GO:0007189

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Name activation of adenylate cyclase activity by G-protein signaling pathway
Categary Process
Go Slim No
Go Link GO:0007189
Unique Molecular Interactions 1719
Total Molecular Interactions 2903
Total Single Events 29902
Pain Genes Associated 67

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of adenylate cyclase activity by G-protein signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for activation of adenylate cyclase activity by G-protein signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 0.64 2.12 14.2
2 INT69886 Ngf Positive_regulation of Calca 8 0.76 2.98 12.77
3 INT166591 Binding of CALCA and DCLK3 4 0.30 0.69 12.18
4 INT26468 Ghrh Positive_regulation of Localization of Gh 21 0.37 3.26 9.21
5 INT180785 Gdnf Positive_regulation of Calca 1 0.23 1.96 8.04
6 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
7 INT69888 Ngf Positive_regulation of Localization of Calca 4 0.52 0.51 4.95
8 INT102122 Binding of Calca and RT1-M4 7 0.29 5.83 4.94
9 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
10 INT10844 Ghrh Regulation of Gh 13 0.13 4.77 4.71
11 INT24742 Binding of Calca and Vip 1 0.37 0.18 4.68
12 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
13 INT128998 Cxcl1 Positive_regulation of Localization of Calca 1 0.66 2.96 4.15
14 INT16221 Ghrh Positive_regulation of Gh 8 0.21 1.89 4.08
15 INT11248 Gh Positive_regulation of Ghrh 2 0.26 0.09 4.04
16 INT13969 Binding of Calca and Sst 3 0.32 0.6 4.02
17 INT13966 Calca Positive_regulation of Localization of Sst 5 0.49 0.75 3.91
18 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
19 INT85541 Ngf Positive_regulation of Gene_expression of Calca 2 0.55 1.84 3.71
20 INT87491 CALCA Positive_regulation of Gene_expression of IL8 1 0.72 0.92 3.52
21 INT24710 Binding of Calca and SUB1P1 1 0.01 2.09 3.48
22 INT108471 Binding of CALCA and PNOC 1 0.29 0.64 3.25
23 INT74159 Ngf Regulation of Gene_expression of Calca 2 0.60 1.66 3.22
24 INT13729 GHRH Positive_regulation of Localization of GH1 13 0.62 0.59 3.2
25 INT29657 Binding of Calca and Calcb 1 0.26 0 3.16
26 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01
27 INT100835 Binding of Calca and Akap12 1 0.07 0.41 2.92
28 INT166592 Binding of CALCA and RAMP1 2 0.35 0.33 2.91
29 INT73821 CALCA Positive_regulation of Localization of IL8 1 0.25 2.37 2.91
30 INT194409 Binding of CALCA and IGKV1D-8 1 0.15 0 2.84
31 INT169134 Binding of Calca and Trpa1 1 0.37 3.37 2.79
32 INT180779 Bdnf Regulation of Calca 1 0.09 0.23 2.71
33 INT53648 Acot1 Positive_regulation of Localization of Calca 2 0.23 0 2.61
34 INT57624 Calca Regulation of Positive_regulation of Trh 1 0.50 0 2.53
35 INT48526 Binding of Calca and Penk 1 0.24 1.03 2.51
36 INT20411 Ghrh Positive_regulation of Gh1 6 0.56 0.62 2.47
37 INT136129 Calca Positive_regulation of ATP8A2 1 0.38 0.89 2.4
38 INT13967 Calca Positive_regulation of Sst 1 0.45 0 2.3
39 INT152900 TRPV1 Regulation of Gene_expression of CALCA 1 0.69 0.73 2.29
40 INT152901 TRPV1 Regulation of Localization of CALCA 1 0.44 0.73 2.29
41 INT7367 Ghrh Regulation of Localization of Gh1 5 0.49 1.55 2.25
42 INT18197 Ghrh Positive_regulation of Localization of Ggh 4 0.46 0 2.23
43 INT69887 Ngf Regulation of Calca 2 0.49 0.1 2.19
