GO:0007202

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Name activation of phospholipase C activity
Categary Process
Go Slim No
Go Link GO:0007202
Unique Molecular Interactions 821
Total Molecular Interactions 1134
Total Single Events 7562
Pain Genes Associated 44

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of phospholipase C activity. They are ordered first by their pain relevance and then by number of times they were reported for activation of phospholipase C activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1
2 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
3 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81
4 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
5 INT212301 NGF Regulation of Gene_expression of TRPV1 1 0.23 2.37 2.13
6 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
7 INT271408 NGF Positive_regulation of Gene_expression of CALCA 1 0.09 4.89 1.88
8 INT185097 NGF Regulation of Gene_expression of NAV1 1 0.61 0.81 1.85
9 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
10 INT136273 NGF Regulation of Gene_expression of BDNF 2 0.41 1.14 1.78
11 INT86997 Binding of HIVEP1 and NGF 2 0.03 1.75 1.73
12 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
13 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
14 INT145098 NGF Positive_regulation of BDNF 1 0.66 1.33 1.67
15 INT108066 Binding of NTRK1 and Ngf 3 0.33 2.56 1.66
16 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
17 INT266768 NGF Positive_regulation of Localization of SFTPA1 1 0.01 1.65 1.6
18 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
19 INT166676 Binding of PRKCA and UGT1A6 1 0.30 0 1.5
20 INT159657 Binding of INSRR and NGF 3 0.00 1.65 1.48
21 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48
22 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48
23 INT266771 Binding of NGF and GOPC 1 0.05 3.23 1.43
24 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39
25 INT118980 NTRK1 Positive_regulation of NGF 1 0.56 1.45 1.39
26 INT250934 Binding of BDNF and NGF 3 0.39 0.62 1.34
27 INT181492 NGF Regulation of TRPV1 1 0.21 0.93 1.31
28 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
29 INT112961 NGF Positive_regulation of ICAM1 1 0.40 0.96 1.28
30 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
31 INT162482 Binding of Agt and Vta1 1 0.23 0 1.27
32 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
33 INT108067 Negative_regulation of Binding of NTRK1 and Ngf 1 0.06 2.38 1.2
34 INT65203 OPRL1 Negative_regulation of ADCY1 1 0.19 0 1.19
35 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
36 INT98908 Binding of NTRK1 and PKLR 1 0.41 1.95 1.18
37 INT98906 Positive_regulation of Binding of NTRK1 and PKLR 1 0.56 1.95 1.18
38 INT65204 PNOC Negative_regulation of ADCY1 1 0.07 0 1.14
39 INT160540 Binding of NGF and PSIP1 2 0.29 1.43 1.12
40 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
41 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09
42 INT181494 TRPV3 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
43 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
44 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 0.40 0 1.05
45 INT97011 Binding of CALM3 and OPRM1 1 0.35 0 1.05
46 INT54853 Negative_regulation of Adra1a Positive_regulation of Positive_regulation of Ins1 1 0.18 0.23 1
