GO:0007214

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Name gamma-aminobutyric acid signaling pathway
Categary Process
Go Slim No
Go Link GO:0007214
Unique Molecular Interactions 101
Total Molecular Interactions 135
Total Single Events 977
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for gamma-aminobutyric acid signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for gamma-aminobutyric acid signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
2 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
3 INT122660 Binding of CACNA1A and DNAH8 2 0.28 2.68 2.08
4 INT355251 Cacna1a Regulation of Gene_expression of Gabrg1 1 0.01 0.06 1.86
5 INT355249 Cacna1a Regulation of Gene_expression of Ltp 1 0.04 0.06 1.86
6 INT355254 Ltp Regulation of Cacna1a 1 0.04 0 1.58
7 INT74843 Binding of Cacna1a and Ea2 3 0.13 3.29 1.55
8 INT112033 Gabrb3 Positive_regulation of Plcg1 1 0.05 0.18 1.49
9 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
10 INT355250 Ltp Regulation of Positive_regulation of Cacna1a 1 0.04 0 1.39
11 INT108727 Binding of ATP1A2 and CACNA1A 2 0.34 1.97 1.37
12 INT122659 Binding of CACNA1A and SAR1B 1 0.06 1.38 1.35
13 INT355253 Ltp Positive_regulation of Cacna1a 1 0.05 0 1.34
14 INT355252 Binding of Cacna1a and Cnr1 1 0.04 0 1.31
15 INT74841 Binding of Cacna1a and Ea2 2 0.01 2.33 1.27
16 INT247924 Slc12a5 Regulation of Gene_expression of Slc12a2 1 0.25 1.43 1.23
17 INT247925 Slc12a2 Regulation of Cl 1 0.01 1.44 1.23
18 INT123260 Binding of Gabrg2 and Serpini1 1 0.02 0.63 1.16
19 INT123261 Gabrg2 Regulation of Serpini1 1 0.01 0.63 1.16
20 INT119887 Binding of Atf4 and Usf1 1 0.21 0.15 1.05
21 INT108729 Binding of CACNA1A and Cacna1a 3 0.13 1.21 0.95
22 INT244396 Binding of Cl and Slc12a2 1 0.03 0.88 0.76
23 INT19577 Gabrg1 Negative_regulation of Got1 1 0.04 0.16 0.74
24 INT214410 Binding of ATP1A4 and CACNA1A 1 0.26 0.95 0.7
25 INT31416 Cacna1a Positive_regulation of Gene_expression of Gcg 1 0.03 0 0.65
26 INT296169 Binding of Htr4 and Creb1 1 0.49 0.1 0.56
27 INT164971 Binding of Rgs7 and Gnai2 1 0.01 0 0.54
28 INT164970 Binding of Rgs8 and Gnai2 1 0.01 0 0.53
29 INT354986 Cacna1a Regulation of Localization of Mpo 1 0.01 1.15 0.49
30 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
31 INT72016 Positive_regulation of Binding of Gnai2 and Ptprg 1 0.02 0 0.44
32 INT155752 Binding of CACNA1A and ATCAY 1 0.04 0.86 0.42
33 INT72018 Binding of Gnai2 and Ptprg 1 0.01 0 0.41
34 INT241679 EIF2AK3 Positive_regulation of Atf4 1 0.06 0.46 0.4
35 INT354984 Binding of Cacna1a and Tnf 1 0.01 0.83 0.4
36 INT158355 Cacna1a Regulation of Alox5 1 0.01 0.7 0.37
37 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34
38 INT354982 Cacna1a Regulation of Tnf 1 0.00 0.73 0.34
39 INT161996 Binding of Gabbr2 and Fbxo23 1 0.29 0.15 0.33
40 INT101551 Binding of CACNA1A and CACNA1F 1 0.07 1.51 0.33
41 INT151258 Binding of Cacna1a and FCMTE1 1 0.00 0.57 0.3
42 INT132585 GABBR1 Positive_regulation of Binding of Gabbr1 1 0.01 0.6 0.3
43 INT141438 Gnai2 Positive_regulation of Localization of ADCY1 1 0.01 0.43 0.29
44 INT244034 Binding of Gabrg2 and Ubqln1 1 0.01 0.09 0.26
45 INT142003 Binding of Cacna1a and Etax2 1 0.00 1.02 0.26
