GO:0007193

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Name inhibition of adenylate cyclase activity by G-protein signaling pathway
Categary Process
Go Slim No
Go Link GO:0007193
Unique Molecular Interactions 1419
Total Molecular Interactions 1911
Total Single Events 17264
Pain Genes Associated 37

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for inhibition of adenylate cyclase activity by G-protein signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for inhibition of adenylate cyclase activity by G-protein signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
3 INT21276 Binding of Oprd1 and Penk 9 0.54 1.14 8.28
4 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8
5 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
6 INT125407 Binding of OPRL1 and PTPRM 1 0.03 0.72 4.67
7 INT64480 Binding of OPRL1 and PNOC 2 0.33 0.23 4.38
8 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
9 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 0.30 0.91 4.18
10 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
11 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
12 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
13 INT249566 Binding of Oprd1 and Psmd1 1 0.01 0.82 3.8
14 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
15 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
16 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
17 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
18 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
19 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
20 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
21 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 3 0.00 0.63 3.1
22 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
23 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
24 INT264929 Binding of Cnr1 and Gnaz 1 0.18 1.71 2.89
25 INT114126 Binding of APLNR and OPRL1 1 0.01 0.47 2.85
26 INT137230 Trh Regulation of Gene_expression of Oprd1 1 0.01 1.62 2.75
27 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
28 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
29 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
30 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
31 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59
32 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
33 INT69665 Binding of Oprd1 and Pnoc 5 0.35 0.4 2.5
34 INT249567 Positive_regulation of Binding of Oprd1 and Psmd1 1 0.01 0.66 2.5
35 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
36 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
37 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
38 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
39 INT5486 Oprd1 Regulation of Cck 1 0.21 0 2.16
40 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
41 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
42 INT133946 Binding of DNM2 and OPRK1 1 0.11 0 2.1
43 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
44 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
45 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07
46 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
47 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
48 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
49 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
50 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
51 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
52 INT68272 Binding of Oprd1 and G2e3 1 0.00 0.11 1.93
53 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
54 INT65025 Binding of Oprm1 and Hps4 1 0.01 0 1.93
55 INT83418 Binding of OPRL1 and Ntrk1 1 0.02 0 1.91
56 INT169498 Binding of Oprm1 and Mirlet7a-1 1 0.32 0 1.9
