GO:0007175

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Name negative regulation of epidermal growth factor-activated receptor activity
Categary Process
Go Slim No
Go Link GO:0007175
Unique Molecular Interactions 55
Total Molecular Interactions 76
Total Single Events 807
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of epidermal growth factor-activated receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of epidermal growth factor-activated receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
2 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
3 INT319312 Socs4 Positive_regulation of Mapk8 1 0.05 0.68 0.41
4 INT319308 Socs4 Positive_regulation of Prkca 1 0.05 0.67 0.41
5 INT319313 Socs4 Positive_regulation of Mapk14 1 0.02 0.68 0.41
6 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
7 INT184086 Socs5 Negative_regulation of Binding of Jak1 1 0.20 0 0.16
8 INT184098 Binding of Il4 and Socs5 1 0.09 2.05 0.15
9 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
10 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
11 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
12 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
13 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
14 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
15 INT193967 Binding of PSEN1 and Psen1 1 0.41 1.2 0.05
16 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05
17 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
18 INT331477 PSEN2 Regulation of Gene_expression of Psen1 1 0.00 0.15 0.03
19 INT354896 Binding of Psen2 and Fancd2 1 0.04 0.75 0.03
20 INT181079 Binding of Akt1 and Errfi1 1 0.00 0.8 0.03
21 INT331478 Psen1 Regulation of Gene_expression of PSEN2 1 0.00 0.15 0.03
22 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
23 INT193962 Binding of Psen1 and Ncstn 1 0.13 0.08 0
24 INT334644 Binding of PSEN1 and TTN 1 0.01 0 0
25 INT350098 Gene_expression of PSEN2 Positive_regulation of Gene_expression of Hmox1 1 0.39 0 0
26 INT273289 Binding of Psen2 and Ryr2 1 0.27 4.53 0
27 INT184137 Binding of Socs5 and Regulation of Hand2 1 0.09 1.01 0
28 INT181078 Binding of Errfi1 and Cdc42ep3 1 0.00 0.73 0
29 INT217398 Binding of Psen2 and Bace1 1 0.12 1.44 0
30 INT193955 Binding of Psen1 and Psen2 1 0.37 1.64 0
31 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
32 INT286331 Binding of Psen1 and Ror1 1 0.27 0 0
33 INT193968 Binding of PSEN1 and Ps 1 0.07 0.66 0
34 INT262712 Psen1 Regulation of Gene_expression of Bace1 1 0.22 0.07 0
35 INT217400 Binding of Psen1 and Bace1 1 0.17 1.43 0
36 INT286337 PSENEN Regulation of Psen1 1 0.07 0.37 0
37 INT193958 Binding of Pld1 and Psen1 1 0.17 0 0
38 INT193953 Binding of Bcl2l1 and Psen1 1 0.07 0.66 0
39 INT193956 Binding of Psen1 and Rab6a 1 0.15 0 0
40 INT294428 PSEN2 Regulation of Gene_expression of Tp53 1 0.49 0.86 0
41 INT294429 PSEN2 Negative_regulation of Tp53 1 0.46 1.03 0
42 INT193957 Binding of Bcl2l1 and Psen2 1 0.07 0.66 0
43 INT331479 Binding of PSEN2 and Psen1 1 0.00 0.07 0
44 INT234221 Negative_regulation of PSEN1 Negative_regulation of Gene_expression of APP 1 0.33 0.32 0
45 INT181085 Binding of Cdc42 and Errfi1 1 0.08 0.67 0
46 INT334645 Binding of PSEN1 and HM13 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of epidermal growth factor-activated receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of epidermal growth factor-activated receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
2 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
3 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
4 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
5 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
6 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
7 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
8 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
9 INT163544 Binding of Psen1 40 0.36 15.28 2.42
10 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
11 INT60723 Localization of Psen2 5 0.68 2.11 2.02
12 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
13 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
14 INT319253 Regulation of Socs4 1 0.05 2.9 1.66
15 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
