GO:0007224

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Name smoothened signaling pathway
Categary Process
Go Slim No
Go Link GO:0007224
Unique Molecular Interactions 386
Total Molecular Interactions 514
Total Single Events 1774
Pain Genes Associated 32

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for smoothened signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for smoothened signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
2 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
3 INT335404 Binding of Arntl and Hspg2 1 0.06 0.93 0.82
4 INT335403 Binding of Hspg2 and Npas2 1 0.04 0.93 0.82
5 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
6 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
7 INT261378 Nsdhl Negative_regulation of Gene_expression of Flvcr2 1 0.01 0.34 0.7
8 INT348129 Bgn Regulation of Regulation of Hspg2 1 0.00 0.69 0.69
9 INT68561 Binding of Gli3 and Ust 1 0.01 0.68 0.68
10 INT149899 Ihh Positive_regulation of Mmp7 1 0.04 1.69 0.65
11 INT139079 Tnip1 Negative_regulation of Ptch1 1 0.20 0.63 0.62
12 INT52478 Binding of Adarb1 and Ift172 1 0.00 0 0.62
13 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
14 INT149894 Ihh Positive_regulation of Localization of Mmp14 1 0.04 2.06 0.47
15 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
16 INT261374 Nsdhl Regulation of Esr2 1 0.05 0.76 0.41
17 INT261370 Nsdhl Regulation of Esr1 1 0.01 0.75 0.41
18 INT116936 Positive_regulation of GLI2 Positive_regulation of JUN 1 0.12 0.07 0.41
19 INT75489 Binding of SGCG and Tgfbr2 1 0.23 0.83 0.41
20 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41
21 INT297342 Binding of Gnb5 and Smo 1 0.02 1.67 0.34
22 INT149897 Ihh Positive_regulation of Mmp14 1 0.03 0.93 0.33
23 INT149896 Ihh Regulation of Gene_expression of Col1a1 1 0.06 0.89 0.33
24 INT149895 Ihh Regulation of Localization of Mmp7 1 0.03 0.98 0.33
25 INT149902 Ihh Positive_regulation of SGCG 1 0.45 0.76 0.32
26 INT149898 Ihh Regulation of Localization of Mmp14 1 0.03 1.29 0.27
27 INT295200 Hspg2 Positive_regulation of Tlr4 1 0.00 0 0.25
28 INT261375 Binding of Nsdhl and Pparg 1 0.05 1.03 0.25
29 INT70661 Binding of Hrasls and Nkx2-2 1 0.02 0 0.24
30 INT261394 Nsdhl Negative_regulation of nt 1 0.01 1.69 0.24
31 INT210798 Ihh Positive_regulation of Itgbl1 1 0.34 0 0.23
32 INT261389 Nsdhl Positive_regulation of Esr2 1 0.06 1.04 0.23
33 INT186957 Nsdhl Positive_regulation of Tmed4 1 0.04 0.71 0.23
34 INT104834 Binding of GLI2 and IGKV2OR2-1 1 0.00 0 0.22
35 INT149900 Gli1 Regulation of Localization of Mmp14 1 0.02 1.17 0.22
36 INT297545 Pou3f3 Regulation of Hes1 1 0.05 0.41 0.2
37 INT287894 VEGFA Positive_regulation of Localization of BMP4 1 0.04 2.49 0.2
38 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
39 INT261373 Nsdhl Positive_regulation of Gene_expression of Gfap 1 0.10 2.05 0.19
40 INT261387 Nsdhl Negative_regulation of Casp3 1 0.03 1.08 0.19
41 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
42 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
43 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
44 INT210795 Ihh Negative_regulation of Itgb1 1 0.30 0 0.17
