GO:0007219

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Name Notch signaling pathway
Categary Process
Go Slim No
Go Link GO:0007219
Unique Molecular Interactions 643
Total Molecular Interactions 900
Total Single Events 7089
Pain Genes Associated 65

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Notch signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for Notch signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128777 Binding of Cntn1 and Nav1 1 0.48 0.51 2.28
2 INT249483 Binding of Ephb1 and Efnb2 1 0.02 2.35 1.66
3 INT151889 Binding of Adarb1 and DLL1 1 0.00 0 1.66
4 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
5 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
6 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
7 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
8 INT128776 Cntn1 Positive_regulation of Gene_expression of Pde6b 1 0.02 0.55 1.26
9 INT59707 PSENEN Regulation of Negative_regulation of YY1 1 0.12 0.07 1.21
10 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
11 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
12 INT249481 Positive_regulation of Binding of Ephb1 and Efnb2 1 0.03 1.36 1.12
13 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07
14 INT87222 Nrg1 Regulation of Oprd1 1 0.00 0 1.07
15 INT346835 Gene_expression of Efnb2 Positive_regulation of Phosphorylation of Grin2b 1 0.27 1.07 1.03
16 INT210783 Bmp2 Positive_regulation of Tnip1 1 0.40 0.53 0.94
17 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
18 INT103930 Cps1 Negative_regulation of Gene_expression of Il2ra 1 0.02 0.25 0.93
19 INT210799 Bmp2 Positive_regulation of B2m 1 0.35 0.52 0.92
20 INT159996 Prkcg Regulation of Gene_expression of App 1 0.42 0.32 0.92
21 INT159993 App Regulation of Gene_expression of Bace1 1 0.46 0.32 0.92
22 INT159994 App Regulation of Gene_expression of Prkcg 1 0.42 0.32 0.92
23 INT193291 Binding of CAP1 and Cfd 1 0.02 0.13 0.91
24 INT193277 Binding of Cfd and Brs3 1 0.01 0.13 0.91
25 INT52761 Dll1 Regulation of Sptan1 1 0.07 0 0.89
26 INT52762 Dll1 Regulation of Drd1a 1 0.10 0 0.89
27 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87
28 INT167431 Binding of APP and MYO1C 1 0.23 1.38 0.83
29 INT187290 Binding of HEY1 and Gtf3a 1 0.00 6.18 0.83
30 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
31 INT107917 RETNLB Positive_regulation of Gene_expression of App 1 0.01 1.2 0.79
32 INT151882 Binding of YY1 and DLL1 1 0.00 0 0.79
33 INT151883 Negative_regulation of Binding of YY1 and DLL1 1 0.00 0 0.79
34 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
35 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77
36 INT98770 Binding of Dll1 and Gt(pU21)50Imeg 1 0.05 0 0.74
37 INT75399 Regulation of Binding of Dll1 and Oprd1 1 0.08 0 0.74
38 INT98771 Binding of Dll1 and Oprm1 1 0.29 0 0.74
39 INT75398 Binding of Dll1 and Oprd1 1 0.11 0 0.74
40 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 0.04 0.82 0.7
41 INT104301 Adam17 Regulation of Negative_regulation of Sell 1 0.39 0.58 0.69
42 INT214595 Binding of FOXC1 and TIMP1 1 0.02 0.96 0.66
43 INT344387 Efnb2 Positive_regulation of Phosphorylation of Tyr 1 0.01 1.05 0.66
