GO:0007208

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Name activation of phospholipase C activity by serotonin receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0007208
Unique Molecular Interactions 20
Total Molecular Interactions 24
Total Single Events 570
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of phospholipase C activity by serotonin receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for activation of phospholipase C activity by serotonin receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT189299 Atp6v1e1 Positive_regulation of Htr2a 1 0.01 1.01 1.41
2 INT60208 Binding of Htr1a and Htr2c 2 0.52 0.25 1
3 INT129313 HTR2A Positive_regulation of Oxt 1 0.41 0.22 0.67
4 INT261517 Binding of HTR2A and USH1C 1 0.01 0 0.66
5 INT36511 Binding of Htr2a and Eef1a1 1 0.22 0 0.62
6 INT36512 Binding of Htr2a and Man2a2 1 0.19 0 0.62
7 INT47745 Binding of Slc6a4 and Htr2a 1 0.33 0.09 0.52
8 INT74085 Binding of Htr1d and Htr2a 1 0.40 0.65 0.45
9 INT118136 Binding of HTR1A and HTR2A 1 0.36 0.77 0.45
10 INT80205 HTR1B Positive_regulation of Positive_regulation of HTR2A 1 0.54 0 0.33
11 INT66681 Positive_regulation of HTR2A Positive_regulation of Localization of SFTPA1 1 0.22 0.07 0.24
12 INT50886 HTR2A Positive_regulation of HTR1D 1 0.54 0.07 0.2
13 INT261520 Binding of DLG4 and HTR2A 1 0.06 0 0.14
14 INT189301 Atp6v1e1 Positive_regulation of Positive_regulation of Htr2a 1 0.01 1.13 0.11
15 INT174093 Htr2c Regulation of Gene_expression of Csf2 1 0.00 0 0.09
16 INT174070 Htr2c Positive_regulation of Itpr3 1 0.00 0 0.09
17 INT233506 Tlr4 Positive_regulation of Htr2b 1 0.06 0.09 0
18 INT322240 Ace Regulation of Gene_expression of Htr2a 1 0.13 0.63 0
19 INT322254 Agt Regulation of Gene_expression of Htr2a 1 0.15 0.63 0
20 INT322247 Slc6a4 Regulation of Gene_expression of Htr2a 1 0.13 0.63 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of phospholipase C activity by serotonin receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in activation of phospholipase C activity by serotonin receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7000 Positive_regulation of Htr2a 42 0.67 9.48 18.7
2 INT5324 Binding of Htr2a 23 0.47 7.14 14.66
3 INT20071 Positive_regulation of HTR2A 33 0.67 10.89 14
4 INT22272 Negative_regulation of HTR2A 28 0.57 7.62 13.87
5 INT30961 Binding of HTR2A 33 0.47 11.44 12.86
6 INT18001 Positive_regulation of Htr2c 21 0.67 7.63 11.39
7 INT27258 Regulation of Htr2a 18 0.60 6.37 11.06
8 INT11669 Gene_expression of Htr2a 17 0.75 6.78 10.75
9 INT35835 Positive_regulation of Htr2a 17 0.67 10.68 9.81
10 INT16580 Negative_regulation of Htr2a 18 0.57 3.8 9.63
11 INT58841 Gene_expression of HTR2A 33 0.75 9.01 9.07
12 INT56775 Binding of Htr2c 16 0.47 3.77 8.74
13 INT59276 Transcription of Htr2a 12 0.69 10.47 8.25
14 INT27785 Regulation of HTR2A 11 0.44 8 8.18
15 INT9032 Regulation of Htr2c 11 0.60 2.77 7.81
16 INT35452 Gene_expression of Htr2a 11 0.65 5.11 6.1
17 INT49477 Gene_expression of Htr2c 12 0.75 3.26 5.73
18 INT98057 Regulation of Htr2a 9 0.44 5.06 4.28
19 INT52402 Negative_regulation of Htr2c 7 0.42 1.46 4.21
20 INT60667 Transcription of HTR2A 5 0.67 0.44 3.71
21 INT63621 Transcription of Htr2c 6 0.52 0.62 3.49
22 INT55236 Regulation of Htr2c 6 0.44 3.31 3.36
23 INT59275 Positive_regulation of Transcription of Htr2a 6 0.49 4.65 3.34
24 INT35450 Negative_regulation of Htr2a 7 0.47 3.46 3.33
25 INT66617 Localization of HTR2A 6 0.80 1.35 3.32
26 INT54754 Localization of Htr2a 6 0.73 0.73 2.85
27 INT49843 Positive_regulation of Gene_expression of Htr2a 3 0.49 1.53 2.84
