GO:0007173

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Name epidermal growth factor receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0007173
Unique Molecular Interactions 2233
Total Molecular Interactions 2966
Total Single Events 22329
Pain Genes Associated 98

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for epidermal growth factor receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for epidermal growth factor receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
2 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
3 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
4 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
5 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
6 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
7 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
8 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 3 0.38 4.29 1.71
9 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
10 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
11 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63
12 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
13 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62
14 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
15 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
16 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
17 INT166676 Binding of PRKCA and UGT1A6 1 0.30 0 1.5
18 INT299311 Binding of RPTOR and RICTOR 1 0.38 0.21 1.4
19 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
20 INT299281 Binding of RPTOR and MAPKAP1 1 0.23 0.21 1.3
21 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
22 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
23 INT121000 Binding of PAG1 and Nrm 1 0.13 0.67 1.25
24 INT69562 Positive_regulation of AP2M1 Positive_regulation of Regulation of Adrb3 1 0.01 0.19 1.24
25 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
26 INT58140 Binding of AP2M1 and Oprm1 1 0.01 0.4 1.23
27 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
28 INT65203 OPRL1 Negative_regulation of ADCY1 1 0.19 0 1.19
29 INT75483 Binding of SGCG and TGFB1 1 0.52 2.27 1.19
30 INT142077 TGFB1 Negative_regulation of Binding of IDO1 1 0.15 2.07 1.19
31 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
32 INT220751 EGF Regulation of GOPC 1 0.08 0 1.18
33 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
34 INT220752 Negative_regulation of EGF Regulation of NAV1 1 0.26 0 1.18
35 INT220753 Negative_regulation of EGF Regulation of GOPC 1 0.08 0 1.18
36 INT220748 EGF Regulation of NAV1 1 0.28 0 1.17
37 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
38 INT65204 PNOC Negative_regulation of ADCY1 1 0.07 0 1.14
39 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
40 INT346986 Binding of SHC3 and PAG1 1 0.35 1.02 1.12
41 INT136989 EGF Negative_regulation of Positive_regulation of KCNJ2 1 0.04 1.09 1.1
42 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
43 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
44 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
45 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
46 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
47 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
48 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 0.40 0 1.05
49 INT97011 Binding of CALM3 and OPRM1 1 0.35 0 1.05
50 INT136988 EGF Negative_regulation of KCNJ2 1 0.04 1.09 1.04
51 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
52 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
53 INT144661 Dnm1 Negative_regulation of Binding of Hbegf 1 0.24 0 1.01
54 INT53052 ANTXRL Negative_regulation of Negative_regulation of ADCY1 1 0.01 0.66 0.99
55 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
56 INT69506 CA2 Positive_regulation of PRKCA 1 0.50 0.42 0.98
57 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
58 INT129206 RYBP Positive_regulation of Gene_expression of TGFB1 1 0.00 1.04 0.95
59 INT166790 HRAS Negative_regulation of Gene_expression of PTGER1 1 0.01 1.46 0.95
60 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
61 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
62 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
63 INT72213 Positive_regulation of PRKCA Regulation of Gene_expression of METTL3 1 0.05 0.17 0.93