44 INT148381 UFM1 Positive_regulation of JAG1 1 0.00 1.13 0.63
45 INT148379 UFM1 Positive_regulation of DLL1 1 0.00 1.13 0.63
46 INT2700 Binding of App and Cpe 1 0.00 0 0.63
47 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
48 INT118083 Aip Negative_regulation of Phosphorylation of APP 1 0.00 0.75 0.62
49 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
50 INT84771 Positive_regulation of Binding of App and Pag1 1 0.17 0.9 0.62
51 INT120203 Binding of App and Il1 1 0.17 1.28 0.59
52 INT120204 Binding of App and Il1f5 1 0.09 1.28 0.59
53 INT86644 Binding of OPRD1 and DLL1 1 0.28 0.17 0.58
54 INT84770 Binding of App and Pag1 1 0.13 0.89 0.57
55 INT167618 Rho Regulation of App 1 0.17 0.88 0.55
56 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55
57 INT249497 Efnb2 Positive_regulation of Phosphorylation of Grin2b 1 0.02 0.51 0.54
58 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
59 INT249499 Ephb1 Positive_regulation of Efnb2 1 0.04 0.95 0.54
60 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54
61 INT249536 Binding of EPHA1 and Efnb2 1 0.02 0.28 0.52
62 INT329587 Binding of PTX3 and HEY1 1 0.00 2.03 0.5
63 INT120834 Binding of CNTN1 and SCN3A 1 0.01 0.41 0.49
64 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
65 INT103936 Cps1 Negative_regulation of Il2ra 1 0.02 0.07 0.46
66 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
67 INT210793 Bmp2 Positive_regulation of Tsc22d3 1 0.32 0.26 0.46
68 INT167621 Psenen Positive_regulation of App 1 0.02 0.86 0.44
69 INT148377 PDP1 Positive_regulation of NOTCH1 1 0.44 0.64 0.44
70 INT148378 CP Positive_regulation of NOTCH1 1 0.11 0.64 0.44
71 INT167617 Bace2 Positive_regulation of App 1 0.06 0.87 0.44
72 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 0.00 0.88 0.44
73 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42
74 INT247599 Tlr4 Positive_regulation of Gene_expression of App 1 0.17 0.39 0.42
75 INT237896 Epn1 Regulation of Nps 1 0.06 0.19 0.41
76 INT139873 Negative_regulation of CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
77 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
78 INT99122 Binding of Cacna2d3 and DLL1 1 0.02 0 0.41
79 INT139874 CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
80 INT79577 APP Negative_regulation of PENK 1 0.12 0.35 0.4
81 INT78121 Positive_regulation of Binding of App and 20S 1 0.23 0.61 0.4
82 INT78122 Binding of App and 20S 1 0.16 0.61 0.4
83 INT323967 Il6 Positive_regulation of Gene_expression of App 1 0.10 0.86 0.38
84 INT56868 Binding of Rbm39 and Nle1 1 0.00 0 0.37
85 INT56869 Binding of Cck and Nle1 1 0.10 0 0.37
86 INT78854 APP Positive_regulation of Localization of IL6 1 0.14 0.79 0.37
87 INT237633 Cntn1 Regulation of Gene_expression of Ank3 1 0.00 0.23 0.33
88 INT237637 Cntn1 Positive_regulation of Gene_expression of Ank3 1 0.00 0.23 0.33
89 INT124376 Prodh2 Positive_regulation of App 1 0.00 0.66 0.33
90 INT124379 Prodh2 Positive_regulation of Localization of App 1 0.00 0.66 0.33
91 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32
92 INT128756 Binding of Esr1 and Foxc1 1 0.01 0.43 0.32
93 INT147434 Psenen Positive_regulation of APP 1 0.01 0.58 0.32
