GO:0007200

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Name activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
Categary Process
Go Slim No
Go Link GO:0007200
Unique Molecular Interactions 816
Total Molecular Interactions 1109
Total Single Events 9627
Pain Genes Associated 49

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger. They are ordered first by their pain relevance and then by number of times they were reported for activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
2 INT21276 Binding of Oprd1 and Penk 9 0.54 1.14 8.28
3 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8
4 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
5 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 0.30 0.91 4.18
6 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16
7 INT249566 Binding of Oprd1 and Psmd1 1 0.01 0.82 3.8
8 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
9 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
10 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
11 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52
12 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
13 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 3 0.00 0.63 3.1
14 INT137230 Trh Regulation of Gene_expression of Oprd1 1 0.01 1.62 2.75
15 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
16 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59
17 INT69665 Binding of Oprd1 and Pnoc 5 0.35 0.4 2.5
18 INT249567 Positive_regulation of Binding of Oprd1 and Psmd1 1 0.01 0.66 2.5
19 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
20 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
21 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
22 INT5486 Oprd1 Regulation of Cck 1 0.21 0 2.16
23 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
24 INT133946 Binding of DNM2 and OPRK1 1 0.11 0 2.1
25 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
26 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
27 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
28 INT68272 Binding of Oprd1 and G2e3 1 0.00 0.11 1.93
29 INT6931 Binding of Oprk1 and Pdyn 2 0.24 0.92 1.92
30 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
31 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
32 INT119917 Zfp821 Positive_regulation of Positive_regulation of Oprd1 1 0.01 0 1.82
33 INT70225 oh Regulation of Oprd1 1 0.20 0.13 1.8
34 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
35 INT167319 Binding of OPRM1 and PCSK2 1 0.22 0.63 1.77
36 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
37 INT167321 Binding of ENG and OPRM1 1 0.27 0.63 1.76
38 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
39 INT129953 Oprd1 Regulation of Cspg5 1 0.17 0.15 1.74
40 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
41 INT37840 Binding of Cyp27b1 and Oprd1 1 0.01 0 1.73
42 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69
43 INT103725 Negative_regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.17 0.38 1.65
44 INT134742 Binding of OPRM1 and SV2A 1 0.33 0.18 1.64
45 INT103726 Regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.10 0.38 1.64
46 INT199490 Penk Positive_regulation of Oprk1 1 0.03 0.87 1.64