47 INT53052 ANTXRL Negative_regulation of Negative_regulation of ADCY1 1 0.01 0.66 0.99
48 INT54852 Negative_regulation of Adra1a Positive_regulation of Ins1 1 0.18 0.23 0.99
49 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98
50 INT69506 CA2 Positive_regulation of PRKCA 1 0.50 0.42 0.98
51 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
52 INT127672 Binding of NGFR and NTRK1 1 0.17 2.28 0.97
53 INT271409 NGF Positive_regulation of TRPV1 1 0.08 2.45 0.94
54 INT271410 NGF Positive_regulation of Gene_expression of TRPV1 1 0.07 2.45 0.94
55 INT72213 Positive_regulation of PRKCA Regulation of Gene_expression of METTL3 1 0.05 0.17 0.93
56 INT127673 NGF Regulation of Gene_expression of NTRK1 1 0.48 2.12 0.92
57 INT12050 Agt Positive_regulation of Localization of Oxt 1 0.29 0 0.91
58 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
59 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
60 INT52114 Oprd1 Regulation of ADCY1 2 0.05 0.46 0.9
61 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
62 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
63 INT165540 NGF Positive_regulation of GRIN1 1 0.07 0.17 0.88
64 INT52390 OPRD1 Regulation of ADCY1 1 0.09 0.13 0.86
65 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 0.02 0.05 0.85
66 INT114323 Binding of ADCY6 and RAF1 1 0.02 0.05 0.85
67 INT69424 Binding of Agt and Oprd1 1 0.14 0 0.84
68 INT128702 Ednra Regulation of EDNRA 1 0.00 0.58 0.84
69 INT80877 Negative_regulation of PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84
70 INT80878 PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84
71 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82
72 INT19299 ANG Regulation of AVP 1 0.25 0 0.82
73 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
74 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
75 INT47143 Negative_regulation of Agt Positive_regulation of Avp 1 0.22 0 0.79
76 INT220056 Binding of NTF3 and NTRK1 1 0.07 1.12 0.78
77 INT81976 Binding of GNA15 and OPRL1 1 0.02 0 0.77
78 INT124384 ADRBK1 Negative_regulation of MC1R 1 0.40 0.42 0.77
79 INT65593 CALCA Negative_regulation of Positive_regulation of ADCY1 1 0.23 0.07 0.76
80 INT166674 YY1 Regulation of Binding of PRKCA 1 0.38 0 0.75
81 INT309735 Binding of CALM3 and TRPV4 1 0.14 0 0.75
82 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
83 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71
84 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71
85 INT166673 PRKCA Negative_regulation of UGT1A6 1 0.36 0 0.69
86 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68
87 INT140235 ADRBK1 Positive_regulation of Binding of MC1R 1 0.46 0.31 0.68
88 INT141063 Agt Regulation of Agtr1a 1 0.28 1.18 0.68
89 INT140237 Gene_expression of ADRBK1 Positive_regulation of Gene_expression of MC1R 1 0.46 0.31 0.68
90 INT74599 YY1 Negative_regulation of ADCY1 2 0.36 0.31 0.67
91 INT118979 NGF Positive_regulation of Phosphorylation of NTRK1 1 0.56 0.67 0.67
92 INT134286 PLD2 Regulation of Regulation of EDNRA 1 0.10 0 0.67
93 INT299989 PRKCA Positive_regulation of Gene_expression of IL8 1 0.04 0.45 0.67
94 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
95 INT169213 Binding of EGFR and CARTPT 1 0.00 0.22 0.67
96 INT189704 PRKCA Regulation of CHKB 1 0.13 0.18 0.66
