GO:0007229

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Name integrin-mediated signaling pathway
Categary Process
Go Slim No
Go Link GO:0007229
Unique Molecular Interactions 528
Total Molecular Interactions 711
Total Single Events 5939
Pain Genes Associated 78

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for integrin-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for integrin-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT81708 POMC Regulation of Gene_expression of ITGAM 1 0.53 0.72 3.1
2 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81
3 INT107268 Binding of ITGAL and NCR3 1 0.01 2.76 2.07
4 INT100771 Binding of Itga1 and Vcam1 3 0.11 3.91 1.79
5 INT6407 Binding of Lama5 and Oprm1 1 0.02 0.08 1.72
6 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
7 INT81709 POMC Regulation of Gene_expression of ITGB2 1 0.40 0.34 1.57
8 INT81719 POMC Regulation of Gene_expression of ITGAL 1 0.35 0.34 1.57
9 INT81715 POMC Regulation of ITGB2 1 0.40 0.34 1.55
10 INT81721 POMC Regulation of ITGAM 1 0.39 0.34 1.55
11 INT81714 POMC Regulation of ITGAL 1 0.15 0.34 1.54
12 INT107265 Binding of HLA-DRB1 and ITGAL 1 0.01 1.41 1.1
13 INT71176 Binding of ICAM1 and ITGB2 4 0.21 4.93 1.07
14 INT102690 IL1B Positive_regulation of ITGAL 1 0.05 0.87 0.99
15 INT124918 Binding of PLEK and Maob 1 0.10 1.05 0.98
16 INT272984 Il6 Positive_regulation of Gene_expression of Itgam 1 0.24 0.78 0.96
17 INT48381 CSF2 Positive_regulation of ITGAM 2 0.30 0.38 0.95
18 INT253836 Cck Regulation of DST 1 0.03 0.42 0.95
19 INT116930 OPRK1 Positive_regulation of Binding of PTK2 1 0.28 0.35 0.93
20 INT116109 VEGFA Positive_regulation of PTK2 1 0.13 0.3 0.83
21 INT81716 ITGAL Regulation of ITGB2 2 0.30 1.24 0.78
22 INT81717 ITGAL Regulation of Gene_expression of ITGAM 1 0.30 0.17 0.78
23 INT81718 ITGAL Regulation of Gene_expression of FCGR3B 1 0.28 0.17 0.78
24 INT81711 ITGAL Regulation of Gene_expression of ITGB2 1 0.30 0.17 0.78
25 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
26 INT113546 Binding of FN1 and ITGA3 1 0.03 2.12 0.77
27 INT81713 ITGAL Regulation of ITGAM 1 0.30 0.17 0.77
28 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77
29 INT170127 Binding of ITGAL and PECAM1 2 0.01 2.71 0.75
30 INT259556 PLEK Negative_regulation of Gene_expression of VEGFA 1 0.46 2.15 0.73
31 INT259557 PLEK Negative_regulation of Positive_regulation of VEGFA 1 0.46 2.15 0.73
32 INT48386 CSF2 Positive_regulation of Positive_regulation of ITGAM 1 0.16 0.24 0.7
33 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
34 INT104301 Adam17 Regulation of Negative_regulation of Sell 1 0.39 0.58 0.69
35 INT48385 CSF2 Regulation of Gene_expression of ITGAM 2 0.16 0.29 0.68
36 INT28080 POMC Negative_regulation of Gene_expression of ITGAM 1 0.00 0.16 0.65
37 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
38 INT48304 Positive_regulation of MBP Positive_regulation of PLP1 1 0.10 0.97 0.64
39 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
40 INT48303 MBP Positive_regulation of PLP1 1 0.10 0.97 0.64
41 INT265651 Binding of ITGAL and MYCN 1 0.00 0.46 0.62
42 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
43 INT277828 Negative_regulation of Binding of ICAM1 and ITGAL 2 0.22 1.27 0.57
