GO:0007243

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Name intracellular protein kinase cascade
Categary Process
Go Slim No
Go Link GO:0007243
Unique Molecular Interactions 1944
Total Molecular Interactions 2553
Total Single Events 22185
Pain Genes Associated 97

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for intracellular protein kinase cascade. They are ordered first by their pain relevance and then by number of times they were reported for intracellular protein kinase cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
3 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78
4 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
5 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
6 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71
7 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
8 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
9 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
10 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
11 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3
12 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
13 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
14 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
15 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 0.04 0.64 2.07
16 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05
17 INT110525 Binding of MC1R and OCA2 1 0.41 1.08 1.97
18 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
19 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 0.34 0.85 1.84
20 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
21 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
22 INT207630 Binding of Calm3 and Nrgn 1 0.06 1.03 1.82
23 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
24 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
25 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
26 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
27 INT314214 Mapk14 Positive_regulation of Ngf 1 0.43 1.97 1.56
28 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
29 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
30 INT145072 ASIP Negative_regulation of MC1R 1 0.29 0 1.52
31 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47
32 INT136843 Binding of Camk2a and Nrgn 1 0.47 0 1.47
33 INT139768 Binding of TRPV1 and ICK 1 0.41 1.59 1.42
34 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
35 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
36 INT139767 ICK Regulation of TRPV1 1 0.30 1.59 1.42
37 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
38 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
39 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
40 INT314213 Mapk14 Positive_regulation of Agtrap 1 0.04 1.15 1.34
41 INT300864 Ngf Positive_regulation of Mapk14 2 0.60 1.38 1.32
42 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
43 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
44 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
45 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
46 INT276282 Binding of Atrn and Mc1r 1 0.32 0.41 1.29
47 INT154203 Binding of Pick1 and Grm7 1 0.41 1.64 1.28
48 INT314209 Ngf Positive_regulation of Binding of Mapk14 1 0.43 1.48 1.27
49 INT71109 Binding of INSRR and MC1R 1 0.01 0 1.27
50 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
51 INT87026 ZAK Positive_regulation of Gene_expression of IL12A 3 0.12 2.55 1.26
52 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
53 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
54 INT118784 Thop1 Positive_regulation of Protein_catabolism of Pax3 1 0.07 0.07 1.25
55 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
56 INT314198 Mapk14 Positive_regulation of Gene_expression of Trpv1 1 0.48 1.09 1.24
57 INT314212 Mapk14 Positive_regulation of Gene_expression of Agtrap 1 0.06 1.09 1.24
58 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
59 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
60 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
61 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21
62 INT140238 HELQ Regulation of MC1R 1 0.01 0.5 1.2
63 INT328742 Il1 Positive_regulation of Mapk14 1 0.01 1.4 1.2
64 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
65 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
