GO:0007218

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Name neuropeptide signaling pathway
Categary Process
Go Slim No
Go Link GO:0007218
Unique Molecular Interactions 3628
Total Molecular Interactions 5461
Total Single Events 60999
Pain Genes Associated 125

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for neuropeptide signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for neuropeptide signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4
2 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
3 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
4 INT6078 Pomc Positive_regulation of Localization of Penk 13 0.51 0 15.49
5 INT69886 Ngf Positive_regulation of Calca 8 0.76 2.98 12.77
6 INT166591 Binding of CALCA and DCLK3 4 0.30 0.69 12.18
7 INT10161 Binding of Cck and Penk 6 0.53 0.97 11.15
8 INT10268 Binding of PDYN and POMC 11 0.39 0.08 10.36
9 INT68514 Pnoc Positive_regulation of Oprl1 10 0.59 3.56 9.57
10 INT6079 Pomc Positive_regulation of Penk 9 0.43 0 9.46
11 INT65724 Binding of Pnoc and Oprl1 8 0.33 2.94 8.82
12 INT21276 Binding of Oprd1 and Penk 9 0.54 1.14 8.28
13 INT2714 Pomc Positive_regulation of Localization of Prl 17 0.79 0.5 8.18
14 INT180785 Gdnf Positive_regulation of Calca 1 0.23 1.96 8.04
15 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8
16 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
17 INT140015 Avp Positive_regulation of Localization of Penk 3 0.63 3.48 6.63
18 INT26824 Crh Positive_regulation of Localization of Penk 7 0.54 0.42 6.49
19 INT31439 Penk Positive_regulation of Localization of Prl 8 0.55 0.23 6.24
20 INT91538 Pomc Positive_regulation of P9Ehs1 6 0.11 1.47 6.23
21 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
22 INT92466 Pomc Positive_regulation of Binding of Crygs 8 0.06 0 5.56
23 INT126335 Binding of Pax3 and Tac1 6 0.07 6.22 5.27
24 INT9546 Binding of Adarb1 and Penk 5 0.03 0 5.1
25 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05
26 INT1310 Pomc Regulation of Localization of Prl 9 0.40 0.61 4.96
27 INT69888 Ngf Positive_regulation of Localization of Calca 4 0.52 0.51 4.95
28 INT102122 Binding of Calca and RT1-M4 7 0.29 5.83 4.94
29 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
30 INT44716 Binding of ABL2 and PDYN 2 0.40 0.66 4.77
31 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68
32 INT24742 Binding of Calca and Vip 1 0.37 0.18 4.68
33 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
34 INT38217 Penk Regulation of Localization of Avp 2 0.38 0.56 4.45
35 INT30423 Penk Regulation of Localization of Ins1 4 0.26 0.77 4.42
36 INT36536 PRSS1 Positive_regulation of PENK 1 0.24 0.86 4.39
37 INT64480 Binding of OPRL1 and PNOC 2 0.33 0.23 4.38
38 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
39 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
40 INT1313 Pomc Positive_regulation of Prl 7 0.35 0 4.19
41 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 0.30 0.91 4.18
42 INT128998 Cxcl1 Positive_regulation of Localization of Calca 1 0.66 2.96 4.15
43 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
44 INT31440 Penk Positive_regulation of Prl 7 0.76 0 4.1
45 INT29240 Binding of POMC and YY1 5 0.40 0.17 4.06
46 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
47 INT2169 Penk Regulation of Localization of Prl 6 0.48 0 4.03
48 INT13969 Binding of Calca and Sst 3 0.32 0.6 4.02
49 INT138959 Dbi Positive_regulation of Penk 1 0.01 3.05 3.99
50 INT20456 Binding of Pomc and Penk 9 0.41 0.26 3.93
51 INT13966 Calca Positive_regulation of Localization of Sst 5 0.49 0.75 3.91
52 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
53 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
54 INT249566 Binding of Oprd1 and Psmd1 1 0.01 0.82 3.8
55 INT85541 Ngf Positive_regulation of Gene_expression of Calca 2 0.55 1.84 3.71
56 INT34534 Binding of Penk and Oprl1 4 0.37 0 3.64
57 INT18026 Binding of Oprd1 and Oprm1 4 0.40 0.83 3.53
58 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52
59 INT87491 CALCA Positive_regulation of Gene_expression of IL8 1 0.72 0.92 3.52
60 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
61 INT24710 Binding of Calca and SUB1P1 1 0.01 2.09 3.48