44 INT253835 Binding of DST and Fos 1 0.02 0 0.55
45 INT266376 Binding of Ager and Itgam 1 0.00 2.31 0.54
46 INT167194 FPR1 Positive_regulation of Gene_expression of ITGAM 1 0.52 0.8 0.53
47 INT182813 EEF1A2 Negative_regulation of ITGAL 1 0.10 1.53 0.51
48 INT301285 Binding of Tyrobp and Clec5a 1 0.32 1.63 0.49
49 INT48382 CSF2 Positive_regulation of Gene_expression of ITGAM 1 0.23 0.25 0.49
50 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
51 INT352892 Binding of CAV1 and ITGA2 1 0.20 1.61 0.47
52 INT71178 Binding of ITGB2 and Icam1 1 0.45 1.2 0.47
53 INT116935 Positive_regulation of OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.47
54 INT173475 Bcar1 Regulation of Isl1 1 0.01 0 0.47
55 INT116939 OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.46
56 INT187099 Binding of Cd4 and Itga1 1 0.00 1.09 0.46
57 INT116928 PTK2 Positive_regulation of JUN 1 0.20 0.15 0.46
58 INT117776 Binding of Ptk2 and Regulation of Phosphorylation of Ddr1 1 0.10 0.17 0.46
59 INT102691 RETNLB Positive_regulation of ITGAL 1 0.01 0.45 0.45
60 INT48388 CSF3 Regulation of Gene_expression of ITGAM 1 0.35 0.2 0.44
61 INT48383 CSF2 Regulation of Gene_expression of ITGB2 1 0.11 0.2 0.44
62 INT48389 CSF3 Regulation of Gene_expression of ITGB2 1 0.25 0.2 0.44
63 INT332248 Ccl2 Positive_regulation of Ctgf 1 0.04 1.13 0.42
64 INT244421 Binding of DST and Ctss 1 0.02 0.42 0.41
65 INT67633 Binding of DST and Gabrd 1 0.03 0 0.41
66 INT51829 Binding of ITGA2B and ANGPTL5 1 0.35 1.08 0.4
67 INT310600 Tbxa2r Positive_regulation of PLEK 1 0.53 0.45 0.38
68 INT139566 Binding of PLEK and Tbxa2r 1 0.01 1.14 0.38
69 INT180442 Acot1 Positive_regulation of Rhoa 1 0.08 1.03 0.38
70 INT113551 Binding of ITGA3 and VTN 1 0.02 1.03 0.38
71 INT161009 Binding of Cpe and Itgam 1 0.03 0.53 0.37
72 INT161006 Itgam Regulation of Cpb2 1 0.07 0.52 0.37
73 INT161003 Binding of Itgam and Cpb2 1 0.10 0.52 0.37
74 INT161001 Itgam Regulation of Gfap 1 0.13 0.52 0.37
75 INT161002 Binding of Itgam and St13 1 0.11 0.52 0.37
76 INT161008 Itgam Regulation of St13 1 0.08 0.52 0.37
77 INT96158 Itgax Regulation of Gene_expression of H2-D1 1 0.14 0.09 0.35
78 INT173476 Th Regulation of Gene_expression of Bcar1 1 0.10 0 0.34
79 INT23882 Npy Positive_regulation of Bcar1 1 0.34 0.67 0.34
80 INT206608 Binding of Ecm1 and Itgb5 1 0.02 0.41 0.33
81 INT265139 Binding of Calm2 and Cib1 1 0.00 0 0.33
82 INT61266 Nfkb1 Regulation of Gene_expression of Itgam 1 0.23 0.65 0.32
83 INT174658 TNF Positive_regulation of Gene_expression of ITGAM 1 0.16 1.54 0.3
84 INT102849 Tgfb1 Positive_regulation of Gene_expression of Col3a1 1 0.04 0.85 0.3
85 INT244422 Binding of DST and Fig4 1 0.01 0.42 0.29
86 INT179838 Col3a1 Regulation of Negative_regulation of Il11 1 0.21 0 0.29
87 INT319221 FSIP1 Regulation of ADAM33 1 0.31 1.47 0.29
88 INT295360 Ntn1 Positive_regulation of Ptk2 1 0.09 0.51 0.29
89 INT170128 Binding of ITGAL and ITGB2 2 0.04 1.6 0.28
90 INT291641 Binding of DST and ESRRG 1 0.16 1.8 0.28
91 INT180245 Binding of Plp1 and Uchl1 1 0.03 0.47 0.27
92 INT235013 Binding of DSG1 and Adam17 1 0.07 1.34 0.26
93 INT234980 Positive_regulation of Egfr Positive_regulation of Adam17 1 0.09 1.33 0.26
94 INT164636 Negative_regulation of CSF2 Positive_regulation of ITGAM 1 0.26 0.14 0.25
