GO:0007188

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Name G-protein signaling, coupled to cAMP nucleotide second messenger
Categary Process
Go Slim No
Go Link GO:0007188
Unique Molecular Interactions 696
Total Molecular Interactions 1032
Total Single Events 8311
Pain Genes Associated 61

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for G-protein signaling, coupled to cAMP nucleotide second messenger. They are ordered first by their pain relevance and then by number of times they were reported for G-protein signaling, coupled to cAMP nucleotide second messenger. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 0.64 2.12 14.2
2 INT26468 Ghrh Positive_regulation of Localization of Gh 21 0.37 3.26 9.21
3 INT10844 Ghrh Regulation of Gh 13 0.13 4.77 4.71
4 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
5 INT143270 Binding of Cnr1 and Gprasp1 4 0.54 0.64 4.18
6 INT16221 Ghrh Positive_regulation of Gh 8 0.21 1.89 4.08
7 INT11248 Gh Positive_regulation of Ghrh 2 0.26 0.09 4.04
8 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97
9 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
10 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
11 INT264929 Binding of Cnr1 and Gnaz 1 0.18 1.71 2.89
12 INT104219 SCD Positive_regulation of Cnr1 1 0.00 2.67 2.54
13 INT143271 Binding of Gprasp1 and Positive_regulation of Negative_regulation of Cnr1 1 0.78 0.16 2.53
14 INT20411 Ghrh Positive_regulation of Gh1 6 0.56 0.62 2.47
15 INT143272 Binding of CNR1 and Gprasp1 1 0.01 0.17 2.42
16 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
17 INT7367 Ghrh Regulation of Localization of Gh1 5 0.49 1.55 2.25
18 INT198958 Cnr1 Positive_regulation of Kcnj9 1 0.00 0.15 2.24
19 INT18197 Ghrh Positive_regulation of Localization of Ggh 4 0.46 0 2.23
20 INT9180 Ghrh Regulation of Localization of Gh 3 0.24 0.25 2.18
21 INT120319 Ghrh Regulation of Ngf 1 0.25 1.89 2.11
22 INT35502 Ghrh Positive_regulation of Localization of Gnrhr 7 0.57 0.18 2
23 INT264928 Binding of Cnr1 and Hrh1 1 0.01 1.61 1.92
24 INT264922 Binding of Cnr1 and Mors1 1 0.14 0.1 1.71
25 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
26 INT32482 Ghrh Positive_regulation of Prl 3 0.18 0.26 1.62
27 INT264950 Binding of FPR1 and BOC 1 0.11 0.67 1.55
28 INT192081 Igkv11-125 Positive_regulation of Cnr1 1 0.10 0.23 1.51
29 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5
30 INT150069 Cnr1 Regulation of Cnr2 2 0.50 0.83 1.42
31 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
32 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
33 INT34834 Ghrh Positive_regulation of Gene_expression of Gh1 2 0.65 0 1.4
34 INT356317 Crhr1 Regulation of Gene_expression of Cea 1 0.18 0.65 1.33
35 INT356326 Crhr1 Regulation of Gene_expression of Helt 1 0.01 0.65 1.32
36 INT355252 Binding of Cacna1a and Cnr1 1 0.04 0 1.31
37 INT198957 Binding of Cnr1 and Mastl 1 0.00 0 1.31
38 INT192080 Foxm1 Positive_regulation of Cnr1 2 0.14 0.72 1.3
39 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
40 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
41 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
42 INT88635 Ptger3 Positive_regulation of Localization of Calca 2 0.05 0 1.24
43 INT124874 Gnat3 Positive_regulation of Localization of Calca 2 0.08 0.75 1.2