64 INT72386 Egf Positive_regulation of Phosphorylation of Shc1 1 0.09 0.18 0.93
65 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
66 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92
67 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
68 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91
69 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
70 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
71 INT52114 Oprd1 Regulation of ADCY1 2 0.05 0.46 0.9
72 INT220744 EGF Positive_regulation of Gene_expression of KRT20 1 0.01 1.26 0.9
73 INT121702 HRAS Negative_regulation of Positive_regulation of MMP1 1 0.06 0.2 0.9
74 INT121701 HRAS Negative_regulation of MMP1 1 0.06 0.2 0.89
75 INT121704 HRAS Negative_regulation of MMP3 1 0.06 0.19 0.89
76 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
77 INT121699 HRAS Negative_regulation of Gene_expression of MMP1 1 0.06 0.19 0.88
78 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
79 INT149559 Tgfb1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0 0.88
80 INT149562 Tgfb1 Positive_regulation of CXCL10 1 0.00 0 0.88
81 INT149564 Tgfb1 Positive_regulation of Gene_expression of CXCL10 1 0.00 0 0.88
82 INT149560 Tgfb1 Positive_regulation of Ccr5 1 0.00 0 0.88
83 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
84 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
85 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87
86 INT52390 OPRD1 Regulation of ADCY1 1 0.09 0.13 0.86
87 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 0.02 0.05 0.85
88 INT114323 Binding of ADCY6 and RAF1 1 0.02 0.05 0.85
89 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
90 INT222985 CP Positive_regulation of Positive_regulation of TGFB1 1 0.00 1.57 0.85
91 INT80877 Negative_regulation of PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84
92 INT80878 PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84
93 INT149561 Tgfb1 Positive_regulation of Gene_expression of CCL2 1 0.00 0 0.83
94 INT220739 EGF Positive_regulation of Transcription of NAV1 1 0.31 0.16 0.83
95 INT149563 Tgfb1 Positive_regulation of CCL2 1 0.00 0 0.83
96 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
97 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82
98 INT149558 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.00 0 0.82
99 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82
100 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
101 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 0.00 0 0.82
102 INT84039 EGF Positive_regulation of Gene_expression of CPOX 2 0.11 1.88 0.8
103 INT84040 EGF Positive_regulation of CPOX 2 0.07 1.91 0.8
104 INT322397 Egfr Positive_regulation of Adarb1 1 0.00 0.08 0.8
105 INT220747 Binding of PCa and EGF 1 0.05 1.42 0.8
106 INT42797 Egf Regulation of Gene_expression of Penk 1 0.21 0.07 0.8
107 INT108331 EGF Positive_regulation of Phosphorylation of BAD 1 0.49 6.72 0.8
108 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
109 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
110 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 0.47 1.21 0.77
111 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
112 INT161483 Slc7a12 Regulation of Gene_expression of TGFB1 1 0.14 1.21 0.77
113 INT124384 ADRBK1 Negative_regulation of MC1R 1 0.40 0.42 0.77
114 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77
115 INT231031 Egf Positive_regulation of Sec22b 1 0.03 0.05 0.76
116 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
117 INT65593 CALCA Negative_regulation of Positive_regulation of ADCY1 1 0.23 0.07 0.76
118 INT161482 Il1b Negative_regulation of TGFB1 1 0.45 1.17 0.76
119 INT166674 YY1 Regulation of Binding of PRKCA 1 0.38 0 0.75
120 INT309735 Binding of CALM3 and TRPV4 1 0.14 0 0.75
121 INT133675 NPY6R Negative_regulation of SRC 1 0.17 0.75 0.74
122 INT161484 Binding of TGFB1 and Il1b 1 0.37 1.16 0.73
123 INT220746 EGF Positive_regulation of Gene_expression of GOPC 1 0.13 0 0.72
124 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
125 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
126 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
127 INT104301 Adam17 Regulation of Negative_regulation of Sell 1 0.39 0.58 0.69
128 INT166673 PRKCA Negative_regulation of UGT1A6 1 0.36 0 0.69
129 INT140235 ADRBK1 Positive_regulation of Binding of MC1R 1 0.46 0.31 0.68
130 INT302642 Binding of ARSA and TGFB1 1 0.05 0.28 0.68
131 INT140237 Gene_expression of ADRBK1 Positive_regulation of Gene_expression of MC1R 1 0.46 0.31 0.68
132 INT74599 YY1 Negative_regulation of ADCY1 2 0.36 0.31 0.67
133 INT121966 HRAS Positive_regulation of RAC1 1 0.75 0.41 0.67
134 INT354913 VDR Positive_regulation of TGFB1 1 0.05 1.33 0.67
135 INT299989 PRKCA Positive_regulation of Gene_expression of IL8 1 0.04 0.45 0.67
136 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
137 INT169213 Binding of EGFR and CARTPT 1 0.00 0.22 0.67
138 INT189704 PRKCA Regulation of CHKB 1 0.13 0.18 0.66
139 INT249489 Src Negative_regulation of Phosphorylation of Grin2b 1 0.20 0.63 0.66
140 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
141 INT266064 Binding of PAG1 and Creb1 1 0.04 1.52 0.65
142 INT184193 HRAS Negative_regulation of Gene_expression of IL1B 1 0.00 1.12 0.65
143 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
144 INT169293 PTPLA Positive_regulation of AKT1 1 0.10 0.15 0.64
145 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
146 INT266065 Positive_regulation of Binding of Ceacam3 and PAG1 1 0.03 1.44 0.63
147 INT266062 Binding of Ceacam3 and PAG1 1 0.02 1.44 0.63
148 INT337323 KNG1 Positive_regulation of PRKCA 1 0.15 0.17 0.62
149 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62
150 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
151 INT247285 GLC1N Positive_regulation of Gene_expression of HRAS 1 0.02 1.3 0.61
152 INT137017 Tgfb1 Positive_regulation of Gene_expression of Acta2 1 0.00 0.84 0.61
153 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
154 INT169287 EGF Positive_regulation of Localization of IL8 1 0.15 0.13 0.61
155 INT169294 EGF Positive_regulation of Localization of IL6 1 0.18 0.13 0.61
156 INT113962 OPRM1 Regulation of CREB1 1 0.39 0.31 0.6
157 INT65014 SOS1 Positive_regulation of Gene_expression of IL6 1 0.45 0.42 0.6
158 INT81606 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TACR1 1 0.29 0 0.6
159 INT54942 Rb1 Regulation of Gab1 1 0.02 0.39 0.59
160 INT275063 CA2 Positive_regulation of Positive_regulation of CAMK4 1 0.01 0 0.59
161 INT100225 Binding of Egf and Src 1 0.01 0.67 0.58
162 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
163 INT199976 EGF Regulation of ITGB3BP 1 0.02 0.77 0.57
164 INT81605 PRKCA Positive_regulation of Phosphorylation of TACR1 1 0.43 0 0.57
165 INT169286 CNR1 Positive_regulation of Phosphorylation of EGFR 1 0.45 0.18 0.57
166 INT335995 Il10 Negative_regulation of Tgfb1 1 0.06 0.83 0.57
167 INT56088 TGFB1 Positive_regulation of Transcription of SERPINE1 1 0.46 0.83 0.57
168 INT190181 Positive_regulation of PIK3CA Positive_regulation of MMP12 1 0.01 0.54 0.56
169 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
170 INT323148 PRKCA Positive_regulation of RAF1 1 0.01 0 0.55
171 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55
172 INT210830 OPRM1 Negative_regulation of ADCY1 1 0.00 0.06 0.55
173 INT302645 ARSA Positive_regulation of Gene_expression of TGFB1 1 0.08 0.28 0.55
174 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
175 INT121993 Binding of EGF and SGCG 1 0.40 0 0.55
176 INT201944 CXCL10 Positive_regulation of Phosphorylation of AKT1 1 0.09 0.79 0.55
177 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
178 INT323150 PRKCA Positive_regulation of Phosphorylation of RAF1 1 0.01 0 0.55
179 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
180 INT64744 OR5D2P Negative_regulation of ADCY1 1 0.00 0 0.54
181 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
182 INT89144 TGFB1 Regulation of Gene_expression of Tcstv1 1 0.00 0.53 0.53
183 INT85125 IL3 Positive_regulation of MAPK1 1 0.30 0.81 0.53
184 INT85121 CSF2 Positive_regulation of MAPK1 1 0.07 0.8 0.53
185 INT85115 IL5 Positive_regulation of MAPK1 1 0.14 0.81 0.53
186 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
187 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
188 INT92918 Atp6v0a2 Negative_regulation of Gene_expression of Tgfb1 1 0.01 0.83 0.52
189 INT106392 ADRBK1 Regulation of Negative_regulation of OPRL1 1 0.27 0.06 0.52
190 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
191 INT201939 CXCL10 Positive_regulation of MAPK1 1 0.11 0.72 0.52
192 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
193 INT120383 PRKCD Positive_regulation of Localization of EPHB2 1 0.29 0.42 0.52
194 INT220745 EGF Positive_regulation of Positive_regulation of PCa 1 0.05 0.79 0.52
195 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
196 INT122872 SEMA6A Positive_regulation of MAPK1 1 0.56 0 0.52
197 INT97949 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of CDC42 1 0.06 0.72 0.51
198 INT131368 MAPK1 Positive_regulation of Bcar3 1 0.00 0.37 0.51
199 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51
200 INT120384 PRKCD Positive_regulation of Localization of HSPG2 1 0.29 0.42 0.51

Single Events

The table below shows the top 100 pain related interactions that have been reported for epidermal growth factor receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in epidermal growth factor receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT81417 Gene_expression of PAG1 94 0.58 90.85 92.79
2 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
3 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88
4 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
5 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9
6 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18
7 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
8 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
9 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47
10 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
11 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
12 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
13 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
14 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64
15 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
16 INT254567 Positive_regulation of Gene_expression of PAG1 10 0.39 31.15 24.26
17 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
18 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23
19 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2
20 INT11157 Binding of EGF 88 0.48 53.73 21.25
21 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78
22 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41
23 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
24 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
25 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
26 INT99058 Regulation of PAG1 18 0.45 21.62 18.5
27 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
28 INT12081 Localization of TGFB1 64 0.81 35.4 17.47
29 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79
30 INT12617 Regulation of ADCY1 41 0.61 7.38 15.94
31 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
32 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47
33 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
34 INT63553 Binding of PAG1 14 0.48 12.51 14.76
35 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
36 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
37 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68
38 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66
39 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
40 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18
41 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
42 INT13823 Gene_expression of Egf 97 0.78 39.99 12.99
43 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
44 INT118905 Positive_regulation of Positive_regulation of PAG1 8 0.40 7.55 12.25
45 INT11429 Gene_expression of ADCY1 26 0.74 5.89 11.93
46 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
47 INT72221 Localization of PRKCA 17 0.81 1.23 11.47
48 INT40486 Positive_regulation of Positive_regulation of ADCY1 20 0.48 4.29 11.33
49 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
50 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
51 INT12620 Negative_regulation of Negative_regulation of ADCY1 16 0.44 2.98 10.1
52 INT254566 Negative_regulation of Gene_expression of PAG1 7 0.33 9.51 9.91
53 INT2036 Localization of EGF 42 0.77 21.5 9.74
54 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42
55 INT54588 Positive_regulation of CREB1 38 0.67 12.01 9.18
56 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
57 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
58 INT22771 Positive_regulation of Egf 44 0.70 16.45 8.64
59 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57
60 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
61 INT54681 Negative_regulation of Positive_regulation of ADCY1 16 0.38 2.7 8.14
62 INT81419 Localization of PAG1 10 0.64 11.1 8.01
63 INT87271 Positive_regulation of Phosphorylation of CREB1 27 0.66 12.87 7.91
64 INT81345 Gene_expression of ADRBK1 21 0.70 2.89 7.9
65 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
66 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
67 INT75526 Positive_regulation of Positive_regulation of PRKCA 16 0.50 4.34 7.46
68 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
69 INT86867 Regulation of CREB1 15 0.46 4.95 7.28
70 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27
71 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93
72 INT2037 Negative_regulation of EGF 30 0.59 15.05 6.81
73 INT72222 Positive_regulation of Localization of PRKCA 8 0.70 0.55 6.56
74 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41
75 INT13822 Localization of Egf 30 0.81 13.79 6.4
76 INT92716 Negative_regulation of PAG1 6 0.51 5.82 6.32
77 INT11154 Binding of EGFR 149 0.48 96.23 6.29
78 INT38595 Localization of BCAR1 8 0.73 2.9 6.25
79 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
80 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
81 INT6667 Gene_expression of CREB1 27 0.77 6.29 5.84
82 INT97018 Binding of CALM3 7 0.43 0.13 5.82
83 INT26919 Gene_expression of ITPR3 47 0.42 5.86 5.79
84 INT254570 Regulation of Gene_expression of PAG1 3 0.35 6.72 5.76
85 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61
86 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54
87 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47
88 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
89 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
90 INT100222 Binding of Src 9 0.26 5.41 5.37
91 INT95120 Positive_regulation of CASP9 76 0.67 67.55 5.33
92 INT80881 Phosphorylation of ADCY1 7 0.69 1.22 5.29
93 INT48200 Transcription of Tgfb1 13 0.69 3.85 5.24
94 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23
95 INT37227 Regulation of EGF 19 0.45 11.16 5.17
96 INT70800 Negative_regulation of Positive_regulation of PRKCA 9 0.34 2.18 5.17
97 INT67868 Negative_regulation of Gene_expression of Tgfb1 18 0.43 14.27 5.16
98 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15
99 INT89104 Binding of TGFB1 29 0.44 13.67 5.12
100 INT26334 Localization of ITPR3 39 0.49 2.53 5.07
101 INT21901 Negative_regulation of Egf 25 0.58 10.46 4.99
102 INT89844 Positive_regulation of Phosphorylation of Src 10 0.43 4.71 4.95
103 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93
104 INT100220 Negative_regulation of Src 13 0.41 6.37 4.93
105 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
106 INT166678 Negative_regulation of Phosphorylation of PRKCA 12 0.38 5.77 4.59
107 INT1807 Negative_regulation of Bcar1 9 0.38 4.04 4.59
108 INT71716 Binding of Hbegf 21 0.28 6.54 4.51
109 INT104299 Negative_regulation of Adam17 18 0.47 12.03 4.39
110 INT14574 Positive_regulation of Negative_regulation of ADCY1 9 0.66 2.45 4.39
111 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37
112 INT103914 Phosphorylation of Egfr 35 0.82 16.98 4.31
113 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28
114 INT20981 Binding of HRAS 42 0.48 24.49 4.23
115 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
116 INT105171 Phosphorylation of RAF1 11 0.74 2.33 4.19
117 INT65926 Positive_regulation of Gene_expression of Egf 26 0.70 12.91 4.18
118 INT36335 Localization of Tgfb1 19 0.79 7.06 4.17
119 INT23653 Binding of Egf 22 0.36 11.34 4.12
120 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02
121 INT57157 Gene_expression of TDGF1 5 0.75 3.97 4.02
122 INT69681 Negative_regulation of Tgfb1 42 0.51 22.28 4
123 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
124 INT80175 Positive_regulation of Gene_expression of HRAS 24 0.67 14.69 3.97
125 INT100741 Positive_regulation of ADRBK1 10 0.64 1.01 3.95
126 INT169475 Localization of HRAS 14 0.73 9.02 3.9
127 INT120715 Positive_regulation of Egfr 15 0.68 5.53 3.77
128 INT26191 Positive_regulation of ITPR3 24 0.44 1.9 3.74
129 INT87408 Negative_regulation of ADCY2 3 0.01 0.1 3.68
130 INT119506 Negative_regulation of Egfr 32 0.55 23.75 3.67
131 INT31758 Positive_regulation of Egf 32 0.66 19.42 3.64
132 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6
133 INT122327 Regulation of Src 6 0.59 0.59 3.6
134 INT18920 Binding of Egf 24 0.48 9.43 3.57
135 INT51848 Transcription of TGFB1 17 0.69 9.57 3.53
136 INT56300 Negative_regulation of Gene_expression of TGFB1 13 0.41 4.87 3.5
137 INT8096 Positive_regulation of Gene_expression of EGF 21 0.69 13.43 3.47
138 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45
139 INT87281 Localization of ADCY1 7 0.64 1.84 3.42
140 INT260159 Negative_regulation of Positive_regulation of PAG1 2 0.33 1.86 3.39
141 INT119421 Negative_regulation of RAF1 10 0.41 6.94 3.31
142 INT69216 Positive_regulation of Tgfb1 14 0.49 5.84 3.29
143 INT192450 Gene_expression of CLTC 26 0.55 18.82 3.26
144 INT72216 Regulation of Positive_regulation of PRKCA 9 0.37 1.36 3.26
145 INT85147 Positive_regulation of Gene_expression of Tgfb1 12 0.46 7.29 3.24
146 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23
147 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
148 INT85149 Negative_regulation of Gene_expression of Tgfb1 11 0.42 4.73 3.19
149 INT71717 Negative_regulation of Hbegf 15 0.39 3.63 3.18
150 INT53495 Negative_regulation of Negative_regulation of PRKCA 4 0.42 2.37 3.18
151 INT11015 Regulation of Phosphorylation of CREB1 4 0.46 1.45 3.17
152 INT124954 Gene_expression of Egfr 26 0.75 15.08 3.12
153 INT120562 Negative_regulation of Egfr 108 0.59 79.38 3.11
154 INT117348 Regulation of EGFR 75 0.61 47.73 3.09
155 INT100688 Gene_expression of SRC 28 0.75 15.51 3.08
156 INT13179 Regulation of Positive_regulation of ADCY1 5 0.34 0.89 3.08
157 INT77333 Binding of Hbegf 5 0.32 2.39 3.07
158 INT38594 Positive_regulation of Localization of BCAR1 3 0.63 0.44 3.07
159 INT192676 Binding of PTEN 14 0.46 10.58 3.06
160 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
161 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
162 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
163 INT59309 Negative_regulation of Gene_expression of ADCY1 3 0.42 1.04 2.98
164 INT112667 Negative_regulation of Tgfb1 9 0.58 2.72 2.97
165 INT31757 Negative_regulation of Egf 18 0.41 9.7 2.94
166 INT9130 Negative_regulation of TGFB1 16 0.41 12.21 2.92
167 INT102969 Positive_regulation of Gene_expression of ADRBK1 7 0.46 1.21 2.87
168 INT117785 Regulation of Gene_expression of EGF 7 0.44 4.22 2.87
169 INT69641 Positive_regulation of ADCY2 5 0.32 0.18 2.87
170 INT102157 Gene_expression of Adam17 3 0.58 4.17 2.86
171 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83
172 INT19235 Negative_regulation of PDE1B 11 0.14 2.38 2.81
173 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8
174 INT30815 Binding of ADCY1 7 0.36 0.21 2.79
175 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78
176 INT48199 Regulation of Tgfb1 17 0.54 9.57 2.74
177 INT171682 Positive_regulation of Phosphorylation of PRKCA 3 0.43 1.04 2.72
178 INT110503 Negative_regulation of ADRBK1 4 0.53 0.71 2.69
179 INT62683 Negative_regulation of HRAS 19 0.57 7.93 2.65
180 INT80884 Positive_regulation of Phosphorylation of ADCY1 4 0.43 0.24 2.64
181 INT87340 Negative_regulation of BCAR1 8 0.38 6.96 2.63
182 INT98919 Negative_regulation of Phosphorylation of CREB1 8 0.58 2.4 2.63
183 INT11426 Positive_regulation of Gene_expression of ADCY1 5 0.29 0.68 2.63
184 INT176531 Gene_expression of SHC1 3 0.67 9.5 2.62
185 INT28878 Negative_regulation of Localization of Egf 6 0.49 10.34 2.57
186 INT77636 Phosphorylation of Egf 11 0.61 1.69 2.56
187 INT91825 Binding of HBEGF 4 0.31 2.39 2.52
188 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5
189 INT99548 Positive_regulation of Gene_expression of CDKN1B 12 0.67 6.79 2.5
190 INT4435 Gene_expression of PIK3C2A 20 0.77 14.43 2.48
191 INT48198 Binding of Tgfb1 29 0.47 19.59 2.46
192 INT108333 Phosphorylation of BAD 43 0.68 33.77 2.45
193 INT61378 Positive_regulation of Bcar1 13 0.45 2.84 2.45
194 INT26918 Positive_regulation of Gene_expression of ITPR3 14 0.27 2.31 2.41
195 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
196 INT114327 Positive_regulation of RAF1 26 0.51 20.87 2.32
197 INT186116 Regulation of Gene_expression of MAPK1 9 0.44 5.85 2.32
198 INT29402 Gene_expression of Src 16 0.74 4.57 2.29
199 INT143247 Positive_regulation of CAMK4 9 0.67 5.25 2.28
200 INT26335 Binding of ITPR3 22 0.18 3.3 2.27
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