GO:0007204

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Name elevation of cytosolic calcium ion concentration
Categary Process
Go Slim No
Go Link GO:0007204
Unique Molecular Interactions 4813
Total Molecular Interactions 7350
Total Single Events 66594
Pain Genes Associated 206

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for elevation of cytosolic calcium ion concentration. They are ordered first by their pain relevance and then by number of times they were reported for elevation of cytosolic calcium ion concentration. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4
2 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
3 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 0.64 2.12 14.2
4 INT69886 Ngf Positive_regulation of Calca 8 0.76 2.98 12.77
5 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
6 INT106676 Binding of Trpv1 and Phax 18 0.34 4.19 12.36
7 INT166591 Binding of CALCA and DCLK3 4 0.30 0.69 12.18
8 INT145775 Ngf Positive_regulation of Trpv1 11 0.72 7.71 11.25
9 INT68514 Pnoc Positive_regulation of Oprl1 10 0.59 3.56 9.57
10 INT26468 Ghrh Positive_regulation of Localization of Gh 21 0.37 3.26 9.21
11 INT65724 Binding of Pnoc and Oprl1 8 0.33 2.94 8.82
12 INT180785 Gdnf Positive_regulation of Calca 1 0.23 1.96 8.04
13 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
14 INT140015 Avp Positive_regulation of Localization of Penk 3 0.63 3.48 6.63
15 INT251170 Clu Positive_regulation of Trpv1 1 0.28 2.61 6.49
16 INT122779 Ngf Positive_regulation of Gene_expression of Trpv1 8 0.74 4.31 6.1
17 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87
18 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
19 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
20 INT126335 Binding of Pax3 and Tac1 6 0.07 6.22 5.27
21 INT69888 Ngf Positive_regulation of Localization of Calca 4 0.52 0.51 4.95
22 INT102122 Binding of Calca and RT1-M4 7 0.29 5.83 4.94
23 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
24 INT10844 Ghrh Regulation of Gh 13 0.13 4.77 4.71
25 INT24742 Binding of Calca and Vip 1 0.37 0.18 4.68
26 INT125407 Binding of OPRL1 and PTPRM 1 0.03 0.72 4.67
27 INT351352 Binding of Trpv1 and Lpar1 1 0.21 5.86 4.62
28 INT34444 Binding of Oprl1 and Ptprg 4 0.03 0.18 4.58
29 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
30 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
31 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
32 INT38217 Penk Regulation of Localization of Avp 2 0.38 0.56 4.45
33 INT64480 Binding of OPRL1 and PNOC 2 0.33 0.23 4.38
34 INT180774 Gdnf Positive_regulation of Trpv1 1 0.33 2.43 4.37
35 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
36 INT161109 Avp Positive_regulation of Chkb 1 0.12 0.18 4.19
37 INT11613 Cck Positive_regulation of Localization of Oxt 3 0.53 0 4.17
38 INT128998 Cxcl1 Positive_regulation of Localization of Calca 1 0.66 2.96 4.15
39 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
40 INT16221 Ghrh Positive_regulation of Gh 8 0.21 1.89 4.08
41 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
42 INT11248 Gh Positive_regulation of Ghrh 2 0.26 0.09 4.04
43 INT13969 Binding of Calca and Sst 3 0.32 0.6 4.02
44 INT13966 Calca Positive_regulation of Localization of Sst 5 0.49 0.75 3.91
45 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
46 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
47 INT122349 Ngf Regulation of Trpv1 3 0.64 1.55 3.79
48 INT136525 Binding of Prokr1 and Trpv1 1 0.39 2.9 3.76
49 INT141254 Ngf Regulation of Transcription of Trpv1 1 0.53 1.37 3.74
50 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
51 INT85541 Ngf Positive_regulation of Gene_expression of Calca 2 0.55 1.84 3.71
52 INT15984 Binding of Avp and Oxt 11 0.32 1.33 3.64
53 INT34534 Binding of Penk and Oprl1 4 0.37 0 3.64
54 INT71069 Oprl1 Regulation of Gene_expression of Tac4 1 0.03 0.13 3.64
55 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
56 INT140011 Avp Positive_regulation of Dbi 2 0.07 0.93 3.61
57 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
58 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
59 INT121651 Binding of CXCL12 and CXCR4 13 0.48 17.61 3.52
60 INT87491 CALCA Positive_regulation of Gene_expression of IL8 1 0.72 0.92 3.52
61 INT158770 Binding of Trpv1 and Trpa1 5 0.34 2.07 3.5
62 INT24710 Binding of Calca and SUB1P1 1 0.01 2.09 3.48
63 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
64 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
65 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
66 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
67 INT108471 Binding of CALCA and PNOC 1 0.29 0.64 3.25
68 INT74159 Ngf Regulation of Gene_expression of Calca 2 0.60 1.66 3.22
69 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
70 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
71 INT13729 GHRH Positive_regulation of Localization of GH1 13 0.62 0.59 3.2
72 INT29657 Binding of Calca and Calcb 1 0.26 0 3.16
73 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