45 INT303939 TRAP Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
46 INT303941 CCL2 Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
47 INT210782 Ihh Negative_regulation of Itgbl1 1 0.31 0 0.16
48 INT186954 Binding of Des and Nsdhl 1 0.06 0.32 0.16
49 INT210804 Ihh Negative_regulation of Timp4 1 0.32 0 0.16
50 INT104837 IGKV2OR2-1 Negative_regulation of GLI2 1 0.00 0 0.15
51 INT261384 Nsdhl Negative_regulation of Gene_expression of Mbp 1 0.01 1.43 0.14
52 INT261381 Nsdhl Regulation of Gene_expression of S100b 1 0.06 0.82 0.13
53 INT223535 Binding of HAND1 and Pax6 1 0.33 0.92 0.13
54 INT223526 Binding of Pax6 and Tcf3 1 0.33 0.92 0.13
55 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
56 INT261390 Binding of Nsdhl and Bdnf 1 0.05 1.33 0.12
57 INT261380 Nsdhl Negative_regulation of P4hb 1 0.02 1.36 0.11
58 INT261379 Nsdhl Positive_regulation of Thra 1 0.07 1.12 0.11
59 INT297548 Neurod1 Regulation of Hes1 1 0.05 0.2 0.1
60 INT24321 Pomc Positive_regulation of Localization of Gli1 1 0.07 0 0.1
61 INT261391 Binding of Nsdhl and P4hb 1 0.02 1.3 0.1
62 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1
63 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
64 INT165161 Ihh Positive_regulation of Sostdc1 1 0.58 0.07 0.09
65 INT165159 Gli1 Regulation of Penk 1 0.24 0.07 0.09
66 INT165160 Regulation of Ihh Positive_regulation of Sostdc1 1 0.23 0.07 0.09
67 INT261396 Nsdhl Positive_regulation of Transcription of Esr1 1 0.02 2.1 0.09
68 INT165158 Positive_regulation of Ihh Positive_regulation of Sostdc1 1 0.42 0.07 0.09
69 INT261371 Nsdhl Negative_regulation of Positive_regulation of Bdnf 1 0.06 1.18 0.09
70 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
71 INT165157 Gli1 Regulation of Igfbp5 1 0.24 0.07 0.09
72 INT270457 Binding of Ptch1 and Gli1 1 0.02 1.3 0.08
73 INT210788 Ihh Negative_regulation of Coro1a 1 0.02 0 0.08
74 INT213418 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of VCAM1 1 0.29 0.15 0.08
75 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
76 INT261376 Nsdhl Positive_regulation of Gene_expression of Nrgn 1 0.06 0.86 0.08
77 INT210790 Ihh Negative_regulation of Cdkn1c 1 0.30 0 0.08
78 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
79 INT210787 Ihh Negative_regulation of Nr3c1 1 0.33 0 0.08
80 INT213419 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of HGF 1 0.25 0.15 0.08
81 INT261386 Nsdhl Positive_regulation of Map2 1 0.08 0.59 0.07
82 INT261395 Nsdhl Positive_regulation of Syn1 1 0.00 0.59 0.07
83 INT261392 Binding of Nsdhl and Syn1 1 0.00 0.65 0.07
84 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
85 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
86 INT287223 Pdx1 Regulation of Transcription of Insig1 1 0.03 0.56 0.05
87 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05
88 INT343538 TGFB1 Positive_regulation of Gene_expression of GLI2 1 0.08 0.2 0.05
89 INT261385 LH Regulation of Localization of Nsdhl 1 0.02 0.65 0.05
90 INT261382 Nsdhl Regulation of Il6 1 0.03 0.66 0.04
91 INT262757 SMO Positive_regulation of Regulation of GLI1 1 0.34 0.6 0.04
92 INT133983 Pou2f1 Regulation of Pdx1 1 0.06 0 0.04
