GO:0007249

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Name I-kappaB kinase/NF-kappaB cascade
Categary Process
Go Slim No
Go Link GO:0007249
Unique Molecular Interactions 233
Total Molecular Interactions 329
Total Single Events 1493
Pain Genes Associated 33

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for I-kappaB kinase/NF-kappaB cascade. They are ordered first by their pain relevance and then by number of times they were reported for I-kappaB kinase/NF-kappaB cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
2 INT63918 Binding of Cck and Ripk2 1 0.28 0 2.07
3 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
4 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
5 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
6 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
7 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03
8 INT255336 Csnk2b Regulation of Phosphorylation of Nav1 1 0.10 0 1.03
9 INT255330 Nav1 Regulation of Phosphorylation of Csnk2b 1 0.10 0 0.97
10 INT265649 TBK1 Negative_regulation of COMT 1 0.01 0.61 0.94
11 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
12 INT343909 IgG Positive_regulation of Gene_expression of TLR4 1 0.04 3.49 0.91
13 INT123492 TIAF1 Positive_regulation of Gene_expression of CCL4 1 0.00 1.45 0.81
14 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
15 INT245572 Binding of AVPR2 and SPECC1 1 0.10 0.75 0.75
16 INT195545 Rel Regulation of Gene_expression of Grm3 1 0.01 0.46 0.71
17 INT255375 AIS Regulation of Negative_regulation of Csnk2b 1 0.02 0 0.69
18 INT270763 IL1B Negative_regulation of IKBKB 1 0.04 1.13 0.66
19 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66
20 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
21 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57
22 INT255379 Csnk2b Positive_regulation of Positive_regulation of AIS 1 0.02 0 0.57
23 INT263975 NR4A3 Negative_regulation of Positive_regulation of TBK1 1 0.02 1.2 0.57
24 INT343838 EDA Positive_regulation of TLR4 1 0.11 0.87 0.51
25 INT77218 Binding of NFKBIL1 and NKIRAS2 1 0.00 0.27 0.51
26 INT285911 Binding of TLR4 and Cd14 1 0.05 1.13 0.51
27 INT120852 PRL Positive_regulation of IRF1 1 0.44 0.99 0.51
28 INT306019 Binding of Tlr4 and LY96 1 0.06 0.91 0.49
29 INT120854 IRF1 Positive_regulation of Localization of TNF 1 0.20 0.94 0.49
30 INT322264 Binding of MPZ and TLR4 1 0.18 1.68 0.47
31 INT304281 IL8 Positive_regulation of TBK1 1 0.01 2.35 0.44
32 INT255331 Csnk2b Regulation of Binding of Nav1 1 0.05 0 0.43
33 INT343844 Binding of IRF6 and LY96 1 0.01 1.03 0.4
34 INT295478 IRF6 Positive_regulation of Positive_regulation of TLR4 2 0.20 0.78 0.39
35 INT329799 Binding of CD14 and LY96 2 0.04 1.02 0.39
36 INT255374 Csnk2b Positive_regulation of AIS 1 0.02 0.09 0.39
37 INT260746 Binding of TLR4 and Ecm1 1 0.02 0.44 0.38
38 INT260747 Binding of TLR4 and Tlr2 1 0.05 0.44 0.38
39 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
40 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38
41 INT188560 Negative_regulation of Binding of IRF6 and TLR4 1 0.04 0.58 0.38
42 INT339506 Binding of Irak1 and Traf6 1 0.03 0.12 0.37
43 INT123511 TIAF1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0.6 0.37
44 INT337304 PTAFR Positive_regulation of Gene_expression of TLR4 1 0.62 1.99 0.36