44 INT9180 Ghrh Regulation of Localization of Gh 3 0.24 0.25 2.18
45 INT120319 Ghrh Regulation of Ngf 1 0.25 1.89 2.11
46 INT79470 Mgat4a Regulation of Localization of Calca 1 0.08 1.72 2.1
47 INT89733 Binding of Calca and Nrm 1 0.31 0.71 2.09
48 INT63873 SRPX Positive_regulation of Localization of Calca 1 0.02 0.49 2.04
49 INT115042 Gdnf Regulation of Calca 1 0.53 0.25 2.03
50 INT26221 Calca Regulation of Gt(pU21)50Imeg 1 0.01 0 2.02
51 INT35502 Ghrh Positive_regulation of Localization of Gnrhr 7 0.57 0.18 2
52 INT128996 Ccl2 Positive_regulation of Localization of Calca 1 0.68 1.43 2
53 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99
54 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92
55 INT24942 Calca Regulation of TAC1 1 0.13 0.7 1.89
56 INT271408 NGF Positive_regulation of Gene_expression of CALCA 1 0.09 4.89 1.88
57 INT168723 Positive_regulation of Trpv1 Positive_regulation of Gene_expression of Calca 1 0.48 1.1 1.84
58 INT16891 GHRH Regulation of GH1 5 0.37 1.94 1.82
59 INT163514 Ngf Positive_regulation of Gene_expression of Calca 1 0.30 2.21 1.82
60 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
61 INT24934 Calca Regulation of Nka1 3 0.05 0.43 1.73
62 INT148090 Binding of CALCA and NCOR2 1 0.00 0.65 1.71
63 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
64 INT94617 KNG1 Positive_regulation of Localization of Calca 1 0.00 0.75 1.7
65 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
66 INT56134 CALCA Positive_regulation of POMC 2 0.71 0.72 1.68
67 INT102447 Binding of CALCA and CALCRL 2 0.26 0.33 1.67
68 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
69 INT94618 KNG1 Positive_regulation of Calca 1 0.00 0.75 1.66
70 INT144213 Nppa Positive_regulation of Localization of Calca 1 0.71 2.8 1.65
71 INT23889 Calca Positive_regulation of Localization of Tacr1 1 0.11 0.45 1.65
72 INT24157 Binding of CALCA and SFTPA1 2 0.07 0.96 1.64
73 INT138777 Binding of Galr2 and Galr1 1 0.08 1.18 1.64
74 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
75 INT32482 Ghrh Positive_regulation of Prl 3 0.18 0.26 1.62
76 INT160578 Binding of CALCA and TAC1 1 0.07 0.91 1.61
77 INT148935 Ramp1 Regulation of Calca 1 0.27 0.69 1.56
78 INT13968 Calca Negative_regulation of Positive_regulation of Sst 1 0.34 0 1.55
79 INT13970 Positive_regulation of Calca Positive_regulation of Sst 1 0.37 0 1.53
80 INT13965 Calca Positive_regulation of Positive_regulation of Sst 1 0.37 0 1.53
81 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5
82 INT96784 Binding of CALCA and Calca 3 0.23 0.27 1.47
83 INT180791 Negative_regulation of Gdnf Regulation of Calca 1 0.17 0 1.47
84 INT180767 Bdnf Positive_regulation of Gene_expression of Calca 1 0.17 0 1.45
85 INT276681 Calca Regulation of Nav1 1 0.07 0.74 1.45
86 INT276686 Calca Regulation of Nav1 1 0.26 0.74 1.45
87 INT84434 Calca Negative_regulation of Negative_regulation of Hrh1 1 0.06 0.19 1.44
88 INT95325 HTR1B Negative_regulation of Calca 1 0.47 0.69 1.43
89 INT134760 Ghrl Regulation of Transcription of Calca 1 0.24 2.71 1.42
90 INT298458 Binding of Calcrl and Adarb1 1 0.00 0.23 1.41
91 INT34834 Ghrh Positive_regulation of Gene_expression of Gh1 2 0.65 0 1.4
92 INT144122 Binding of Calca and P2rx6 1 0.10 0 1.4
93 INT169163 Binding of Calca and Ctbs 1 0.00 0.51 1.4
94 INT51213 Vip Regulation of Localization of Calca 1 0.38 0 1.39
95 INT8719 Npy Negative_regulation of Localization of Calca 1 0.06 0.26 1.39
96 INT168724 Creb1 Negative_regulation of Gene_expression of Calca 1 0.46 1.09 1.38
97 INT168721 Positive_regulation of Creb1 Positive_regulation of Calca 1 0.53 1.07 1.37
98 INT279165 Calca Regulation of Gene_expression of Fdft1 1 0.02 0.41 1.37
99 INT180810 Gopc Positive_regulation of Calca 1 0.02 0.28 1.36
100 INT168722 Creb1 Positive_regulation of Calca 1 0.73 1.05 1.35
101 INT261463 Binding of Drd1a and Sftpd 1 0.12 0.13 1.35
102 INT151771 Binding of P2RX3 and Calca 1 0.04 0.89 1.34
103 INT298455 Calca Positive_regulation of Gene_expression of Ceacam3 1 0.17 0.47 1.34
104 INT356317 Crhr1 Regulation of Gene_expression of Cea 1 0.18 0.65 1.33
105 INT180786 Calca Regulation of Positive_regulation of Ngf 1 0.40 0 1.32
106 INT356326 Crhr1 Regulation of Gene_expression of Helt 1 0.01 0.65 1.32
107 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
108 INT180764 Calca Regulation of Positive_regulation of Gdnf 1 0.21 0 1.32
109 INT180807 Calca Regulation of Sorbs1 1 0.02 0 1.32
110 INT180771 Calca Regulation of Positive_regulation of Bdnf 1 0.18 0 1.32
111 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
112 INT121096 Binding of Calca and Trpv1 3 0.37 1.23 1.29
113 INT148775 Binding of Calca and Usf1 1 0.43 0.85 1.29
114 INT194408 Regulation of Binding of CALCA and DCLK3 1 0.15 0 1.29
115 INT138210 Mzb1 Regulation of Calca 1 0.25 0.41 1.29
116 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
117 INT22501 Binding of Calca and Pth 1 0.21 0.07 1.28
118 INT88635 Ptger3 Positive_regulation of Localization of Calca 2 0.05 0 1.24
119 INT69562 Positive_regulation of AP2M1 Positive_regulation of Regulation of Adrb3 1 0.01 0.19 1.24
120 INT136249 Drd1a Positive_regulation of Phosphorylation of Tff3 1 0.01 0.18 1.23
121 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
122 INT103031 Calca Positive_regulation of Ptgs1 2 0.46 0.98 1.22
123 INT151454 Binding of Calca and Insrr 1 0.02 0.31 1.22
124 INT87586 RPL7AP5 Negative_regulation of Gene_expression of Calca 1 0.00 0.05 1.21
125 INT79471 Mgat4a Regulation of Calca 1 0.06 1.09 1.21
126 INT87585 RPL7AP5 Negative_regulation of Calca 1 0.00 0.05 1.21
127 INT124874 Gnat3 Positive_regulation of Localization of Calca 2 0.08 0.75 1.2
128 INT65203 OPRL1 Negative_regulation of ADCY1 1 0.19 0 1.19
129 INT116730 Rac1 Regulation of Localization of Calca 1 0.13 1.32 1.19
130 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
131 INT152428 Ghrh Positive_regulation of Pde6b 1 0.07 0.5 1.18
132 INT194403 Negative_regulation of Binding of CALCA and DCLK3 1 0.22 0 1.18
133 INT25026 PLOD1 Regulation of FSHR 4 0.19 0.38 1.15
134 INT338053 F2r Positive_regulation of Localization of Calca 1 0.06 0.47 1.15
135 INT91394 Negative_regulation of MMP2 Positive_regulation of CALCA 1 0.25 0.15 1.15
136 INT32480 Gh1 Positive_regulation of Gene_expression of Ghrh 1 0.35 0 1.15
137 INT193288 CAP1 Positive_regulation of Pth 1 0.04 0.08 1.14
138 INT65204 PNOC Negative_regulation of ADCY1 1 0.07 0 1.14
139 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
140 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
141 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
142 INT222516 Binding of Calcrl and Ramp1 5 0.17 0.11 1.12
143 INT32182 PRL Regulation of GHRH 2 0.17 0 1.12
144 INT22176 Calca Regulation of Localization of Prl 4 0.69 0.39 1.11
145 INT4752 Gal Negative_regulation of Localization of Calca 1 0.41 0.06 1.11
146 INT282065 Binding of Calca and Ngf 1 0.14 0.85 1.11
147 INT209088 Binding of Ceacam3 and Crhr1 1 0.34 1.26 1.11
148 INT74185 Cck Negative_regulation of Drd1a 1 0.30 0.1 1.1
149 INT4753 Sst Negative_regulation of Localization of Calca 1 0.39 0.06 1.1
150 INT19887 GHRH Positive_regulation of Positive_regulation of GH1 2 0.56 0.3 1.08
151 INT70495 CALCA Positive_regulation of CALCB 2 0.40 0 1.08
152 INT352453 Calca Positive_regulation of Trib3 1 0.00 0.8 1.08
153 INT69889 Ngf Regulation of Localization of Calca 1 0.49 0.1 1.08
154 INT352468 Calca Positive_regulation of Prkaca 1 0.11 0.8 1.08
155 INT91395 MMP2 Positive_regulation of CALCA 1 0.36 0.17 1.07
156 INT79372 Calca Regulation of Pnoc 1 0.34 0 1.07
157 INT5106 Gal Positive_regulation of Localization of Ghrh 1 0.21 0 1.07
158 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
159 INT139225 Calca Negative_regulation of Icam1 1 0.44 1.13 1.06
160 INT120317 Ghrh Regulation of Positive_regulation of Ngf 1 0.25 0.95 1.06
161 INT120311 Ghrh Regulation of Gene_expression of Ngf 1 0.25 0.95 1.06
162 INT139229 Calca Negative_regulation of Cmklr1 1 0.19 1.12 1.06
163 INT139231 Calca Negative_regulation of Timp1 1 0.36 1.11 1.05
164 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
165 INT120316 Ghrh Regulation of Il6 1 0.11 0.95 1.05
166 INT139226 Icam1 Negative_regulation of Calca 1 0.44 1.12 1.05
167 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
168 INT120310 Ghrh Regulation of Positive_regulation of Il6 1 0.18 0.95 1.05
169 INT48260 Binding of Adcyap1 and Calca 1 0.35 0 1.04
170 INT130167 Trpv1 Regulation of Localization of Calca 2 0.38 0.69 1.03
171 INT86073 Med15 Regulation of Calca 1 0.49 0.2 1.03
172 INT114555 Binding of Calca and St3gal3 1 0.01 0.44 1.03
173 INT182556 Ptger4 Positive_regulation of Ptgir 1 0.08 1.31 1.02
174 INT182567 Ptger4 Positive_regulation of Ptger1 1 0.15 1.31 1.02
175 INT114552 Binding of Calca and Col4a4 1 0.01 0.44 1.02
176 INT51260 Calca Negative_regulation of Nts 1 0.10 0.08 1.01
177 INT51261 Calca Negative_regulation of Sst 1 0.20 0.08 1.01
178 INT7025 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.08 1.01
179 INT298298 Calca Negative_regulation of Gene_expression of Runx1 1 0.19 0.33 1
180 INT112163 Calca Positive_regulation of Mpo 1 0.49 1.23 1
181 INT298274 Gene_expression of Runx1 Negative_regulation of Calca 1 0.19 0.33 1
182 INT162299 Negative_regulation of Adarb1 Negative_regulation of Gene_expression of Calca 1 0.01 0.93 1
183 INT35157 GH1 Regulation of GHRH 3 0.17 0.5 0.99
184 INT53052 ANTXRL Negative_regulation of Negative_regulation of ADCY1 1 0.01 0.66 0.99
185 INT110033 Adrb1 Positive_regulation of Gene_expression of Il12a 1 0.05 0 0.99
186 INT49163 Binding of Pax3 and Calca 1 0.03 0.37 0.98
187 INT19758 Ghrh Positive_regulation of Positive_regulation of Gh 1 0.26 0 0.98
188 INT239539 Binding of CXCR2 and CALCRL 1 0.00 0.38 0.98
189 INT25272 Binding of Ggh and Ghrh 1 0.22 0 0.97
190 INT24395 Binding of CALCA and CLPP 1 0.03 0.17 0.96
191 INT87854 Binding of Drd1a and Positive_regulation of Localization of Abat 1 0.08 0 0.96
192 INT5108 Gal Positive_regulation of Ghrh 1 0.21 0 0.96
193 INT206857 Binding of Calca and Calcrl 4 0.37 1.9 0.95
194 INT31108 Ghrh Negative_regulation of Gh1 2 0.55 0 0.95
195 INT74184 Cck Regulation of Localization of Drd1a 1 0.32 0.06 0.95
196 INT148772 Usf1 Regulation of Calca 1 0.40 0.69 0.95
197 INT295530 Ghrl Regulation of Gene_expression of Ghrh 1 0.30 0.21 0.95
198 INT180787 Calca Regulation of Gdnf 1 0.18 0.28 0.95
199 INT62106 Ghrh Negative_regulation of Localization of Gh 1 0.06 0 0.94
200 INT352447 Gse1 Negative_regulation of Gene_expression of Calca 1 0.03 0.98 0.94

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of adenylate cyclase activity by G-protein signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in activation of adenylate cyclase activity by G-protein signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 2008 0.81 518.3 1408.65
2 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84
3 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08
4 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04
5 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38
6 INT2649 Regulation of Calca 433 0.62 146.05 330.95
7 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45
8 INT626 Localization of CALCA 289 0.81 125.39 221.15
9 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57
10 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2
11 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47
12 INT2541 Binding of Calca 200 0.48 67.14 134.62
13 INT5008 Localization of Calca 204 0.81 80.35 125.16
14 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75
15 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61
16 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03
17 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
18 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9
19 INT5095 Localization of Ghrh 185 0.81 28.09 62.08
20 INT6761 Binding of CALCA 100 0.48 26.71 62.05
21 INT4760 Negative_regulation of Gene_expression of Calca 93 0.59 34.19 60.3
22 INT4241 Regulation of CALCA 87 0.62 28.19 55.29
23 INT4891 Transcription of Calca 81 0.72 35.27 53.75
24 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66
25 INT249 Localization of GHRH 215 0.80 78.02 51.87
26 INT97674 Positive_regulation of Localization of Calca 70 0.69 27.71 51.79
27 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
28 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34
29 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8
30 INT28265 Positive_regulation of Calca 62 0.70 29.1 41.17
31 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52
32 INT8784 Negative_regulation of Positive_regulation of Calca 40 0.59 14.67 33.49
33 INT8746 Negative_regulation of Calca 50 0.59 21.22 33.45
34 INT5100 Positive_regulation of Ghrh 100 0.64 24.2 30.21
35 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76
36 INT22499 Regulation of Calca 42 0.62 17.32 28.02
37 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54
38 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26
39 INT97 Negative_regulation of Adrb1 102 0.59 32.44 26.9
40 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43
41 INT18400 Localization of Glp1r 97 0.80 11.96 24.32
42 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42
43 INT250 Regulation of GHRH 65 0.61 17.46 23.19
44 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51
45 INT1644 Regulation of FSHR 77 0.55 15.62 21.49
46 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74
47 INT7364 Regulation of Ghrh 49 0.58 8.05 19.05
48 INT7680 Regulation of Drd1a 27 0.45 4.52 18.86
49 INT9179 Positive_regulation of Localization of Ghrh 42 0.70 7.05 18.1
50 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51
51 INT22068 Binding of CALCRL 53 0.41 6.14 17.32
52 INT7020 Negative_regulation of Drd1a 25 0.57 1.84 17.1
53 INT125947 Gene_expression of Adora2b 57 0.75 23.69 17
54 INT35998 Positive_regulation of Gene_expression of Calca 31 0.70 16.16 16.98
55 INT984 Positive_regulation of Localization of GHRH 58 0.70 12.66 16.51
56 INT6150 Positive_regulation of Negative_regulation of Calca 20 0.68 4.06 16.26
57 INT12617 Regulation of ADCY1 41 0.61 7.38 15.94
58 INT9751 Localization of Crhr1 26 0.78 10.47 15.69
59 INT5859 Positive_regulation of Positive_regulation of Drd1a 20 0.55 2.05 15.61
60 INT216751 Gene_expression of ADORA2B 36 0.60 3.42 15.6
61 INT912 Localization of FSHR 91 0.79 23.61 15.58
62 INT42810 Gene_expression of CALCRL 53 0.77 10.87 15.42
63 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33
64 INT170 Negative_regulation of Adrb1 52 0.55 13.46 14.78
65 INT663 Negative_regulation of Adrb3 55 0.59 15.95 14.68
66 INT7366 Negative_regulation of Ghrh 42 0.58 7.72 14.45
67 INT95 Positive_regulation of Adrb1 34 0.62 11.95 14.41
68 INT15042 Gene_expression of Adora2a 37 0.77 3.77 14.24
69 INT194850 Positive_regulation of Adora2b 43 0.61 20.57 13.89
70 INT110 Regulation of Adrb3 33 0.60 8.09 13.84
71 INT108063 Gene_expression of Adora2a 29 0.78 13.11 13.78
72 INT16530 Gene_expression of Ghrh 45 0.77 6.22 13.44
73 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04
74 INT65109 Negative_regulation of Transcription of Calca 16 0.59 8.63 12.84
75 INT50227 Positive_regulation of Adora2a 32 0.50 5.17 12.75
76 INT26217 Binding of Calca 22 0.48 5.22 12.57
77 INT63104 Negative_regulation of CALCRL 29 0.37 13.62 12.42
78 INT89248 Positive_regulation of Galr1 14 0.70 6.99 12.3
79 INT11244 Transcription of CALCA 21 0.69 3.61 12.27
80 INT15136 Regulation of Positive_regulation of Calca 12 0.62 3.02 12.16
81 INT11429 Gene_expression of ADCY1 26 0.74 5.89 11.93
82 INT7682 Binding of Drd1a 22 0.48 1.8 11.83
83 INT6151 Negative_regulation of Negative_regulation of Calca 14 0.58 4.86 11.81
84 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7
85 INT72784 Positive_regulation of Adora2a 26 0.70 16.52 11.47
86 INT254 Regulation of Localization of GHRH 30 0.60 5.17 11.46
87 INT40486 Positive_regulation of Positive_regulation of ADCY1 20 0.48 4.29 11.33
88 INT5464 Regulation of CALCRL 24 0.16 4.2 11.19
89 INT104039 Positive_regulation of Crhr1 15 0.70 8.34 10.99
90 INT5779 Positive_regulation of Transcription of Calca 15 0.62 5.61 10.86
91 INT122682 Gene_expression of Galr2 11 0.63 5.06 10.77
92 INT101203 Negative_regulation of Gene_expression of Calca 12 0.59 7.06 10.72
93 INT19010 Negative_regulation of Localization of Ghrh 27 0.57 4.85 10.5
94 INT8188 Positive_regulation of Adrb3 27 0.68 7.32 10.44
95 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34
96 INT12620 Negative_regulation of Negative_regulation of ADCY1 16 0.44 2.98 10.1
97 INT5465 Positive_regulation of CALCRL 25 0.49 7.24 9.8
98 INT59 Regulation of Adrb1 25 0.42 8.32 9.78
99 INT68960 Gene_expression of Ptger4 42 0.67 15.75 9.64
100 INT62919 Regulation of Gnas 22 0.43 5.61 9.55
101 INT30247 Regulation of Adrb1 18 0.44 4.45 8.93
102 INT7572 Regulation of Crhr1 8 0.45 5.6 8.93
103 INT22083 Regulation of Pth 55 0.62 22.32 8.9
104 INT1647 Negative_regulation of FSHR 54 0.45 13.44 8.87
105 INT103251 Negative_regulation of Localization of Calca 13 0.43 9.36 8.86
106 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85
107 INT29411 Positive_regulation of ADRB2 13 0.65 5.42 8.78
108 INT96 Binding of Adrb1 18 0.48 2.8 8.52
109 INT16735 Localization of Drd1a 11 0.61 0.35 8.42
110 INT23209 Binding of Adora2a 17 0.38 2.04 8.35
111 INT8761 Negative_regulation of Binding of Calca 12 0.43 3.59 8.32
112 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24
113 INT953 Positive_regulation of Positive_regulation of GHRH 17 0.67 2.38 8.18
114 INT54681 Negative_regulation of Positive_regulation of ADCY1 16 0.38 2.7 8.14
115 INT26115 Gene_expression of Adrb1 14 0.64 5.13 7.78
116 INT54755 Negative_regulation of Adora2a 17 0.58 2.7 7.75
117 INT23992 Positive_regulation of Adrb1 25 0.56 4.01 7.62
118 INT7570 Transcription of Crhr1 7 0.66 6.6 7.6
119 INT298 Negative_regulation of ADRB3 23 0.59 6.82 7.56
120 INT74326 Gene_expression of Crhr1 25 0.66 9.7 7.48
121 INT7883 Binding of ADRB2 18 0.47 5.49 7.37
122 INT216752 Binding of ADORA2B 17 0.36 0.76 7.36
123 INT25220 Positive_regulation of Binding of Calca 7 0.69 3.78 7.34
124 INT80161 Positive_regulation of Crhr1 13 0.67 9.66 7.33
125 INT51164 Gene_expression of Galr1 12 0.78 6.3 7.3
126 INT124264 Regulation of Localization of Calca 10 0.33 1.39 7.14
127 INT186142 Gene_expression of Ghrh 45 0.66 34.04 6.94
128 INT22369 Negative_regulation of Drd1a 15 0.47 6.13 6.87
129 INT47944 Positive_regulation of Localization of Glp1r 23 0.70 0.16 6.79
130 INT7925 Transcription of Ghrh 13 0.67 2.36 6.77
131 INT9753 Positive_regulation of Localization of Crhr1 8 0.49 1.72 6.55
132 INT47942 Positive_regulation of Glp1r 38 0.70 15.94 6.47
133 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33
134 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33
135 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32
136 INT85655 Gene_expression of Crhr1 17 0.68 9.34 6.31
137 INT122680 Positive_regulation of Gene_expression of Galr2 5 0.56 2.75 6.29
138 INT72110 Gene_expression of Glp1r 48 0.78 22.46 6.17
139 INT233812 Gene_expression of PTH1R 32 0.77 18.15 6.15
140 INT21552 Regulation of Drd1a 10 0.57 3.7 6.05
141 INT52813 Regulation of Localization of CALCA 8 0.62 3.16 5.89
142 INT12564 Localization of Pthlh 23 0.81 4.37 5.82
143 INT86982 Transcription of Calca 9 0.69 2.98 5.74
144 INT1243 Regulation of ADRB2 16 0.54 1.84 5.66
145 INT89247 Transcription of Galr1 7 0.72 3.38 5.61
146 INT18366 Negative_regulation of Positive_regulation of Drd1a 6 0.42 0.49 5.54
147 INT68860 Gene_expression of Galr2 10 0.76 3.37 5.49
