GO:0007220

From wiki-pain
Jump to: navigation, search
Name Notch receptor processing
Categary Process
Go Slim No
Go Link GO:0007220
Unique Molecular Interactions 99
Total Molecular Interactions 132
Total Single Events 1460
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Notch receptor processing. They are ordered first by their pain relevance and then by number of times they were reported for Notch receptor processing. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT151889 Binding of Adarb1 and DLL1 1 0.00 0 1.66
2 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
3 INT59707 PSENEN Regulation of Negative_regulation of YY1 1 0.12 0.07 1.21
4 INT151882 Binding of YY1 and DLL1 1 0.00 0 0.79
5 INT151883 Negative_regulation of Binding of YY1 and DLL1 1 0.00 0 0.79
6 INT148381 UFM1 Positive_regulation of JAG1 1 0.00 1.13 0.63
7 INT148379 UFM1 Positive_regulation of DLL1 1 0.00 1.13 0.63
8 INT86644 Binding of OPRD1 and DLL1 1 0.28 0.17 0.58
9 INT148377 PDP1 Positive_regulation of NOTCH1 1 0.44 0.64 0.44
10 INT148378 CP Positive_regulation of NOTCH1 1 0.11 0.64 0.44
11 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
12 INT99122 Binding of Cacna2d3 and DLL1 1 0.02 0 0.41
13 INT297547 Pou3f3 Regulation of Psen1 1 0.00 0.41 0.25
14 INT146687 Regulation of Binding of App and Aph1a 1 0.16 0.58 0.19
15 INT146686 Binding of App and Aph1a 1 0.14 0.58 0.19
16 INT136606 Binding of RAN and DLL1 1 0.33 0.45 0.15
17 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
18 INT161086 NOTCH3 Regulation of Notch3 1 0.51 1.06 0.14
19 INT297543 Neurod1 Regulation of Psen1 1 0.00 0.2 0.12
20 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
21 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
22 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
23 INT273288 Psen1 Regulation of Prdx2 1 0.01 0.7 0.06
24 INT189557 Binding of NOTCH1 and ROBO4 1 0.01 0.22 0.06
25 INT345245 Adam9 Regulation of Adam10 1 0.09 0.18 0.05
26 INT328293 Binding of JAG2 and GHS 1 0.03 0.09 0.05
27 INT193967 Binding of PSEN1 and Psen1 1 0.41 1.2 0.05
28 INT193970 Binding of PSEN1 and Psen2 1 0.36 2.06 0.05
29 INT328365 Binding of JAG2 and Ghrl 1 0.03 0.07 0.05
30 INT332483 Binding of JAG1 and SGPP2 1 0.21 0.23 0.04
31 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
32 INT331477 PSEN2 Regulation of Gene_expression of Psen1 1 0.00 0.15 0.03
33 INT354896 Binding of Psen2 and Fancd2 1 0.04 0.75 0.03
34 INT347165 Binding of NOTCH1 and PAX5 1 0.05 0.86 0.03
35 INT331478 Psen1 Regulation of Gene_expression of PSEN2 1 0.00 0.15 0.03
36 INT347163 NOTCH1 Positive_regulation of MSC 1 0.03 0.85 0.03
37 INT347164 NOTCH1 Negative_regulation of Gene_expression of EBF1 1 0.03 0.85 0.03
38 INT258529 Binding of JAG1 and NOTCH1 3 0.06 2.44 0
39 INT258528 Binding of NOTCH1 and DLL1 2 0.07 1.6 0
40 INT291330 Binding of ENO1 and NOTCH1 1 0.03 1.33 0
41 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
42 INT193962 Binding of Psen1 and Ncstn 1 0.13 0.08 0
