GO:0007178

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Name transmembrane receptor protein serine/threonine kinase signaling pathway
Categary Process
Go Slim No
Go Link GO:0007178
Unique Molecular Interactions 44
Total Molecular Interactions 70
Total Single Events 296
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for transmembrane receptor protein serine/threonine kinase signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for transmembrane receptor protein serine/threonine kinase signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
2 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
3 INT316690 Binding of Myd88 and Il1 2 0.06 1.75 0.66
4 INT171897 Binding of Bmpr2 and Il1 1 0.03 0.84 0.52
5 INT81991 Bmpr2 Positive_regulation of Gene_expression of ODF1 1 0.03 1.59 0.41
6 INT75489 Binding of SGCG and Tgfbr2 1 0.23 0.83 0.41
7 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41
8 INT194860 BMPR2 Positive_regulation of IL1B 1 0.01 0.61 0.34
9 INT324825 Binding of Chuk and Myd88 1 0.03 0.86 0.28
10 INT288205 Binding of Cd14 and Myd88 1 0.10 0.57 0.28
11 INT324806 Positive_regulation of Binding of Chuk and Myd88 1 0.04 0.86 0.28
12 INT256063 Myd88 Positive_regulation of Gene_expression of Mcpt1 1 0.13 0.56 0.27
13 INT254219 Binding of Myd88 and Tlr2 2 0.16 0.6 0.2
14 INT179504 Tlr4 Regulation of Myd88 1 0.07 0.29 0.17
15 INT254214 Binding of Myd88 and Tirap 1 0.15 0.55 0.17
16 INT251347 Binding of Bmpr2 and Limk1 1 0.18 1.51 0.16
17 INT278373 Myd88 Regulation of Phosphorylation of Syk 1 0.15 0.35 0.15
18 INT278394 Myd88 Regulation of Phosphorylation of Hps5 1 0.11 0.35 0.15
19 INT193693 Binding of Myd88 and Pain1 1 0.14 0.82 0.13
20 INT254201 Myd88 Positive_regulation of Ik 1 0.00 0.14 0.12
21 INT334266 Binding of Irak1 and Myd88 2 0.35 0.16 0.09
22 INT335771 MIR155 Regulation of IRAK1 1 0.04 0.29 0.09
23 INT350073 Binding of co and Myd88 1 0.00 0.17 0.08
24 INT189550 Binding of BMPR2 and PAH 1 0.06 2.68 0.08
25 INT254223 Tlr3 Positive_regulation of Myd88 1 0.16 0.23 0.08
26 INT350481 Tlr4 Positive_regulation of Gene_expression of Myd88 1 0.26 0.06 0.06
27 INT334260 Negative_regulation of Binding of Myd88 and Il1 1 0.01 0.4 0.06
28 INT334258 Binding of Myd88 and Irak4 2 0.26 0.24 0.05
29 INT334262 Myd88 Positive_regulation of Tlr7 1 0.05 0.3 0.04
30 INT238008 Myd88 Regulation of Hand1 1 0.03 0.82 0.04
31 INT319218 Bmpr2 Negative_regulation of Smad2 1 0.17 0.12 0.03
32 INT319219 Bmpr2 Positive_regulation of Smad1 1 0.18 0.29 0.03
33 INT319217 Bmpr2 Positive_regulation of Gene_expression of Smad1 1 0.19 0.11 0.03
34 INT299006 Binding of Il18 and Myd88 1 0.21 0.19 0.03
35 INT205409 Binding of BMP6 and BMPR2 1 0.07 0.05 0
36 INT350077 Negative_regulation of Binding of Myd88 and Tlr4 1 0.12 0.16 0
37 INT348039 Binding of Myd88 and Irak2 1 0.22 0 0
38 INT310186 Binding of Gdf2 and Bmpr2 1 0.02 0 0
39 INT205452 Binding of BMP6 and Acvr2a 1 0.03 0.05 0
40 INT205451 Binding of BMP2 and Acvr2a 1 0.02 0.05 0
41 INT324696 Binding of Myd88 and Mapk10 1 0.05 0.68 0
42 INT205410 Binding of BMP2 and BMPR2 1 0.07 0.05 0
43 INT310187 Acvrl1 Regulation of Gene_expression of Bmpr2 1 0.04 0 0
44 INT295571 Binding of Acvr2b and Mstn 1 0.08 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for transmembrane receptor protein serine/threonine kinase signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in transmembrane receptor protein serine/threonine kinase signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT197491 Gene_expression of Myd88 32 0.74 14.59 5.29
2 INT142752 Positive_regulation of Myd88 26 0.66 12.07 4.4
3 INT142754 Binding of Myd88 20 0.36 9.61 3.8
4 INT75485 Gene_expression of Tgfbr2 10 0.57 10.98 3.76
5 INT132773 Negative_regulation of Acvr2b 3 0.41 1.55 2.87
6 INT233975 Positive_regulation of Gene_expression of Myd88 7 0.66 4.17 1.65
7 INT81982 Gene_expression of Bmpr2 36 0.60 14.58 1.55
8 INT246928 Negative_regulation of Myd88 12 0.38 6.16 1.3
9 INT233970 Regulation of Myd88 7 0.45 5.2 1.28
10 INT250171 Localization of Myd88 4 0.72 1.95 0.88
11 INT334226 Positive_regulation of Localization of Myd88 1 0.36 0.54 0.67
12 INT233973 Negative_regulation of Gene_expression of Myd88 4 0.38 1.32 0.61
13 INT323751 Gene_expression of IRAK1 3 0.44 1.33 0.6
14 INT110924 Regulation of BMPR2 3 0.17 1.75 0.54
15 INT218293 Gene_expression of Acvr2b 14 0.76 4.22 0.44
16 INT323739 Regulation of IRAK1 3 0.23 1.73 0.43
17 INT270000 Localization of IRAK1 3 0.73 0.82 0.43
18 INT343891 Positive_regulation of Gene_expression of IRAK1 1 0.23 0.3 0.42
19 INT120899 Positive_regulation of Gene_expression of Tgfbr2 1 0.29 0.46 0.38
20 INT256056 Positive_regulation of Binding of Myd88 2 0.48 0.36 0.36
21 INT150330 Gene_expression of BMPR2 7 0.29 4.22 0.34
22 INT251324 Binding of Bmpr2 5 0.23 2.99 0.34
23 INT201967 Positive_regulation of Bmpr2 4 0.31 1.24 0.34
24 INT197492 Regulation of Gene_expression of Myd88 2 0.39 1.95 0.27
25 INT251327 Regulation of Binding of Bmpr2 1 0.20 2.27 0.27
26 INT81981 Negative_regulation of Bmpr2 4 0.27 2.88 0.21
27 INT150332 Negative_regulation of Gene_expression of BMPR2 1 0.01 0 0.2
28 INT150331 Positive_regulation of Gene_expression of BMPR2 2 0.02 0.59 0.19
29 INT123935 Positive_regulation of BMPR2 3 0.26 1.65 0.18
30 INT233971 Transcription of Myd88 2 0.60 1.01 0.17
31 INT189604 Negative_regulation of BMPR2 2 0.26 0.95 0.15
32 INT192082 Localization of BMPR2 1 0.32 0.55 0.15
33 INT166623 Binding of BMPR2 1 0.29 0.35 0.13
34 INT323746 Phosphorylation of IRAK1 1 0.46 0.81 0.12
35 INT334237 Negative_regulation of Binding of Myd88 1 0.30 1.16 0.12
36 INT323732 Regulation of Gene_expression of IRAK1 1 0.26 0.82 0.12
37 INT306310 Positive_regulation of Positive_regulation of Myd88 1 0.38 0.41 0.12
38 INT335789 Negative_regulation of Transcription of IRAK1 1 0.22 0.45 0.11
39 INT335817 Transcription of IRAK1 1 0.35 0.45 0.11
40 INT335806 Negative_regulation of IRAK1 1 0.30 0.36 0.1
41 INT201962 Transcription of Bmpr2 6 0.37 3.51 0.09
42 INT334227 Positive_regulation of Regulation of Myd88 1 0.36 0.63 0.08
43 INT254332 Negative_regulation of Gene_expression of Bmpr2 3 0.22 2.41 0.07
44 INT278039 Phosphorylation of BMPR2 1 0.08 0.26 0.03
45 INT278022 Phosphorylation of Bmpr2 1 0.21 0.27 0.03
46 INT302312 Localization of Bmpr2 4 0.46 0.47 0
47 INT219929 Positive_regulation of Gene_expression of Bmpr2 3 0.15 0.9 0
48 INT218291 Positive_regulation of Gene_expression of Acvr2b 1 0.49 0.55 0
49 INT319209 Regulation of Positive_regulation of Bmpr2 1 0.28 0.08 0
50 INT189623 Transcription of BMPR2 1 0.32 0.71 0
51 INT355333 Regulation of Transcription of Bmpr2 1 0.03 0.15 0
52 INT310177 Binding of Tgfbr2 1 0.24 0 0
53 INT218282 Regulation of Acvr2a 1 0.23 0.33 0
54 INT218296 Regulation of Acvr2b 1 0.12 0.33 0
55 INT310165 Negative_regulation of Transcription of Bmpr2 1 0.22 2.1 0
56 INT310168 Phosphorylation of Tgfbr2 1 0.41 1.5 0
57 INT218286 Regulation of Gene_expression of Acvr2b 1 0.60 0.5 0
58 INT218289 Gene_expression of Acvr2a 1 0.65 1.44 0
59 INT239992 Negative_regulation of Tgfbr2 1 0.06 0 0
60 INT218281 Binding of Acvr2b 1 0.36 0.07 0
61 INT319208 Regulation of Bmpr2 1 0.28 0.08 0
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