GO:0007194

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Name negative regulation of adenylate cyclase activity
Categary Process
Go Slim No
Go Link GO:0007194
Unique Molecular Interactions 332
Total Molecular Interactions 460
Total Single Events 3949
Pain Genes Associated 24

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of adenylate cyclase activity. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of adenylate cyclase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
2 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
3 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
4 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
5 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
6 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
7 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
8 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
9 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
10 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
11 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
12 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
13 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94
14 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
15 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
16 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
17 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
18 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
19 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
20 INT134742 Binding of OPRM1 and SV2A 1 0.33 0.18 1.64
21 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
22 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
23 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
24 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
25 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47
26 INT141676 OPRM1 Positive_regulation of Ltp 1 0.04 0 1.46
27 INT141675 OPRM1 Positive_regulation of Negative_regulation of Ltp 1 0.04 0 1.46
28 INT161858 OPRM1 Positive_regulation of GRIN1 1 0.50 0.12 1.45
29 INT128915 PENK Regulation of Gene_expression of OPRM1 1 0.22 0.07 1.43
30 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
31 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
32 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41
33 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
34 INT51203 Binding of OPRK1 and OPRM1 2 0.29 0.3 1.36
35 INT160590 CSF2 Positive_regulation of Gene_expression of OPRM1 1 0.16 0.54 1.35
36 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
37 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
38 INT160587 IFNG Positive_regulation of Gene_expression of OPRM1 1 0.18 0.54 1.35
39 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
40 INT160589 IL4 Positive_regulation of Gene_expression of OPRM1 1 0.13 0.54 1.35
41 INT51200 Binding of OPRM1 and PENK 2 0.17 0.23 1.31
42 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
43 INT154203 Binding of Pick1 and Grm7 1 0.41 1.64 1.28
44 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
45 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
46 INT111211 Binding of Drd4 and Chdh 1 0.01 1.34 1.26
47 INT110542 SIGMAR1 Regulation of OPRM1 1 0.04 0.33 1.25
