GO:0007196

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Name inhibition of adenylate cyclase activity by G-protein coupled glutamate receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0007196
Unique Molecular Interactions 51
Total Molecular Interactions 67
Total Single Events 697
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for inhibition of adenylate cyclase activity by G-protein coupled glutamate receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for inhibition of adenylate cyclase activity by G-protein coupled glutamate receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT156799 Gria1 Regulation of Grm8 1 0.11 1.29 2.45
2 INT154203 Binding of Pick1 and Grm7 1 0.41 1.64 1.28
3 INT195541 Lct Positive_regulation of Gene_expression of Grm2 1 0.02 0.4 1.27
4 INT110435 Positive_regulation of Grm8 Positive_regulation of Localization of Ca2 1 0.38 0 1.21
5 INT144062 Grm8 Regulation of Localization of Pag1 1 0.21 0.63 0.79
6 INT195545 Rel Regulation of Gene_expression of Grm3 1 0.01 0.46 0.71
7 INT160971 Gm2111 Positive_regulation of Grm7 1 0.01 0.16 0.41
8 INT349951 Grm7 Regulation of pcp 1 0.00 0.56 0.28
9 INT93260 Grm8 Regulation of Penk 1 0.08 0 0.28
10 INT241969 Grm8 Positive_regulation of Prkaca 1 0.05 0.35 0.27
11 INT91316 Binding of Grm2 and Vom1r93 1 0.00 0.16 0.26
12 INT241965 Prkaca Negative_regulation of Grm8 1 0.03 0.36 0.26
13 INT195544 Lct Positive_regulation of Transcription of Grm2 1 0.01 0.06 0.24
14 INT195547 Lct Positive_regulation of Transcription of Grm3 1 0.00 0.06 0.24
15 INT195553 Lct Positive_regulation of Grm2 1 0.02 0.05 0.23
16 INT195548 Lct Positive_regulation of Grm3 1 0.00 0.06 0.23
17 INT170721 Siah1a Regulation of Negative_regulation of Grm2 1 0.22 0 0.18
18 INT241967 Binding of Grm7 and Acpt 1 0.17 0 0.16
19 INT170724 Binding of Grm8 and Siah1a 1 0.19 0.11 0.15
20 INT241963 Prkaca Positive_regulation of Positive_regulation of Grm8 1 0.03 0 0.13
21 INT301041 Grm6 Regulation of Trpv1 1 0.00 0.06 0.1
22 INT277431 Positive_regulation of Grm3 Positive_regulation of Gene_expression of Gdnf 1 0.18 0 0.07
23 INT170722 Siah1a Regulation of Gene_expression of Grm8 1 0.24 0 0.07
24 INT195556 Smc2 Regulation of Gene_expression of Grm3 1 0.01 0 0.06
25 INT195550 Smc2 Regulation of Gene_expression of Grm2 1 0.02 0 0.06
26 INT195551 Lct Regulation of Gene_expression of Grm2 1 0.01 0 0.05
27 INT195546 Smc2 Regulation of Transcription of Grm2 1 0.02 0 0.03
28 INT195543 Smc2 Regulation of Transcription of Grm3 1 0.01 0 0.03
29 INT282504 Binding of Grik2 and Grik3 1 0.27 0.61 0
30 INT282507 Binding of Grik3 and ocd 1 0.25 0.61 0
31 INT170718 Siah1a Regulation of Grm8 1 0.24 0 0
32 INT195542 Smc2 Negative_regulation of Gene_expression of Grm2 1 0.02 0 0
33 INT301045 Binding of Csn2 and Grm6 1 0.02 0.51 0
34 INT195555 Smc2 Regulation of Grm2 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for inhibition of adenylate cyclase activity by G-protein coupled glutamate receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in inhibition of adenylate cyclase activity by G-protein coupled glutamate receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48536 Positive_regulation of Grm8 46 0.61 14.31 23.56
2 INT74745 Gene_expression of Grm8 30 0.68 9.85 14.52
3 INT102370 Positive_regulation of Grm2 10 0.45 5.03 10.9
4 INT145875 Gene_expression of Grm2 28 0.58 6.81 10.19
5 INT48088 Regulation of Grm8 12 0.62 4.93 8.71
6 INT69460 Positive_regulation of Grm2 12 0.49 6.54 8.18
7 INT73544 Gene_expression of Grm7 34 0.64 31.28 8.04
8 INT79682 Gene_expression of Grm7 6 0.75 4.74 4.5
9 INT145876 Regulation of Gene_expression of Grm2 3 0.00 2.4 4.46
10 INT195522 Gene_expression of Grm3 12 0.24 2.32 4.13
11 INT89516 Negative_regulation of Grm8 7 0.41 4.01 3.82
12 INT79680 Binding of Grm7 6 0.47 2.83 3.58
13 INT145873 Positive_regulation of Gene_expression of Grm2 3 0.26 3.44 3.45
14 INT97218 Regulation of Gene_expression of Grm8 3 0.24 2.26 2.97
15 INT144955 Binding of Grm8 8 0.22 1.82 2.83