66 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
67 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
68 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
69 INT62382 Binding of IGHG3 and SMPD2 1 0.02 0.37 1.17
70 INT62379 Negative_regulation of Binding of IGHG3 and SMPD2 1 0.03 0.37 1.17
71 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1.16
72 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
73 INT314206 Mapk14 Positive_regulation of Pax3 1 0.08 0.67 1.15
74 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
75 INT190771 Gene_expression of Il4 Negative_regulation of Gene_expression of Mapk14 1 0.15 1.14 1.13
76 INT190770 Il4 Negative_regulation of Gene_expression of Mapk14 1 0.20 1.14 1.13
77 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
78 INT99577 Binding of KITLG and Kit 3 0.34 2.33 1.11
79 INT108409 AGT Positive_regulation of AGTR2 2 0.31 1.49 1.11
80 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
81 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
82 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
83 INT283934 Phax Negative_regulation of Positive_regulation of Mapk14 1 0.03 2.06 1.09
84 INT296458 Binding of Gria2 and Pick1 3 0.24 1.86 1.07
85 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
86 INT331108 Mc1r Positive_regulation of Mc4r 1 0.44 1.05 1.06
87 INT292531 Il10 Negative_regulation of Positive_regulation of Mapk14 1 0.15 1.13 1.06
88 INT331107 Vmn1r71 Positive_regulation of Mc1r 1 0.05 0.5 1.05
89 INT154846 Negative_regulation of Mapk14 Negative_regulation of Positive_regulation of Trpv1 1 0.23 0.07 1.05
90 INT88875 Ifng Positive_regulation of Transcription of Nos2 1 0.02 0.27 1.03
91 INT352456 Dusp1 Negative_regulation of Mapk14 1 0.03 1.31 1.03
92 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 0.11 1.59 1.02
93 INT127997 Binding of MC1R and RHCE 2 0.28 0.41 1.02
94 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
95 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
96 INT88887 IRF6 Positive_regulation of Transcription of Nos2 1 0.21 0.27 1.02
97 INT88874 Ifng Regulation of Nos2 1 0.01 0.26 1.01
98 INT88884 IRF6 Regulation of Nos2 1 0.12 0.26 1
99 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1
100 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
101 INT88886 IRF6 Positive_regulation of Nos2 1 0.22 0.26 1
102 INT88888 Regulation of IRF6 Positive_regulation of Nos2 1 0.20 0.26 1
103 INT44143 Negative_regulation of Thop1 Negative_regulation of Protein_catabolism of Penk 1 0.46 0 0.99
104 INT143915 Src Regulation of Rbm39 1 0.03 0.18 0.99
105 INT283932 Positive_regulation of Mapk14 Regulation of Gene_expression of Trpv1 1 0.14 1.28 0.99
106 INT201614 Mc1r Regulation of Uvbi1 1 0.04 1.42 0.98
107 INT133616 Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
108 INT133614 Map2k1 Regulation of Daxx 1 0.02 0.29 0.97
109 INT133615 Regulation of Map2k1 Regulation of Fadd 1 0.04 0.29 0.97
110 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
111 INT122144 Binding of Trpv1 and Prkd1 1 0.02 0.39 0.96
112 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
113 INT308169 Negative_regulation of Mapk14 Negative_regulation of Ltp 1 0.01 0.79 0.95
114 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
115 INT146579 Hba Negative_regulation of Gene_expression of Nos2 1 0.44 1.01 0.95
116 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
117 INT102554 HGF Positive_regulation of Phosphorylation of RPS6KA1 1 0.21 0.93 0.94
118 INT72386 Egf Positive_regulation of Phosphorylation of Shc1 1 0.09 0.18 0.93
119 INT145853 Casp1 Positive_regulation of Mapk14 1 0.02 0.68 0.93
120 INT318461 Nnat Positive_regulation of Mapk14 1 0.05 0.97 0.92
121 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
122 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92
123 INT352465 Dusp1 Negative_regulation of Gene_expression of Mapk14 1 0.03 1.09 0.92
124 INT135446 Map2k1 Positive_regulation of Mapk3 1 0.54 0.25 0.91
125 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
126 INT352444 Dusp1 Negative_regulation of Phosphorylation of Mapk14 1 0.03 1.09 0.91
127 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91
128 INT13282 Fgf2 Regulation of Ngf 1 0.66 0.21 0.91
129 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
130 INT66334 Fgf2 Regulation of Fgf1 1 0.37 0.17 0.9
131 INT13280 Ngf Regulation of Fgf2 1 0.48 0.2 0.9
132 INT142128 Nrgn Regulation of Creb1 1 0.38 0.25 0.89
133 INT142129 Nrgn Regulation of Camk2a 1 0.48 0.25 0.89
134 INT108687 Nfkb1 Regulation of Positive_regulation of Nos2 1 0.50 1.28 0.88
135 INT108686 Nfkb1 Regulation of Nos2 1 0.69 1.27 0.88
136 INT314207 Ngf Negative_regulation of Phosphorylation of Mapk14 1 0.33 0.4 0.88
137 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
138 INT97738 Mdk Positive_regulation of Mapk3 1 0.08 0.66 0.87
139 INT97735 Trib3 Positive_regulation of Mapk3 1 0.05 0.66 0.87
140 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87
141 INT160412 Tat Positive_regulation of Transcription of Nos2 1 0.37 0.98 0.86
142 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
143 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86
144 INT105282 Thop1 Positive_regulation of Protein_catabolism of Pnoc 1 0.17 0.1 0.85
145 INT66333 Fgf2 Negative_regulation of Positive_regulation of Npy 1 0.20 0.17 0.85
146 INT36008 Negative_regulation of Binding of Drd2 and Prl 1 0.01 2.11 0.85
147 INT105281 Negative_regulation of Thop1 Negative_regulation of Protein_catabolism of Pnoc 1 0.16 0.09 0.84
148 INT41862 Agtr2 Regulation of Cpe 1 0.00 0 0.84
149 INT41859 Agtr2 Regulation of Cck 1 0.00 0 0.84
150 INT41860 Agtr2 Regulation of Vip 1 0.02 0 0.84
151 INT183175 Binding of FGF2 and NUDT6 1 0.07 1.07 0.84
152 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83
153 INT105280 Negative_regulation of Thop1 Negative_regulation of Positive_regulation of Pnoc 1 0.14 0.09 0.83
154 INT102931 Nos3 Positive_regulation of Nos2 1 0.43 1.63 0.83
155 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
156 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
157 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
158 INT317513 Oprm1 Regulation of Positive_regulation of Src 1 0.09 0.4 0.82
159 INT288201 Mapk14 Positive_regulation of Cish 1 0.03 0.06 0.82
160 INT317570 Oprm1 Regulation of Src 1 0.04 0.4 0.82
161 INT162071 Gene_expression of MC1R Negative_regulation of Gene_expression of TNF 1 0.41 0.34 0.82
162 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
163 INT128590 Mapk14 Regulation of Nav1 1 0.21 0.25 0.82
164 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
165 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
166 INT88885 IRF6 Positive_regulation of Gene_expression of Nos2 1 0.21 0.1 0.81
167 INT88878 Negative_regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.06 0.1 0.81
168 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
169 INT99578 Binding of CEL and Kit 1 0.04 1.07 0.81
170 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
171 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8
172 INT322397 Egfr Positive_regulation of Adarb1 1 0.00 0.08 0.8
173 INT42797 Egf Regulation of Gene_expression of Penk 1 0.21 0.07 0.8
174 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
175 INT101439 Cck Positive_regulation of Agtr2 1 0.24 0.33 0.8
176 INT168648 Positive_regulation of Cx3cr1 Positive_regulation of Phosphorylation of Mapk14 1 0.35 1.51 0.8
177 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79
178 INT168455 Sult1a1 Negative_regulation of Nos2 1 0.08 1.99 0.79
179 INT168647 Cx3cr1 Positive_regulation of Phosphorylation of Mapk14 1 0.52 1.51 0.79
180 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
181 INT168456 Arr3 Positive_regulation of Nos2 1 0.21 1.98 0.79
182 INT130286 MC1R Positive_regulation of Localization of IL10 1 0.24 0.07 0.79
183 INT132889 Nfkb1 Regulation of Gene_expression of Nos2 1 0.16 0.21 0.79
184 INT21233 Ngf Regulation of Fgf1 1 0.46 0.09 0.79
185 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
186 INT151453 Gtf3a Regulation of Kit 1 0.04 0.25 0.78
187 INT128180 Gna12 Regulation of Regulation of RHOA 1 0.00 0 0.78
188 INT196577 Negative_regulation of Mapk14 Negative_regulation of Il6 1 0.13 0.45 0.78
189 INT196574 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il6 1 0.13 0.45 0.78
190 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77
191 INT196575 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1a 1 0.04 0.44 0.77
192 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
193 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
194 INT346234 MAP2K6 Positive_regulation of MAPK14 1 0.44 1.65 0.77
195 INT124385 GRK6 Negative_regulation of MC1R 1 0.42 0.42 0.77
196 INT146780 Positive_regulation of Fgfr1 Positive_regulation of Mapk14 1 0.34 0.95 0.77
197 INT124384 ADRBK1 Negative_regulation of MC1R 1 0.40 0.42 0.77
198 INT99335 Binding of Agrp and Mc1r 1 0.30 0 0.77
199 INT334833 Binding of Drd2 and Ncs1 1 0.05 1.11 0.76
200 INT231031 Egf Positive_regulation of Sec22b 1 0.03 0.05 0.76

Single Events

The table below shows the top 100 pain related interactions that have been reported for intracellular protein kinase cascade. They are ordered first by their pain relevance and then by number of times they were reported in intracellular protein kinase cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08
2 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61
3 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07
4 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87
5 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46
6 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55
7 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51
8 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43
9 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79
10 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59
11 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53
12 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
13 INT21737 Binding of MC1R 129 0.48 45.45 56.54
14 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32
15 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15
16 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67
17 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01
18 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
19 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42
20 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65
21 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94
22 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
23 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
24 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81
25 INT13501 Binding of Drd2 65 0.48 23.76 35.6
26 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
27 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
28 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
29 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
30 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
31 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82
32 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
33 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
34 INT110020 Gene_expression of Mapk14 142 0.77 72.33 30.08
35 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
36 INT62169 Positive_regulation of MC1R 72 0.69 14.56 27.52
37 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
38 INT61953 Transcription of Nos2 101 0.72 46.64 25.49
39 INT12484 Binding of Drd2 45 0.48 15.17 24.72
40 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71
41 INT89854 Regulation of Nos2 49 0.61 42.58 24.1
42 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
43 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01
44 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
45 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
46 INT99069 Positive_regulation of Gene_expression of Mapk14 42 0.53 29.84 23.16
47 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
48 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67
49 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
50 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
51 INT49774 Binding of DRD2 48 0.48 17.42 20.73
52 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48
53 INT66281 Transcription of Nos2 81 0.71 39.49 20.37
54 INT125411 Negative_regulation of Phosphorylation of Mapk14 31 0.57 18.55 19.98
55 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
56 INT5048 Binding of Edn1 55 0.47 18.86 19.16
57 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68
58 INT84712 Regulation of MC1R 36 0.62 9.34 16.91
59 INT61949 Regulation of Nos2 74 0.58 34.08 16.7
60 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33
61 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
62 INT142464 Gene_expression of Socs3 58 0.77 52.04 15.34