47 INT61049 Binding of Oprd1 and Negative_regulation of Gene_expression of Odc1 1 0.21 0 1.64
48 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
49 INT61674 Gpm6a Regulation of Oprd1 1 0.01 0.07 1.62
50 INT195930 OPRM1 Regulation of Prkaca 1 0.01 0 1.59
51 INT66408 Pomc Positive_regulation of Regulation of HRH1 1 0.01 0 1.58
52 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
53 INT116093 OPRM1 Positive_regulation of Positive_regulation of NFKB1 1 0.36 0.08 1.56
54 INT8734 Pebp1 Positive_regulation of Oprd1 1 0.01 0 1.54
55 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5
56 INT155497 Oprk1 Negative_regulation of Tenc1 1 0.08 0.34 1.48
57 INT116094 Binding of TACR1 and TFF2 1 0.06 0 1.47
58 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47
59 INT317509 Oprm1 Negative_regulation of Phosphorylation of Oprd1 1 0.00 0 1.46
60 INT141676 OPRM1 Positive_regulation of Ltp 1 0.04 0 1.46
61 INT141675 OPRM1 Positive_regulation of Negative_regulation of Ltp 1 0.04 0 1.46
62 INT83416 Binding of OPRK1 and Ntrk1 1 0.02 0 1.45
63 INT161858 OPRM1 Positive_regulation of GRIN1 1 0.50 0.12 1.45
64 INT128915 PENK Regulation of Gene_expression of OPRM1 1 0.22 0.07 1.43
65 INT96796 ITIH4 Regulation of Gene_expression of OPRM1 2 0.20 0.89 1.41
66 INT329451 Binding of Oprd1 and Tacr1 1 0.05 0.23 1.41
67 INT142852 Oprm1 Positive_regulation of Oprd1 1 0.41 0.06 1.41
68 INT266811 Binding of HRH1 and HTR2C 1 0.23 2.06 1.4
69 INT329452 Binding of Tac1 and Oprd1 1 0.01 0.23 1.4
70 INT133937 Binding of OPRK1 and ARFGEF1 1 0.01 0 1.39
71 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
72 INT6466 Binding of Npr1 and Oprd1 1 0.01 0 1.37
73 INT51203 Binding of OPRK1 and OPRM1 2 0.29 0.3 1.36
74 INT160590 CSF2 Positive_regulation of Gene_expression of OPRM1 1 0.16 0.54 1.35
75 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
76 INT160588 TNF Positive_regulation of Gene_expression of OPRM1 1 0.20 0.54 1.35
77 INT160587 IFNG Positive_regulation of Gene_expression of OPRM1 1 0.18 0.54 1.35
78 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
79 INT160589 IL4 Positive_regulation of Gene_expression of OPRM1 1 0.13 0.54 1.35
80 INT356317 Crhr1 Regulation of Gene_expression of Cea 1 0.18 0.65 1.33
81 INT249565 Binding of Gabrg1 and Oprd1 1 0.00 0.1 1.33
82 INT126831 Binding of Oprk1 and Rbm39 1 0.05 0.88 1.33
83 INT356326 Crhr1 Regulation of Gene_expression of Helt 1 0.01 0.65 1.32
84 INT13756 Binding of Oprd1 and Scn4a 1 0.02 0 1.32
85 INT13755 Binding of Oprd1 and Ap2m1 1 0.20 0 1.32
86 INT51200 Binding of OPRM1 and PENK 2 0.17 0.23 1.31
87 INT147653 TACR1 Positive_regulation of TRPV1 1 0.02 0.72 1.29
88 INT57263 Binding of Oprd1 and Atxn2l 1 0.02 0 1.29
89 INT57262 Binding of Gria4 and Oprd1 1 0.06 0 1.29
90 INT195929 Binding of OPRM1 and Prkaca 1 0.02 0.33 1.27
91 INT34393 Oprd1 Negative_regulation of Adcy1 1 0.36 0 1.27
92 INT67383 Binding of OPRK1 and Pdyn 2 0.00 0 1.25
93 INT110542 SIGMAR1 Regulation of OPRM1 1 0.04 0.33 1.25
94 INT110543 SIGMAR1 Regulation of Gene_expression of OPRM1 1 0.04 0.33 1.25
95 INT254210 Binding of Cxcr2 and Ccl2 1 0.08 2.39 1.25
96 INT88635 Ptger3 Positive_regulation of Localization of Calca 2 0.05 0 1.24