93 INT133989 Pdx1 Regulation of Kcnip3 1 0.07 0 0.04
94 INT133981 Pdx1 Regulation of Pou1f1 1 0.05 0 0.04
95 INT133982 Pou1f1 Regulation of Pdx1 1 0.05 0 0.04
96 INT261393 Binding of Nsdhl and Med1 1 0.02 1 0.04
97 INT133990 Meis1 Regulation of Pdx1 1 0.05 0 0.04
98 INT270458 Binding of Gli1 and Smo 1 0.00 0.65 0.04
99 INT134000 Pdx1 Regulation of Gene_expression of Npff 1 0.46 0 0.04
100 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
101 INT133978 Pdx1 Regulation of Pou2f1 1 0.06 0 0.04
102 INT261388 Nsdhl Regulation of Lif 1 0.08 0.67 0.04
103 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
104 INT134001 Kcnip3 Regulation of Pdx1 1 0.07 0 0.04
105 INT133996 Pdx1 Regulation of Meis1 1 0.05 0 0.04
106 INT261377 Nsdhl Positive_regulation of Lif 1 0.08 0.6 0.03
107 INT306560 BMP4 Positive_regulation of MAPK1 1 0.09 0.09 0.03
108 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
109 INT343545 Binding of GLI2 and ROCK1 1 0.07 0.65 0.03
110 INT255756 Ptch1 Positive_regulation of Phosphorylation of Pik3r1 1 0.16 1.08 0.03
111 INT255733 Ptch1 Positive_regulation of Pik3r1 1 0.16 1.08 0.03
112 INT337751 ADAMTS2 Positive_regulation of Gene_expression of Nkx6-1 1 0.04 0 0.03
113 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
114 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
115 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
116 INT261383 Nsdhl Positive_regulation of Gene_expression of Il4 1 0.03 0.46 0.03
117 INT186960 Positive_regulation of Nsdhl Positive_regulation of Tmed4 1 0.03 0.05 0.03
118 INT343544 Negative_regulation of GLI2 Negative_regulation of Gene_expression of PTHLH 1 0.24 0.53 0.03
119 INT261035 Hspg2 Positive_regulation of Gmcl1 1 0.01 0.4 0
120 INT283346 Binding of Srr and Kif3a 1 0.17 0 0
121 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
122 INT255758 Ptch1 Positive_regulation of Akt1 1 0.21 1.14 0
123 INT352148 Ift88 Negative_regulation of Bcl2l2 1 0.00 0.19 0
124 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
125 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
126 INT255732 Ptch1 Positive_regulation of hs 1 0.06 1.26 0
127 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
128 INT264735 Binding of Hes1 and Mir199b 1 0.08 0.93 0
129 INT205975 Binding of PTCH1 and Smo 1 0.02 0.72 0
130 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
131 INT264738 Mir199b Regulation of Gene_expression of Hes1 1 0.08 0.89 0
132 INT333294 Binding of Zic2 and Gli1 1 0.03 0 0
133 INT349315 Hspg2 Regulation of Gene_expression of Aif1 1 0.01 0 0
134 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
135 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
136 INT314773 Glp1r Positive_regulation of Gene_expression of Pdx1 1 0.01 0.57 0
137 INT197794 Negative_regulation of Pthlh Regulation of Ihh 1 0.36 1.33 0
138 INT255755 Ptch1 Regulation of Positive_regulation of Ins1 1 0.05 0.28 0
139 INT264736 Hes1 Regulation of Notch2 1 0.20 0.13 0
140 INT205974 Smo Positive_regulation of GLI1 1 0.04 0.66 0
141 INT205958 GLI1 Positive_regulation of Gene_expression of PTCH1 1 0.35 0.57 0
142 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
