GO:0007191

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Name activation of adenylate cyclase activity by dopamine receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0007191
Unique Molecular Interactions 813
Total Molecular Interactions 1122
Total Single Events 10135
Pain Genes Associated 18

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of adenylate cyclase activity by dopamine receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for activation of adenylate cyclase activity by dopamine receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
3 INT21276 Binding of Oprd1 and Penk 9 0.54 1.14 8.28
4 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
5 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
6 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
7 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 0.30 0.91 4.18
8 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
9 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
10 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
11 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
12 INT249566 Binding of Oprd1 and Psmd1 1 0.01 0.82 3.8
13 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
14 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
15 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
16 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
17 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
18 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
19 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
20 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
21 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
22 INT137230 Trh Regulation of Gene_expression of Oprd1 1 0.01 1.62 2.75
23 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
24 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
25 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
26 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
27 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59
28 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
29 INT69665 Binding of Oprd1 and Pnoc 5 0.35 0.4 2.5
30 INT249567 Positive_regulation of Binding of Oprd1 and Psmd1 1 0.01 0.66 2.5
31 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
32 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
33 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
34 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
35 INT5486 Oprd1 Regulation of Cck 1 0.21 0 2.16
36 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
37 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
38 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
39 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
40 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07
41 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
42 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
43 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
44 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
45 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
46 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
47 INT68272 Binding of Oprd1 and G2e3 1 0.00 0.11 1.93
48 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
49 INT65025 Binding of Oprm1 and Hps4 1 0.01 0 1.93
50 INT169498 Binding of Oprm1 and Mirlet7a-1 1 0.32 0 1.9
51 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
52 INT153582 Binding of Oprm1 and Hint1 1 0.01 0 1.87
53 INT211747 Negative_regulation of Binding of Oprm1 and Mors1 1 0.09 0 1.86
54 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85
55 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
56 INT119917 Zfp821 Positive_regulation of Positive_regulation of Oprd1 1 0.01 0 1.82
