GO:0007186

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Name G-protein coupled receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0007186
Unique Molecular Interactions 7306
Total Molecular Interactions 10270
Total Single Events 81535
Pain Genes Associated 524

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for G-protein coupled receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for G-protein coupled receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4
2 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
3 INT68514 Pnoc Positive_regulation of Oprl1 10 0.59 3.56 9.57
4 INT65724 Binding of Pnoc and Oprl1 8 0.33 2.94 8.82
5 INT21276 Binding of Oprd1 and Penk 9 0.54 1.14 8.28
6 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
7 INT254001 Binding of Cxcr4 and Mif 1 0.52 14.17 7.18
8 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78
9 INT125407 Binding of OPRL1 and PTPRM 1 0.03 0.72 4.67
10 INT351352 Binding of Trpv1 and Lpar1 1 0.21 5.86 4.62
11 INT34444 Binding of Oprl1 and Ptprg 4 0.03 0.18 4.58
12 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
13 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
14 INT64480 Binding of OPRL1 and PNOC 2 0.33 0.23 4.38
15 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
16 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
17 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
18 INT143270 Binding of Cnr1 and Gprasp1 4 0.54 0.64 4.18
19 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 0.30 0.91 4.18
20 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16
21 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
22 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
23 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
24 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
25 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
26 INT249566 Binding of Oprd1 and Psmd1 1 0.01 0.82 3.8
27 INT136525 Binding of Prokr1 and Trpv1 1 0.39 2.9 3.76
28 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
29 INT34534 Binding of Penk and Oprl1 4 0.37 0 3.64
30 INT71069 Oprl1 Regulation of Gene_expression of Tac4 1 0.03 0.13 3.64
31 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
32 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52
33 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52
34 INT87491 CALCA Positive_regulation of Gene_expression of IL8 1 0.72 0.92 3.52
35 INT180984 IRF6 Positive_regulation of Localization of IL8 7 0.11 2.13 3.47
36 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
37 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
38 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
39 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
40 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
41 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
42 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
43 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
44 INT166134 Binding of Cxcl12 and Cxcr4 3 0.49 5.69 3.17
45 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17
46 INT1151 Binding of CCK and GAST 7 0.49 0.73 3.08
47 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08
48 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
49 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
50 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
51 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
52 INT28235 Binding of Cck and Gast 5 0.38 0.73 2.96
53 INT324927 Syt17 Positive_regulation of Bdkrb1 1 0.04 4.29 2.96
54 INT113234 Binding of Pax3 and Tacr1 3 0.12 1.54 2.93
55 INT73821 CALCA Positive_regulation of Localization of IL8 1 0.25 2.37 2.91
56 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
57 INT264929 Binding of Cnr1 and Gnaz 1 0.18 1.71 2.89
58 INT114126 Binding of APLNR and OPRL1 1 0.01 0.47 2.85
59 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82
60 INT137230 Trh Regulation of Gene_expression of Oprd1 1 0.01 1.62 2.75
61 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
62 INT226118 Ghrl Regulation of Prkag1 1 0.08 0.72 2.72
63 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
64 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
65 INT182564 Binding of Ptger2 and Trpv1 1 0.18 1.77 2.67
66 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
67 INT150457 Binding of Sort1 and Prss12 3 0.21 1.36 2.64
68 INT62450 Il2 Positive_regulation of Localization of Crh 1 0.43 0.59 2.64
69 INT7888 Oprl1 Regulation of Localization of Avp 4 0.49 0.25 2.63
70 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
71 INT152113 Binding of NTSR1 and Ngf 3 0.33 2.09 2.62
72 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
73 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59
74 INT70757 Binding of Oprl1 and Pnoc 5 0.03 0.23 2.55
75 INT104219 SCD Positive_regulation of Cnr1 1 0.00 2.67 2.54
76 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
77 INT143271 Binding of Gprasp1 and Positive_regulation of Negative_regulation of Cnr1 1 0.78 0.16 2.53
78 INT69665 Binding of Oprd1 and Pnoc 5 0.35 0.4 2.5
79 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 0.13 1.64 2.5
80 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
81 INT249567 Positive_regulation of Binding of Oprd1 and Psmd1 1 0.01 0.66 2.5
82 INT314141 Binding of Tacr3 and SFTPA1 1 0.00 3.02 2.48
83 INT287746 Anxa1 Positive_regulation of Gene_expression of Lpar1 1 0.07 1.72 2.46
84 INT317526 Binding of Hint1 and Gipc1 1 0.00 0.25 2.38
85 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
86 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
87 INT14781 Cck Regulation of Gast 3 0.38 0.28 2.3
88 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
89 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
90 INT198958 Cnr1 Positive_regulation of Kcnj9 1 0.00 0.15 2.24
91 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
92 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
93 INT1315 Pomc Positive_regulation of Localization of Gnrhr 3 0.38 0.16 2.16
94 INT5486 Oprd1 Regulation of Cck 1 0.21 0 2.16
95 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
96 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
97 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
98 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
99 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07
100 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 0.04 0.64 2.07
101 INT182200 Binding of CXCR5 and CXCL13 1 0.37 2.89 2.07
102 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
103 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
104 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
105 INT35502 Ghrh Positive_regulation of Localization of Gnrhr 7 0.57 0.18 2
106 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
107 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
108 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
109 INT122381 Positive_regulation of Pnoc Positive_regulation of Oprl1 1 0.36 1.11 1.96
110 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
111 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94
112 INT68272 Binding of Oprd1 and G2e3 1 0.00 0.11 1.93
113 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
114 INT65025 Binding of Oprm1 and Hps4 1 0.01 0 1.93
115 INT6931 Binding of Oprk1 and Pdyn 2 0.24 0.92 1.92
116 INT264928 Binding of Cnr1 and Hrh1 1 0.01 1.61 1.92
117 INT83418 Binding of OPRL1 and Ntrk1 1 0.02 0 1.91
118 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
119 INT169498 Binding of Oprm1 and Mirlet7a-1 1 0.32 0 1.9
120 INT161224 Ccl2 Positive_regulation of Ccr2 1 0.52 2.09 1.88
121 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
122 INT153582 Binding of Oprm1 and Hint1 1 0.01 0 1.87
123 INT297488 Itpr3 Regulation of Positive_regulation of Ltp 1 0.02 0.47 1.87
124 INT201940 Binding of IL8 and CXCL10 2 0.28 2.46 1.86
125 INT211747 Negative_regulation of Binding of Oprm1 and Mors1 1 0.09 0 1.86
126 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85
127 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
128 INT72468 Negative_regulation of Binding of OPRL1 and PNOC 1 0.40 0 1.83
129 INT119917 Zfp821 Positive_regulation of Positive_regulation of Oprd1 1 0.01 0 1.82
130 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
131 INT169502 Mirlet7a-1 Regulation of Oprm1 1 0.53 0 1.81
132 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
133 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
134 INT70225 oh Regulation of Oprd1 1 0.20 0.13 1.8
135 INT305741 Binding of Kcnk2 and Sort1 1 0.54 1.01 1.8
136 INT150456 Binding of Sort1 and Nts 3 0.45 0.64 1.79
137 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
138 INT168925 Binding of Oprm1 and Imraq2 1 0.04 0.13 1.78
139 INT168924 Positive_regulation of Binding of Oprm1 and Imraq2 1 0.06 0.13 1.78
140 INT211746 Binding of Oprm1 and Mors1 1 0.08 0 1.78
141 INT13979 Gast Positive_regulation of Localization of Sst 3 0.69 0.05 1.75
142 INT276863 Gpr65 Regulation of Trpv1 1 0.25 1.78 1.75
143 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
144 INT31534 Binding of Sst and Oprl1 2 0.16 0.53 1.74
145 INT129953 Oprd1 Regulation of Cspg5 1 0.17 0.15 1.74
146 INT37840 Binding of Cyp27b1 and Oprd1 1 0.01 0 1.73
147 INT182565 Ptger2 Regulation of Trpv1 1 0.25 1.34 1.73
148 INT79365 Pnoc Negative_regulation of Oprl1 2 0.41 0.16 1.72
149 INT80787 Negative_regulation of Binding of Pnoc and Oprl1 2 0.39 0.39 1.72
150 INT6407 Binding of Lama5 and Oprm1 1 0.02 0.08 1.72
151 INT264922 Binding of Cnr1 and Mors1 1 0.14 0.1 1.71
152 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
153 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
154 INT157459 Binding of CX3CR1 and CX3CL1 1 0.32 2.12 1.7
155 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
156 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
157 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69
158 INT353717 Binding of Ghrl and Vta1 1 0.15 0 1.68
159 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
160 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
161 INT18520 Adra2c Positive_regulation of Localization of Ins1 3 0.41 0.63 1.66
162 INT69666 Binding of OPRL1 and Pnoc 2 0.45 0.06 1.66
163 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
164 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
165 INT103725 Negative_regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.17 0.38 1.65
166 INT315180 Gene_expression of Mors1 Positive_regulation of Gene_expression of Oprm1 1 0.03 0.48 1.64
167 INT103726 Regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.10 0.38 1.64
168 INT199490 Penk Positive_regulation of Oprk1 1 0.03 0.87 1.64
169 INT61049 Binding of Oprd1 and Negative_regulation of Gene_expression of Odc1 1 0.21 0 1.64
170 INT138777 Binding of Galr2 and Galr1 1 0.08 1.18 1.64
171 INT182563 Ptger2 Positive_regulation of Ptger1 1 0.22 1.4 1.64
172 INT315181 Gene_expression of Mors1 Positive_regulation of Oprm1 1 0.03 0.48 1.64
173 INT90046 Oprm1 Positive_regulation of P9Ehs1 2 0.16 0.92 1.63
174 INT199501 Pdyn Positive_regulation of Oprm1 1 0.01 0.86 1.63
175 INT61674 Gpm6a Regulation of Oprd1 1 0.01 0.07 1.62
176 INT109525 Binding of DMRT1 and Oprm1 1 0.08 0 1.62
177 INT140341 Ngf Positive_regulation of Gene_expression of Oprm1 1 0.02 0.33 1.59
178 INT317558 Binding of Oprm1 and Rgs17 1 0.18 0 1.59
179 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
180 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
181 INT66408 Pomc Positive_regulation of Regulation of HRH1 1 0.01 0 1.58
182 INT40827 Sstr1 Negative_regulation of Localization of Gh1 1 0.13 0 1.58
183 INT41652 Binding of Pomc and Oprl1 3 0.16 0 1.57
184 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
185 INT148935 Ramp1 Regulation of Calca 1 0.27 0.69 1.56
186 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
187 INT127253 Binding of Npb and Npbwr1 2 0.29 0.61 1.55
188 INT6768 Oprl1 Regulation of Localization of Prl 2 0.12 0 1.55
189 INT148821 Binding of Oprm1 and Grin1 1 0.05 0.24 1.55
190 INT264950 Binding of FPR1 and BOC 1 0.11 0.67 1.55
191 INT148820 Binding of Oprm1 and Naa15 1 0.02 0.24 1.55
192 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
193 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54
194 INT8734 Pebp1 Positive_regulation of Oprd1 1 0.01 0 1.54
195 INT41101 Mdk Negative_regulation of SST 1 0.02 0 1.53
196 INT111828 UPB1 Positive_regulation of Oprm1 1 0.00 0.85 1.53
197 INT192081 Igkv11-125 Positive_regulation of Cnr1 1 0.10 0.23 1.51
198 INT260897 CRH Positive_regulation of Localization of IL8 1 0.24 0.09 1.51
199 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5
200 INT72666 Binding of ODT and Oprm1 1 0.03 0.53 1.5

Single Events

The table below shows the top 100 pain related interactions that have been reported for G-protein coupled receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in G-protein coupled receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
2 INT5660 Binding of Oprd1 477 0.48 71.86 342.06
3 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32
4 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
5 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41
6 INT10832 Gene_expression of IL8 1050 0.78 698.72 270
7 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9
8 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
9 INT1212 Binding of Oprl1 312 0.48 28.6 225.15
10 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61
11 INT767 Localization of Gnrhr 565 0.80 106.68 214.57
12 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
13 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
14 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93
15 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11
16 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02
17 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93
18 INT6042 Binding of Oprm1 248 0.48 31.77 154.34
19 INT812 Localization of INS 1026 0.81 515.6 145.31
20 INT1414 Regulation of Oprl1 169 0.62 32.05 139.99
21 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74
22 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93
23 INT12339 Localization of IL8 437 0.81 251.87 117.39
24 INT90 Localization of Gast 400 0.81 137.67 113
25 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34
26 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
27 INT12569 Localization of Oprd1 94 0.81 23.81 104.56
28 INT114 Binding of Oprl1 139 0.48 23 103.35
29 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62
30 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
31 INT397 Localization of SST 232 0.81 58.05 101.19
32 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4
33 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97
34 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49
35 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7
36 INT18032 Positive_regulation of Oprk1 108 0.70 30.78 89.7
37 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
38 INT1309 Positive_regulation of Localization of Gnrhr 152 0.69 24.25 81.56
39 INT86521 Gene_expression of Lpar1 167 0.78 154.61 80.35
40 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64
41 INT1335 Negative_regulation of Oprl1 123 0.59 18.02 77.13
42 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68
43 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34
44 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33
45 INT8347 Gene_expression of SST 181 0.78 104.59 65.45
46 INT11807 Gene_expression of Il2 266 0.78 112 64.97
47 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
48 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1
49 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85
50 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
51 INT770 Regulation of Localization of Gnrhr 127 0.61 17.91 58.23
52 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
53 INT20266 Positive_regulation of Bdkrb1 60 0.69 63.64 56.59
54 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66
55 INT251 Regulation of INS 398 0.62 232.47 55.04
56 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
57 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54
58 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78
59 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87
60 INT929 Positive_regulation of Oprl1 64 0.70 14.67 52.84
61 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12
62 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75
63 INT5118 Regulation of SST 97 0.62 34.35 51.74
64 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
65 INT12345 Gene_expression of Il2 142 0.78 59.17 51.21
66 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
67 INT76620 Gene_expression of Cnr2 93 0.78 34.7 50.14
68 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
69 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
70 INT32718 Gene_expression of OPRD1 82 0.76 9.43 48.38
71 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01
72 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
73 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
74 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
75 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22
76 INT63383 Binding of Cnr1 77 0.48 22.28 44.61
77 INT7828 Positive_regulation of Oprd1 55 0.69 14.11 42.86
78 INT1319 Gene_expression of Oprl1 65 0.78 9.34 42.41
79 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07
80 INT30 Gene_expression of Gast 158 0.78 99 41.45
81 INT49643 Gene_expression of Bdkrb1 39 0.78 46.49 40.21
82 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84
83 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
84 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
85 INT1596 Negative_regulation of Oprl1 61 0.57 13.5 38.41
86 INT65125 Gene_expression of Tacr1 81 0.77 23.9 38.35
87 INT43507 Gene_expression of Gabbr1 79 0.78 28.53 38.22
88 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
89 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
90 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2
91 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01
92 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
93 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58
94 INT14137 Localization of Oprm1 56 0.81 2.88 36.09
95 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
96 INT13501 Binding of Drd2 65 0.48 23.76 35.6
97 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54
98 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22
99 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
100 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93
101 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
102 INT692 Negative_regulation of SST 72 0.59 28.68 34.52
103 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52
104 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29
105 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
106 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15
107 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72
108 INT95789 Positive_regulation of Grm5 42 0.55 20.1 33.72
109 INT33768 Positive_regulation of Cysltr1 87 0.46 54.66 33.52
110 INT50308 Binding of Cnr1 61 0.48 14.41 33.52
111 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52
112 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03
113 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95
114 INT65698 Localization of CCL2 118 0.81 77.54 32.69
115 INT691 Binding of SST 67 0.48 24.66 32.67
116 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
117 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72
118 INT51685 Gene_expression of LTB4R 87 0.58 68.69 31.72
119 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
120 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
121 INT12397 Gene_expression of Oprd1 53 0.78 9.1 31.31
122 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11
123 INT2278 Regulation of Localization of Gast 81 0.62 16.93 30.64
124 INT29477 Transcription of Oprl1 52 0.72 5.05 30.52
125 INT8691 Localization of Insr 85 0.80 9.27 30.32
126 INT1158 Regulation of Agt 106 0.61 29.4 30.29
127 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21
128 INT28 Regulation of Gast 106 0.62 26.37 29.85
129 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66
130 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48
131 INT91 Positive_regulation of Localization of Gast 96 0.70 23.22 29.36
132 INT5300 Regulation of Insr 54 0.60 11.33 29.26
133 INT15000 Transcription of Oprd1 32 0.72 5.7 29.22
134 INT6765 Localization of Oprl1 49 0.81 5.11 28.87
135 INT10506 Gene_expression of PTAFR 86 0.76 37.57 28.58
136 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
137 INT182223 Gene_expression of CXCR5 57 0.76 51.49 28.4
138 INT88046 Gene_expression of Ccr2 38 0.76 33.76 28.07
139 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
140 INT233457 Gene_expression of Gpr65 56 0.68 26.57 27.94
141 INT5097 Localization of Sstr1 30 0.64 0.38 27.92
142 INT5771 Binding of Oprd1 37 0.48 2.6 27.54
143 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46
144 INT111359 Localization of Cnr1 55 0.81 11.25 27.41
145 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
146 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
147 INT75418 Negative_regulation of Cnr1 41 0.59 14.65 27.28
148 INT116861 Gene_expression of Apoe 182 0.78 100.41 27.26
149 INT1765 Positive_regulation of Gene_expression of PTGER2 140 0.51 68.68 27
150 INT97 Negative_regulation of Adrb1 102 0.59 32.44 26.9
151 INT28834 Positive_regulation of Bdkrb1 38 0.69 30.48 26.89
152 INT72677 Regulation of Gene_expression of Oprm1 45 0.62 13.95 26.75
153 INT29107 Regulation of Oprk1 31 0.45 6.16 26.61
154 INT76621 Positive_regulation of Cnr2 32 0.69 17.77 26.57
155 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48
156 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41
157 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26
158 INT6934 Binding of OPRD1 51 0.48 7.72 25.73
159 INT47075 Positive_regulation of Ptger2 142 0.70 78.55 25.47
160 INT17625 Localization of GCG 210 0.80 55.69 24.97
161 INT29 Negative_regulation of Gast 74 0.59 24.85 24.96
162 INT6179 Binding of Oprk1 37 0.48 9.24 24.83
163 INT74377 Regulation of Cnr1 38 0.59 16.93 24.77
164 INT12484 Binding of Drd2 45 0.48 15.17 24.72
165 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71
166 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
167 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52
168 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43
169 INT141612 Gene_expression of Ccr1 92 0.77 72.09 24.14
170 INT10835 Regulation of IL8 79 0.49 53.04 24.14
171 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
172 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
173 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42
174 INT12475 Gene_expression of OPRL1 35 0.77 3.63 23.11
175 INT30386 Negative_regulation of OPRD1 33 0.52 4.34 23.06
176 INT9282 Gene_expression of HTR1B 48 0.75 12.15 22.94
177 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79
178 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78
179 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
180 INT57253 Negative_regulation of Binding of Oprm1 24 0.43 5.27 22.67
181 INT7383 Localization of VIP 53 0.81 17.7 22.65
182 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
183 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
184 INT96741 Gene_expression of Cxcr4 62 0.78 32.3 22.14
185 INT9988 Regulation of Hrh1 22 0.46 12.87 22.13
186 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
187 INT693 Negative_regulation of Localization of SST 46 0.59 8.57 21.75
188 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63
189 INT1644 Regulation of FSHR 77 0.55 15.62 21.49
190 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38
191 INT2978 Gene_expression of Tbxa2r 76 0.77 28.4 21.27
192 INT31393 Positive_regulation of Localization of Oprd1 10 0.66 7.32 21.23
193 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87
194 INT52106 Negative_regulation of Localization of IL8 57 0.52 22.81 20.8
195 INT50778 Gene_expression of Adrbk1 24 0.77 11.61 20.73
196 INT166115 Positive_regulation of Gene_expression of Lpar1 42 0.61 31 20.71
197 INT90849 Gene_expression of F2rl1 55 0.78 31.31 20.65
198 INT1334 Negative_regulation of Binding of Oprl1 29 0.59 3.03 20.62
199 INT54708 Gene_expression of Adrbk1 22 0.75 1.06 20.62
200 INT112930 Negative_regulation of Adrbk1 17 0.58 15.04 20.41
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