GO:0007187

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Name G-protein signaling, coupled to cyclic nucleotide second messenger
Categary Process
Go Slim No
Go Link GO:0007187
Unique Molecular Interactions 616
Total Molecular Interactions 924
Total Single Events 7044
Pain Genes Associated 38

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for G-protein signaling, coupled to cyclic nucleotide second messenger. They are ordered first by their pain relevance and then by number of times they were reported for G-protein signaling, coupled to cyclic nucleotide second messenger. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
3 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
4 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
5 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
6 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
7 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97
8 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
9 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
10 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71
11 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
12 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
13 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17
14 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
15 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
16 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
17 INT104218 SCD Positive_regulation of CNR2 1 0.01 2.67 2.54
18 INT143272 Binding of CNR1 and Gprasp1 1 0.01 0.17 2.42
19 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
20 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
21 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
22 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
23 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
24 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
25 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
26 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
27 INT110525 Binding of MC1R and OCA2 1 0.41 1.08 1.97
28 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
29 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
30 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
31 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
32 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
33 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
34 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
35 INT102447 Binding of CALCA and CALCRL 2 0.26 0.33 1.67
36 INT134742 Binding of OPRM1 and SV2A 1 0.33 0.18 1.64
37 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
38 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
39 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
40 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
41 INT145072 ASIP Negative_regulation of MC1R 1 0.29 0 1.52
42 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47
43 INT141676 OPRM1 Positive_regulation of Ltp 1 0.04 0 1.46
44 INT141675 OPRM1 Positive_regulation of Negative_regulation of Ltp 1 0.04 0 1.46
45 INT161858 OPRM1 Positive_regulation of GRIN1 1 0.50 0.12 1.45
46 INT95325 HTR1B Negative_regulation of Calca 1 0.47 0.69 1.43
47 INT128915 PENK Regulation of Gene_expression of OPRM1 1 0.22 0.07 1.43
