GO:0007190

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Name activation of adenylate cyclase activity
Categary Process
Go Slim No
Go Link GO:0007190
Unique Molecular Interactions 768
Total Molecular Interactions 1167
Total Single Events 14200
Pain Genes Associated 37

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of adenylate cyclase activity. They are ordered first by their pain relevance and then by number of times they were reported for activation of adenylate cyclase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69886 Ngf Positive_regulation of Calca 8 0.76 2.98 12.77
2 INT166591 Binding of CALCA and DCLK3 4 0.30 0.69 12.18
3 INT180785 Gdnf Positive_regulation of Calca 1 0.23 1.96 8.04
4 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1
5 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
6 INT69888 Ngf Positive_regulation of Localization of Calca 4 0.52 0.51 4.95
7 INT102122 Binding of Calca and RT1-M4 7 0.29 5.83 4.94
8 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
9 INT24742 Binding of Calca and Vip 1 0.37 0.18 4.68
10 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
11 INT128998 Cxcl1 Positive_regulation of Localization of Calca 1 0.66 2.96 4.15
12 INT13969 Binding of Calca and Sst 3 0.32 0.6 4.02
13 INT13966 Calca Positive_regulation of Localization of Sst 5 0.49 0.75 3.91
14 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
15 INT85541 Ngf Positive_regulation of Gene_expression of Calca 2 0.55 1.84 3.71
16 INT87491 CALCA Positive_regulation of Gene_expression of IL8 1 0.72 0.92 3.52
17 INT24710 Binding of Calca and SUB1P1 1 0.01 2.09 3.48
18 INT108473 Binding of ADCYAP1 and PNOC 1 0.32 0.64 3.41
19 INT108471 Binding of CALCA and PNOC 1 0.29 0.64 3.25
20 INT74159 Ngf Regulation of Gene_expression of Calca 2 0.60 1.66 3.22
21 INT29657 Binding of Calca and Calcb 1 0.26 0 3.16
22 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01
23 INT100835 Binding of Calca and Akap12 1 0.07 0.41 2.92
24 INT166592 Binding of CALCA and RAMP1 2 0.35 0.33 2.91
25 INT73821 CALCA Positive_regulation of Localization of IL8 1 0.25 2.37 2.91
26 INT194409 Binding of CALCA and IGKV1D-8 1 0.15 0 2.84
27 INT169134 Binding of Calca and Trpa1 1 0.37 3.37 2.79
28 INT180779 Bdnf Regulation of Calca 1 0.09 0.23 2.71
29 INT53648 Acot1 Positive_regulation of Localization of Calca 2 0.23 0 2.61
30 INT57624 Calca Regulation of Positive_regulation of Trh 1 0.50 0 2.53
31 INT48526 Binding of Calca and Penk 1 0.24 1.03 2.51
32 INT136129 Calca Positive_regulation of ATP8A2 1 0.38 0.89 2.4
33 INT284088 Binding of BDNF and NTRK2 5 0.41 3.4 2.37
34 INT13967 Calca Positive_regulation of Sst 1 0.45 0 2.3
35 INT152900 TRPV1 Regulation of Gene_expression of CALCA 1 0.69 0.73 2.29
36 INT152901 TRPV1 Regulation of Localization of CALCA 1 0.44 0.73 2.29
37 INT69887 Ngf Regulation of Calca 2 0.49 0.1 2.19
38 INT146930 CAP1 Regulation of ABCB1 1 0.29 0.3 2.19
39 INT79470 Mgat4a Regulation of Localization of Calca 1 0.08 1.72 2.1
40 INT89733 Binding of Calca and Nrm 1 0.31 0.71 2.09
41 INT63873 SRPX Positive_regulation of Localization of Calca 1 0.02 0.49 2.04
42 INT115042 Gdnf Regulation of Calca 1 0.53 0.25 2.03
43 INT26221 Calca Regulation of Gt(pU21)50Imeg 1 0.01 0 2.02
44 INT128996 Ccl2 Positive_regulation of Localization of Calca 1 0.68 1.43 2