95 INT302818 Gcat Negative_regulation of Syk 1 0.00 0.53 0.24
96 INT316815 Ctgf Negative_regulation of Gene_expression of Sparc 1 0.47 0.64 0.24
97 INT352081 Binding of CD4 and ADAM11 1 0.09 0.33 0.24
98 INT210798 Ihh Positive_regulation of Itgbl1 1 0.34 0 0.23
99 INT63420 F2 Positive_regulation of Gene_expression of ITGA2B 1 0.14 0.45 0.23
100 INT210785 Cdkn1c Positive_regulation of Itgbl1 1 0.38 0 0.23
101 INT210794 Timp4 Positive_regulation of Itgbl1 1 0.40 0 0.23
102 INT20403 FPR1 Positive_regulation of Itgax 1 0.02 0.22 0.22
103 INT285639 Col3a1 Regulation of Tnfrsf12a 1 0.19 0.16 0.22
104 INT224454 TNF Positive_regulation of Gene_expression of Itgam 1 0.27 0.35 0.22
105 INT224445 Il1 Positive_regulation of Gene_expression of Itgam 1 0.21 0.35 0.22
106 INT180248 Binding of Gad1 and Plp1 1 0.08 0.22 0.21
107 INT283858 Binding of PTK2 and APOA5 1 0.00 0.67 0.21
108 INT336946 Binding of ITGA4 and VCAM1 1 0.03 2.02 0.21
109 INT125153 IL1B Regulation of ITGB2 1 0.22 0.1 0.2
110 INT236362 Binding of Gfap and Itgam 1 0.23 2.31 0.2
111 INT125154 IL1B Regulation of Gene_expression of ITGB2 1 0.50 0.1 0.2
112 INT125155 IL1B Regulation of ITGAM 1 0.49 0.1 0.2
113 INT51830 Positive_regulation of Binding of ITGA2B and ANGPTL5 1 0.51 0.57 0.2
114 INT51828 Negative_regulation of Binding of ITGA2B and ANGPTL5 1 0.31 0.51 0.2
115 INT92691 Tgfb1 Positive_regulation of Ctgf 1 0.16 0.91 0.2
116 INT125156 IL1B Regulation of Gene_expression of ITGAM 1 0.49 0.1 0.2
117 INT178086 Binding of EDNRA and PTK2 1 0.07 0.82 0.2
118 INT93648 Adp Positive_regulation of ITGA2B 1 0.00 0.79 0.2
119 INT303979 Lep Positive_regulation of ITGB2 1 0.11 0.35 0.2
120 INT180435 Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
121 INT291642 Binding of DST and GGT1 1 0.00 1.4 0.19
122 INT180444 Positive_regulation of Acot1 Positive_regulation of Rhoa 1 0.08 0.43 0.19
123 INT92694 Tgfb1 Positive_regulation of Positive_regulation of Col3a1 1 0.31 0.89 0.19
124 INT153457 Tgfb1 Positive_regulation of Gene_expression of Ctgf 1 0.13 1.15 0.19
125 INT153460 Inhba Positive_regulation of Gene_expression of Ctgf 1 0.77 1.14 0.19
126 INT319311 Binding of Glud1 and Ptk2b 1 0.36 0 0.19
127 INT180437 Positive_regulation of Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
128 INT153461 Tnf Positive_regulation of Gene_expression of Ctgf 1 0.48 1.13 0.19
129 INT139565 Negative_regulation of Binding of PLEK and Tbxa2r 1 0.01 0.57 0.19
130 INT182151 ITGAX Positive_regulation of Binding of IFNA1 1 0.05 0.46 0.18
131 INT214170 Binding of DST and Lep 1 0.02 0.17 0.18
132 INT99013 Binding of Itgb2 and Selp 1 0.16 1.36 0.18
133 INT99006 Regulation of Binding of Selp and Itga1 1 0.06 1.36 0.18
134 INT304964 Binding of AMT and PTK2B 1 0.23 0.78 0.18
135 INT99012 Binding of Selp and Itga1 1 0.05 1.36 0.18
136 INT182157 ITGAX Positive_regulation of IFNA1 1 0.05 0.46 0.18
137 INT99011 Regulation of Binding of Itgb2 and Selp 1 0.19 1.37 0.18
138 INT182155 DCPS Positive_regulation of Positive_regulation of ITGAX 1 0.04 0.46 0.18
139 INT178092 EDN3 Positive_regulation of PTK2 1 0.01 1.02 0.17
140 INT300305 Mapk14 Positive_regulation of Gene_expression of Ctgf 1 0.19 1.25 0.17
141 INT210795 Ihh Negative_regulation of Itgb1 1 0.30 0 0.17
142 INT314534 Ptger2 Regulation of Gene_expression of Itgam 1 0.02 1 0.17