48 INT110543 SIGMAR1 Regulation of Gene_expression of OPRM1 1 0.04 0.33 1.25
49 INT167278 Binding of OPRM1 and REST 1 0.08 0.94 1.24
50 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
51 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
52 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
53 INT49956 OPRM1 Positive_regulation of SGCG 1 0.53 0.3 1.18
54 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
55 INT137144 ITIH4 Regulation of OPRM1 1 0.20 1.13 1.16
56 INT125696 Binding of OPRM1 and SNRNP70 1 0.06 0.99 1.15
57 INT221183 Binding of OPRM1 and Mors1 1 0.00 0 1.12
58 INT113540 Binding of OPRM1 and Tac1 1 0.04 0.1 1.1
59 INT127133 Positive_regulation of OPRM1 Positive_regulation of Protein_catabolism of SUCLG2 1 0.20 0.2 1.1
60 INT90145 Binding of OPRL1 and OPRM1 2 0.27 0.31 1.08
61 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 0.40 0 1.05
62 INT97011 Binding of CALM3 and OPRM1 1 0.35 0 1.05
63 INT133075 TFAM Positive_regulation of Transcription of OPRM1 1 0.03 0 1.04
64 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 0.35 0 1.04
65 INT51204 Positive_regulation of Binding of OPRK1 and OPRM1 1 0.38 0.3 1.03
66 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1
67 INT1415 Binding of OPRM1 and POMC 3 0.16 0.3 0.98
68 INT51201 Negative_regulation of Binding of OPRM1 and PENK 1 0.20 0.23 0.98
69 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
70 INT157522 GRM5 Regulation of Gene_expression of OPRM1 1 0.28 0 0.97
71 INT40287 OPRM1 Positive_regulation of Negative_regulation of Prl 1 0.00 0.93 0.96
72 INT133076 STAT6 Positive_regulation of OPRM1 1 0.38 0 0.95
73 INT152388 Binding of NFKB1 and OPRM1 1 0.04 0.14 0.94
74 INT152390 Negative_regulation of Binding of JUN and OPRM1 1 0.13 0.14 0.94
75 INT152387 Binding of JUN and OPRM1 1 0.15 0.14 0.94
76 INT152389 Negative_regulation of Binding of NFKB1 and OPRM1 1 0.05 0.14 0.94
77 INT128860 NR1H4 Negative_regulation of Gene_expression of OPRM1 1 0.15 0.31 0.92
78 INT309708 Palm Regulation of Positive_regulation of Penk 1 0.19 1.25 0.91
79 INT89314 Binding of CRYGS and OPRM1 1 0.07 0.08 0.91
80 INT113946 Binding of FLNA and OPRM1 1 0.10 0.37 0.9
81 INT128859 Positive_regulation of RXRA Regulation of Gene_expression of OPRM1 1 0.05 0.26 0.9
82 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
83 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86
84 INT36008 Negative_regulation of Binding of Drd2 and Prl 1 0.01 2.11 0.85
85 INT128701 Ednra Regulation of EDNRB 1 0.17 0.58 0.84
86 INT97012 Binding of CALM1 and OPRM1 1 0.18 0 0.82
87 INT77393 Binding of ARRB1 and OPRM1 1 0.15 0 0.82
88 INT89529 OPRM1 Regulation of CALM1 1 0.27 0 0.81
89 INT78348 Binding of GALR1 and GAL 4 0.41 1.47 0.8
90 INT90143 Negative_regulation of Binding of OPRL1 and OPRM1 1 0.31 0.07 0.8
91 INT151807 Binding of NFATC1 and OPRM1 1 0.19 0 0.79
92 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77
93 INT133074 CNR2 Positive_regulation of Transcription of OPRM1 1 0.11 0 0.77
94 INT151808 NFATC1 Positive_regulation of Positive_regulation of OPRM1 1 0.20 0 0.76
95 INT334833 Binding of Drd2 and Ncs1 1 0.05 1.11 0.76
96 INT151339 Positive_regulation of Binding of Drd2 and P9Ehs1 1 0.11 0.22 0.76
97 INT96795 ITIH4 Positive_regulation of Gene_expression of OPRM1 1 0.49 0.17 0.76
