GO:0007199

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Name G-protein signaling, coupled to cGMP nucleotide second messenger
Categary Process
Go Slim No
Go Link GO:0007199
Unique Molecular Interactions 305
Total Molecular Interactions 386
Total Single Events 5323
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for G-protein signaling, coupled to cGMP nucleotide second messenger. They are ordered first by their pain relevance and then by number of times they were reported for G-protein signaling, coupled to cGMP nucleotide second messenger. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05
2 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
3 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
4 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
5 INT88875 Ifng Positive_regulation of Transcription of Nos2 1 0.02 0.27 1.03
6 INT88887 IRF6 Positive_regulation of Transcription of Nos2 1 0.21 0.27 1.02
7 INT88874 Ifng Regulation of Nos2 1 0.01 0.26 1.01
8 INT88884 IRF6 Regulation of Nos2 1 0.12 0.26 1
9 INT88886 IRF6 Positive_regulation of Nos2 1 0.22 0.26 1
10 INT88888 Regulation of IRF6 Positive_regulation of Nos2 1 0.20 0.26 1
11 INT146579 Hba Negative_regulation of Gene_expression of Nos2 1 0.44 1.01 0.95
12 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
13 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
14 INT108687 Nfkb1 Regulation of Positive_regulation of Nos2 1 0.50 1.28 0.88
15 INT108686 Nfkb1 Regulation of Nos2 1 0.69 1.27 0.88
16 INT160412 Tat Positive_regulation of Transcription of Nos2 1 0.37 0.98 0.86
17 INT41862 Agtr2 Regulation of Cpe 1 0.00 0 0.84
18 INT41859 Agtr2 Regulation of Cck 1 0.00 0 0.84
19 INT41860 Agtr2 Regulation of Vip 1 0.02 0 0.84
20 INT102931 Nos3 Positive_regulation of Nos2 1 0.43 1.63 0.83
21 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
22 INT88885 IRF6 Positive_regulation of Gene_expression of Nos2 1 0.21 0.1 0.81
23 INT88878 Negative_regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.06 0.1 0.81
24 INT34458 AGT Negative_regulation of PENK 1 0.00 0 0.81
25 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8
26 INT101439 Cck Positive_regulation of Agtr2 1 0.24 0.33 0.8
27 INT168455 Sult1a1 Negative_regulation of Nos2 1 0.08 1.99 0.79
28 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
29 INT168456 Arr3 Positive_regulation of Nos2 1 0.21 1.98 0.79
30 INT132889 Nfkb1 Regulation of Gene_expression of Nos2 1 0.16 0.21 0.79
31 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
32 INT128815 Mapk14 Regulation of Gene_expression of Nos2 1 0.21 0.46 0.74
33 INT159593 Regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.38 0.46 0.74
34 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
35 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
36 INT187522 ATIC Negative_regulation of Gene_expression of Nos2 1 0.02 1.46 0.7
37 INT149983 Binding of Cpox and Nos2 1 0.30 0.54 0.69
38 INT220035 Nos1 Positive_regulation of Nos2 1 0.29 0.45 0.66
39 INT135829 Cat2 Regulation of Nos2 1 0.47 0 0.65