46 INT142004 Binding of Cacna1a and TGM6 1 0.00 1.02 0.26
47 INT318678 Atf4 Positive_regulation of Gene_expression of Ddit3 1 0.53 0.77 0.23
48 INT244047 Binding of Gabrg2 and Myoz1 1 0.00 0.19 0.23
49 INT356231 Binding of Gabrb3 and Gad1 1 0.32 1.25 0.23
50 INT318679 Atf4 Positive_regulation of Gene_expression of Xbp1 1 0.53 0.77 0.23
51 INT72015 Binding of Adora2a and Gnai2 1 0.01 0 0.21
52 INT121807 CACNA1A Regulation of CAV2 1 0.01 0.25 0.2
53 INT318682 Atf4 Positive_regulation of Ddit3 1 0.73 1.71 0.18
54 INT244038 Binding of Gabrg2 and Gabarap 1 0.08 0.24 0.18
55 INT320260 Binding of Atf4 and Creb1 1 0.15 0.36 0.17
56 INT320256 Binding of Atf4 and Rorb 1 0.06 0.36 0.17
57 INT320263 Binding of Ntrk2 and Atf4 1 0.01 0.38 0.17
58 INT261518 Binding of DLG4 and HTR4 1 0.01 0 0.16
59 INT71329 Cacna1a Regulation of Ea2 1 0.01 0.71 0.15
60 INT71328 Cacna1a Regulation of Atxn2 1 0.00 0.71 0.15
61 INT156057 UMOD Regulation of GABRG3 1 0.01 0.54 0.14
62 INT261519 Binding of HTR4 and USH1C 1 0.00 0 0.13
63 INT328143 Gabrb3 Positive_regulation of Ube3a 1 0.56 0.99 0.11
64 INT276061 Gabbr2 Negative_regulation of Prkaca 1 0.09 0 0.11
65 INT328146 Gabrb3 Negative_regulation of Ube3a 1 0.48 0.99 0.11
66 INT120559 Binding of Cacna1a and FCMTE1 1 0.02 0.25 0.1
67 INT276041 Positive_regulation of Gabbr2 Negative_regulation of Positive_regulation of Rpa1 1 0.01 0 0.1
68 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09
69 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09
70 INT196213 REST Regulation of Gene_expression of CACNA1A 1 0.46 0.08 0.08
71 INT215879 Ddit3 Regulation of Regulation of Atf4 1 0.26 0.29 0.07
72 INT273947 Binding of Gabra1 and Mrvi1 1 0.00 0.94 0.07
73 INT273937 Binding of Crem and Gabra1 1 0.30 0.94 0.07
74 INT215877 Atf4 Regulation of Eif2ak3 1 0.44 0.21 0.06
75 INT244048 Binding of Gabrg2 and Gabarapl1 1 0.02 0.19 0.05
76 INT244031 Binding of Gabrg2 and Nsf 1 0.04 0.19 0.05
77 INT284447 Il11 Positive_regulation of Atf4 1 0.01 0.42 0.05
78 INT215876 Atf4 Regulation of Hspa5 1 0.22 0.43 0.04
79 INT215871 Atf4 Regulation of Ddit3 1 0.26 0.43 0.04
80 INT354983 Cacna1a Regulation of Mpo 1 0.02 0.41 0.04
81 INT215882 Atf4 Regulation of Xbp1 1 0.28 0.43 0.04
82 INT215875 Atf4 Regulation of Mapkap1 1 0.29 0.43 0.04
83 INT354987 Cacna1a Regulation of Localization of LDHA 1 0.00 0.23 0.03
84 INT215872 Atf4 Regulation of Esr1 1 0.30 0.42 0.03
85 INT196208 REST Regulation of CACNA1A 1 0.46 0.06 0
86 INT196216 Binding of CACNA1A and REST 1 0.28 0 0
87 INT261963 Binding of Cacna1a and Tgm2 1 0.08 1.19 0
88 INT206943 Hspa5 Positive_regulation of Atf4 1 0.47 0.62 0
89 INT276066 Gabbr2 Negative_regulation of Positive_regulation of Rpa1 1 0.01 0 0
90 INT250496 Gopc Regulation of Positive_regulation of Cacna1a 1 0.37 0 0
91 INT328141 Binding of Chrne and Gabrb3 1 0.41 0.08 0
92 INT209708 Binding of GABBR1 and GTPBP4 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for gamma-aminobutyric acid signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in gamma-aminobutyric acid signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
2 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