57 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
58 INT153582 Binding of Oprm1 and Hint1 1 0.01 0 1.87
59 INT211747 Negative_regulation of Binding of Oprm1 and Mors1 1 0.09 0 1.86
60 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85
61 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
62 INT72468 Negative_regulation of Binding of OPRL1 and PNOC 1 0.40 0 1.83
63 INT119917 Zfp821 Positive_regulation of Positive_regulation of Oprd1 1 0.01 0 1.82
64 INT169502 Mirlet7a-1 Regulation of Oprm1 1 0.53 0 1.81
65 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
66 INT70225 oh Regulation of Oprd1 1 0.20 0.13 1.8
67 INT168925 Binding of Oprm1 and Imraq2 1 0.04 0.13 1.78
68 INT168924 Positive_regulation of Binding of Oprm1 and Imraq2 1 0.06 0.13 1.78
69 INT211746 Binding of Oprm1 and Mors1 1 0.08 0 1.78
70 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
71 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
72 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
73 INT129953 Oprd1 Regulation of Cspg5 1 0.17 0.15 1.74
74 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
75 INT37840 Binding of Cyp27b1 and Oprd1 1 0.01 0 1.73
76 INT6407 Binding of Lama5 and Oprm1 1 0.02 0.08 1.72
77 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
78 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
79 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
80 INT69666 Binding of OPRL1 and Pnoc 2 0.45 0.06 1.66
81 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
82 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
83 INT103725 Negative_regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.17 0.38 1.65
84 INT315180 Gene_expression of Mors1 Positive_regulation of Gene_expression of Oprm1 1 0.03 0.48 1.64
85 INT134742 Binding of OPRM1 and SV2A 1 0.33 0.18 1.64
86 INT103726 Regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.10 0.38 1.64
87 INT61049 Binding of Oprd1 and Negative_regulation of Gene_expression of Odc1 1 0.21 0 1.64
88 INT315181 Gene_expression of Mors1 Positive_regulation of Oprm1 1 0.03 0.48 1.64
89 INT90046 Oprm1 Positive_regulation of P9Ehs1 2 0.16 0.92 1.63
90 INT199501 Pdyn Positive_regulation of Oprm1 1 0.01 0.86 1.63
91 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
92 INT61674 Gpm6a Regulation of Oprd1 1 0.01 0.07 1.62
93 INT109525 Binding of DMRT1 and Oprm1 1 0.08 0 1.62
94 INT140341 Ngf Positive_regulation of Gene_expression of Oprm1 1 0.02 0.33 1.59
95 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
96 INT317558 Binding of Oprm1 and Rgs17 1 0.18 0 1.59
97 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
98 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
99 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
100 INT148821 Binding of Oprm1 and Grin1 1 0.05 0.24 1.55
101 INT148820 Binding of Oprm1 and Naa15 1 0.02 0.24 1.55
102 INT8734 Pebp1 Positive_regulation of Oprd1 1 0.01 0 1.54
103 INT111828 UPB1 Positive_regulation of Oprm1 1 0.00 0.85 1.53
104 INT72666 Binding of ODT and Oprm1 1 0.03 0.53 1.5
105 INT117008 Sfpi1 Regulation of Oprm1 1 0.56 0.56 1.49
106 INT8735 Oprm1 Positive_regulation of Scn4a 1 0.00 0 1.49
107 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47
108 INT317509 Oprm1 Negative_regulation of Phosphorylation of Oprd1 1 0.00 0 1.46
109 INT141673 Oprm1 Positive_regulation of Negative_regulation of Ltp 1 0.13 0 1.46
110 INT141676 OPRM1 Positive_regulation of Ltp 1 0.04 0 1.46
111 INT141674 Oprm1 Positive_regulation of Ltp 1 0.13 0 1.46
112 INT141675 OPRM1 Positive_regulation of Negative_regulation of Ltp 1 0.04 0 1.46
113 INT131039 Binding of Oprm1 and Prf1 1 0.17 0 1.45
114 INT83416 Binding of OPRK1 and Ntrk1 1 0.02 0 1.45