97 INT334128 Acsm3 Positive_regulation of Sele 1 0.16 1.6 0.66
98 INT47145 Penk Negative_regulation of Agt 1 0.06 0 0.66
99 INT114843 NTRK1 Regulation of Gene_expression of Lgals1 1 0.06 0.84 0.66
100 INT162878 Agt Regulation of Ang 1 0.21 1.15 0.66
101 INT176476 TNF Positive_regulation of Gene_expression of SELE 1 0.04 0.57 0.63
102 INT255994 Binding of Ang and Il1rn 1 0.09 1.21 0.63
103 INT219921 EDNRA Negative_regulation of Trpv1 1 0.13 0.36 0.63
104 INT192332 UBR7 Negative_regulation of TXK 1 0.00 1.38 0.63
105 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
106 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
107 INT57421 Oprd1 Regulation of Agt 1 0.29 0 0.62
108 INT337323 KNG1 Positive_regulation of PRKCA 1 0.15 0.17 0.62
109 INT230734 Negative_regulation of Binding of EDNRA and Pah 1 0.02 3.26 0.61
110 INT113962 OPRM1 Regulation of CREB1 1 0.39 0.31 0.6
111 INT230735 Binding of EDNRA and Pah 1 0.02 3.22 0.6
112 INT81606 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TACR1 1 0.29 0 0.6
113 INT275063 CA2 Positive_regulation of Positive_regulation of CAMK4 1 0.01 0 0.59
114 INT56116 Agt Positive_regulation of Lhb 1 0.15 0 0.58
115 INT169290 CNR1 Positive_regulation of Negative_regulation of TXK 1 0.10 0.18 0.58
116 INT164457 Ngf Positive_regulation of NTRK1 1 0.15 0.57 0.58
117 INT103165 NGF Positive_regulation of Localization of INS 1 0.05 0 0.58
118 INT164458 Negative_regulation of Ngf Positive_regulation of NTRK1 1 0.14 0.57 0.58
119 INT81605 PRKCA Positive_regulation of Phosphorylation of TACR1 1 0.43 0 0.57
120 INT169286 CNR1 Positive_regulation of Phosphorylation of EGFR 1 0.45 0.18 0.57
121 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
122 INT73368 Ang1 Negative_regulation of Fabp6 1 0.00 0.44 0.56
123 INT56117 Agt Positive_regulation of Positive_regulation of CGA 1 0.00 0 0.56
124 INT323148 PRKCA Positive_regulation of RAF1 1 0.01 0 0.55
125 INT210830 OPRM1 Negative_regulation of ADCY1 1 0.00 0.06 0.55
126 INT323150 PRKCA Positive_regulation of Phosphorylation of RAF1 1 0.01 0 0.55
127 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
128 INT64744 OR5D2P Negative_regulation of ADCY1 1 0.00 0 0.54
129 INT73367 Agt Negative_regulation of Localization of Calca 1 0.43 0.26 0.54
130 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
131 INT255999 Binding of Ang and H7 1 0.00 0.38 0.54
132 INT69343 Binding of NTRK1 and Igh-6 1 0.02 0.69 0.53
133 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53
134 INT187101 Selp Regulation of Sele 1 0.20 1.23 0.53
135 INT79809 Binding of Agtr1a and Adra1a 1 0.02 0.23 0.53
136 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
137 INT256019 Agt Negative_regulation of Lnpep 1 0.23 1.76 0.53
138 INT106392 ADRBK1 Regulation of Negative_regulation of OPRL1 1 0.27 0.06 0.52
139 INT120383 PRKCD Positive_regulation of Localization of EPHB2 1 0.29 0.42 0.52
140 INT120384 PRKCD Positive_regulation of Localization of HSPG2 1 0.29 0.42 0.51
141 INT120382 PRKCD Positive_regulation of Localization of DYT10 1 0.29 0.42 0.51
142 INT93265 Binding of ADCY1 and OPRL1 1 0.13 0.17 0.51
143 INT189688 PRKCA Regulation of Transcription of TERT 1 0.13 0.2 0.5
144 INT189696 PRKCA Negative_regulation of Negative_regulation of TEP1 1 0.02 0.15 0.5
145 INT139834 NFKB1 Regulation of Gene_expression of SELE 1 0.18 0.49 0.5