48 INT76770 Binding of HTR1E and Gs 1 0.00 0.87 1.42
49 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41
50 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
51 INT51203 Binding of OPRK1 and OPRM1 2 0.29 0.3 1.36
52 INT160590 CSF2 Positive_regulation of Gene_expression of OPRM1 1 0.16 0.54 1.35
53 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
54 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
55 INT160587 IFNG Positive_regulation of Gene_expression of OPRM1 1 0.18 0.54 1.35
56 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
57 INT160589 IL4 Positive_regulation of Gene_expression of OPRM1 1 0.13 0.54 1.35
58 INT261463 Binding of Drd1a and Sftpd 1 0.12 0.13 1.35
59 INT52568 HTR1D Regulation of Localization of Gh 2 0.20 0.16 1.34
60 INT51200 Binding of OPRM1 and PENK 2 0.17 0.23 1.31
61 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
62 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
63 INT71109 Binding of INSRR and MC1R 1 0.01 0 1.27
64 INT110542 SIGMAR1 Regulation of OPRM1 1 0.04 0.33 1.25
65 INT110543 SIGMAR1 Regulation of Gene_expression of OPRM1 1 0.04 0.33 1.25
66 INT167278 Binding of OPRM1 and REST 1 0.08 0.94 1.24
67 INT136249 Drd1a Positive_regulation of Phosphorylation of Tff3 1 0.01 0.18 1.23
68 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
69 INT200455 OPRK1 Positive_regulation of Gene_expression of CCL2 1 0.19 0.07 1.21
70 INT140238 HELQ Regulation of MC1R 1 0.01 0.5 1.2
71 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
72 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
73 INT49956 OPRM1 Positive_regulation of SGCG 1 0.53 0.3 1.18
74 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
75 INT137144 ITIH4 Regulation of OPRM1 1 0.20 1.13 1.16
76 INT212815 WAS Positive_regulation of CNR1 1 0.01 0.62 1.16
77 INT125696 Binding of OPRM1 and SNRNP70 1 0.06 0.99 1.15
78 INT225104 CNR1 Positive_regulation of Gene_expression of RETNLB 1 0.01 1.41 1.14
79 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
80 INT123454 CNR1 Regulation of Fos 1 0.00 0.06 1.12
81 INT221183 Binding of OPRM1 and Mors1 1 0.00 0 1.12
82 INT260810 Binding of CXCL10 and CCL2 1 0.10 1.37 1.12
83 INT123455 CNR1 Regulation of Positive_regulation of Fos 1 0.00 0.06 1.12
84 INT113540 Binding of OPRM1 and Tac1 1 0.04 0.1 1.1
85 INT127133 Positive_regulation of OPRM1 Positive_regulation of Protein_catabolism of SUCLG2 1 0.20 0.2 1.1
86 INT74185 Cck Negative_regulation of Drd1a 1 0.30 0.1 1.1
87 INT90145 Binding of OPRL1 and OPRM1 2 0.27 0.31 1.08
88 INT50889 Binding of HTR1A and HTR1D 2 0.40 0.31 1.05
89 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 0.40 0 1.05
90 INT97011 Binding of CALM3 and OPRM1 1 0.35 0 1.05
91 INT133075 TFAM Positive_regulation of Transcription of OPRM1 1 0.03 0 1.04
92 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 0.35 0 1.04
93 INT51204 Positive_regulation of Binding of OPRK1 and OPRM1 1 0.38 0.3 1.03
94 INT127997 Binding of MC1R and RHCE 2 0.28 0.41 1.02
95 INT7025 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.08 1.01
96 INT60208 Binding of Htr1a and Htr2c 2 0.52 0.25 1
97 INT95791 Binding of SSTR1 and GRHL3 1 0.38 0.57 0.99
98 INT1415 Binding of OPRM1 and POMC 3 0.16 0.3 0.98