62 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
63 INT108473 Binding of ADCYAP1 and PNOC 1 0.32 0.64 3.41
64 INT69770 Penk Negative_regulation of Pscs 1 0.11 0.22 3.39
65 INT212658 KCNA1 Positive_regulation of Cort 1 0.00 2.58 3.36
66 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35
67 INT7436 CFP Positive_regulation of Binding of POMC 1 0.02 0.18 3.35
68 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
69 INT182704 Binding of NPFF and TP53INP2 1 0.01 0.73 3.28
70 INT108472 Binding of NOS1 and PNOC 1 0.32 0.64 3.27
71 INT108471 Binding of CALCA and PNOC 1 0.29 0.64 3.25
72 INT74159 Ngf Regulation of Gene_expression of Calca 2 0.60 1.66 3.22
73 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
74 INT18793 Crh Regulation of Localization of Penk 1 0.59 0 3.2
75 INT34294 Penk Positive_regulation of Localization of Crh 1 0.16 0.43 3.19
76 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17
77 INT29657 Binding of Calca and Calcb 1 0.26 0 3.16
78 INT17456 Binding of CSF2 and POMC 3 0.32 4.06 3.15
79 INT6076 Negative_regulation of Pomc Positive_regulation of Penk 3 0.31 0 3.14
80 INT128513 Pnoc Regulation of Adarb1 1 0.01 0.92 3.14
81 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 3 0.00 0.63 3.1
82 INT30424 Penk Regulation of Localization of Sst 1 0.20 0 3.1
83 INT81708 POMC Regulation of Gene_expression of ITGAM 1 0.53 0.72 3.1
84 INT36535 PRSS1 Positive_regulation of Regulation of PENK 1 0.23 0.54 3.06
85 INT26677 Penk Regulation of Localization of Trh 5 0.50 0 3.05
86 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
87 INT106338 Positive_regulation of Tacr1 Positive_regulation of Localization of Abat 5 0.34 0 3.01
88 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
89 INT40660 Pdyn Positive_regulation of Localization of Prl 1 0.27 0 3.01
90 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01
91 INT100835 Binding of Calca and Akap12 1 0.07 0.41 2.92
92 INT41152 Binding of Penk and Slc3a1 3 0.12 0.11 2.91
93 INT166592 Binding of CALCA and RAMP1 2 0.35 0.33 2.91
94 INT73821 CALCA Positive_regulation of Localization of IL8 1 0.25 2.37 2.91
95 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9
96 INT194409 Binding of CALCA and IGKV1D-8 1 0.15 0 2.84
97 INT32656 Pomc Positive_regulation of Rbm39 1 0.08 0.42 2.84
98 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
99 INT169134 Binding of Calca and Trpa1 1 0.37 3.37 2.79
100 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78
101 INT137230 Trh Regulation of Gene_expression of Oprd1 1 0.01 1.62 2.75
102 INT23280 PRSS1 Positive_regulation of Penk 1 0.05 1.53 2.74
103 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
104 INT180779 Bdnf Regulation of Calca 1 0.09 0.23 2.71
105 INT30133 Binding of Cck and Penk 1 0.27 2.49 2.71
106 INT134294 Binding of Pdyn and Penk 1 0.23 0 2.69
107 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
108 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
109 INT70946 Penk Positive_regulation of Hpse 1 0.34 0 2.65
110 INT150457 Binding of Sort1 and Prss12 3 0.21 1.36 2.64
111 INT30345 Pomc Regulation of Localization of Penk 3 0.31 0 2.61
112 INT53648 Acot1 Positive_regulation of Localization of Calca 2 0.23 0 2.61
113 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59
114 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58
115 INT111789 Cck Regulation of Gene_expression of Penk 1 0.49 1.68 2.57
116 INT70757 Binding of Oprl1 and Pnoc 5 0.03 0.23 2.55
117 INT111786 Penk Regulation of Gene_expression of Cck 1 0.49 1.66 2.55
118 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
119 INT57624 Calca Regulation of Positive_regulation of Trh 1 0.50 0 2.53
120 INT48526 Binding of Calca and Penk 1 0.24 1.03 2.51
121 INT69665 Binding of Oprd1 and Pnoc 5 0.35 0.4 2.5
122 INT249567 Positive_regulation of Binding of Oprd1 and Psmd1 1 0.01 0.66 2.5
123 INT130284 Ins1 Negative_regulation of Gene_expression of Npy 1 0.32 0.1 2.47
124 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46
125 INT14687 Binding of Penk and Ppt1 1 0.41 0 2.46
126 INT21520 Crh Regulation of Pomc 3 0.22 0.4 2.45
127 INT96462 Pnoc Positive_regulation of Pag1 1 0.01 0.74 2.45
