GO:0007198

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Name inhibition of adenylate cyclase activity by serotonin receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0007198
Unique Molecular Interactions 58
Total Molecular Interactions 67
Total Single Events 794
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for inhibition of adenylate cyclase activity by serotonin receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for inhibition of adenylate cyclase activity by serotonin receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT121802 DEAF1 Negative_regulation of HTR1A 1 0.46 0.88 1.29
2 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
3 INT50889 Binding of HTR1A and HTR1D 2 0.40 0.31 1.05
4 INT137103 Sec22b Regulation of Htr1a 1 0.09 0 1.02
5 INT60208 Binding of Htr1a and Htr2c 2 0.52 0.25 1
6 INT69767 Binding of Htr1a and Ptgdr 1 0.23 0 0.97
7 INT161231 Positive_regulation of Htr1a Positive_regulation of Gene_expression of VEGFA 1 0.67 0.16 0.95
8 INT29279 Binding of Drd1a and Htr1a 1 0.35 0.2 0.84
9 INT79617 Htr1a Positive_regulation of Localization of POMC 1 0.38 0 0.83
10 INT70422 Binding of Htr1a and Adarb1 1 0.01 0.37 0.81
11 INT152867 HTR1A Negative_regulation of Localization of S100b 1 0.46 0 0.75
12 INT235604 Binding of Htr1a and Htr3a 1 0.01 0 0.74
13 INT137101 Fst Regulation of Htr1a 1 0.24 0 0.67
14 INT110407 Htr1a Positive_regulation of Gene_expression of Fos 1 0.50 0.52 0.66
15 INT137100 Dlst Regulation of Htr1a 1 0.18 0 0.64
16 INT236003 Binding of HTR1A and Grin1 1 0.01 0.7 0.63
17 INT159839 Binding of HTR1A and HTR7 1 0.39 0.38 0.62
18 INT159840 Binding of HTR1A and HTR6 1 0.39 0.38 0.62
19 INT181491 Tryptase Positive_regulation of HTR1A 1 0.02 0.93 0.61
20 INT70254 Binding of Htr1a and Ca2 1 0.31 0.5 0.6
21 INT64036 Binding of AVP and HTR1A 1 0.40 0.36 0.57
22 INT160156 Tph2 Regulation of Htr1a 1 0.30 0.75 0.56
23 INT235390 HTR1A Regulation of BGLAP 1 0.03 0.23 0.51
24 INT81004 Htr1a Positive_regulation of Gtpbp4 1 0.20 0 0.5
25 INT253896 Binding of Htr1a and Pag1 1 0.30 0.29 0.49
26 INT132580 Binding of ADRA2C and Htr1a 1 0.41 0.27 0.45
27 INT235389 Binding of BGLAP and HTR1A 1 0.03 0.15 0.45
28 INT118136 Binding of HTR1A and HTR2A 1 0.36 0.77 0.45
29 INT55395 Binding of Htr1a and Adra2a 1 0.42 0 0.43
30 INT77585 Binding of Htr1a and Ptprg 1 0.01 0 0.42
31 INT77584 Negative_regulation of Binding of Htr1a and Ptprg 1 0.01 0 0.42
32 INT53139 Binding of Htr1a and Kcnj3 1 0.37 0 0.42
33 INT79616 Htr1a Positive_regulation of Localization of Oxt 1 0.44 0 0.41
34 INT227568 NR3C1 Positive_regulation of HTR1A 1 0.00 0 0.4
35 INT79618 Htr1a Positive_regulation of POMC 1 0.17 0 0.39
36 INT79615 Htr1a Positive_regulation of Oxt 1 0.44 0 0.38
37 INT77587 Binding of HTR1A and Htr1a 1 0.05 0 0.38
38 INT79614 Negative_regulation of Htr1a Positive_regulation of Oxt 1 0.38 0 0.38
39 INT143166 C1orf61 Regulation of Transcription of HTR1A 1 0.30 0.51 0.35
40 INT71089 Binding of HTR1A and Pnoc 1 0.01 0 0.35
41 INT236006 HTR1A Regulation of Grin2b 1 0.00 0 0.33
42 INT222721 Binding of HTR1A and Pdpk1 1 0.00 0.35 0.33
43 INT353208 NEUROG2 Positive_regulation of Gene_expression of HTR1A 1 0.05 0.35 0.31
44 INT26235 Binding of GSR and Htr1a 1 0.12 0.09 0.31
45 INT292570 Binding of F2RL1 and HTR1A 1 0.07 0.8 0.28
46 INT122871 HTR1A Positive_regulation of MAPK1 1 0.56 0 0.2
47 INT41977 Binding of Htr1a and Dync1i2 1 0.02 0.54 0.18
48 INT41978 Binding of Agt and Htr1a 1 0.41 0.54 0.18
49 INT76196 Binding of HTR1A and EIF2B3 1 0.06 0 0.17
50 INT235984 HTR1A Negative_regulation of MAPK1 1 0.01 0 0.16
51 INT326605 Binding of HTR1A and KCNH2 1 0.00 0.45 0.14
52 INT189298 Atp6v1e1 Positive_regulation of Positive_regulation of Htr1a 1 0.00 1.15 0.11
53 INT68262 Binding of HTR1A and MTG1 1 0.39 0 0.1
54 INT206897 Binding of HTR1A and Adm 1 0.02 0.87 0.05
55 INT206900 Binding of HTR1A and Calca 1 0.01 0.88 0.05
56 INT76195 Binding of HTR1A and HTR1B 1 0.40 0 0.04
57 INT62419 Binding of Htr1a and Htr7 1 0.39 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for inhibition of adenylate cyclase activity by serotonin receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in inhibition of adenylate cyclase activity by serotonin receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6176 Positive_regulation of Htr1a 117 0.67 28.23 66.17