97 INT167278 Binding of OPRM1 and REST 1 0.08 0.94 1.24
98 INT63864 Oprd1 Regulation of Localization of Prl 2 0.16 0 1.23
99 INT150595 Binding of Oprk1 and Insrr 1 0.01 0.07 1.23
100 INT240095 Binding of PDYN and Oprk1 1 0.52 1.3 1.22
101 INT200455 OPRK1 Positive_regulation of Gene_expression of CCL2 1 0.19 0.07 1.21
102 INT113242 TNF Regulation of Transcription of OPRM1 2 0.45 1.53 1.19
103 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
104 INT13203 Oprd1 Negative_regulation of Akr1d1 1 0.01 0 1.18
105 INT49956 OPRM1 Positive_regulation of SGCG 1 0.53 0.3 1.18
106 INT13205 Oprd1 Negative_regulation of Npr1 2 0.01 0 1.16
107 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
108 INT137144 ITIH4 Regulation of OPRM1 1 0.20 1.13 1.16
109 INT125696 Binding of OPRM1 and SNRNP70 1 0.06 0.99 1.15
110 INT326665 Cpe Positive_regulation of Oprd1 1 0.01 1.24 1.15
111 INT199493 Ngf Regulation of Oprd1 1 0.05 1.05 1.15
112 INT339331 Binding of TACR1 and SFTPA1 1 0.04 0.12 1.14
113 INT110522 Oprm1 Positive_regulation of Oprk1 1 0.11 0 1.12
114 INT221183 Binding of OPRM1 and Mors1 1 0.00 0 1.12
115 INT21267 Cck Negative_regulation of Binding of Oprd1 1 0.50 0 1.12
116 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
117 INT69338 Binding of Oprd1 and Oprm1 1 0.24 0.26 1.11
118 INT209088 Binding of Ceacam3 and Crhr1 1 0.34 1.26 1.11
119 INT113540 Binding of OPRM1 and Tac1 1 0.04 0.1 1.1
120 INT127133 Positive_regulation of OPRM1 Positive_regulation of Protein_catabolism of SUCLG2 1 0.20 0.2 1.1
121 INT60783 Binding of Oprd1 and Cck 1 0.26 0.47 1.09
122 INT90145 Binding of OPRL1 and OPRM1 2 0.27 0.31 1.08
123 INT121089 Binding of Oprd1 and Adarb1 2 0.06 0 1.07
124 INT145407 Oprd1 Regulation of Positive_regulation of Dbi 1 0.17 0 1.07
125 INT6415 Binding of Cpe and Oprd1 1 0.00 0 1.07
126 INT87222 Nrg1 Regulation of Oprd1 1 0.00 0 1.07
127 INT94205 TACR1 Regulation of Gene_expression of SP5 1 0.04 0.72 1.06
128 INT122432 Prkci Regulation of Negative_regulation of Oprd1 1 0.01 0 1.06
129 INT18828 DNM2 Positive_regulation of Localization of LTB4R 1 0.01 0.07 1.06
130 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 0.40 0 1.05
131 INT134970 Positive_regulation of Binding of OPRK1 and SP1 1 0.00 0 1.05
132 INT97011 Binding of CALM3 and OPRM1 1 0.35 0 1.05
133 INT339333 Binding of TACR1 and TAC4 1 0.48 0.32 1.05
134 INT134969 Binding of OPRK1 and SP1 1 0.00 0 1.04
135 INT108413 Binding of OPRK1 and Oprd1 1 0.00 0.08 1.04
136 INT133075 TFAM Positive_regulation of Transcription of OPRM1 1 0.03 0 1.04
137 INT133072 GATA3 Positive_regulation of Transcription of OPRM1 1 0.35 0 1.04
138 INT318490 IRF6 Positive_regulation of LTB4R 1 0.01 4.39 1.03
139 INT51204 Positive_regulation of Binding of OPRK1 and OPRM1 1 0.38 0.3 1.03
140 INT150621 Binding of Oprm1 and Oprd1 1 0.00 0.08 1.02
141 INT182561 Ptger3 Positive_regulation of Ptger1 1 0.15 1.31 1.02
142 INT352295 Binding of P2RY2 and Agtr1a 1 0.01 0.08 1.02
143 INT182566 Ptger3 Positive_regulation of Ptgir 1 0.08 1.31 1.02
144 INT130607 Hcrt Positive_regulation of H1 1 0.59 0.39 1.02
145 INT79602 Binding of PSMA5 and Oprd1 2 0.19 1.05 1.01
146 INT6930 Binding of Oprk1 and Pomc 1 0.08 0.16 1.01