94 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31
95 INT68977 App Positive_regulation of Localization of Mmp9 1 0.05 0.38 0.3
96 INT166165 Binding of TGFB3 and Bmp2 1 0.00 0 0.3
97 INT135095 Negative_regulation of CTSB Negative_regulation of APP 1 0.00 0.74 0.3
98 INT237635 Cntn1 Regulation of Nfasc 1 0.04 0.22 0.3
99 INT333398 CFD Negative_regulation of Gene_expression of Pdgfa 1 0.02 0.64 0.3
100 INT237638 Cntn1 Positive_regulation of Nfasc 1 0.07 0.22 0.3
101 INT319220 FSIP1 Regulation of APP 1 0.29 1.46 0.29
102 INT180570 Binding of HEYL and Positive_regulation of DMD 1 0.00 1.08 0.28
103 INT214615 FOXC1 Positive_regulation of Gene_expression of Ang 1 0.01 0.29 0.28
104 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28
105 INT180564 HEYL Regulation of Regulation of DMD 1 0.00 0.88 0.28
106 INT214594 Binding of FOXC1 and IBD9 1 0.00 1.81 0.28
107 INT298280 Pou4f1 Negative_regulation of Gene_expression of Neurod4 1 0.38 0.48 0.27
108 INT79592 Binding of APP and Reg1 1 0.01 0.16 0.27
109 INT25946 Regulation of Binding of Penk and App 1 0.18 0.19 0.27
110 INT25944 Binding of Penk and App 1 0.15 0.19 0.27
111 INT356094 Binding of App and Tg 1 0.08 0.12 0.26
112 INT141634 Binding of Alb and Nrg1 1 0.00 0.3 0.26
113 INT139980 Negative_regulation of CTSB Negative_regulation of Gene_expression of APP 1 0.15 0.7 0.26
114 INT139981 CTSB Negative_regulation of Gene_expression of APP 1 0.11 0.7 0.26
115 INT39010 App Negative_regulation of Gene_expression of Gnrh1 1 0.05 0.07 0.26
116 INT235013 Binding of DSG1 and Adam17 1 0.07 1.34 0.26
117 INT234980 Positive_regulation of Egfr Positive_regulation of Adam17 1 0.09 1.33 0.26
118 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
119 INT114244 Cpox Negative_regulation of Gene_expression of APP 1 0.00 0.7 0.25
120 INT134522 Nrg1 Regulation of Gene_expression of Mpz 1 0.60 0.29 0.25
121 INT281798 CFD Regulation of Positive_regulation of Chrna4 1 0.01 0.24 0.24
122 INT191619 Binding of App and Flna 1 0.04 0.18 0.24
123 INT134523 Nrg1 Positive_regulation of Gene_expression of Mpz 1 0.49 0.32 0.23
124 INT333394 CFD Negative_regulation of Gene_expression of Cat 1 0.03 0.79 0.22
125 INT338421 Il2ra Negative_regulation of Gene_expression of Ik 1 0.00 1.27 0.22
126 INT70082 Binding of APP and TGM1 1 0.00 1.22 0.22
127 INT333397 CFD Negative_regulation of Gene_expression of Nos2 1 0.04 0.8 0.22
128 INT163863 Binding of MIB1 and Vim 1 0.02 1.06 0.21
129 INT52459 Binding of SUCLA2 and HEY2 1 0.01 0.09 0.21
130 INT319971 App Regulation of Enpp1 1 0.02 0.72 0.21
131 INT163864 Binding of MIB1 and Ema 1 0.04 1.07 0.21
132 INT237643 Binding of Cntn1 and Nfasc 1 0.06 0.05 0.21
133 INT45934 PKN1 Regulation of NOTCH2NL 1 0.01 0 0.2
134 INT297545 Pou3f3 Regulation of Hes1 1 0.05 0.41 0.2
135 INT297544 Pou3f3 Regulation of Notch1 1 0.06 0.41 0.2
136 INT203531 Pou4f1 Negative_regulation of Neurod4 1 0.46 0.54 0.2
137 INT316064 Binding of RBPJ and Csl 1 0.16 0.33 0.2
138 INT326575 Nrg1 Positive_regulation of Gene_expression of JUN 1 0.38 0.86 0.2
139 INT146687 Regulation of Binding of App and Aph1a 1 0.16 0.58 0.19
140 INT214591 FOXC1 Regulation of ICAM1 1 0.05 0.29 0.19