74 INT122780 Ngf Regulation of Gene_expression of Trpv1 4 0.65 3.74 3.11
75 INT158752 Binding of TRPV1 and Rvm 1 0.05 1.6 3.1
76 INT158751 Binding of TRPV1 and Pag1 1 0.03 1.59 3.08
77 INT122776 Gdnf Positive_regulation of Gene_expression of Trpv1 2 0.67 2.13 3.06
78 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
79 INT106338 Positive_regulation of Tacr1 Positive_regulation of Localization of Abat 5 0.34 0 3.01
80 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
81 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01
82 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
83 INT113234 Binding of Pax3 and Tacr1 3 0.12 1.54 2.93
84 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
85 INT100835 Binding of Calca and Akap12 1 0.07 0.41 2.92
86 INT166592 Binding of CALCA and RAMP1 2 0.35 0.33 2.91
87 INT73821 CALCA Positive_regulation of Localization of IL8 1 0.25 2.37 2.91
88 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
89 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
90 INT140014 Avp Negative_regulation of Chkb 1 0.04 1.58 2.86
91 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
92 INT114126 Binding of APLNR and OPRL1 1 0.01 0.47 2.85
93 INT194409 Binding of CALCA and IGKV1D-8 1 0.15 0 2.84
94 INT169134 Binding of Calca and Trpa1 1 0.37 3.37 2.79
95 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
96 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
97 INT226118 Ghrl Regulation of Prkag1 1 0.08 0.72 2.72
98 INT180779 Bdnf Regulation of Calca 1 0.09 0.23 2.71
99 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
100 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69
101 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
102 INT182564 Binding of Ptger2 and Trpv1 1 0.18 1.77 2.67
103 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
104 INT62450 Il2 Positive_regulation of Localization of Crh 1 0.43 0.59 2.64
105 INT7888 Oprl1 Regulation of Localization of Avp 4 0.49 0.25 2.63
106 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
107 INT53648 Acot1 Positive_regulation of Localization of Calca 2 0.23 0 2.61
108 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
109 INT210696 Trpv1 Regulation of Slc12a2 1 0.25 1.97 2.58
110 INT70757 Binding of Oprl1 and Pnoc 5 0.03 0.23 2.55
111 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
112 INT57624 Calca Regulation of Positive_regulation of Trh 1 0.50 0 2.53
113 INT48526 Binding of Calca and Penk 1 0.24 1.03 2.51
114 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 0.13 1.64 2.5
115 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
116 INT20411 Ghrh Positive_regulation of Gh1 6 0.56 0.62 2.47
117 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
118 INT122775 Gdnf Regulation of Gene_expression of Trpv1 4 0.59 2.72 2.42
119 INT103332 Ngf Regulation of Gene_expression of TRPV1 3 0.09 2.6 2.4
120 INT136129 Calca Positive_regulation of ATP8A2 1 0.38 0.89 2.4
121 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
122 INT107165 Binding of Gabrg1 and Trpv1 2 0.01 0.16 2.34
123 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
124 INT88730 Binding of OPRM1 and Mop3 1 0.00 0 2.34
125 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
126 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
127 INT13967 Calca Positive_regulation of Sst 1 0.45 0 2.3
128 INT152900 TRPV1 Regulation of Gene_expression of CALCA 1 0.69 0.73 2.29
129 INT152901 TRPV1 Regulation of Localization of CALCA 1 0.44 0.73 2.29
130 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28
131 INT228454 Ngf Positive_regulation of Phosphorylation of Trpv1 1 0.39 2.97 2.26
132 INT7367 Ghrh Regulation of Localization of Gh1 5 0.49 1.55 2.25
133 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
134 INT18197 Ghrh Positive_regulation of Localization of Ggh 4 0.46 0 2.23
135 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23
136 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
137 INT69887 Ngf Regulation of Calca 2 0.49 0.1 2.19
138 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
139 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
140 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
141 INT9180 Ghrh Regulation of Localization of Gh 3 0.24 0.25 2.18
142 INT140659 Phax Positive_regulation of Trpv1 3 0.49 0.68 2.18
143 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
144 INT128997 Cxcl1 Positive_regulation of Localization of Ccl2 1 0.72 1.54 2.16
145 INT66803 Oxt Regulation of Avp 7 0.16 0.19 2.15
146 INT134583 Arrb2 Regulation of Oprm1 1 0.41 1.23 2.15
147 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
148 INT135035 Binding of Hk1 and Tac1 1 0.35 0.18 2.14
149 INT212301 NGF Regulation of Gene_expression of TRPV1 1 0.23 2.37 2.13
150 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
151 INT140019 Avp Positive_regulation of Localization of Kitl 1 0.00 1 2.13
152 INT120319 Ghrh Regulation of Ngf 1 0.25 1.89 2.11
153 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