147 INT54853 Negative_regulation of Adra1a Positive_regulation of Positive_regulation of Ins1 1 0.18 0.23 1
148 INT54852 Negative_regulation of Adra1a Positive_regulation of Ins1 1 0.18 0.23 0.99
149 INT1415 Binding of OPRM1 and POMC 3 0.16 0.3 0.98
150 INT51201 Negative_regulation of Binding of OPRM1 and PENK 1 0.20 0.23 0.98
151 INT239539 Binding of CXCR2 and CALCRL 1 0.00 0.38 0.98
152 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
153 INT157522 GRM5 Regulation of Gene_expression of OPRM1 1 0.28 0 0.97
154 INT18890 Penk Regulation of Oprd1 1 0.25 0.45 0.97
155 INT40287 OPRM1 Positive_regulation of Negative_regulation of Prl 1 0.00 0.93 0.96
156 INT182203 Binding of CXCL1 and CXCR2 1 0.14 1.25 0.95
157 INT133076 STAT6 Positive_regulation of OPRM1 1 0.38 0 0.95
158 INT182207 Binding of CXCR2 and CXCL13 1 0.42 1.26 0.95
159 INT182208 Binding of CXCR2 and CXCL12 1 0.29 1.26 0.95
160 INT152388 Binding of NFKB1 and OPRM1 1 0.04 0.14 0.94
161 INT182193 Binding of CXCR2 and CXCL5 1 0.30 1.25 0.94
162 INT152390 Negative_regulation of Binding of JUN and OPRM1 1 0.13 0.14 0.94
163 INT65463 Bri3 Negative_regulation of Oprd1 1 0.10 0.39 0.94
164 INT152387 Binding of JUN and OPRM1 1 0.15 0.14 0.94
165 INT182197 Binding of CXCR2 and CCL16 1 0.00 1.24 0.94
166 INT152389 Negative_regulation of Binding of NFKB1 and OPRM1 1 0.05 0.14 0.94
167 INT81329 Binding of ARRB1 and OPRK1 1 0.05 0.1 0.93
168 INT116930 OPRK1 Positive_regulation of Binding of PTK2 1 0.28 0.35 0.93
169 INT82126 CEBPB Regulation of Gene_expression of Oprd1 1 0.00 0 0.93
170 INT82124 IK Positive_regulation of Gene_expression of Oprd1 1 0.00 0 0.92
171 INT128860 NR1H4 Negative_regulation of Gene_expression of OPRM1 1 0.15 0.31 0.92
172 INT55564 Binding of Oprk1 and Pde6b 1 0.01 0 0.92
173 INT72917 Binding of Crh and Crhr1 4 0.32 0.73 0.91
174 INT34271 Positive_regulation of WAS Positive_regulation of Oprd1 1 0.01 0 0.91
175 INT34273 WAS Regulation of Oprd1 1 0.00 0 0.91
176 INT61317 Positive_regulation of Oprd1 Positive_regulation of Gene_expression of Coq10a 1 0.01 0.39 0.91
177 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91
178 INT34272 WAS Positive_regulation of Oprd1 1 0.01 0 0.91
179 INT77330 Oprk1 Regulation of Localization of GRIN1 1 0.24 0 0.91
180 INT54196 Binding of Oprd1 and Agp2 1 0.00 0.18 0.91
181 INT89314 Binding of CRYGS and OPRM1 1 0.07 0.08 0.91
182 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
183 INT52114 Oprd1 Regulation of ADCY1 2 0.05 0.46 0.9
184 INT113946 Binding of FLNA and OPRM1 1 0.10 0.37 0.9
185 INT52759 Oprd1 Regulation of Sptan1 1 0.03 0 0.9
186 INT86589 Oprd1 Regulation of Localization of Pomc 1 0.18 0 0.9
187 INT52760 Oprd1 Regulation of Drd1a 1 0.02 0 0.9
188 INT128859 Positive_regulation of RXRA Regulation of Gene_expression of OPRM1 1 0.05 0.26 0.9
189 INT91270 Oprd1 Regulation of Gene_expression of Il6 1 0.00 0 0.89
190 INT161916 Binding of POMC and Oprd1 1 0.01 0 0.89
191 INT161917 Negative_regulation of Binding of POMC and Oprd1 1 0.01 0 0.89
192 INT59503 Binding of Oprd1 and Insrr 1 0.00 0 0.89
193 INT257304 Pde5a Positive_regulation of Oprd1 1 0.15 0.48 0.89
194 INT54194 Binding of Oprd1 and Pag1 1 0.01 0.18 0.89