143 INT352525 SLC25A16 Negative_regulation of SMO 1 0.00 1.1 0
144 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
145 INT49943 Binding of Th and Pdx1 1 0.02 0.17 0
146 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
147 INT197316 Hes1 Regulation of Atoh1 1 0.01 0.14 0
148 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
149 INT289372 Negative_regulation of Gli1 Positive_regulation of cac 1 0.48 0.68 0
150 INT207374 Gene_expression of GLI2 Negative_regulation of Gene_expression of Chol1 1 0.04 0 0
151 INT255753 Ptch1 Positive_regulation of Phosphorylation of Gopc 1 0.13 1.33 0
152 INT205964 SMOX Positive_regulation of GLI1 1 0.20 0.66 0
153 INT185271 Pax6 Regulation of Psmd1 1 0.02 0 0
154 INT340919 Binding of Fkbp8 and Ptplad1 1 0.14 0.17 0
155 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
156 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
157 INT343548 GLI2 Positive_regulation of Gene_expression of PTHLH 1 0.28 0.94 0
158 INT197304 Ahr Regulation of Hes1 1 0.06 0.17 0
159 INT333293 Binding of Zic1 and Gli1 1 0.01 0 0
160 INT264731 Gene_expression of Hes1 Negative_regulation of Positive_regulation of Musd1 1 0.00 0.18 0
161 INT260074 Binding of BRCA2 and PTCH1 1 0.40 0.15 0
162 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0
163 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
164 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
165 INT343549 GLI2 Positive_regulation of GYPA 1 0.05 0.95 0
166 INT197315 Hes5 Regulation of Atoh1 1 0.00 0.14 0
167 INT255744 Binding of hs and Ptch1 1 0.06 1.32 0
168 INT240011 Ass1 Positive_regulation of Gene_expression of Nkx2-2 1 0.00 0 0
169 INT289373 Gli1 Positive_regulation of cac 1 0.52 0.68 0
170 INT205965 Binding of Ptch1 and Smo 1 0.03 0.72 0
171 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
172 INT255750 Ptch1 Positive_regulation of Ins1 1 0.10 0.35 0
173 INT196022 Bmp7 Regulation of Bmp4 1 0.06 0.06 0
174 INT260073 Binding of FANCC and PTCH1 1 0.33 0.49 0
175 INT207336 Gene_expression of GLI2 Negative_regulation of Gene_expression of CYP27A1 1 0.00 0 0
176 INT352150 Ift88 Negative_regulation of Bcl2 1 0.00 0.19 0
177 INT197314 Hes5 Regulation of Ascl1 1 0.00 0.14 0
178 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
179 INT264729 Mir199b Regulation of Hes1 1 0.05 0.25 0
180 INT260067 Binding of PTCH1 and XPA 1 0.26 1.08 0
181 INT205976 Binding of Ptch1 and SMOX 1 0.21 0.72 0
182 INT205962 Binding of PTCH1 and SMOX 1 0.14 0.72 0
183 INT255734 Ptch1 Regulation of Ins1 1 0.09 1.46 0
184 INT197310 Hes1 Regulation of Ascl1 1 0.01 0.14 0
185 INT270470 Shh Regulation of Gene_expression of VEGFA 1 0.39 0.15 0
186 INT264725 Binding of Hes1 and Notch1 1 0.03 0.84 0
187 INT255760 Ptch1 Regulation of TNF 1 0.13 1.33 0
188 INT255741 Ptch1 Positive_regulation of Phosphorylation of Ins1 1 0.09 2.21 0
189 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
190 INT264734 Mir199b Negative_regulation of Negative_regulation of Hes1 1 0.07 0.1 0
191 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
192 INT205961 GLI1 Positive_regulation of Negative_regulation of PTCH1 1 0.25 0.58 0
193 INT243232 Ighmbp2 Negative_regulation of Ptch1 1 0.02 0.22 0