44 INT210982 Binding of Cnr1 and Cfp 2 0.22 1.27 1.2
45 INT63384 Binding of Cnr1 and Insrr 1 0.03 0.24 1.2
46 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
47 INT152428 Ghrh Positive_regulation of Pde6b 1 0.07 0.5 1.18
48 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
49 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
50 INT212815 WAS Positive_regulation of CNR1 1 0.01 0.62 1.16
51 INT212824 WAS Positive_regulation of Cnr1 1 0.21 0.62 1.16
52 INT19535 Binding of ADRA1D and ALB 3 0.42 0.8 1.15
53 INT32480 Gh1 Positive_regulation of Gene_expression of Ghrh 1 0.35 0 1.15
54 INT264930 Gnaz Positive_regulation of Negative_regulation of Cnr1 1 0.20 0 1.14
55 INT225104 CNR1 Positive_regulation of Gene_expression of RETNLB 1 0.01 1.41 1.14
56 INT110671 Binding of Cnr1 and Alox5 1 0.07 0.2 1.13
57 INT123454 CNR1 Regulation of Fos 1 0.00 0.06 1.12
58 INT123455 CNR1 Regulation of Positive_regulation of Fos 1 0.00 0.06 1.12
59 INT264931 Binding of Gnaz and Hrh1 1 0.01 0.83 1.12
60 INT209088 Binding of Ceacam3 and Crhr1 1 0.34 1.26 1.11
61 INT81788 Binding of AGRP and MC4R 4 0.51 0 1.09
62 INT5106 Gal Positive_regulation of Localization of Ghrh 1 0.21 0 1.07
63 INT120317 Ghrh Regulation of Positive_regulation of Ngf 1 0.25 0.95 1.06
64 INT120311 Ghrh Regulation of Gene_expression of Ngf 1 0.25 0.95 1.06
65 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
66 INT120316 Ghrh Regulation of Il6 1 0.11 0.95 1.05
67 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
68 INT120310 Ghrh Regulation of Positive_regulation of Il6 1 0.18 0.95 1.05
69 INT30905 SST Negative_regulation of Localization of GCG 2 0.12 1.56 1.04
70 INT101443 Penk Positive_regulation of Localization of Gcg 1 0.50 1.21 1.04
71 INT118859 GNA14 Positive_regulation of STAT3 1 0.01 0.38 1.03
72 INT182561 Ptger3 Positive_regulation of Ptger1 1 0.15 1.31 1.02
73 INT182556 Ptger4 Positive_regulation of Ptgir 1 0.08 1.31 1.02
74 INT182567 Ptger4 Positive_regulation of Ptger1 1 0.15 1.31 1.02
75 INT182566 Ptger3 Positive_regulation of Ptgir 1 0.08 1.31 1.02
76 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1
77 INT351443 Cnr1 Regulation of Positive_regulation of Vta1 1 0.12 0.93 0.99
78 INT113743 Mc3r Regulation of Gene_expression of Agrp 1 0.05 0.9 0.98
79 INT19758 Ghrh Positive_regulation of Positive_regulation of Gh 1 0.26 0 0.98
80 INT86960 ADRA1D Negative_regulation of Prl 1 0.00 0 0.97
81 INT25272 Binding of Ggh and Ghrh 1 0.22 0 0.97
82 INT5108 Gal Positive_regulation of Ghrh 1 0.21 0 0.96
83 INT31108 Ghrh Negative_regulation of Gh1 2 0.55 0 0.95
84 INT295530 Ghrl Regulation of Gene_expression of Ghrh 1 0.30 0.21 0.95
85 INT264926 Binding of Gnaz and Pag1 1 0.08 0.19 0.94
86 INT62106 Ghrh Negative_regulation of Localization of Gh 1 0.06 0 0.94
87 INT264932 D2Mit212 Positive_regulation of Binding of Cnr1 1 0.06 0.2 0.94
88 INT35252 Gene_expression of Ghrh Positive_regulation of Localization of Gh1 1 0.49 0 0.93
89 INT120380 Cnr1 Positive_regulation of Gene_expression of Fos 1 0.31 0.45 0.93
90 INT13193 FPR1 Positive_regulation of ELANE 3 0.44 1.22 0.92
91 INT111078 Binding of Cnr1 and Cnr2 2 0.05 0 0.92
92 INT128655 ITIH4 Regulation of Gene_expression of CCR3 1 0.36 1.45 0.92
93 INT72917 Binding of Crh and Crhr1 4 0.32 0.73 0.91