141 INT146686 Binding of App and Aph1a 1 0.14 0.58 0.19
142 INT25945 Plat Regulation of App 1 0.15 0.25 0.17
143 INT25947 Plat Regulation of Transcription of App 1 0.15 0.25 0.17
144 INT119265 Binding of CREBBP and PPM1E 1 0.01 0.46 0.17
145 INT333393 CFD Positive_regulation of Gene_expression of Timp1 1 0.07 0.82 0.16
146 INT180562 Binding of CYP27A1 and HEYL 1 0.02 0.29 0.16
147 INT319974 App Negative_regulation of Enpp1 1 0.02 0.58 0.16
148 INT204478 Fmr1 Regulation of Gene_expression of App 1 0.50 1.44 0.16
149 INT316052 Notch1 Regulation of Binding of Cd8a 1 0.01 0.86 0.15
150 INT316053 Notch1 Regulation of Binding of Cd4 1 0.02 0.86 0.15
151 INT201744 Ngf Regulation of Transcription of App 1 0.06 0.39 0.15
152 INT316050 Binding of Notch1 and Regulation of Binding of Cd8a 1 0.01 0.86 0.15
153 INT201728 Ntrk1 Regulation of Transcription of App 1 0.03 0.39 0.15
154 INT43494 Akt1s1 Regulation of Gene_expression of Ifng 1 0.05 0 0.15
155 INT316051 Binding of Notch1 and Regulation of Binding of Cd4 1 0.02 0.86 0.15
156 INT319972 App Negative_regulation of Gene_expression of Enpp1 1 0.02 1.87 0.15
157 INT136606 Binding of RAN and DLL1 1 0.33 0.45 0.15
158 INT286476 Binding of App and Itm2b 1 0.47 5.24 0.14
159 INT231274 Nrg1 Regulation of Gene_expression of Akt1 1 0.19 0 0.14
160 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
161 INT161086 NOTCH3 Regulation of Notch3 1 0.51 1.06 0.14
162 INT139849 Binding of App and Bace1 7 0.41 0.85 0.13
163 INT204489 Fmr1 Regulation of App 1 0.50 1.71 0.13
164 INT214593 Binding of FOXC1 and OAP 1 0.01 0.25 0.13
165 INT333396 CFD Positive_regulation of Bcl2l1 1 0.05 0.98 0.13
166 INT287878 Binding of CREB1 and CREBBP 2 0.01 0.16 0.12
167 INT220622 App Positive_regulation of Rip 2 0.14 0.24 0.12
168 INT180567 HEYL Regulation of Positive_regulation of IBSP 1 0.01 0.18 0.12
169 INT254488 Dtx1 Regulation of Sorbs1 1 0.01 0 0.12
170 INT283719 Id2 Regulation of Regulation of Hes7 1 0.00 0.31 0.12
171 INT254490 Dtx1 Regulation of Gopc 1 0.04 0 0.12
172 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
173 INT308660 Binding of Ager and App 1 0.08 1.22 0.12
174 INT211996 Erbb3 Positive_regulation of Nrg1 2 0.03 0.67 0.11
175 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
176 INT249495 Binding of Grin2b and Efnb2 1 0.02 0.05 0.11
177 INT70084 Negative_regulation of Binding of APP and TGM1 1 0.00 0.61 0.11
178 INT259629 Binding of Adam17 and Timp3 1 0.01 0.19 0.11
179 INT70083 TGM1 Positive_regulation of Binding of APP 1 0.00 0.61 0.11
180 INT283710 Binding of Id2 and Hes7 1 0.01 0.13 0.11
181 INT123101 Binding of APP and Ache 1 0.07 0.32 0.11
182 INT204477 Binding of App and Scn10a 1 0.17 0.36 0.1
183 INT139847 Binding of App and Bace2 1 0.03 0.16 0.1
184 INT297546 Neurod1 Regulation of Notch1 1 0.05 0.2 0.1
185 INT297548 Neurod1 Regulation of Hes1 1 0.05 0.2 0.1
186 INT139850 Binding of MBTPS1 and App 1 0.00 0.16 0.1
187 INT238038 Binding of BMP2 and OPLL 1 0.20 2.45 0.09
188 INT193963 App Regulation of Gene_expression of Ps 1 0.06 0.93 0.09
189 INT254492 Dtx1 Regulation of Cldn11 1 0.03 0 0.09
190 INT231273 Binding of Egfr and Nrg1 1 0.12 0 0.09
191 INT278217 Binding of Ciita and Notch1 1 0.41 0.22 0.09
192 INT356112 Binding of App and Apba1 1 0.24 0.29 0.09
193 INT262701 App Positive_regulation of Aplp2 1 0.12 0.25 0.09
194 INT341008 Nrg1 Regulation of Binding of Erbb4 1 0.04 0 0.09
195 INT262705 App Positive_regulation of Aplp1 1 0.13 0.25 0.09
196 INT124036 Binding of App and Dnahc8 1 0.03 0.14 0.09
197 INT54096 NRG1 Regulation of Protein_catabolism of Fgg 1 0.01 0 0.09
198 INT180561 HEYL Negative_regulation of IBSP 1 0.01 0.19 0.09
199 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
200 INT205135 Binding of APOE and APP 1 0.05 0.35 0.08

Single Events

The table below shows the top 100 pain related interactions that have been reported for Notch signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in Notch signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT65500 Gene_expression of App 605 0.78 429.94 98.31
2 INT29743 Negative_regulation of App 91 0.59 65.56 31.26
3 INT47712 Positive_regulation of App 135 0.69 101.38 28.94
4 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62
5 INT44954 Gene_expression of APP 191 0.78 105.86 23.9
6 INT11625 Localization of App 98 0.78 55.46 20.86
7 INT16794 Binding of App 103 0.48 64.87 19.79
8 INT65502 Regulation of App 77 0.62 52.05 19.44
9 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68
10 INT10187 Gene_expression of Il2ra 91 0.78 52.67 16.66
11 INT256282 Gene_expression of Efnb2 3 0.76 17.61 16.41
12 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
13 INT54052 Gene_expression of App 33 0.78 25.08 14.7
14 INT50056 Positive_regulation of Dll1 13 0.67 3.16 13.7
15 INT29745 Binding of APP 47 0.48 26.49 12.4
16 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38
17 INT56883 Positive_regulation of Dll1 8 0.49 3.49 12.25
18 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48
19 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15
20 INT41569 Regulation of APP 32 0.62 17.15 9.4
21 INT56884 Gene_expression of Dll1 9 0.48 1.15 8.98
22 INT56019 Gene_expression of Dll1 11 0.78 3.38 8.71
23 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
24 INT55859 Binding of Dll1 6 0.35 0 7.64
25 INT56031 Positive_regulation of App 25 0.69 13.46 7.37
26 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2
27 INT58607 Negative_regulation of Dll1 9 0.43 1.89 7.06
28 INT70287 Positive_regulation of Gene_expression of Dll1 6 0.70 3.58 6.55
29 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41
30 INT148384 Positive_regulation of HEY1 19 0.43 29.76 5.89
31 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
32 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
33 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65
34 INT107173 Phosphorylation of App 20 0.82 12.64 5.3
35 INT99823 Positive_regulation of Gene_expression of APP 31 0.70 21.52 5.09
36 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06
37 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82
38 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74
39 INT187286 Binding of HEY1 17 0.32 31.21 4.52
40 INT78116 Positive_regulation of Gene_expression of App 12 0.70 10.78 4.52
41 INT71406 Regulation of Dll1 3 0.35 0.79 4.44
42 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41
43 INT104299 Negative_regulation of Adam17 18 0.47 12.03 4.39
44 INT176618 Gene_expression of HEY1 29 0.59 36 4.37
45 INT111068 Regulation of Psenen 6 0.35 4.17 4.33
46 INT10542 Gene_expression of DLL1 16 0.71 3.7 4.21
47 INT58003 Localization of APP 32 0.80 13.75 4.2
48 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
49 INT15771 Gene_expression of Nrg1 34 0.67 3.16 4.11
50 INT40036 Binding of DLL1 10 0.36 2.88 3.95
51 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94
52 INT72179 Negative_regulation of Dll1 5 0.33 4.09 3.84
53 INT346828 Regulation of Efnb2 1 0.61 8.57 3.81
54 INT346826 Positive_regulation of Gene_expression of Efnb2 1 0.46 3.88 3.71
55 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7
56 INT11627 Positive_regulation of Localization of App 14 0.62 6.27 3.64
57 INT99819 Negative_regulation of Positive_regulation of APP 6 0.58 4.41 3.64
58 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54
59 INT62678 Negative_regulation of JAG1 8 0.41 6.95 3.5
60 INT70089 Negative_regulation of Binding of APP 7 0.59 6.45 3.44
61 INT10188 Positive_regulation of Il2ra 19 0.45 11.6 3.37
62 INT134786 Gene_expression of Adam10 17 0.68 7.61 3.29
63 INT146890 Gene_expression of Cfd 15 0.66 4.42 3.28
64 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
65 INT61087 Positive_regulation of Gene_expression of Il2ra 12 0.35 9.1 3.25
66 INT49190 Regulation of Dll1 3 0.44 0.26 3.24
67 INT137532 Negative_regulation of HEY2 1 0.31 1.69 3.18
68 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05
69 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
70 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01
71 INT55148 Binding of Dll1 5 0.48 0.66 2.97
72 INT108773 Negative_regulation of Binding of App 10 0.42 7.26 2.96
73 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
74 INT346829 Negative_regulation of Efnb2 1 0.42 5.08 2.94
75 INT54055 Regulation of Gene_expression of App 7 0.62 4.04 2.93
76 INT145187 Gene_expression of Efnb2 4 0.22 3.43 2.92
77 INT10189 Negative_regulation of Gene_expression of Il2ra 8 0.32 8.05 2.91
78 INT102157 Gene_expression of Adam17 3 0.58 4.17 2.86
79 INT139872 Regulation of Notch1 14 0.45 7.69 2.82
80 INT178772 Transcription of App 17 0.70 10.79 2.79
81 INT147429 Negative_regulation of Positive_regulation of App 8 0.40 8.73 2.78
82 INT54054 Binding of App 4 0.48 10.89 2.78
83 INT66891 Negative_regulation of Positive_regulation of Dll1 1 0.41 0 2.72
84 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64
85 INT43483 Gene_expression of DLL4 7 0.60 0.89 2.59
86 INT67329 Positive_regulation of Positive_regulation of Dll1 2 0.32 0 2.56
87 INT193319 Positive_regulation of Efnb2 2 0.49 2.1 2.47
88 INT346831 Regulation of Gene_expression of Efnb2 1 0.44 2.83 2.47
89 INT132315 Positive_regulation of DLL1 6 0.67 3.4 2.45
90 INT163544 Binding of Psen1 40 0.36 15.28 2.42
91 INT237875 Gene_expression of Epn1 1 0.10 1.26 2.4
92 INT83325 Regulation of Gene_expression of Il2ra 8 0.48 3.59 2.36
93 INT162513 Regulation of Protein_catabolism of APP 5 0.51 1.79 2.36
94 INT11626 Regulation of Localization of App 4 0.45 1.51 2.34
95 INT56030 Regulation of App 8 0.62 4.06 2.32