195 INT82125 IK Regulation of Gene_expression of Oprd1 1 0.00 0 0.88
196 INT62956 CXCR2 Positive_regulation of IL8 1 0.30 0 0.88
197 INT207439 Binding of HCRT and ERAL1 1 0.00 3.06 0.87
198 INT337899 Positive_regulation of MC3R Positive_regulation of Gene_expression of Bdnf 1 0.31 0 0.87
199 INT80792 Prkcg Regulation of Oprd1 1 0.19 0.2 0.86
200 INT37839 Positive_regulation of Binding of Cyp27b1 and Oprd1 1 0.01 0 0.86

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger. They are ordered first by their pain relevance and then by number of times they were reported in activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5660 Binding of Oprd1 477 0.48 71.86 342.06
2 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32
3 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41
4 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
5 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9
6 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11
7 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
8 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
9 INT12569 Localization of Oprd1 94 0.81 23.81 104.56
10 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97
11 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
12 INT18032 Positive_regulation of Oprk1 108 0.70 30.78 89.7
13 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
14 INT20964 Gene_expression of OPRK1 96 0.78 23.54 58.18
15 INT37219 Gene_expression of TACR1 56 0.78 32.4 54.16
16 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54
17 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
18 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12
19 INT10304 Binding of OPRK1 89 0.48 9.28 49.42
20 INT32718 Gene_expression of OPRD1 82 0.76 9.43 48.38
21 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69
22 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
23 INT7828 Positive_regulation of Oprd1 55 0.69 14.11 42.86
24 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58
25 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
26 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29
27 INT51685 Gene_expression of LTB4R 87 0.58 68.69 31.72
28 INT12397 Gene_expression of Oprd1 53 0.78 9.1 31.31
29 INT7845 Regulation of OPRK1 44 0.62 4.54 30.49
30 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
31 INT15000 Transcription of Oprd1 32 0.72 5.7 29.22
32 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
33 INT5771 Binding of Oprd1 37 0.48 2.6 27.54
34 INT29107 Regulation of Oprk1 31 0.45 6.16 26.61
35 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48
36 INT6934 Binding of OPRD1 51 0.48 7.72 25.73
37 INT6179 Binding of Oprk1 37 0.48 9.24 24.83
38 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52
39 INT30386 Negative_regulation of OPRD1 33 0.52 4.34 23.06
40 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
41 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
42 INT31393 Positive_regulation of Localization of Oprd1 10 0.66 7.32 21.23
43 INT27529 Phosphorylation of Oprd1 23 0.47 1.16 20.18
44 INT48006 Negative_regulation of Oprk1 27 0.58 10.14 19.11
45 INT31905 Positive_regulation of Binding of Oprd1 21 0.66 3.31 18.44