128 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
129 INT136129 Calca Positive_regulation of ATP8A2 1 0.38 0.89 2.4
130 INT214144 Cck Positive_regulation of Pomc 1 0.15 0.94 2.39
131 INT96465 Pnoc Positive_regulation of GEM 1 0.01 0.74 2.39
132 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
133 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
134 INT13967 Calca Positive_regulation of Sst 1 0.45 0 2.3
135 INT76776 Binding of Pnoc and Ptprg 2 0.02 0 2.29
136 INT152900 TRPV1 Regulation of Gene_expression of CALCA 1 0.69 0.73 2.29
137 INT152901 TRPV1 Regulation of Localization of CALCA 1 0.44 0.73 2.29
138 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
139 INT91860 Npy Regulation of Npy1r 2 0.28 1.13 2.24
140 INT51317 Binding of POMC and OR5D2P 1 0.00 0.6 2.23
141 INT34310 CRH Positive_regulation of POMC 3 0.42 0.62 2.21
142 INT69887 Ngf Regulation of Calca 2 0.49 0.1 2.19
143 INT32586 H2-Ab1 Regulation of Pomc 1 0.03 0.14 2.19
144 INT1315 Pomc Positive_regulation of Localization of Gnrhr 3 0.38 0.16 2.16
145 INT5486 Oprd1 Regulation of Cck 1 0.21 0 2.16
146 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
147 INT18791 Crh Regulation of Penk 2 0.49 0 2.15
148 INT39108 Binding of PDYN and YY1 2 0.50 0.44 2.14
149 INT135035 Binding of Hk1 and Tac1 1 0.35 0.18 2.14
150 INT79470 Mgat4a Regulation of Localization of Calca 1 0.08 1.72 2.1
151 INT89733 Binding of Calca and Nrm 1 0.31 0.71 2.09
152 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
153 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
154 INT28387 Pomc Positive_regulation of Localization of LH 2 0.40 0.28 2.07
155 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
156 INT161187 NMS Regulation of Gene_expression of Ntrk2 1 0.43 3.05 2.06
157 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
158 INT63873 SRPX Positive_regulation of Localization of Calca 1 0.02 0.49 2.04
159 INT18355 Penk Positive_regulation of Localization of Sst 1 0.31 0 2.04
160 INT115042 Gdnf Regulation of Calca 1 0.53 0.25 2.03
161 INT26221 Calca Regulation of Gt(pU21)50Imeg 1 0.01 0 2.02
162 INT117821 Binding of Tacr1 and Cd4 1 0.34 0.86 2.02
163 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
164 INT138962 Dbi Positive_regulation of Pomc 1 0.00 1.53 2
165 INT32585 H2-Ab1 Negative_regulation of Pomc 1 0.03 0.13 2
166 INT21261 Penk Negative_regulation of Npr1 1 0.02 0 2
167 INT128996 Ccl2 Positive_regulation of Localization of Calca 1 0.68 1.43 2
168 INT60626 Crh Positive_regulation of Localization of Pomc 7 0.54 2.3 1.99
169 INT26948 Pomc Positive_regulation of Localization of Gh1 2 0.22 0.15 1.99
170 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99
171 INT23755 Mptp1 Regulation of PDYN 1 0.01 2.27 1.98
172 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
173 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
174 INT58678 Binding of Penk and Abat 2 0.40 1.39 1.97
175 INT2653 Slc3a1 Regulation of Penk 3 0.04 0.37 1.96
176 INT122381 Positive_regulation of Pnoc Positive_regulation of Oprl1 1 0.36 1.11 1.96
177 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
178 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
179 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
180 INT68272 Binding of Oprd1 and G2e3 1 0.00 0.11 1.93
181 INT37882 Penk Positive_regulation of LOC100366054 1 0.08 0.35 1.93
182 INT65025 Binding of Oprm1 and Hps4 1 0.01 0 1.93
183 INT153533 NMS Regulation of Gene_expression of Ephb1 1 0.48 3.96 1.93
184 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92
185 INT6931 Binding of Oprk1 and Pdyn 2 0.24 0.92 1.92
186 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
187 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
188 INT30146 Binding of Adarb1 and Pdyn 1 0.01 0.17 1.91
189 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
190 INT31438 Penk Positive_regulation of Localization of Pomc 1 0.18 0 1.9
191 INT169498 Binding of Oprm1 and Mirlet7a-1 1 0.32 0 1.9
192 INT24942 Calca Regulation of TAC1 1 0.13 0.7 1.89
193 INT271408 NGF Positive_regulation of Gene_expression of CALCA 1 0.09 4.89 1.88
194 INT153582 Binding of Oprm1 and Hint1 1 0.01 0 1.87
195 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 0.06 1.02 1.87
