GO:0007206

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Name activation of phospholipase C activity by G-protein coupled glutamate receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0007206
Unique Molecular Interactions 34
Total Molecular Interactions 66
Total Single Events 598
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of phospholipase C activity by G-protein coupled glutamate receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for activation of phospholipase C activity by G-protein coupled glutamate receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9
2 INT144115 Positive_regulation of Grm5 Positive_regulation of Prkcg 1 0.41 0 2.01
3 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
4 INT254243 Binding of HOMER1 and MRI1 1 0.03 1.99 1.57
5 INT122268 Binding of Grin2b and Grm5 1 0.40 0.52 1.1
6 INT162250 Binding of TRPV1 and Grm5 1 0.01 0.8 1.03
7 INT157522 GRM5 Regulation of Gene_expression of OPRM1 1 0.28 0 0.97
8 INT210979 Grm5 Positive_regulation of Cysltr1 1 0.00 0.76 0.75
9 INT168911 Grm5 Regulation of Mapk3 1 0.17 0.78 0.71
10 INT282139 Grm1 Regulation of Grip2 1 0.00 0.62 0.69
11 INT282141 Grm5 Regulation of Grip2 1 0.00 0.61 0.69
12 INT148173 Positive_regulation of Grm5 Positive_regulation of Phosphorylation of Mapk1 1 0.01 0.45 0.65
13 INT107523 Negative_regulation of Grm5 Negative_regulation of Gene_expression of Fos 1 0.37 0.09 0.58
14 INT282142 Grm1 Positive_regulation of Positive_regulation of Trib3 1 0.01 0.27 0.57
15 INT159774 Binding of GRM5 and TRPV1 1 0.40 0.5 0.51
16 INT8181 Grm5 Positive_regulation of Gh 1 0.00 0 0.44
17 INT343640 Positive_regulation of Grm5 Positive_regulation of Adp 1 0.01 0 0.4
18 INT128018 Binding of Grm1 and Chi3l4 1 0.01 0.08 0.38
19 INT150196 Grm5 Regulation of Grin2b 1 0.45 0 0.36
20 INT170727 Binding of Grm5 and Calm2 1 0.01 0.13 0.28
21 INT170719 Binding of Grm5 and Siah1a 1 0.01 1.1 0.28
22 INT264841 NAMPT Positive_regulation of GRM5 1 0.01 0.72 0.27
23 INT343641 Grm5 Positive_regulation of Adp 1 0.01 0 0.19
24 INT343644 Grm5 Positive_regulation of Cav2 1 0.05 0 0.19
25 INT265982 Homer1 Regulation of Grm5 1 0.04 0.38 0.12
26 INT347802 Grm5 Positive_regulation of Oss1 1 0.12 0.67 0.11
27 INT265981 Homer1 Regulation of Localization of Grm5 1 0.04 0.06 0.09
28 INT330955 HOMER1 Positive_regulation of Gene_expression of VDR 1 0.01 0.99 0.08
29 INT354971 Binding of HOMER1 and Shank1 1 0.01 0 0.04
30 INT343645 Positive_regulation of Grm5 Positive_regulation of Localization of Car2 1 0.03 0 0
31 INT343639 Grm1 Positive_regulation of Hspg2 1 0.00 0 0
32 INT170726 Negative_regulation of Binding of Grm5 and Calm2 1 0.01 0 0
33 INT343638 Adp Positive_regulation of Positive_regulation of Grm1 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of phospholipase C activity by G-protein coupled glutamate receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in activation of phospholipase C activity by G-protein coupled glutamate receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95789 Positive_regulation of Grm5 42 0.55 20.1 33.72
2 INT51602 Gene_expression of Grm5 59 0.75 17.29 26.99
3 INT78571 Positive_regulation of Grm5 35 0.69 11.81 22.45
4 INT48055 Gene_expression of Grm1 27 0.78 14.29 17.01
5 INT94650 Gene_expression of Grm5 32 0.77 11.26 14.82
6 INT100919 Positive_regulation of Grm1 21 0.70 7.82 11.55
7 INT107522 Regulation of Grm5 9 0.44 6.42 11.46
8 INT82769 Positive_regulation of Grm1 20 0.00 7.78 9.82
9 INT78570 Negative_regulation of Grm5 15 0.57 5.45 9.17
10 INT107657 Positive_regulation of Positive_regulation of Grm5 6 0.69 1.83 8.92
11 INT147498 Gene_expression of GRM5 10 0.75 3.16 7.12
12 INT94649 Gene_expression of Grm1 19 0.77 5.11 6.58
13 INT119132 Regulation of Grm5 8 0.48 2.66 5.46
14 INT113153 Regulation of Grm1 6 0.44 4.11 5.41