146 INT189680 PRKCA Negative_regulation of TEP1 1 0.02 0.15 0.5
147 INT139835 NFKB1 Regulation of SELE 1 0.41 0.49 0.5
148 INT189675 Negative_regulation of PRKCA Negative_regulation of TEP1 1 0.02 0.15 0.5
149 INT127677 NGF Regulation of Gene_expression of NGFR 1 0.20 1.11 0.5
150 INT220741 Binding of EGFR and SOAT1 1 0.02 0.37 0.49
151 INT81331 ADRBK1 Regulation of OPRK1 1 0.03 0.09 0.48
152 INT39078 Binding of Agt and Penk 1 0.24 0.42 0.48
153 INT341428 EPO Positive_regulation of NGF 1 0.52 0.37 0.48
154 INT47144 Negative_regulation of Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
155 INT34006 Binding of ITPR3 and YY1 1 0.22 0.33 0.48
156 INT47146 Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
157 INT261648 BDKRB1 Regulation of PRKCA 1 0.03 1.9 0.47
158 INT341426 EPO Regulation of NGF 1 0.51 0.5 0.47
159 INT89647 OPRM1 Regulation of ADCY1 1 0.09 0.09 0.47
160 INT142826 UPF1 Positive_regulation of CREB1 1 0.11 0 0.46
161 INT153658 PRKCA Negative_regulation of GEM 1 0.01 0.22 0.46
162 INT153657 PRKCA Negative_regulation of MED23 1 0.01 0.22 0.46
163 INT39077 Agt Negative_regulation of Prss12 1 0.05 0.44 0.46
164 INT19297 ANG Positive_regulation of AVP 1 0.28 0 0.46
165 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
166 INT349686 Nmu Positive_regulation of Nmur1 1 0.36 0.2 0.45
167 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
168 INT151958 Negative_regulation of Agt Positive_regulation of Agtrap 1 0.39 0 0.44
169 INT94093 Pnoc Positive_regulation of EDNRA 1 0.03 0.1 0.44
170 INT258584 ADORA3 Negative_regulation of ADCY1 1 0.02 0 0.44
171 INT111275 BRI3P1 Positive_regulation of Negative_regulation of ADCY1 1 0.06 0 0.44
172 INT89649 INSRR Regulation of ADCY1 1 0.00 0.07 0.44
173 INT111274 C2 Positive_regulation of Negative_regulation of ADCY1 1 0.14 0 0.44
174 INT151959 Agt Positive_regulation of Agtrap 1 0.63 0 0.44
175 INT47101 Adra1a Regulation of Localization of Gnrhr 1 0.02 0.24 0.44
176 INT73832 Pld1 Positive_regulation of ADCY1 1 0.00 0.16 0.44
177 INT114341 Agt Positive_regulation of AGT 3 0.01 1.15 0.43
178 INT337326 PIK3CD Positive_regulation of Localization of ITPR3 1 0.02 0 0.43
179 INT184543 Agt Positive_regulation of Ccl2 1 0.16 3.18 0.43
180 INT337324 PIK3CD Positive_regulation of Gene_expression of ITPR3 1 0.02 0 0.43
181 INT36459 Binding of Agt and Positive_regulation of Localization of Avp 1 0.38 0.19 0.43
182 INT201092 Binding of KNG1 and NGF 1 0.00 0.31 0.43
183 INT86972 PDE1B Positive_regulation of Localization of Gh 1 0.00 0 0.42
184 INT127676 NGF Regulation of TNFRSF1B 1 0.21 1.02 0.42
185 INT80824 NGF Positive_regulation of NTF3 1 0.47 0.26 0.42
186 INT127675 NGF Regulation of NTRK1 1 0.48 1.01 0.42
187 INT127674 NGF Regulation of Gene_expression of TNFRSF1B 1 0.48 1.02 0.42
188 INT242992 Binding of Agt and Ppara 1 0.20 1.44 0.42
189 INT68526 Binding of ADCY1 and DIO2 1 0.01 0.07 0.41
190 INT68527 Binding of ADCY1 and OPRD1 1 0.06 0.07 0.41
191 INT105170 OPRD1 Positive_regulation of Phosphorylation of ADCY1 1 0.08 0 0.41
192 INT19298 ANG Regulation of OXT 1 0.07 0 0.41
193 INT189681 Negative_regulation of PRKCA Negative_regulation of Gene_expression of METTL3 1 0.00 0.16 0.41
194 INT11425 OR2A12 Positive_regulation of Negative_regulation of ADCY1 1 0.01 0 0.4