63 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
64 INT96911 Positive_regulation of Phosphorylation of Mapk14 46 0.70 43.03 15.15
65 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12
66 INT9191 Localization of EDN1 94 0.81 57.01 14.78
67 INT61548 Positive_regulation of Fgf2 72 0.70 32.18 14.49
68 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
69 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
70 INT6365 Localization of Edn1 56 0.81 18.84 13.83
71 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31
72 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
73 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
74 INT13823 Gene_expression of Egf 97 0.78 39.99 12.99
75 INT97448 Negative_regulation of Mc1r 20 0.58 7.37 12.91
76 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
77 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8
78 INT110025 Positive_regulation of Positive_regulation of Mapk14 39 0.63 20.67 12.71
79 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
80 INT136537 Phosphorylation of Nrgn 8 0.82 1.27 12.41
81 INT65304 Positive_regulation of Gene_expression of MC1R 34 0.70 11.32 12.09
82 INT71030 Binding of Mc1r 39 0.48 10.27 12.02
83 INT117113 Regulation of Mapk14 28 0.45 16.71 11.99
84 INT118906 Regulation of Mapk14 21 0.44 17.95 11.63
85 INT97381 Negative_regulation of Positive_regulation of Nos2 34 0.59 16.66 11.6
86 INT48956 Negative_regulation of Positive_regulation of Nos2 34 0.46 13.15 11.15
87 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92
88 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
89 INT103923 Negative_regulation of Positive_regulation of Mapk14 23 0.53 13.95 10.64
90 INT13499 Gene_expression of Agtr2 68 0.76 35.64 10.59
91 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
92 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37
93 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
94 INT6361 Localization of Edn1 30 0.81 19.09 9.7
95 INT70850 Positive_regulation of Transcription of Nos2 30 0.70 18.95 9.68
96 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
97 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
98 INT64451 Negative_regulation of MC1R 21 0.59 4.94 9.22
99 INT68133 Localization of Fgf2 36 0.81 15.37 9.14
100 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
101 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
102 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98
103 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95
104 INT111133 Negative_regulation of Mapk3 31 0.57 10.89 8.9
105 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
106 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
107 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
108 INT22771 Positive_regulation of Egf 44 0.70 16.45 8.64
109 INT18258 Negative_regulation of Thop1 20 0.56 1.6 8.61
110 INT10237 Binding of EDN1 40 0.48 16 8.48
111 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34
112 INT142462 Positive_regulation of Gene_expression of Socs3 23 0.68 23.27 8.27
113 INT4021 Positive_regulation of PLA2G1B 35 0.70 23.27 8.2
114 INT116605 Binding of Nos2 28 0.37 16.88 8.18
115 INT92680 Gene_expression of Fgf2 59 0.77 28.11 8.12
116 INT72337 Positive_regulation of Positive_regulation of Nos2 37 0.65 17.02 8.11
117 INT84765 Positive_regulation of Mc1r 24 0.70 5.95 8.01
118 INT135443 Phosphorylation of Map2k1 11 0.80 2.44 8.01
119 INT82762 Positive_regulation of Positive_regulation of Mapk3 23 0.67 7.72 7.91
120 INT135441 Positive_regulation of Map2k1 15 0.67 6.6 7.87
121 INT159750 Negative_regulation of Gene_expression of Mapk14 15 0.40 10.88 7.81
122 INT112191 Positive_regulation of Transcription of Nos2 22 0.66 12.4 7.74
123 INT85751 Positive_regulation of Positive_regulation of Nos2 40 0.60 23.53 7.72
124 INT72372 Positive_regulation of Phosphorylation of Mapk3 30 0.67 13.6 7.69
125 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
126 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
127 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
128 INT4022 Negative_regulation of PLA2G1B 30 0.59 10.41 7.58
129 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
130 INT5381 Gene_expression of FYN 18 0.75 7.65 7.35
131 INT91609 Regulation of Gene_expression of MC1R 11 0.62 2.75 7.34