94 INT295547 Ghrl Regulation of Ghrh 1 0.30 0.06 0.9
95 INT30411 Ghrh Regulation of Gene_expression of Gh1 1 0.40 0.12 0.9
96 INT62111 SLC25A4 Negative_regulation of Regulation of Ghrh 1 0.41 0 0.9
97 INT301079 Binding of GNAT1 and INPP5E 1 0.00 0.59 0.89
98 INT337899 Positive_regulation of MC3R Positive_regulation of Gene_expression of Bdnf 1 0.31 0 0.87
99 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
100 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86
101 INT124878 Gnat3 Negative_regulation of Gene_expression of FOS 1 0.09 0.16 0.85
102 INT36008 Negative_regulation of Binding of Drd2 and Prl 1 0.01 2.11 0.85
103 INT15730 Ghrh Positive_regulation of Gnrhr 2 0.14 0.08 0.84
104 INT264925 D2Mit212 Negative_regulation of Cnr1 1 0.05 0 0.84
105 INT106457 SPOP Positive_regulation of Negative_regulation of ADRA1D 1 0.02 0.56 0.84
106 INT124877 Gnat3 Negative_regulation of FOS 1 0.09 0.15 0.82
107 INT124876 Gnat3 Negative_regulation of Positive_regulation of FOS 1 0.09 0.15 0.82
108 INT72418 Binding of Cnr1 and Cnr2 3 0.42 0.07 0.79
109 INT128180 Gna12 Regulation of Regulation of RHOA 1 0.00 0 0.78
110 INT16491 Binding of ADRA1D and Serpinf2 1 0.02 0.78 0.78
111 INT111361 Cnr1 Negative_regulation of Localization of Calca 1 0.01 0 0.78
112 INT16498 Binding of ADRA1D and LPA 1 0.10 0.78 0.78
113 INT16493 Positive_regulation of Binding of ADRA1D and Serpinf2 1 0.02 0.78 0.78
114 INT16497 Positive_regulation of Binding of ADRA1D and LPA 1 0.10 0.78 0.78
115 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77
116 INT33995 Ghrh Regulation of Gnrhr 2 0.18 0.43 0.77
117 INT81976 Binding of GNA15 and OPRL1 1 0.02 0 0.77
118 INT334833 Binding of Drd2 and Ncs1 1 0.05 1.11 0.76
119 INT226122 Ghrl Regulation of Cnr1 1 0.25 0.09 0.76
120 INT118854 GNA14 Positive_regulation of Positive_regulation of STAT3 1 0.02 0.31 0.76
121 INT140790 Positive_regulation of Ptger3 Negative_regulation of Negative_regulation of Bdkrb2 1 0.00 0.07 0.76
122 INT151339 Positive_regulation of Binding of Drd2 and P9Ehs1 1 0.11 0.22 0.76
123 INT152429 Ghrh Positive_regulation of Localization of Gh 4 0.37 0.56 0.75
124 INT151340 Binding of Drd2 and P9Ehs1 1 0.09 0.22 0.75
125 INT292598 CNR1 Regulation of ABAT 1 0.08 0.32 0.75
126 INT166414 Gprasp1 Regulation of Negative_regulation of Cnr1 1 0.37 0.3 0.75
127 INT81011 CNR1 Positive_regulation of Gene_expression of PENK 1 0.54 0 0.75
128 INT292599 CNR1 Regulation of Localization of ABAT 1 0.08 0.32 0.75
129 INT127584 Binding of CNR1 and Ctbp1 1 0.00 0.6 0.75
130 INT245572 Binding of AVPR2 and SPECC1 1 0.10 0.75 0.75
131 INT144455 Binding of CNR1 and GPM6A 1 0.02 0 0.74
132 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
133 INT31306 Ghrh Regulation of Localization of Gnrhr 2 0.14 1 0.73
134 INT31642 POMC Regulation of GCG 1 0.41 0.62 0.73
135 INT101676 Sst Negative_regulation of Localization of Gcg 1 0.03 0 0.72
136 INT290548 Positive_regulation of Crhr1 Positive_regulation of Etf1 1 0.01 0.38 0.72
137 INT101444 Penk Regulation of Localization of Gcg 1 0.45 0.77 0.71
138 INT102123 Ngf Regulation of Gene_expression of Cnr1 1 0.53 0.42 0.71
139 INT29999 Binding of Ptger3 and Retnlb 1 0.00 0 0.71
140 INT155610 FPR1 Positive_regulation of Phosphorylation of SGSM3 1 0.04 0.68 0.71