115 INT131041 Negative_regulation of Binding of Oprm1 and Prf1 1 0.21 0 1.45
116 INT131040 Binding of Oprm1 and S100a9 1 0.24 0 1.45
117 INT161858 OPRM1 Positive_regulation of GRIN1 1 0.50 0.12 1.45
118 INT153581 Binding of Oprm1 and Prkcg 1 0.00 0 1.44
119 INT69337 Oprm1 Positive_regulation of Atxn2l 1 0.01 0.27 1.43
120 INT128915 PENK Regulation of Gene_expression of OPRM1 1 0.22 0.07 1.43
121 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43
122 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41
123 INT329451 Binding of Oprd1 and Tacr1 1 0.05 0.23 1.41
124 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41
125 INT142852 Oprm1 Positive_regulation of Oprd1 1 0.41 0.06 1.41
126 INT329452 Binding of Tac1 and Oprd1 1 0.01 0.23 1.4
127 INT133937 Binding of OPRK1 and ARFGEF1 1 0.01 0 1.39
128 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
129 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 0.03 0 1.39
130 INT6466 Binding of Npr1 and Oprd1 1 0.01 0 1.37
131 INT51203 Binding of OPRK1 and OPRM1 2 0.29 0.3 1.36
132 INT160590 CSF2 Positive_regulation of Gene_expression of OPRM1 1 0.16 0.54 1.35
133 INT139987 Oprm1 Positive_regulation of Localization of Oprl1 1 0.16 0.17 1.35
134 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
135 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
136 INT160587 IFNG Positive_regulation of Gene_expression of OPRM1 1 0.18 0.54 1.35
137 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
138 INT160589 IL4 Positive_regulation of Gene_expression of OPRM1 1 0.13 0.54 1.35
139 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
140 INT249565 Binding of Gabrg1 and Oprd1 1 0.00 0.1 1.33
141 INT13756 Binding of Oprd1 and Scn4a 1 0.02 0 1.32
142 INT13755 Binding of Oprd1 and Ap2m1 1 0.20 0 1.32
143 INT51200 Binding of OPRM1 and PENK 2 0.17 0.23 1.31
144 INT38624 Binding of Oprm1 and Insrr 2 0.01 0.24 1.31
145 INT317519 Grin1 Positive_regulation of Negative_regulation of Oprm1 1 0.14 0 1.31
146 INT130786 Positive_regulation of Oprm1 Positive_regulation of Arc 1 0.27 0.9 1.31
147 INT168229 Oprm1 Regulation of Cea 1 0.10 0.26 1.3
148 INT57263 Binding of Oprd1 and Atxn2l 1 0.02 0 1.29
149 INT128310 Oprm1 Positive_regulation of Oprm1 1 0.00 0.1 1.29
150 INT57262 Binding of Gria4 and Oprd1 1 0.06 0 1.29
151 INT89943 Binding of Oprm1 and Il2 1 0.03 0.53 1.28
152 INT114929 Positive_regulation of Binding of Oprm1 and Crebbp 1 0.06 0.14 1.28
153 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
154 INT64749 Negative_regulation of Binding of Oprm1 and Pck1 1 0.47 0.21 1.27
155 INT114925 Binding of Oprm1 and Crebbp 1 0.06 0.14 1.27
156 INT34393 Oprd1 Negative_regulation of Adcy1 1 0.36 0 1.27
157 INT124767 Creb1 Regulation of Oprm1 1 0.45 0 1.26
158 INT207548 U Negative_regulation of Gene_expression of Oprm1 1 0.01 0.46 1.26
159 INT121464 Negative_regulation of Oprm1 Positive_regulation of Dnm2 1 0.34 0 1.26
160 INT67383 Binding of OPRK1 and Pdyn 2 0.00 0 1.25
161 INT110542 SIGMAR1 Regulation of OPRM1 1 0.04 0.33 1.25
162 INT110543 SIGMAR1 Regulation of Gene_expression of OPRM1 1 0.04 0.33 1.25
163 INT87375 Binding of Gabrg1 and Oprm1 1 0.00 0.83 1.25
164 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25
165 INT126801 Regulation of Binding of Oprm1 and Penk 1 0.34 0.4 1.25
166 INT151444 Binding of Oprm1 and Pag1 1 0.00 1.5 1.24
167 INT121465 Binding of Dnm2 and Oprm1 1 0.23 0 1.24
168 INT167278 Binding of OPRM1 and REST 1 0.08 0.94 1.24
169 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24
170 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
171 INT63864 Oprd1 Regulation of Localization of Prl 2 0.16 0 1.23
172 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 0.02 0 1.23