96 INT346834 Phosphorylation of Efnb2 1 0.62 1.54 2.19
97 INT50057 Regulation of Notch1 3 0.39 0.87 2.14
98 INT124772 Regulation of Binding of App 6 0.45 4.92 2.09
99 INT39008 Localization of App 13 0.77 9.07 2.05
100 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
101 INT168983 Negative_regulation of Nrg1 11 0.43 3.4 2.03
102 INT60723 Localization of Psen2 5 0.68 2.11 2.02
103 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
104 INT142774 Regulation of Phosphorylation of App 1 0.59 2.27 1.93
105 INT237873 Regulation of Epn1 1 0.07 2.12 1.91
106 INT303352 Gene_expression of Jag1 19 0.73 7.68 1.89
107 INT121337 Negative_regulation of HEY1 7 0.20 12.91 1.89
108 INT140036 Positive_regulation of Gene_expression of Notch1 6 0.61 2 1.86
109 INT117346 Positive_regulation of ADAM17 5 0.50 6.69 1.86
110 INT47914 Regulation of Il2ra 5 0.18 3.05 1.86
111 INT52633 Negative_regulation of Notch1 4 0.42 2.99 1.84
112 INT121117 Regulation of Protein_catabolism of App 10 0.62 6.41 1.78
113 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
114 INT107915 Regulation of Negative_regulation of App 6 0.45 4.47 1.76
115 INT130874 Negative_regulation of Gene_expression of ADAM17 3 0.43 5.03 1.76
116 INT159099 Negative_regulation of Positive_regulation of Dll1 1 0.25 0.74 1.76
117 INT159100 Regulation of Positive_regulation of Dll1 1 0.26 0.7 1.73
118 INT145184 Positive_regulation of Gene_expression of Efnb2 3 0.20 1.94 1.69
119 INT99258 Regulation of Aph1a 3 0.25 2.79 1.68
120 INT159098 Negative_regulation of Gene_expression of Dll1 1 0.18 0.62 1.65
121 INT46766 Negative_regulation of Il2ra 9 0.57 5.27 1.64
122 INT52757 Localization of Dll1 1 0.20 0 1.6
123 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57
124 INT130332 Gene_expression of Adam17 14 0.50 4.84 1.56
125 INT244735 Gene_expression of Ascl1 12 0.58 2.48 1.54
126 INT117033 Gene_expression of JAG1 13 0.65 11.46 1.52
127 INT133863 Positive_regulation of Protein_catabolism of App 12 0.59 7.53 1.52
128 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
129 INT105784 Binding of Nrg1 7 0.37 1.29 1.52
130 INT163381 Transcription of Notch1 2 0.69 0.41 1.52
131 INT58004 Positive_regulation of Localization of APP 5 0.46 2.1 1.5
132 INT54996 Regulation of KAT2B 1 0.19 0.38 1.45
133 INT25943 Transcription of App 5 0.53 1.79 1.44
134 INT105296 Regulation of DLL1 3 0.11 0.77 1.43
135 INT130014 Positive_regulation of BMP2 11 0.66 5.34 1.42
136 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
137 INT125796 Regulation of Gene_expression of APP 8 0.59 5.95 1.41
138 INT170853 Positive_regulation of Gene_expression of CFD 7 0.23 9.89 1.41
139 INT129700 Regulation of Positive_regulation of App 3 0.43 1.86 1.41
140 INT120836 Positive_regulation of CNTN1 1 0.48 1.42 1.4
141 INT125980 Binding of CFD 8 0.42 10.96 1.39
142 INT160950 Gene_expression of Cntn1 5 0.53 1.7 1.38
143 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
144 INT141529 Regulation of Positive_regulation of APP 3 0.44 0.31 1.34
145 INT130098 Negative_regulation of NOTCH1 11 0.42 5.45 1.33
146 INT78861 Negative_regulation of Transcription of Adam17 2 0.29 1.4 1.32