98 INT151340 Binding of Drd2 and P9Ehs1 1 0.09 0.22 0.75
99 INT128861 LBR Positive_regulation of Positive_regulation of OPRM1 1 0.19 0.36 0.75
100 INT137321 Gabrg1 Negative_regulation of Positive_regulation of Gabbr1 1 0.22 0 0.75
101 INT151810 JUND Positive_regulation of Positive_regulation of OPRM1 1 0.26 0 0.74
102 INT151809 JUN Positive_regulation of Positive_regulation of OPRM1 1 0.32 0 0.74
103 INT244062 Gabrg1 Regulation of Gabbr1 1 0.01 0.09 0.74
104 INT133070 Positive_regulation of CNR2 Positive_regulation of Transcription of OPRM1 1 0.11 0 0.74
105 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
106 INT151806 TRAF3IP2 Positive_regulation of Positive_regulation of OPRM1 1 0.06 0 0.74
107 INT157541 Binding of YY1 and Regulation of Gene_expression of OPRM1 1 0.31 1.21 0.72
108 INT137139 ITIH4 Positive_regulation of OPRM1 1 0.37 0.67 0.72
109 INT157539 Binding of SP1 and Regulation of Gene_expression of OPRM1 1 0.36 1.2 0.72
110 INT162162 ARF6 Regulation of OPRM1 1 0.19 0 0.71
111 INT82759 Binding of IGHG3 and OPRM1 2 0.06 0 0.7
112 INT107741 Binding of OPRM1 and Pld2 1 0.01 0 0.69
113 INT130717 Binding of OPRM1 and Positive_regulation of Localization of CCL2 1 0.00 0.72 0.68
114 INT86638 POMC Negative_regulation of Gene_expression of OPRM1 1 0.34 0.33 0.68
115 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
116 INT30503 OPRM1 Regulation of Localization of Prl 1 0.00 0 0.67
117 INT169215 Binding of OPRM1 and CARTPT 1 0.00 0.22 0.67
118 INT169219 Binding of OPRM1 and Coc 1 0.01 0.22 0.67
119 INT137140 HIVEP1 Regulation of Gene_expression of OPRM1 1 0.25 0.69 0.66
120 INT121812 IL6 Regulation of OPRM1 1 0.22 0.27 0.65
121 INT101716 JUND Regulation of Regulation of OPRM1 1 0.09 0.06 0.65
122 INT322385 PPBP Negative_regulation of Positive_regulation of OPRM1 1 0.00 0 0.64
123 INT137145 HIVEP1 Regulation of OPRM1 1 0.10 0.7 0.64
124 INT264775 Binding of Gabbr1 and Abat 1 0.03 0 0.64
125 INT122823 ERCC2 Regulation of Negative_regulation of OPRM1 1 0.23 0.17 0.63
126 INT127056 Ddc Positive_regulation of Transcription of Drd3 1 0.10 0.06 0.63
127 INT30502 Negative_regulation of OPRM1 Negative_regulation of Gh 1 0.00 0 0.63
128 INT209131 Binding of Bcl2a1a and Drd2 1 0.22 0.45 0.62
129 INT101718 PLAT Positive_regulation of Transcription of OPRM1 1 0.22 0.06 0.61
130 INT113962 OPRM1 Regulation of CREB1 1 0.39 0.31 0.6
131 INT126951 PNOC Positive_regulation of OPRM1 1 0.21 0.06 0.6
132 INT137138 ITIH4 Positive_regulation of Positive_regulation of OPRM1 1 0.42 0.55 0.59
133 INT121813 IL6 Positive_regulation of OPRM1 1 0.28 0.28 0.58
134 INT159125 Binding of OPRM1 and SUGT1 1 0.03 0.31 0.57
135 INT45258 SLAMF6 Positive_regulation of Drd2 1 0.00 0 0.55
136 INT210830 OPRM1 Negative_regulation of ADCY1 1 0.00 0.06 0.55
137 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
138 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
139 INT271889 Binding of DRD2 and ANKK1 1 0.23 0.36 0.55
140 INT271888 Binding of DRD2 and DNAJC7 1 0.14 0.36 0.55
141 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54
142 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
143 INT25414 Positive_regulation of Drd2 Positive_regulation of Penk 1 0.38 0 0.53