15 INT107655 Positive_regulation of Gene_expression of Grm5 6 0.67 5.09 5.06
16 INT100991 Gene_expression of HOMER1 12 0.67 6.96 4.98
17 INT100920 Positive_regulation of Gene_expression of Grm1 7 0.70 5.88 4.87
18 INT91055 Negative_regulation of Grm1 7 0.45 5.14 4.87
19 INT100520 Regulation of Grm1 8 0.44 1.3 4.48
20 INT107390 Negative_regulation of Grm5 11 0.45 6 4.42
21 INT74815 Binding of Grm5 11 0.36 3.62 4.25
22 INT74814 Binding of Grm1 5 0.45 2.69 4.1
23 INT95784 Positive_regulation of Positive_regulation of Grm5 8 0.11 3.48 4.01
24 INT95785 Positive_regulation of Positive_regulation of Grm1 6 0.49 3.59 3.3
25 INT11283 Negative_regulation of Grm1 5 0.57 0.8 2.63
26 INT140206 Binding of GRM5 6 0.36 1.85 2.52
27 INT123713 Binding of Grm5 7 0.31 2.96 2.38
28 INT107656 Regulation of Gene_expression of Grm5 4 0.26 0.84 2.38
29 INT157529 Positive_regulation of GRM5 3 0.48 0.59 2.07
30 INT152025 Negative_regulation of Positive_regulation of Grm5 4 0.14 2.21 2.06
31 INT101945 Regulation of Gene_expression of Grm5 2 0.48 0.96 1.98
32 INT98927 Localization of Grm1 4 0.71 0.42 1.97
33 INT67237 Binding of Grm1 7 0.00 1.49 1.94
34 INT51603 Localization of Grm5 5 0.73 0.33 1.87
35 INT147384 Regulation of Positive_regulation of Grm5 2 0.11 0.41 1.65
36 INT117607 Localization of Grm5 12 0.50 1.31 1.56
37 INT100523 Regulation of GRM5 2 0.26 0.49 1.51
38 INT128391 Positive_regulation of Regulation of Grm5 1 0.37 0 1.49
39 INT152371 Regulation of Gene_expression of Grm1 2 0.42 0.54 1.4
40 INT168906 Positive_regulation of Gene_expression of Grm5 4 0.39 1.75 1.38
41 INT100921 Positive_regulation of Positive_regulation of Grm1 2 0.47 1.01 1.24
42 INT107658 Regulation of Positive_regulation of Grm5 1 0.26 0.84 1.17
43 INT100992 Regulation of Gene_expression of HOMER1 2 0.10 0.74 1.06
44 INT157528 Regulation of Gene_expression of GRM5 1 0.43 0 0.96
45 INT223653 Transcription of Grm5 4 0.69 1.4 0.83
46 INT223641 Transcription of Grm1 3 0.69 1.4 0.83
47 INT120996 Positive_regulation of Gene_expression of Grm1 2 0.00 0.81 0.77
48 INT157526 Regulation of Binding of GRM5 1 0.43 0 0.73
49 INT254244 Localization of HOMER1 1 0.19 0.68 0.66
50 INT168907 Negative_regulation of Negative_regulation of Grm5 1 0.14 1.01 0.65
51 INT353901 Negative_regulation of Negative_regulation of Grm1 1 0.40 0.67 0.61
52 INT91054 Negative_regulation of Gene_expression of Grm1 2 0.36 0.19 0.59
53 INT210972 Positive_regulation of Localization of Grm5 3 0.06 0.24 0.48
54 INT163205 Transcription of Grm5 1 0.00 0.73 0.47
55 INT128595 Negative_regulation of Gene_expression of Grm5 2 0.38 0.51 0.43
56 INT347792 Regulation of Regulation of Grm5 1 0.35 0.12 0.42
57 INT147500 Positive_regulation of Gene_expression of GRM5 1 0.67 0.25 0.33
58 INT86669 Positive_regulation of HOMER1 2 0.30 1.37 0.31
59 INT147499 Negative_regulation of Gene_expression of GRM5 1 0.41 0.29 0.26
60 INT296261 Phosphorylation of Grm1 1 0.02 0.23 0.25
61 INT147383 Regulation of Positive_regulation of Grm1 1 0.44 0.09 0.2
62 INT100990 Positive_regulation of Gene_expression of HOMER1 1 0.17 0.15 0.1
63 INT170678 Negative_regulation of Gene_expression of Grm5 1 0.41 0.07 0.09
64 INT277528 Negative_regulation of Gene_expression of Grm1 1 0.35 0.19 0.09
65 INT223648 Negative_regulation of Transcription of Grm5 1 0.41 0.65 0.08
66 INT223642 Negative_regulation of Transcription of Grm1 1 0.57 0.65 0.08
67 INT277545 Transcription of Grm1 1 0.57 0.09 0.05
68 INT347712 Positive_regulation of Binding of Grm5 1 0.13 0 0.05
69 INT100989 Regulation of HOMER1 1 0.10 0.06 0.04
70 INT300826 Negative_regulation of HOMER1 2 0.37 1.81 0
71 INT300827 Binding of HOMER1 2 0.32 0.28 0
72 INT170708 Protein_catabolism of Grm5 1 0.02 0.08 0
73 INT349192 Transcription of HOMER1 1 0.59 0.06 0
74 INT170703 Positive_regulation of Regulation of Grm5 1 0.01 0 0
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