45 INT306254 Binding of TLR2 and LY96 1 0.25 1.29 0.36
46 INT4382 RIPK2 Regulation of INS 1 0.12 0.58 0.36
47 INT188563 TLR4 Positive_regulation of Gene_expression of PRF1 1 0.03 0.78 0.36
48 INT343857 Binding of ABCC8 and LY96 1 0.02 0.96 0.34
49 INT183784 INS Negative_regulation of Binding of TBK1 1 0.01 1.81 0.34
50 INT183783 INS Negative_regulation of TBK1 1 0.01 1.81 0.34
51 INT4381 RIPK2 Positive_regulation of Localization of INS 1 0.13 0.53 0.34
52 INT183782 INS Negative_regulation of Gene_expression of TBK1 1 0.01 1.81 0.34
53 INT324690 Binding of Traf6 and Ticam1 2 0.07 0.23 0.33
54 INT109901 RPE Positive_regulation of Positive_regulation of MAP3K14 1 0.54 0.15 0.33
55 INT185385 Binding of TLR2 and TLR4 3 0.27 3.63 0.32
56 INT322016 Binding of IL1B and TLR4 1 0.05 0.18 0.32
57 INT203089 Binding of Il1a and Traf6 1 0.04 0.66 0.32
58 INT330389 Positive_regulation of Binding of TLR2 and TLR8 1 0.08 2.78 0.32
59 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 0.06 0.67 0.32
60 INT285564 Binding of IL1B and Ripk2 1 0.04 0.76 0.31
61 INT330387 Binding of TLR2 and TLR8 1 0.06 2.77 0.31
62 INT255322 Binding of Dpep1 and Csnk2b 1 0.01 0 0.29
63 INT337293 PTAFR Positive_regulation of Positive_regulation of TLR4 1 0.62 1.43 0.28
64 INT323710 TRAF6 Regulation of MIR146A 1 0.06 0.55 0.28
65 INT343832 Positive_regulation of EDA Positive_regulation of TLR4 1 0.11 0.43 0.27
66 INT343864 EDA Positive_regulation of Gene_expression of TLR4 1 0.11 0.44 0.25
67 INT321224 TLR4 Positive_regulation of NFKB1 1 0.04 1.02 0.25
68 INT120853 PRL Positive_regulation of Positive_regulation of IRF1 1 0.41 0.49 0.25
69 INT257776 Phosphorylation of AR Positive_regulation of Localization of TAB2 1 0.26 0.38 0.24
70 INT242875 INS Negative_regulation of Gene_expression of TLR4 1 0.11 1.41 0.24
71 INT6641 Negative_regulation of Binding of Avpr2 and Oxtr 1 0.04 0.06 0.23
72 INT6642 Binding of Avpr2 and Oxtr 1 0.03 0.06 0.23
73 INT292556 Binding of F2RL1 and TLR4 1 0.05 0.52 0.22
74 INT329530 Malt1 Positive_regulation of Positive_regulation of Nfkb1 1 0.06 0.48 0.22
75 INT343910 TLR4 Regulation of Gene_expression of Icam1 1 0.04 1.3 0.22
76 INT255329 Csnk2b Regulation of Binding of Nrcam 1 0.02 0 0.22
77 INT255316 Csnk2b Regulation of Binding of Dpep1 1 0.01 0 0.22
78 INT343849 Binding of FAS and TLR4 1 0.04 0.32 0.21
79 INT55252 Binding of CCK and RIPK2 1 0.40 0 0.2
80 INT188566 TLR4 Regulation of Gene_expression of PRF1 1 0.01 0.2 0.2
81 INT301282 Tnfsf11 Positive_regulation of Traf6 1 0.10 0.65 0.2
82 INT343837 TICAM1 Positive_regulation of IRF3 1 0.03 0.19 0.19
83 INT343831 TICAM1 Positive_regulation of Gene_expression of TLR4 1 0.11 0.19 0.19
84 INT343827 MIRLET7I Regulation of Gene_expression of TLR4 1 0.00 0.13 0.19
85 INT159795 Tnf Positive_regulation of TLR4 1 0.01 0.42 0.19
86 INT159796 Tnf Positive_regulation of Gene_expression of TLR4 1 0.02 0.42 0.19
87 INT139302 Binding of CRP and TLR4 1 0.38 1.18 0.19
88 INT337310 PTAFR Regulation of Gene_expression of TLR4 1 0.24 0.8 0.18
89 INT153347 Binding of TLR4 and Cd14 1 0.10 0.17 0.17
90 INT343852 Binding of TRAF1 and TICAM1 1 0.03 0.19 0.17
91 INT254214 Binding of Myd88 and Tirap 1 0.15 0.55 0.17
92 INT217478 Binding of Tnfrsf11a and Traf6 1 0.39 1.22 0.17
