GO:0007172

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Name signal complex assembly
Categary Process
Go Slim No
Go Link GO:0007172
Unique Molecular Interactions 102
Total Molecular Interactions 128
Total Single Events 910
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for signal complex assembly. They are ordered first by their pain relevance and then by number of times they were reported for signal complex assembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
2 INT116930 OPRK1 Positive_regulation of Binding of PTK2 1 0.28 0.35 0.93
3 INT116109 VEGFA Positive_regulation of PTK2 1 0.13 0.3 0.83
4 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
5 INT133675 NPY6R Negative_regulation of SRC 1 0.17 0.75 0.74
6 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
7 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
8 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
9 INT116935 Positive_regulation of OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.47
10 INT116939 OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.46
11 INT116934 OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
12 INT116928 PTK2 Positive_regulation of JUN 1 0.20 0.15 0.46
13 INT116933 SRC Positive_regulation of JUN 1 0.33 0.15 0.46
14 INT116937 Positive_regulation of OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
15 INT117776 Binding of Ptk2 and Regulation of Phosphorylation of Ddr1 1 0.10 0.17 0.46
16 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
17 INT353392 Binding of DRD4 and NCK1 1 0.37 0.62 0.37
18 INT353390 Binding of DRD4 and SRC 1 0.25 0.62 0.37
19 INT295360 Ntn1 Positive_regulation of Ptk2 1 0.09 0.51 0.29
20 INT118853 Negative_regulation of SRC Negative_regulation of Positive_regulation of STAT3 1 0.41 0.08 0.28
21 INT118855 Binding of SRC and GNA14 1 0.01 0.13 0.27
22 INT100680 IL4 Positive_regulation of SRC 1 0.42 0.66 0.26
23 INT118857 PLCB1 Regulation of Phosphorylation of SRC 1 0.01 0.15 0.24
24 INT118858 PRKCA Regulation of Phosphorylation of SRC 1 0.10 0.15 0.24
25 INT118850 GNA14 Positive_regulation of Phosphorylation of SRC 1 0.02 0.15 0.23
26 INT283858 Binding of PTK2 and APOA5 1 0.00 0.67 0.21
27 INT178074 EDN1 Positive_regulation of Phosphorylation of PXN 1 0.05 0.82 0.2
28 INT178086 Binding of EDNRA and PTK2 1 0.07 0.82 0.2
29 INT304964 Binding of AMT and PTK2B 1 0.23 0.78 0.18
30 INT178092 EDN3 Positive_regulation of PTK2 1 0.01 1.02 0.17
31 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
32 INT147727 Phosphorylation of PTK2 Regulation of Positive_regulation of RAC1 1 0.34 0.32 0.14
33 INT147726 Phosphorylation of PTK2 Regulation of Positive_regulation of PIK3CA 1 0.09 0.32 0.14
34 INT177980 CSF1R Regulation of PXN 1 0.07 0.48 0.11
35 INT292087 SRC Regulation of IL8 1 0.02 1.43 0.11
36 INT327405 Lox Positive_regulation of Ptk2 1 0.42 1.3 0.1
37 INT206056 PTK2B Negative_regulation of Positive_regulation of IRF6 1 0.00 0.66 0.1
38 INT178089 Binding of EDNRA and Positive_regulation of PTK2 1 0.09 0.74 0.09
39 INT355582 VEGFA Regulation of Positive_regulation of PTK2 1 0.05 1.46 0.08
40 INT329265 Binding of Ptk2 and Wnt2 1 0.05 1.04 0.07
41 INT333260 Gene_expression of Cxcl12 Negative_regulation of Gene_expression of Ptk2 1 0.21 1 0.07