143 INT178073 EDN1 Positive_regulation of PTK2 1 0.03 1.02 0.17
144 INT277791 Binding of Icam1 and Itgal 1 0.03 0.37 0.17
145 INT274353 DST Regulation of Gopc 1 0.00 0 0.17
146 INT67158 Binding of ITGA4 and Vcam1 1 0.00 0.2 0.17
147 INT316123 Binding of HLA-DRA and BCAR1 1 0.02 0.48 0.16
148 INT231677 Binding of CD47 and THBS1 1 0.18 0 0.16
149 INT101725 Binding of ITGA4 and Chrna7 1 0.00 0 0.16
150 INT210782 Ihh Negative_regulation of Itgbl1 1 0.31 0 0.16
151 INT273714 Positive_regulation of Binding of Icam1 and Itgb2 1 0.17 1.46 0.15
152 INT278373 Myd88 Regulation of Phosphorylation of Syk 1 0.15 0.35 0.15
153 INT293698 Positive_regulation of Binding of Akt1 and Plek 1 0.05 0.12 0.15
154 INT293695 Binding of Akt1 and Plek 1 0.03 0.12 0.15
155 INT281302 Binding of Itgam and Fgg 1 0.00 0.62 0.15
156 INT304169 Il33 Positive_regulation of Gene_expression of Itgam 1 0.02 1.18 0.15
157 INT153458 Ctgf Positive_regulation of Gene_expression of Il6 1 0.34 1.03 0.15
158 INT293699 Regulation of Binding of Akt1 and Plek 1 0.04 0.12 0.15
159 INT273717 Binding of Icam1 and Itgb2 1 0.17 1.45 0.15
160 INT128903 Binding of RNASE2 and Itga7 1 0.00 0.08 0.15
161 INT279031 Binding of Sirpa and Cd47 1 0.09 0.77 0.15
162 INT281315 Binding of Gp1bb and Itgam 1 0.00 0.62 0.15
163 INT58187 ITGA1 Positive_regulation of Itga3 1 0.01 1.47 0.14
164 INT319314 Binding of Ptk2b and Rbm39 1 0.01 0.08 0.14
165 INT147727 Phosphorylation of PTK2 Regulation of Positive_regulation of RAC1 1 0.34 0.32 0.14
166 INT327879 Binding of Itgb1 and Postn 1 0.02 1.05 0.14
167 INT291644 Binding of DST and ESR1 1 0.05 0.84 0.14
168 INT238333 Binding of PDGFA and Regulation of Gene_expression of ADAMTS1 1 0.06 0 0.14
169 INT319316 Binding of GRIN1 and Ptk2b 1 0.52 0.08 0.14
170 INT238341 GOPC Regulation of Transcription of ADAMTS1 1 0.04 0 0.14
171 INT147726 Phosphorylation of PTK2 Regulation of Positive_regulation of PIK3CA 1 0.09 0.32 0.14
172 INT238342 Binding of EGF and Regulation of Gene_expression of ADAMTS1 1 0.05 0 0.14
173 INT180447 Binding of Rhoa and Car2 1 0.17 0.56 0.13
174 INT241454 Rgnef Positive_regulation of Positive_regulation of Rhoa 1 0.04 0.11 0.13
175 INT275983 Binding of Lat and Lcp2 1 0.23 0.41 0.13
176 INT327877 Itgb1 Negative_regulation of Gene_expression of Dlk1 1 0.02 0.99 0.13
177 INT173406 Binding of ITGAL and Itgb2 1 0.02 0.41 0.13
178 INT352073 Positive_regulation of Binding of ADAM11 and CCL19 1 0.22 1.27 0.13
179 INT352080 Binding of ADAM11 and CCL19 1 0.16 1.27 0.13
180 INT157602 Binding of COL1A1 and COL3A1 1 0.04 0 0.13
181 INT326387 Binding of PROC and Rhoa 1 0.00 0.59 0.12
182 INT171792 GPER Regulation of Gene_expression of Itga2 1 0.00 0.54 0.12
183 INT241446 Rgnef Positive_regulation of Rhoa 1 0.04 0.1 0.12
184 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11
185 INT259629 Binding of Adam17 and Timp3 1 0.01 0.19 0.11
186 INT265919 Binding of PLEK and Adp 1 0.01 0.38 0.11
187 INT271525 ITGB1 Positive_regulation of Gopc 1 0.02 0.57 0.11
188 INT352084 AGRP Negative_regulation of Negative_regulation of ADAM11 1 0.06 0.98 0.11
189 INT327405 Lox Positive_regulation of Ptk2 1 0.42 1.3 0.1
190 INT206056 PTK2B Negative_regulation of Positive_regulation of IRF6 1 0.00 0.66 0.1