173 INT58140 Binding of AP2M1 and Oprm1 1 0.01 0.4 1.23
174 INT76165 IGKV2-30 Positive_regulation of Phosphorylation of Oprm1 1 0.00 0.08 1.22
175 INT75229 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.44 0 1.22
176 INT76163 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.02 0.08 1.22
177 INT200455 OPRK1 Positive_regulation of Gene_expression of CCL2 1 0.19 0.07 1.21
178 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
179 INT65203 OPRL1 Negative_regulation of ADCY1 1 0.19 0 1.19
180 INT124157 Oprm1 Negative_regulation of Gnb5 1 0.25 0.4 1.19
181 INT133496 Binding of Oprm1 and Cckbr 1 0.15 0 1.19
182 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
183 INT13203 Oprd1 Negative_regulation of Akr1d1 1 0.01 0 1.18
184 INT49956 OPRM1 Positive_regulation of SGCG 1 0.53 0.3 1.18
185 INT153589 Binding of PRKCI and Oprm1 1 0.06 0 1.17
186 INT153588 Binding of HINT1 and Oprm1 1 0.06 0 1.17
187 INT13205 Oprd1 Negative_regulation of Npr1 2 0.01 0 1.16
188 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
189 INT215648 Binding of Adora1 and Gabrd 1 0.03 0.06 1.16
190 INT200312 Rest Regulation of Oprm1 1 0.23 0.27 1.16
191 INT137144 ITIH4 Regulation of OPRM1 1 0.20 1.13 1.16
192 INT125696 Binding of OPRM1 and SNRNP70 1 0.06 0.99 1.15
193 INT326665 Cpe Positive_regulation of Oprd1 1 0.01 1.24 1.15
194 INT199493 Ngf Regulation of Oprd1 1 0.05 1.05 1.15
195 INT88778 Binding of Oprm1 and Pomc 3 0.21 0.56 1.14
196 INT264930 Gnaz Positive_regulation of Negative_regulation of Cnr1 1 0.20 0 1.14
197 INT65204 PNOC Negative_regulation of ADCY1 1 0.07 0 1.14
198 INT317549 Negative_regulation of Camk2a Negative_regulation of Phosphorylation of Oprm1 1 0.19 0 1.14
199 INT110522 Oprm1 Positive_regulation of Oprk1 1 0.11 0 1.12
200 INT221183 Binding of OPRM1 and Mors1 1 0.00 0 1.12

Single Events

The table below shows the top 100 pain related interactions that have been reported for inhibition of adenylate cyclase activity by G-protein signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in inhibition of adenylate cyclase activity by G-protein signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
2 INT5660 Binding of Oprd1 477 0.48 71.86 342.06
3 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32
4 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
5 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41
6 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
7 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9
8 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
9 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61
10 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
11 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
12 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93
13 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11
14 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
15 INT6042 Binding of Oprm1 248 0.48 31.77 154.34
16 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
17 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93
18 INT12569 Localization of Oprd1 94 0.81 23.81 104.56
19 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
20 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
21 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
22 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
23 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9
24 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
25 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
26 INT20964 Gene_expression of OPRK1 96 0.78 23.54 58.18
27 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
28 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54
