 INT231261 Regulation of Nrg1 3 0.31 1.32 0.15
66 INT220571 Positive_regulation of Protein_catabolism of Nrg1 1 0.30 0.08 0.15
67 INT290923 Positive_regulation of Angpt1 3 0.48 3.62 0.14
68 INT261639 Positive_regulation of CHRNA3 1 0.38 0.68 0.14
69 INT203559 Positive_regulation of Transcription of NRG1 1 0.22 0 0.11
70 INT354414 Localization of ANGPT1 1 0.10 0 0.1
71 INT54092 Regulation of Protein_catabolism of NRG1 1 0.13 0 0.09
72 INT261646 Localization of CHRNA3 1 0.65 0.91 0.09
73 INT329735 Negative_regulation of Protein_catabolism of Nrg1 1 0.36 0.49 0.08
74 INT291188 Regulation of Gene_expression of Angpt1 1 0.31 1.78 0.08
75 INT291183 Negative_regulation of Angpt1 1 0.30 0.89 0.08
76 INT54094 Positive_regulation of Protein_catabolism of NRG1 1 0.14 0 0.07
77 INT291195 Negative_regulation of Gene_expression of Angpt1 1 0.41 2.29 0.07
78 INT209147 Regulation of Transcription of ADRB2 1 0.27 0 0.07
79 INT334840 Positive_regulation of Phosphorylation of Nrg1 1 0.30 0 0.06
80 INT209148 Transcription of ADRB2 1 0.53 0 0.06
81 INT290102 Localization of NRG1 1 0.15 0.76 0.06
82 INT290930 Localization of Angpt1 1 0.21 0 0.06
83 INT290916 Regulation of Angpt1 2 0.31 1.01 0.04
84 INT258065 Protein_catabolism of ANGPT1 1 0.01 0.47 0.04
85 INT220593 Negative_regulation of Localization of Nrg1 1 0.26 0.07 0.04
86 INT291193 Binding of Angpt1 1 0.26 1.87 0.04
87 INT334841 Negative_regulation of Phosphorylation of Nrg1 1 0.26 0 0.03
88 INT340964 Positive_regulation of Negative_regulation of Nrg1 1 0.28 0.12 0.03
89 INT334845 Phosphorylation of Nrg1 1 0.49 0 0.03
90 INT294078 Regulation of ANGPT1 3 0.04 1.25 0
91 INT268882 Binding of ANGPT1 3 0.07 0.89 0
92 INT294081 Negative_regulation of Gene_expression of ANGPT1 2 0.04 0.19 0
93 INT199568 Negative_regulation of Pdgfc 1 0.05 0.59 0
94 INT331174 Localization of Pdgfc 1 0.03 0.54 0
95 INT340965 Negative_regulation of Binding of Nrg1 1 0.24 0 0
96 INT220588 Transcription of Nrg1 1 0.41 0.64 0
97 INT171658 Binding of NRG1 1 0.05 0.17 0
98 INT349673 Positive_regulation of Gene_expression of ADRB2 1 0.14 0 0
99 INT340954 Positive_regulation of Positive_regulation of Nrg1 1 0.28 0 0
100 INT234187 Positive_regulation of Gene_expression of NRG1 1 0.02 0.32 0
101 INT340974 Negative_regulation of Negative_regulation of Nrg1 1 0.24 0 0
102 INT231271 Regulation of Localization of Nrg1 1 0.45 0 0
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