57 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
58 INT169502 Mirlet7a-1 Regulation of Oprm1 1 0.53 0 1.81
59 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
60 INT70225 oh Regulation of Oprd1 1 0.20 0.13 1.8
61 INT168925 Binding of Oprm1 and Imraq2 1 0.04 0.13 1.78
62 INT168924 Positive_regulation of Binding of Oprm1 and Imraq2 1 0.06 0.13 1.78
63 INT211746 Binding of Oprm1 and Mors1 1 0.08 0 1.78
64 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
65 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
66 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
67 INT129953 Oprd1 Regulation of Cspg5 1 0.17 0.15 1.74
68 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
69 INT37840 Binding of Cyp27b1 and Oprd1 1 0.01 0 1.73
70 INT6407 Binding of Lama5 and Oprm1 1 0.02 0.08 1.72
71 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
72 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
73 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
74 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
75 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
76 INT103725 Negative_regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.17 0.38 1.65
77 INT315180 Gene_expression of Mors1 Positive_regulation of Gene_expression of Oprm1 1 0.03 0.48 1.64
78 INT134742 Binding of OPRM1 and SV2A 1 0.33 0.18 1.64
79 INT103726 Regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.10 0.38 1.64
80 INT61049 Binding of Oprd1 and Negative_regulation of Gene_expression of Odc1 1 0.21 0 1.64
81 INT315181 Gene_expression of Mors1 Positive_regulation of Oprm1 1 0.03 0.48 1.64
82 INT90046 Oprm1 Positive_regulation of P9Ehs1 2 0.16 0.92 1.63
83 INT199501 Pdyn Positive_regulation of Oprm1 1 0.01 0.86 1.63
84 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
85 INT61674 Gpm6a Regulation of Oprd1 1 0.01 0.07 1.62
86 INT109525 Binding of DMRT1 and Oprm1 1 0.08 0 1.62
87 INT140341 Ngf Positive_regulation of Gene_expression of Oprm1 1 0.02 0.33 1.59
88 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
89 INT317558 Binding of Oprm1 and Rgs17 1 0.18 0 1.59
90 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
91 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
92 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
93 INT148821 Binding of Oprm1 and Grin1 1 0.05 0.24 1.55
94 INT148820 Binding of Oprm1 and Naa15 1 0.02 0.24 1.55
95 INT8734 Pebp1 Positive_regulation of Oprd1 1 0.01 0 1.54
96 INT111828 UPB1 Positive_regulation of Oprm1 1 0.00 0.85 1.53
97 INT72666 Binding of ODT and Oprm1 1 0.03 0.53 1.5
98 INT117008 Sfpi1 Regulation of Oprm1 1 0.56 0.56 1.49
99 INT8735 Oprm1 Positive_regulation of Scn4a 1 0.00 0 1.49
100 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47
101 INT317509 Oprm1 Negative_regulation of Phosphorylation of Oprd1 1 0.00 0 1.46
102 INT141673 Oprm1 Positive_regulation of Negative_regulation of Ltp 1 0.13 0 1.46
103 INT141676 OPRM1 Positive_regulation of Ltp 1 0.04 0 1.46
104 INT141674 Oprm1 Positive_regulation of Ltp 1 0.13 0 1.46
105 INT141675 OPRM1 Positive_regulation of Negative_regulation of Ltp 1 0.04 0 1.46
106 INT131039 Binding of Oprm1 and Prf1 1 0.17 0 1.45
107 INT131041 Negative_regulation of Binding of Oprm1 and Prf1 1 0.21 0 1.45
108 INT131040 Binding of Oprm1 and S100a9 1 0.24 0 1.45
109 INT161858 OPRM1 Positive_regulation of GRIN1 1 0.50 0.12 1.45
110 INT153581 Binding of Oprm1 and Prkcg 1 0.00 0 1.44
111 INT69337 Oprm1 Positive_regulation of Atxn2l 1 0.01 0.27 1.43
112 INT128915 PENK Regulation of Gene_expression of OPRM1 1 0.22 0.07 1.43
113 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43
114 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41
115 INT329451 Binding of Oprd1 and Tacr1 1 0.05 0.23 1.41