195 INT36460 Binding of Agt and Avp 1 0.28 0.16 0.4
196 INT105169 RAF1 Regulation of Positive_regulation of ADCY1 1 0.12 0 0.4
197 INT189689 CHKB Negative_regulation of Positive_regulation of PRKCA 1 0.11 0 0.4
198 INT124799 PRKCA Positive_regulation of Localization of ADCY6 1 0.19 0 0.4
199 INT275156 Agt Positive_regulation of Rac1 1 0.03 2.89 0.4
200 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of phospholipase C activity. They are ordered first by their pain relevance and then by number of times they were reported in activation of phospholipase C activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45
2 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
3 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9
4 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
5 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
6 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
7 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
8 INT1158 Regulation of Agt 106 0.61 29.4 30.29
9 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11
10 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
11 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
12 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64
13 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
14 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92
15 INT62373 Negative_regulation of NGF 34 0.59 25.87 22.38
16 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24
17 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41
18 INT49487 Gene_expression of Sele 65 0.76 68.11 19.41
19 INT61257 Gene_expression of Sele 79 0.77 70.97 17.78
20 INT20216 Localization of NGF 40 0.80 18.16 16.61
21 INT84924 Positive_regulation of Gene_expression of NGF 29 0.68 17.91 16.46
22 INT2066 Localization of Agt 56 0.80 9.95 16.25
23 INT12617 Regulation of ADCY1 41 0.61 7.38 15.94
24 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47
25 INT71150 Binding of NGF 22 0.46 13.67 14.81
26 INT18658 Regulation of Adra1a 34 0.62 5.69 13.78
27 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66
28 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
29 INT44 Positive_regulation of Adra1a 30 0.68 7.09 12.73
30 INT4199 Binding of Agt 76 0.48 21.06 12.66
31 INT11429 Gene_expression of ADCY1 26 0.74 5.89 11.93
32 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79
33 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
34 INT72221 Localization of PRKCA 17 0.81 1.23 11.47
35 INT40486 Positive_regulation of Positive_regulation of ADCY1 20 0.48 4.29 11.33
36 INT14124 Negative_regulation of Adra1a 34 0.59 7.48 10.85
37 INT85048 Regulation of NGF 19 0.62 11.61 10.5
38 INT348 Regulation of Adra1a 25 0.45 3.33 10.27
39 INT12620 Negative_regulation of Negative_regulation of ADCY1 16 0.44 2.98 10.1
40 INT29740 Gene_expression of ANG 55 0.78 24.53 9.86
41 INT475 Negative_regulation of Adra1a 28 0.58 7.87 9.83
42 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59
43 INT54588 Positive_regulation of CREB1 38 0.67 12.01 9.18
44 INT7697 Positive_regulation of Adra1a 22 0.68 2.3 9.16
45 INT38173 Gene_expression of Ang 40 0.75 32.63 8.86
46 INT386 Positive_regulation of Gene_expression of Agt 37 0.70 15.92 8.73
47 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42