99 INT51201 Negative_regulation of Binding of OPRM1 and PENK 1 0.20 0.23 0.98
100 INT239539 Binding of CXCR2 and CALCRL 1 0.00 0.38 0.98
101 INT157522 GRM5 Regulation of Gene_expression of OPRM1 1 0.28 0 0.97
102 INT40287 OPRM1 Positive_regulation of Negative_regulation of Prl 1 0.00 0.93 0.96
103 INT87854 Binding of Drd1a and Positive_regulation of Localization of Abat 1 0.08 0 0.96
104 INT133076 STAT6 Positive_regulation of OPRM1 1 0.38 0 0.95
105 INT135585 CSF2 Regulation of CCL2 1 0.13 2.51 0.95
106 INT74184 Cck Regulation of Localization of Drd1a 1 0.32 0.06 0.95
107 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
108 INT152388 Binding of NFKB1 and OPRM1 1 0.04 0.14 0.94
109 INT152390 Negative_regulation of Binding of JUN and OPRM1 1 0.13 0.14 0.94
110 INT152387 Binding of JUN and OPRM1 1 0.15 0.14 0.94
111 INT232426 HRH2 Regulation of Localization of PRL 1 0.15 0.38 0.94
112 INT152389 Negative_regulation of Binding of NFKB1 and OPRM1 1 0.05 0.14 0.94
113 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
114 INT128860 NR1H4 Negative_regulation of Gene_expression of OPRM1 1 0.15 0.31 0.92
115 INT89314 Binding of CRYGS and OPRM1 1 0.07 0.08 0.91
116 INT136172 NPY Negative_regulation of Positive_regulation of Drd1a 1 0.21 0 0.91
117 INT7292 Binding of Drd1a and Penk 1 0.14 0 0.9
118 INT113946 Binding of FLNA and OPRM1 1 0.10 0.37 0.9
119 INT52760 Oprd1 Regulation of Drd1a 1 0.02 0 0.9
120 INT128859 Positive_regulation of RXRA Regulation of Gene_expression of OPRM1 1 0.05 0.26 0.9
121 INT141965 Binding of ADM and CALCRL 5 0.33 3.6 0.89
122 INT52762 Dll1 Regulation of Drd1a 1 0.10 0 0.89
123 INT239533 Binding of MTNR1A and NCOR2 1 0.01 0.53 0.87
124 INT337899 Positive_regulation of MC3R Positive_regulation of Gene_expression of Bdnf 1 0.31 0 0.87
125 INT52390 OPRD1 Regulation of ADCY1 1 0.09 0.13 0.86
126 INT29279 Binding of Drd1a and Htr1a 1 0.35 0.2 0.84
127 INT344101 Positive_regulation of Drd1a Positive_regulation of Localization of Abat 1 0.01 0 0.84
128 INT287494 CRP Positive_regulation of Gene_expression of CCL2 2 0.30 2.33 0.83
129 INT149561 Tgfb1 Positive_regulation of Gene_expression of CCL2 1 0.00 0 0.83
130 INT149563 Tgfb1 Positive_regulation of CCL2 1 0.00 0 0.83
131 INT97012 Binding of CALM1 and OPRM1 1 0.18 0 0.82
132 INT162071 Gene_expression of MC1R Negative_regulation of Gene_expression of TNF 1 0.41 0.34 0.82
133 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
134 INT77393 Binding of ARRB1 and OPRM1 1 0.15 0 0.82
135 INT89529 OPRM1 Regulation of CALM1 1 0.27 0 0.81
136 INT87489 CALCA Positive_regulation of Gene_expression of CCL2 1 0.43 0.14 0.81
137 INT90143 Negative_regulation of Binding of OPRL1 and OPRM1 1 0.31 0.07 0.8
138 INT130286 MC1R Positive_regulation of Localization of IL10 1 0.24 0.07 0.79
139 INT151807 Binding of NFATC1 and OPRM1 1 0.19 0 0.79
140 INT141963 Binding of CALCRL and RAMP1 2 0.43 0.81 0.78
141 INT149495 PNOC Negative_regulation of CCL2 1 0.11 0.16 0.77
142 INT133074 CNR2 Positive_regulation of Transcription of OPRM1 1 0.11 0 0.77
143 INT124385 GRK6 Negative_regulation of MC1R 1 0.42 0.42 0.77
144 INT124384 ADRBK1 Negative_regulation of MC1R 1 0.40 0.42 0.77
145 INT353721 Negative_regulation of Binding of Drd1a and Ghsr 1 0.16 0 0.76