29 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78
30 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
31 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12
32 INT10304 Binding of OPRK1 89 0.48 9.28 49.42
33 INT32718 Gene_expression of OPRD1 82 0.76 9.43 48.38
34 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
35 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69
36 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
37 INT7828 Positive_regulation of Oprd1 55 0.69 14.11 42.86
38 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
39 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58
40 INT14137 Localization of Oprm1 56 0.81 2.88 36.09
41 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
42 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29
43 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52
44 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03
45 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95
46 INT12397 Gene_expression of Oprd1 53 0.78 9.1 31.31
47 INT7845 Regulation of OPRK1 44 0.62 4.54 30.49
48 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
49 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66
50 INT15000 Transcription of Oprd1 32 0.72 5.7 29.22
51 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
52 INT5771 Binding of Oprd1 37 0.48 2.6 27.54
53 INT72677 Regulation of Gene_expression of Oprm1 45 0.62 13.95 26.75
54 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48
55 INT6934 Binding of OPRD1 51 0.48 7.72 25.73
56 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52
57 INT12475 Gene_expression of OPRL1 35 0.77 3.63 23.11
58 INT30386 Negative_regulation of OPRD1 33 0.52 4.34 23.06
59 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79
60 INT57253 Negative_regulation of Binding of Oprm1 24 0.43 5.27 22.67
61 INT31393 Positive_regulation of Localization of Oprd1 10 0.66 7.32 21.23
62 INT27529 Phosphorylation of Oprd1 23 0.47 1.16 20.18
63 INT49835 Negative_regulation of Positive_regulation of Oprm1 21 0.42 4.11 20.11
64 INT21105 Phosphorylation of Oprm1 32 0.82 0.83 19.29
65 INT40811 Binding of OPRL1 26 0.48 2.76 18.68
66 INT31905 Positive_regulation of Binding of Oprd1 21 0.66 3.31 18.44
67 INT58495 Positive_regulation of Positive_regulation of Oprm1 22 0.49 2.44 17.66
68 INT8332 Positive_regulation of OPRD1 30 0.61 3.88 17.65
69 INT6043 Negative_regulation of Binding of Oprm1 24 0.57 2.67 16.78
70 INT32753 Positive_regulation of Positive_regulation of OPRM1 19 0.62 3.3 16.73
71 INT6066 Negative_regulation of Positive_regulation of Oprd1 15 0.43 1.36 16.63
72 INT33915 Regulation of Positive_regulation of Oprm1 22 0.60 2.44 16.43
73 INT4769 Regulation of OPRD1 20 0.44 2.05 15.97
74 INT12617 Regulation of ADCY1 41 0.61 7.38 15.94
75 INT68811 Regulation of Transcription of Oprm1 19 0.61 3.67 15.15
76 INT25872 Positive_regulation of Adora1 19 0.69 4.9 15.01
77 INT12658 Regulation of Binding of Oprm1 9 0.57 2.44 14.95
78 INT29352 Negative_regulation of Oprd1 16 0.58 6.51 14.6
79 INT54284 Negative_regulation of Gene_expression of Oprd1 16 0.42 4.56 14.34
80 INT76863 Negative_regulation of Gene_expression of OPRM1 21 0.57 6.56 13.69
81 INT80883 Positive_regulation of Phosphorylation of OPRM1 13 0.69 1.03 13.65
82 INT69166 Positive_regulation of P2ry1 35 0.67 8.41 13.63
83 INT68814 Positive_regulation of Transcription of Oprm1 16 0.60 2.72 13.57
84 INT20881 Negative_regulation of OPRK1 20 0.43 3.73 13.37
85 INT62523 Positive_regulation of Phosphorylation of Oprm1 11 0.53 0.75 12.51
86 INT76428 Gene_expression of Sstr2 24 0.76 6.09 12.32
87 INT72804 Negative_regulation of OPRL1 16 0.43 1.79 12.14
88 INT11429 Gene_expression of ADCY1 26 0.74 5.89 11.93