3 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2
4 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35
5 INT100115 Gene_expression of Slc12a2 34 0.76 39.15 15.69
6 INT30101 Regulation of Cacna1a 25 0.45 14.38 12.43
7 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91
8 INT62014 Negative_regulation of Slc12a2 17 0.49 12.85 8.99
9 INT138889 Positive_regulation of Slc12a2 23 0.65 18.53 8.85
10 INT68267 Gene_expression of CACNA1A 22 0.75 11.39 8.65
11 INT94356 Regulation of Slc12a2 11 0.58 12.8 6.59
12 INT91821 Binding of Cacna1a 16 0.48 13.1 6.37
13 INT206950 Positive_regulation of Atf4 14 0.45 7.02 5.71
14 INT129508 Localization of Cacna1a 7 0.74 6.47 5.13
15 INT110796 Positive_regulation of Positive_regulation of Cacna1a 1 0.49 0.51 4.84
16 INT244386 Positive_regulation of Gene_expression of Slc12a2 10 0.58 18.39 4.5
17 INT117244 Gene_expression of GABBR1 5 0.33 2.19 4.36
18 INT82731 Transcription of Cacna1a 5 0.56 3.41 4.27
19 INT70739 Gene_expression of Gabrg2 11 0.75 4.15 4.18
20 INT287526 Negative_regulation of Gene_expression of CACNA1A 1 0.42 4.25 3.81
21 INT63625 Gene_expression of HTR4 3 0.65 3.37 3.73
22 INT54840 Localization of HTR4 6 0.73 2.67 3.42
23 INT85288 Gene_expression of Gabbr2 5 0.76 2.39 3.41
24 INT53516 Binding of CACNA1A 9 0.47 6.86 3.36
25 INT94045 Regulation of Cacna1a 5 0.42 3.56 3.33
26 INT78317 Regulation of CACNA1A 8 0.62 7.68 3.08
27 INT85572 Gene_expression of Cacna1a 11 0.66 5.72 3.02
28 INT142940 Positive_regulation of Negative_regulation of Cacna1a 3 0.50 1.65 2.97
29 INT70738 Negative_regulation of Gabrg2 7 0.57 4 2.96
30 INT241623 Gene_expression of Atf4 12 0.74 8.67 2.85
31 INT63902 Positive_regulation of Htr4 7 0.67 0.71 2.84
32 INT48688 Positive_regulation of HTR4 12 0.67 1.94 2.81
33 INT54495 Binding of GABBR1 9 0.35 1.82 2.76
34 INT244385 Phosphorylation of Slc12a2 12 0.77 4.67 2.74
35 INT163528 Gene_expression of Gabra1 3 0.74 0.75 2.73
36 INT74716 Negative_regulation of Htr4 4 0.42 2.17 2.72
37 INT355244 Negative_regulation of Negative_regulation of Cacna1a 1 0.04 0 2.67
38 INT138891 Regulation of Gene_expression of Slc12a2 5 0.58 4.83 2.64
39 INT33145 Binding of Gabbr2 1 0.48 0.98 2.48
40 INT72013 Negative_regulation of Gnai2 5 0.35 0.09 2.44
41 INT80926 Regulation of HTR4 4 0.60 1.85 2.36
42 INT114773 Negative_regulation of GABBR1 4 0.43 0.55 2.33
43 INT33147 Positive_regulation of Gabbr2 4 0.50 0.32 2.32
44 INT74361 Negative_regulation of Gabrb3 4 0.58 0.73 2.28
45 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26
46 INT55658 Binding of HTR4 8 0.47 2.14 2.19
47 INT241581 Regulation of Htr4 6 0.44 1.34 2.19
48 INT110795 Regulation of Positive_regulation of Cacna1a 2 0.26 0.65 2.07
49 INT63901 Positive_regulation of Positive_regulation of Htr4 2 0.49 0.3 1.93
50 INT29831 Positive_regulation of Gabbr2 2 0.26 0.5 1.88
51 INT247918 Positive_regulation of Positive_regulation of Slc12a2 1 0.39 2.55 1.86
52 INT354979 Positive_regulation of Localization of Cacna1a 2 0.05 0.86 1.79
53 INT355239 Negative_regulation of Positive_regulation of Cacna1a 1 0.04 0 1.79
54 INT71327 Localization of Cacna1a 3 0.60 2.51 1.7
55 INT244392 Binding of Slc12a2 3 0.35 2.05 1.68