45 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99
46 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92
47 INT24942 Calca Regulation of TAC1 1 0.13 0.7 1.89
48 INT271408 NGF Positive_regulation of Gene_expression of CALCA 1 0.09 4.89 1.88
49 INT168723 Positive_regulation of Trpv1 Positive_regulation of Gene_expression of Calca 1 0.48 1.1 1.84
50 INT163514 Ngf Positive_regulation of Gene_expression of Calca 1 0.30 2.21 1.82
51 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
52 INT24934 Calca Regulation of Nka1 3 0.05 0.43 1.73
53 INT148090 Binding of CALCA and NCOR2 1 0.00 0.65 1.71
54 INT94617 KNG1 Positive_regulation of Localization of Calca 1 0.00 0.75 1.7
55 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
56 INT56134 CALCA Positive_regulation of POMC 2 0.71 0.72 1.68
57 INT102447 Binding of CALCA and CALCRL 2 0.26 0.33 1.67
58 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
59 INT108066 Binding of NTRK1 and Ngf 3 0.33 2.56 1.66
60 INT94618 KNG1 Positive_regulation of Calca 1 0.00 0.75 1.66
61 INT144213 Nppa Positive_regulation of Localization of Calca 1 0.71 2.8 1.65
62 INT23889 Calca Positive_regulation of Localization of Tacr1 1 0.11 0.45 1.65
63 INT24157 Binding of CALCA and SFTPA1 2 0.07 0.96 1.64
64 INT103592 CAP1 Negative_regulation of Gene_expression of CPOX 1 0.19 1.52 1.64
65 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
66 INT160578 Binding of CALCA and TAC1 1 0.07 0.91 1.61
67 INT148935 Ramp1 Regulation of Calca 1 0.27 0.69 1.56
68 INT13968 Calca Negative_regulation of Positive_regulation of Sst 1 0.34 0 1.55
69 INT13970 Positive_regulation of Calca Positive_regulation of Sst 1 0.37 0 1.53
70 INT13965 Calca Positive_regulation of Positive_regulation of Sst 1 0.37 0 1.53
71 INT96784 Binding of CALCA and Calca 3 0.23 0.27 1.47
72 INT180791 Negative_regulation of Gdnf Regulation of Calca 1 0.17 0 1.47
73 INT180767 Bdnf Positive_regulation of Gene_expression of Calca 1 0.17 0 1.45
74 INT276681 Calca Regulation of Nav1 1 0.07 0.74 1.45
75 INT276686 Calca Regulation of Nav1 1 0.26 0.74 1.45
76 INT84434 Calca Negative_regulation of Negative_regulation of Hrh1 1 0.06 0.19 1.44
77 INT95325 HTR1B Negative_regulation of Calca 1 0.47 0.69 1.43
78 INT134760 Ghrl Regulation of Transcription of Calca 1 0.24 2.71 1.42
79 INT144122 Binding of Calca and P2rx6 1 0.10 0 1.4
80 INT169163 Binding of Calca and Ctbs 1 0.00 0.51 1.4
81 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39
82 INT118980 NTRK1 Positive_regulation of NGF 1 0.56 1.45 1.39
83 INT51213 Vip Regulation of Localization of Calca 1 0.38 0 1.39
84 INT8719 Npy Negative_regulation of Localization of Calca 1 0.06 0.26 1.39
85 INT168724 Creb1 Negative_regulation of Gene_expression of Calca 1 0.46 1.09 1.38
86 INT168721 Positive_regulation of Creb1 Positive_regulation of Calca 1 0.53 1.07 1.37
87 INT279165 Calca Regulation of Gene_expression of Fdft1 1 0.02 0.41 1.37
88 INT180810 Gopc Positive_regulation of Calca 1 0.02 0.28 1.36
89 INT168722 Creb1 Positive_regulation of Calca 1 0.73 1.05 1.35
90 INT261463 Binding of Drd1a and Sftpd 1 0.12 0.13 1.35
91 INT151771 Binding of P2RX3 and Calca 1 0.04 0.89 1.34
92 INT298455 Calca Positive_regulation of Gene_expression of Ceacam3 1 0.17 0.47 1.34
93 INT180786 Calca Regulation of Positive_regulation of Ngf 1 0.40 0 1.32
94 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
95 INT180764 Calca Regulation of Positive_regulation of Gdnf 1 0.21 0 1.32
96 INT180807 Calca Regulation of Sorbs1 1 0.02 0 1.32
97 INT180771 Calca Regulation of Positive_regulation of Bdnf 1 0.18 0 1.32
98 INT121096 Binding of Calca and Trpv1 3 0.37 1.23 1.29
99 INT148775 Binding of Calca and Usf1 1 0.43 0.85 1.29
100 INT194408 Regulation of Binding of CALCA and DCLK3 1 0.15 0 1.29
101 INT138210 Mzb1 Regulation of Calca 1 0.25 0.41 1.29
102 INT22501 Binding of Calca and Pth 1 0.21 0.07 1.28
103 INT88635 Ptger3 Positive_regulation of Localization of Calca 2 0.05 0 1.24
104 INT69562 Positive_regulation of AP2M1 Positive_regulation of Regulation of Adrb3 1 0.01 0.19 1.24
105 INT136249 Drd1a Positive_regulation of Phosphorylation of Tff3 1 0.01 0.18 1.23
106 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
107 INT103031 Calca Positive_regulation of Ptgs1 2 0.46 0.98 1.22
108 INT151454 Binding of Calca and Insrr 1 0.02 0.31 1.22
109 INT87586 RPL7AP5 Negative_regulation of Gene_expression of Calca 1 0.00 0.05 1.21
110 INT79471 Mgat4a Regulation of Calca 1 0.06 1.09 1.21
111 INT87585 RPL7AP5 Negative_regulation of Calca 1 0.00 0.05 1.21
112 INT124874 Gnat3 Positive_regulation of Localization of Calca 2 0.08 0.75 1.2
113 INT108067 Negative_regulation of Binding of NTRK1 and Ngf 1 0.06 2.38 1.2
114 INT116730 Rac1 Regulation of Localization of Calca 1 0.13 1.32 1.19
115 INT194403 Negative_regulation of Binding of CALCA and DCLK3 1 0.22 0 1.18
116 INT98908 Binding of NTRK1 and PKLR 1 0.41 1.95 1.18
117 INT98906 Positive_regulation of Binding of NTRK1 and PKLR 1 0.56 1.95 1.18
118 INT147446 ADCYAP1 Regulation of Localization of CP 1 0.02 1.12 1.16
119 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
120 INT338053 F2r Positive_regulation of Localization of Calca 1 0.06 0.47 1.15
121 INT147448 ADCYAP1 Regulation of Localization of NFKB1 1 0.47 1.12 1.15
122 INT91394 Negative_regulation of MMP2 Positive_regulation of CALCA 1 0.25 0.15 1.15
123 INT193288 CAP1 Positive_regulation of Pth 1 0.04 0.08 1.14
124 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
125 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
126 INT22176 Calca Regulation of Localization of Prl 4 0.69 0.39 1.11
127 INT4752 Gal Negative_regulation of Localization of Calca 1 0.41 0.06 1.11
128 INT282065 Binding of Calca and Ngf 1 0.14 0.85 1.11
129 INT74185 Cck Negative_regulation of Drd1a 1 0.30 0.1 1.1
130 INT4753 Sst Negative_regulation of Localization of Calca 1 0.39 0.06 1.1
131 INT70495 CALCA Positive_regulation of CALCB 2 0.40 0 1.08
132 INT352453 Calca Positive_regulation of Trib3 1 0.00 0.8 1.08
133 INT69889 Ngf Regulation of Localization of Calca 1 0.49 0.1 1.08
134 INT202968 Binding of MCRS1 and CAP1 1 0.03 2.46 1.08
135 INT352468 Calca Positive_regulation of Prkaca 1 0.11 0.8 1.08
136 INT91395 MMP2 Positive_regulation of CALCA 1 0.36 0.17 1.07
137 INT79372 Calca Regulation of Pnoc 1 0.34 0 1.07
138 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
139 INT139225 Calca Negative_regulation of Icam1 1 0.44 1.13 1.06
140 INT139229 Calca Negative_regulation of Cmklr1 1 0.19 1.12 1.06
141 INT139231 Calca Negative_regulation of Timp1 1 0.36 1.11 1.05
142 INT266742 GOPC Regulation of Positive_regulation of ACR 1 0.02 0.36 1.05