40 INT9824 Binding of Agtr2 and Bcl2a1a 1 0.16 0.24 0.64
41 INT113780 AGT Positive_regulation of Positive_regulation of Nfkb1 1 0.00 1.25 0.64
42 INT266489 Dcps Positive_regulation of Gene_expression of Nos2 1 0.06 3.43 0.63
43 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 0.19 0.37 0.61
44 INT128817 Ephb1 Negative_regulation of Gene_expression of Nos2 1 0.16 0.37 0.61
45 INT124831 Fbp1 Positive_regulation of Nos2 1 0.36 0.64 0.61
46 INT339072 Eae1 Positive_regulation of Gene_expression of Nos2 1 0.02 3.76 0.59
47 INT128810 Il1b Positive_regulation of Gene_expression of Nos2 1 0.04 0.31 0.59
48 INT143426 Positive_regulation of B4GALNT1 Negative_regulation of Gene_expression of Nos2 1 0.00 0.83 0.58
49 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57
50 INT151459 Olr1745 Negative_regulation of Gene_expression of Nos2 1 0.04 0.82 0.57
51 INT78588 Positive_regulation of Binding of Nfkb1 and Nos2 1 0.01 0.33 0.56
52 INT50883 Binding of AGTR2 and ALB 1 0.37 0.19 0.56
53 INT81546 TNF Positive_regulation of Gene_expression of Nos2 1 0.04 0.54 0.56
54 INT78587 Binding of Nfkb1 and Nos2 1 0.01 0.33 0.55
55 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
56 INT34459 AGT Negative_regulation of MBTPS1 1 0.01 0 0.54
57 INT132438 Binding of AGT and OXTR 1 0.08 1.03 0.53
58 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
59 INT78590 Nos2 Positive_regulation of PTGS1 2 0.00 0.85 0.5
60 INT19296 AGT Positive_regulation of Localization of AVP 1 0.38 0 0.5
61 INT21315 AGT Positive_regulation of Npy 1 0.03 0.15 0.5
62 INT132060 NBN Positive_regulation of Nos2 1 0.01 0.21 0.49
63 INT212806 Rngtt Negative_regulation of Gene_expression of Nos2 1 0.03 0.9 0.49
64 INT149652 Zfp36 Regulation of Nos2 1 0.09 0.42 0.47
65 INT314200 Positive_regulation of Binding of Nos2 and Tnf 1 0.42 0.34 0.46
66 INT314201 Binding of Nos2 and Tnf 1 0.31 0.33 0.46
67 INT342633 ACE Regulation of Gene_expression of AGT 1 0.01 0.14 0.46
68 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
69 INT116610 Positive_regulation of Lnpep Regulation of Nos2 1 0.16 0.62 0.44
70 INT116608 Lnpep Regulation of Nos2 1 0.14 0.62 0.44
71 INT148634 Abat Negative_regulation of Transcription of Nos2 1 0.19 0.52 0.44
72 INT114341 Agt Positive_regulation of AGT 3 0.01 1.15 0.43
73 INT345288 AGT Positive_regulation of Localization of CCL2 1 0.01 1.5 0.43
74 INT212809 Il6 Positive_regulation of Gene_expression of Nos2 1 0.08 0.75 0.43
75 INT212810 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.03 0.74 0.43
76 INT345291 AGT Positive_regulation of CCL2 1 0.01 1.39 0.43
77 INT116611 Lnpep Positive_regulation of Binding of Nos2 1 0.16 0.62 0.42
78 INT135972 Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.04 0.54 0.41
79 INT156438 Cpox Positive_regulation of Nos2 3 0.14 1.24 0.4
80 INT97789 Positive_regulation of Cnr1 Negative_regulation of Gene_expression of Nos2 1 0.12 0.23 0.4
81 INT187487 Cebpg Positive_regulation of Gene_expression of Nos2 1 0.03 0.38 0.4
82 INT182489 Gene_expression of AGTR2 Positive_regulation of Gene_expression of AGTR1 1 0.26 0.92 0.4
83 INT81300 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.02 0.38 0.39
84 INT61954 IFNA1 Positive_regulation of Nos2 1 0.05 0.46 0.38
85 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38
86 INT168426 RYBP Regulation of Nos2 1 0.01 0.4 0.36
87 INT168424 Ptger2 Regulation of Binding of Nos2 1 0.22 0.52 0.36
88 INT97790 Foxm1 Negative_regulation of Gene_expression of Nos2 1 0.03 0.16 0.36
89 INT152240 Nfasc Regulation of Gene_expression of Nos2 1 0.06 0.19 0.36
90 INT168423 Ptger2 Regulation of Nos2 1 0.13 0.52 0.36
91 INT89500 Nos2 Positive_regulation of Il6 1 0.04 1.07 0.35
92 INT187488 Positive_regulation of Ros1 Positive_regulation of Gene_expression of Nos2 1 0.01 0.88 0.35
93 INT230786 Binding of AGT and ACE 4 0.15 2.53 0.34
94 INT175319 Negative_regulation of Nos2 Negative_regulation of Positive_regulation of Pnlip 1 0.01 0.83 0.34
95 INT276214 Binding of Nos2 and Nfkb1 1 0.12 0.31 0.34
96 INT89505 Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
97 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34
98 INT110758 Tnfaip8 Positive_regulation of Positive_regulation of Nos2 1 0.14 0.88 0.34
99 INT276209 Negative_regulation of Binding of Nos2 and Nfkb1 1 0.14 0.31 0.34
100 INT303126 Nos2 Positive_regulation of Gene_expression of Il6 1 0.13 4.38 0.34
101 INT89502 Positive_regulation of Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
102 INT110761 Tnfaip8 Positive_regulation of Nos2 1 0.13 0.88 0.34
103 INT72445 Binding of AGT and REN 3 0.34 0.88 0.31
104 INT115261 Gene_expression of Nos2 Positive_regulation of Positive_regulation of Npr1 1 0.05 0.67 0.31
105 INT354821 Nos2 Positive_regulation of Eif2ak2 1 0.06 0.64 0.3
106 INT230752 Gene_expression of Agtr2 Positive_regulation of Gene_expression of Mcpt1 1 0.01 1.34 0.3
107 INT200640 Agtr2 Positive_regulation of Gene_expression of TGFB1 1 0.03 1.35 0.29
108 INT333886 Binding of Lep and Positive_regulation of Gene_expression of Nos2 1 0.39 0.73 0.29
109 INT118545 Binding of Agtr2 and Msr1 1 0.00 0.09 0.29
110 INT200631 AGT Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
111 INT182499 Binding of AGTR1 and AGTR2 3 0.20 2.79 0.28
112 INT288911 AGT Positive_regulation of CYBB 3 0.07 2.96 0.28
113 INT228530 Gopc Positive_regulation of Gene_expression of Nos2 2 0.22 0.67 0.28
114 INT156439 Positive_regulation of Cpox Positive_regulation of Nos2 1 0.14 0.52 0.28
115 INT349506 S100a8 Positive_regulation of Gene_expression of Nos2 1 0.02 0.67 0.28
116 INT114066 Agtr2 Regulation of Gene_expression of Cpox 1 0.08 0.62 0.27
117 INT131357 Agtr2 Regulation of Ren 1 0.04 0.88 0.27
118 INT114069 Negative_regulation of Agtr2 Positive_regulation of Ptgs2 1 0.08 0.49 0.26
119 INT71309 Il1a Positive_regulation of Nos2 1 0.21 0.26 0.26
120 INT314305 Ptger2 Positive_regulation of Nos2 1 0.00 0.07 0.26
121 INT342456 AGT Positive_regulation of Gene_expression of CCL2 1 0.07 0.63 0.25
122 INT297258 Binding of Agt and Agtr2 1 0.23 0.7 0.25
123 INT41588 Binding of AGT and Lhb 1 0.00 0 0.24
124 INT41589 Binding of AGT and Prl 1 0.00 0 0.24
125 INT127101 Memo1 Negative_regulation of Gene_expression of Nos2 1 0.10 0.55 0.24
126 INT327321 Binding of Elavl1 and Nos2 1 0.05 0.6 0.24
127 INT327320 Positive_regulation of Binding of Elavl1 and Nos2 1 0.06 0.6 0.24
128 INT230748 Agtr2 Positive_regulation of Gene_expression of Ros1 2 0.05 1.04 0.23
129 INT191492 Binding of AGT and NLRP3 1 0.01 0.35 0.23
130 INT331767 Hand1 Positive_regulation of Nos2 1 0.08 0.48 0.23
131 INT273055 Plat Positive_regulation of Gene_expression of Nos2 1 0.01 1.34 0.23
132 INT230751 Agtr2 Positive_regulation of Gene_expression of Serpine1 1 0.03 1.3 0.23
133 INT132382 Nos2 Positive_regulation of PTGS2 1 0.02 0.1 0.23
134 INT201273 Nos2 Regulation of Nos1 1 0.17 0.99 0.23
135 INT133163 Nos2 Regulation of Tnf 1 0.36 0.97 0.22
136 INT155158 Agtr2 Regulation of Rtn4 1 0.00 0.1 0.22
137 INT159351 Negative_regulation of Binding of Nos1 and Nos2 1 0.27 0.34 0.22
138 INT104846 TNF Positive_regulation of Nos2 1 0.10 0.83 0.22
139 INT333397 CFD Negative_regulation of Gene_expression of Nos2 1 0.04 0.8 0.22
140 INT159348 Binding of Nos1 and Nos2 1 0.23 0.29 0.22
141 INT297257 Agtr1a Positive_regulation of Agtr2 1 0.27 0.59 0.22
142 INT281351 Tenc1 Regulation of Agtr2 1 0.06 0.8 0.21
143 INT159350 Zfp956 Negative_regulation of Nos2 1 0.03 0.3 0.21
144 INT183644 Nos2 Positive_regulation of Gene_expression of Macf1 1 0.05 0.84 0.21
145 INT304882 Agtr2 Positive_regulation of Mapk1 1 0.07 0.95 0.2
146 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2
147 INT258017 Binding of AGT and ANGPT2 3 0.11 2.35 0.19
148 INT222568 Vip Negative_regulation of Transcription of Nos2 1 0.06 0.3 0.19
149 INT222473 Mzb1 Negative_regulation of Transcription of Nos2 1 0.04 0.29 0.19
150 INT81302 Tlr4 Negative_regulation of Gene_expression of Nos2 1 0.02 0.18 0.18
151 INT81298 Ifng Negative_regulation of Gene_expression of Nos2 1 0.40 0.18 0.18
152 INT135973 Dpys Negative_regulation of Gene_expression of Nos2 1 0.06 0.26 0.17
153 INT229223 Binding of AGT and FAS 1 0.08 0.91 0.17
154 INT36568 AGT Positive_regulation of FBF1 1 0.39 0.5 0.17
155 INT135974 S100a4 Negative_regulation of Nos2 1 0.00 0.26 0.17
156 INT81297 Positive_regulation of Pparg Regulation of Gene_expression of Nos2 1 0.23 0.17 0.17
157 INT135971 S100a4 Negative_regulation of Gene_expression of Nos2 1 0.00 0.26 0.17
158 INT85334 Agtr2 Regulation of Regulation of Tgfb1 1 0.23 0.68 0.17
159 INT119130 Binding of Nos2 and Ptgs2 1 0.33 0.07 0.17
160 INT331766 Binding of Arg1 and Nos2 1 0.17 0.6 0.17
161 INT233904 NLRP3 Positive_regulation of AGT 1 0.06 0.81 0.17
162 INT320883 Agtr2 Positive_regulation of Localization of VEGFA 1 0.08 2.8 0.17
163 INT229224 Positive_regulation of Binding of AGT and FAS 1 0.09 0.92 0.17
164 INT135970 Dpys Negative_regulation of Nos2 1 0.05 0.25 0.17
165 INT344832 Hmgb1 Positive_regulation of Gene_expression of Nos2 1 0.12 0.82 0.17
166 INT36567 Negative_regulation of AGT Positive_regulation of FBF1 1 0.36 0.5 0.17
167 INT111863 Negative_regulation of Binding of AGT and LNPEP 1 0.09 0 0.16
168 INT290670 Binding of Nos2 and Ppara 1 0.17 0.41 0.16
169 INT261577 Nos2 Negative_regulation of Gene_expression of Il6 1 0.01 1 0.16
170 INT303122 Nos2 Positive_regulation of Gene_expression of Gpt 1 0.37 1.86 0.16
171 INT111861 Binding of AGT and LNPEP 1 0.07 0 0.16
172 INT303129 Nos2 Positive_regulation of Gene_expression of Gpt 1 0.17 1.86 0.16
173 INT199105 Decr1 Positive_regulation of Positive_regulation of Nos2 1 0.01 0.23 0.16
174 INT94864 Regulation of Litaf Positive_regulation of Nos2 1 0.05 0.05 0.15
175 INT94865 Litaf Positive_regulation of Nos2 1 0.08 0.05 0.15
176 INT138305 Binding of PNN and Agtr2 1 0.01 0.73 0.15
177 INT303128 Tnrc6a Regulation of Gene_expression of Nos2 1 0.00 0.57 0.14
178 INT347071 Negative_regulation of REN Negative_regulation of Positive_regulation of AGT 1 0.35 0.44 0.14
179 INT34430 AGT Positive_regulation of Localization of POMC 1 0.30 0.31 0.14
180 INT170817 CMA1 Positive_regulation of Gene_expression of AGT 1 0.19 1.41 0.14
181 INT344946 AGT Regulation of Negative_regulation of ACE 1 0.21 0.61 0.14
182 INT139343 Il1b Positive_regulation of Nos2 1 0.09 1.26 0.14
183 INT256020 Ace Negative_regulation of Gene_expression of Agtr2 1 0.03 0.37 0.13
184 INT194975 Negative_regulation of Alox5 Negative_regulation of Gene_expression of Nos2 1 0.13 0.69 0.13
185 INT59808 Binding of AGT and PLCB1 1 0.02 0 0.13
186 INT59809 AGT Positive_regulation of PLCB1 1 0.03 0 0.13
187 INT59810 ADRA1D Positive_regulation of AGT 1 0.01 0 0.13
188 INT347065 Binding of Gnat2 and Rho 1 0.14 0 0.12
189 INT304188 Agtr2 Negative_regulation of Gene_expression of VEGFA 1 0.06 0.6 0.12
190 INT194976 Alox5 Regulation of Gene_expression of Nos2 1 0.07 0.56 0.12
191 INT329325 ACE Regulation of Negative_regulation of Agtr2 1 0.01 0.93 0.12
192 INT182496 AGT Positive_regulation of Phosphorylation of STAT3 1 0.03 0.79 0.12
193 INT345290 AGT Positive_regulation of NOX1 1 0.00 1.11 0.12
194 INT156588 Hst1 Positive_regulation of Gene_expression of Nos2 1 0.27 0.48 0.12
195 INT119158 Binding of NOS1 and Agtr2 1 0.01 0 0.11
196 INT119157 Agt Positive_regulation of Positive_regulation of Agtr2 1 0.06 0 0.11
197 INT352497 AGT Positive_regulation of Binding of CRS 1 0.14 0.87 0.11
198 INT281905 Binding of AGTR2 and NOS3 1 0.08 0.37 0.1
199 INT151423 Tfrc Positive_regulation of Gene_expression of Nos2 1 0.24 0.49 0.1
200 INT334893 ACE Negative_regulation of Gene_expression of AGT 1 0.03 1.41 0.1

Single Events

The table below shows the top 100 pain related interactions that have been reported for G-protein signaling, coupled to cGMP nucleotide second messenger. They are ordered first by their pain relevance and then by number of times they were reported in G-protein signaling, coupled to cGMP nucleotide second messenger. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08
2 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07
3 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87
4 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43
5 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53
6 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15
7 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67
8 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65
9 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94
10 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82
11 INT61953 Transcription of Nos2 101 0.72 46.64 25.49
12 INT89854 Regulation of Nos2 49 0.61 42.58 24.1
13 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01
14 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
15 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
16 INT66281 Transcription of Nos2 81 0.71 39.49 20.37
17 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
18 INT61949 Regulation of Nos2 74 0.58 34.08 16.7
19 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33
20 INT3962 Regulation of AGT 50 0.62 20.96 13.01
21 INT97381 Negative_regulation of Positive_regulation of Nos2 34 0.59 16.66 11.6
22 INT398 Localization of AGT 45 0.78 16.97 11.54
23 INT48956 Negative_regulation of Positive_regulation of Nos2 34 0.46 13.15 11.15
24 INT8065 Binding of AGT 54 0.48 20.54 10.85
25 INT13499 Gene_expression of Agtr2 68 0.76 35.64 10.59
26 INT70850 Positive_regulation of Transcription of Nos2 30 0.70 18.95 9.68
27 INT116605 Binding of Nos2 28 0.37 16.88 8.18
28 INT72337 Positive_regulation of Positive_regulation of Nos2 37 0.65 17.02 8.11
29 INT112191 Positive_regulation of Transcription of Nos2 22 0.66 12.4 7.74
30 INT85751 Positive_regulation of Positive_regulation of Nos2 40 0.60 23.53 7.72
31 INT29583 Positive_regulation of Agtr2 30 0.45 21.47 7.04
32 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14
33 INT112190 Regulation of Negative_regulation of Nos2 8 0.62 5.83 5.09
34 INT73608 Localization of Nos2 21 0.75 9.58 5.05
35 INT61950 Regulation of Positive_regulation of Nos2 17 0.43 9.01 4.87
36 INT127914 Gene_expression of AGTR2 23 0.68 26.87 4.69
37 INT78995 Negative_regulation of Agtr2 26 0.42 13.05 4.56
38 INT17818 Gene_expression of Agtr2 24 0.56 12.96 4.41
39 INT3332 Protein_catabolism of AGT 23 0.87 3.17 4.39
40 INT89784 Regulation of Transcription of Nos2 14 0.42 8.39 4.24
41 INT68099 Positive_regulation of Agtr2 21 0.48 16.63 4.07
42 INT9822 Binding of Agtr2 9 0.36 3 3.93
43 INT17819 Regulation of Agtr2 10 0.51 9.33 3.9
44 INT39986 Regulation of Agtr2 13 0.45 10.39 3.55
45 INT61952 Negative_regulation of Transcription of Nos2 17 0.54 5.1 3.34
46 INT126223 Binding of Nos2 17 0.37 6 3.22
47 INT116235 Negative_regulation of Transcription of Nos2 23 0.58 7.91 3.14
48 INT31925 Negative_regulation of Agtr2 13 0.43 7.59 2.94
49 INT85750 Regulation of Positive_regulation of Nos2 10 0.54 7.78 2.83
50 INT72757 Negative_regulation of Negative_regulation of Nos2 8 0.42 4.23 2.68
51 INT89852 Localization of Nos2 22 0.78 14.89 2.56
52 INT17857 Negative_regulation of Gene_expression of AGT 25 0.46 21.16 2.45
53 INT79609 Positive_regulation of Negative_regulation of Nos2 5 0.49 3.6 2.43
54 INT27988 Negative_regulation of Positive_regulation of AGT 11 0.42 5.71 2.27
55 INT49731 Transcription of Agtr2 4 0.44 0.95 2.06
56 INT53036 Binding of Agtr2 9 0.33 3.74 1.99
57 INT112668 Positive_regulation of Gene_expression of Agtr2 7 0.50 3.8 1.58
58 INT181574 Phosphorylation of Nos2 9 0.70 2.92 1.55
59 INT68100 Positive_regulation of Positive_regulation of Agtr2 2 0.08 0.83 1.51
60 INT34768 Negative_regulation of Negative_regulation of AGT 10 0.25 2.79 1.42
61 INT8067 Negative_regulation of Binding of AGT 12 0.25 10.33 1.39
62 INT61951 Regulation of Negative_regulation of Nos2 5 0.58 3.08 1.39
63 INT44147 Positive_regulation of Gene_expression of Agtr2 11 0.50 9.02 1.28
64 INT11241 Transcription of AGT 4 0.52 1.83 1.27
65 INT144392 Negative_regulation of Negative_regulation of Nos2 2 0.42 1.83 1.24
66 INT47644 Positive_regulation of Localization of AGT 4 0.45 1.24 1.2
67 INT115621 Positive_regulation of Binding of AGT 1 0.02 0 1.15
68 INT61100 Localization of Agtr2 7 0.51 2.53 1.13
69 INT182513 Regulation of AGTR2 4 0.14 4.31 0.91
70 INT89856 Positive_regulation of Localization of Nos2 6 0.49 1.79 0.9
71 INT92836 Regulation of Transcription of Nos2 3 0.58 1.79 0.85
72 INT21943 Positive_regulation of Positive_regulation of AGT 6 0.46 3.29 0.75
73 INT34715 Regulation of Regulation of AGT 2 0.37 0.96 0.75
74 INT137080 Positive_regulation of Positive_regulation of Agtr2 3 0.26 2.34 0.74
75 INT137081 Positive_regulation of Regulation of Agtr2 1 0.24 0.54 0.72
76 INT103886 Negative_regulation of Negative_regulation of Agtr2 5 0.31 2.16 0.71
77 INT85023 Negative_regulation of Gene_expression of Agtr2 4 0.57 2.97 0.71
78 INT141062 Negative_regulation of Gene_expression of Agtr2 2 0.18 1.61 0.7
79 INT34769 Regulation of Gene_expression of AGT 3 0.19 1.39 0.67
80 INT112666 Positive_regulation of Transcription of Agtr2 1 0.32 0.74 0.65
81 INT96037 Positive_regulation of Localization of Nos2 2 0.49 0.78 0.52
82 INT233916 Positive_regulation of AGTR2 5 0.37 3.67 0.51
83 INT349037 Regulation of Phosphorylation of Nos2 1 0.39 1.02 0.51
84 INT229773 Positive_regulation of Regulation of Nos2 3 0.41 2.97 0.5
85 INT47645 Negative_regulation of Localization of AGT 2 0.11 1.09 0.49
86 INT108735 Regulation of Localization of Nos2 3 0.42 0.52 0.46
87 INT182508 Positive_regulation of Gene_expression of AGTR2 1 0.26 3.13 0.46
88 INT33017 Negative_regulation of Protein_catabolism of AGT 3 0.37 0 0.42
89 INT186288 Negative_regulation of Binding of Nos2 3 0.35 1.08 0.42
90 INT149650 Protein_catabolism of Nos2 3 0.55 0.79 0.42
91 INT208368 Negative_regulation of Regulation of Nos2 1 0.42 0.35 0.42
92 INT235457 Negative_regulation of Regulation of Nos2 3 0.42 1.55 0.39
93 INT182510 Negative_regulation of Gene_expression of AGTR2 1 0.23 0.78 0.37
94 INT95605 Regulation of Binding of AGT 3 0.44 0.2 0.34
95 INT126578 Regulation of Gene_expression of Agtr2 2 0.49 1.08 0.34
96 INT27928 Phosphorylation of AGT 1 0.52 0.15 0.34
97 INT27929 Negative_regulation of Phosphorylation of AGT 1 0.27 0.15 0.34
98 INT356392 Negative_regulation of Positive_regulation of Agtr2 1 0.07 1.01 0.32
99 INT106275 Regulation of Localization of Nos2 1 0.25 0.38 0.32
100 INT182515 Binding of AGTR2 3 0.32 2.4 0.29
101 INT182509 Regulation of Gene_expression of AGTR2 1 0.24 1.72 0.29
102 INT132377 Negative_regulation of Binding of Nos2 5 0.29 0.75 0.28
103 INT3331 Positive_regulation of Protein_catabolism of AGT 1 0.33 0 0.27
104 INT136741 Protein_catabolism of Agtr2 1 0.07 0 0.26
105 INT117878 Positive_regulation of Regulation of Nos2 3 0.41 1.35 0.25
106 INT124200 Negative_regulation of Localization of Nos2 1 0.22 0.7 0.25
107 INT227750 Positive_regulation of Binding of Nos2 1 0.18 0.8 0.23
108 INT242141 Gene_expression of Fzd1 1 0.21 2.5 0.21
109 INT209345 Negative_regulation of AGTR2 5 0.17 4.83 0.2
110 INT31926 Negative_regulation of Negative_regulation of Agtr2 1 0.00 0.19 0.2
111 INT17822 Regulation of Gene_expression of Agtr2 1 0.05 0.1 0.18
112 INT268208 Transcription of Agtr2 1 0.05 3.15 0.17
113 INT326469 Positive_regulation of Negative_regulation of AGTR2 1 0.09 2.96 0.16
114 INT183632 Phosphorylation of Nos2 3 0.61 0.79 0.15
115 INT236359 Negative_regulation of Positive_regulation of Agtr2 2 0.07 1.61 0.15
116 INT347057 Gene_expression of Gnat2 1 0.58 0.05 0.14
117 INT241008 Phosphorylation of Agtr2 1 0.09 0.13 0.14
118 INT161414 Negative_regulation of Localization of Nos2 2 0.30 0.9 0.13
119 INT214619 Positive_regulation of Negative_regulation of AGT 1 0.04 0.98 0.13
120 INT356371 Localization of Agtr2 1 0.04 0.74 0.11
121 INT143360 Regulation of Negative_regulation of Agtr2 1 0.27 0.56 0.1
122 INT50849 Negative_regulation of Regulation of AGT 2 0.42 1.26 0.08
123 INT291956 Positive_regulation of Negative_regulation of Nos2 1 0.41 0.54 0.08
124 INT233462 Regulation of Fzd1 1 0.45 0.33 0.08
125 INT288915 Regulation of Positive_regulation of AGT 1 0.41 0.82 0.08
126 INT288913 Regulation of Positive_regulation of AGTR2 1 0.28 0.43 0.06
127 INT347059 Regulation of Gnat2 1 0.26 0 0.05
128 INT347119 Localization of FZD1 1 0.68 0.16 0.03
129 INT349470 Regulation of Binding of Nos2 1 0.35 0 0
130 INT149640 Regulation of Protein_catabolism of Nos2 1 0.23 0 0
131 INT240985 Positive_regulation of Binding of Agtr2 1 0.07 0.83 0
132 INT109125 Positive_regulation of Protein_catabolism of Nos2 1 0.39 0 0
133 INT103887 Positive_regulation of Negative_regulation of Agtr2 1 0.08 0.1 0
134 INT242143 Regulation of Gene_expression of Fzd1 1 0.14 0.25 0
135 INT240996 Protein_catabolism of Agtr2 1 0.12 0.18 0
136 INT233478 Negative_regulation of Fzd1 1 0.31 0.09 0
137 INT109126 Protein_catabolism of Nos2 1 0.55 0 0
138 INT240990 Positive_regulation of Protein_catabolism of Agtr2 1 0.07 0.18 0
139 INT241016 Negative_regulation of Protein_catabolism of Agtr2 1 0.06 0.18 0
140 INT201624 Regulation of FZD1 1 0.01 0 0
141 INT242126 Positive_regulation of Fzd1 1 0.16 0.25 0
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