43 INT230144 OSBP Regulation of Gene_expression of NOTCH2 1 0.30 0 0
44 INT334644 Binding of PSEN1 and TTN 1 0.01 0 0
45 INT217402 Binding of Bace1 and PSENEN 1 0.02 0.72 0
46 INT350098 Gene_expression of PSEN2 Positive_regulation of Gene_expression of Hmox1 1 0.39 0 0
47 INT273289 Binding of Psen2 and Ryr2 1 0.27 4.53 0
48 INT291329 Binding of NOTCH1 and CERS1 1 0.06 1.42 0
49 INT227218 Binding of JAG1 and CD8A 1 0.05 0.5 0
50 INT217398 Binding of Psen2 and Bace1 1 0.12 1.44 0
51 INT320824 VEGFA Positive_regulation of DLL4 1 0.40 0.41 0
52 INT193955 Binding of Psen1 and Psen2 1 0.37 1.64 0
53 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
54 INT286331 Binding of Psen1 and Ror1 1 0.27 0 0
55 INT193968 Binding of PSEN1 and Ps 1 0.07 0.66 0
56 INT262712 Psen1 Regulation of Gene_expression of Bace1 1 0.22 0.07 0
57 INT217400 Binding of Psen1 and Bace1 1 0.17 1.43 0
58 INT286337 PSENEN Regulation of Psen1 1 0.07 0.37 0
59 INT320825 VEGFA Positive_regulation of Gene_expression of DLL4 1 0.40 0.41 0
60 INT193958 Binding of Pld1 and Psen1 1 0.17 0 0
61 INT193953 Binding of Bcl2l1 and Psen1 1 0.07 0.66 0
62 INT285770 Binding of NOTCH1 and Das 1 0.00 1.14 0
63 INT193956 Binding of Psen1 and Rab6a 1 0.15 0 0
64 INT294428 PSEN2 Regulation of Gene_expression of Tp53 1 0.49 0.86 0
65 INT294429 PSEN2 Negative_regulation of Tp53 1 0.46 1.03 0
66 INT193957 Binding of Bcl2l1 and Psen2 1 0.07 0.66 0
67 INT285769 Das Regulation of NOTCH1 1 0.00 0.78 0
68 INT331479 Binding of PSEN2 and Psen1 1 0.00 0.07 0
69 INT291333 Binding of CSHL1 and NOTCH1 1 0.05 1.16 0
70 INT234221 Negative_regulation of PSEN1 Negative_regulation of Gene_expression of APP 1 0.33 0.32 0
71 INT356107 Binding of Ncstn and Aph1a 1 0.05 0.06 0
72 INT258564 Binding of NOTCH1 and Crlf2 1 0.27 0.67 0
73 INT334645 Binding of PSEN1 and HM13 1 0.01 0 0
74 INT230149 Binding of APP and NOTCH2 1 0.32 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for Notch receptor processing. They are ordered first by their pain relevance and then by number of times they were reported in Notch receptor processing. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
2 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
3 INT111069 Regulation of Psen1 19 0.44 7.78 5.87
4 INT60724 Gene_expression of Psen2 30 0.72 27 5.79
5 INT10542 Gene_expression of DLL1 16 0.71 3.7 4.21
6 INT111067 Positive_regulation of Gene_expression of Psen1 32 0.68 21.2 4.19
7 INT40036 Binding of DLL1 10 0.36 2.88 3.95
8 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7
9 INT62678 Negative_regulation of JAG1 8 0.41 6.95 3.5
10 INT134786 Gene_expression of Adam10 17 0.68 7.61 3.29
11 INT211591 Negative_regulation of PSEN1 14 0.57 5.73 3.26
12 INT91761 Gene_expression of PSEN2 38 0.75 22.93 3.03
13 INT193936 Positive_regulation of PSEN1 5 0.58 11.57 2.95
14 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64
15 INT43483 Gene_expression of DLL4 7 0.60 0.89 2.59