56 INT33144 Positive_regulation of Binding of Gabbr2 1 0.69 0.65 1.63
57 INT85289 Positive_regulation of Gene_expression of Gabbr2 2 0.49 0.75 1.6
58 INT48775 Regulation of Gabbr2 3 0.41 0.15 1.55
59 INT72008 Gene_expression of Gnai2 4 0.38 0.42 1.49
60 INT74360 Gene_expression of Gabrb3 2 0.77 3.85 1.49
61 INT355242 Negative_regulation of Binding of Cacna1a 1 0.04 0.17 1.47
62 INT241618 Regulation of Atf4 3 0.43 1.41 1.46
63 INT355245 Regulation of Localization of Cacna1a 1 0.04 0 1.43
64 INT96372 Gene_expression of Gabbr2 4 0.45 0.22 1.42
65 INT241627 Regulation of Positive_regulation of Atf4 1 0.29 0.36 1.4
66 INT119870 Binding of Atf4 1 0.45 0.39 1.39
67 INT90740 Negative_regulation of Cacna1a 3 0.23 1.43 1.38
68 INT241624 Positive_regulation of Positive_regulation of Atf4 1 0.32 0.72 1.32
69 INT82727 Positive_regulation of Transcription of Cacna1a 1 0.01 1.07 1.25
70 INT96373 Negative_regulation of Gene_expression of Gabbr2 1 0.06 0 1.22
71 INT1867 Positive_regulation of GABBR1 6 0.69 0.55 1.18
72 INT85571 Positive_regulation of Cacna1a 3 0.50 2.06 1.18
73 INT355243 Negative_regulation of Regulation of Cacna1a 1 0.04 0 1.16
74 INT163527 Positive_regulation of Gene_expression of Gabra1 1 0.31 0.16 1.15
75 INT118632 Binding of Gabbr2 2 0.32 0.25 1.12
76 INT244393 Positive_regulation of Phosphorylation of Slc12a2 1 0.65 1.92 1.12
77 INT54505 Binding of Gabra1 2 0.35 0.45 1.1
78 INT149656 Negative_regulation of Gene_expression of Slc12a2 3 0.38 2.36 1.02
79 INT119214 Transcription of Gnai2 1 0.44 0.06 0.96
80 INT321650 Negative_regulation of Gene_expression of Cacna1a 2 0.04 0.13 0.95
81 INT63624 Transcription of HTR4 1 0.52 0.44 0.94
82 INT94046 Protein_catabolism of Cacna1a 1 0.70 0.83 0.9
83 INT241620 Negative_regulation of Positive_regulation of Atf4 1 0.27 0.85 0.88
84 INT119213 Positive_regulation of Gnai2 1 0.42 0.06 0.88
85 INT33146 Negative_regulation of Binding of Gabbr2 1 0.43 0.33 0.86
86 INT131964 Positive_regulation of CACNA1A 5 0.61 0.73 0.85
87 INT318665 Negative_regulation of Gene_expression of Atf4 1 0.56 5.16 0.85
88 INT85290 Regulation of Gene_expression of Gabbr2 1 0.44 0.74 0.8
89 INT100639 Regulation of Gabbr2 1 0.45 0.4 0.75
90 INT118566 Gene_expression of Atf4 4 0.64 2.58 0.73
91 INT117246 Transcription of GABBR1 1 0.38 0.07 0.72
92 INT103336 Transcription of Cacna1a 2 0.69 1.17 0.68
93 INT118563 Regulation of Gene_expression of Atf4 1 0.37 0.89 0.68
94 INT141227 Phosphorylation of CACNA1A 1 0.55 0.78 0.66
95 INT264628 Regulation of GABBR1 3 0.26 1.39 0.62
96 INT344760 Gene_expression of GABRG3 1 0.36 0.41 0.62
97 INT274331 Gene_expression of Htr4 2 0.58 0 0.61
98 INT62881 Positive_regulation of Positive_regulation of HTR4 2 0.49 0.96 0.59
99 INT241625 Regulation of Gene_expression of Atf4 2 0.43 0.83 0.59
100 INT74362 Regulation of Gabrb3 1 0.28 0 0.58
101 INT243940 Binding of Gabrg2 2 0.47 0.88 0.56
102 INT189813 Negative_regulation of CACNA1A 4 0.57 3.07 0.55
103 INT122930 Positive_regulation of Gene_expression of CACNA1A 2 0.49 0.91 0.54
104 INT39251 Negative_regulation of Gabrg1 1 0.06 0 0.53
105 INT163526 Regulation of Gene_expression of Gabra1 1 0.16 0.16 0.52