147 INT110784 Protein_catabolism of Notch1 8 0.21 2.32 1.31
148 INT145183 Negative_regulation of Gene_expression of Efnb2 2 0.17 1.51 1.31
149 INT78859 Transcription of Adam17 2 0.47 1.39 1.31
150 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29
151 INT158056 Localization of Nrg1 13 0.79 3.11 1.28
152 INT103488 Positive_regulation of Localization of App 5 0.50 3.05 1.28
153 INT149295 Regulation of NOTCH1 10 0.13 4.26 1.22
154 INT234893 Positive_regulation of Adam17 4 0.38 3.78 1.22
155 INT303362 Regulation of Jag1 2 0.22 2.91 1.22
156 INT133371 Negative_regulation of Binding of Dll1 1 0.41 0.5 1.22
157 INT59711 Negative_regulation of Positive_regulation of PSENEN 1 0.17 0.07 1.21
158 INT39711 Negative_regulation of FOXC1 4 0.41 4.29 1.2
159 INT180588 Gene_expression of HEYL 13 0.52 8.37 1.19
160 INT59712 Positive_regulation of PSENEN 3 0.21 0.23 1.19
161 INT110780 Localization of Notch1 2 0.06 0.47 1.19
162 INT81311 Gene_expression of FOXC1 9 0.44 3.46 1.18
163 INT100137 Positive_regulation of Negative_regulation of App 2 0.41 1.26 1.16
164 INT39818 Positive_regulation of Cfd 8 0.45 3.36 1.15
165 INT180580 Binding of HEYL 7 0.17 4.49 1.15
166 INT35095 Negative_regulation of Notch2 3 0.36 0.06 1.15
167 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14
168 INT135899 Regulation of Binding of APP 3 0.45 1.22 1.14
169 INT30851 Gene_expression of NRG1 8 0.67 4.64 1.12
170 INT123727 Negative_regulation of Notch1 6 0.21 1.22 1.11
171 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11
172 INT59889 Regulation of Cfd 3 0.39 0.21 1.1
173 INT146891 Positive_regulation of Gene_expression of Cfd 2 0.39 0.75 1.1
174 INT203483 Binding of Neurod4 1 0.36 1.96 1.09
175 INT346832 Negative_regulation of Gene_expression of Efnb2 1 0.42 0.75 1.09
176 INT209099 Binding of Cfd 14 0.15 3.75 1.08
177 INT39009 Negative_regulation of App 6 0.38 3.37 1.07
178 INT160538 Binding of Bmp2 4 0.40 2.08 1.07
179 INT156427 Localization of FOXC1 2 0.73 1.36 1.07
180 INT120843 Gene_expression of CNTN1 7 0.54 4.27 1.06
181 INT101994 Positive_regulation of Nrg1 10 0.50 1.24 1.05
182 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03
183 INT49505 Binding of NOTCH3 6 0.47 6.4 1.03
184 INT187289 Regulation of HEY1 5 0.39 7.8 1.03
185 INT132435 Negative_regulation of ADAM17 2 0.50 3.75 1.02
186 INT99121 Transcription of DLL1 1 0.14 0 1.02
187 INT98171 Binding of DLL4 2 0.23 0.1 1.01
188 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
189 INT214609 Positive_regulation of Gene_expression of FOXC1 1 0.08 1.78 1
190 INT104284 Positive_regulation of Notch3 7 0.50 5.57 0.99
191 INT46334 Binding of FOXC1 2 0.36 2.66 0.99
192 INT43131 Regulation of FOXC1 3 0.36 1.09 0.98
193 INT19084 Negative_regulation of NRG1 5 0.42 4.9 0.96
194 INT203445 Gene_expression of Hes7 3 0.03 2.93 0.96
195 INT6833 Binding of Notch1 4 0.36 0.05 0.94
196 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
197 INT114664 Binding of BMP2 12 0.37 6.54 0.91
198 INT346827 Binding of Efnb2 1 0.37 1.56 0.91
199 INT187288 Positive_regulation of Gene_expression of HEY1 5 0.17 8.42 0.89
200 INT168888 Transcription of Neurod4 2 0.66 0.62 0.89
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