46 INT28642 Gene_expression of CXCR2 60 0.78 38.69 18.11
47 INT8332 Positive_regulation of OPRD1 30 0.61 3.88 17.65
48 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
49 INT32753 Positive_regulation of Positive_regulation of OPRM1 19 0.62 3.3 16.73
50 INT6066 Negative_regulation of Positive_regulation of Oprd1 15 0.43 1.36 16.63
51 INT4769 Regulation of OPRD1 20 0.44 2.05 15.97
52 INT9751 Localization of Crhr1 26 0.78 10.47 15.69
53 INT29352 Negative_regulation of Oprd1 16 0.58 6.51 14.6
54 INT54284 Negative_regulation of Gene_expression of Oprd1 16 0.42 4.56 14.34
55 INT18658 Regulation of Adra1a 34 0.62 5.69 13.78
56 INT79703 Gene_expression of Agtr1a 46 0.76 14.18 13.77
57 INT76863 Negative_regulation of Gene_expression of OPRM1 21 0.57 6.56 13.69
58 INT80883 Positive_regulation of Phosphorylation of OPRM1 13 0.69 1.03 13.65
59 INT20881 Negative_regulation of OPRK1 20 0.43 3.73 13.37
60 INT3962 Regulation of AGT 50 0.62 20.96 13.01
61 INT44 Positive_regulation of Adra1a 30 0.68 7.09 12.73
62 INT57580 Positive_regulation of TACR1 18 0.69 9.35 12.47
63 INT99587 Positive_regulation of Gene_expression of Oprk1 15 0.57 5.26 12.39
64 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68
65 INT398 Localization of AGT 45 0.78 16.97 11.54
66 INT23122 Gene_expression of Ptger3 31 0.72 11.94 11.37
67 INT76138 Transcription of Oprk1 21 0.72 5.79 11.25
68 INT90903 Positive_regulation of Positive_regulation of Oprk1 13 0.47 3.49 11.18
69 INT104039 Positive_regulation of Crhr1 15 0.70 8.34 10.99
70 INT6870 Positive_regulation of Oprk1 14 0.70 4 10.91
71 INT8065 Binding of AGT 54 0.48 20.54 10.85
72 INT14124 Negative_regulation of Adra1a 34 0.59 7.48 10.85
73 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29
74 INT348 Regulation of Adra1a 25 0.45 3.33 10.27
75 INT18833 Positive_regulation of LTB4R 19 0.69 27.61 10.17
76 INT475 Negative_regulation of Adra1a 28 0.58 7.87 9.83
77 INT51168 Localization of TACR1 10 0.80 7.66 9.83
78 INT55014 Positive_regulation of Ednrb 31 0.70 16.61 9.68
79 INT105816 Gene_expression of P2RY2 53 0.78 16.47 9.67
80 INT2828 Positive_regulation of Ptger3 26 0.68 8.01 9.63
81 INT53547 Binding of TACR1 22 0.48 5.03 9.48
82 INT7697 Positive_regulation of Adra1a 22 0.68 2.3 9.16
83 INT51837 Negative_regulation of TACR1 17 0.43 6.5 9.12
84 INT33209 Positive_regulation of Binding of OPRM1 8 0.68 0.63 8.95
85 INT7572 Regulation of Crhr1 8 0.45 5.6 8.93
86 INT69528 Regulation of Gene_expression of Oprk1 10 0.45 4.27 8.84
87 INT21566 Regulation of Oprk1 10 0.62 3.4 8.63
88 INT123382 Gene_expression of Cxcr2 12 0.69 4.62 8.62
89 INT81610 Phosphorylation of TACR1 1 0.81 0.76 8.38
90 INT53798 Gene_expression of Oprk1 14 0.73 1.82 8.24
91 INT106056 Gene_expression of Hcrt 77 0.76 35.35 8.16
92 INT81153 Gene_expression of Hcrt 31 0.77 6.04 8.16
93 INT1448 Binding of Adra1a 23 0.48 1.41 8.01
94 INT50191 Positive_regulation of Gene_expression of OPRK1 9 0.67 3.44 7.91
95 INT31394 Negative_regulation of Localization of Oprd1 3 0.39 2.38 7.89
96 INT31060 Negative_regulation of Binding of OPRM1 12 0.37 2.65 7.75
97 INT101721 Positive_regulation of Transcription of OPRM1 8 0.48 1.22 7.74
98 INT83954 Binding of Cxcr2 21 0.37 17.27 7.65