143 INT139226 Icam1 Negative_regulation of Calca 1 0.44 1.12 1.05
144 INT48260 Binding of Adcyap1 and Calca 1 0.35 0 1.04
145 INT130167 Trpv1 Regulation of Localization of Calca 2 0.38 0.69 1.03
146 INT86073 Med15 Regulation of Calca 1 0.49 0.2 1.03
147 INT114555 Binding of Calca and St3gal3 1 0.01 0.44 1.03
148 INT114552 Binding of Calca and Col4a4 1 0.01 0.44 1.02
149 INT51260 Calca Negative_regulation of Nts 1 0.10 0.08 1.01
150 INT51261 Calca Negative_regulation of Sst 1 0.20 0.08 1.01
151 INT7025 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.08 1.01
152 INT298298 Calca Negative_regulation of Gene_expression of Runx1 1 0.19 0.33 1
153 INT112163 Calca Positive_regulation of Mpo 1 0.49 1.23 1
154 INT298274 Gene_expression of Runx1 Negative_regulation of Calca 1 0.19 0.33 1
155 INT162299 Negative_regulation of Adarb1 Negative_regulation of Gene_expression of Calca 1 0.01 0.93 1
156 INT49163 Binding of Pax3 and Calca 1 0.03 0.37 0.98
157 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
158 INT93306 Binding of TRPV1 and CAP1 2 0.18 0.07 0.97
159 INT127672 Binding of NGFR and NTRK1 1 0.17 2.28 0.97
160 INT24395 Binding of CALCA and CLPP 1 0.03 0.17 0.96
161 INT93307 CAP1 Positive_regulation of TRPV1 1 0.15 0.07 0.96
162 INT87854 Binding of Drd1a and Positive_regulation of Localization of Abat 1 0.08 0 0.96
163 INT206857 Binding of Calca and Calcrl 4 0.37 1.9 0.95
164 INT74184 Cck Regulation of Localization of Drd1a 1 0.32 0.06 0.95
165 INT148772 Usf1 Regulation of Calca 1 0.40 0.69 0.95
166 INT180787 Calca Regulation of Gdnf 1 0.18 0.28 0.95
167 INT352447 Gse1 Negative_regulation of Gene_expression of Calca 1 0.03 0.98 0.94
168 INT24938 TAC1 Regulation of Calca 1 0.22 0.35 0.94
169 INT24939 TAC3 Regulation of Calca 1 0.01 0.35 0.94
170 INT331109 Tpnr1 Regulation of Gene_expression of Calca 1 0.06 0.97 0.94
171 INT216736 Binding of ADORA2B and ATP6V0A1 2 0.08 0.06 0.93
172 INT248186 Cxcl1 Positive_regulation of Localization of CALCA 1 0.39 0.88 0.93
173 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
174 INT127673 NGF Regulation of Gene_expression of NTRK1 1 0.48 2.12 0.92
175 INT193291 Binding of CAP1 and Cfd 1 0.02 0.13 0.91
176 INT28656 Calca Negative_regulation of Localization of Gnrhr 1 0.19 0 0.91
177 INT136172 NPY Negative_regulation of Positive_regulation of Drd1a 1 0.21 0 0.91
178 INT7292 Binding of Drd1a and Penk 1 0.14 0 0.9
179 INT52760 Oprd1 Regulation of Drd1a 1 0.02 0 0.9
180 INT52762 Dll1 Regulation of Drd1a 1 0.10 0 0.89
181 INT53155 Rac1 Positive_regulation of Gene_expression of Calca 1 0.06 0 0.89
182 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88
183 INT53153 fut10 Positive_regulation of Gene_expression of Calca 1 0.01 0 0.88
184 INT28655 Calca Negative_regulation of Localization of Gh1 1 0.34 0 0.88
185 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
186 INT213976 Calca Negative_regulation of Gene_expression of Il2 1 0.03 0.25 0.86
187 INT113542 Binding of Calca and Adarb1 2 0.00 0.44 0.85
188 INT120825 Adcyap1 Positive_regulation of Localization of Nos1 1 0.26 0.62 0.85
189 INT351323 Nts Regulation of Localization of Calca 1 0.01 0.6 0.85
190 INT42865 Binding of Adrb2 and Man2a2 1 0.23 1.03 0.85
191 INT42864 Regulation of Binding of Adrb2 and Man2a2 1 0.28 1.03 0.85