16 INT132315 Positive_regulation of DLL1 6 0.67 3.4 2.45
17 INT163544 Binding of Psen1 40 0.36 15.28 2.42
18 INT181507 Positive_regulation of Psen1 22 0.49 7.59 2.04
19 INT60723 Localization of Psen2 5 0.68 2.11 2.02
20 INT193939 Binding of PSEN1 10 0.36 6.16 1.93
21 INT111070 Negative_regulation of Gene_expression of Psen1 17 0.42 9.47 1.77
22 INT99258 Regulation of Aph1a 3 0.25 2.79 1.68
23 INT117033 Gene_expression of JAG1 13 0.65 11.46 1.52
24 INT282434 Regulation of Gene_expression of Psen1 9 0.50 2.85 1.52
25 INT105296 Regulation of DLL1 3 0.11 0.77 1.43
26 INT78646 Regulation of Psen2 4 0.20 1.78 1.42
27 INT181509 Negative_regulation of Psen1 17 0.57 11.53 1.35
28 INT130098 Negative_regulation of NOTCH1 11 0.42 5.45 1.33
29 INT149295 Regulation of NOTCH1 10 0.13 4.26 1.22
30 INT59711 Negative_regulation of Positive_regulation of PSENEN 1 0.17 0.07 1.21
31 INT59712 Positive_regulation of PSENEN 3 0.21 0.23 1.19
32 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14
33 INT49505 Binding of NOTCH3 6 0.47 6.4 1.03
34 INT99121 Transcription of DLL1 1 0.14 0 1.02
35 INT98171 Binding of DLL4 2 0.23 0.1 1.01
36 INT78645 Negative_regulation of Gene_expression of Psen2 1 0.14 0.13 1.01
37 INT91771 Positive_regulation of Gene_expression of PSEN1 13 0.49 8.93 0.93
38 INT29981 Binding of PSENEN 2 0.17 0.24 0.86
39 INT180100 Positive_regulation of Adam10 6 0.33 2 0.84
40 INT78647 Positive_regulation of Localization of Psen2 1 0.16 0.14 0.83
41 INT115441 Positive_regulation of Aph1a 1 0.02 0.46 0.82
42 INT237406 Positive_regulation of Binding of Psen1 1 0.29 0 0.8
43 INT134789 Negative_regulation of Gene_expression of Adam10 1 0.30 1.22 0.78
44 INT94756 Positive_regulation of PSEN2 8 0.49 4.59 0.77
45 INT99120 Positive_regulation of Transcription of DLL1 1 0.10 0 0.77
46 INT286313 Transcription of Psen1 9 0.70 2.26 0.76
47 INT193849 Positive_regulation of Gene_expression of Psen2 5 0.44 4.92 0.76
48 INT8146 Gene_expression of PSENEN 2 0.14 0.89 0.75
49 INT78649 Binding of Psen2 7 0.36 5.9 0.73
50 INT78648 Regulation of Binding of Psen2 1 0.14 0.2 0.73
51 INT98172 Regulation of Binding of DLL4 1 0.14 0.1 0.71
52 INT91765 Positive_regulation of Gene_expression of PSEN2 8 0.49 4.57 0.63
53 INT74781 Regulation of JAG1 6 0.39 2.75 0.63
54 INT148382 Positive_regulation of JAG1 5 0.23 3.88 0.63
55 INT148387 Positive_regulation of NOTCH3 1 0.55 1.23 0.61
56 INT136920 Positive_regulation of Gene_expression of NOTCH1 12 0.49 8.25 0.59
57 INT151401 Localization of JAG1 4 0.65 1.88 0.58
58 INT327666 Regulation of Adam10 1 0.20 0 0.55
59 INT149294 Regulation of Localization of NOTCH1 1 0.10 0.9 0.55
60 INT217394 Regulation of Binding of PSEN1 1 0.44 1.58 0.53
61 INT149297 Protein_catabolism of NOTCH1 2 0.15 0.87 0.51
62 INT158426 Binding of NOTCH1 10 0.36 7.95 0.45
63 INT316041 Transcription of Psen2 1 0.64 1.1 0.45
64 INT121118 Regulation of Protein_catabolism of Aph1a 1 0.06 0.35 0.45
65 INT121119 Protein_catabolism of Aph1a 1 0.13 0.35 0.45