93 INT343863 Binding of IRF1 and IRF3 1 0.03 0.12 0.17
94 INT246414 TLR4 Regulation of Gene_expression of TLR3 1 0.35 1.16 0.17
95 INT343850 Binding of TRAF4 and TICAM1 1 0.03 0.19 0.17
96 INT343915 Binding of Traf1 and TICAM1 1 0.08 0.19 0.17
97 INT221908 Rb1 Positive_regulation of Transcription of TNIP2 1 0.01 0.62 0.16
98 INT188569 Binding of CD4 and TLR4 1 0.16 0.34 0.16
99 INT231765 Binding of HSPD1 and TLR4 1 0.13 1.94 0.16
100 INT329796 TICAM1 Positive_regulation of IFNA1 2 0.02 0.89 0.15
101 INT343848 Positive_regulation of TLR4 Positive_regulation of STAT1 1 0.17 0.16 0.15
102 INT231757 TLR4 Positive_regulation of Negative_regulation of HMOX1 1 0.26 1.37 0.15
103 INT296082 Binding of Rel and FOXP3 1 0.35 1.14 0.15
104 INT188694 Traf6 Positive_regulation of Positive_regulation of Irf3 1 0.08 0.2 0.15
105 INT343835 TLR4 Positive_regulation of STAT1 1 0.17 0.11 0.15
106 INT279267 Binding of RIPK2 and Positive_regulation of Gene_expression of CASP1 1 0.26 1.12 0.14
107 INT255376 Binding of Csnk2b and AIS 1 0.02 0 0.14
108 INT343828 MMRN1 Positive_regulation of TLR4 1 0.02 0.91 0.14
109 INT343833 INCENP Positive_regulation of TLR4 1 0.01 0.92 0.14
110 INT343840 Protein_catabolism of INCENP Positive_regulation of TLR4 1 0.01 0.92 0.14
111 INT285419 Positive_regulation of Binding of CD14 and TLR4 1 0.32 0.19 0.14
112 INT186357 Binding of Irf1 and Stat6 1 0.04 2.09 0.14
113 INT186372 Binding of Irf1 and Stat1 1 0.04 2.06 0.14
114 INT343920 Binding of TLR4 and Hmgb1 1 0.39 0.97 0.13
115 INT285421 Positive_regulation of Binding of TLR4 and LY96 1 0.17 0.18 0.13
116 INT342518 HSP90B1 Positive_regulation of Gene_expression of TLR4 1 0.04 0.4 0.13
117 INT69688 Tgfb1 Positive_regulation of Rel 1 0.50 0 0.12
118 INT310695 Binding of Btk and Pla2g6 1 0.18 0.16 0.12
119 INT334254 Binding of Traf6 and Gtf3a 1 0.00 0.18 0.11
120 INT139787 Negative_regulation of TNFAIP8 Positive_regulation of IKBKG 1 0.10 0.89 0.11
121 INT139783 TNFAIP8 Positive_regulation of IKBKG 1 0.12 0.88 0.11
122 INT139786 TNFAIP8 Positive_regulation of Phosphorylation of IKBKG 1 0.12 0.89 0.11
123 INT139792 TNFAIP8 Positive_regulation of Protein_catabolism of IKBKG 1 0.12 0.89 0.11
124 INT231764 TLR4 Negative_regulation of HMOX1 1 0.27 1.54 0.11
125 INT231768 Binding of HMOX1 and TLR4 1 0.23 0.95 0.11
126 INT329798 Binding of MYD88 and TICAM1 2 0.01 0.24 0.1
127 INT337308 PTAFR Regulation of TLR4 1 0.24 0.1 0.1
128 INT343862 Binding of FN1 and TLR4 1 0.05 0.89 0.1
129 INT306452 Binding of MBL2 and TLR4 1 0.38 0.37 0.1
130 INT294776 PAM Positive_regulation of TLR4 1 0.00 0.17 0.1
131 INT217470 Traf6 Positive_regulation of Ngf 1 0.36 0.52 0.1
132 INT306453 MBL2 Regulation of Binding of TLR4 1 0.48 0.37 0.1
133 INT263449 Binding of NFKBIA and TBK1 1 0.07 0.2 0.1
134 INT217477 Traf6 Positive_regulation of Binding of Nup62 1 0.32 0.47 0.09
135 INT343845 TICAM1 Positive_regulation of TIRAP 1 0.05 0.25 0.09
136 INT191757 ROS1 Positive_regulation of TBK1 1 0.00 0.6 0.08
137 INT234802 Binding of AQP2 and AVPR2 2 0.15 0.84 0.07
138 INT242880 Binding of SPI1 and TLR4 1 0.03 0.24 0.07
139 INT186361 Binding of Gast and Irf1 1 0.01 1.03 0.07
140 INT306260 TLR4 Positive_regulation of TFAM 1 0.01 0 0.07
141 INT186341 Binding of Irf1 and Irf2 1 0.02 1.04 0.07