141 INT102121 Gdnf Regulation of Gene_expression of Cnr1 1 0.45 0.42 0.71
142 INT31307 Ghrh Regulation of Gh1 3 0.27 1.36 0.7
143 INT30125 Binding of Gh and Ghrh 2 0.06 0.36 0.7
144 INT64070 Tp63 Regulation of Ghrh 1 0.04 0.06 0.69
145 INT150067 Cnr1 Regulation of Gene_expression of Oprd1 1 0.01 0.23 0.69
146 INT307046 Tmie Positive_regulation of Cnr1 1 0.05 0.31 0.69
147 INT120381 Binding of CNR1 and Fos 1 0.00 0.52 0.68
148 INT210983 Calb1 Positive_regulation of Cnr1 1 0.01 0.81 0.68
149 INT122190 Binding of Crhr1 and Ucn 4 0.49 0.65 0.67
150 INT264927 Cnr1 Regulation of Gnaz 1 0.23 0.05 0.66
151 INT5105 Gal Regulation of Localization of Ghrh 1 0.19 0 0.66
152 INT213895 Mastl Regulation of Gene_expression of Cnr1 1 0.17 0.26 0.66
153 INT128978 Cnr1 Positive_regulation of Cnr2 1 0.56 0.96 0.65
154 INT31416 Cacna1a Positive_regulation of Gene_expression of Gcg 1 0.03 0 0.65
155 INT31418 Positive_regulation of Adra2c Positive_regulation of Gcg 1 0.22 0 0.65
156 INT18231 Binding of ADRA1D and HP 2 0.14 0.17 0.64
157 INT264943 Negative_regulation of Binding of FPR1 and BOC 1 0.13 0.22 0.64
158 INT356329 Crhr1 Regulation of Cea 1 0.09 0.31 0.64
159 INT264946 Binding of FPR1 and GOPC 1 0.08 0.21 0.64
160 INT110342 Binding of CNR1 and TRPV1 1 0.33 0 0.63
161 INT356314 Binding of Crhr1 and ORF61 1 0.00 0 0.63
162 INT281078 Prkacb Positive_regulation of Gene_expression of Adcy1 1 0.03 0 0.63
163 INT281090 Prkacb Positive_regulation of Mapk1 1 0.06 0 0.62
164 INT62249 Ghrh Regulation of Adrb1 1 0.00 0 0.62
165 INT209131 Binding of Bcl2a1a and Drd2 1 0.22 0.45 0.62
166 INT281091 Prkacb Positive_regulation of Mdk 1 0.02 0 0.62
167 INT30902 GCG Positive_regulation of Localization of SST 1 0.11 0.05 0.62
168 INT19011 Binding of Ghrh and Ghsr 1 0.40 0 0.62
169 INT61507 Ghrhr Positive_regulation of Localization of Gh1 1 0.41 0 0.61
170 INT111839 Binding of Cnr1 and Cnr2 1 0.05 0.53 0.6
171 INT169299 CNR1 Positive_regulation of Localization of IL8 1 0.20 0.11 0.59
172 INT169291 CNR1 Positive_regulation of Gene_expression of PTPLA 1 0.19 0.11 0.59
173 INT169292 Positive_regulation of CNR1 Positive_regulation of Gene_expression of PTPLA 1 0.19 0.11 0.59
174 INT169290 CNR1 Positive_regulation of Negative_regulation of TXK 1 0.10 0.18 0.58
175 INT169286 CNR1 Positive_regulation of Phosphorylation of EGFR 1 0.45 0.18 0.57
176 INT215176 Ptger2 Regulation of Ptger3 2 0.09 1.16 0.56
177 INT203033 Cnr1 Regulation of Cnr2 1 0.15 0.29 0.56
178 INT191762 FPR1 Positive_regulation of Gene_expression of IGKV1D-39 1 0.01 0.84 0.56
179 INT356321 Positive_regulation of Crhr1 Positive_regulation of Cea 1 0.19 0.37 0.56
180 INT45258 SLAMF6 Positive_regulation of Drd2 1 0.00 0 0.55
181 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
182 INT69566 Positive_regulation of Ghrh Regulation of Gh 1 0.04 1.66 0.55
183 INT32478 Gh1 Regulation of Gene_expression of Ghrh 1 0.28 0 0.55
184 INT271889 Binding of DRD2 and ANKK1 1 0.23 0.36 0.55
185 INT271888 Binding of DRD2 and DNAJC7 1 0.14 0.36 0.55
186 INT59635 Binding of Adarb1 and Gnaz 1 0.01 0 0.55
187 INT308895 Adp Positive_regulation of P2ry12 1 0.14 0.11 0.55
188 INT311179 CNR1 Negative_regulation of Transcription of CNR2 1 0.41 2.05 0.55
189 INT356322 Positive_regulation of Crhr1 Positive_regulation of ORF61 1 0.00 0 0.54