146 INT151808 NFATC1 Positive_regulation of Positive_regulation of OPRM1 1 0.20 0 0.76
147 INT353720 Binding of Drd1a and Ghsr 1 0.18 0 0.76
148 INT113222 POMC Regulation of Gene_expression of MC1R 1 0.06 0 0.76
149 INT21260 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.05 0 0.76
150 INT127585 Binding of CNR2 and Ctbp1 1 0.00 0.6 0.76
151 INT96795 ITIH4 Positive_regulation of Gene_expression of OPRM1 1 0.49 0.17 0.76
152 INT128861 LBR Positive_regulation of Positive_regulation of OPRM1 1 0.19 0.36 0.75
153 INT292598 CNR1 Regulation of ABAT 1 0.08 0.32 0.75
154 INT113224 Binding of ASIP and MC1R 1 0.00 0 0.75
155 INT81011 CNR1 Positive_regulation of Gene_expression of PENK 1 0.54 0 0.75
156 INT292599 CNR1 Regulation of Localization of ABAT 1 0.08 0.32 0.75
157 INT127584 Binding of CNR1 and Ctbp1 1 0.00 0.6 0.75
158 INT144455 Binding of CNR1 and GPM6A 1 0.02 0 0.74
159 INT151810 JUND Positive_regulation of Positive_regulation of OPRM1 1 0.26 0 0.74
160 INT327707 Binding of Comt and Drd1a 1 0.18 0.27 0.74
161 INT131468 Positive_regulation of POMC Positive_regulation of MC1R 1 0.00 0 0.74
162 INT151809 JUN Positive_regulation of Positive_regulation of OPRM1 1 0.32 0 0.74
163 INT133070 Positive_regulation of CNR2 Positive_regulation of Transcription of OPRM1 1 0.11 0 0.74
164 INT258644 Binding of CCL2 and CCL5 1 0.36 1.6 0.74
165 INT144453 Binding of GPM6A and SSTR2 1 0.02 0 0.74
166 INT258643 Positive_regulation of Binding of CCL2 and CCL5 1 0.49 1.61 0.74
167 INT151806 TRAF3IP2 Positive_regulation of Positive_regulation of OPRM1 1 0.06 0 0.74
168 INT113225 POMC Regulation of Transcription of MC1R 1 0.03 0 0.74
169 INT104974 MITF Positive_regulation of MC1R 1 0.52 0.16 0.74
170 INT133940 Binding of OPRD1 and ARFGEF1 1 0.02 0 0.73
171 INT133934 Binding of OPRD1 and PDYN 1 0.02 0 0.73
172 INT157063 SLC12A1 Negative_regulation of CALCRL 1 0.00 0.34 0.73
173 INT157541 Binding of YY1 and Regulation of Gene_expression of OPRM1 1 0.31 1.21 0.72
174 INT76769 Negative_regulation of Binding of HTR1E and Gs 1 0.00 0.44 0.72
175 INT137139 ITIH4 Positive_regulation of OPRM1 1 0.37 0.67 0.72
176 INT157539 Binding of SP1 and Regulation of Gene_expression of OPRM1 1 0.36 1.2 0.72
177 INT117012 Binding of OPRD1 and TCN2 1 0.02 0 0.72
178 INT162162 ARF6 Regulation of OPRM1 1 0.19 0 0.71
179 INT239538 Binding of CXCR4 and CALCRL 1 0.00 0.35 0.71
180 INT155139 Binding of MC1R and PTGES 3 0.09 0 0.7
181 INT82759 Binding of IGHG3 and OPRM1 2 0.06 0 0.7
182 INT120017 CCL2 Positive_regulation of CCL3 1 0.01 0.99 0.7
183 INT120020 VEGFA Positive_regulation of CCL2 1 0.00 1 0.7
184 INT120035 CCL2 Positive_regulation of Prap1 1 0.00 0.99 0.7
185 INT107741 Binding of OPRM1 and Pld2 1 0.01 0 0.69
186 INT99938 Drd1a Regulation of Transcription of Qrfp 1 0.03 0 0.69
187 INT26230 Binding of GSR and HTR1D 1 0.12 0.15 0.69
188 INT81787 Binding of AGRP and MC1R 1 0.53 0 0.69
189 INT134652 Binding of MC1R and SUGT1 1 0.02 0.84 0.68
190 INT140235 ADRBK1 Positive_regulation of Binding of MC1R 1 0.46 0.31 0.68
191 INT120381 Binding of CNR1 and Fos 1 0.00 0.52 0.68
192 INT222181 TFAM Positive_regulation of XCR1 1 0.00 1.89 0.68
193 INT140236 GRK6 Positive_regulation of Binding of MC1R 1 0.52 0.31 0.68
194 INT71988 Drd1a Regulation of Npr1 1 0.10 0 0.68
195 INT99939 Drd1a Regulation of Qrfp 1 0.03 0 0.68
196 INT130717 Binding of OPRM1 and Positive_regulation of Localization of CCL2 1 0.00 0.72 0.68
197 INT140234 Gene_expression of GRK6 Positive_regulation of Gene_expression of MC1R 1 0.52 0.31 0.68
198 INT140237 Gene_expression of ADRBK1 Positive_regulation of Gene_expression of MC1R 1 0.46 0.31 0.68
199 INT86638 POMC Negative_regulation of Gene_expression of OPRM1 1 0.34 0.33 0.68
200 INT52570 HTR1D Negative_regulation of Localization of SST 1 0.46 0.07 0.67

Single Events

The table below shows the top 100 pain related interactions that have been reported for G-protein signaling, coupled to cyclic nucleotide second messenger. They are ordered first by their pain relevance and then by number of times they were reported in G-protein signaling, coupled to cyclic nucleotide second messenger. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
2 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02
3 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
4 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
5 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55
6 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
7 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
8 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84
9 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85
10 INT21737 Binding of MC1R 129 0.48 45.45 56.54
11 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
12 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
13 INT62630 Positive_regulation of CNR1 86 0.70 40.34 51.51
14 INT32718 Gene_expression of OPRD1 82 0.76 9.43 48.38
15 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22
16 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
17 INT16194 Binding of CNR1 82 0.48 20.75 39.59
18 INT12608 Regulation of CNR1 62 0.60 24.36 36.02
19 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
20 INT65698 Localization of CCL2 118 0.81 77.54 32.69
21 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
22 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
23 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52
24 INT6594 Gene_expression of HTR1D 60 0.75 10.15 27.13
25 INT6934 Binding of OPRD1 51 0.48 7.72 25.73
26 INT81496 Gene_expression of CNR2 68 0.75 30.04 24.92
27 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43
28 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42
29 INT30386 Negative_regulation of OPRD1 33 0.52 4.34 23.06
30 INT15458 Gene_expression of NPY 50 0.76 22.67 23.03
31 INT9282 Gene_expression of HTR1B 48 0.75 12.15 22.94
32 INT6270 Binding of HTR1D 55 0.47 9.54 22.86
33 INT10442 Negative_regulation of CNR1 47 0.59 20.88 20.2
34 INT9782 Binding of HTR1B 43 0.47 12.08 19.83
35 INT11243 Localization of NPY 33 0.78 11.18 19.24
36 INT7680 Regulation of Drd1a 27 0.45 4.52 18.86
37 INT66857 Regulation of CCL2 39 0.53 28.55 18.35
38 INT55880 Negative_regulation of Gene_expression of CCL2 49 0.59 22.37 18.09
39 INT55878 Regulation of Gene_expression of CCL2 34 0.62 15.71 17.97
40 INT8332 Positive_regulation of OPRD1 30 0.61 3.88 17.65
41 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51
42 INT9358 Positive_regulation of HTR1B 26 0.67 11 17.51
43 INT22068 Binding of CALCRL 53 0.41 6.14 17.32
44 INT7020 Negative_regulation of Drd1a 25 0.57 1.84 17.1
45 INT84712 Regulation of MC1R 36 0.62 9.34 16.91
46 INT32753 Positive_regulation of Positive_regulation of OPRM1 19 0.62 3.3 16.73
47 INT62629 Localization of CNR1 35 0.76 11.86 16.3
48 INT4769 Regulation of OPRD1 20 0.44 2.05 15.97
49 INT5859 Positive_regulation of Positive_regulation of Drd1a 20 0.55 2.05 15.61
50 INT42810 Gene_expression of CALCRL 53 0.77 10.87 15.42
51 INT81495 Positive_regulation of CNR2 28 0.67 14.62 14.27
52 INT76863 Negative_regulation of Gene_expression of OPRM1 21 0.57 6.56 13.69
53 INT80883 Positive_regulation of Phosphorylation of OPRM1 13 0.69 1.03 13.65
54 INT96850 Negative_regulation of CCL2 42 0.59 24.89 12.55
55 INT63104 Negative_regulation of CALCRL 29 0.37 13.62 12.42
56 INT83601 Binding of CNR2 30 0.47 7.79 12.37
57 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09
58 INT7682 Binding of Drd1a 22 0.48 1.8 11.83
59 INT18001 Positive_regulation of Htr2c 21 0.67 7.63 11.39
60 INT15238 Positive_regulation of NPY 24 0.67 11.86 11.26
61 INT5464 Regulation of CALCRL 24 0.16 4.2 11.19
62 INT83450 Positive_regulation of Localization of CCL2 28 0.70 22.14 9.83
63 INT5465 Positive_regulation of CALCRL 25 0.49 7.24 9.8
64 INT64451 Negative_regulation of MC1R 21 0.59 4.94 9.22
65 INT33209 Positive_regulation of Binding of OPRM1 8 0.68 0.63 8.95
66 INT56775 Binding of Htr2c 16 0.47 3.77 8.74
67 INT16735 Localization of Drd1a 11 0.61 0.35 8.42
68 INT7588 Regulation of NPY 13 0.44 6.97 7.97
69 INT10444 Positive_regulation of Gene_expression of CNR1 18 0.69 8.69 7.84
70 INT9032 Regulation of Htr2c 11 0.60 2.77 7.81
71 INT31060 Negative_regulation of Binding of OPRM1 12 0.37 2.65 7.75
72 INT101721 Positive_regulation of Transcription of OPRM1 8 0.48 1.22 7.74
73 INT298 Negative_regulation of ADRB3 23 0.59 6.82 7.56
74 INT6307 Positive_regulation of HTR1D 17 0.67 3.11 7.51
75 INT121815 Regulation of Positive_regulation of OPRM1 7 0.62 0.75 7.36
76 INT91609 Regulation of Gene_expression of MC1R 11 0.62 2.75 7.34
77 INT96969 Positive_regulation of Positive_regulation of CNR1 9 0.48 1.27 7.19
78 INT25772 Regulation of HTR1B 15 0.60 3.8 7.17
79 INT22369 Negative_regulation of Drd1a 15 0.47 6.13 6.87
80 INT93144 Gene_expression of CCR1 18 0.75 14.69 6.84
81 INT81493 Transcription of CCL2 20 0.65 13.63 6.78
82 INT34767 Gene_expression of PTGIR 36 0.42 14.79 6.69
83 INT120895 Binding of CCL2 22 0.37 15.86 6.55
84 INT10445 Transcription of CNR1 16 0.68 6.75 6.4
85 INT42832 Negative_regulation of Positive_regulation of OPRM1 6 0.36 0.96 6.35
86 INT54747 Localization of OPRD1 7 0.73 0.69 6.27
87 INT97600 Regulation of Transcription of OPRM1 8 0.52 1.14 6.21
88 INT233812 Gene_expression of PTH1R 32 0.77 18.15 6.15
89 INT21552 Regulation of Drd1a 10 0.57 3.7 6.05
90 INT27118 Regulation of Binding of OPRM1 10 0.62 1.18 5.97
91 INT22187 Localization of HTR1D 6 0.78 5.26 5.97
92 INT49477 Gene_expression of Htr2c 12 0.75 3.26 5.73
93 INT110545 Regulation of Regulation of OPRM1 7 0.42 1.68 5.67
94 INT69700 Transcription of MC1R 15 0.71 4.32 5.62
95 INT18366 Negative_regulation of Positive_regulation of Drd1a 6 0.42 0.49 5.54
96 INT32979 Positive_regulation of Localization of OPRM1 5 0.50 0 5.54
97 INT62835 Binding of HTR1F 12 0.47 2 5.43
98 INT60821 Negative_regulation of HTR1D 15 0.57 0.69 5.27
99 INT62916 Gene_expression of HTR1F 12 0.75 3.25 5.24
100 INT34770 Negative_regulation of PTGIR 16 0.41 8.52 5.21
101 INT66305 Negative_regulation of HTR1B 9 0.57 1.7 5.15
102 INT101925 Binding of Drd1a 9 0.43 1.82 4.97
103 INT42833 Positive_regulation of Negative_regulation of OPRM1 6 0.48 0.12 4.95
104 INT58622 Gene_expression of HTR7 13 0.75 2.86 4.7
105 INT60813 Regulation of HTR1D 10 0.60 3.4 4.67
106 INT96851 Negative_regulation of Localization of CCL2 14 0.53 5.98 4.57
107 INT48567 Transcription of Drd1a 7 0.51 2.44 4.54
108 INT14714 Negative_regulation of NPY 10 0.58 4.41 4.52
109 INT113078 Phosphorylation of Drd1a 4 0.30 0.77 4.45
110 INT13333 Regulation of Gene_expression of Drd1a 8 0.36 3.37 4.28
111 INT52402 Negative_regulation of Htr2c 7 0.42 1.46 4.21
112 INT4104 Gene_expression of ADRB3 19 0.78 2.68 4.12
113 INT38249 Positive_regulation of VIPR1 9 0.40 2.58 3.96
114 INT140542 Gene_expression of SSTR2 18 0.65 13.58 3.94
115 INT65700 Localization of CCR1 7 0.51 4 3.91
116 INT73796 Localization of HTR7 8 0.78 2.39 3.87
117 INT109 Binding of ADRB3 17 0.47 3.02 3.84
118 INT24366 Positive_regulation of Localization of NPY 4 0.50 4.01 3.79
119 INT116220 Localization of HTR1B 5 0.78 1.86 3.75
120 INT63625 Gene_expression of HTR4 3 0.65 3.37 3.73
121 INT80882 Negative_regulation of Phosphorylation of OPRM1 4 0.45 0.21 3.68
122 INT84005 Negative_regulation of Positive_regulation of CNR1 7 0.41 3.55 3.66
123 INT80923 Negative_regulation of Binding of CNR1 7 0.19 0.78 3.61
124 INT63621 Transcription of Htr2c 6 0.52 0.62 3.49
125 INT52392 Positive_regulation of Gene_expression of OPRD1 6 0.64 0.23 3.43
126 INT236824 Negative_regulation of Gene_expression of PTH1R 10 0.58 9.3 3.42
127 INT54840 Localization of HTR4 6 0.73 2.67 3.42
128 INT59706 Transcription of HTR1B 5 0.69 0.4 3.4
129 INT120874 Regulation of CNR2 7 0.44 2.47 3.39
130 INT13347 Regulation of Negative_regulation of OPRM1 5 0.45 0.64 3.38
131 INT62901 Positive_regulation of Gene_expression of Drd1a 2 0.57 0.66 3.35
132 INT74962 Phosphorylation of OPRD1 5 0.82 0.18 3.26
133 INT102451 Localization of CALCRL 9 0.69 0 3.25
134 INT24296 Binding of NPY 6 0.48 2.03 3.23
135 INT13335 Negative_regulation of Gene_expression of Drd1a 6 0.34 0.8 3.16
136 INT31912 Regulation of Binding of OPRD1 3 0.25 0.93 3.11
137 INT10443 Regulation of Gene_expression of CNR1 10 0.50 3.96 3.06
138 INT62652 Binding of HTR7 9 0.47 2.79 3.06
139 INT18365 Positive_regulation of Regulation of Drd1a 4 0.50 1.74 3.04
140 INT53402 Gene_expression of Htr7 7 0.75 1.13 3.02
141 INT57145 Transcription of OPRD1 6 0.61 0.34 2.99
142 INT81494 Positive_regulation of Gene_expression of CNR2 7 0.62 1.54 2.95
143 INT113077 Positive_regulation of Phosphorylation of Drd1a 1 0.11 0.15 2.87
144 INT61136 Localization of MC1R 8 0.75 2.8 2.85
145 INT48688 Positive_regulation of HTR4 12 0.67 1.94 2.81
146 INT65000 Positive_regulation of Positive_regulation of Htr2c 4 0.67 0.69 2.8
147 INT70474 Transcription of HTR1F 7 0.67 1.27 2.79
148 INT111422 Positive_regulation of Regulation of CNR1 3 0.03 0.56 2.76
149 INT24880 Positive_regulation of HRH2 7 0.69 1.34 2.74
150 INT70480 Localization of HTR1F 2 0.78 1.6 2.72
151 INT755 Regulation of HRH2 7 0.45 2.87 2.68
152 INT63628 Positive_regulation of Htr7 3 0.67 1.07 2.68
153 INT13904 Transcription of NPY 6 0.67 1.57 2.66
154 INT162074 Negative_regulation of Transcription of MC1R 1 0.42 1.05 2.65
155 INT64248 Positive_regulation of Positive_regulation of Drd1a 6 0.45 1.97 2.62
156 INT59705 Transcription of HTR1D 6 0.67 0.26 2.59
157 INT89992 Positive_regulation of Gene_expression of Drd1a 5 0.39 2.11 2.54
158 INT97807 Negative_regulation of Regulation of CNR1 2 0.09 0.89 2.51
159 INT172592 Positive_regulation of PTH1R 9 0.28 6.25 2.5
160 INT13733 Localization of SSTR1 8 0.65 3.11 2.49
161 INT64062 Negative_regulation of Regulation of OPRM1 2 0.41 0.3 2.48
162 INT9357 Positive_regulation of Positive_regulation of HTR1B 5 0.49 0.88 2.47
163 INT122656 Gene_expression of MTNR1A 21 0.75 6.37 2.46
164 INT168658 Regulation of Gene_expression of HTR1B 2 0.44 2.11 2.44
165 INT59710 Positive_regulation of Negative_regulation of OPRD1 1 0.36 0.21 2.41
166 INT83701 Localization of Htr7 5 0.78 0.67 2.39
167 INT80926 Regulation of HTR4 4 0.60 1.85 2.36
168 INT86462 Transcription of Drd1a 3 0.44 1.86 2.36
169 INT169300 Phosphorylation of CNR1 4 0.57 2.15 2.31
170 INT54748 Positive_regulation of Localization of OPRD1 2 0.08 0.18 2.3
171 INT95792 Regulation of SSTR1 5 0.57 2.98 2.27
172 INT62415 Binding of Htr7 6 0.47 1.76 2.26
173 INT30372 Regulation of ADRB3 8 0.60 0.57 2.24
174 INT23588 Positive_regulation of CCR1 6 0.67 4.44 2.24
175 INT64505 Localization of Htr2c 3 0.78 0.87 2.24
176 INT18654 Gene_expression of HRH2 9 0.67 5.73 2.19
177 INT55658 Binding of HTR4 8 0.47 2.14 2.19
178 INT24407 Negative_regulation of Binding of Drd1a 3 0.25 0.81 2.18
179 INT113906 Regulation of Positive_regulation of CCL2 4 0.27 3.2 2.17
180 INT34500 Positive_regulation of ADRB3 12 0.58 2.59 2.16
181 INT49769 Binding of SSTR2 4 0.48 1.39 2.14
182 INT70481 Regulation of HTR1F 2 0.60 1.55 2.1
183 INT71487 Positive_regulation of HTR7 3 0.67 0.73 2.06
184 INT21046 Regulation of Positive_regulation of Drd1a 3 0.44 0.09 2.06
185 INT113907 Regulation of Localization of CCL2 5 0.62 2.46 2.05
186 INT63627 Transcription of HTR7 5 0.67 0.79 2.03
187 INT67982 Positive_regulation of Positive_regulation of OPRD1 3 0.04 0.33 2.02
188 INT13837 Negative_regulation of Positive_regulation of Drd1a 2 0.43 1.43 2.01
189 INT35485 Regulation of PTGIR 7 0.19 4.5 2
190 INT31096 Binding of HRH2 7 0.37 2 2
191 INT1650 Regulation of TSHR 3 0.28 0.88 1.99
192 INT32980 Positive_regulation of Regulation of OPRM1 2 0.45 0 1.98
193 INT238917 Transcription of CNR2 6 0.62 4.26 1.96
194 INT100490 Negative_regulation of Positive_regulation of CCL2 6 0.23 1.48 1.96
195 INT64682 Positive_regulation of Gene_expression of NPY 4 0.49 3.19 1.96
196 INT117116 Positive_regulation of Positive_regulation of MC1R 7 0.49 1.57 1.91
197 INT7003 Negative_regulation of Binding of OPRD1 4 0.13 0.83 1.9
198 INT161098 Regulation of Positive_regulation of CNR1 3 0.45 2.22 1.87
199 INT67980 Positive_regulation of Positive_regulation of CCL2 7 0.49 5.89 1.85
200 INT69704 Positive_regulation of Binding of MC1R 2 0.50 1.44 1.85
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