144 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53
145 INT137143 HIVEP1 Positive_regulation of OPRM1 1 0.15 0.43 0.52
146 INT165045 Drd2 Regulation of Cpe 1 0.07 0 0.52
147 INT165042 Drd2 Regulation of Tac1 1 0.22 0 0.52
148 INT243276 Hrh4 Positive_regulation of Hrh3 1 0.25 0.78 0.52
149 INT113241 TRAF3IP2 Regulation of Transcription of OPRM1 1 0.05 0.82 0.52
150 INT165043 Drd2 Regulation of Cck 1 0.20 0 0.52
151 INT113243 TNF Positive_regulation of Transcription of OPRM1 1 0.23 0.84 0.51
152 INT20580 Drd2 Regulation of Akr1d1 1 0.02 0.26 0.51
153 INT318472 CA2 Regulation of OPRM1 1 0.17 0 0.51
154 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51
155 INT144456 Binding of GPM6A and OPRM1 1 0.07 0 0.5
156 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
157 INT115800 Positive_regulation of HRASLS Positive_regulation of Positive_regulation of OPRM1 1 0.11 0 0.49
158 INT172207 Binding of Drd4 and ADHD1 2 0.03 1.56 0.48
159 INT150536 OPRM1 Positive_regulation of Positive_regulation of IL6 1 0.04 0.38 0.48
160 INT150537 OPRM1 Positive_regulation of Negative_regulation of IL6 1 0.04 0.38 0.48
161 INT150539 OPRM1 Positive_regulation of IL6 1 0.04 0.38 0.48
162 INT150534 OPRM1 Positive_regulation of TNF 1 0.03 0.38 0.48
163 INT150535 OPRM1 Positive_regulation of Positive_regulation of TNF 1 0.08 0.38 0.48
164 INT26338 Binding of OPRM1 and Prl 1 0.02 0.37 0.47
165 INT89647 OPRM1 Regulation of ADCY1 1 0.09 0.09 0.47
166 INT354235 Aif1 Regulation of P2ry12 1 0.20 0.49 0.45
167 INT46008 OPRM1 Regulation of Localization of PRL 1 0.14 0 0.44
168 INT16586 Binding of Drd2 and Nts 1 0.12 0 0.43
169 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42
170 INT89666 Binding of Adora2a and Drd2 1 0.54 0.4 0.42
171 INT113537 Binding of OPRM1 and TACR1 1 0.01 0.1 0.42
172 INT36009 Binding of Drd2 and Prl 1 0.01 1.05 0.42
173 INT160971 Gm2111 Positive_regulation of Grm7 1 0.01 0.16 0.41
174 INT80233 Positive_regulation of OPRM1 Positive_regulation of GNAI1 1 0.23 0 0.41
175 INT27451 OPRM1 Positive_regulation of Localization of Lhb 1 0.01 0.1 0.41
176 INT80232 OPRM1 Positive_regulation of GNAI1 1 0.23 0 0.41
177 INT55588 Drd2 Regulation of Transcription of Gad1 1 0.15 0.07 0.4
178 INT18125 Binding of OPRM1 and Penk 1 0.54 0 0.4
179 INT322409 Positive_regulation of OPRM1 Positive_regulation of Phosphorylation of Akt1 1 0.04 0 0.4
180 INT55589 Drd2 Regulation of Gad1 1 0.15 0.07 0.4
181 INT55460 Binding of OPRM1 and HERPUD1 1 0.11 0 0.4
182 INT152164 Binding of GALR3 and GAL 2 0.31 0.88 0.39
183 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39
184 INT334835 Negative_regulation of Binding of Drd2 and Ncs1 1 0.04 0.56 0.38
185 INT81506 Drd3 Regulation of Positive_regulation of Fos 1 0.28 0 0.37
186 INT353391 Binding of DRD4 and GRB2 1 0.37 0.62 0.37
187 INT37247 Binding of Drd1a and Drd2 1 0.20 0 0.37
188 INT353392 Binding of DRD4 and NCK1 1 0.37 0.62 0.37
189 INT353390 Binding of DRD4 and SRC 1 0.25 0.62 0.37
190 INT327708 Binding of Drd1a and Drd2 1 0.12 0.12 0.37
191 INT138515 Drd3 Negative_regulation of Localization of Tnf 1 0.06 0.4 0.36
192 INT129293 OPRM1 Positive_regulation of Phosphorylation of IKBKE 1 0.05 0.28 0.35
193 INT163906 CCL2 Positive_regulation of CCR2 1 0.18 0.2 0.35