191 INT275451 Binding of ZAP70 and Syk 1 0.02 0.12 0.1
192 INT275450 Binding of STAM and Syk 1 0.00 0.12 0.1
193 INT266373 Itgam Positive_regulation of Ager 1 0.01 0.84 0.1
194 INT119454 Regulation of Binding of Itga2b and Gtf3a 1 0.00 0.14 0.1
195 INT119455 Binding of Itga2b and Gtf3a 1 0.00 0.14 0.1
196 INT236318 IGKV2D-38 Positive_regulation of ITGAM 1 0.01 0.13 0.1
197 INT272389 Bcar1 Negative_regulation of Gene_expression of Trpv6 1 0.01 0 0.1
198 INT119456 Binding of Itga2b and Fgg 1 0.00 0.14 0.1
199 INT180449 Rhoa Regulation of Positive_regulation of Car2 1 0.13 0 0.09
200 INT232652 Binding of CD2 and ITGAL 1 0.03 0.28 0.09

Single Events

The table below shows the top 100 pain related interactions that have been reported for integrin-mediated signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in integrin-mediated signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78
2 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26
3 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52
4 INT10918 Gene_expression of ITGB2 93 0.76 71.8 16.34
5 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47
6 INT146197 Positive_regulation of Rhoa 60 0.68 34.12 12.02
7 INT92686 Gene_expression of Ctgf 51 0.77 34.4 11.93
8 INT18412 Binding of PLEK 49 0.47 17.82 10.72
9 INT15172 Positive_regulation of Itgam 45 0.67 23.54 10.3
10 INT67048 Gene_expression of ITGA4 58 0.75 28.93 10.16
11 INT67101 Gene_expression of DST 47 0.54 25.92 9.59
12 INT3366 Localization of PLEK 44 0.78 15.83 9.55
13 INT10969 Positive_regulation of PLEK 33 0.67 16.96 8.35
14 INT12975 Regulation of PLEK 21 0.60 13.62 8.28
15 INT64792 Positive_regulation of Gene_expression of ITGAM 39 0.69 23.21 6.71
16 INT10917 Positive_regulation of ITGAM 31 0.67 16.39 6.69
17 INT38644 Positive_regulation of DST 30 0.53 12.48 6.59
18 INT60700 Gene_expression of Itgax 93 0.71 51.89 6.57
19 INT38595 Localization of BCAR1 8 0.73 2.9 6.25
20 INT61417 Gene_expression of ITGAL 36 0.75 29.62 6.15
21 INT48308 Binding of PLP1 7 0.48 9.59 6.09
22 INT83597 Phosphorylation of Ptk2 20 0.82 3.24 5.7
23 INT53684 Negative_regulation of Gene_expression of ITGAM 23 0.59 14.36 5.66
24 INT10919 Positive_regulation of ITGB2 25 0.67 13.75 5.45
25 INT15173 Positive_regulation of Gene_expression of Itgam 59 0.49 21.89 5.43
26 INT56364 Regulation of Gene_expression of ITGAM 19 0.61 9.82 5.09
27 INT48307 Positive_regulation of PLP1 5 0.66 8.42 5.09
28 INT61252 Negative_regulation of Gene_expression of Itgam 38 0.54 16.48 5.01
29 INT49405 Gene_expression of Itgal 40 0.75 27.3 4.8
30 INT48246 Gene_expression of PLP1 18 0.64 10.33 4.73
31 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72
32 INT87322 Binding of ITGAL 23 0.47 15.73 4.68
33 INT1807 Negative_regulation of Bcar1 9 0.38 4.04 4.59
34 INT92682 Positive_regulation of Gene_expression of Ctgf 17 0.69 12.16 4.51
35 INT57338 Gene_expression of ITGAX 31 0.75 24.62 4.39
36 INT104299 Negative_regulation of Adam17 18 0.47 12.03 4.39
37 INT22973 Gene_expression of Col3a1 22 0.42 15.85 4.32
38 INT87345 Phosphorylation of PTK2 110 0.82 59.39 4.28
39 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02
40 INT51831 Negative_regulation of ITGA2B 20 0.57 10.59 3.91
41 INT70326 Positive_regulation of Gene_expression of ITGB2 24 0.67 15.42 3.86