196 INT211747 Negative_regulation of Binding of Oprm1 and Mors1 1 0.09 0 1.86
197 INT29996 Binding of Oprm1 and Penk 2 0.36 0.4 1.85
198 INT75069 Penk Regulation of Gene_expression of Pkhd1l1 1 0.09 0 1.85
199 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
200 INT168723 Positive_regulation of Trpv1 Positive_regulation of Gene_expression of Calca 1 0.48 1.1 1.84

Single Events

The table below shows the top 100 pain related interactions that have been reported for neuropeptide signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in neuropeptide signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 2008 0.81 518.3 1408.65
2 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59
3 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84
4 INT292 Localization of Penk 876 0.81 88.44 669.14
5 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87
6 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08
7 INT797 Regulation of Penk 812 0.62 111.13 542.24
8 INT443 Localization of POMC 1020 0.81 284.52 443.17
9 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04
10 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
11 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16
12 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81
13 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38
14 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83
15 INT5660 Binding of Oprd1 477 0.48 71.86 342.06
16 INT2649 Regulation of Calca 433 0.62 146.05 330.95
17 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32
18 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
19 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41
20 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98
21 INT1396 Binding of Penk 355 0.48 22.79 269.65
22 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9
23 INT738 Regulation of POMC 459 0.62 111.19 243.74
24 INT5597 Gene_expression of Pdyn 433 0.78 62.97 235.47
25 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45
26 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
27 INT626 Localization of CALCA 289 0.81 125.39 221.15
28 INT1308 Localization of Pomc 457 0.81 66.83 217.5
29 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92
30 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24
31 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07
32 INT1652 Regulation of Pomc 387 0.62 61.01 186.51
33 INT4803 Transcription of Penk 435 0.72 59.09 182.4
34 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
35 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65
36 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
37 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11
38 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77
39 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63
40 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37
41 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57
42 INT6108 Gene_expression of Npy 292 0.78 110.65 148.21
43 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2
44 INT2780 Regulation of Gene_expression of Penk 265 0.62 32.45 143.88
45 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47
46 INT2541 Binding of Calca 200 0.48 67.14 134.62
47 INT5595 Positive_regulation of Pdyn 223 0.70 48.37 130.14
48 INT695 Binding of POMC 304 0.48 56.66 126.85
49 INT6822 Gene_expression of Pdyn 215 0.78 35.99 125.76
50 INT5008 Localization of Calca 204 0.81 80.35 125.16
51 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46
52 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64
53 INT2555 Positive_regulation of Localization of Penk 116 0.70 24.35 119.73
54 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75
55 INT1438 Localization of Pomc 360 0.81 101.26 116.47
56 INT5283 Positive_regulation of Npy 191 0.70 66.77 109.2
57 INT4936 Localization of Tacr1 125 0.80 35.7 107.7
58 INT12569 Localization of Oprd1 94 0.81 23.81 104.56
59 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66
60 INT293 Protein_catabolism of Penk 161 1.00 11.71 98.45
61 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61
62 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84