148 INT72000 Gene_expression of Gnaq 17 0.75 3.12 5.48
149 INT7361 Binding of Ghrh 13 0.45 1.37 5.44
150 INT5778 Regulation of Transcription of Calca 4 0.45 2.47 5.37
151 INT83014 Binding of Adora2a 13 0.48 5.57 5.33
152 INT80881 Phosphorylation of ADCY1 7 0.69 1.22 5.29
153 INT14715 Negative_regulation of Positive_regulation of CALCA 5 0.43 2.22 5.2
154 INT109246 Gene_expression of Calcrl 16 0.75 4.71 5.19
155 INT13885 Positive_regulation of Adrb2 9 0.49 1.11 5.12
156 INT9178 Regulation of Localization of Ghrh 13 0.45 2.28 5.08
157 INT27261 Regulation of Regulation of Calca 7 0.45 2.8 5.08
158 INT924 Regulation of Localization of FSHR 15 0.45 1.4 5.07
159 INT89664 Negative_regulation of Adora2a 11 0.59 7.81 5.07
160 INT19900 Binding of GHRH 22 0.37 5.75 5
161 INT37148 Negative_regulation of Gene_expression of CALCA 7 0.43 1.91 4.98
162 INT101925 Binding of Drd1a 9 0.43 1.82 4.97
163 INT923 Positive_regulation of Localization of FSHR 14 0.43 2.48 4.96
164 INT62570 Binding of Pth 48 0.48 26.45 4.85
165 INT216840 Binding of Adora2b 3 0.47 5.23 4.85
166 INT51468 Regulation of Adora2a 8 0.48 1.5 4.84
167 INT18245 Negative_regulation of Localization of Crhr1 4 0.17 0.28 4.81
168 INT7568 Negative_regulation of Crhr1 8 0.43 4.63 4.77
169 INT52251 Negative_regulation of Binding of CALCA 3 0.41 0.57 4.71
170 INT152580 Regulation of Gene_expression of Galr2 1 0.50 2.65 4.63
171 INT54987 Regulation of Gene_expression of Calca 6 0.62 3.44 4.59
172 INT19008 Positive_regulation of Positive_regulation of Ghrh 15 0.49 2.4 4.55
173 INT48567 Transcription of Drd1a 7 0.51 2.44 4.54
174 INT113078 Phosphorylation of Drd1a 4 0.30 0.77 4.45
175 INT24930 Binding of Adrb2 6 0.26 4.18 4.44
176 INT14574 Positive_regulation of Negative_regulation of ADCY1 9 0.66 2.45 4.39
177 INT89251 Positive_regulation of Transcription of Galr1 4 0.50 0.25 4.37
178 INT4097 Localization of Pth 66 0.81 47.17 4.36
179 INT98357 Binding of Gnas 11 0.41 1.87 4.35
180 INT37379 Regulation of Localization of Glp1r 10 0.62 0.16 4.32
181 INT13333 Regulation of Gene_expression of Drd1a 8 0.36 3.37 4.28
182 INT16304 Negative_regulation of Positive_regulation of GHRH 9 0.51 2.56 4.25
183 INT4104 Gene_expression of ADRB3 19 0.78 2.68 4.12
184 INT465 Binding of Adrb1 14 0.35 3.04 4.07
185 INT50228 Positive_regulation of Positive_regulation of Adora2a 8 0.39 0.1 4
186 INT142059 Regulation of Ghrh 15 0.59 3.25 3.94
187 INT484 Negative_regulation of ADRB2 13 0.59 2.85 3.94
188 INT24677 Regulation of Negative_regulation of Calca 6 0.44 0.73 3.9
189 INT119330 Binding of Calcrl 8 0.37 1.96 3.85
190 INT109 Binding of ADRB3 17 0.47 3.02 3.84
191 INT13416 Positive_regulation of Pthlh 19 0.60 14.78 3.74
192 INT63625 Gene_expression of HTR4 3 0.65 3.37 3.73
193 INT87408 Negative_regulation of ADCY2 3 0.01 0.1 3.68
194 INT101701 Regulation of Adora2a 8 0.45 2.3 3.63
195 INT111512 Negative_regulation of Galr1 4 0.59 6.45 3.61
196 INT224046 Negative_regulation of Adora2b 9 0.43 4 3.6
197 INT6882 Binding of Adrb2 5 0.47 1.97 3.55
198 INT85537 Regulation of Crhr1 4 0.45 1.64 3.53
199 INT120260 Positive_regulation of Galr2 7 0.69 2.33 3.47
200 INT62360 Positive_regulation of PTHLH 31 0.70 28.23 3.46
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