2 INT9039 Negative_regulation of Htr1a 69 0.57 9.56 41.84
3 INT6177 Binding of Htr1a 65 0.47 17.65 30.59
4 INT8122 Regulation of Htr1a 39 0.60 8.96 24.89
5 INT5916 Positive_regulation of HTR1A 51 0.67 18.27 21.38
6 INT7487 Gene_expression of Htr1a 36 0.75 11.08 20.05
7 INT13790 Binding of HTR1A 52 0.47 18.83 17.59
8 INT59365 Gene_expression of HTR1A 41 0.75 16.31 16.57
9 INT14131 Regulation of HTR1A 34 0.60 9.61 14.74
10 INT14132 Negative_regulation of HTR1A 25 0.57 4.93 10.91
11 INT7044 Positive_regulation of Positive_regulation of Htr1a 17 0.67 3.5 10
12 INT10208 Negative_regulation of Binding of Htr1a 18 0.57 13.98 8.91
13 INT34106 Negative_regulation of Htr1a 14 0.57 4.72 8.73
14 INT6228 Localization of Htr1a 14 0.78 0.46 6.2
15 INT59969 Positive_regulation of Htr1a 12 0.67 5.07 5.73
16 INT72336 Transcription of Htr1a 7 0.69 3.09 5.61
17 INT59718 Regulation of Htr1a 10 0.44 3.9 5.44
18 INT77583 Positive_regulation of Gene_expression of Htr1a 6 0.49 4.23 3.72
19 INT23026 Negative_regulation of Positive_regulation of Htr1a 9 0.42 0.42 3.69
20 INT160153 Gene_expression of Htr1a 7 0.65 2.95 3.23
21 INT41340 Binding of Htr1a 5 0.47 0.76 3.16
22 INT72322 Positive_regulation of Localization of Htr1a 5 0.49 0 3.08
23 INT66519 Positive_regulation of Binding of Htr1a 5 0.67 3.61 2.81
24 INT79080 Regulation of Positive_regulation of Htr1a 4 0.44 0.08 2.56
25 INT10667 Localization of HTR1A 4 0.78 1.43 2.03
26 INT83821 Regulation of Binding of Htr1a 3 0.60 0.69 2.02
27 INT331005 Regulation of Gene_expression of HTR1A 1 0.44 1.84 1.83
28 INT95961 Localization of Htr1a 3 0.78 1.5 1.66
29 INT77586 Positive_regulation of Gene_expression of HTR1A 6 0.46 3.54 1.51
30 INT72407 Regulation of Binding of HTR1A 4 0.48 0.99 1.47
31 INT71488 Transcription of HTR1A 2 0.69 0.7 1.36
32 INT115608 Negative_regulation of Gene_expression of Htr1a 4 0.57 1.19 1.32
33 INT71504 Negative_regulation of Negative_regulation of HTR1A 3 0.57 0.14 1.32
34 INT91784 Positive_regulation of Transcription of Htr1a 2 0.45 1.38 1.31
35 INT169161 Negative_regulation of Gene_expression of HTR1A 3 0.42 2.53 1.27
36 INT81002 Positive_regulation of Regulation of Htr1a 2 0.49 0.33 1.16
37 INT6306 Positive_regulation of Positive_regulation of HTR1A 3 0.64 0.48 1.15
38 INT81895 Regulation of Positive_regulation of HTR1A 2 0.44 1.37 1.04
39 INT91598 Positive_regulation of Localization of HTR1A 3 0.49 0.51 1.03
40 INT72583 Positive_regulation of Positive_regulation of Htr1a 1 0.00 0.56 0.97
41 INT18451 Positive_regulation of Binding of HTR1A 3 0.67 1.97 0.81
42 INT61310 Negative_regulation of Binding of HTR1A 2 0.57 1.36 0.72
43 INT136804 Positive_regulation of Negative_regulation of HTR1A 1 0.45 0.09 0.62
44 INT121803 Regulation of Negative_regulation of HTR1A 1 0.26 0.48 0.58
45 INT50587 Regulation of Localization of Htr1a 1 0.44 0 0.52
46 INT171476 Negative_regulation of Regulation of HTR1A 1 0.42 1.05 0.52
47 INT114286 Regulation of Regulation of Htr1a 1 0.44 0.33 0.49
48 INT166774 Regulation of Gene_expression of Htr1a 1 0.60 0.16 0.48
49 INT68550 Positive_regulation of Negative_regulation of Htr1a 1 0.49 0.4 0.44
50 INT340207 Regulation of Gene_expression of Htr1a 1 0.26 0.07 0.42
51 INT340201 Positive_regulation of Localization of Htr1a 1 0.49 0.34 0.38
52 INT95962 Regulation of Regulation of Htr1a 1 0.44 0.21 0.37
53 INT19138 Regulation of Negative_regulation of Htr1a 1 0.26 0.14 0.37
54 INT95963 Negative_regulation of Localization of Htr1a 1 0.42 0.17 0.36
55 INT143167 Regulation of Transcription of HTR1A 1 0.44 0.51 0.35
56 INT314520 Positive_regulation of Gene_expression of Htr1a 1 0.44 0.62 0.28
57 INT314516 Positive_regulation of Regulation of Htr1a 1 0.44 0.38 0.24
58 INT91599 Negative_regulation of Localization of HTR1A 1 0.41 0.09 0.23
59 INT189291 Negative_regulation of Negative_regulation of Htr1a 1 0.01 1.56 0.2
60 INT235998 Regulation of Regulation of HTR1A 1 0.01 0 0.13
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