190 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54
191 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
192 INT55873 Binding of ADRA1D and GNRH1 1 0.08 0 0.54
193 INT141072 GPRASP1 Positive_regulation of Negative_regulation of CNR1 1 0.56 0.09 0.54
194 INT30959 Ghrh Positive_regulation of Localization of SST 1 0.01 0 0.54
195 INT155359 CNR2 Negative_regulation of CNR1 1 0.46 0.5 0.54
196 INT55872 Binding of ADRA1D and CRH 1 0.26 0 0.54
197 INT156517 Binding of CNR1 and FAAH 3 0.38 1.53 0.53
198 INT167194 FPR1 Positive_regulation of Gene_expression of ITGAM 1 0.52 0.8 0.53
199 INT25414 Positive_regulation of Drd2 Positive_regulation of Penk 1 0.38 0 0.53
200 INT13191 FPR1 Positive_regulation of Localization of GUSB 1 0.31 0 0.53

Single Events

The table below shows the top 100 pain related interactions that have been reported for G-protein signaling, coupled to cAMP nucleotide second messenger. They are ordered first by their pain relevance and then by number of times they were reported in G-protein signaling, coupled to cAMP nucleotide second messenger. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34
2 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49
3 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7
4 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33
5 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84
6 INT5095 Localization of Ghrh 185 0.81 28.09 62.08
7 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75
8 INT62630 Positive_regulation of CNR1 86 0.70 40.34 51.51
9 INT63383 Binding of Cnr1 77 0.48 22.28 44.61
10 INT16194 Binding of CNR1 82 0.48 20.75 39.59
11 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
12 INT12608 Regulation of CNR1 62 0.60 24.36 36.02
13 INT13501 Binding of Drd2 65 0.48 23.76 35.6
14 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52
15 INT50308 Binding of Cnr1 61 0.48 14.41 33.52
16 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
17 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
18 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11
19 INT1473 Localization of Gcg 95 0.80 17.35 30.31
20 INT5100 Positive_regulation of Ghrh 100 0.64 24.2 30.21
21 INT111359 Localization of Cnr1 55 0.81 11.25 27.41
22 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
23 INT75418 Negative_regulation of Cnr1 41 0.59 14.65 27.28
24 INT17625 Localization of GCG 210 0.80 55.69 24.97
25 INT74377 Regulation of Cnr1 38 0.59 16.93 24.77
26 INT12484 Binding of Drd2 45 0.48 15.17 24.72
27 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78
28 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
29 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87
30 INT49774 Binding of DRD2 48 0.48 17.42 20.73
31 INT6699 Positive_regulation of ADRA1D 65 0.70 22.72 20.31
32 INT10442 Negative_regulation of CNR1 47 0.59 20.88 20.2
33 INT79955 Localization of Cnr1 26 0.81 8.44 19.06
34 INT7364 Regulation of Ghrh 49 0.58 8.05 19.05
35 INT9179 Positive_regulation of Localization of Ghrh 42 0.70 7.05 18.1
36 INT87932 Positive_regulation of Gene_expression of Cnr1 28 0.69 8.86 16.38
37 INT62629 Localization of CNR1 35 0.76 11.86 16.3
38 INT9751 Localization of Crhr1 26 0.78 10.47 15.69
39 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
40 INT7523 Regulation of ADRA1D 42 0.45 11.63 14.52