132 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27
133 INT136533 Positive_regulation of Phosphorylation of Nrgn 7 0.70 0.72 7.27
134 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
135 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
136 INT128695 Regulation of Gene_expression of Mapk14 14 0.44 11.49 7.14
137 INT145299 Negative_regulation of Jak3 25 0.48 17.66 7.13
138 INT29583 Positive_regulation of Agtr2 30 0.45 21.47 7.04
139 INT48928 Positive_regulation of Gene_expression of Mapk1 19 0.48 9.38 6.59
140 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
141 INT85632 Regulation of Mc1r 14 0.61 3.22 6.5
142 INT93137 Negative_regulation of Map2k1 17 0.42 4.51 6.49
143 INT24460 Localization of Drd2 12 0.73 2.96 6.46
144 INT13822 Localization of Egf 30 0.81 13.79 6.4
145 INT64689 Positive_regulation of Gene_expression of Fgf2 30 0.70 12.05 6.2
146 INT86772 Localization of Drd2 14 0.80 1.93 6.17
147 INT48926 Positive_regulation of Gene_expression of Mapk3 12 0.46 6.02 6.13
148 INT128587 Localization of Mapk14 15 0.81 8.41 6.1
149 INT139964 Regulation of Phosphorylation of Mapk1 12 0.58 10.04 6.1
150 INT62422 Regulation of Gene_expression of Mc1r 12 0.62 2.28 5.93
151 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
152 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
153 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74
154 INT42378 Positive_regulation of Socs3 21 0.67 15.81 5.71
155 INT69700 Transcription of MC1R 15 0.71 4.32 5.62
156 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61
157 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47
158 INT100222 Binding of Src 9 0.26 5.41 5.37
159 INT135440 Positive_regulation of Phosphorylation of Map2k1 5 0.49 1.32 5.22
160 INT176524 Binding of Mapk14 19 0.43 12.54 5.21
161 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
162 INT92679 Positive_regulation of Fgf2 13 0.69 11.43 5.18
163 INT97905 Positive_regulation of FGF2 33 0.70 26.74 5.17
164 INT8653 Protein_catabolism of Thop1 13 0.92 0.73 5.16
165 INT112190 Regulation of Negative_regulation of Nos2 8 0.62 5.83 5.09
166 INT71841 Negative_regulation of Thop1 7 0.48 0.41 5.08
167 INT73608 Localization of Nos2 21 0.75 9.58 5.05
168 INT126047 Regulation of Phosphorylation of Mapk14 7 0.60 5.05 5.03
169 INT21901 Negative_regulation of Egf 25 0.58 10.46 4.99
170 INT71974 Negative_regulation of SLC9A1 19 0.41 13.93 4.96
171 INT89844 Positive_regulation of Phosphorylation of Src 10 0.43 4.71 4.95
172 INT100220 Negative_regulation of Src 13 0.41 6.37 4.93
173 INT135727 Positive_regulation of Gene_expression of Mc1r 18 0.69 8.69 4.92
174 INT116527 Positive_regulation of Gene_expression of HMOX1 29 0.70 25.79 4.87
175 INT61950 Regulation of Positive_regulation of Nos2 17 0.43 9.01 4.87
176 INT171472 Binding of Mapk14 10 0.36 6.79 4.83
177 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
178 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
179 INT204971 Gene_expression of Pink1 42 0.77 23.95 4.75
180 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
181 INT127914 Gene_expression of AGTR2 23 0.68 26.87 4.69
182 INT98453 Positive_regulation of Src 19 0.47 7.84 4.62
183 INT78995 Negative_regulation of Agtr2 26 0.42 13.05 4.56
184 INT62424 Transcription of Mc1r 8 0.71 3.67 4.54
185 INT24619 Regulation of Thop1 11 0.44 1.24 4.5
186 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
187 INT17818 Gene_expression of Agtr2 24 0.56 12.96 4.41
188 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
189 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
190 INT103914 Phosphorylation of Egfr 35 0.82 16.98 4.31
191 INT117920 Regulation of MAPK14 14 0.38 8.75 4.31
192 INT69781 Negative_regulation of FGF2 22 0.42 17.25 4.24
193 INT89784 Regulation of Transcription of Nos2 14 0.42 8.39 4.24
194 INT110024 Negative_regulation of Gene_expression of Mapk14 19 0.42 7.83 4.21
195 INT21817 Binding of Thop1 9 0.48 0.88 4.19
196 INT65926 Positive_regulation of Gene_expression of Egf 26 0.70 12.91 4.18
197 INT117921 Positive_regulation of Positive_regulation of MAPK14 9 0.44 9.93 4.18
198 INT88278 Binding of Kit 33 0.37 24.45 4.13
199 INT68099 Positive_regulation of Agtr2 21 0.48 16.63 4.07
200 INT133244 Regulation of Positive_regulation of Mapk1 11 0.43 3.52 4.03
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