142 INT346499 Mal Positive_regulation of TICAM1 1 0.06 0.66 0.07
143 INT250153 Binding of PRNP and IKBKG 1 0.09 2.83 0.06
144 INT346452 TLR3 Positive_regulation of TBK1 1 0.03 0.45 0.06
145 INT307223 CYLD Positive_regulation of Localization of BCL3 1 0.12 0.51 0.06
146 INT350482 Tirap Regulation of TICAM2 1 0.05 0.06 0.06
147 INT250150 Binding of IKBKG and SACM1L 1 0.00 2.78 0.06
148 INT307226 CYLD Negative_regulation of Localization of BCL3 1 0.10 0.45 0.06
149 INT346449 TICAM1 Positive_regulation of TBK1 1 0.01 0.45 0.06
150 INT346454 TICAM1 Positive_regulation of IKBKE 1 0.01 0.45 0.06
151 INT350478 Tirap Regulation of Ticam1 1 0.07 0.06 0.05
152 INT186390 Binding of TNF and Irf1 1 0.02 0.99 0.05
153 INT217471 Binding of Nup62 and Traf6 1 0.26 0 0.05
154 INT334265 Binding of Traf6 and Irak4 1 0.19 0.24 0.05
155 INT324833 Grap2 Positive_regulation of TICAM2 1 0.00 0.06 0.05
156 INT186377 Binding of Irf1 and GORASP1 1 0.12 0.87 0.05
157 INT231766 TLR4 Negative_regulation of Gene_expression of HMOX1 1 0.28 0.71 0.05
158 INT246413 TLR4 Regulation of TLR3 1 0.28 0.81 0.05
159 INT352087 Binding of ADAM11 and TLR4 1 0.05 1.09 0.04
160 INT201729 Traf6 Positive_regulation of Phosphorylation of Nfkb1 1 0.00 0.45 0.04
161 INT201766 Binding of RIPK2 and Ngfr 1 0.02 0.41 0.04
162 INT295477 Binding of TLR4 and LANCL1 1 0.01 0.16 0.04
163 INT201733 Traf6 Positive_regulation of Protein_catabolism of Nfkbib 1 0.00 0.44 0.04
164 INT339112 Binding of ERBB2 and TAB2 1 0.00 0.05 0.04
165 INT201750 Traf6 Positive_regulation of Cib1 1 0.00 0.37 0.04
166 INT200645 Binding of AKT1 and TBK1 1 0.02 0.43 0.04
167 INT231775 TLR4 Regulation of Gene_expression of HMOX1 1 0.29 0.68 0.04
168 INT352076 Binding of TLR4 and Positive_regulation of ADAM11 1 0.06 1.09 0.04
169 INT350800 Binding of TLR3 and TICAM1 1 0.01 0 0.04
170 INT201746 Traf6 Positive_regulation of Map4k4 1 0.00 0.37 0.04
171 INT186348 Irf1 Regulation of Positive_regulation of Nos2 1 0.02 0.91 0.04
172 INT231774 Gene_expression of TLR4 Positive_regulation of Gene_expression of HMOX1 1 0.30 0.68 0.04
173 INT333559 TBK1 Regulation of Phosphorylation of IRF3 1 0.17 0.35 0.04
174 INT231762 TLR4 Positive_regulation of Gene_expression of HMOX1 1 0.30 0.68 0.04
175 INT201739 Traf6 Positive_regulation of Localization of Nfkb1 1 0.00 0.45 0.04
176 INT263453 Binding of GRP and TBK1 1 0.00 0.07 0.03
177 INT133489 CREB1 Positive_regulation of Csnk2b 1 0.08 0.42 0.03
178 INT287479 PSMB10 Positive_regulation of TBK1 1 0.00 0.59 0.03
179 INT172716 Binding of BCL3 and NFKB1 1 0.06 0.15 0.03
180 INT133490 AKT1 Positive_regulation of Csnk2b 1 0.02 0.42 0.03
181 INT287480 Protein_catabolism of NFKBIB Positive_regulation of TBK1 1 0.01 0.6 0.03
182 INT133491 CREB1 Positive_regulation of Phosphorylation of Csnk2b 1 0.08 0.42 0.03
183 INT191182 Binding of IRF1 and PRPF31 1 0.06 0.09 0.03
184 INT280828 Binding of Avp and Avpr2 2 0.15 0.28 0
185 INT337300 STAT3 Regulation of TLR4 1 0.15 0 0
186 INT340176 Binding of Avpr2 and Rtcd1 1 0.00 0.13 0
187 INT318081 Binding of RPL5 and UBC 1 0.02 0.52 0
188 INT242876 Negative_regulation of Binding of SPI1 and TLR4 1 0.04 0.05 0
189 INT117419 Binding of AVPR2 and TSKU 1 0.39 0.21 0
190 INT186346 Binding of Irf8 and Irf1 1 0.05 1.25 0