116 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41
117 INT142852 Oprm1 Positive_regulation of Oprd1 1 0.41 0.06 1.41
118 INT329452 Binding of Tac1 and Oprd1 1 0.01 0.23 1.4
119 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
120 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 0.03 0 1.39
121 INT6466 Binding of Npr1 and Oprd1 1 0.01 0 1.37
122 INT51203 Binding of OPRK1 and OPRM1 2 0.29 0.3 1.36
123 INT160590 CSF2 Positive_regulation of Gene_expression of OPRM1 1 0.16 0.54 1.35
124 INT139987 Oprm1 Positive_regulation of Localization of Oprl1 1 0.16 0.17 1.35
125 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
126 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
127 INT160587 IFNG Positive_regulation of Gene_expression of OPRM1 1 0.18 0.54 1.35
128 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
129 INT160589 IL4 Positive_regulation of Gene_expression of OPRM1 1 0.13 0.54 1.35
130 INT261463 Binding of Drd1a and Sftpd 1 0.12 0.13 1.35
131 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
132 INT249565 Binding of Gabrg1 and Oprd1 1 0.00 0.1 1.33
133 INT13756 Binding of Oprd1 and Scn4a 1 0.02 0 1.32
134 INT13755 Binding of Oprd1 and Ap2m1 1 0.20 0 1.32
135 INT51200 Binding of OPRM1 and PENK 2 0.17 0.23 1.31
136 INT38624 Binding of Oprm1 and Insrr 2 0.01 0.24 1.31
137 INT317519 Grin1 Positive_regulation of Negative_regulation of Oprm1 1 0.14 0 1.31
138 INT130786 Positive_regulation of Oprm1 Positive_regulation of Arc 1 0.27 0.9 1.31
139 INT168229 Oprm1 Regulation of Cea 1 0.10 0.26 1.3
140 INT57263 Binding of Oprd1 and Atxn2l 1 0.02 0 1.29
141 INT128310 Oprm1 Positive_regulation of Oprm1 1 0.00 0.1 1.29
142 INT57262 Binding of Gria4 and Oprd1 1 0.06 0 1.29
143 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
144 INT89943 Binding of Oprm1 and Il2 1 0.03 0.53 1.28
145 INT114929 Positive_regulation of Binding of Oprm1 and Crebbp 1 0.06 0.14 1.28
146 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
147 INT64749 Negative_regulation of Binding of Oprm1 and Pck1 1 0.47 0.21 1.27
148 INT114925 Binding of Oprm1 and Crebbp 1 0.06 0.14 1.27
149 INT34393 Oprd1 Negative_regulation of Adcy1 1 0.36 0 1.27
150 INT124767 Creb1 Regulation of Oprm1 1 0.45 0 1.26
151 INT207548 U Negative_regulation of Gene_expression of Oprm1 1 0.01 0.46 1.26
152 INT121464 Negative_regulation of Oprm1 Positive_regulation of Dnm2 1 0.34 0 1.26
153 INT110542 SIGMAR1 Regulation of OPRM1 1 0.04 0.33 1.25
154 INT110543 SIGMAR1 Regulation of Gene_expression of OPRM1 1 0.04 0.33 1.25
155 INT87375 Binding of Gabrg1 and Oprm1 1 0.00 0.83 1.25
156 INT126801 Regulation of Binding of Oprm1 and Penk 1 0.34 0.4 1.25
157 INT151444 Binding of Oprm1 and Pag1 1 0.00 1.5 1.24
158 INT121465 Binding of Dnm2 and Oprm1 1 0.23 0 1.24
159 INT167278 Binding of OPRM1 and REST 1 0.08 0.94 1.24
160 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24
161 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
162 INT63864 Oprd1 Regulation of Localization of Prl 2 0.16 0 1.23
163 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 0.02 0 1.23
164 INT136249 Drd1a Positive_regulation of Phosphorylation of Tff3 1 0.01 0.18 1.23
165 INT58140 Binding of AP2M1 and Oprm1 1 0.01 0.4 1.23
166 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
167 INT76165 IGKV2-30 Positive_regulation of Phosphorylation of Oprm1 1 0.00 0.08 1.22
168 INT75229 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.44 0 1.22
169 INT76163 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.02 0.08 1.22
170 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
171 INT124157 Oprm1 Negative_regulation of Gnb5 1 0.25 0.4 1.19
172 INT133496 Binding of Oprm1 and Cckbr 1 0.15 0 1.19