194 INT255749 Ptch1 Positive_regulation of Phosphorylation of Slc2a4 1 0.15 1.32 0
195 INT270469 Shh Positive_regulation of VEGFA 1 0.29 0.12 0
196 INT255735 Ptch1 Positive_regulation of Phosphorylation of Akt1 1 0.27 2.83 0
197 INT343539 GLI2 Regulation of PTHLH 1 0.15 0.25 0
198 INT255746 Hspa1a Positive_regulation of Positive_regulation of Ptch1 1 0.19 0.99 0
199 INT352149 Ift88 Negative_regulation of Bcl2l1 1 0.00 0.19 0
200 INT255739 Ptch1 Positive_regulation of Gene_expression of Hspa1a 1 0.18 0.75 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for smoothened signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in smoothened signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48840 Gene_expression of Nkx2-2 8 0.23 1.55 5.44
2 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
3 INT37335 Gene_expression of Nsdhl 45 0.51 24.36 4.58
4 INT15257 Positive_regulation of Nkx2-2 10 0.21 1.75 4.2
5 INT51180 Regulation of Nkx2-2 5 0.26 2.16 4.14
6 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99
7 INT8600 Binding of Nkx2-2 6 0.10 0.87 3.82
8 INT75485 Gene_expression of Tgfbr2 10 0.57 10.98 3.76
9 INT238313 Gene_expression of Hspg2 9 0.58 3.42 3.15
10 INT7978 Positive_regulation of Nsdhl 9 0.43 5.6 2.63
11 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48
12 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02
13 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
14 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
15 INT90926 Positive_regulation of GLI2 12 0.45 4.99 1.74
16 INT112845 Negative_regulation of Binding of Nkx2-2 2 0.12 0.14 1.47
17 INT140245 Binding of Gli3 3 0.36 2.65 1.46
18 INT132081 Regulation of Gene_expression of Nkx2-2 2 0.10 0.24 1.43
19 INT113151 Positive_regulation of Ptch1 7 0.64 3.8 1.41
20 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29
21 INT104839 Negative_regulation of GLI2 8 0.35 2.7 1.24
22 INT174785 Localization of Hspg2 2 0.06 2.18 1.24
23 INT183068 Gene_expression of SMO 2 0.17 0.27 1.2
24 INT140983 Gene_expression of Ihh 7 0.78 2.06 1.15
25 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
26 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
27 INT119674 Localization of GLI2 6 0.52 2.84 0.99
28 INT182322 Negative_regulation of Gene_expression of GLI2 6 0.11 2.37 0.98
29 INT64173 Regulation of Gene_expression of GLI2 4 0.37 2.89 0.88
30 INT289474 Regulation of GLI2 2 0.06 1.08 0.87
31 INT135299 Binding of PTCH1 10 0.48 12.16 0.84
32 INT335364 Negative_regulation of Transcription of Hspg2 1 0.07 0.91 0.8
33 INT270447 Binding of Smo 2 0.07 2.61 0.78
34 INT335373 Transcription of Hspg2 1 0.08 0.86 0.77
35 INT138396 Transcription of Nkx2-2 1 0.26 0.05 0.75
36 INT138395 Positive_regulation of Transcription of Nkx2-2 1 0.19 0.05 0.75
37 INT142416 Binding of Ptch1 6 0.34 4.92 0.74
38 INT186941 Localization of Nsdhl 2 0.46 2.7 0.74
39 INT104840 Binding of GLI2 6 0.08 1.89 0.72
40 INT126376 Gene_expression of Gli1 8 0.68 4.52 0.7
41 INT68560 Regulation of Gli3 3 0.18 1.51 0.68
42 INT191225 Regulation of Hspg2 3 0.06 1.04 0.68
43 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67
44 INT264709 Gene_expression of Hes1 24 0.76 7.04 0.63