192 INT338695 CAP1 Regulation of Trpv1 1 0.01 0.14 0.85
193 INT128702 Ednra Regulation of EDNRA 1 0.00 0.58 0.84
194 INT29279 Binding of Drd1a and Htr1a 1 0.35 0.2 0.84
195 INT28654 Calca Regulation of Localization of Gh1 1 0.36 0 0.84
196 INT344101 Positive_regulation of Drd1a Positive_regulation of Localization of Abat 1 0.01 0 0.84
197 INT342991 HCL1 Positive_regulation of CALCA 1 0.03 0.71 0.84
198 INT111363 TRPV1 Positive_regulation of Localization of Calca 1 0.11 0 0.83
199 INT225691 TRPV1 Positive_regulation of Localization of CALCA 1 0.18 0.7 0.83
200 INT87490 CALCA Positive_regulation of Gene_expression of CCL5 1 0.30 0.14 0.81

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of adenylate cyclase activity. They are ordered first by their pain relevance and then by number of times they were reported in activation of adenylate cyclase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 2008 0.81 518.3 1408.65
2 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84
3 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08
4 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04
5 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38
6 INT2649 Regulation of Calca 433 0.62 146.05 330.95
7 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45
8 INT626 Localization of CALCA 289 0.81 125.39 221.15
9 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57
10 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2
11 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47
12 INT2541 Binding of Calca 200 0.48 67.14 134.62
13 INT5008 Localization of Calca 204 0.81 80.35 125.16
14 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75
15 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61
16 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03
17 INT6761 Binding of CALCA 100 0.48 26.71 62.05
18 INT4760 Negative_regulation of Gene_expression of Calca 93 0.59 34.19 60.3
19 INT4241 Regulation of CALCA 87 0.62 28.19 55.29
20 INT4891 Transcription of Calca 81 0.72 35.27 53.75
21 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66
22 INT97674 Positive_regulation of Localization of Calca 70 0.69 27.71 51.79
23 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
24 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34
25 INT117598 Regulation of ACR 118 0.26 41.25 48.01
26 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8
27 INT28265 Positive_regulation of Calca 62 0.70 29.1 41.17
28 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48
29 INT8784 Negative_regulation of Positive_regulation of Calca 40 0.59 14.67 33.49
30 INT8746 Negative_regulation of Calca 50 0.59 21.22 33.45
31 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76
32 INT22499 Regulation of Calca 42 0.62 17.32 28.02
33 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
34 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43
35 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42
36 INT106720 Positive_regulation of Adcy1 30 0.50 22.05 22.68
37 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24
38 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51
39 INT7680 Regulation of Drd1a 27 0.45 4.52 18.86
40 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51
41 INT7020 Negative_regulation of Drd1a 25 0.57 1.84 17.1