28 INT65000 Positive_regulation of Positive_regulation of Htr2c 4 0.67 0.69 2.8
29 INT20593 Positive_regulation of Positive_regulation of Htr2a 6 0.49 1.29 2.55
30 INT62141 Positive_regulation of Gene_expression of HTR2A 8 0.67 2.47 2.42
31 INT20072 Positive_regulation of Positive_regulation of HTR2A 5 0.67 2.96 2.33
32 INT77309 Positive_regulation of Htr2c 3 0.49 2.72 2.25
33 INT64505 Localization of Htr2c 3 0.78 0.87 2.24
34 INT69020 Gene_expression of Htr2c 9 0.74 6.09 2.22
35 INT74088 Negative_regulation of Positive_regulation of Htr2c 1 0.41 0 1.75
36 INT161217 Positive_regulation of Htr2b 1 0.67 2.55 1.58
37 INT189286 Regulation of Gene_expression of Htr2a 1 0.01 1.12 1.49
38 INT189290 Positive_regulation of Positive_regulation of Htr2a 1 0.02 2.51 1.41
39 INT286696 Binding of Htr2a 2 0.35 0.71 1.4
40 INT272340 Transcription of Htr2c 1 0.52 2.77 1.28
41 INT161216 Positive_regulation of Gene_expression of Htr2b 1 0.49 1.87 1.16
42 INT161219 Gene_expression of Htr2b 4 0.75 2.01 1.14
43 INT59274 Positive_regulation of Binding of Htr2a 2 0.67 0.93 1.12
44 INT35451 Negative_regulation of Gene_expression of Htr2a 2 0.35 0.34 1.04
45 INT83857 Negative_regulation of Binding of HTR2A 1 0.42 0.52 0.97
46 INT49842 Regulation of Gene_expression of Htr2a 2 0.44 0.18 0.88
47 INT7001 Negative_regulation of Positive_regulation of Htr2a 2 0.41 0.44 0.86
48 INT125261 Positive_regulation of Gene_expression of Htr2c 2 0.67 2.22 0.7
49 INT272356 Positive_regulation of Transcription of Htr2c 1 0.45 1.66 0.63
50 INT100754 Negative_regulation of Binding of Htr2c 1 0.41 0.49 0.57
51 INT286691 Transcription of Htr2a 1 0.08 0 0.57
52 INT230986 Positive_regulation of Transcription of Htr2c 1 0.45 0.25 0.49
53 INT73215 Negative_regulation of Gene_expression of HTR2A 1 0.41 0.45 0.49
54 INT174055 Negative_regulation of Htr2c 5 0.41 2.63 0.45
55 INT161218 Positive_regulation of Positive_regulation of Htr2b 1 0.67 0.69 0.43
56 INT56465 Regulation of Negative_regulation of Htr2a 1 0.26 0.35 0.4
57 INT344082 Negative_regulation of Localization of HTR2A 1 0.41 0.64 0.37
58 INT58840 Negative_regulation of Negative_regulation of HTR2A 1 0.42 0 0.36
59 INT49289 Negative_regulation of Binding of Htr2a 1 0.41 0 0.35
60 INT211023 Positive_regulation of Gene_expression of Htr2c 2 0.45 2.03 0.33
61 INT34128 Regulation of Binding of Htr2a 1 0.44 0 0.3
62 INT211029 Negative_regulation of Gene_expression of Htr2c 1 0.56 2.54 0.25
63 INT83654 Positive_regulation of Binding of HTR2A 2 0.49 2.08 0.24
64 INT59273 Negative_regulation of Transcription of Htr2a 1 0.42 0.56 0.23
65 INT56466 Positive_regulation of Localization of Htr2a 1 0.45 0.34 0.22
66 INT56464 Regulation of Regulation of Htr2a 1 0.26 0.3 0.21
67 INT50887 Negative_regulation of Positive_regulation of HTR2A 2 0.41 0.07 0.19
68 INT144808 Regulation of Positive_regulation of Htr2a 1 0.44 0.42 0.19
69 INT174049 Positive_regulation of Negative_regulation of Htr2c 1 0.01 0 0.19
70 INT174053 Phosphorylation of Htr2c 1 0.01 0.06 0.18
71 INT272355 Regulation of Regulation of Htr2c 1 0.44 1.1 0.14
72 INT83653 Regulation of Binding of HTR2A 1 0.26 0.78 0.08
73 INT189292 Negative_regulation of Regulation of Htr2a 1 0.02 1.01 0.07
74 INT174050 Binding of Htr2c 1 0.01 0 0.06
75 INT211025 Regulation of Gene_expression of Htr2c 1 0.43 1.01 0.06
76 INT325378 Localization of Htr2a 1 0.78 0.81 0.03
77 INT233451 Negative_regulation of Htr2b 1 0.33 0.09 0
78 INT347593 Negative_regulation of Gene_expression of Htr2b 1 0.01 0.16 0
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