173 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
174 INT13203 Oprd1 Negative_regulation of Akr1d1 1 0.01 0 1.18
175 INT49956 OPRM1 Positive_regulation of SGCG 1 0.53 0.3 1.18
176 INT153589 Binding of PRKCI and Oprm1 1 0.06 0 1.17
177 INT153588 Binding of HINT1 and Oprm1 1 0.06 0 1.17
178 INT13205 Oprd1 Negative_regulation of Npr1 2 0.01 0 1.16
179 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
180 INT200312 Rest Regulation of Oprm1 1 0.23 0.27 1.16
181 INT137144 ITIH4 Regulation of OPRM1 1 0.20 1.13 1.16
182 INT125696 Binding of OPRM1 and SNRNP70 1 0.06 0.99 1.15
183 INT326665 Cpe Positive_regulation of Oprd1 1 0.01 1.24 1.15
184 INT199493 Ngf Regulation of Oprd1 1 0.05 1.05 1.15
185 INT88778 Binding of Oprm1 and Pomc 3 0.21 0.56 1.14
186 INT317549 Negative_regulation of Camk2a Negative_regulation of Phosphorylation of Oprm1 1 0.19 0 1.14
187 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
188 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
189 INT110522 Oprm1 Positive_regulation of Oprk1 1 0.11 0 1.12
190 INT221183 Binding of OPRM1 and Mors1 1 0.00 0 1.12
191 INT21267 Cck Negative_regulation of Binding of Oprd1 1 0.50 0 1.12
192 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
193 INT69338 Binding of Oprd1 and Oprm1 1 0.24 0.26 1.11
194 INT113540 Binding of OPRM1 and Tac1 1 0.04 0.1 1.1
195 INT133497 Binding of Oprm1 and Cckbr 1 0.03 0 1.1
196 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
197 INT127133 Positive_regulation of OPRM1 Positive_regulation of Protein_catabolism of SUCLG2 1 0.20 0.2 1.1
198 INT74185 Cck Negative_regulation of Drd1a 1 0.30 0.1 1.1
199 INT60783 Binding of Oprd1 and Cck 1 0.26 0.47 1.09
200 INT142413 Oprm1 Positive_regulation of Gdnf 1 0.19 0.29 1.09

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of adenylate cyclase activity by dopamine receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in activation of adenylate cyclase activity by dopamine receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
2 INT5660 Binding of Oprd1 477 0.48 71.86 342.06
3 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32
4 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
5 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41
6 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
7 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9
8 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
9 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61
10 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
11 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
12 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93
13 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11
14 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
15 INT6042 Binding of Oprm1 248 0.48 31.77 154.34
16 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
17 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93
18 INT12569 Localization of Oprd1 94 0.81 23.81 104.56
19 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
20 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
21 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
22 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
23 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
24 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
25 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54
26 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78
27 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
28 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12
29 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
30 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
31 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
32 INT7828 Positive_regulation of Oprd1 55 0.69 14.11 42.86