42 INT35998 Positive_regulation of Gene_expression of Calca 31 0.70 16.16 16.98
43 INT6150 Positive_regulation of Negative_regulation of Calca 20 0.68 4.06 16.26
44 INT5859 Positive_regulation of Positive_regulation of Drd1a 20 0.55 2.05 15.61
45 INT216751 Gene_expression of ADORA2B 36 0.60 3.42 15.6
46 INT663 Negative_regulation of Adrb3 55 0.59 15.95 14.68
47 INT110 Regulation of Adrb3 33 0.60 8.09 13.84
48 INT130424 Negative_regulation of Adcy1 19 0.58 16.31 13.6
49 INT65965 Gene_expression of Adcyap1 52 0.78 22.53 13.14
50 INT65109 Negative_regulation of Transcription of Calca 16 0.59 8.63 12.84
51 INT195226 Positive_regulation of ACR 23 0.26 7.85 12.62
52 INT26217 Binding of Calca 22 0.48 5.22 12.57
53 INT11244 Transcription of CALCA 21 0.69 3.61 12.27
54 INT15136 Regulation of Positive_regulation of Calca 12 0.62 3.02 12.16
55 INT7682 Binding of Drd1a 22 0.48 1.8 11.83
56 INT6151 Negative_regulation of Negative_regulation of Calca 14 0.58 4.86 11.81
57 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79
58 INT5779 Positive_regulation of Transcription of Calca 15 0.62 5.61 10.86
59 INT101203 Negative_regulation of Gene_expression of Calca 12 0.59 7.06 10.72
60 INT8188 Positive_regulation of Adrb3 27 0.68 7.32 10.44
61 INT147452 Gene_expression of ADCYAP1 14 0.77 12.54 9.28
62 INT106199 Positive_regulation of Adcyap1 32 0.68 13.68 9.14
63 INT93309 Positive_regulation of CAP1 17 0.43 11.4 9.13
64 INT103251 Negative_regulation of Localization of Calca 13 0.43 9.36 8.86
65 INT29411 Positive_regulation of ADRB2 13 0.65 5.42 8.78
66 INT93310 Gene_expression of CAP1 14 0.58 3.07 8.55
67 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42
68 INT106719 Gene_expression of Adcy1 18 0.77 12.18 8.42
69 INT16735 Localization of Drd1a 11 0.61 0.35 8.42
70 INT8761 Negative_regulation of Binding of Calca 12 0.43 3.59 8.32
71 INT54978 Binding of EDNRA 36 0.41 14.97 7.86
72 INT48314 Gene_expression of NTRK2 17 0.75 7.84 7.83
73 INT11568 Gene_expression of ADORA2A 14 0.73 1.51 7.79
74 INT298 Negative_regulation of ADRB3 23 0.59 6.82 7.56
75 INT65964 Regulation of Adcyap1 13 0.45 10.1 7.54
76 INT7883 Binding of ADRB2 18 0.47 5.49 7.37
77 INT216752 Binding of ADORA2B 17 0.36 0.76 7.36
78 INT25220 Positive_regulation of Binding of Calca 7 0.69 3.78 7.34
79 INT124264 Regulation of Localization of Calca 10 0.33 1.39 7.14
80 INT22369 Negative_regulation of Drd1a 15 0.47 6.13 6.87
81 INT71151 Regulation of NTRK1 10 0.62 6.65 6.21
82 INT48313 Binding of NTRK1 19 0.47 14.44 6.12
83 INT21552 Regulation of Drd1a 10 0.57 3.7 6.05
84 INT52813 Regulation of Localization of CALCA 8 0.62 3.16 5.89
85 INT86982 Transcription of Calca 9 0.69 2.98 5.74
86 INT1243 Regulation of ADRB2 16 0.54 1.84 5.66
87 INT18366 Negative_regulation of Positive_regulation of Drd1a 6 0.42 0.49 5.54
88 INT71152 Negative_regulation of NTRK1 15 0.59 10.28 5.5
89 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49
90 INT5778 Regulation of Transcription of Calca 4 0.45 2.47 5.37
91 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36
92 INT266746 Binding of ACR 8 0.23 3.44 5.26
93 INT14715 Negative_regulation of Positive_regulation of CALCA 5 0.43 2.22 5.2
94 INT13885 Positive_regulation of Adrb2 9 0.49 1.11 5.12
95 INT27261 Regulation of Regulation of Calca 7 0.45 2.8 5.08
96 INT37148 Negative_regulation of Gene_expression of CALCA 7 0.43 1.91 4.98