45 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
46 INT205957 Negative_regulation of Smo 4 0.08 2.57 0.6
47 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56
48 INT140984 Regulation of Ihh 5 0.54 2.81 0.56
49 INT133968 Binding of Pdx1 1 0.32 0.16 0.55
50 INT135062 Transcription of Gli3 1 0.05 0 0.52
51 INT158440 Negative_regulation of Nsdhl 4 0.21 3.22 0.51
52 INT24317 Gene_expression of Gli1 4 0.54 1.46 0.47
53 INT206484 Localization of Shh 2 0.75 1.14 0.46
54 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
55 INT256628 Regulation of Nsdhl 2 0.11 4.12 0.43
56 INT261353 Negative_regulation of Gene_expression of Nsdhl 1 0.17 0.71 0.43
57 INT48503 Positive_regulation of Positive_regulation of Nkx2-2 1 0.15 0 0.42
58 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
59 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
60 INT149890 Positive_regulation of Gene_expression of Gli1 1 0.48 1.56 0.41
61 INT7979 Binding of Nsdhl 6 0.30 3.71 0.4
62 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
63 INT120899 Positive_regulation of Gene_expression of Tgfbr2 1 0.29 0.46 0.38
64 INT186939 Positive_regulation of Positive_regulation of Nsdhl 2 0.31 0.86 0.34
65 INT40753 Gene_expression of GLI1 9 0.75 5.98 0.33
66 INT166716 Negative_regulation of Ihh 3 0.43 0.67 0.33
67 INT156399 Regulation of Pdx1 1 0.00 0.96 0.33
68 INT250036 Negative_regulation of Hspg2 2 0.05 0.57 0.32
69 INT122619 Gene_expression of Nkx2-2 6 0.36 0.15 0.31
70 INT356400 Transcription of Smo 1 0.02 0.05 0.3
71 INT119675 Positive_regulation of Localization of GLI2 1 0.32 0.43 0.3
72 INT24320 Localization of Gli1 6 0.77 0.63 0.29
73 INT277474 Positive_regulation of Gene_expression of SMO 1 0.11 0 0.29
74 INT159213 Gene_expression of BMP4 8 0.74 2.1 0.28
75 INT159212 Positive_regulation of Gene_expression of BMP4 2 0.66 0.91 0.28
76 INT234407 Positive_regulation of Binding of GLI2 2 0.05 1.33 0.28
77 INT216120 Negative_regulation of SMO 2 0.49 3.05 0.27
78 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26
79 INT49942 Positive_regulation of Pdx1 5 0.02 1.24 0.26
80 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
81 INT149893 Positive_regulation of Gene_expression of Ihh 1 0.69 0.62 0.26
82 INT208497 Localization of Nkx2-2 1 0.01 0 0.26
83 INT149892 Gene_expression of Ihh 1 0.77 0.61 0.26
84 INT165153 Positive_regulation of Gli1 4 0.59 1.17 0.25
85 INT185009 Negative_regulation of BMP4 2 0.56 1.04 0.25
86 INT332230 Regulation of Pdx1 1 0.01 0.99 0.25
87 INT135061 Protein_catabolism of Gli3 1 0.04 0 0.25
88 INT174925 Binding of Hspg2 3 0.05 1.11 0.24
89 INT181158 Positive_regulation of Hspg2 2 0.03 1.01 0.23
90 INT140639 Gene_expression of FOXF1 3 0.52 0.89 0.22
91 INT303943 Protein_catabolism of GLI2 2 0.11 0 0.22
92 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
93 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
94 INT149888 Localization of Ihh 1 0.75 0.77 0.2
95 INT24316 Regulation of Localization of Gli1 1 0.51 0 0.19
96 INT135060 Negative_regulation of Transcription of Gli3 1 0.03 0 0.19
97 INT264701 Negative_regulation of Gene_expression of Hes1 1 0.42 0.73 0.18