63 INT5594 Regulation of Pdyn 137 0.62 27.04 86.63
64 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03
65 INT4857 Regulation of Tacr1 115 0.62 39.01 84.52
66 INT8650 Gene_expression of Gal 152 0.78 61.97 81.72
67 INT6107 Localization of Npy 180 0.81 26.76 81.67
68 INT2289 Gene_expression of PENK 203 0.78 55.62 79.49
69 INT5593 Positive_regulation of Gene_expression of Pdyn 114 0.70 29.1 74.46
70 INT7028 Localization of Pdyn 90 0.81 8.89 73.54
71 INT442 Localization of PDYN 99 0.81 11.87 72.75
72 INT5852 Gene_expression of Penk 167 0.78 44.44 71.13
73 INT8346 Gene_expression of Qrfp 136 0.70 19.49 70.21
74 INT66416 Regulation of Pnoc 66 0.61 17.32 68.91
75 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26
76 INT462 Regulation of Pomc 157 0.62 41.67 67.27
77 INT6824 Regulation of Gene_expression of Pdyn 114 0.62 9.48 66.73
78 INT66531 Gene_expression of Pnoc 88 0.78 22.9 65.11
79 INT5573 Negative_regulation of Gene_expression of Penk 113 0.59 21.83 64.66
80 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
81 INT6761 Binding of CALCA 100 0.48 26.71 62.05
82 INT12175 Positive_regulation of PDYN 86 0.69 18.27 62.04
83 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97
84 INT66779 Binding of Pnoc 79 0.48 6.43 60.46
85 INT1430 Regulation of PDYN 88 0.60 16.99 60.32
86 INT4760 Negative_regulation of Gene_expression of Calca 93 0.59 34.19 60.3
87 INT65078 Negative_regulation of Pnoc 64 0.59 15.48 59.81
88 INT7032 Positive_regulation of Pdyn 94 0.66 26.51 58.83
89 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
90 INT7491 Localization of Pdyn 80 0.81 3.94 58.77
91 INT1307 Positive_regulation of Localization of Pomc 120 0.70 24.58 58.48
92 INT5819 Regulation of Localization of Penk 64 0.62 6.69 57.68
93 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
94 INT5017 Negative_regulation of Tacr1 76 0.58 17 57.07
95 INT1510 Binding of PDYN 94 0.48 4.68 56.44
96 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34
97 INT1463 Binding of Pomc 129 0.48 15.89 56.27
98 INT5598 Negative_regulation of Pdyn 95 0.59 14.4 55.43
99 INT2421 Positive_regulation of Positive_regulation of Penk 97 0.69 13.38 55.32
100 INT4241 Regulation of CALCA 87 0.62 28.19 55.29
101 INT6826 Transcription of Pdyn 130 0.71 22.19 54.88
102 INT5506 Positive_regulation of Gene_expression of Pomc 132 0.70 26.78 54.3
103 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54
104 INT6073 Negative_regulation of Localization of Penk 63 0.59 8.67 53.95
105 INT4891 Transcription of Calca 81 0.72 35.27 53.75
106 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66
107 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12
108 INT97674 Positive_regulation of Localization of Calca 70 0.69 27.71 51.79
109 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34
110 INT5338 Regulation of Npy 92 0.62 25.54 51.24
111 INT5136 Negative_regulation of PDYN 71 0.59 11.22 51.14
112 INT8690 Localization of Tac1 71 0.80 22.98 50.75
113 INT4985 Positive_regulation of Tac1 81 0.69 35.79 50.67
114 INT7287 Positive_regulation of Transcription of Penk 103 0.70 19.81 50.37
115 INT51163 Gene_expression of Gal 119 0.78 67.48 49.23
116 INT32718 Gene_expression of OPRD1 82 0.76 9.43 48.38
117 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02
118 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
119 INT5337 Negative_regulation of Npy 87 0.59 19.6 46.75
120 INT6823 Negative_regulation of Pdyn 68 0.58 13.95 46.12
121 INT8713 Regulation of Tac1 56 0.60 25.29 45.94
122 INT4776 Localization of TAC1 82 0.78 16.89 45.21
123 INT14853 Negative_regulation of Tac1 80 0.59 30.87 45.06
124 INT7828 Positive_regulation of Oprd1 55 0.69 14.11 42.86
125 INT1295 Binding of Pomc 85 0.48 12.92 42.8
126 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8
127 INT4850 Binding of Tac1 57 0.47 14.25 42.17
128 INT64440 Gene_expression of Pnoc 66 0.78 13.61 41.76
129 INT66532 Positive_regulation of Pnoc 46 0.70 14.99 41.39
130 INT28265 Positive_regulation of Calca 62 0.70 29.1 41.17
131 INT7029 Regulation of Pdyn 51 0.61 12.89 40.34
132 INT4862 Localization of PENK 62 0.81 11.57 40.28
133 INT2782 Regulation of Gene_expression of Pomc 75 0.62 15.04 38.97