194 INT93201 Positive_regulation of Binding of IGHG3 and OPRM1 1 0.02 0 0.35
195 INT127887 SLC6A3 Regulation of Drd2 1 0.34 0.68 0.34
196 INT43388 OPRM1 Positive_regulation of Localization of PLOD1 1 0.27 0 0.34
197 INT72264 Binding of Hrh1 and Hrh3 1 0.11 0.16 0.34
198 INT51629 Binding of DRD3 and OPRK1 1 0.15 0 0.33
199 INT51630 Binding of ACHE and OPRM1 1 0.11 0 0.33
200 INT98292 IL4 Regulation of Transcription of OPRM1 1 0.05 0 0.33

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of adenylate cyclase activity. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of adenylate cyclase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
2 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
3 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
4 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
5 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
6 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
7 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
8 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
9 INT43507 Gene_expression of Gabbr1 79 0.78 28.53 38.22
10 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
11 INT13501 Binding of Drd2 65 0.48 23.76 35.6
12 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
13 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
14 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
15 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
16 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
17 INT12484 Binding of Drd2 45 0.48 15.17 24.72
18 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
19 INT49774 Binding of DRD2 48 0.48 17.42 20.73
20 INT6351 Positive_regulation of Gabbr1 40 0.64 11.99 19
21 INT32753 Positive_regulation of Positive_regulation of OPRM1 19 0.62 3.3 16.73
22 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
23 INT107585 Gene_expression of CCR2 35 0.71 26.44 14.75
24 INT76863 Negative_regulation of Gene_expression of OPRM1 21 0.57 6.56 13.69
25 INT80883 Positive_regulation of Phosphorylation of OPRM1 13 0.69 1.03 13.65
26 INT148301 Gene_expression of P2ry12 23 0.75 14.24 13.63
27 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
28 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
29 INT5476 Regulation of Gabbr1 21 0.45 4.01 10.26
30 INT75955 Gene_expression of Drd3 19 0.77 4.39 10.07
31 INT6356 Binding of Gabbr1 30 0.48 4.62 9.82
32 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
33 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
34 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
35 INT33209 Positive_regulation of Binding of OPRM1 8 0.68 0.63 8.95
36 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
37 INT73544 Gene_expression of Grm7 34 0.64 31.28 8.04
38 INT6352 Negative_regulation of Gabbr1 7 0.59 4.84 7.93
39 INT31060 Negative_regulation of Binding of OPRM1 12 0.37 2.65 7.75
40 INT101721 Positive_regulation of Transcription of OPRM1 8 0.48 1.22 7.74
41 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
42 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
43 INT121815 Regulation of Positive_regulation of OPRM1 7 0.62 0.75 7.36
44 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
45 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