33 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
34 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58
35 INT14137 Localization of Oprm1 56 0.81 2.88 36.09
36 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
37 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29
38 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52
39 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95
40 INT12397 Gene_expression of Oprd1 53 0.78 9.1 31.31
41 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
42 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66
43 INT15000 Transcription of Oprd1 32 0.72 5.7 29.22
44 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
45 INT5771 Binding of Oprd1 37 0.48 2.6 27.54
46 INT72677 Regulation of Gene_expression of Oprm1 45 0.62 13.95 26.75
47 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48
48 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52
49 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43
50 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42
51 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79
52 INT57253 Negative_regulation of Binding of Oprm1 24 0.43 5.27 22.67
53 INT31393 Positive_regulation of Localization of Oprd1 10 0.66 7.32 21.23
54 INT27529 Phosphorylation of Oprd1 23 0.47 1.16 20.18
55 INT49835 Negative_regulation of Positive_regulation of Oprm1 21 0.42 4.11 20.11
56 INT21105 Phosphorylation of Oprm1 32 0.82 0.83 19.29
57 INT7680 Regulation of Drd1a 27 0.45 4.52 18.86
58 INT31905 Positive_regulation of Binding of Oprd1 21 0.66 3.31 18.44
59 INT58495 Positive_regulation of Positive_regulation of Oprm1 22 0.49 2.44 17.66
60 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51
61 INT7020 Negative_regulation of Drd1a 25 0.57 1.84 17.1
62 INT6043 Negative_regulation of Binding of Oprm1 24 0.57 2.67 16.78
63 INT32753 Positive_regulation of Positive_regulation of OPRM1 19 0.62 3.3 16.73
64 INT6066 Negative_regulation of Positive_regulation of Oprd1 15 0.43 1.36 16.63
65 INT33915 Regulation of Positive_regulation of Oprm1 22 0.60 2.44 16.43
66 INT5859 Positive_regulation of Positive_regulation of Drd1a 20 0.55 2.05 15.61
67 INT68811 Regulation of Transcription of Oprm1 19 0.61 3.67 15.15
68 INT12658 Regulation of Binding of Oprm1 9 0.57 2.44 14.95
69 INT29352 Negative_regulation of Oprd1 16 0.58 6.51 14.6
70 INT54284 Negative_regulation of Gene_expression of Oprd1 16 0.42 4.56 14.34
71 INT76863 Negative_regulation of Gene_expression of OPRM1 21 0.57 6.56 13.69
72 INT80883 Positive_regulation of Phosphorylation of OPRM1 13 0.69 1.03 13.65
73 INT68814 Positive_regulation of Transcription of Oprm1 16 0.60 2.72 13.57
74 INT62523 Positive_regulation of Phosphorylation of Oprm1 11 0.53 0.75 12.51
75 INT7682 Binding of Drd1a 22 0.48 1.8 11.83
76 INT6044 Regulation of Binding of Oprm1 16 0.61 3.01 11.11
77 INT59766 Positive_regulation of Negative_regulation of Oprm1 9 0.50 1.31 11.08
78 INT71592 Negative_regulation of Gene_expression of Oprm1 11 0.58 4.03 10.37
79 INT75955 Gene_expression of Drd3 19 0.77 4.39 10.07
80 INT62919 Regulation of Gnas 22 0.43 5.61 9.55
81 INT49483 Regulation of Positive_regulation of Oprm1 8 0.61 2.34 9.4
82 INT20835 Negative_regulation of Negative_regulation of Oprm1 10 0.43 0.56 8.96
83 INT33209 Positive_regulation of Binding of OPRM1 8 0.68 0.63 8.95
84 INT76162 Positive_regulation of Phosphorylation of Oprm1 11 0.69 0.64 8.72
85 INT98835 Positive_regulation of Transcription of Oprm1 15 0.65 2.47 8.67
86 INT16735 Localization of Drd1a 11 0.61 0.35 8.42
87 INT18021 Positive_regulation of Binding of Oprm1 16 0.70 2.53 8.38
88 INT31394 Negative_regulation of Localization of Oprd1 3 0.39 2.38 7.89