42 INT117773 Positive_regulation of Phosphorylation of Ptk2 9 0.69 0.89 3.71
43 INT11761 Negative_regulation of DST 13 0.42 7.66 3.65
44 INT33739 Gene_expression of ITGA2B 25 0.75 8.19 3.6
45 INT223134 Positive_regulation of Cib1 1 0.02 1.94 3.55
46 INT102076 Regulation of DST 15 0.22 10 3.5
47 INT92681 Positive_regulation of Ctgf 13 0.69 9.78 3.47
48 INT113604 Negative_regulation of Gene_expression of Ctgf 19 0.58 9.37 3.43
49 INT61259 Negative_regulation of Itgam 16 0.47 11.11 3.27
50 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23
51 INT146194 Negative_regulation of Rhoa 21 0.42 11.05 3.22
52 INT53683 Negative_regulation of Gene_expression of ITGB2 10 0.57 9.11 3.2
53 INT36032 Gene_expression of Col3a1 23 0.72 10.55 3.18
54 INT38594 Positive_regulation of Localization of BCAR1 3 0.63 0.44 3.07
55 INT67333 Negative_regulation of ITGB2 10 0.41 6.92 3.06
56 INT146191 Gene_expression of Rhoa 32 0.67 17.63 2.92
57 INT15178 Positive_regulation of Positive_regulation of ITGAM 7 0.56 2.51 2.86
58 INT102157 Gene_expression of Adam17 3 0.58 4.17 2.86
59 INT171117 Binding of Itgam 35 0.36 14.87 2.76
60 INT15555 Localization of PLP1 6 0.60 3.35 2.75
61 INT87340 Negative_regulation of BCAR1 8 0.38 6.96 2.63
62 INT30001 Negative_regulation of Gene_expression of PLEK 8 0.57 3.31 2.47
63 INT48391 Negative_regulation of Positive_regulation of ITGAM 5 0.43 3.13 2.46
64 INT61378 Positive_regulation of Bcar1 13 0.45 2.84 2.45
65 INT140091 Gene_expression of Ctgf 26 0.78 14.21 2.39
66 INT88586 Positive_regulation of Itga7 4 0.67 0.89 2.36
67 INT61418 Positive_regulation of ITGAL 24 0.14 12.86 2.3
68 INT146196 Localization of Rhoa 6 0.78 4.68 2.3
69 INT8466 Binding of Plp1 5 0.48 5.07 2.29
70 INT20991 Regulation of ITGAM 9 0.45 5.46 2.27
71 INT87323 Binding of ITGB2 16 0.47 9.91 2.24
72 INT51461 Gene_expression of Itgb2 7 0.75 5.48 2.2
73 INT146192 Positive_regulation of Positive_regulation of Rhoa 8 0.60 8.15 2.17
74 INT67332 Negative_regulation of ITGA4 8 0.51 7.95 2.14
75 INT50676 Regulation of ITGA4 2 0.07 0.6 2.13
76 INT278340 Gene_expression of Syk 7 0.51 4.92 2.09
77 INT204139 Positive_regulation of Gene_expression of BCAR1 1 0.23 0.9 1.96
78 INT61262 Negative_regulation of Positive_regulation of Itgam 5 0.57 4.25 1.95
79 INT69181 Positive_regulation of Col3a1 10 0.33 5.54 1.91
80 INT94117 Regulation of Gene_expression of Itgam 13 0.36 5.9 1.87
81 INT83596 Gene_expression of Ptk2 6 0.76 2.22 1.84
82 INT146193 Negative_regulation of Positive_regulation of Rhoa 3 0.42 3 1.84
83 INT187246 Gene_expression of ADAMTS1 3 0.24 1.17 1.84
84 INT99416 Negative_regulation of Bcar1 1 0.34 0.64 1.84
85 INT83627 Localization of ITGAM 7 0.78 7.26 1.83
86 INT210709 Regulation of Itgam 8 0.28 9.21 1.76
87 INT20992 Regulation of ITGB2 11 0.37 9.04 1.73
88 INT168602 Negative_regulation of Itgb1 3 0.21 1.29 1.73
89 INT6598 Gene_expression of ITGA2 9 0.46 4.88 1.72
90 INT125870 Gene_expression of CD47 3 0.76 5.11 1.71
91 INT23881 Gene_expression of Bcar1 8 0.52 2.48 1.69
92 INT33393 Positive_regulation of Gene_expression of PLEK 9 0.67 7.35 1.65
93 INT116110 Positive_regulation of PTK2 20 0.66 10.53 1.64
94 INT206471 Positive_regulation of Ptk2 34 0.51 25.75 1.61
95 INT352108 Positive_regulation of ADAM11 1 0.49 35.19 1.59