154 INT79470 Mgat4a Regulation of Localization of Calca 1 0.08 1.72 2.1
155 INT89733 Binding of Calca and Nrm 1 0.31 0.71 2.09
156 INT122660 Binding of CACNA1A and DNAH8 2 0.28 2.68 2.08
157 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
158 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
159 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07
160 INT182200 Binding of CXCR5 and CXCL13 1 0.37 2.89 2.07
161 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
162 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
163 INT167530 Phax Regulation of Gene_expression of Trpv1 1 0.16 0.86 2.05
164 INT63873 SRPX Positive_regulation of Localization of Calca 1 0.02 0.49 2.04
165 INT115042 Gdnf Regulation of Calca 1 0.53 0.25 2.03
166 INT26221 Calca Regulation of Gt(pU21)50Imeg 1 0.01 0 2.02
167 INT117821 Binding of Tacr1 and Cd4 1 0.34 0.86 2.02
168 INT35502 Ghrh Positive_regulation of Localization of Gnrhr 7 0.57 0.18 2
169 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
170 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
171 INT138960 Dbi Positive_regulation of Avp 1 0.02 1.53 2
172 INT138958 Dbi Positive_regulation of Positive_regulation of Avp 1 0.02 1.53 2
173 INT128996 Ccl2 Positive_regulation of Localization of Calca 1 0.68 1.43 2
174 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99
175 INT45423 Avp Positive_regulation of Localization of Prl 4 0.67 1.37 1.98
176 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
177 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
178 INT122381 Positive_regulation of Pnoc Positive_regulation of Oprl1 1 0.36 1.11 1.96
179 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
180 INT107738 Binding of Pld2 and Oprm1 1 0.23 0 1.93
181 INT65025 Binding of Oprm1 and Hps4 1 0.01 0 1.93
182 INT104855 Prkaca Regulation of TRPV1 3 0.06 1.52 1.92
183 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92
184 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
185 INT262558 Phax Positive_regulation of Trpv1 1 0.01 1.26 1.92
186 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
187 INT149470 Oxt Regulation of Gene_expression of Avp 1 0.46 1.2 1.92
188 INT83418 Binding of OPRL1 and Ntrk1 1 0.02 0 1.91
189 INT149469 Oxt Regulation of Gene_expression of Crh 1 0.45 1.2 1.91
190 INT93293 Ngf Regulation of Trpv1 2 0.28 0.71 1.9
191 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
192 INT169498 Binding of Oprm1 and Mirlet7a-1 1 0.32 0 1.9
193 INT161079 Mcs18 Negative_regulation of Trpv1 1 0.40 0.82 1.9
194 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
195 INT169570 Binding of ROS1 and TRPV1 3 0.33 3.07 1.89
196 INT24942 Calca Regulation of TAC1 1 0.13 0.7 1.89
197 INT151965 SORBS1 Positive_regulation of TRPV1 1 0.18 0 1.89
198 INT166945 Ngf Positive_regulation of Trpv1 1 0.01 0.47 1.88
199 INT338691 Binding of Trpv1 and Aff3 1 0.24 1.21 1.88
200 INT271408 NGF Positive_regulation of Gene_expression of CALCA 1 0.09 4.89 1.88

Single Events

The table below shows the top 100 pain related interactions that have been reported for elevation of cytosolic calcium ion concentration. They are ordered first by their pain relevance and then by number of times they were reported in elevation of cytosolic calcium ion concentration. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 2008 0.81 518.3 1408.65
2 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84
3 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59
4 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08
5 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04
6 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
7 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42
8 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42
9 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38
10 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81
11 INT2649 Regulation of Calca 433 0.62 146.05 330.95
12 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
13 INT477 Localization of Avp 813 0.81 131.58 300.4
14 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36
15 INT3579 Localization of Oxt 555 0.81 43.35 292.44
16 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05
17 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
18 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59
19 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45
20 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
21 INT1212 Binding of Oprl1 312 0.48 28.6 225.15
22 INT626 Localization of CALCA 289 0.81 125.39 221.15
23 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61
24 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92
25 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
26 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
27 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93
28 INT4768 Positive_regulation of OPRM1 212 0.70 31.09 164.28
29 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93
30 INT6042 Binding of Oprm1 248 0.48 31.77 154.34