66 INT234249 Regulation of PSEN1 6 0.37 2.21 0.43
67 INT234257 Regulation of Gene_expression of PSEN1 6 0.44 1.98 0.42
68 INT193856 Localization of Psen1 19 0.73 9.79 0.41
69 INT151400 Binding of JAG1 14 0.37 7.96 0.39
70 INT36396 Positive_regulation of Psen2 6 0.44 4.57 0.39
71 INT177773 Localization of PSEN1 4 0.73 0.89 0.36
72 INT261682 Positive_regulation of Positive_regulation of PSEN2 1 0.21 0.55 0.33
73 INT246100 Positive_regulation of Gene_expression of Adam10 4 0.61 1.2 0.3
74 INT10543 Negative_regulation of DLL1 3 0.14 0.67 0.3
75 INT224298 Negative_regulation of PSEN2 6 0.57 2.29 0.28
76 INT316045 Negative_regulation of Negative_regulation of Psen1 1 0.42 1.58 0.27
77 INT261676 Negative_regulation of Positive_regulation of PSEN1 1 0.36 1.59 0.25
78 INT172525 Localization of PSEN2 5 0.73 4.17 0.24
79 INT130099 Negative_regulation of Positive_regulation of NOTCH1 4 0.43 2.56 0.21
80 INT181508 Regulation of Regulation of Psen1 2 0.33 0.51 0.2
81 INT130096 Positive_regulation of Positive_regulation of NOTCH1 2 0.50 1.15 0.18
82 INT286317 Positive_regulation of Transcription of Psen1 1 0.37 0.32 0.17
83 INT136921 Gene_expression of NOTCH3 5 0.67 4.27 0.16
84 INT64253 Localization of NOTCH3 1 0.78 0.97 0.16
85 INT64252 Negative_regulation of Localization of NOTCH3 1 0.41 0.97 0.16
86 INT237404 Regulation of Positive_regulation of Adam10 1 0.30 0.83 0.16
87 INT136609 Positive_regulation of Binding of DLL1 1 0.49 0.45 0.15
88 INT37256 Binding of NOTCH2 2 0.22 1.35 0.14
89 INT136922 Positive_regulation of Gene_expression of DLL1 2 0.46 1.28 0.13
90 INT336359 Positive_regulation of Phosphorylation of Psen1 1 0.33 0.4 0.13
91 INT336361 Phosphorylation of Psen1 1 0.54 0.34 0.13
92 INT136919 Negative_regulation of Gene_expression of DLL1 1 0.54 0.3 0.13
93 INT136931 Negative_regulation of NOTCH3 1 0.42 1.08 0.13
94 INT338718 Positive_regulation of Localization of NOTCH1 1 0.04 0.6 0.13
95 INT176595 Negative_regulation of Gene_expression of PSEN2 1 0.24 1.01 0.11
96 INT193841 Regulation of Gene_expression of Psen2 1 0.40 1.66 0.11
97 INT201694 Negative_regulation of Gene_expression of PSEN1 3 0.41 2.31 0.1
98 INT136924 Positive_regulation of JAG2 1 0.04 0.34 0.1
99 INT273285 Negative_regulation of Localization of Psen1 1 0.36 0.99 0.09
100 INT109131 Regulation of PSEN2 3 0.44 0.55 0.08
101 INT193862 Positive_regulation of Positive_regulation of Psen1 3 0.49 0.9 0.08
102 INT193872 Positive_regulation of Localization of Psen1 3 0.49 1.39 0.08
103 INT141999 Regulation of Gene_expression of NOTCH1 2 0.04 0.97 0.08
104 INT286316 Gene_expression of Aph1a 1 0.33 0.1 0.08
105 INT261678 Positive_regulation of Positive_regulation of PSEN1 1 0.42 0.62 0.08
106 INT193890 Regulation of Positive_regulation of Psen1 1 0.44 0.66 0.08
107 INT193938 Phosphorylation of PSEN1 5 0.79 1.6 0.07
108 INT356058 Negative_regulation of Adam10 1 0.23 0.8 0.07
109 INT300142 Positive_regulation of NOTCH2 1 0.16 1.26 0.07