96 INT12942 Regulation of ITGAL 8 0.35 3.29 1.57
97 INT130332 Gene_expression of Adam17 14 0.50 4.84 1.56
98 INT99298 Positive_regulation of ITGA3 6 0.06 2.94 1.54
99 INT49404 Binding of Itgal 11 0.36 9.16 1.53
100 INT111946 Positive_regulation of Phosphorylation of PTK2 8 0.66 11.5 1.53
101 INT146190 Negative_regulation of Localization of Rhoa 4 0.42 1.64 1.5
102 INT33133 Positive_regulation of ITGA2B 13 0.67 4.09 1.44
103 INT92685 Transcription of Ctgf 7 0.72 3.92 1.44
104 INT57973 Positive_regulation of ITGB1 5 0.67 1.23 1.44
105 INT152885 Localization of Itgam 16 0.73 7.62 1.43
106 INT168683 Localization of ITGA4 2 0.12 0.61 1.4
107 INT168685 Regulation of Localization of ITGA4 1 0.07 0.61 1.4
108 INT71847 Positive_regulation of Positive_regulation of Col3a1 2 0.33 0.61 1.39
109 INT22558 Gene_expression of COL3A1 10 0.78 7.22 1.36
110 INT56365 Regulation of Gene_expression of ITGB2 5 0.60 3.87 1.36
111 INT131115 Regulation of Phosphorylation of Ptk2 2 0.61 0.3 1.34
112 INT3404 Binding of BCAR1 10 0.33 7.97 1.33
113 INT55476 Negative_regulation of ITGA2 8 0.55 3.55 1.33
114 INT114010 Gene_expression of Itga7 3 0.75 1.69 1.32
115 INT78861 Negative_regulation of Transcription of Adam17 2 0.29 1.4 1.32
116 INT247903 Localization of ITGA1 1 0.06 5.69 1.32
117 INT279019 Gene_expression of Cd47 3 0.56 1.43 1.31
118 INT78859 Transcription of Adam17 2 0.47 1.39 1.31
119 INT80086 Regulation of Gene_expression of PLEK 5 0.60 2.79 1.29
120 INT38645 Negative_regulation of Positive_regulation of DST 3 0.29 1.05 1.29
121 INT79840 Binding of Itga2b 4 0.16 2.51 1.28
122 INT78692 Regulation of PTK2B 2 0.47 0.29 1.28
123 INT319293 Phosphorylation of Ptk2b 9 0.80 3.14 1.24
124 INT234893 Positive_regulation of Adam17 4 0.38 3.78 1.22
125 INT100909 Negative_regulation of Gene_expression of Itgb2 2 0.41 1.79 1.22
126 INT7503 Negative_regulation of Cib1 1 0.46 0 1.22
127 INT87343 Negative_regulation of Phosphorylation of PTK2 34 0.59 18.38 1.19
128 INT20397 Positive_regulation of Itgax 12 0.46 6.48 1.19
129 INT87346 Binding of PTK2 6 0.37 4.03 1.18
130 INT7505 Binding of Cib1 1 0.30 0 1.18
131 INT101027 Binding of DST 20 0.41 10.9 1.17
132 INT182168 Localization of ITGAX 3 0.73 2.71 1.17
133 INT98595 Regulation of ILK 6 0.62 3.84 1.16
134 INT6599 Binding of ITGA2 4 0.35 3.6 1.16
135 INT72599 Negative_regulation of Gene_expression of ITGA2 2 0.09 1.3 1.15
136 INT352110 Gene_expression of ADAM11 1 0.55 24.56 1.15
137 INT158565 Regulation of Ctgf 3 0.61 3.93 1.14
138 INT56492 Positive_regulation of ITGAX 2 0.49 2.95 1.14
139 INT158563 Negative_regulation of Ctgf 6 0.56 4.31 1.12
140 INT30002 Negative_regulation of Negative_regulation of PLEK 3 0.42 0.76 1.12
141 INT227925 Negative_regulation of Gene_expression of ITGB1 1 0.02 2.19 1.12
142 INT21670 Localization of Lama5 1 0.31 1.11 1.1
143 INT183820 Regulation of BCAR1 4 0.39 3.27 1.06
144 INT134859 Gene_expression of Lama5 3 0.39 4.47 1.06
145 INT70329 Positive_regulation of Positive_regulation of ITGB2 3 0.67 0 1.06
146 INT60699 Negative_regulation of Gene_expression of Itgax 5 0.39 1.94 1.05
147 INT87342 Regulation of Phosphorylation of PTK2 3 0.59 5.7 1.05
148 INT48687 Gene_expression of Plp1 7 0.54 3.51 1.03
149 INT67156 Binding of ITGA4 6 0.14 2.63 1.03