46 INT64215 Gene_expression of Drd3 16 0.78 5.27 6.71
47 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
48 INT24460 Localization of Drd2 12 0.73 2.96 6.46
49 INT42832 Negative_regulation of Positive_regulation of OPRM1 6 0.36 0.96 6.35
50 INT148308 Regulation of P2ry12 8 0.44 6.2 6.23
51 INT97600 Regulation of Transcription of OPRM1 8 0.52 1.14 6.21
52 INT86772 Localization of Drd2 14 0.80 1.93 6.17
53 INT27118 Regulation of Binding of OPRM1 10 0.62 1.18 5.97
54 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
55 INT42799 Positive_regulation of Drd3 11 0.69 1.1 5.92
56 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
57 INT119523 Gene_expression of EDNRB 32 0.75 26.47 5.75
58 INT110545 Regulation of Regulation of OPRM1 7 0.42 1.68 5.67
59 INT32979 Positive_regulation of Localization of OPRM1 5 0.50 0 5.54
60 INT43506 Regulation of Gene_expression of Gabbr1 2 0.61 4.88 5.52
61 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
62 INT50330 Positive_regulation of Drd3 7 0.70 0.76 5.08
63 INT264765 Positive_regulation of Gene_expression of Gabbr1 2 0.70 4.88 5.07
64 INT42833 Positive_regulation of Negative_regulation of OPRM1 6 0.48 0.12 4.95
65 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
66 INT24011 Binding of Drd3 13 0.47 3.03 4.64
67 INT79682 Gene_expression of Grm7 6 0.75 4.74 4.5
68 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
69 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
70 INT117244 Gene_expression of GABBR1 5 0.33 2.19 4.36
71 INT150464 Positive_regulation of P2ry12 5 0.67 4.39 4.3
72 INT88274 Positive_regulation of Drd4 7 0.69 3.48 4.1
73 INT76714 Binding of Drd3 9 0.37 2.33 4.09
74 INT80882 Negative_regulation of Phosphorylation of OPRM1 4 0.45 0.21 3.68
75 INT79680 Binding of Grm7 6 0.47 2.83 3.58
76 INT89329 Regulation of Gene_expression of Drd3 4 0.61 0.72 3.56
77 INT13347 Regulation of Negative_regulation of OPRM1 5 0.45 0.64 3.38
78 INT183249 Binding of P2ry12 12 0.47 7.4 3.3
79 INT16562 Negative_regulation of Positive_regulation of Gabbr1 5 0.43 2.67 3.24
80 INT109095 Binding of Drd4 7 0.40 3.6 3.18
81 INT102209 Negative_regulation of Gene_expression of Drd2 5 0.59 0.46 3.17
82 INT135316 Gene_expression of Hrh3 9 0.74 5.66 3.14
83 INT148306 Transcription of P2ry12 4 0.69 2.45 3.14
84 INT74596 Gene_expression of Hrh3 11 0.66 0.94 3.12
85 INT120067 Positive_regulation of Gene_expression of CCR2 10 0.46 5.13 3.02
86 INT88273 Gene_expression of Drd4 6 0.54 1.84 3.01
87 INT12812 Regulation of Hrh3 10 0.51 1.07 2.95
88 INT82992 Gene_expression of DRD3 3 0.50 2.12 2.88
89 INT99419 Regulation of Drd3 7 0.48 1.89 2.81
90 INT147412 Binding of DRD4 11 0.47 7.57 2.77
91 INT104035 Gene_expression of LTB4R2 12 0.66 7.41 2.76
92 INT54495 Binding of GABBR1 9 0.35 1.82 2.76
93 INT119855 Localization of Gabbr1 21 0.79 3.15 2.7
94 INT189863 Gene_expression of DRD4 11 0.68 7.65 2.66
95 INT89327 Positive_regulation of Gene_expression of Drd3 4 0.54 0.32 2.64
96 INT89326 Transcription of Drd3 4 0.37 0.67 2.58
97 INT108468 Negative_regulation of Gene_expression of Drd2 3 0.41 0.67 2.58
98 INT88272 Gene_expression of Drd4 5 0.66 1.07 2.53
99 INT64062 Negative_regulation of Regulation of OPRM1 2 0.41 0.3 2.48
100 INT114773 Negative_regulation of GABBR1 4 0.43 0.55 2.33