89 INT91238 Regulation of Negative_regulation of Oprm1 6 0.45 1.4 7.85
90 INT31060 Negative_regulation of Binding of OPRM1 12 0.37 2.65 7.75
91 INT101721 Positive_regulation of Transcription of OPRM1 8 0.48 1.22 7.74
92 INT62372 Positive_regulation of Localization of Oprm1 8 0.50 0.46 7.71
93 INT121815 Regulation of Positive_regulation of OPRM1 7 0.62 0.75 7.36
94 INT20845 Positive_regulation of Negative_regulation of Oprd1 7 0.70 1.81 7.33
95 INT6239 Regulation of Regulation of Oprd1 7 0.45 0.34 7.26
96 INT5311 Regulation of Negative_regulation of Oprd1 11 0.43 0.99 7.23
97 INT16628 Negative_regulation of Positive_regulation of Oprm1 9 0.43 0.89 6.92
98 INT62524 Negative_regulation of Phosphorylation of Oprm1 7 0.59 0.08 6.92
99 INT75228 Positive_regulation of Negative_regulation of Oprm1 8 0.49 0.95 6.9
100 INT22369 Negative_regulation of Drd1a 15 0.47 6.13 6.87
101 INT64215 Gene_expression of Drd3 16 0.78 5.27 6.71
102 INT54062 Transcription of Oprd1 11 0.68 1.05 6.65
103 INT5932 Regulation of Regulation of Oprm1 7 0.61 0.44 6.47
104 INT42832 Negative_regulation of Positive_regulation of OPRM1 6 0.36 0.96 6.35
105 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33
106 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32
107 INT97600 Regulation of Transcription of OPRM1 8 0.52 1.14 6.21
108 INT53135 Positive_regulation of Localization of Oprm1 2 0.50 0 6.12
109 INT91575 Positive_regulation of Phosphorylation of Oprd1 8 0.02 0.23 6.07
110 INT21552 Regulation of Drd1a 10 0.57 3.7 6.05
111 INT27118 Regulation of Binding of OPRM1 10 0.62 1.18 5.97
112 INT42799 Positive_regulation of Drd3 11 0.69 1.1 5.92
113 INT26555 Regulation of Positive_regulation of Oprd1 6 0.59 2.47 5.76
114 INT110545 Regulation of Regulation of OPRM1 7 0.42 1.68 5.67
115 INT112927 Negative_regulation of Localization of Oprm1 4 0.39 0.31 5.59
116 INT18366 Negative_regulation of Positive_regulation of Drd1a 6 0.42 0.49 5.54
117 INT32979 Positive_regulation of Localization of OPRM1 5 0.50 0 5.54
118 INT50330 Positive_regulation of Drd3 7 0.70 0.76 5.08
119 INT101925 Binding of Drd1a 9 0.43 1.82 4.97
120 INT42833 Positive_regulation of Negative_regulation of OPRM1 6 0.48 0.12 4.95
121 INT24011 Binding of Drd3 13 0.47 3.03 4.64
122 INT48567 Transcription of Drd1a 7 0.51 2.44 4.54
123 INT113078 Phosphorylation of Drd1a 4 0.30 0.77 4.45
124 INT98357 Binding of Gnas 11 0.41 1.87 4.35
125 INT23738 Regulation of Transcription of Oprd1 6 0.26 0.48 4.3
126 INT13333 Regulation of Gene_expression of Drd1a 8 0.36 3.37 4.28
127 INT76714 Binding of Drd3 9 0.37 2.33 4.09
128 INT105998 Protein_catabolism of Oprm1 5 0.95 0.88 4.08
129 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03
130 INT29671 Regulation of Localization of Oprd1 4 0.24 1.04 3.92
131 INT65460 Positive_regulation of Gene_expression of Oprd1 8 0.69 1.87 3.87
132 INT71322 Positive_regulation of Binding of Oprd1 4 0.33 0.97 3.87
133 INT80882 Negative_regulation of Phosphorylation of OPRM1 4 0.45 0.21 3.68
134 INT89329 Regulation of Gene_expression of Drd3 4 0.61 0.72 3.56
135 INT41296 Protein_catabolism of Oprd1 8 0.85 0.79 3.48
136 INT5929 Positive_regulation of Regulation of Oprm1 4 0.50 0.56 3.48
137 INT60646 Regulation of Gene_expression of Oprd1 4 0.60 1.76 3.46
138 INT8731 Regulation of Localization of Oprm1 3 0.43 0.25 3.4
139 INT13347 Regulation of Negative_regulation of OPRM1 5 0.45 0.64 3.38
140 INT62901 Positive_regulation of Gene_expression of Drd1a 2 0.57 0.66 3.35
141 INT68812 Regulation of Regulation of Oprm1 5 0.40 0.16 3.28
142 INT54060 Regulation of Transcription of Oprd1 3 0.57 0.59 3.18
143 INT13335 Negative_regulation of Gene_expression of Drd1a 6 0.34 0.8 3.16
144 INT82035 Negative_regulation of Phosphorylation of Oprd1 3 0.13 0 3.16