41 INT7366 Negative_regulation of Ghrh 42 0.58 7.72 14.45
42 INT74375 Positive_regulation of Gene_expression of Cnr1 24 0.70 14.25 13.66
43 INT148301 Gene_expression of P2ry12 23 0.75 14.24 13.63
44 INT16530 Gene_expression of Ghrh 45 0.77 6.22 13.44
45 INT6575 Positive_regulation of Localization of Gcg 33 0.69 3.48 13.31
46 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
47 INT14997 Positive_regulation of FPR1 21 0.66 9.82 13.2
48 INT69763 Positive_regulation of Positive_regulation of Cnr1 12 0.50 9.05 12.46
49 INT89181 Gene_expression of Mc3r 33 0.77 22.48 11.85
50 INT2586 Positive_regulation of Gcg 35 0.70 9.25 11.75
51 INT23122 Gene_expression of Ptger3 31 0.72 11.94 11.37
52 INT104039 Positive_regulation of Crhr1 15 0.70 8.34 10.99
53 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
54 INT19010 Negative_regulation of Localization of Ghrh 27 0.57 4.85 10.5
55 INT102525 Gene_expression of CCR3 24 0.71 16.19 10
56 INT106565 Negative_regulation of Gene_expression of Cnr1 19 0.59 6.98 9.93
57 INT6651 Localization of FPR1 18 0.73 3.27 9.9
58 INT8740 Localization of Gcg 65 0.78 19 9.81
59 INT4494 Regulation of GCG 41 0.45 18.38 9.68
60 INT68960 Gene_expression of Ptger4 42 0.67 15.75 9.64
61 INT2828 Positive_regulation of Ptger3 26 0.68 8.01 9.63
62 INT26492 Negative_regulation of Localization of GCG 73 0.58 22.2 9.48
63 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
64 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
65 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
66 INT15991 Gene_expression of FPR1 27 0.59 8.22 9.01
67 INT7572 Regulation of Crhr1 8 0.45 5.6 8.93
68 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
69 INT29411 Positive_regulation of ADRB2 13 0.65 5.42 8.78
70 INT3658 Regulation of Gcg 28 0.53 12.89 8.58
71 INT15529 Gene_expression of GCG 51 0.75 18.55 8.35
72 INT12463 Binding of FPR1 21 0.48 3.16 7.98
73 INT10444 Positive_regulation of Gene_expression of CNR1 18 0.69 8.69 7.84
74 INT264910 Positive_regulation of Gnaz 1 0.30 0 7.82
75 INT11568 Gene_expression of ADORA2A 14 0.73 1.51 7.79
76 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
77 INT7570 Transcription of Crhr1 7 0.66 6.6 7.6
78 INT2587 Regulation of Localization of Gcg 22 0.60 1.73 7.59
79 INT298 Negative_regulation of ADRB3 23 0.59 6.82 7.56
80 INT87976 Regulation of Gene_expression of Cnr1 9 0.58 6.87 7.51
81 INT74326 Gene_expression of Crhr1 25 0.66 9.7 7.48
82 INT6652 Negative_regulation of FPR1 11 0.42 5.29 7.41
83 INT49932 Gene_expression of Ptger3 33 0.71 8.77 7.39
84 INT3659 Negative_regulation of Gcg 26 0.51 10.08 7.39
85 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
86 INT7883 Binding of ADRB2 18 0.47 5.49 7.37
87 INT80161 Positive_regulation of Crhr1 13 0.67 9.66 7.33
88 INT86898 Negative_regulation of Gene_expression of Cnr1 13 0.55 3.33 7.25
89 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
90 INT96969 Positive_regulation of Positive_regulation of CNR1 9 0.48 1.27 7.19
91 INT186142 Gene_expression of Ghrh 45 0.66 34.04 6.94
92 INT256 Localization of ADRA1D 11 0.78 2.91 6.85
93 INT7925 Transcription of Ghrh 13 0.67 2.36 6.77
94 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
95 INT9753 Positive_regulation of Localization of Crhr1 8 0.49 1.72 6.55