89 INT93122 Gene_expression of P2ry1 32 0.75 11.82 11.42
90 INT40486 Positive_regulation of Positive_regulation of ADCY1 20 0.48 4.29 11.33
91 INT6044 Regulation of Binding of Oprm1 16 0.61 3.01 11.11
92 INT59766 Positive_regulation of Negative_regulation of Oprm1 9 0.50 1.31 11.08
93 INT19155 Binding of Adora1 25 0.47 6.41 10.72
94 INT13423 Localization of Sstr2 17 0.78 0.56 10.47
95 INT71592 Negative_regulation of Gene_expression of Oprm1 11 0.58 4.03 10.37
96 INT12620 Negative_regulation of Negative_regulation of ADCY1 16 0.44 2.98 10.1
97 INT33957 Positive_regulation of OPRL1 14 0.68 2.89 9.72
98 INT49483 Regulation of Positive_regulation of Oprm1 8 0.61 2.34 9.4
99 INT114406 Gene_expression of Adora1 28 0.72 6.83 9.13
100 INT20835 Negative_regulation of Negative_regulation of Oprm1 10 0.43 0.56 8.96
101 INT33209 Positive_regulation of Binding of OPRM1 8 0.68 0.63 8.95
102 INT76162 Positive_regulation of Phosphorylation of Oprm1 11 0.69 0.64 8.72
103 INT98835 Positive_regulation of Transcription of Oprm1 15 0.65 2.47 8.67
104 INT18021 Positive_regulation of Binding of Oprm1 16 0.70 2.53 8.38
105 INT54681 Negative_regulation of Positive_regulation of ADCY1 16 0.38 2.7 8.14
106 INT50191 Positive_regulation of Gene_expression of OPRK1 9 0.67 3.44 7.91
107 INT31394 Negative_regulation of Localization of Oprd1 3 0.39 2.38 7.89
108 INT91238 Regulation of Negative_regulation of Oprm1 6 0.45 1.4 7.85
109 INT264910 Positive_regulation of Gnaz 1 0.30 0 7.82
110 INT9350 Regulation of ADORA1 9 0.12 1.53 7.79
111 INT31060 Negative_regulation of Binding of OPRM1 12 0.37 2.65 7.75
112 INT101721 Positive_regulation of Transcription of OPRM1 8 0.48 1.22 7.74
113 INT62372 Positive_regulation of Localization of Oprm1 8 0.50 0.46 7.71
114 INT101699 Regulation of Adora1 14 0.61 3.7 7.59
115 INT121815 Regulation of Positive_regulation of OPRM1 7 0.62 0.75 7.36
116 INT20845 Positive_regulation of Negative_regulation of Oprd1 7 0.70 1.81 7.33
117 INT116163 Gene_expression of S1pr1 29 0.78 14.11 7.27
118 INT6239 Regulation of Regulation of Oprd1 7 0.45 0.34 7.26
119 INT5311 Regulation of Negative_regulation of Oprd1 11 0.43 0.99 7.23
120 INT40159 Negative_regulation of Adora1 13 0.51 3.51 7.13
121 INT76197 Positive_regulation of ADORA1 7 0.59 5.06 7
122 INT16628 Negative_regulation of Positive_regulation of Oprm1 9 0.43 0.89 6.92
123 INT62524 Negative_regulation of Phosphorylation of Oprm1 7 0.59 0.08 6.92
124 INT75228 Positive_regulation of Negative_regulation of Oprm1 8 0.49 0.95 6.9
125 INT9167 Binding of Adora1 6 0.40 0.53 6.9
126 INT76255 Gene_expression of ADORA1 11 0.78 2.51 6.85
127 INT12699 Transcription of OPRK1 11 0.52 0.08 6.66
128 INT54062 Transcription of Oprd1 11 0.68 1.05 6.65
129 INT5932 Regulation of Regulation of Oprm1 7 0.61 0.44 6.47
130 INT42832 Negative_regulation of Positive_regulation of OPRM1 6 0.36 0.96 6.35
131 INT54747 Localization of OPRD1 7 0.73 0.69 6.27
132 INT97600 Regulation of Transcription of OPRM1 8 0.52 1.14 6.21
133 INT53135 Positive_regulation of Localization of Oprm1 2 0.50 0 6.12
134 INT20899 Negative_regulation of GNAI1 12 0.57 4.24 6.07
135 INT91575 Positive_regulation of Phosphorylation of Oprd1 8 0.02 0.23 6.07
136 INT27118 Regulation of Binding of OPRM1 10 0.62 1.18 5.97
137 INT76741 Localization of OPRK1 7 0.68 0.22 5.9
138 INT29051 Regulation of OPRL1 6 0.60 1.29 5.81
139 INT26555 Regulation of Positive_regulation of Oprd1 6 0.59 2.47 5.76
140 INT92280 Transcription of OPRL1 10 0.70 1.36 5.68
141 INT110545 Regulation of Regulation of OPRM1 7 0.42 1.68 5.67
142 INT95170 Localization of P2ry1 10 0.78 5.08 5.63
143 INT111683 Gene_expression of P2ry1 22 0.74 7.96 5.59
144 INT112927 Negative_regulation of Localization of Oprm1 4 0.39 0.31 5.59