101 INT51047 Regulation of Drd3 4 0.53 2 2.2
102 INT354232 Regulation of Gene_expression of P2ry12 1 0.26 2.47 2.19
103 INT103881 Positive_regulation of Binding of DRD2 4 0.69 2.01 2.18
104 INT105008 Binding of DRD3 5 0.36 3.15 2.05
105 INT58352 Negative_regulation of Gene_expression of Gabbr1 5 0.43 1.36 2.05
106 INT25411 Positive_regulation of Positive_regulation of Drd2 2 0.48 0.5 1.98
107 INT32980 Positive_regulation of Regulation of OPRM1 2 0.45 0 1.98
108 INT23426 Regulation of ADRA2A 8 0.48 1.81 1.88
109 INT6353 Positive_regulation of Positive_regulation of Gabbr1 2 0.46 0.79 1.85
110 INT178130 Binding of EDNRB 12 0.36 6.18 1.84
111 INT8489 Negative_regulation of Hrh3 5 0.38 1.01 1.83
112 INT142684 Protein_catabolism of OPRM1 2 0.66 0.48 1.81
113 INT89330 Positive_regulation of Binding of Drd3 1 0.31 0.16 1.81
114 INT122435 Positive_regulation of Grm7 3 0.00 1.89 1.79
115 INT79683 Negative_regulation of Grm7 3 0.41 2.22 1.75
116 INT267108 Negative_regulation of Gene_expression of DRD3 2 0.26 1.53 1.69
117 INT193415 Positive_regulation of GALR1 1 0.36 2.27 1.66
118 INT193416 Positive_regulation of GALR3 1 0.31 2.25 1.65
119 INT164544 Positive_regulation of Gene_expression of P2ry12 4 0.67 2.41 1.64
120 INT69820 Binding of Hrh3 6 0.37 0.89 1.58
121 INT138083 Positive_regulation of Gene_expression of Drd4 2 0.40 1.34 1.55
122 INT43327 Positive_regulation of ADRA2A 3 0.46 1.54 1.53
123 INT139514 Localization of EDNRB 7 0.73 4.63 1.52
124 INT47998 Positive_regulation of Hrh3 4 0.70 1.12 1.51
125 INT107376 Negative_regulation of P2ry12 12 0.43 4.39 1.5
126 INT75062 Regulation of Transcription of Drd2 1 0.51 0 1.41
127 INT55108 Negative_regulation of Negative_regulation of Gabbr1 1 0.02 0 1.35
128 INT79681 Localization of Grm7 5 0.78 2.57 1.34
129 INT115804 Regulation of Localization of OPRM1 2 0.33 0.12 1.33
130 INT112063 Regulation of Gene_expression of Drd3 2 0.09 1.84 1.31
131 INT69498 Positive_regulation of DRD4 3 0.50 0.95 1.3
132 INT67450 Negative_regulation of Localization of OPRM1 2 0.06 0.24 1.26
133 INT109272 Negative_regulation of Binding of DRD2 2 0.36 0.76 1.26
134 INT82991 Regulation of Gene_expression of DRD3 1 0.23 0.59 1.26
135 INT82988 Regulation of Transcription of DRD3 1 0.38 0.59 1.26
136 INT15663 Regulation of Transcription of Drd2 2 0.26 0.1 1.25
137 INT82987 Transcription of DRD3 1 0.58 0.59 1.25
138 INT130323 Regulation of Grm7 3 0.26 1.9 1.21
139 INT89328 Regulation of Transcription of Drd3 2 0.22 0.51 1.21
140 INT4570 Negative_regulation of Drd3 4 0.39 0.09 1.2
141 INT77216 Localization of DRD2 3 0.75 0 1.19
142 INT1867 Positive_regulation of GABBR1 6 0.69 0.55 1.18
143 INT69821 Negative_regulation of Hrh3 4 0.43 3.59 1.15
144 INT62959 Positive_regulation of CCR2 4 0.61 1.47 1.13
145 INT158242 Negative_regulation of Gene_expression of CCR2 3 0.37 2.13 1.12
146 INT35786 Negative_regulation of Negative_regulation of OPRM1 2 0.33 0.91 1.1
147 INT194657 Negative_regulation of CCR2 2 0.29 2.3 1.07
148 INT60441 Positive_regulation of Positive_regulation of Drd3 1 0.21 0 1.07
149 INT12976 Negative_regulation of ADRA2A 4 0.50 0.16 1.01
150 INT88083 Negative_regulation of Drd3 3 0.58 0.88 1.01
151 INT127052 Transcription of Drd3 2 0.37 0.06 1