97 INT101925 Binding of Drd1a 9 0.43 1.82 4.97
98 INT52251 Negative_regulation of Binding of CALCA 3 0.41 0.57 4.71
99 INT54987 Regulation of Gene_expression of Calca 6 0.62 3.44 4.59
100 INT48567 Transcription of Drd1a 7 0.51 2.44 4.54
101 INT113078 Phosphorylation of Drd1a 4 0.30 0.77 4.45
102 INT24930 Binding of Adrb2 6 0.26 4.18 4.44
103 INT106548 Localization of Adcyap1 14 0.80 5.05 4.33
104 INT13333 Regulation of Gene_expression of Drd1a 8 0.36 3.37 4.28
105 INT106721 Regulation of Adcy1 6 0.45 2.32 4.17
106 INT4104 Gene_expression of ADRB3 19 0.78 2.68 4.12
107 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03
108 INT484 Negative_regulation of ADRB2 13 0.59 2.85 3.94
109 INT24677 Regulation of Negative_regulation of Calca 6 0.44 0.73 3.9
110 INT109 Binding of ADRB3 17 0.47 3.02 3.84
111 INT115877 Negative_regulation of Adcyap1 14 0.59 5.31 3.74
112 INT81188 Gene_expression of Vipr2 16 0.78 4.38 3.7
113 INT6882 Binding of Adrb2 5 0.47 1.97 3.55
114 INT193281 Binding of CAP1 7 0.07 4.57 3.53
115 INT16626 Positive_regulation of Adrb2 10 0.30 2.41 3.4
116 INT62901 Positive_regulation of Gene_expression of Drd1a 2 0.57 0.66 3.35
117 INT128138 Positive_regulation of Positive_regulation of Adcy1 5 0.45 2.67 3.25
118 INT120823 Positive_regulation of Gene_expression of Adcyap1 10 0.68 6.71 3.22
119 INT13335 Negative_regulation of Gene_expression of Drd1a 6 0.34 0.8 3.16
120 INT51151 Positive_regulation of Regulation of Calca 8 0.50 1.77 3.08
121 INT27100 Binding of Adrb3 10 0.47 3.44 3.07
122 INT18365 Positive_regulation of Regulation of Drd1a 4 0.50 1.74 3.04
123 INT211192 Localization of ACR 8 0.73 3.04 3.03
124 INT93109 Phosphorylation of NTRK1 5 0.80 3.22 2.99
125 INT41474 Gene_expression of ADRB2 10 0.75 1.56 2.94
126 INT27146 Negative_regulation of Regulation of Calca 4 0.43 1.18 2.9
127 INT266745 Regulation of Gene_expression of ACR 6 0.10 1.53 2.87
128 INT113077 Positive_regulation of Phosphorylation of Drd1a 1 0.11 0.15 2.87
129 INT38204 Gene_expression of Acr 4 0.66 4.23 2.85
130 INT60672 Regulation of Gene_expression of CALCA 3 0.61 1.76 2.85
131 INT95720 Phosphorylation of Calca 2 0.80 2.04 2.8
132 INT57354 Positive_regulation of Positive_regulation of Calca 3 0.60 1.42 2.78
133 INT33480 Gene_expression of Adrb2 4 0.66 1.96 2.77
134 INT8840 Positive_regulation of Positive_regulation of CALCA 8 0.50 1.8 2.74
135 INT258590 Gene_expression of ADORA3 8 0.36 0.17 2.67
136 INT119518 Positive_regulation of Gene_expression of NTRK1 5 0.67 3.47 2.66
137 INT64248 Positive_regulation of Positive_regulation of Drd1a 6 0.45 1.97 2.62
138 INT132685 Negative_regulation of NTRK2 4 0.42 2.89 2.58
139 INT146931 Regulation of CAP1 1 0.44 0.22 2.58
140 INT77213 Transcription of ADORA2A 1 0.69 0 2.55
141 INT89992 Positive_regulation of Gene_expression of Drd1a 5 0.39 2.11 2.54
142 INT19292 Protein_catabolism of CALCA 7 0.76 0.8 2.53
143 INT59119 Positive_regulation of ADCYAP1 9 0.69 4.68 2.48
144 INT95799 Binding of NTRK2 8 0.35 2.95 2.47
145 INT514 Gene_expression of Adrb2 3 0.53 0.23 2.46
146 INT18202 Localization of Adrb3 7 0.80 2.76 2.44
147 INT194586 Negative_regulation of ACR 8 0.26 2.04 2.41
148 INT86462 Transcription of Drd1a 3 0.44 1.86 2.36
149 INT97485 Localization of ADCYAP1 4 0.78 0.24 2.35