42 INT333257 Gene_expression of Cxcl12 Negative_regulation of Ptk2 1 0.21 1 0.07
43 INT299291 Negative_regulation of PTPN3 Positive_regulation of Phosphorylation of SRC 1 0.07 0.12 0.07
44 INT235006 IgG Positive_regulation of SRC 1 0.01 0.82 0.05
45 INT235010 Positive_regulation of Positive_regulation of SRC 1 0.01 0.84 0.05
46 INT346280 Binding of COL5A2 and PTK2 1 0.01 0.1 0.05
47 INT269249 Ptk2 Positive_regulation of Phosphorylation of Src 1 0.13 0.93 0.04
48 INT269250 Ptk2 Positive_regulation of Src 1 0.13 0.86 0.04
49 INT290312 Binding of CASP1 and NCK1 1 0.00 0.29 0.04
50 INT238113 SRC Regulation of Phosphorylation of STAT3 1 0.46 0 0.04
51 INT89385 INS Positive_regulation of Phosphorylation of PTK2B 1 0.15 0.59 0.04
52 INT271526 Binding of ESB3 and Ptk2 1 0.01 0.97 0.03
53 INT302126 PTGER2 Positive_regulation of SRC 1 0.11 1.08 0.03
54 INT213905 ESR1 Positive_regulation of SRC 1 0.14 0.31 0.03
55 INT351680 Fut1 Regulation of Ptk2 1 0.01 1.68 0
56 INT338198 SRC Positive_regulation of STAT3 1 0.11 0.34 0
57 INT292464 Binding of PTK2 and MMRN1 1 0.03 0.26 0
58 INT292505 PTK2 Regulation of Birc5 1 0.29 0.76 0
59 INT292444 BAD Positive_regulation of Phosphorylation of PTK2 1 0.13 0.9 0
60 INT299303 SRC Regulation of Phosphorylation of VEGFA 1 0.12 0.05 0
61 INT292463 LAMB2 Positive_regulation of Phosphorylation of PTK2 1 0.01 0.7 0
62 INT285579 Binding of S100A8 and SRC 1 0.05 0.2 0
63 INT299305 VEGFA Positive_regulation of Positive_regulation of SRC 1 0.22 0 0
64 INT299300 SRC Positive_regulation of Phosphorylation of AKT1 1 0.24 0 0
65 INT279289 TXK Regulation of SRC 1 0.04 0.68 0
66 INT299296 SRC Regulation of RPTOR 1 0.32 0 0
67 INT292497 Mlph Positive_regulation of Phosphorylation of PTK2 1 0.05 7.24 0
68 INT269248 Lox Negative_regulation of Ptk2 1 0.24 1.02 0
69 INT292498 Mlph Regulation of Phosphorylation of PTK2 1 0.02 0.33 0
70 INT114712 SRC Positive_regulation of Gene_expression of IGF1R 1 0.63 0.51 0
71 INT338189 SRC Positive_regulation of HGFAC 1 0.00 0.4 0
72 INT292452 Gene_expression of PTK2 Negative_regulation of Positive_regulation of AKT1 1 0.14 0.6 0
73 INT284914 Binding of HDAC1 and NCK1 1 0.00 0.13 0
74 INT299285 SRC Regulation of Gene_expression of QPCT 1 0.03 0 0
75 INT302174 Positive_regulation of SRC Positive_regulation of Phosphorylation of STAT3 1 0.11 1.01 0
76 INT302142 PTGER3 Positive_regulation of SRC 1 0.09 1.07 0
77 INT292453 PTK2 Regulation of Gene_expression of GEM 1 0.16 0.42 0
78 INT283863 Binding of MAPK1 and PTK2 1 0.12 0.97 0
79 INT295409 Ptk2 Positive_regulation of Phosphorylation of Oprk1 1 0.01 0 0
80 INT299308 SRC Regulation of PI3 1 0.20 0 0
81 INT299298 SRC Negative_regulation of PI3 1 0.19 0 0
82 INT338195 Binding of SRC and FIBP 1 0.00 0.31 0
83 INT309906 Binding of EGF and SRC 1 0.11 0.64 0
84 INT292495 Mlph Regulation of Gene_expression of PTK2 1 0.03 0.21 0
85 INT292461 PTK2 Regulation of BCL2 1 0.02 0.76 0
86 INT114713 Binding of IGF1R and SRC 1 0.33 0.6 0
87 INT340928 Negative_regulation of SRC Negative_regulation of Positive_regulation of AKT1 1 0.00 0 0
88 INT299294 SRC Regulation of VEGFA 1 0.20 0 0
89 INT292451 PTK2 Regulation of BAX 1 0.02 0.76 0
90 INT238120 SRC Positive_regulation of Positive_regulation of STAT3 1 0.71 0 0