48 INT54681 Negative_regulation of Positive_regulation of ADCY1 16 0.38 2.7 8.14
49 INT1448 Binding of Adra1a 23 0.48 1.41 8.01
50 INT87271 Positive_regulation of Phosphorylation of CREB1 27 0.66 12.87 7.91
51 INT81345 Gene_expression of ADRBK1 21 0.70 2.89 7.9
52 INT54978 Binding of EDNRA 36 0.41 14.97 7.86
53 INT75526 Positive_regulation of Positive_regulation of PRKCA 16 0.50 4.34 7.46
54 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
55 INT86867 Regulation of CREB1 15 0.46 4.95 7.28
56 INT63373 Negative_regulation of Gene_expression of NGF 14 0.57 8.9 7.1
57 INT81880 Positive_regulation of Gene_expression of Sele 30 0.48 27.54 7.05
58 INT72222 Positive_regulation of Localization of PRKCA 8 0.70 0.55 6.56
59 INT63374 Regulation of Gene_expression of NGF 12 0.45 5.6 6.4
60 INT7842 Gene_expression of Adra1a 14 0.67 1.99 6.39
61 INT11154 Binding of EGFR 149 0.48 96.23 6.29
62 INT71151 Regulation of NTRK1 10 0.62 6.65 6.21
63 INT48313 Binding of NTRK1 19 0.47 14.44 6.12
64 INT335 Binding of Adra1a 16 0.36 6.16 6
65 INT6667 Gene_expression of CREB1 27 0.77 6.29 5.84
66 INT74109 Positive_regulation of Sele 26 0.48 22.32 5.84
67 INT5762 Negative_regulation of Gene_expression of Agt 18 0.57 6.09 5.84
68 INT97018 Binding of CALM3 7 0.43 0.13 5.82
69 INT26919 Gene_expression of ITPR3 47 0.42 5.86 5.79
70 INT71152 Negative_regulation of NTRK1 15 0.59 10.28 5.5
71 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49
72 INT72000 Gene_expression of Gnaq 17 0.75 3.12 5.48
73 INT81326 Positive_regulation of Gene_expression of Ang 17 0.67 18.5 5.46
74 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36
75 INT80881 Phosphorylation of ADCY1 7 0.69 1.22 5.29
76 INT62525 Positive_regulation of SELE 38 0.70 46 5.25
77 INT70800 Negative_regulation of Positive_regulation of PRKCA 9 0.34 2.18 5.17
78 INT62832 Negative_regulation of Gene_expression of SELE 16 0.49 10.6 5.12
79 INT120073 Positive_regulation of Itk 34 0.44 23.45 5.09
80 INT26334 Localization of ITPR3 39 0.49 2.53 5.07
81 INT152742 Positive_regulation of Localization of NGF 7 0.50 4.44 5.02
82 INT62822 Positive_regulation of Gene_expression of SELE 22 0.66 28.04 4.97
83 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93
84 INT166678 Negative_regulation of Phosphorylation of PRKCA 12 0.38 5.77 4.59
85 INT63651 Gene_expression of Adcyap1r1 17 0.77 2.57 4.58
86 INT14574 Positive_regulation of Negative_regulation of ADCY1 9 0.66 2.45 4.39
87 INT62526 Negative_regulation of SELE 17 0.51 15.24 4.19
88 INT63977 Positive_regulation of Sele 28 0.68 18.49 4.17
89 INT25503 Gene_expression of C5AR1 22 0.75 21.88 4.16
90 INT100741 Positive_regulation of ADRBK1 10 0.64 1.01 3.95
91 INT29394 Gene_expression of Adra1a 9 0.77 3.62 3.91
92 INT26191 Positive_regulation of ITPR3 24 0.44 1.9 3.74
93 INT63979 Regulation of Sele 13 0.54 10.64 3.7
94 INT87408 Negative_regulation of ADCY2 3 0.01 0.1 3.68
95 INT84925 Transcription of NGF 11 0.65 4.13 3.65
96 INT61253 Negative_regulation of Sele 13 0.57 11.68 3.56
97 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45
98 INT87281 Localization of ADCY1 7 0.64 1.84 3.42
99 INT72216 Regulation of Positive_regulation of PRKCA 9 0.37 1.36 3.26
100 INT53495 Negative_regulation of Negative_regulation of PRKCA 4 0.42 2.37 3.18
101 INT11015 Regulation of Phosphorylation of CREB1 4 0.46 1.45 3.17