98 INT185254 Gene_expression of Pax6 14 0.72 1.77 0.16
99 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
100 INT182321 Positive_regulation of Gene_expression of GLI2 2 0.28 1.32 0.16
101 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
102 INT149891 Negative_regulation of Gene_expression of Gli1 1 0.41 0.68 0.14
103 INT249096 Regulation of FOXF1 1 0.19 0.28 0.14
104 INT253190 Localization of Shh 2 0.77 1.06 0.13
105 INT206915 Regulation of Gene_expression of Nsdhl 2 0.22 1 0.13
106 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
107 INT270451 Localization of Gli3 1 0.26 0.63 0.11
108 INT213448 Localization of FOXF1 1 0.58 0.15 0.1
109 INT287912 Localization of BMP4 1 0.18 1.13 0.1
110 INT260083 Regulation of PTCH1 11 0.27 4.46 0.09
111 INT196033 Negative_regulation of Gene_expression of Bmp4 3 0.21 0.45 0.09
112 INT206912 Positive_regulation of Gene_expression of Nsdhl 2 0.25 1.59 0.09
113 INT270454 Regulation of Transcription of Ptch1 1 0.25 0.55 0.09
114 INT123875 Localization of Pdx1 1 0.80 0.28 0.09
115 INT270442 Transcription of Shh 1 0.53 0.25 0.09
116 INT24318 Regulation of Gene_expression of Gli1 1 0.23 0 0.09
117 INT135063 Regulation of Gene_expression of Gli3 1 0.04 0 0.09
118 INT70606 Positive_regulation of Positive_regulation of Pdx1 1 0.02 0.4 0.09
119 INT270450 Transcription of Ptch1 1 0.49 0.55 0.09
120 INT213515 Binding of Shh 8 0.37 1.92 0.08
121 INT202629 Gene_expression of Pdx1 8 0.60 4.09 0.08
122 INT165148 Regulation of Binding of Ptch1 1 0.22 0.08 0.08
123 INT270453 Regulation of Shh 1 0.27 0.83 0.08
124 INT213440 Negative_regulation of FOXF1 1 0.33 0.14 0.08
125 INT126375 Negative_regulation of Gene_expression of Gli3 1 0.58 0.79 0.08
126 INT270452 Regulation of Gene_expression of Ptch1 1 0.25 0.25 0.08
127 INT352606 Localization of Gli1 1 0.38 1.19 0.08
128 INT202649 Positive_regulation of Pdx1 3 0.45 1.45 0.07
129 INT205973 Binding of SHH 3 0.35 1.03 0.07
130 INT165151 Negative_regulation of Positive_regulation of Gli1 1 0.50 0.09 0.07
131 INT168919 Regulation of Regulation of Ihh 1 0.40 0.43 0.07
132 INT256862 Regulation of Shh 1 0.25 0 0.07
133 INT165154 Negative_regulation of Positive_regulation of Ptch1 1 0.34 0.09 0.07
134 INT183056 Positive_regulation of Transcription of PTCH1 1 0.28 0.46 0.07
135 INT298251 Gene_expression of Hes5 2 0.45 0.39 0.06
136 INT345344 Regulation of SMO 1 0.23 1.07 0.06
137 INT255719 Phosphorylation of Ptch1 1 0.32 3.7 0.06
138 INT238307 Positive_regulation of Gene_expression of Hspg2 1 0.04 0.13 0.06
139 INT290112 Positive_regulation of Gene_expression of Gli1 1 0.50 1.09 0.05
140 INT290114 Negative_regulation of Gene_expression of Gli1 1 0.31 1.09 0.05
141 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
142 INT352129 Negative_regulation of Ift88 1 0.00 0.72 0.05
143 INT255726 Localization of Ptch1 1 0.33 1.74 0.05
144 INT262772 Binding of SMO 1 0.27 0.59 0.05
145 INT249943 Positive_regulation of Binding of Hspg2 1 0.03 0.28 0.05
146 INT196030 Positive_regulation of Bmp4 6 0.62 2.55 0.04
147 INT205969 Regulation of GLI1 4 0.41 3.09 0.04
148 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