99 INT7570 Transcription of Crhr1 7 0.66 6.6 7.6
100 INT165 Regulation of HRH1 12 0.45 1.76 7.57
101 INT105185 Negative_regulation of Gene_expression of Oprk1 9 0.42 3.53 7.53
102 INT74326 Gene_expression of Crhr1 25 0.66 9.7 7.48
103 INT49932 Gene_expression of Ptger3 33 0.71 8.77 7.39
104 INT121815 Regulation of Positive_regulation of OPRM1 7 0.62 0.75 7.36
105 INT76253 Positive_regulation of P2RY2 29 0.70 13.99 7.33
106 INT80161 Positive_regulation of Crhr1 13 0.67 9.66 7.33
107 INT20845 Positive_regulation of Negative_regulation of Oprd1 7 0.70 1.81 7.33
108 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27
109 INT6239 Regulation of Regulation of Oprd1 7 0.45 0.34 7.26
110 INT83951 Gene_expression of Cxcr2 31 0.71 19.36 7.24
111 INT5311 Regulation of Negative_regulation of Oprd1 11 0.43 0.99 7.23
112 INT12699 Transcription of OPRK1 11 0.52 0.08 6.66
113 INT54062 Transcription of Oprd1 11 0.68 1.05 6.65
114 INT9753 Positive_regulation of Localization of Crhr1 8 0.49 1.72 6.55
115 INT50130 Positive_regulation of Ptger3 13 0.67 5.23 6.47
116 INT7842 Gene_expression of Adra1a 14 0.67 1.99 6.39
117 INT78178 Gene_expression of Ednrb 21 0.75 7.1 6.37
118 INT42832 Negative_regulation of Positive_regulation of OPRM1 6 0.36 0.96 6.35
119 INT290523 Phosphorylation of Oprk1 3 0.81 3.1 6.34
120 INT85655 Gene_expression of Crhr1 17 0.68 9.34 6.31
121 INT54747 Localization of OPRD1 7 0.73 0.69 6.27
122 INT84779 Positive_regulation of Hcrt 9 0.70 1.27 6.21
123 INT97600 Regulation of Transcription of OPRM1 8 0.52 1.14 6.21
124 INT16210 Localization of LTB4R 14 0.54 6.58 6.19
125 INT233812 Gene_expression of PTH1R 32 0.77 18.15 6.15
126 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14
127 INT262 Localization of Ptger3 17 0.61 3.03 6.1
128 INT91575 Positive_regulation of Phosphorylation of Oprd1 8 0.02 0.23 6.07
129 INT335 Binding of Adra1a 16 0.36 6.16 6
130 INT27118 Regulation of Binding of OPRM1 10 0.62 1.18 5.97
131 INT76741 Localization of OPRK1 7 0.68 0.22 5.9
132 INT26555 Regulation of Positive_regulation of Oprd1 6 0.59 2.47 5.76
133 INT119523 Gene_expression of EDNRB 32 0.75 26.47 5.75
134 INT110545 Regulation of Regulation of OPRM1 7 0.42 1.68 5.67
135 INT127062 Positive_regulation of Gene_expression of LTB4R 18 0.34 15.9 5.64
136 INT16211 Negative_regulation of LTB4R 11 0.29 13 5.62
137 INT14388 Regulation of TACR1 12 0.45 3.1 5.58
138 INT32979 Positive_regulation of Localization of OPRM1 5 0.50 0 5.54
139 INT72000 Gene_expression of Gnaq 17 0.75 3.12 5.48
140 INT104226 Localization of Oprk1 12 0.75 3.22 5.41
141 INT23725 Gene_expression of CCKAR 14 0.55 0.14 5.3
142 INT102891 Positive_regulation of AGTR1 31 0.67 30.57 5.29
143 INT74182 Positive_regulation of Binding of OPRK1 8 0.49 1.39 5.25
144 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15
145 INT40638 Binding of HRH1 14 0.44 5.81 5.09
146 INT29354 Regulation of Binding of OPRK1 7 0.60 1.72 5.04
147 INT109848 Gene_expression of P2RY1 26 0.62 6.71 4.98
148 INT42833 Positive_regulation of Negative_regulation of OPRM1 6 0.48 0.12 4.95
149 INT62958 Positive_regulation of CXCR2 14 0.59 8.61 4.92
150 INT81609 Positive_regulation of Phosphorylation of TACR1 1 0.60 0.33 4.91