102 INT117348 Regulation of EGFR 75 0.61 47.73 3.09
103 INT13179 Regulation of Positive_regulation of ADCY1 5 0.34 0.89 3.08
104 INT93109 Phosphorylation of NTRK1 5 0.80 3.22 2.99
105 INT59309 Negative_regulation of Gene_expression of ADCY1 3 0.42 1.04 2.98
106 INT51460 Negative_regulation of Gene_expression of Sele 8 0.52 10.18 2.89
107 INT37734 Positive_regulation of Ang 18 0.46 9.17 2.87
108 INT102969 Positive_regulation of Gene_expression of ADRBK1 7 0.46 1.21 2.87
109 INT69641 Positive_regulation of ADCY2 5 0.32 0.18 2.87
110 INT19235 Negative_regulation of PDE1B 11 0.14 2.38 2.81
111 INT30815 Binding of ADCY1 7 0.36 0.21 2.79
112 INT33219 Positive_regulation of C5AR1 14 0.67 7.75 2.74
113 INT171682 Positive_regulation of Phosphorylation of PRKCA 3 0.43 1.04 2.72
114 INT81411 Negative_regulation of Sele 8 0.38 7 2.7
115 INT45109 Binding of C5AR1 10 0.37 5.77 2.69
116 INT110503 Negative_regulation of ADRBK1 4 0.53 0.71 2.69
117 INT119518 Positive_regulation of Gene_expression of NTRK1 5 0.67 3.47 2.66
118 INT80884 Positive_regulation of Phosphorylation of ADCY1 4 0.43 0.24 2.64
119 INT98919 Negative_regulation of Phosphorylation of CREB1 8 0.58 2.4 2.63
120 INT11426 Positive_regulation of Gene_expression of ADCY1 5 0.29 0.68 2.63
121 INT148071 Gene_expression of Agt 42 0.74 44.9 2.43
122 INT4270 Negative_regulation of Negative_regulation of Agt 10 0.43 1.08 2.43
123 INT26918 Positive_regulation of Gene_expression of ITPR3 14 0.27 2.31 2.41
124 INT73671 Regulation of Gene_expression of Sele 8 0.45 7.01 2.39
125 INT143247 Positive_regulation of CAMK4 9 0.67 5.25 2.28
126 INT26335 Binding of ITPR3 22 0.18 3.3 2.27
127 INT10201 Positive_regulation of Localization of Agt 8 0.50 0.97 2.21
128 INT103298 Binding of CALCR 5 0.47 6.03 2.15
129 INT37733 Negative_regulation of Ang 11 0.41 3.23 2.09
130 INT15211 Localization of Adra1a 3 0.16 0 2.08
131 INT63375 Positive_regulation of Positive_regulation of NGF 2 0.48 1.17 2.08
132 INT12005 Negative_regulation of Localization of Agt 6 0.57 1.49 2.06
133 INT45 Negative_regulation of Positive_regulation of Adra1a 4 0.43 0.84 1.97
134 INT79915 Positive_regulation of Agt 27 0.56 12.97 1.96
135 INT66941 Localization of NTRK1 8 0.78 5.89 1.96
136 INT12801 Negative_regulation of Regulation of Agt 4 0.43 1.2 1.96
137 INT112880 Positive_regulation of Gnaq 17 0.49 1.97 1.95
138 INT118291 Binding of TXK 19 0.10 11.77 1.94
139 INT106636 Binding of PRKCA 7 0.28 3.06 1.93
140 INT43944 Negative_regulation of Positive_regulation of Agt 4 0.42 1.44 1.93
141 INT99970 Regulation of Binding of NGF 2 0.27 2.35 1.93
142 INT65545 Localization of EGFR 35 0.79 20.8 1.88
143 INT102970 Localization of ADRBK1 4 0.66 0.45 1.85
144 INT79569 Protein_catabolism of PRKCA 3 1.00 0.44 1.78
145 INT15980 Positive_regulation of Positive_regulation of Agt 6 0.50 2.99 1.76
146 INT29739 Positive_regulation of ANG 11 0.69 4.37 1.75
147 INT102893 Positive_regulation of Gene_expression of ANG 10 0.69 5.62 1.71
148 INT97571 Positive_regulation of Gene_expression of PRKCA 13 0.43 1.61 1.7
149 INT3152 Transcription of Agt 7 0.72 5.09 1.68
150 INT120505 Negative_regulation of ITPR3 6 0.27 1.46 1.68
151 INT87289 Positive_regulation of Localization of ADCY1 3 0.43 0.36 1.65
152 INT110189 Regulation of Gnaq 3 0.02 0.26 1.63