31 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57
32 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69
33 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69
34 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2
35 INT1414 Regulation of Oprl1 169 0.62 32.05 139.99
36 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7
37 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47
38 INT4658 Binding of OPRM1 188 0.48 25.96 136.24
39 INT2541 Binding of Calca 200 0.48 67.14 134.62
40 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4
41 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74
42 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93
43 INT5008 Localization of Calca 204 0.81 80.35 125.16
44 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46
45 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75
46 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75
47 INT4207 Regulation of Avp 267 0.62 63.72 115.33
48 INT4936 Localization of Tacr1 125 0.80 35.7 107.7
49 INT114 Binding of Oprl1 139 0.48 23 103.35
50 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
51 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66
52 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03
53 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57
54 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2
55 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
56 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61
57 INT214 Localization of AVP 370 0.81 208.51 91.09
58 INT38731 Localization of Trpv1 138 0.81 52.73 90.49
59 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37
60 INT7885 Positive_regulation of Localization of Oxt 160 0.70 14.36 87.7
61 INT2149 Positive_regulation of Oxt 181 0.70 24.8 85.43
62 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03
63 INT4857 Regulation of Tacr1 115 0.62 39.01 84.52
64 INT4830 Binding of Trpv1 158 0.48 45.11 84.2
65 INT7528 Regulation of OPRM1 100 0.62 20.63 80.57
66 INT2893 Localization of Oxt 219 0.80 28.96 79.43
67 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98
68 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58
69 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46
70 INT1335 Negative_regulation of Oprl1 123 0.59 18.02 77.13
71 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7
72 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
73 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23
74 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
75 INT7886 Regulation of Localization of Avp 146 0.62 14.53 72.99
76 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
77 INT6849 Localization of IL1B 229 0.81 112.56 69.63
78 INT451 Regulation of Oxt 142 0.62 22.07 69.42
79 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15
80 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66
81 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26
82 INT7134 Localization of KNG1 127 0.79 65.73 67.97
83 INT7468 Negative_regulation of Localization of Oxt 109 0.59 9.46 66.79
84 INT5941 Gene_expression of Oxt 164 0.76 22.63 65.47
85 INT11807 Gene_expression of Il2 266 0.78 112 64.97
86 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
87 INT480 Negative_regulation of Localization of Avp 151 0.59 27.64 63.72
88 INT96622 Localization of Trpv1 110 0.81 59.82 63.25
89 INT5095 Localization of Ghrh 185 0.81 28.09 62.08
90 INT6761 Binding of CALCA 100 0.48 26.71 62.05
91 INT7884 Regulation of Localization of Oxt 102 0.62 7.95 61.71
92 INT4760 Negative_regulation of Gene_expression of Calca 93 0.59 34.19 60.3
93 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
94 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74
95 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
96 INT5017 Negative_regulation of Tacr1 76 0.58 17 57.07
97 INT2148 Negative_regulation of Oxt 105 0.59 11.42 57
98 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35
99 INT4241 Regulation of CALCA 87 0.62 28.19 55.29
100 INT49436 Binding of TRPV1 145 0.48 38.35 55.08
101 INT37219 Gene_expression of TACR1 56 0.78 32.4 54.16
102 INT49747 Transcription of Oprm1 68 0.72 9.01 53.78
103 INT4891 Transcription of Calca 81 0.72 35.27 53.75
104 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66
105 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87
106 INT929 Positive_regulation of Oprl1 64 0.70 14.67 52.84
107 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27
108 INT249 Localization of GHRH 215 0.80 78.02 51.87
109 INT97674 Positive_regulation of Localization of Calca 70 0.69 27.71 51.79
110 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34
111 INT12345 Gene_expression of Il2 142 0.78 59.17 51.21
112 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
113 INT8690 Localization of Tac1 71 0.80 22.98 50.75
114 INT4985 Positive_regulation of Tac1 81 0.69 35.79 50.67
115 INT937 Positive_regulation of Oxt 195 0.70 37.82 49.3
116 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
117 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41