145 INT18365 Positive_regulation of Regulation of Drd1a 4 0.50 1.74 3.04
146 INT59455 Localization of Oprd1 3 0.20 0.22 3.01
147 INT54632 Negative_regulation of Gene_expression of Oprd1 5 0.58 2.22 2.9
148 INT82992 Gene_expression of DRD3 3 0.50 2.12 2.88
149 INT113077 Positive_regulation of Phosphorylation of Drd1a 1 0.11 0.15 2.87
150 INT99419 Regulation of Drd3 7 0.48 1.89 2.81
151 INT28729 Negative_regulation of Negative_regulation of Oprd1 3 0.43 0.33 2.79
152 INT70377 Regulation of Transcription of Oprm1 3 0.47 0.93 2.78
153 INT34501 Positive_regulation of Positive_regulation of Oprd1 4 0.43 0.31 2.77
154 INT16715 Positive_regulation of Transcription of Oprd1 3 0.66 0.6 2.74
155 INT89327 Positive_regulation of Gene_expression of Drd3 4 0.54 0.32 2.64
156 INT64248 Positive_regulation of Positive_regulation of Drd1a 6 0.45 1.97 2.62
157 INT89326 Transcription of Drd3 4 0.37 0.67 2.58
158 INT89992 Positive_regulation of Gene_expression of Drd1a 5 0.39 2.11 2.54
159 INT64062 Negative_regulation of Regulation of OPRM1 2 0.41 0.3 2.48
160 INT86462 Transcription of Drd1a 3 0.44 1.86 2.36
161 INT63394 Gene_expression of Drd5 7 0.76 1.85 2.3
162 INT53605 Regulation of Binding of Oprd1 2 0.42 0 2.26
163 INT51047 Regulation of Drd3 4 0.53 2 2.2
164 INT71952 Regulation of Negative_regulation of Oprm1 3 0.43 0.09 2.18
165 INT24407 Negative_regulation of Binding of Drd1a 3 0.25 0.81 2.18
166 INT63392 Positive_regulation of Drd5 5 0.46 1.73 2.08
167 INT179311 Transcription of GNAS 2 0.10 0.67 2.08
168 INT50782 Positive_regulation of Phosphorylation of Oprd1 1 0.16 0 2.07
169 INT21046 Regulation of Positive_regulation of Drd1a 3 0.44 0.09 2.06
170 INT105008 Binding of DRD3 5 0.36 3.15 2.05
171 INT108903 Negative_regulation of GNAS 7 0.57 1.58 2.04
172 INT13837 Negative_regulation of Positive_regulation of Drd1a 2 0.43 1.43 2.01
173 INT32980 Positive_regulation of Regulation of OPRM1 2 0.45 0 1.98
174 INT62522 Regulation of Phosphorylation of Oprm1 3 0.13 0 1.96
175 INT7829 Negative_regulation of Positive_regulation of Oprd1 2 0.30 0.41 1.95
176 INT142684 Protein_catabolism of OPRM1 2 0.66 0.48 1.81
177 INT89330 Positive_regulation of Binding of Drd3 1 0.31 0.16 1.81
178 INT62972 Gene_expression of Adcy5 3 0.67 0.23 1.72
179 INT267108 Negative_regulation of Gene_expression of DRD3 2 0.26 1.53 1.69
180 INT130552 Negative_regulation of Localization of Oprm1 2 0.31 0.37 1.53
181 INT9953 Positive_regulation of Gnas 10 0.34 3.21 1.51
182 INT50777 Phosphorylation of Oprd1 2 0.32 0 1.51
183 INT13013 Positive_regulation of Adcy5 4 0.67 0.3 1.49
184 INT121347 Binding of GNAS 8 0.13 3.99 1.47
185 INT140305 Negative_regulation of Binding of Drd1a 2 0.21 0.54 1.46
186 INT105997 Positive_regulation of Protein_catabolism of Oprm1 2 0.66 0.41 1.45
187 INT21106 Regulation of Phosphorylation of Oprm1 3 0.61 0 1.43
188 INT113079 Regulation of Phosphorylation of Drd1a 1 0.06 0.07 1.43
189 INT336571 Gene_expression of DRD5 1 0.06 0.73 1.41
190 INT162308 Phosphorylation of GNAS 3 0.01 1.71 1.4
191 INT115804 Regulation of Localization of OPRM1 2 0.33 0.12 1.33
192 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32
193 INT85667 Negative_regulation of Negative_regulation of Oprm1 3 0.37 0.54 1.31
194 INT112063 Regulation of Gene_expression of Drd3 2 0.09 1.84 1.31
195 INT50776 Regulation of Phosphorylation of Oprd1 1 0.01 0 1.3
196 INT61429 Gene_expression of Adcy5 6 0.60 1.49 1.27
197 INT67450 Negative_regulation of Localization of OPRM1 2 0.06 0.24 1.26
198 INT82991 Regulation of Gene_expression of DRD3 1 0.23 0.59 1.26
199 INT82988 Regulation of Transcription of DRD3 1 0.38 0.59 1.26
200 INT82987 Transcription of DRD3 1 0.58 0.59 1.25
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