191 INT343842 Binding of TRAM1 and TICAM1 1 0.01 0.12 0
192 INT337291 TLR4 Regulation of Localization of IRF6 1 0.05 0.47 0
193 INT354076 Binding of Avpr2 and Oxt 1 0.07 0.09 0
194 INT246412 Binding of TLR3 and TLR4 1 0.38 0 0
195 INT307222 CYLD Regulation of Negative_regulation of BCL3 1 0.10 0.3 0
196 INT318103 Binding of UBC and Hprt 1 0.10 0.52 0
197 INT285425 Binding of LTA and TLR4 1 0.09 0.1 0
198 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
199 INT337301 STAT3 Negative_regulation of Gene_expression of TLR4 1 0.33 0 0
200 INT348020 Binding of Traf6 and Irak2 1 0.13 0.05 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for I-kappaB kinase/NF-kappaB cascade. They are ordered first by their pain relevance and then by number of times they were reported in I-kappaB kinase/NF-kappaB cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
2 INT134651 Binding of TLR4 89 0.48 66.96 23.19
3 INT133478 Phosphorylation of Csnk2b 29 0.37 1.19 18.73
4 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
5 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
6 INT38503 Positive_regulation of Ripk2 11 0.67 2.9 7.47
7 INT12771 Positive_regulation of IKBKG 27 0.69 5.99 7.02
8 INT97797 Localization of TLR4 18 0.77 13.78 6
9 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69
10 INT97145 Positive_regulation of TBK1 14 0.12 15.32 5.43
11 INT183467 Negative_regulation of TBK1 6 0.12 9.89 5.41
12 INT145767 Negative_regulation of TLR4 18 0.43 11.03 5.25
13 INT37976 Binding of Ripk2 6 0.47 0.27 5.01
14 INT20459 Regulation of Ripk2 5 0.44 0 4.53
15 INT12772 Positive_regulation of Positive_regulation of IKBKG 9 0.69 0.84 4.12
16 INT118583 Positive_regulation of IRF1 10 0.68 3.75 3.91
17 INT186808 Transcription of TLR4 22 0.69 12.77 3.73
18 INT143159 Regulation of Gene_expression of TLR4 28 0.62 15.08 3.54
19 INT12770 Negative_regulation of Positive_regulation of IKBKG 7 0.56 0.34 3.02
20 INT92335 Gene_expression of TBK1 11 0.28 8.98 3
21 INT145768 Regulation of TLR4 19 0.45 8.31 2.96
22 INT6025 Negative_regulation of RIPK2 4 0.57 0.96 2.82
23 INT97132 Negative_regulation of Positive_regulation of TBK1 5 0.08 6.54 2.76
24 INT195531 Gene_expression of Rel 9 0.75 5.02 2.72
25 INT19421 Positive_regulation of RIPK2 6 0.49 5.63 2.72
26 INT53443 Gene_expression of IKBKG 15 0.65 7.5 2.71
27 INT61004 Negative_regulation of Regulation of Ripk2 1 0.41 0 2.68
28 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
29 INT255369 Regulation of Phosphorylation of Csnk2b 1 0.20 0 2.63
30 INT255372 Negative_regulation of Csnk2b 1 0.26 0.07 2.46
31 INT12769 Localization of IKBKG 6 0.15 1.66 2.43
32 INT183468 Localization of TBK1 6 0.32 4.35 2.36
33 INT132893 Binding of CHUK 1 0.00 0.63 2.25
34 INT37977 Negative_regulation of Ripk2 3 0.42 0.92 2.03
35 INT148456 Gene_expression of LY96 7 0.19 4.35 2.02
36 INT132892 Positive_regulation of CHUK 3 0.08 1.62 2.01
37 INT118884 Gene_expression of IRF1 5 0.66 2.71 2
38 INT118882 Positive_regulation of Gene_expression of IRF1 1 0.49 1.35 1.92
39 INT255370 Gene_expression of Csnk2b 1 0.35 0.08 1.88
40 INT133480 Positive_regulation of Phosphorylation of Csnk2b 3 0.23 1.01 1.82
41 INT37978 Localization of Ripk2 4 0.78 0.57 1.73
42 INT69675 Positive_regulation of Rel 5 0.32 1.69 1.7
43 INT55511 Positive_regulation of Binding of Ripk2 1 0.49 0.19 1.69
44 INT188584 Positive_regulation of Positive_regulation of TLR4 8 0.65 5.98 1.64
45 INT132890 Positive_regulation of Binding of CHUK 1 0.00 0.44 1.6
46 INT157769 Binding of LY96 8 0.47 2.5 1.59
47 INT132891 Gene_expression of CHUK 1 0.01 0.47 1.58
48 INT123479 Gene_expression of TIAF1 4 0.09 3.29 1.45
49 INT258048 Regulation of TBK1 4 0.05 3.81 1.44
50 INT34912 Regulation of IKBKG 5 0.08 2.41 1.42
51 INT69676 Binding of Rel 4 0.47 0.16 1.38
52 INT39144 Gene_expression of RIPK2 5 0.75 2.56 1.27
53 INT47514 Localization of Avpr2 7 0.61 4.43 1.24
54 INT298979 Gene_expression of Traf6 5 0.31 1.75 1.21
55 INT38502 Gene_expression of Ripk2 3 0.65 0.17 1.16
56 INT183790 Binding of TBK1 2 0.04 2.97 1.16
57 INT119348 Binding of IKBKG 7 0.15 4.03 1.14
58 INT135615 Positive_regulation of IKBKB 3 0.59 6.16 1.1
59 INT117435 Negative_regulation of IKBKB 3 0.37 2.67 0.97
60 INT19422 Protein_catabolism of RIPK2 2 0.86 0.62 0.97
61 INT36850 Negative_regulation of Negative_regulation of RIPK2 1 0.57 0 0.97
62 INT38426 Regulation of RIPK2 3 0.60 0.62 0.91
63 INT42076 Regulation of Negative_regulation of RIPK2 1 0.44 0.91 0.91
64 INT255360 Binding of Csnk2b 1 0.17 0.16 0.88
65 INT55512 Positive_regulation of Localization of Ripk2 1 0.67 0.09 0.85
66 INT40227 Regulation of Positive_regulation of Ripk2 1 0.44 0 0.82
67 INT263481 Regulation of Positive_regulation of TBK1 1 0.07 1.28 0.81
68 INT352771 Positive_regulation of Localization of TBK1 1 0.05 0.98 0.78
69 INT188582 Positive_regulation of Transcription of TLR4 2 0.50 4.07 0.77
70 INT37975 Negative_regulation of Binding of Ripk2 1 0.57 0 0.75
71 INT69677 Negative_regulation of Binding of Rel 2 0.41 0.17 0.71
72 INT322032 Binding of TLR8 3 0.32 2.57 0.69
73 INT255359 Regulation of Negative_regulation of Csnk2b 1 0.12 0 0.69
74 INT333595 Negative_regulation of Gene_expression of TBK1 2 0.12 0.91 0.67
75 INT186800 Positive_regulation of Binding of TLR4 2 0.47 1.31 0.67
76 INT236785 Regulation of Positive_regulation of TLR4 1 0.32 1.28 0.66
77 INT6640 Negative_regulation of Avpr2 3 0.37 1.21 0.65
78 INT186266 Gene_expression of Irf1 4 0.36 3.26 0.64
79 INT188799 Positive_regulation of Protein_catabolism of Traf6 2 0.19 1.98 0.62
80 INT91330 Regulation of Localization of IKBKG 1 0.01 0.76 0.61
81 INT91328 Regulation of Gene_expression of IKBKG 1 0.01 0.75 0.61
82 INT236786 Positive_regulation of Localization of TLR4 2 0.45 1.89 0.57
83 INT47513 Negative_regulation of Localization of Avpr2 1 0.22 0.62 0.53
84 INT140905 Localization of Rel 5 0.73 2.26 0.5
85 INT19420 Positive_regulation of Positive_regulation of RIPK2 1 0.49 0.59 0.5
86 INT284454 Binding of Tirap 4 0.26 2.07 0.49
87 INT200677 Transcription of TBK1 2 0.14 0.74 0.49
88 INT343888 Regulation of Regulation of TLR4 1 0.25 1.34 0.49
89 INT135620 Regulation of IKBKB 1 0.39 1.23 0.48
90 INT12768 Negative_regulation of Localization of IKBKG 1 0.07 0 0.48
91 INT117436 Binding of IKBKB 2 0.26 1.44 0.47
92 INT202063 Regulation of Binding of TLR4 2 0.44 2.14 0.47
93 INT263479 Positive_regulation of Transcription of TBK1 1 0.12 0.32 0.46
94 INT183470 Positive_regulation of Negative_regulation of TBK1 1 0.08 0.46 0.46
95 INT38738 Localization of RIPK2 2 0.68 0.07 0.45
96 INT188800 Protein_catabolism of Traf6 2 0.40 1.6 0.45
97 INT255362 Localization of Csnk2b 1 0.34 0.08 0.42
98 INT209891 Regulation of Gene_expression of TRAF6 2 0.22 1.4 0.41
99 INT37187 Positive_regulation of Localization of IKBKG 1 0.10 0.35 0.4
100 INT201695 Positive_regulation of TIAF1 3 0.08 2.39 0.38
101 INT141493 Negative_regulation of CHUK 2 0.07 1.15 0.38
102 INT94933 Positive_regulation of Gene_expression of Bcl10 1 0.01 1.74 0.38
103 INT109913 Positive_regulation of MAP3K14 2 0.67 0.51 0.37
104 INT69684 Negative_regulation of Rel 2 0.42 0.99 0.37
105 INT217464 Binding of Traf6 5 0.29 1.28 0.35
106 INT30049 Gene_expression of Bcl10 4 0.51 2.36 0.35
107 INT231779 Transcription of LY96 2 0.13 1.22 0.35
108 INT6637 Positive_regulation of Avpr2 2 0.10 1.02 0.34
109 INT207897 Positive_regulation of TLR8 3 0.17 2.52 0.33
110 INT203075 Positive_regulation of Traf6 1 0.16 0.67 0.32
111 INT203074 Positive_regulation of Positive_regulation of Traf6 1 0.16 0.67 0.32
112 INT140903 Negative_regulation of Localization of Rel 1 0.03 0.9 0.3
113 INT240681 Positive_regulation of AVPR2 3 0.41 0.87 0.29
114 INT255358 Regulation of Gene_expression of Csnk2b 1 0.20 0 0.29
115 INT209886 Positive_regulation of TRAF6 2 0.39 1.27 0.28
116 INT318740 Positive_regulation of Gene_expression of TIAF1 1 0.07 1.29 0.28
117 INT157768 Negative_regulation of Binding of TLR4 1 0.43 0.29 0.27
118 INT324677 Gene_expression of Tirap 3 0.47 0.21 0.26
119 INT207896 Gene_expression of TLR8 3 0.36 2.82 0.26
120 INT323753 Negative_regulation of Gene_expression of TRAF6 1 0.21 0.52 0.26
121 INT106639 Negative_regulation of Negative_regulation of AVPR2 1 0.29 1.58 0.25
122 INT146953 Negative_regulation of Positive_regulation of Rel 1 0.01 1 0.25
123 INT69686 Positive_regulation of Binding of Rel 1 0.49 0 0.24
124 INT6639 Binding of Avpr2 1 0.08 0.06 0.24
125 INT6636 Positive_regulation of Binding of Avpr2 1 0.11 0.06 0.24
126 INT30059 Regulation of Positive_regulation of IKBKG 1 0.08 0 0.24
127 INT257782 Localization of TAB2 1 0.36 0.36 0.23
128 INT210927 Positive_regulation of Traf6 4 0.32 0.99 0.22
129 INT119347 Regulation of Binding of IKBKG 1 0.18 0.28 0.22
130 INT255364 Regulation of Csnk2b 1 0.12 0 0.22
131 INT323720 Negative_regulation of TRAF6 1 0.21 0.41 0.21
132 INT254173 Transcription of Traf6 1 0.25 0.26 0.21
133 INT257783 Phosphorylation of TAB2 1 0.37 0.38 0.21
134 INT177664 Gene_expression of Avpr2 3 0.35 0.49 0.2
135 INT106638 Negative_regulation of AVPR2 2 0.39 2.05 0.2
136 INT117434 Negative_regulation of Binding of IKBKB 1 0.30 1.39 0.2
137 INT186278 Binding of Irf1 7 0.16 3.99 0.19
138 INT145832 Gene_expression of IKBKB 1 0.02 1.23 0.19
139 INT343887 Positive_regulation of Gene_expression of TRAF6 1 0.16 0.21 0.19
140 INT320068 Gene_expression of AVPR2 1 0.65 0.91 0.19
141 INT186305 Positive_regulation of Gene_expression of Irf1 2 0.17 1.24 0.18
142 INT201691 Binding of RIPK2 2 0.18 1.51 0.17
143 INT296766 Transcription of IKBKG 1 0.04 1.02 0.17
144 INT343899 Localization of IRF1 1 0.23 0.12 0.17
145 INT257835 Negative_regulation of Btk 6 0.41 2.41 0.16
146 INT221906 Transcription of TNIP2 1 0.04 0.57 0.16
147 INT227586 Negative_regulation of Gene_expression of IKBKG 1 0.21 0 0.16
148 INT221905 Regulation of Transcription of TNIP2 1 0.03 0.57 0.16