149 INT183070 Transcription of PTCH1 2 0.68 0.95 0.04
150 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
151 INT262777 Localization of SMO 1 0.59 0.6 0.04
152 INT174784 Regulation of Localization of Hspg2 1 0.02 0.51 0.04
153 INT352603 Negative_regulation of Localization of Gli1 1 0.18 0.6 0.04
154 INT270456 Positive_regulation of Gli1 1 0.02 0.62 0.04
155 INT122620 Negative_regulation of Gene_expression of Nkx2-2 1 0.20 0 0.04
156 INT253182 Positive_regulation of Positive_regulation of Bmp4 1 0.45 0.58 0.04
157 INT352604 Regulation of Gli1 1 0.21 0.6 0.04
158 INT165149 Positive_regulation of Ihh 1 0.42 0.09 0.04
159 INT264717 Negative_regulation of Hes1 7 0.42 0.77 0.03
160 INT264704 Regulation of Hes1 4 0.44 1.03 0.03
161 INT244776 Gene_expression of Nkx6-1 2 0.75 0 0.03
162 INT206481 Transcription of Pax6 2 0.41 0.19 0.03
163 INT336419 Negative_regulation of Gene_expression of Pax6 1 0.45 0.12 0.03
164 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
165 INT283314 Localization of Kif3a 1 0.69 0 0.03
166 INT183064 Regulation of Gene_expression of PTCH1 1 0.34 0.22 0.03
167 INT253181 Transcription of Shh 1 0.68 0.54 0.03
168 INT264702 Positive_regulation of Gene_expression of Hes1 1 0.68 1.39 0.03
169 INT97829 Gene_expression of Pdx1 7 0.32 1.14 0
170 INT196034 Positive_regulation of Gene_expression of Bmp4 4 0.45 0.63 0
171 INT260779 Negative_regulation of Bmp4 4 0.23 0.94 0
172 INT205968 Negative_regulation of PTCH1 2 0.58 2.35 0
173 INT255723 Positive_regulation of Gene_expression of Ptch1 2 0.39 1.3 0
174 INT264719 Regulation of Gene_expression of Hes1 2 0.28 0.12 0
175 INT196027 Binding of Bmp4 2 0.13 0.97 0
176 INT246011 Transcription of Gli1 2 0.29 0 0
177 INT256631 Positive_regulation of PTCH1 2 0.13 1.97 0
178 INT291889 Negative_regulation of Pax6 2 0.45 0.39 0
179 INT205972 Regulation of Gene_expression of GLI1 1 0.41 1.17 0
180 INT268585 Negative_regulation of Gene_expression of GLI1 1 0.24 1.01 0
181 INT238312 Negative_regulation of Gene_expression of Hspg2 1 0.04 0.3 0
182 INT264708 Transcription of Hes1 1 0.67 0.83 0
183 INT132735 Positive_regulation of Gene_expression of Pdx1 1 0.29 0 0
184 INT202631 Transcription of Pdx1 1 0.48 0 0
185 INT260088 Negative_regulation of Transcription of PTCH1 1 0.43 0.4 0
186 INT252242 Gene_expression of Smo 1 0.01 0.23 0
187 INT207371 Positive_regulation of Transcription of GLI2 1 0.03 0.08 0
188 INT283316 Gene_expression of Kif3a 1 0.55 0 0
189 INT206914 Regulation of Localization of Nsdhl 1 0.22 0.46 0
190 INT286555 Binding of Ift88 1 0.30 0.08 0
191 INT322888 Negative_regulation of Ihh 1 0.26 0.45 0
192 INT324196 Positive_regulation of Gene_expression of Pax6 1 0.36 0 0
193 INT49941 Negative_regulation of Pdx1 1 0.02 0.07 0
194 INT291888 Regulation of Gene_expression of Pax6 1 0.33 0 0
195 INT260089 Localization of PTCH1 1 0.70 0.37 0
196 INT49938 Negative_regulation of Positive_regulation of Pdx1 1 0.02 0.07 0
197 INT143655 Transcription of Nkx2-2 1 0.58 0 0
198 INT264705 Binding of Hes1 1 0.35 0.07 0
199 INT310177 Binding of Tgfbr2 1 0.24 0 0
200 INT283315 Positive_regulation of Kif3a 1 0.46 0 0
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