106 INT86339 Positive_regulation of Gabrb3 1 0.14 0.14 0.51
107 INT148391 Positive_regulation of Gabrg2 3 0.45 0.31 0.5
108 INT241626 Negative_regulation of Regulation of Atf4 1 0.28 0.29 0.48
109 INT161878 Negative_regulation of Gene_expression of Gabrg2 2 0.57 0.75 0.4
110 INT72014 Negative_regulation of Gene_expression of Gnai2 1 0.24 0 0.4
111 INT99962 Positive_regulation of Gene_expression of Cacna1a 1 0.01 1.1 0.34
112 INT155753 Regulation of Gene_expression of CACNA1A 1 0.27 0.66 0.32
113 INT100114 Localization of Slc12a2 3 0.73 2.02 0.31
114 INT70737 Transcription of Gabrg2 3 0.52 0.67 0.31
115 INT244383 Transcription of Slc12a2 2 0.67 0.82 0.29
116 INT328133 Localization of Gabrb3 1 0.75 1.35 0.27
117 INT247915 Regulation of Positive_regulation of Gabrg2 1 0.26 0.08 0.25
118 INT318676 Negative_regulation of Atf4 3 0.56 1.59 0.23
119 INT356219 Binding of Gabrb3 1 0.29 1.25 0.23
120 INT244389 Negative_regulation of Positive_regulation of Slc12a2 1 0.40 0.4 0.2
121 INT227588 Negative_regulation of HTR4 1 0.02 0.12 0.18
122 INT275363 Negative_regulation of Gabbr2 1 0.04 1.82 0.18
123 INT276015 Regulation of Positive_regulation of Gabbr2 1 0.14 0.41 0.16
124 INT318139 Regulation of Gene_expression of Gabrg2 1 0.44 0.87 0.16
125 INT328139 Negative_regulation of Gene_expression of Gabrb3 1 0.43 0.1 0.15
126 INT215846 Positive_regulation of Atf4 3 0.58 2.03 0.12
127 INT318674 Transcription of Atf4 3 0.69 1.26 0.1
128 INT260469 Localization of Gabbr2 1 0.43 0.11 0.1
129 INT260453 Negative_regulation of Localization of Gabbr2 1 0.25 0.12 0.1
130 INT331160 Localization of GABBR1 1 0.17 0.07 0.09
131 INT275365 Negative_regulation of Gene_expression of Gabbr2 1 0.04 0.91 0.09
132 INT196235 Negative_regulation of Transcription of CACNA1A 1 0.36 0.1 0.07
133 INT215869 Regulation of Atf4 1 0.26 0.29 0.07
134 INT196229 Transcription of CACNA1A 1 0.60 0.24 0.07
135 INT191565 Localization of Htr4 1 0.68 0.07 0.06
136 INT293109 Positive_regulation of Transcription of Slc12a2 1 0.10 0.35 0.05
137 INT309389 Phosphorylation of Cacna1a 1 0.01 0.54 0.05
138 INT309386 Positive_regulation of Phosphorylation of Cacna1a 1 0.01 0.54 0.05
139 INT318669 Localization of Atf4 1 0.72 0.58 0.05
140 INT318672 Positive_regulation of Transcription of Atf4 1 0.48 0.52 0.05
141 INT241629 Phosphorylation of Atf4 1 0.52 0.08 0.04
142 INT276020 Negative_regulation of Positive_regulation of Gabbr2 1 0.13 0 0.04
143 INT243921 Regulation of Gabrg2 1 0.08 0.18 0.03
144 INT215843 Negative_regulation of Atf4 1 0.36 0.39 0.03
145 INT261549 Positive_regulation of Gene_expression of HTR4 1 0.05 0.1 0
146 INT320251 Regulation of Transcription of Atf4 1 0.43 0.25 0
147 INT328126 Positive_regulation of Gene_expression of Gabrb3 1 0.50 1.08 0
148 INT321996 Positive_regulation of Regulation of GABBR1 1 0.45 0 0
149 INT328138 Protein_catabolism of Gabrb3 1 0.88 0 0
150 INT276005 Positive_regulation of Gene_expression of Gabbr2 1 0.16 0 0
151 INT293100 Regulation of Positive_regulation of Slc12a2 1 0.08 0.19 0
152 INT196237 Positive_regulation of Transcription of CACNA1A 1 0.39 0.14 0
153 INT262121 Localization of Gabbr2 1 0.01 0.14 0
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