16 INT163206 Transcription of Grm3 2 0.45 2.03 2.68
17 INT110735 Regulation of Positive_regulation of Grm8 3 0.40 1.19 2.62
18 INT91311 Gene_expression of Grm2 6 0.45 0.89 2.58
19 INT144956 Negative_regulation of Gene_expression of Grm8 7 0.29 2.53 2.5
20 INT195525 Regulation of Gene_expression of Grm3 1 0.04 0.82 2.14
21 INT122435 Positive_regulation of Grm7 3 0.00 1.89 1.79
22 INT79683 Negative_regulation of Grm7 3 0.41 2.22 1.75
23 INT195535 Positive_regulation of Grm3 8 0.25 3.37 1.67
24 INT102371 Positive_regulation of Gene_expression of Grm2 2 0.35 0.41 1.63
25 INT74746 Transcription of Grm8 5 0.45 0.45 1.48
26 INT195526 Positive_regulation of Transcription of Grm3 1 0.04 1.12 1.43
27 INT79681 Localization of Grm7 5 0.78 2.57 1.34
28 INT142288 Negative_regulation of Grm2 4 0.42 0.81 1.32
29 INT145874 Positive_regulation of Positive_regulation of Grm2 2 0.12 1.24 1.32
30 INT102369 Regulation of Positive_regulation of Grm2 1 0.11 0.54 1.27
31 INT130323 Regulation of Grm7 3 0.26 1.9 1.21
32 INT195524 Binding of Grm2 1 0.09 0.6 1.06
33 INT158378 Transcription of Grm7 1 0.00 0.65 0.94
34 INT91310 Negative_regulation of Gene_expression of Grm2 2 0.33 0.2 0.87
35 INT91309 Transcription of Grm2 4 0.69 1.57 0.86
36 INT170715 Regulation of Grm2 2 0.20 0.34 0.75
37 INT117047 Regulation of Positive_regulation of Grm2 1 0.00 0.46 0.74
38 INT170705 Localization of Grm8 4 0.33 0.34 0.69
39 INT91056 Negative_regulation of Gene_expression of Grm7 2 0.18 1.21 0.69
40 INT345211 Positive_regulation of Grm7 1 0.02 0.64 0.66
41 INT193557 Positive_regulation of Negative_regulation of Grm2 1 0.35 0 0.63
42 INT195521 Regulation of Grm2 2 0.07 0.51 0.62
43 INT154199 Regulation of Localization of Grm7 1 0.60 0.92 0.62
44 INT120995 Positive_regulation of Gene_expression of Grm7 1 0.00 0.57 0.57
45 INT48537 Positive_regulation of Positive_regulation of Grm8 3 0.28 0.43 0.52
46 INT201278 Gene_expression of Grik3 1 0.41 0.55 0.52
47 INT195520 Transcription of Grm2 1 0.17 0.06 0.47
48 INT304868 Localization of Grm2 1 0.32 0.09 0.44
49 INT195539 Negative_regulation of Grm2 2 0.41 0.09 0.43
50 INT158485 Gene_expression of Grm6 12 0.71 1.4 0.33
51 INT284758 Regulation of Grik3 1 0.17 0.07 0.33
52 INT223646 Regulation of Gene_expression of Grm7 1 0.01 4.41 0.32
53 INT195537 Regulation of Transcription of Grm3 1 0.02 0.08 0.31
54 INT241936 Negative_regulation of Positive_regulation of Grm8 1 0.21 0.11 0.31
55 INT193559 Negative_regulation of Binding of Grm8 1 0.27 0.07 0.26
56 INT195540 Regulation of Transcription of Grm2 1 0.07 0.05 0.24
57 INT93381 Regulation of Transcription of Grm8 1 0.21 0.17 0.22
58 INT223645 Positive_regulation of Gene_expression of Grm7 2 0.25 1.16 0.21
59 INT277417 Positive_regulation of Gene_expression of Grm3 2 0.18 0.55 0.17
60 INT266213 Positive_regulation of Grm6 2 0.46 1.88 0.16
61 INT241959 Binding of Grm7 1 0.23 0 0.15
62 INT301029 Localization of Grm6 1 0.16 1.15 0.14
63 INT260454 Localization of Grm2 1 0.17 0.11 0.13
64 INT260482 Localization of Grm7 1 0.18 0.11 0.13
65 INT335911 Positive_regulation of Positive_regulation of Grm3 1 0.01 0.39 0.1
66 INT195534 Binding of Grm3 1 0.13 0 0.1
67 INT301037 Regulation of Grm6 1 0.06 0.05 0.1
68 INT338884 Regulation of Grm7 1 0.13 0.42 0.09
69 INT338883 Positive_regulation of Regulation of Grm7 1 0.22 0.42 0.09
70 INT223654 Negative_regulation of Transcription of Grm2 1 0.41 0.65 0.08
71 INT209284 Positive_regulation of Gene_expression of Grm8 1 0.12 0.09 0.04
72 INT266197 Transcription of Grm6 2 0.55 0 0
73 INT170697 Positive_regulation of Protein_catabolism of Grm8 1 0.19 0.09 0
74 INT170690 Protein_catabolism of Grm8 1 0.40 0.19 0
75 INT101335 Binding of Grm2 1 0.02 0.16 0
76 INT195529 Negative_regulation of Gene_expression of Grm2 1 0.11 0 0
77 INT266198 Positive_regulation of Gene_expression of Grm6 1 0.46 0.34 0
78 INT282480 Binding of Grik3 1 0.39 0.61 0
79 INT195533 Negative_regulation of Grm3 1 0.04 0 0
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