149 INT231574 Binding of TAB2 2 0.04 0.35 0.15
150 INT139795 Negative_regulation of IKBKG 2 0.21 1.14 0.15
151 INT296056 Transcription of Rel 1 0.67 1.13 0.15
152 INT240596 Negative_regulation of Gene_expression of RIPK2 1 0.06 0.91 0.15
153 INT295243 Regulation of Irf1 1 0.16 0.46 0.15
154 INT320070 Localization of AVPR2 1 0.72 1.07 0.15
155 INT136002 Positive_regulation of Gene_expression of RIPK2 1 0.67 0.52 0.15
156 INT188688 Regulation of Traf6 1 0.24 0.15 0.15
157 INT285435 Protein_catabolism of TLR4 2 0.62 0.9 0.14
158 INT246424 Negative_regulation of Transcription of TLR4 2 0.41 0.52 0.14
159 INT323747 Regulation of TRAF6 1 0.13 1.15 0.14
160 INT285441 Regulation of Localization of TLR4 2 0.38 0.15 0.12
161 INT323728 Phosphorylation of TRAF6 1 0.39 0.79 0.12
162 INT139796 Positive_regulation of Phosphorylation of IKBKG 1 0.25 0.89 0.11
163 INT139800 Positive_regulation of Protein_catabolism of IKBKG 1 0.25 0.89 0.11
164 INT139794 Negative_regulation of Phosphorylation of IKBKG 1 0.21 0.89 0.11
165 INT139802 Phosphorylation of IKBKG 1 0.41 0.88 0.11
166 INT139793 Protein_catabolism of IKBKG 1 0.50 0.88 0.11
167 INT307233 Localization of BCL3 1 0.19 0.84 0.11
168 INT139797 Negative_regulation of Protein_catabolism of IKBKG 1 0.29 0.89 0.11
169 INT231778 Localization of LY96 3 0.13 0.59 0.1
170 INT307227 Positive_regulation of Gene_expression of Rel 2 0.67 1.18 0.09
171 INT144094 Negative_regulation of Localization of Ripk2 1 0.42 0.49 0.09
172 INT53444 Positive_regulation of Gene_expression of IKBKG 1 0.42 0.56 0.09
173 INT133479 Negative_regulation of Phosphorylation of Csnk2b 1 0.14 0.61 0.09
174 INT146691 Regulation of Ptplad1 1 0.09 0.44 0.09
175 INT175210 Binding of TRAF6 2 0.17 0.73 0.08
176 INT186289 Negative_regulation of Gene_expression of Irf1 1 0.10 0.99 0.07
177 INT307236 Negative_regulation of Localization of BCL3 1 0.10 0.33 0.05
178 INT334959 Regulation of Gene_expression of TLR8 1 0.21 0.91 0.05
179 INT242899 Negative_regulation of Negative_regulation of TLR4 1 0.20 0.09 0.05
180 INT306015 Regulation of Gene_expression of LY96 1 0.05 0.3 0.05
181 INT213682 Positive_regulation of Gene_expression of TBK1 2 0.21 2.18 0.04
182 INT333622 Phosphorylation of TBK1 1 0.17 0.35 0.04
183 INT318095 Gene_expression of UBC 1 0.16 1.24 0.04
184 INT186303 Transcription of Irf1 1 0.16 0.92 0.04
185 INT355368 Regulation of Btk 1 0.01 0.39 0.04
186 INT200681 Regulation of Transcription of TBK1 1 0.03 0.42 0.04
187 INT231780 Regulation of Transcription of TLR4 1 0.19 0.62 0.04
188 INT315844 Binding of Btk 2 0.16 0.59 0.03
189 INT231781 Regulation of LY96 1 0.03 0.64 0.03
190 INT350784 Positive_regulation of TICAM1 1 0.05 0 0.03
191 INT186280 Positive_regulation of Irf1 1 0.11 0.43 0.03
192 INT334960 Positive_regulation of Gene_expression of TLR8 1 0.23 0.82 0.03
193 INT174354 Gene_expression of Avpr2 8 0.35 0.87 0
194 INT257834 Gene_expression of Btk 7 0.65 3.45 0
195 INT174351 Binding of Avpr2 3 0.09 0 0
196 INT343892 Binding of TICAM2 2 0.14 0.12 0
197 INT329818 Binding of TICAM1 2 0.07 0.12 0
198 INT269074 Gene_expression of Ptplad1 2 0.38 0.72 0
199 INT345270 Negative_regulation of Tirap 1 0.02 0.15 0
200 INT177667 Positive_regulation of Gene_expression of Avpr2 1 0.31 0.27 0
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