118 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
119 INT9383 Localization of TRPV1 98 0.81 33.23 46.24
120 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
121 INT8713 Regulation of Tac1 56 0.60 25.29 45.94
122 INT4776 Localization of TAC1 82 0.78 16.89 45.21
123 INT14853 Negative_regulation of Tac1 80 0.59 30.87 45.06
124 INT1564 Localization of OPRM1 41 0.80 8.03 44.67
125 INT98498 Binding of Trpv1 75 0.48 33.67 44.4
126 INT83953 Gene_expression of Cxcl2 140 0.75 113.07 43.65
127 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8
128 INT1319 Gene_expression of Oprl1 65 0.78 9.34 42.41
129 INT4850 Binding of Tac1 57 0.47 14.25 42.17
130 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
131 INT28265 Positive_regulation of Calca 62 0.70 29.1 41.17
132 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52
133 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
134 INT685 Regulation of AVP 124 0.62 34.9 39.91
135 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
136 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84
137 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
138 INT1596 Negative_regulation of Oprl1 61 0.57 13.5 38.41
139 INT4925 Binding of Tacr1 57 0.48 17.39 38.38
140 INT65125 Gene_expression of Tacr1 81 0.77 23.9 38.35
141 INT58062 Negative_regulation of Gene_expression of Trpv1 66 0.59 22.34 38.02
142 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
143 INT168410 Gene_expression of Cxcr3 81 0.75 84.03 37.01
144 INT80075 Regulation of Gene_expression of Trpv1 55 0.62 32.42 36.88
145 INT4843 Gene_expression of Npff 50 0.78 12.92 36.37
146 INT14137 Localization of Oprm1 56 0.81 2.88 36.09
147 INT8837 Positive_regulation of TAC1 59 0.67 21.94 35.97
148 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79
149 INT77407 Regulation of Gene_expression of OPRM1 51 0.62 12.58 35.75
150 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23
151 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22
152 INT6484 Binding of IL1B 122 0.47 75.84 35.07
153 INT76531 Transcription of Trpv1 62 0.72 23.69 34.77
154 INT4892 Positive_regulation of Gene_expression of Tacr1 56 0.69 25.64 34.69
155 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67
156 INT96624 Positive_regulation of Positive_regulation of Trpv1 62 0.70 20.5 34.28
157 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
158 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15
159 INT48907 Positive_regulation of Gene_expression of Oprm1 53 0.69 8.55 33.52
160 INT8784 Negative_regulation of Positive_regulation of Calca 40 0.59 14.67 33.49
161 INT8746 Negative_regulation of Calca 50 0.59 21.22 33.45
162 INT10763 Localization of IL2 157 0.80 81.11 33.21
163 INT109820 Gene_expression of Trpv4 121 0.78 39.69 33.11
164 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95
165 INT4727 Regulation of TAC1 60 0.47 6.74 32.83
166 INT3117 Regulation of Oxt 103 0.61 17.93 32.28
167 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72
168 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7
169 INT9347 Localization of Il1b 58 0.81 26.13 31.53
170 INT22239 Negative_regulation of TAC1 52 0.57 12.96 31.41
171 INT608 Negative_regulation of KNG1 98 0.43 72.36 31.23
172 INT129207 Gene_expression of Cxcl1 114 0.75 68.54 30.82
173 INT121663 Gene_expression of CXCR3 76 0.77 50.96 30.62
174 INT29477 Transcription of Oprl1 52 0.72 5.05 30.52
175 INT69483 Transcription of OPRM1 45 0.72 7.31 30.22
176 INT5100 Positive_regulation of Ghrh 100 0.64 24.2 30.21
177 INT9993 Positive_regulation of Gene_expression of IL2 131 0.69 46.27 30.04
178 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96
179 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66
180 INT894 Binding of Avp 84 0.48 29.16 29.63
181 INT49431 Phosphorylation of OPRM1 31 0.82 2.2 29.09
182 INT6765 Localization of Oprl1 49 0.81 5.11 28.87
183 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76
184 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
185 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29
186 INT22499 Regulation of Calca 42 0.62 17.32 28.02
187 INT3076 Regulation of KNG1 52 0.60 20.39 27.89
188 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46
189 INT8881 Regulation of Gene_expression of Tacr1 38 0.61 17.49 27.19
190 INT3167 Binding of KNG1 48 0.48 23.26 26.77
191 INT72677 Regulation of Gene_expression of Oprm1 45 0.62 13.95 26.75
192 INT95481 Regulation of Gene_expression of TRPV1 48 0.62 29.3 26.28
193 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
194 INT11773 Gene_expression of Tac1 56 0.77 10 25.72
195 INT112036 Phosphorylation of Trpv1 51 0.82 18.59 25.6
196 INT8779 Binding of TAC1 50 0.47 11.19 25.57
197 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
198 INT103320 Positive_regulation of Positive_regulation of Trpv1 44 0.70 27.73 25.28
199 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2
200 INT92105 Transcription of Trpv1 47 0.71 27.47 25.01
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