134 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67
135 INT4925 Binding of Tacr1 57 0.48 17.39 38.38
136 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
137 INT5039 Positive_regulation of Gal 67 0.68 27.97 37.36
138 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58
139 INT4843 Gene_expression of Npff 50 0.78 12.92 36.37
140 INT8837 Positive_regulation of TAC1 59 0.67 21.94 35.97
141 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4
142 INT4892 Positive_regulation of Gene_expression of Tacr1 56 0.69 25.64 34.69
143 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29
144 INT1457 Negative_regulation of Binding of Penk 40 0.57 0.25 34.24
145 INT8784 Negative_regulation of Positive_regulation of Calca 40 0.59 14.67 33.49
146 INT7286 Regulation of Transcription of Penk 81 0.62 9.25 33.45
147 INT8746 Negative_regulation of Calca 50 0.59 21.22 33.45
148 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95
149 INT4727 Regulation of TAC1 60 0.47 6.74 32.83
150 INT7692 Positive_regulation of PENK 71 0.70 20.34 32.54
151 INT1711 Negative_regulation of Positive_regulation of Penk 54 0.59 6.55 32.42
152 INT14497 Gene_expression of GRP 82 0.78 17.67 32.27
153 INT610 Regulation of PENK 47 0.62 14.17 31.55
154 INT22239 Negative_regulation of TAC1 52 0.57 12.96 31.41
155 INT12397 Gene_expression of Oprd1 53 0.78 9.1 31.31
156 INT6277 Positive_regulation of Gene_expression of Pomc 76 0.70 21.45 31.09
157 INT15347 Positive_regulation of Localization of Pomc 81 0.70 28.1 31.01
158 INT8531 Transcription of PDYN 56 0.72 19.51 30.99
159 INT5505 Regulation of Localization of Pomc 54 0.61 6.96 30.77
160 INT11279 Positive_regulation of Penk 65 0.70 18.72 30.29
161 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66
162 INT12319 Positive_regulation of Cort 52 0.61 22.55 29.35
163 INT15000 Transcription of Oprd1 32 0.72 5.7 29.22
164 INT4868 Gene_expression of GAL 75 0.78 22.23 29.02
165 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76
166 INT10684 Negative_regulation of Protein_catabolism of Penk 41 0.59 2.33 28.63
167 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58
168 INT4861 Localization of GRP 84 0.80 8.26 28.03
169 INT22499 Regulation of Calca 42 0.62 17.32 28.02
170 INT5097 Localization of Sstr1 30 0.64 0.38 27.92
171 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69
172 INT5771 Binding of Oprd1 37 0.48 2.6 27.54
173 INT7565 Transcription of Pomc 69 0.72 14.46 27.41
174 INT8881 Regulation of Gene_expression of Tacr1 38 0.61 17.49 27.19
175 INT72677 Regulation of Gene_expression of Oprm1 45 0.62 13.95 26.75
176 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48
177 INT6934 Binding of OPRD1 51 0.48 7.72 25.73
178 INT11773 Gene_expression of Tac1 56 0.77 10 25.72
179 INT8779 Binding of TAC1 50 0.47 11.19 25.57
180 INT17925 Transcription of Npy 53 0.72 15.75 25.56
181 INT5851 Positive_regulation of Gene_expression of Penk 52 0.70 14.57 25.05
182 INT30276 Positive_regulation of Gene_expression of Pdyn 39 0.67 11.28 24.89
183 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52
184 INT66417 Localization of Pnoc 34 0.80 1.61 24.48
185 INT5596 Negative_regulation of Gene_expression of Pdyn 41 0.59 5.34 24.36
186 INT18400 Localization of Glp1r 97 0.80 11.96 24.32
187 INT12424 Binding of Npy 48 0.48 8.23 24.26
188 INT8380 Positive_regulation of Gene_expression of Npy 49 0.70 19.62 24.13
189 INT5592 Regulation of Regulation of Penk 36 0.62 4.37 24.02
190 INT2290 Protein_catabolism of POMC 41 0.99 4.86 23.36
191 INT21344 Negative_regulation of Penk 34 0.57 8.83 23.32
192 INT9526 Negative_regulation of Localization of Pomc 41 0.58 6.93 23.3
193 INT30386 Negative_regulation of OPRD1 33 0.52 4.34 23.06
194 INT15458 Gene_expression of NPY 50 0.76 22.67 23.03
195 INT5511 Negative_regulation of Gene_expression of Pomc 47 0.59 12.08 23.02
196 INT57253 Negative_regulation of Binding of Oprm1 24 0.43 5.27 22.67
197 INT16764 Transcription of Qrfp 39 0.69 6.29 21.61
198 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51
199 INT8389 Localization of Qrfp 38 0.78 5.11 21.39
200 INT31393 Positive_regulation of Localization of Oprd1 10 0.66 7.32 21.23
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