91 INT238114 Binding of CSK and SRC 1 0.07 0 0
92 INT351158 CAV1 Regulation of SRC 1 0.01 0.68 0
93 INT292448 Positive_regulation of PTK2 Positive_regulation of Phosphorylation of AKT1 1 0.15 0.28 0
94 INT295402 Ptk2 Positive_regulation of Localization of Oprk1 1 0.01 0 0
95 INT292457 PTK2 Regulation of BAD 1 0.03 0.76 0
96 INT351676 Fut1 Negative_regulation of Ptk2 1 0.01 4.39 0
97 INT338196 Binding of SRC and CDCP1 1 0.00 0.31 0
98 INT292506 Mlph Regulation of PTK2 1 0.01 0.21 0
99 INT198019 NPY6R Negative_regulation of Gene_expression of SRC 1 0.06 1.75 0
100 INT351677 Fut1 Negative_regulation of Gene_expression of Ptk2 1 0.01 3.64 0
101 INT292460 GEM Positive_regulation of Phosphorylation of PTK2 1 0.20 0.52 0
102 INT114711 SRC Positive_regulation of Gene_expression of INSRR 1 0.01 0.51 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for signal complex assembly. They are ordered first by their pain relevance and then by number of times they were reported in signal complex assembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27
2 INT83597 Phosphorylation of Ptk2 20 0.82 3.24 5.7
3 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47
4 INT87345 Phosphorylation of PTK2 110 0.82 59.39 4.28
5 INT117773 Positive_regulation of Phosphorylation of Ptk2 9 0.69 0.89 3.71
6 INT100688 Gene_expression of SRC 28 0.75 15.51 3.08
7 INT98464 Positive_regulation of Positive_regulation of SRC 10 0.67 5.71 1.86
8 INT83596 Gene_expression of Ptk2 6 0.76 2.22 1.84
9 INT82609 Phosphorylation of SRC 17 0.80 6.45 1.7
10 INT116110 Positive_regulation of PTK2 20 0.66 10.53 1.64
11 INT206471 Positive_regulation of Ptk2 34 0.51 25.75 1.61
12 INT111946 Positive_regulation of Phosphorylation of PTK2 8 0.66 11.5 1.53
13 INT131115 Regulation of Phosphorylation of Ptk2 2 0.61 0.3 1.34
14 INT114715 Binding of SRC 8 0.36 4.26 1.32
15 INT78692 Regulation of PTK2B 2 0.47 0.29 1.28
16 INT87343 Negative_regulation of Phosphorylation of PTK2 34 0.59 18.38 1.19
17 INT87346 Binding of PTK2 6 0.37 4.03 1.18
18 INT219950 Negative_regulation of Gene_expression of SRC 2 0.29 1.32 1.15
19 INT87342 Regulation of Phosphorylation of PTK2 3 0.59 5.7 1.05
20 INT87344 Gene_expression of PTK2 90 0.78 59.03 0.87
21 INT131113 Negative_regulation of Ptk2 3 0.58 0.17 0.85
22 INT118004 Positive_regulation of Gene_expression of SRC 13 0.49 11.05 0.8
23 INT134207 Gene_expression of Ptk2 56 0.73 31.97 0.78
24 INT87341 Regulation of Gene_expression of PTK2 2 0.62 8.34 0.77
25 INT134208 Negative_regulation of Ptk2 19 0.58 23.59 0.52
26 INT82608 Positive_regulation of Phosphorylation of SRC 3 0.49 1.28 0.48
27 INT117772 Binding of Ptk2 1 0.37 0.17 0.46
28 INT109920 Positive_regulation of PTK2B 5 0.43 2.21 0.43
29 INT271521 Phosphorylation of Ptk2 10 0.59 11.45 0.39
30 INT109922 Negative_regulation of PTK2B 3 0.26 1.63 0.39
31 INT109919 Positive_regulation of Positive_regulation of PTK2B 1 0.31 0.09 0.35
32 INT134738 Gene_expression of NCK1 2 0.01 0.14 0.34
33 INT138051 Negative_regulation of Positive_regulation of SRC 3 0.57 0.84 0.33
34 INT83594 Negative_regulation of Phosphorylation of Ptk2 5 0.42 1.62 0.29
35 INT271522 Negative_regulation of Phosphorylation of Ptk2 3 0.19 2.09 0.26
36 INT178106 Phosphorylation of PXN 2 0.12 1.14 0.25
37 INT119080 Negative_regulation of PTK2 15 0.56 8.88 0.23
38 INT87338 Regulation of PTK2 10 0.62 4.75 0.21
39 INT164162 Negative_regulation of Phosphorylation of SRC 3 0.29 2.12 0.21
40 INT308522 Positive_regulation of Positive_regulation of Ptk2 2 0.22 2.37 0.21
41 INT235725 Regulation of SRC 7 0.44 4.71 0.19
42 INT89400 Phosphorylation of PTK2B 4 0.38 1.16 0.19
43 INT292483 Negative_regulation of Positive_regulation of PTK2 2 0.41 3.51 0.18
44 INT283561 Regulation of Gene_expression of Ptk2 5 0.42 1.1 0.17
45 INT147730 Regulation of Positive_regulation of PTK2 1 0.35 0.33 0.15
46 INT83595 Negative_regulation of Gene_expression of Ptk2 1 0.23 1.62 0.14
47 INT131114 Positive_regulation of Gene_expression of Ptk2 1 0.49 0.27 0.14
48 INT327399 Negative_regulation of Positive_regulation of Ptk2 7 0.43 4.75 0.13
49 INT269240 Regulation of Ptk2 6 0.42 2.84 0.13
50 INT283567 Regulation of Regulation of Ptk2 1 0.42 0.3 0.13
51 INT89409 Negative_regulation of Phosphorylation of PTK2B 2 0.13 0.89 0.12
52 INT177991 Regulation of PXN 2 0.04 0.56 0.1
53 INT135555 Localization of PTK2B 1 0.57 0.32 0.1
54 INT283560 Negative_regulation of Gene_expression of Ptk2 6 0.40 4.84 0.09
55 INT299357 Localization of SRC 1 0.51 0 0.09
56 INT271523 Positive_regulation of Gene_expression of Ptk2 6 0.65 8 0.08
57 INT147735 Regulation of Binding of PTK2 1 0.35 0.23 0.08
58 INT144400 Positive_regulation of Gene_expression of PTK2 33 0.70 21.24 0.06
59 INT225726 Positive_regulation of PXN 1 0.05 0.34 0.06
60 INT238187 Regulation of Positive_regulation of SRC 2 0.26 1.37 0.05
61 INT333217 Regulation of Positive_regulation of Ptk2 1 0.12 0.36 0.05
62 INT329775 Regulation of Regulation of PTK2 1 0.11 0.49 0.05
63 INT238180 Binding of Ptk2 5 0.35 2.99 0.04
64 INT327396 Positive_regulation of Negative_regulation of Ptk2 1 0.37 0.95 0.04
65 INT295374 Positive_regulation of Ptk2 1 0.34 0.06 0.04
66 INT198711 Binding of NCK1 1 0.05 1.08 0.03
67 INT238193 Regulation of Gene_expression of SRC 1 0.44 0 0.03
68 INT292474 Negative_regulation of Gene_expression of PTK2 8 0.41 5.17 0
69 INT283566 Localization of Ptk2 5 0.75 0.93 0
70 INT262779 Localization of PTK2 3 0.71 2.75 0
71 INT200683 Gene_expression of PTK2B 2 0.67 1.02 0
72 INT292478 Negative_regulation of Negative_regulation of PTK2 1 0.41 0.97 0
73 INT283564 Positive_regulation of Localization of Ptk2 1 0.47 0 0
74 INT309323 Positive_regulation of NCK1 1 0.01 0.06 0
75 INT329769 Positive_regulation of Localization of PTK2 1 0.17 1.42 0
76 INT243389 Transcription of PTK2B 1 0.64 0.52 0
77 INT295392 Positive_regulation of Localization of Ptk2 1 0.37 0 0
78 INT200665 Negative_regulation of Gene_expression of PTK2B 1 0.04 0.69 0
79 INT351669 Negative_regulation of Binding of Ptk2 1 0.40 0.73 0
80 INT295387 Localization of Ptk2 1 0.55 0 0
81 INT206472 Transcription of Ptk2 1 0.52 0.46 0
82 INT238159 Regulation of Binding of Ptk2 1 0.03 0.06 0
83 INT292481 Negative_regulation of Localization of PTK2 1 0.41 0.07 0
84 INT238185 Regulation of Binding of SRC 1 0.44 0.06 0
85 INT156922 Positive_regulation of Phosphorylation of PTK2B 1 0.23 0 0
86 INT329766 Positive_regulation of Positive_regulation of PTK2 1 0.11 0.51 0
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