145 INT32979 Positive_regulation of Localization of OPRM1 5 0.50 0 5.54
146 INT163217 Transcription of Sstr2 5 0.67 0.62 5.42
147 INT80881 Phosphorylation of ADCY1 7 0.69 1.22 5.29
148 INT74182 Positive_regulation of Binding of OPRK1 8 0.49 1.39 5.25
149 INT139238 Positive_regulation of P2ry1 19 0.60 9.22 5.15
150 INT29354 Regulation of Binding of OPRK1 7 0.60 1.72 5.04
151 INT109848 Gene_expression of P2RY1 26 0.62 6.71 4.98
152 INT65509 Regulation of P2ry1 13 0.60 2.38 4.96
153 INT42833 Positive_regulation of Negative_regulation of OPRM1 6 0.48 0.12 4.95
154 INT62920 Regulation of Gnai1 3 0.52 0.08 4.78
155 INT17391 Gene_expression of GNAI1 11 0.75 5.26 4.7
156 INT17393 Positive_regulation of GNAI1 17 0.49 2.42 4.66
157 INT14574 Positive_regulation of Negative_regulation of ADCY1 9 0.66 2.45 4.39
158 INT23738 Regulation of Transcription of Oprd1 6 0.26 0.48 4.3
159 INT102363 Negative_regulation of Positive_regulation of OPRK1 7 0.43 0.99 4.25
160 INT105998 Protein_catabolism of Oprm1 5 0.95 0.88 4.08
161 INT140542 Gene_expression of SSTR2 18 0.65 13.58 3.94
162 INT29671 Regulation of Localization of Oprd1 4 0.24 1.04 3.92
163 INT65460 Positive_regulation of Gene_expression of Oprd1 8 0.69 1.87 3.87
164 INT71322 Positive_regulation of Binding of Oprd1 4 0.33 0.97 3.87
165 INT142984 Positive_regulation of S1pr1 13 0.70 7.9 3.84
166 INT65527 Positive_regulation of Positive_regulation of Adora1 4 0.46 0.67 3.71
167 INT80882 Negative_regulation of Phosphorylation of OPRM1 4 0.45 0.21 3.68
168 INT87408 Negative_regulation of ADCY2 3 0.01 0.1 3.68
169 INT13425 Positive_regulation of Localization of Sstr2 4 0.67 0.19 3.65
170 INT215604 Localization of Adora1 10 0.78 1.47 3.49
171 INT41296 Protein_catabolism of Oprd1 8 0.85 0.79 3.48
172 INT5929 Positive_regulation of Regulation of Oprm1 4 0.50 0.56 3.48
173 INT60646 Regulation of Gene_expression of Oprd1 4 0.60 1.76 3.46
174 INT40653 Gene_expression of Sstr2 6 0.54 1.28 3.43
175 INT52392 Positive_regulation of Gene_expression of OPRD1 6 0.64 0.23 3.43
176 INT87281 Localization of ADCY1 7 0.64 1.84 3.42
177 INT66782 Negative_regulation of Gene_expression of OPRK1 4 0.28 1.42 3.41
178 INT8731 Regulation of Localization of Oprm1 3 0.43 0.25 3.4
179 INT72472 Positive_regulation of Gene_expression of OPRL1 4 0.68 0.07 3.39
180 INT13347 Regulation of Negative_regulation of OPRM1 5 0.45 0.64 3.38
181 INT68812 Regulation of Regulation of Oprm1 5 0.40 0.16 3.28
182 INT74962 Phosphorylation of OPRD1 5 0.82 0.18 3.26
183 INT54060 Regulation of Transcription of Oprd1 3 0.57 0.59 3.18
184 INT38030 Positive_regulation of P2RY1 15 0.67 5.54 3.17
185 INT82035 Negative_regulation of Phosphorylation of Oprd1 3 0.13 0 3.16
186 INT31912 Regulation of Binding of OPRD1 3 0.25 0.93 3.11
187 INT13422 Regulation of Localization of Sstr2 4 0.44 0 3.1
188 INT13179 Regulation of Positive_regulation of ADCY1 5 0.34 0.89 3.08
189 INT101477 Binding of ADORA1 8 0.31 0.42 3.07
190 INT123802 Localization of Sstr2 8 0.80 3.54 3.01
191 INT59455 Localization of Oprd1 3 0.20 0.22 3.01
192 INT57145 Transcription of OPRD1 6 0.61 0.34 2.99
193 INT59309 Negative_regulation of Gene_expression of ADCY1 3 0.42 1.04 2.98
194 INT80521 Negative_regulation of Binding of OPRK1 4 0.43 0.8 2.93
195 INT106401 Negative_regulation of Gene_expression of OPRL1 3 0.40 0.07 2.92
196 INT54632 Negative_regulation of Gene_expression of Oprd1 5 0.58 2.22 2.9
197 INT69641 Positive_regulation of ADCY2 5 0.32 0.18 2.87
198 INT54178 Regulation of Adora1 5 0.39 0.29 2.85
199 INT24279 Gene_expression of INSL3 11 0.75 12.46 2.8
200 INT30815 Binding of ADCY1 7 0.36 0.21 2.79
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