152 INT202579 Regulation of Gene_expression of DRD2 4 0.41 1.11 0.99
153 INT82989 Regulation of DRD3 1 0.23 0.45 0.99
154 INT6355 Regulation of Positive_regulation of Gabbr1 1 0.27 0 0.96
155 INT78181 Negative_regulation of EDNRB 6 0.57 4.46 0.95
156 INT158378 Transcription of Grm7 1 0.00 0.65 0.94
157 INT139515 Positive_regulation of EDNRB 15 0.67 10.35 0.93
158 INT47997 Negative_regulation of Positive_regulation of Hrh3 2 0.38 0.91 0.89
159 INT89331 Positive_regulation of Transcription of Drd3 1 0.21 0.09 0.85
160 INT11086 Regulation of Positive_regulation of Drd2 2 0.45 1.22 0.84
161 INT119491 Positive_regulation of Positive_regulation of Drd3 1 0.46 0.17 0.83
162 INT88271 Positive_regulation of Drd4 2 0.19 0.5 0.82
163 INT13692 Negative_regulation of Positive_regulation of Drd2 1 0.01 0 0.79
164 INT103879 Regulation of Binding of DRD2 1 0.23 0.13 0.79
165 INT178127 Positive_regulation of Gene_expression of EDNRB 7 0.51 5.24 0.78
166 INT16434 Regulation of Positive_regulation of Drd2 1 0.30 0 0.78
167 INT18836 Localization of ADRA2A 2 0.38 0.33 0.76
168 INT148839 Regulation of Gene_expression of CCR2 2 0.26 1.78 0.76
169 INT152550 Regulation of Hrh3 2 0.45 1.17 0.75
170 INT148310 Regulation of Regulation of P2ry12 1 0.43 0.09 0.74
171 INT183250 Negative_regulation of Binding of P2ry12 2 0.16 0.98 0.73
172 INT117246 Transcription of GABBR1 1 0.38 0.07 0.72
173 INT148303 Localization of P2ry12 1 0.67 0.09 0.72
174 INT12885 Negative_regulation of Binding of Drd2 2 0.53 0.26 0.71
175 INT78351 Gene_expression of GALR1 2 0.77 1.03 0.7
176 INT91056 Negative_regulation of Gene_expression of Grm7 2 0.18 1.21 0.69
177 INT136269 Transcription of CCR2 2 0.61 1.27 0.69
178 INT326603 Regulation of Positive_regulation of DRD2 1 0.44 0.8 0.69
179 INT15662 Positive_regulation of Transcription of Drd2 3 0.39 0 0.68
180 INT354233 Positive_regulation of Regulation of P2ry12 1 0.45 0.33 0.68
181 INT345211 Positive_regulation of Grm7 1 0.02 0.64 0.66
182 INT184840 Positive_regulation of Transcription of Drd2 2 0.35 1.03 0.65
183 INT264628 Regulation of GABBR1 3 0.26 1.39 0.62
184 INT139513 Negative_regulation of Localization of EDNRB 2 0.41 0 0.62
185 INT127050 Positive_regulation of Transcription of Drd3 1 0.26 0.06 0.62
186 INT154199 Regulation of Localization of Grm7 1 0.60 0.92 0.62
187 INT77502 Regulation of GALR1 2 0.27 1.03 0.6
188 INT251386 Transcription of Gabbr1 4 0.68 0.22 0.58
189 INT120995 Positive_regulation of Gene_expression of Grm7 1 0.00 0.57 0.57
190 INT12483 Regulation of Binding of Drd2 1 0.38 0 0.57
191 INT47933 Positive_regulation of Localization of Drd2 1 0.10 0.23 0.56
192 INT135534 Regulation of Gene_expression of Drd4 1 0.30 0.18 0.56
193 INT47934 Negative_regulation of Localization of Drd2 1 0.10 0.22 0.56
194 INT75420 Regulation of Binding of Gabbr1 1 0.01 0 0.54
195 INT327693 Regulation of Palm 1 0.18 0 0.54
196 INT30428 Positive_regulation of Binding of ADRA2A 1 0.34 0.59 0.53
197 INT135979 Regulation of Gene_expression of GALR1 1 0.61 0.94 0.53
198 INT239551 Binding of CCR2 2 0.39 0 0.52
199 INT89285 Positive_regulation of Gene_expression of Drd3 2 0.60 0.09 0.52
200 INT156210 Regulation of Positive_regulation of Drd4 1 0.45 0.72 0.49
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