150 INT25666 Negative_regulation of ADRB1 11 0.44 3.12 2.33
151 INT9764 Gene_expression of Adrb3 10 0.62 4.14 2.33
152 INT3531 Regulation of Adrb2 7 0.44 1.48 2.25
153 INT30372 Regulation of ADRB3 8 0.60 0.57 2.24
154 INT258404 Positive_regulation of Gene_expression of ACR 4 0.28 1.08 2.24
155 INT24407 Negative_regulation of Binding of Drd1a 3 0.25 0.81 2.18
156 INT34500 Positive_regulation of ADRB3 12 0.58 2.59 2.16
157 INT103298 Binding of CALCR 5 0.47 6.03 2.15
158 INT70725 Negative_regulation of Binding of ADRB2 3 0.57 0.4 2.14
159 INT147453 Positive_regulation of Gene_expression of ADCYAP1 3 0.69 3.49 2.1
160 INT58752 Positive_regulation of Binding of CALCA 3 0.49 0.73 2.09
161 INT179311 Transcription of GNAS 2 0.10 0.67 2.08
162 INT152902 Positive_regulation of Transcription of CALCA 5 0.66 0.99 2.07
163 INT21046 Regulation of Positive_regulation of Drd1a 3 0.44 0.09 2.06
164 INT108903 Negative_regulation of GNAS 7 0.57 1.58 2.04
165 INT147451 Regulation of Gene_expression of ADCYAP1 3 0.61 1.88 2.04
166 INT190783 Binding of Adcy1 3 0.35 1.35 2.03
167 INT54986 Negative_regulation of Positive_regulation of Calca 2 0.43 0.93 2.02
168 INT13837 Negative_regulation of Positive_regulation of Drd1a 2 0.43 1.43 2.01
169 INT66941 Localization of NTRK1 8 0.78 5.89 1.96
170 INT245945 Localization of CAP1 4 0.69 1.63 1.95
171 INT24291 Positive_regulation of Negative_regulation of CALCA 3 0.61 0.67 1.91
172 INT40832 Localization of ADRB2 5 0.73 2.21 1.81
173 INT216749 Positive_regulation of ADORA2B 6 0.37 0.89 1.72
174 INT76198 Positive_regulation of ADORA3 3 0.45 1.53 1.7
175 INT77415 Localization of GLP1R 23 0.63 11.1 1.69
176 INT289739 Positive_regulation of Adcy3 3 0.28 0.64 1.63
177 INT305029 Localization of Adcy1 2 0.70 5.94 1.63
178 INT241566 Negative_regulation of Negative_regulation of Calca 1 0.03 0.72 1.63
179 INT89467 Gene_expression of Lhcgr 9 0.36 1.59 1.62
180 INT299751 Positive_regulation of Positive_regulation of ACR 1 0.05 0.78 1.59
181 INT193284 Positive_regulation of Gene_expression of CAP1 1 0.07 0.05 1.55
182 INT216847 Transcription of ADORA2B 1 0.51 0.93 1.55
183 INT43482 Regulation of Binding of ADRB3 4 0.60 1.06 1.54
184 INT242212 Gene_expression of GLP1R 29 0.65 11.36 1.52
185 INT85046 Positive_regulation of Positive_regulation of NTRK1 2 0.50 0.63 1.51
186 INT29667 Positive_regulation of CRHR1 6 0.54 1.09 1.5
187 INT48300 Regulation of Binding of Calca 2 0.39 0.73 1.49
188 INT23938 Positive_regulation of Gene_expression of EDNRA 8 0.45 9.82 1.47
189 INT121347 Binding of GNAS 8 0.13 3.99 1.47
190 INT140305 Negative_regulation of Binding of Drd1a 2 0.21 0.54 1.46
191 INT129488 Regulation of Gene_expression of EDNRA 5 0.51 3.39 1.44
192 INT113079 Regulation of Phosphorylation of Drd1a 1 0.06 0.07 1.43
193 INT52250 Positive_regulation of Regulation of CALCA 1 0.48 0.08 1.43
194 INT336571 Gene_expression of DRD5 1 0.06 0.73 1.41
195 INT162308 Phosphorylation of GNAS 3 0.01 1.71 1.4
196 INT5466 Positive_regulation of Negative_regulation of ADRB3 2 0.44 0.17 1.39
197 INT108603 Positive_regulation of NTRK2 3 0.49 1.3 1.38
198 INT78363 Negative_regulation of Adrb3 2 0.19 3.32 1.38
199 INT78097 Negative_regulation of Regulation of CALCA 2 0.42 2.02 1.37
200 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32
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