151 INT99785 Positive_regulation of Cxcr2 10 0.53 8.03 4.89
152 INT18245 Negative_regulation of Localization of Crhr1 4 0.17 0.28 4.81
153 INT34132 Binding of Oprk1 6 0.48 2.15 4.78
154 INT7568 Negative_regulation of Crhr1 8 0.43 4.63 4.77
155 INT51679 Negative_regulation of Gene_expression of LTB4R 12 0.29 7.21 4.74
156 INT29519 Gene_expression of Ednrb 8 0.66 1.99 4.55
157 INT92446 Positive_regulation of Gene_expression of TACR1 4 0.35 2.68 4.5
158 INT36855 Gene_expression of P2RY6 19 0.42 6.16 4.45
159 INT92133 Negative_regulation of Ednrb 8 0.42 1.7 4.44
160 INT3332 Protein_catabolism of AGT 23 0.87 3.17 4.39
161 INT23738 Regulation of Transcription of Oprd1 6 0.26 0.48 4.3
162 INT102363 Negative_regulation of Positive_regulation of OPRK1 7 0.43 0.99 4.25
163 INT4148 Gene_expression of HRH1 11 0.77 2.71 4.22
164 INT53040 Binding of Agtr1a 22 0.47 7.36 4.15
165 INT152312 Positive_regulation of Ednrb 7 0.49 1.46 4.04
166 INT29671 Regulation of Localization of Oprd1 4 0.24 1.04 3.92
167 INT29394 Gene_expression of Adra1a 9 0.77 3.62 3.91
168 INT65460 Positive_regulation of Gene_expression of Oprd1 8 0.69 1.87 3.87
169 INT71322 Positive_regulation of Binding of Oprd1 4 0.33 0.97 3.87
170 INT76707 Negative_regulation of Gene_expression of Ptger3 6 0.20 2.56 3.73
171 INT80882 Negative_regulation of Phosphorylation of OPRM1 4 0.45 0.21 3.68
172 INT23728 Negative_regulation of CCKAR 6 0.42 0.48 3.53
173 INT85537 Regulation of Crhr1 4 0.45 1.64 3.53
174 INT93463 Localization of Hcrt 13 0.78 1.58 3.51
175 INT41296 Protein_catabolism of Oprd1 8 0.85 0.79 3.48
176 INT106057 Negative_regulation of Hcrt 27 0.57 15.5 3.47
177 INT60646 Regulation of Gene_expression of Oprd1 4 0.60 1.76 3.46
178 INT118270 Regulation of P2RY2 16 0.45 7.02 3.45
179 INT52392 Positive_regulation of Gene_expression of OPRD1 6 0.64 0.23 3.43
180 INT236824 Negative_regulation of Gene_expression of PTH1R 10 0.58 9.3 3.42
181 INT66782 Negative_regulation of Gene_expression of OPRK1 4 0.28 1.42 3.41
182 INT126560 Binding of P2RY2 12 0.44 6.43 3.4
183 INT13347 Regulation of Negative_regulation of OPRM1 5 0.45 0.64 3.38
184 INT12388 Negative_regulation of Crhr1 17 0.59 9.47 3.33
185 INT16212 Negative_regulation of Localization of LTB4R 6 0.39 1.9 3.26
186 INT74962 Phosphorylation of OPRD1 5 0.82 0.18 3.26
187 INT84222 Regulation of Ednrb 4 0.45 2.24 3.25
188 INT59301 Negative_regulation of Positive_regulation of Oprk1 4 0.58 1.33 3.24
189 INT88748 Binding of Hcrt 7 0.47 0 3.22
190 INT127336 Positive_regulation of Transcription of Crhr1 3 0.48 3.37 3.19
191 INT54060 Regulation of Transcription of Oprd1 3 0.57 0.59 3.18
192 INT38030 Positive_regulation of P2RY1 15 0.67 5.54 3.17
193 INT111195 Negative_regulation of Gene_expression of Agtr1a 7 0.58 3.2 3.16
194 INT82035 Negative_regulation of Phosphorylation of Oprd1 3 0.13 0 3.16
195 INT8043 Binding of Ntsr2 3 0.31 0.11 3.12
196 INT31912 Regulation of Binding of OPRD1 3 0.25 0.93 3.11
197 INT59455 Localization of Oprd1 3 0.20 0.22 3.01
198 INT51686 Regulation of Gene_expression of LTB4R 10 0.26 5.02 2.99
199 INT57145 Transcription of OPRD1 6 0.61 0.34 2.99
200 INT69822 Binding of Ptger3 9 0.39 2.98 2.97
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