16 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
17 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
18 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
19 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
20 INT319251 Positive_regulation of Socs4 1 0.07 1.48 0.84
21 INT78647 Positive_regulation of Localization of Psen2 1 0.16 0.14 0.83
22 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
23 INT94756 Positive_regulation of PSEN2 8 0.49 4.59 0.77
24 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
25 INT193849 Positive_regulation of Gene_expression of Psen2 5 0.44 4.92 0.76
26 INT78649 Binding of Psen2 7 0.36 5.9 0.73
27 INT78648 Regulation of Binding of Psen2 1 0.14 0.2 0.73
28 INT184019 Gene_expression of Socs5 6 0.53 4.94 0.72
29 INT319270 Localization of Socs4 1 0.08 2.1 0.66
30 INT91765 Positive_regulation of Gene_expression of PSEN2 8 0.49 4.57 0.63
31 INT319296 Gene_expression of Socs4 1 0.07 2.01 0.6
32 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53
33 INT316041 Transcription of Psen2 1 0.64 1.1 0.45
34 INT234249 Regulation of PSEN1 6 0.37 2.21 0.43
35 INT234257 Regulation of Gene_expression of PSEN1 6 0.44 1.98 0.42
36 INT193856 Localization of Psen1 19 0.73 9.79 0.41
37 INT36396 Positive_regulation of Psen2 6 0.44 4.57 0.39
38 INT177773 Localization of PSEN1 4 0.73 0.89 0.36
39 INT261682 Positive_regulation of Positive_regulation of PSEN2 1 0.21 0.55 0.33
40 INT224298 Negative_regulation of PSEN2 6 0.57 2.29 0.28
41 INT85329 Regulation of Errfi1 1 0.01 0.39 0.28
42 INT316045 Negative_regulation of Negative_regulation of Psen1 1 0.42 1.58 0.27
43 INT261676 Negative_regulation of Positive_regulation of PSEN1 1 0.36 1.59 0.25
44 INT172525 Localization of PSEN2 5 0.73 4.17 0.24
45 INT181508 Regulation of Regulation of Psen1 2 0.33 0.51 0.2
46 INT286317 Positive_regulation of Transcription of Psen1 1 0.37 0.32 0.17
47 INT319265 Positive_regulation of Gene_expression of Socs4 1 0.05 0.18 0.16
48 INT336359 Positive_regulation of Phosphorylation of Psen1 1 0.33 0.4 0.13
49 INT336361 Phosphorylation of Psen1 1 0.54 0.34 0.13
50 INT176595 Negative_regulation of Gene_expression of PSEN2 1 0.24 1.01 0.11
51 INT193841 Regulation of Gene_expression of Psen2 1 0.40 1.66 0.11
52 INT319279 Negative_regulation of Gene_expression of Socs4 1 0.04 1.35 0.11
53 INT201694 Negative_regulation of Gene_expression of PSEN1 3 0.41 2.31 0.1
54 INT273285 Negative_regulation of Localization of Psen1 1 0.36 0.99 0.09
55 INT109131 Regulation of PSEN2 3 0.44 0.55 0.08
56 INT193862 Positive_regulation of Positive_regulation of Psen1 3 0.49 0.9 0.08
57 INT193872 Positive_regulation of Localization of Psen1 3 0.49 1.39 0.08
58 INT261678 Positive_regulation of Positive_regulation of PSEN1 1 0.42 0.62 0.08
59 INT193890 Regulation of Positive_regulation of Psen1 1 0.44 0.66 0.08
60 INT193938 Phosphorylation of PSEN1 5 0.79 1.6 0.07
61 INT226391 Positive_regulation of Gene_expression of Socs5 1 0.11 0.81 0.07
62 INT176592 Transcription of PSEN2 5 0.33 0.41 0.05
63 INT193859 Negative_regulation of Binding of Psen1 3 0.42 1.85 0.05
64 INT331406 Negative_regulation of Regulation of Psen1 1 0.04 0.09 0.05
65 INT193865 Protein_catabolism of Psen1 10 0.97 0.37 0.04
66 INT224302 Negative_regulation of Transcription of PSEN2 3 0.26 0.08 0
67 INT265229 Binding of PSEN2 2 0.16 1.37 0
68 INT286327 Regulation of Binding of Psen1 1 0.33 0.16 0
69 INT234250 Positive_regulation of Negative_regulation of PSEN1 1 0.41 0 0
70 INT193886 Regulation of Protein_catabolism of Psen1 1 0.44 0.06 0
71 INT193934 Positive_regulation of Binding of PSEN1 1 0.49 0.92 0
72 INT224297 Regulation of Transcription of PSEN2 1 0.20 0.06 0
73 INT331407 Negative_regulation of Transcription of Psen1 1 0.04 0.08 0
74 INT177774 Transcription of PSEN1 1 0.33 0.09 0
75 INT354892 Negative_regulation of Psen2 1 0.37 0.95 0
76 INT193844 Positive_regulation of Protein_catabolism of Psen1 1 0.49 0.05 0
77 INT331463 Regulation of Gene_expression of PSEN2 1 0.04 0 0
78 INT234258 Negative_regulation of Phosphorylation of PSEN1 1 0.35 0.49 0
79 INT184034 Binding of Socs5 1 0.24 2.05 0
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