150 INT290411 Gene_expression of Ptk2b 10 0.65 3.72 1.01
151 INT105986 Positive_regulation of Transcription of Ctgf 2 0.69 2.43 1.01
152 INT71732 Negative_regulation of ITGAM 3 0.41 2 1
153 INT100911 Positive_regulation of Itgb2 1 0.51 1.62 0.99
154 INT126672 Binding of Bcar1 7 0.20 2.67 0.98
155 INT180423 Positive_regulation of Gene_expression of Rhoa 7 0.40 6.22 0.98
156 INT78014 Negative_regulation of ITGA5 1 0.01 1.71 0.98
157 INT126416 Gene_expression of Itga1 1 0.02 0.89 0.98
158 INT49406 Positive_regulation of Itgal 7 0.43 8.58 0.95
159 INT275940 Negative_regulation of Syk 3 0.39 2.08 0.95
160 INT13696 Regulation of COL3A1 2 0.45 2.97 0.95
161 INT236927 Positive_regulation of Ptk2b 9 0.67 3.41 0.94
162 INT87329 Positive_regulation of Gene_expression of Itgax 15 0.64 10.85 0.93
163 INT204136 Regulation of Gene_expression of BCAR1 2 0.21 0.62 0.93
164 INT81723 Regulation of Gene_expression of ITGAL 2 0.32 0.2 0.92
165 INT120485 Positive_regulation of Plp1 1 0.33 2.2 0.9
166 INT87344 Gene_expression of PTK2 90 0.78 59.03 0.87
167 INT178803 Gene_expression of Itgb2 10 0.44 5.13 0.87
168 INT204825 Negative_regulation of Plp1 3 0.33 2.96 0.87
169 INT115964 Negative_regulation of ITGAL 7 0.34 3.76 0.86
170 INT113672 Positive_regulation of Gene_expression of ITGB1 3 0.49 1.4 0.86
171 INT131113 Negative_regulation of Ptk2 3 0.58 0.17 0.85
172 INT58186 Gene_expression of ITGA1 10 0.25 3 0.84
173 INT81220 Negative_regulation of Binding of PLEK 5 0.42 2.03 0.84
174 INT146195 Positive_regulation of Localization of Rhoa 4 0.45 2.67 0.84
175 INT36881 Regulation of Positive_regulation of PLEK 2 0.44 1.77 0.84
176 INT126572 Positive_regulation of SYK 3 0.67 2.98 0.83
177 INT168532 Localization of ADAM33 1 0.66 1.03 0.83
178 INT58184 Gene_expression of Itga3 9 0.38 6.58 0.81
179 INT82803 Positive_regulation of Gene_expression of ITGA4 4 0.57 1.57 0.81
180 INT87321 Binding of ITGAX 4 0.47 3.72 0.8
181 INT115613 Regulation of Gene_expression of ITGA2B 3 0.44 1.43 0.8
182 INT231380 Negative_regulation of Phosphorylation of Rhoa 1 0.13 1.28 0.79
183 INT134207 Gene_expression of Ptk2 56 0.73 31.97 0.78
184 INT117043 Gene_expression of Itga1 4 0.37 3.3 0.77
185 INT18413 Positive_regulation of Binding of PLEK 3 0.49 1.06 0.77
186 INT3368 Positive_regulation of Localization of PLEK 3 0.45 0.51 0.77
187 INT108044 Phosphorylation of Syk 3 0.25 1.39 0.77
188 INT87341 Regulation of Gene_expression of PTK2 2 0.62 8.34 0.77
189 INT186135 Negative_regulation of Binding of ITGAL 5 0.34 3.27 0.74
190 INT231685 Binding of CD47 12 0.47 1.55 0.73
191 INT231369 Phosphorylation of Rhoa 1 0.25 1.22 0.73
192 INT265171 Phosphorylation of Cib1 1 0.01 0.08 0.72
193 INT100910 Regulation of Positive_regulation of Itgb2 1 0.20 0.53 0.72
194 INT33733 Binding of ITGA2B 12 0.36 3.86 0.71
195 INT82808 Positive_regulation of ITGA4 7 0.44 5.19 0.71
196 INT51459 Positive_regulation of Gene_expression of Itgb2 2 0.37 1.92 0.7
197 INT104305 Binding of COL3A1 2 0.35 3.45 0.68
198 INT137204 Localization of Itgax 6 0.70 3.86 0.67
199 INT125709 Positive_regulation of Gene_expression of Col3a1 7 0.27 5.17 0.65
200 INT22556 Positive_regulation of Gene_expression of COL3A1 5 0.37 4.25 0.64
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