96 INT50130 Positive_regulation of Ptger3 13 0.67 5.23 6.47
97 INT24460 Localization of Drd2 12 0.73 2.96 6.46
98 INT10445 Transcription of CNR1 16 0.68 6.75 6.4
99 INT85655 Gene_expression of Crhr1 17 0.68 9.34 6.31
100 INT148308 Regulation of P2ry12 8 0.44 6.2 6.23
101 INT86772 Localization of Drd2 14 0.80 1.93 6.17
102 INT233812 Gene_expression of PTH1R 32 0.77 18.15 6.15
103 INT15528 Positive_regulation of GCG 38 0.63 20.47 6.14
104 INT262 Localization of Ptger3 17 0.61 3.03 6.1
105 INT1493 Positive_regulation of Prkacb 8 0.59 2.75 5.99
106 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
107 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
108 INT3894 Negative_regulation of Localization of Gcg 18 0.52 2.7 5.77
109 INT85404 Transcription of Cnr1 12 0.72 3.15 5.73
110 INT31227 Regulation of Localization of GCG 28 0.48 4.86 5.72
111 INT1243 Regulation of ADRB2 16 0.54 1.84 5.66
112 INT34742 Gene_expression of Gnat3 44 0.67 6.83 5.65
113 INT7361 Binding of Ghrh 13 0.45 1.37 5.44
114 INT90961 Negative_regulation of Positive_regulation of Cnr1 7 0.42 0.6 5.24
115 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
116 INT9178 Regulation of Localization of Ghrh 13 0.45 2.28 5.08
117 INT29893 Negative_regulation of Prkacb 4 0.37 1.14 5.04
118 INT80712 Gene_expression of PTGER4 21 0.65 13.08 5.03
119 INT90962 Regulation of Positive_regulation of Cnr1 6 0.61 1.25 4.99
120 INT14681 Negative_regulation of GCG 31 0.57 13.55 4.98
121 INT88062 Gene_expression of Ptger4 13 0.77 2.4 4.94
122 INT105608 Positive_regulation of Mc3r 9 0.68 8.53 4.83
123 INT18245 Negative_regulation of Localization of Crhr1 4 0.17 0.28 4.81
124 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
125 INT7568 Negative_regulation of Crhr1 8 0.43 4.63 4.77
126 INT105403 Positive_regulation of Gene_expression of CCR3 10 0.60 7.99 4.74
127 INT19008 Positive_regulation of Positive_regulation of Ghrh 15 0.49 2.4 4.55
128 INT111358 Regulation of Localization of Cnr1 3 0.39 0.09 4.53
129 INT1490 Regulation of Prkacb 7 0.21 0.5 4.52
130 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
131 INT74373 Phosphorylation of Cnr1 3 0.79 1.88 4.45
132 INT8743 Positive_regulation of Gcg 19 0.65 10.63 4.43
133 INT1634 Gene_expression of Gcg 25 0.75 14.98 4.42
134 INT88059 Positive_regulation of Ptger4 9 0.69 1.41 4.4
135 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
136 INT8744 Regulation of Localization of Gcg 14 0.60 2.06 4.3
137 INT64448 Gene_expression of Mc3r 7 0.74 3.27 4.3
138 INT150464 Positive_regulation of P2ry12 5 0.67 4.39 4.3
139 INT34829 Positive_regulation of Gnat3 27 0.46 5.24 4.14
140 INT4104 Gene_expression of ADRB3 19 0.78 2.68 4.12
141 INT165182 Gene_expression of P2ry12 4 0.65 4.29 4.08
142 INT17626 Positive_regulation of Localization of GCG 36 0.69 13.94 4.06
143 INT90983 Regulation of Gene_expression of Cnr1 8 0.45 2.59 4.03
144 INT87974 Transcription of Cnr1 15 0.65 2.51 4.02
145 INT113204 Negative_regulation of Positive_regulation of Cnr1 6 0.40 4.89 4.02
146 INT142059 Regulation of Ghrh 15 0.59 3.25 3.94
147 INT484 Negative_regulation of ADRB2 13 0.59 2.85 3.94
148 INT109 Binding of ADRB3 17 0.47 3.02 3.84
149 INT76707 Negative_regulation of Gene_expression of Ptger3 6 0.20 2.56 3.73
150 INT12707 Negative_regulation of Binding of FPR1 9 0.59 1.45 3.72
151 INT95556 Negative_regulation of Binding of Cnr1 5 0.58 3.1 3.67
152 INT84005 Negative_regulation of Positive_regulation of CNR1 7 0.41 3.55 3.66
153 INT25136 Localization of Gnat3 23 0.75 5.01 3.65
154 INT80923 Negative_regulation of Binding of CNR1 7 0.19 0.78 3.61
155 INT27694 Positive_regulation of Positive_regulation of ADRA1D 10 0.70 1.52 3.57
156 INT85537 Regulation of Crhr1 4 0.45 1.64 3.53
157 INT8748 Positive_regulation of Localization of Gcg 24 0.67 9.74 3.46
158 INT236824 Negative_regulation of Gene_expression of PTH1R 10 0.58 9.3 3.42
159 INT12388 Negative_regulation of Crhr1 17 0.59 9.47 3.33
160 INT183249 Binding of P2ry12 12 0.47 7.4 3.3
161 INT31414 Gene_expression of Gcg 25 0.73 7.28 3.25
162 INT119470 Regulation of Ptger4 6 0.43 3.94 3.24
163 INT127336 Positive_regulation of Transcription of Crhr1 3 0.48 3.37 3.19
164 INT102209 Negative_regulation of Gene_expression of Drd2 5 0.59 0.46 3.17
165 INT148306 Transcription of P2ry12 4 0.69 2.45 3.14
166 INT66599 Gene_expression of MC4R 16 0.78 12.37 3.12
167 INT10443 Regulation of Gene_expression of CNR1 10 0.50 3.96 3.06
168 INT106283 Regulation of Positive_regulation of Cnr1 3 0.37 2.61 3.05
169 INT301081 Positive_regulation of GNAT1 1 0.12 4.16 3
170 INT118107 Positive_regulation of Avpr1b 4 0.66 6.89 2.99
171 INT69822 Binding of Ptger3 9 0.39 2.98 2.97
172 INT41474 Gene_expression of ADRB2 10 0.75 1.56 2.94
173 INT19539 Positive_regulation of Gene_expression of ADRA1D 10 0.67 9.4 2.9
174 INT9752 Regulation of Localization of Crhr1 3 0.44 0.36 2.82
175 INT68962 Positive_regulation of Ptger4 20 0.67 7.3 2.79
176 INT111422 Positive_regulation of Regulation of CNR1 3 0.03 0.56 2.76
177 INT26705 Transcription of ADRA1D 6 0.67 3.99 2.74
178 INT66630 Transcription of Ptger3 4 0.67 1.74 2.74
179 INT143189 Positive_regulation of Binding of Cnr1 3 0.35 0.37 2.74
180 INT90982 Regulation of Transcription of Cnr1 3 0.26 1.37 2.7
181 INT11196 Negative_regulation of Gnat3 26 0.37 3.14 2.69
182 INT264915 Positive_regulation of Localization of Gnaz 1 0.19 0 2.68
183 INT74556 Negative_regulation of Binding of Cnr1 4 0.59 1.13 2.67
184 INT215029 Negative_regulation of Ghrh 15 0.56 11.37 2.62
185 INT20028 Positive_regulation of Gene_expression of Ghrh 9 0.50 1.52 2.62
186 INT166411 Positive_regulation of Negative_regulation of Cnr1 4 0.50 0.84 2.62
187 INT108468 Negative_regulation of Gene_expression of Drd2 3 0.41 0.67 2.58
188 INT77213 Transcription of ADORA2A 1 0.69 0 2.55
189 INT97807 Negative_regulation of Regulation of CNR1 2 0.09 0.89 2.51
190 INT172592 Positive_regulation of PTH1R 9 0.28 6.25 2.5
191 INT169785 Localization of Ptger3 9 0.57 1.35 2.5
192 INT125345 Positive_regulation of Localization of Cnr1 6 0.50 1.47 2.44
193 INT152163 Positive_regulation of GALR2 4 0.70 3.69 2.43
194 INT15993 Regulation of FPR1 8 0.40 1.24 2.42
195 INT166412 Protein_catabolism of Cnr1 4 0.99 0.9 2.37
196 INT169300 Phosphorylation of CNR1 4 0.57 2.15 2.31
197 INT30372 Regulation of ADRB3 8 0.60 0.57 2.24
198 INT76160 Phosphorylation of Prkacb 4 0.09 0.19 2.24
199 INT16527 Negative_regulation of Positive_regulation of Ghrh 6 0.43 1.01 2.23
200 INT76706 Positive_regulation of Gene_expression of Ptger3 5 0.22 0.49 2.23
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