153 INT61256 Negative_regulation of Transcription of Sele 2 0.43 1.24 1.6
154 INT69917 Negative_regulation of CREB1 8 0.58 2.28 1.59
155 INT61261 Transcription of Sele 2 0.53 1.24 1.58
156 INT29395 Positive_regulation of Gene_expression of Adra1a 2 0.50 1.64 1.57
157 INT80890 Negative_regulation of Phosphorylation of ADCY1 2 0.36 0.24 1.57
158 INT71999 Negative_regulation of Gene_expression of Gnaq 3 0.41 0.08 1.56
159 INT72310 Regulation of Regulation of ADCY1 6 0.24 1.24 1.55
160 INT7333 Localization of CALM3 4 0.72 0.4 1.55
161 INT118292 Negative_regulation of Phosphorylation of EGFR 27 0.59 13.62 1.54
162 INT85046 Positive_regulation of Positive_regulation of NTRK1 2 0.50 0.63 1.51
163 INT23938 Positive_regulation of Gene_expression of EDNRA 8 0.45 9.82 1.47
164 INT119520 Gene_expression of TXK 19 0.19 17.54 1.45
165 INT129488 Regulation of Gene_expression of EDNRA 5 0.51 3.39 1.44
166 INT52713 Regulation of Negative_regulation of PRKCA 5 0.36 1.23 1.41
167 INT159303 Regulation of Negative_regulation of NGF 1 0.44 0.96 1.39
168 INT220073 Negative_regulation of Binding of NGF 1 0.23 1.1 1.39
169 INT251834 Negative_regulation of Gene_expression of ANG 5 0.59 3.95 1.38
170 INT96993 Positive_regulation of Phosphorylation of EGFR 15 0.59 5.44 1.37
171 INT14803 Positive_regulation of Positive_regulation of Adra1a 4 0.35 0.49 1.36
172 INT239215 Binding of Agt 9 0.38 6.75 1.35
173 INT11306 Regulation of Gene_expression of Agt 7 0.45 3.29 1.31
174 INT61263 Negative_regulation of Gene_expression of Sele 6 0.43 5.65 1.31
175 INT108601 Negative_regulation of Gene_expression of NTRK1 2 0.41 0.28 1.31
176 INT127725 Negative_regulation of Positive_regulation of EGFR 6 0.57 2.69 1.3
177 INT85047 Positive_regulation of Negative_regulation of NTRK1 3 0.47 2.13 1.3
178 INT120075 Gene_expression of Itk 11 0.43 6.39 1.27
179 INT80887 Negative_regulation of Regulation of ADCY1 3 0.35 0.1 1.26
180 INT23589 Positive_regulation of CALCR 9 0.67 6.73 1.25
181 INT19319 Negative_regulation of Binding of Agt 9 0.42 3.42 1.24
182 INT63978 Regulation of Gene_expression of Sele 5 0.18 4.59 1.24
183 INT235401 Negative_regulation of Gene_expression of ITPR3 4 0.20 1.69 1.24
184 INT79916 Negative_regulation of Agt 14 0.47 6 1.22
185 INT220763 Regulation of Phosphorylation of PRKCA 3 0.29 0.84 1.22
186 INT110188 Regulation of Gene_expression of Gnaq 2 0.25 0.85 1.22
187 INT75891 Regulation of ADCY2 3 0.06 0.06 1.17
188 INT28594 Positive_regulation of Transcription of Agt 2 0.47 1.3 1.15
189 INT73364 Negative_regulation of Ang1 1 0.05 0.8 1.15
190 INT72864 Positive_regulation of Gene_expression of Sele 9 0.68 7.46 1.14
191 INT114326 Phosphorylation of ADCY6 2 0.70 0.05 1.11
192 INT51264 Positive_regulation of TXK 21 0.54 10.69 1.1
193 INT96861 Binding of Ang 11 0.32 4.46 1.1
194 INT142831 Positive_regulation of Gene_expression of CREB1 3 0.69 0.08 1.1
195 INT118293 Regulation of Phosphorylation of EGFR 2 0.61 1.01 1.1
196 INT19303 Regulation of ANG 3 0.62 1.08 1.09
197 INT106404 Positive_regulation of Positive_regulation of ADRBK1 2 0.41 0.31 1.08
198 INT83465 Positive_regulation of Localization of Sele 1 0.09 2.81 1.08
199 INT83463 Localization of Sele 1 0.14 2.81 1.08
200 INT124810 Gene_expression of ADCY6 6 0.65 0 1.06
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