110 INT176592 Transcription of PSEN2 5 0.33 0.41 0.05
111 INT193859 Negative_regulation of Binding of Psen1 3 0.42 1.85 0.05
112 INT136925 Gene_expression of NOTCH2 2 0.61 0.56 0.05
113 INT331406 Negative_regulation of Regulation of Psen1 1 0.04 0.09 0.05
114 INT328343 Gene_expression of JAG2 1 0.09 0.08 0.05
115 INT328345 Localization of JAG2 1 0.10 0.08 0.05
116 INT180108 Binding of Adam10 1 0.05 0 0.05
117 INT356055 Localization of Adam10 1 0.40 0.5 0.05
118 INT219231 Positive_regulation of Gene_expression of JAG1 1 0.40 1.18 0.05
119 INT356076 Negative_regulation of Localization of Adam10 1 0.23 0.51 0.05
120 INT328339 Binding of JAG2 1 0.06 0.09 0.05
121 INT356057 Positive_regulation of Positive_regulation of Adam10 1 0.32 0.25 0.05
122 INT193865 Protein_catabolism of Psen1 10 0.97 0.37 0.04
123 INT350959 Transcription of NOTCH1 2 0.05 0.84 0.03
124 INT219329 Transcription of NOTCH3 1 0.69 0.48 0.03
125 INT224302 Negative_regulation of Transcription of PSEN2 3 0.26 0.08 0
126 INT265229 Binding of PSEN2 2 0.16 1.37 0
127 INT320826 Positive_regulation of DLL4 1 0.39 0.41 0
128 INT286327 Regulation of Binding of Psen1 1 0.33 0.16 0
129 INT320829 Negative_regulation of DLL4 1 0.45 2.26 0
130 INT234250 Positive_regulation of Negative_regulation of PSEN1 1 0.41 0 0
131 INT230169 Positive_regulation of Gene_expression of NOTCH2 1 0.29 0.12 0
132 INT193886 Regulation of Protein_catabolism of Psen1 1 0.44 0.06 0
133 INT193934 Positive_regulation of Binding of PSEN1 1 0.49 0.92 0
134 INT224297 Regulation of Transcription of PSEN2 1 0.20 0.06 0
135 INT331407 Negative_regulation of Transcription of Psen1 1 0.04 0.08 0
136 INT300174 Negative_regulation of Gene_expression of NOTCH1 1 0.04 0.53 0
137 INT177774 Transcription of PSEN1 1 0.33 0.09 0
138 INT234247 Negative_regulation of Protein_catabolism of NOTCH1 1 0.05 0 0
139 INT320828 Regulation of DLL4 1 0.21 0.46 0
140 INT175419 Positive_regulation of Gene_expression of NOTCH3 1 0.32 3 0
141 INT130094 Regulation of Positive_regulation of NOTCH1 1 0.45 0.52 0
142 INT230170 Regulation of Localization of NOTCH2 1 0.26 0.05 0
143 INT286336 Positive_regulation of Gene_expression of PSENEN 1 0.10 0.39 0
144 INT257560 Regulation of Negative_regulation of JAG1 1 0.13 0.48 0
145 INT150261 Negative_regulation of Aph1a 1 0.00 0.37 0
146 INT286334 Localization of PSENEN 1 0.14 0.31 0
147 INT286335 Positive_regulation of Binding of PSENEN 1 0.10 0.15 0
148 INT230164 Localization of NOTCH2 1 0.44 0.17 0
149 INT286315 Positive_regulation of Gene_expression of Aph1a 1 0.19 0 0
150 INT354892 Negative_regulation of Psen2 1 0.37 0.95 0
151 INT193844 Positive_regulation of Protein_catabolism of Psen1 1 0.49 0.05 0
152 INT331463 Regulation of Gene_expression of PSEN2 1 0.04 0 0
153 INT234258 Negative_regulation of Phosphorylation of PSEN1 1 0.35 0.49 0
154 INT345243 Protein_catabolism of Adam10 1 0.44 0 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox