GO:0007252

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Name I-kappaB phosphorylation
Categary Process
Go Slim No
Go Link GO:0007252
Unique Molecular Interactions 751
Total Molecular Interactions 1153
Total Single Events 5868
Pain Genes Associated 25

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for I-kappaB phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported for I-kappaB phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
2 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
3 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
4 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
5 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
6 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
7 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
8 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
9 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
10 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
11 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
12 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
13 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
14 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
15 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
16 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
17 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
18 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
19 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
20 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
21 INT167426 Tlr4 Positive_regulation of Localization of Gpt 1 0.25 1.26 1.1
22 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
23 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
24 INT185373 IRF6 Positive_regulation of Gene_expression of TLR2 1 0.08 2.96 1.04
25 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03
26 INT145163 Tlr4 Positive_regulation of Localization of Nsfl1c 1 0.02 0.43 0.94
27 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
28 INT336017 Vip Regulation of Tlr4 1 0.22 1.23 0.93
29 INT306327 Binding of Ly96 and Tlr4 1 0.10 1.83 0.91
30 INT343909 IgG Positive_regulation of Gene_expression of TLR4 1 0.04 3.49 0.91
31 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9
32 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89
33 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
34 INT168281 Tlr4 Positive_regulation of Phosphorylation of Mapk4 1 0.06 1.05 0.89
35 INT244323 Csf2 Positive_regulation of Gene_expression of Tlr4 1 0.23 1.93 0.85
36 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83
37 INT150733 Negative_regulation of Tlr3 Negative_regulation of Positive_regulation of Il1b 1 0.48 1.34 0.83
38 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
39 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79
40 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
41 INT223753 Tlr4 Positive_regulation of Gene_expression of Il10 4 0.32 1.93 0.78
42 INT296787 Tbrs1 Positive_regulation of Gene_expression of Tlr9 1 0.06 1.37 0.78
43 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
44 INT296797 Tlr9 Regulation of Positive_regulation of TNF 1 0.03 1.37 0.77
45 INT339495 Tlr4 Positive_regulation of Eif2ak2 1 0.21 0.58 0.77
46 INT136795 Spp1 Positive_regulation of Chuk 1 0.11 1.54 0.77
47 INT296788 Tlr9 Regulation of Positive_regulation of Il1 1 0.07 1.37 0.77
48 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76
49 INT296792 Tlr9 Regulation of Gene_expression of Il6 1 0.06 1.36 0.76
50 INT284306 Tlr4 Positive_regulation of Adrb3 1 0.00 1.19 0.74
51 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73
52 INT222432 Binding of Tlr4 and Cd14 1 0.02 0.74 0.71
53 INT89936 Tlr4 Positive_regulation of Il6 3 0.49 0.95 0.7
54 INT215098 Tlr4 Positive_regulation of Localization of Il6 3 0.18 1.18 0.69
55 INT280951 Tlr4 Positive_regulation of Localization of S100a8 1 0.01 1.09 0.69
56 INT215093 Tlr4 Positive_regulation of Localization of Hmgb1 1 0.32 2.9 0.68
57 INT306020 Binding of LBP and Tlr4 1 0.13 0.34 0.66
58 INT120144 Negative_regulation of Tlr4 Positive_regulation of Tnf 1 0.18 0.91 0.66
59 INT270763 IL1B Negative_regulation of IKBKB 1 0.04 1.13 0.66
60 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66
61 INT296790 Tlr9 Regulation of Bax 1 0.14 0.76 0.65
62 INT296785 Tlr9 Regulation of Bcl2 1 0.19 0.76 0.65
63 INT244320 Tlr4 Positive_regulation of Aliq1 3 0.04 4.51 0.64
64 INT339393 Tlr4 Positive_regulation of Nfkb1 1 0.24 2.06 0.61
65 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6
66 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
67 INT276603 Il10 Positive_regulation of Gene_expression of Tlr4 1 0.12 0.49 0.6
68 INT140264 Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
69 INT140263 Negative_regulation of Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
70 INT275552 Tlr4 Positive_regulation of Gene_expression of Il1 1 0.00 1.28 0.59
71 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57
72 INT162789 Binding of TLR2 and NOD2 1 0.37 0.51 0.57
73 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
74 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57
75 INT306330 Cd14 Positive_regulation of Gene_expression of Tlr4 1 0.48 0.54 0.57
76 INT146871 Tlr4 Positive_regulation of Gene_expression of ROS1 2 0.00 1.16 0.56
77 INT81303 Tlr4 Positive_regulation of Gene_expression of Hmox1 1 0.03 0.55 0.56
78 INT183695 Binding of Tlr3 and Ducm1 1 0.04 2.75 0.56
79 INT94745 Tlr4 Positive_regulation of Transcription of Il1b 1 0.15 0.48 0.56
80 INT175323 Tlr4 Positive_regulation of Gene_expression of TLR2 1 0.02 0.31 0.56
81 INT120143 Tlr4 Negative_regulation of Gene_expression of Tnf 1 0.18 0.76 0.55
82 INT243056 Binding of LBP and Tlr4 1 0.00 1.11 0.55
83 INT310767 Tlr4 Regulation of Gene_expression of S100a8 1 0.02 0.7 0.54
84 INT210934 Gene_expression of Tlr4 Negative_regulation of Ccl2 1 0.47 0.69 0.54
85 INT354367 Binding of FGFR1 and Tlr4 1 0.01 1.23 0.53
86 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52
87 INT179503 Cd14 Regulation of Positive_regulation of Tlr4 1 0.38 0.58 0.52
88 INT343838 EDA Positive_regulation of TLR4 1 0.11 0.87 0.51
89 INT285911 Binding of TLR4 and Cd14 1 0.05 1.13 0.51
90 INT324523 Tlr4 Regulation of Gene_expression of PGE 1 0.23 1.98 0.51
91 INT179507 Tlr4 Positive_regulation of Tlr2 2 0.17 1.07 0.49
92 INT306019 Binding of Tlr4 and LY96 1 0.06 0.91 0.49
93 INT254119 Binding of Bcl2a1a and Tlr4 1 0.01 1.34 0.49
94 INT158599 Tlr3 Positive_regulation of Binding of Fas 1 0.55 0.86 0.48
95 INT209046 Slc11a1 Positive_regulation of Regulation of Tlr4 1 0.07 0.09 0.48
96 INT244319 Csf2 Positive_regulation of Positive_regulation of Tlr4 1 0.23 1.03 0.48
97 INT322264 Binding of MPZ and TLR4 1 0.18 1.68 0.47
98 INT233527 Tlr4 Positive_regulation of ADORA1 1 0.00 0.45 0.47
99 INT233503 Tlr4 Positive_regulation of Adora2b 1 0.06 0.45 0.47
100 INT284300 Tlr4 Positive_regulation of Gene_expression of Mir155 1 0.18 0.91 0.47
101 INT246938 Binding of Tlr4 and Tlr2 3 0.39 2.88 0.46
102 INT207141 Tlr4 Positive_regulation of Positive_regulation of Pawr 1 0.05 0.79 0.46
103 INT233508 Tlr4 Regulation of Gene_expression of Gpr18 1 0.04 0.45 0.46
104 INT310769 Pam Regulation of Tlr4 1 0.01 0.69 0.46
105 INT296795 Binding of Tlr9 and Tlr3 2 0.22 1.29 0.45
106 INT329794 TLR2 Positive_regulation of Positive_regulation of IL12A 1 0.01 1.05 0.44
107 INT69163 Tlr4 Positive_regulation of Ptgs1 1 0.02 0.08 0.44
108 INT230461 Binding of TLR1 and TLR2 3 0.33 2.06 0.43
109 INT212810 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.03 0.74 0.43
110 INT247599 Tlr4 Positive_regulation of Gene_expression of App 1 0.17 0.39 0.42
111 INT308696 Binding of Tlr4 and Tlr4 1 0.00 0.34 0.42
112 INT185381 TNF Regulation of TLR2 2 0.31 1.9 0.41
113 INT336926 Mir341 Regulation of Tlr4 1 0.02 1.57 0.41
114 INT329803 TLR2 Positive_regulation of Positive_regulation of IL6 1 0.01 0.94 0.41
115 INT329800 TLR2 Positive_regulation of Positive_regulation of IL8 1 0.01 0.99 0.41
116 INT348790 Binding of MYD88 and Tlr4 1 0.35 1.84 0.4
117 INT238384 Tlr4 Positive_regulation of Prkca 1 0.06 0.81 0.4
118 INT295478 IRF6 Positive_regulation of Positive_regulation of TLR4 2 0.20 0.78 0.39
119 INT222418 Tlr4 Positive_regulation of Gene_expression of Il1a 1 0.00 0.31 0.39
120 INT152238 Mapk14 Positive_regulation of Localization of Tlr4 1 0.29 0.13 0.39
121 INT152237 Mapk1 Positive_regulation of Localization of Tlr4 1 0.33 0.13 0.39
122 INT81300 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.02 0.38 0.39
123 INT260744 Binding of Ecm1 and Tlr2 1 0.00 0.45 0.39
124 INT310697 Tlr4 Positive_regulation of Gene_expression of Ptger2 2 0.03 1.34 0.38
125 INT339504 Binding of Irak1 and Tlr4 1 0.08 0.12 0.38
126 INT204893 Regulation of Tlr4 Positive_regulation of gr 1 0.11 0.9 0.38
127 INT260746 Binding of TLR4 and Ecm1 1 0.02 0.44 0.38
128 INT147969 Binding of Ly86 and Tlr4 1 0.30 0.37 0.38
129 INT260747 Binding of TLR4 and Tlr2 1 0.05 0.44 0.38
130 INT215275 Tlr4 Positive_regulation of Gene_expression of Ros1 1 0.01 1.37 0.38
131 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
132 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38
133 INT188560 Negative_regulation of Binding of IRF6 and TLR4 1 0.04 0.58 0.38
134 INT204905 Tlr4 Positive_regulation of gr 1 0.18 0.9 0.38
135 INT324821 Tlr4 Positive_regulation of Gene_expression of Maob 1 0.07 0.44 0.37
136 INT324813 Tlr4 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
137 INT100091 Tlr4 Regulation of Localization of Tnf 1 0.01 0.42 0.37
138 INT324823 Tlr4 Positive_regulation of Gene_expression of Hmgb1 1 0.21 0.51 0.37
139 INT324818 Hmgb1 Positive_regulation of Gene_expression of Tlr4 1 0.21 0.51 0.37
140 INT178218 IFNA1 Regulation of Tlr7 1 0.04 0.87 0.37
141 INT110135 Tlr4 Regulation of Localization of Gnrh1 1 0.01 0.2 0.36
142 INT324808 Tlr4 Positive_regulation of Bad 1 0.02 0.43 0.36
143 INT337304 PTAFR Positive_regulation of Gene_expression of TLR4 1 0.62 1.99 0.36
144 INT306254 Binding of TLR2 and LY96 1 0.25 1.29 0.36
145 INT188563 TLR4 Positive_regulation of Gene_expression of PRF1 1 0.03 0.78 0.36
146 INT185379 Binding of IRF6 and TLR2 4 0.08 2.88 0.35
147 INT174699 Binding of Tlr2 and Tlr3 3 0.14 0.66 0.35
148 INT118743 Tlr4 Positive_regulation of Itgam 1 0.39 0.41 0.35
149 INT110132 Tlr4 Regulation of Localization of LH 1 0.01 0.2 0.35
150 INT310765 Binding of Pam and Tlr2 1 0.01 0.57 0.35
151 INT244324 Csf2 Positive_regulation of Tlr4 1 0.23 0.95 0.34
152 INT288200 Tlr2 Positive_regulation of Pik3r1 1 0.05 0.24 0.33
153 INT110134 Tlr4 Regulation of Regulation of Gnrh1 1 0.01 0.15 0.33
154 INT224691 Positive_regulation of Tlr4 Positive_regulation of Gene_expression of Il15 1 0.01 0.66 0.33
155 INT224681 Tlr2 Positive_regulation of Gene_expression of Il15 1 0.01 0.66 0.33
156 INT185385 Binding of TLR2 and TLR4 3 0.27 3.63 0.32
157 INT330377 Positive_regulation of Binding of TLR2 and TLR9 1 0.09 2.79 0.32
158 INT253766 Binding of Apex1 and Tlr4 1 0.03 0.53 0.32
159 INT330381 Binding of TLR2 and TLR9 1 0.07 2.77 0.32
160 INT295198 Tlr4 Positive_regulation of Gene_expression of Ptger2 1 0.01 0.15 0.32
161 INT322016 Binding of IL1B and TLR4 1 0.05 0.18 0.32
162 INT222441 Tlr4 Positive_regulation of Gene_expression of Tac1 1 0.00 0.39 0.32
163 INT137160 TLR7 Positive_regulation of Gene_expression of CXCR3 1 0.35 0.34 0.32
164 INT330389 Positive_regulation of Binding of TLR2 and TLR8 1 0.08 2.78 0.32
165 INT276604 Tlr4 Positive_regulation of Gene_expression of Paf 1 0.22 0.37 0.31
166 INT276605 Tlr4 Positive_regulation of Gene_expression of Mthfd1 1 0.06 0.37 0.31
167 INT288198 Binding of Tlr4 and Mapk14 1 0.01 0.63 0.31
168 INT185319 Il6 Positive_regulation of Gene_expression of Tlr4 1 0.11 0.36 0.31
169 INT185322 TNF Positive_regulation of Gene_expression of Tlr4 1 0.01 0.36 0.31
170 INT330383 Binding of TLR2 and TLR3 1 0.07 2.77 0.31
171 INT165921 Tlr4 Positive_regulation of Akt1 1 0.16 0.75 0.31
172 INT330378 Positive_regulation of Binding of TLR2 and TLR3 1 0.10 2.78 0.31
173 INT330387 Binding of TLR2 and TLR8 1 0.06 2.77 0.31
174 INT165920 Negative_regulation of Tlr4 Positive_regulation of Akt1 1 0.13 0.75 0.31
175 INT306323 Tlr4 Positive_regulation of Ticam1 3 0.25 0.55 0.3
176 INT324832 Tlr4 Positive_regulation of IFNA1 1 0.05 0.46 0.3
177 INT229600 Tlr4 Positive_regulation of Il1a 1 0.00 0.41 0.3
178 INT223752 Tlr4 Positive_regulation of Il1 1 0.12 0.64 0.3
179 INT178342 Positive_regulation of Tlr4 Positive_regulation of Il6 1 0.13 0.25 0.3
180 INT306319 Cd14 Positive_regulation of Tlr4 1 0.48 0.29 0.3
181 INT168616 Tlr4 Negative_regulation of Localization of Tnf 1 0.33 0.44 0.3
182 INT137159 Binding of TLR7 and TLR9 1 0.27 0.33 0.29
183 INT137163 Binding of TLR5 and TLR9 1 0.25 0.33 0.29
184 INT137169 Binding of TLR5 and TLR7 1 0.25 0.33 0.29
185 INT254206 Il10 Negative_regulation of Chuk 1 0.05 0.59 0.29
186 INT351770 Binding of Il6 and Ikbkb 1 0.10 1.06 0.29
187 INT354368 FGFR1 Positive_regulation of Tlr4 1 0.01 0.16 0.29
188 INT254208 Il10 Negative_regulation of Regulation of Chuk 1 0.05 0.59 0.29
189 INT144862 Tlr4 Positive_regulation of PGE 2 0.13 0.35 0.28
190 INT215274 Tlr4 Positive_regulation of Ros1 2 0.02 1.48 0.28
191 INT324801 Positive_regulation of Binding of Chuk and Irak1 1 0.03 0.86 0.28
192 INT310696 Tlr4 Positive_regulation of Positive_regulation of Cftr 1 0.16 0.74 0.28
193 INT324825 Binding of Chuk and Myd88 1 0.03 0.86 0.28
194 INT324810 Binding of Chuk and Irak1 1 0.02 0.85 0.28
195 INT337293 PTAFR Positive_regulation of Positive_regulation of TLR4 1 0.62 1.43 0.28
196 INT339494 Eif2ak2 Positive_regulation of Tlr4 1 0.13 0.18 0.28
197 INT324806 Positive_regulation of Binding of Chuk and Myd88 1 0.04 0.86 0.28
198 INT193479 TLR2 Regulation of Binding of IRF6 1 0.04 0.75 0.28
199 INT310255 Tlr4 Positive_regulation of Gene_expression of Cd86 2 0.18 0.06 0.27
200 INT276953 Positive_regulation of Tlr2 Positive_regulation of Phosphorylation of Stat3 1 0.38 0.93 0.27

Single Events

The table below shows the top 100 pain related interactions that have been reported for I-kappaB phosphorylation. They are ordered first by their pain relevance and then by number of times they were reported in I-kappaB phosphorylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
2 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
3 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
4 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17
5 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
6 INT56809 Binding of Tlr4 184 0.48 106.02 31.18
7 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19
8 INT134651 Binding of TLR4 89 0.48 66.96 23.19
9 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26
10 INT78057 Localization of Tlr4 140 0.77 67.75 21.72
11 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37
12 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
13 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49
14 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6
15 INT151120 Negative_regulation of Tlr4 18 0.59 21.09 14.46
16 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62
17 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
18 INT149985 Gene_expression of Tlr9 32 0.75 29.83 11.86
19 INT118742 Positive_regulation of Tlr4 32 0.69 27.55 11.09
20 INT133030 Positive_regulation of Gene_expression of TLR2 53 0.65 38.15 10.65
21 INT150540 Binding of TLR2 50 0.45 35.86 10.43
22 INT182137 Gene_expression of TLR9 137 0.78 48.48 9.05
23 INT146991 Positive_regulation of Gene_expression of Tlr4 21 0.69 20.76 8.69
24 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41
25 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14
26 INT295467 Negative_regulation of Gene_expression of Tlr4 11 0.58 7.94 6.83
27 INT142596 Positive_regulation of Gene_expression of Tlr2 42 0.69 38.41 6.67
28 INT207892 Binding of Tlr9 35 0.46 26.66 6.61
29 INT137206 Positive_regulation of TLR2 47 0.65 33.36 6.4
30 INT97797 Localization of TLR4 18 0.77 13.78 6
31 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95
32 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69
33 INT113700 Positive_regulation of Chuk 30 0.41 21.17 5.69
34 INT168279 Regulation of Tlr4 17 0.54 8.97 5.5
35 INT142595 Negative_regulation of Tlr2 24 0.52 19.17 5.43
36 INT174688 Binding of Tlr2 45 0.42 36.65 5.25
37 INT145767 Negative_regulation of TLR4 18 0.43 11.03 5.25
38 INT145756 Gene_expression of Tlr2 23 0.74 20.77 5.18
39 INT157622 Positive_regulation of Localization of Tlr4 34 0.48 22.63 5.09
40 INT185398 Negative_regulation of Gene_expression of TLR2 34 0.55 27.21 4.73
41 INT183681 Positive_regulation of Tlr3 20 0.62 16.25 4.54
42 INT188672 Positive_regulation of Tlr9 15 0.67 13.1 4.48
43 INT137178 Gene_expression of TLR3 46 0.72 24.97 4.33
44 INT149986 Positive_regulation of Gene_expression of Tlr9 5 0.67 8.18 4.15
45 INT158595 Gene_expression of Tlr3 25 0.69 12.09 4.07
46 INT204529 Positive_regulation of TLR9 18 0.62 15.62 3.99
47 INT117075 Negative_regulation of Ikbkb 3 0.26 9.51 3.91
48 INT186808 Transcription of TLR4 22 0.69 12.77 3.73
49 INT158596 Binding of Tlr3 24 0.47 11.66 3.69
50 INT143159 Regulation of Gene_expression of TLR4 28 0.62 15.08 3.54
51 INT264970 Positive_regulation of Localization of TLR2 1 0.11 4.21 3.37
52 INT178711 Protein_catabolism of Tlr4 15 0.84 6.75 3.19
53 INT186805 Transcription of TLR2 12 0.63 9.66 3.04
54 INT174958 Negative_regulation of Chuk 21 0.25 8.73 2.96
55 INT145768 Regulation of TLR4 19 0.45 8.31 2.96
56 INT185315 Transcription of Tlr4 24 0.69 8.65 2.93
57 INT260424 Negative_regulation of Tlr9 8 0.41 8.19 2.92
58 INT204524 Binding of TLR9 17 0.43 11.69 2.76
59 INT222845 Gene_expression of Chuk 27 0.52 25.15 2.67
60 INT133029 Regulation of TLR2 18 0.56 11.31 2.62
61 INT186799 Localization of TLR2 5 0.68 2.51 2.58
62 INT100086 Negative_regulation of Localization of Tlr4 15 0.37 5.92 2.47
63 INT132893 Binding of CHUK 1 0.00 0.63 2.25
64 INT219180 Gene_expression of TLR7 13 0.68 9.51 2.21
65 INT204775 Regulation of Tlr2 21 0.41 13.6 2.18
66 INT132892 Positive_regulation of CHUK 3 0.08 1.62 2.01
67 INT222609 Binding of Tlr4 8 0.43 4.03 1.98
68 INT326816 Negative_regulation of Positive_regulation of Tlr4 2 0.59 3.96 1.95
69 INT248374 Binding of IKBKAP 10 0.42 10.45 1.9
70 INT188678 Binding of Tlr7 14 0.32 6.6 1.89
71 INT295469 Localization of Tlr4 3 0.75 2.22 1.88
72 INT178188 Positive_regulation of Tlr7 12 0.40 6.33 1.77
73 INT301954 Regulation of Negative_regulation of Tlr4 1 0.45 2.46 1.77
74 INT191862 Phosphorylation of Tlr4 17 0.79 6.89 1.74
75 INT228195 Negative_regulation of Gene_expression of Tlr2 14 0.40 12.17 1.74
76 INT188584 Positive_regulation of Positive_regulation of TLR4 8 0.65 5.98 1.64
77 INT21565 Binding of Ikbkb 4 0.17 1.89 1.64
78 INT132890 Positive_regulation of Binding of CHUK 1 0.00 0.44 1.6
79 INT175307 Regulation of Gene_expression of TLR2 9 0.56 7.08 1.58
80 INT132891 Gene_expression of CHUK 1 0.01 0.47 1.58
81 INT174689 Gene_expression of Tlr7 11 0.67 8.24 1.56
82 INT204530 Positive_regulation of Gene_expression of TLR9 14 0.70 6.85 1.48
83 INT174683 Transcription of Tlr2 12 0.58 5.95 1.4
84 INT68774 Positive_regulation of Ikbkb 2 0.21 0.99 1.39
85 INT186810 Positive_regulation of TLR3 13 0.65 6.37 1.37
86 INT150730 Regulation of Tlr3 2 0.45 6.51 1.37
87 INT143716 Phosphorylation of Chuk 16 0.41 5.25 1.35
88 INT219159 Positive_regulation of TLR7 8 0.55 2.37 1.32
89 INT217438 Binding of Chuk 24 0.25 7.29 1.29
90 INT221131 Localization of Tlr2 17 0.80 13.82 1.28
91 INT179497 Positive_regulation of Binding of Tlr4 12 0.50 6.49 1.27
92 INT151567 Gene_expression of Tlr9 6 0.72 3.63 1.26
93 INT222843 Positive_regulation of Map3k7 4 0.24 3.04 1.24
94 INT146914 Negative_regulation of TLR2 12 0.53 7.41 1.23
95 INT190804 Positive_regulation of Tlr2 6 0.66 3.7 1.16
96 INT150729 Negative_regulation of Tlr3 3 0.43 3.26 1.14
97 INT152225 Regulation of Positive_regulation of Tlr4 8 0.53 2.5 1.12
98 INT135615 Positive_regulation of IKBKB 3 0.59 6.16 1.1
99 INT186807 Positive_regulation of Gene_expression of TLR3 8 0.53 7.19 1.08
100 INT71370 Regulation of Ikbkb 3 0.12 1.69 1.08
101 INT288489 Transcription of Tlr3 1 0.51 3.85 1.05
102 INT118738 Transcription of Tlr4 4 0.70 1.39 1
103 INT288483 Gene_expression of Tlr3 8 0.72 4.51 0.97
104 INT117435 Negative_regulation of IKBKB 3 0.37 2.67 0.97
105 INT120599 Binding of Tlr7 2 0.27 2.16 0.96
106 INT288493 Positive_regulation of Gene_expression of Tlr2 4 0.66 4.38 0.94
107 INT145760 Binding of Tlr2 5 0.46 3.59 0.89
108 INT295466 Positive_regulation of Regulation of Tlr4 2 0.44 1.33 0.89
109 INT168278 Positive_regulation of Phosphorylation of Tlr4 1 0.48 1.05 0.88
110 INT188575 Positive_regulation of Transcription of TLR2 1 0.30 1.37 0.88
111 INT168277 Phosphorylation of Tlr4 1 0.78 1.05 0.88
112 INT208243 Positive_regulation of Phosphorylation of Tlr4 5 0.31 3.74 0.86
113 INT40520 Gene_expression of Ikbkb 3 0.30 1.51 0.86
114 INT116763 Gene_expression of IKBKAP 63 0.78 54.53 0.79
115 INT186804 Binding of TLR3 14 0.45 8.41 0.79
116 INT188582 Positive_regulation of Transcription of TLR4 2 0.50 4.07 0.77
117 INT280014 Binding of TLR7 4 0.14 3.52 0.76
118 INT288495 Gene_expression of Tlr7 3 0.50 2.83 0.76
119 INT295465 Regulation of Positive_regulation of Tlr4 2 0.39 1.28 0.75
120 INT151128 Positive_regulation of Negative_regulation of Tlr4 2 0.46 1 0.75
121 INT294787 Localization of TLR9 2 0.67 2.35 0.75
122 INT224630 Positive_regulation of Positive_regulation of Tlr2 6 0.46 4.14 0.73
123 INT254115 Negative_regulation of Phosphorylation of Tlr4 5 0.27 3.91 0.71
124 INT228188 Regulation of Gene_expression of Tlr2 5 0.45 6.96 0.71
125 INT331594 Localization of Tlr9 1 0.41 1.66 0.71
126 INT331595 Positive_regulation of Localization of Tlr9 1 0.28 1.66 0.71
127 INT111059 Regulation of Ikbkb 1 0.26 0.56 0.71
128 INT255974 Transcription of Tlr3 10 0.49 6.11 0.7
129 INT186798 Regulation of TLR3 5 0.42 3.13 0.69
130 INT161529 Regulation of Gene_expression of Tlr4 3 0.45 2.7 0.69
131 INT186801 Positive_regulation of Binding of TLR2 3 0.42 2.05 0.67
132 INT186800 Positive_regulation of Binding of TLR4 2 0.47 1.31 0.67
133 INT236785 Regulation of Positive_regulation of TLR4 1 0.32 1.28 0.66
134 INT290394 Negative_regulation of Positive_regulation of TLR2 4 0.34 2.8 0.65
135 INT351509 Positive_regulation of IKBKAP 19 0.70 29.01 0.63
136 INT296782 Phosphorylation of Tlr9 1 0.61 0.53 0.63
137 INT180531 Positive_regulation of Positive_regulation of TLR2 4 0.32 4.28 0.62
138 INT204525 Negative_regulation of Gene_expression of TLR3 2 0.54 1.8 0.61
139 INT288485 Regulation of Transcription of Tlr3 1 0.20 0.85 0.61
140 INT246423 Negative_regulation of TLR3 1 0.40 2.2 0.6
141 INT178202 Regulation of Tlr7 2 0.34 1.69 0.59
142 INT143713 Positive_regulation of Phosphorylation of Chuk 4 0.25 1.38 0.58
143 INT254177 Positive_regulation of Positive_regulation of Tlr3 3 0.41 2.06 0.58
144 INT236786 Positive_regulation of Localization of TLR4 2 0.45 1.89 0.57
145 INT37351 Negative_regulation of IKBKAP 16 0.58 9.6 0.56
146 INT204864 Negative_regulation of Negative_regulation of Tlr4 3 0.30 2.05 0.56
147 INT272887 Negative_regulation of Ikbkb 2 0.29 2.18 0.55
148 INT183685 Positive_regulation of Gene_expression of Tlr3 4 0.61 1.5 0.53
149 INT260425 Positive_regulation of Gene_expression of Tlr7 3 0.39 2.88 0.53
150 INT234597 Negative_regulation of Positive_regulation of Tlr2 2 0.30 2.25 0.52
151 INT234587 Positive_regulation of Transcription of Tlr2 3 0.36 1.84 0.51
152 INT288490 Binding of Tlr9 1 0.25 1.88 0.51
153 INT285448 Positive_regulation of Gene_expression of TLR7 4 0.61 2.58 0.5
154 INT245223 Negative_regulation of Gene_expression of TLR7 3 0.37 2.81 0.5
155 INT116553 Phosphorylation of Ikbkb 3 0.37 1.35 0.5
156 INT246926 Negative_regulation of Transcription of Tlr4 3 0.41 1.78 0.49
157 INT188677 Positive_regulation of Positive_regulation of Tlr9 2 0.29 1.22 0.49
158 INT343888 Regulation of Regulation of TLR4 1 0.25 1.34 0.49
159 INT135620 Regulation of IKBKB 1 0.39 1.23 0.48
160 INT117436 Binding of IKBKB 2 0.26 1.44 0.47
161 INT202063 Regulation of Binding of TLR4 2 0.44 2.14 0.47
162 INT202494 Regulation of Chuk 5 0.20 2.17 0.46
163 INT152229 Positive_regulation of Regulation of Tlr4 2 0.40 0.29 0.46
164 INT222850 Positive_regulation of Gene_expression of Chuk 7 0.34 4.91 0.44
165 INT325457 Negative_regulation of Binding of TLR2 1 0.04 1.3 0.43
166 INT260427 Negative_regulation of Tlr7 2 0.33 1.42 0.42
167 INT237905 Positive_regulation of Binding of Tlr3 1 0.30 0.79 0.42
168 INT178171 Localization of Tlr7 1 0.51 0.53 0.41
169 INT204533 Regulation of Gene_expression of TLR9 8 0.55 2.81 0.4
170 INT183680 Localization of Tlr3 6 0.71 1.69 0.39
171 INT185313 Regulation of Transcription of Tlr4 3 0.20 0.49 0.39
172 INT73684 Gene_expression of Erc1 2 0.65 0.39 0.39
173 INT219171 Negative_regulation of Positive_regulation of TLR9 1 0.18 1.3 0.39
174 INT219182 Negative_regulation of Positive_regulation of TLR7 1 0.24 1.3 0.39
175 INT178182 Negative_regulation of Binding of Tlr4 3 0.33 2.13 0.38
176 INT141493 Negative_regulation of CHUK 2 0.07 1.15 0.38
177 INT182134 Transcription of TLR9 2 0.72 1.21 0.37
178 INT278150 Positive_regulation of Negative_regulation of Ikbkb 1 0.22 0.81 0.37
179 INT284455 Regulation of Gene_expression of Tlr9 1 0.30 1.19 0.37
180 INT118736 Positive_regulation of Transcription of Tlr4 1 0.49 0.42 0.35
181 INT246419 Positive_regulation of Negative_regulation of TLR3 1 0.43 0.67 0.34
182 INT278148 Negative_regulation of Gene_expression of Ikbkb 1 0.19 0.64 0.34
183 INT222838 Negative_regulation of Gene_expression of Chuk 5 0.25 3.43 0.31
184 INT230494 Regulation of Binding of Tlr4 3 0.45 2.97 0.31
185 INT140380 Phosphorylation of Ikbkb 2 0.31 1.5 0.29
186 INT140381 Positive_regulation of Phosphorylation of Ikbkb 1 0.12 1.21 0.29
187 INT329061 Positive_regulation of Tlr9 1 0.47 2.05 0.29
188 INT278145 Positive_regulation of Positive_regulation of Chuk 2 0.29 1.45 0.28
189 INT288189 Negative_regulation of Negative_regulation of Tlr2 1 0.26 0.43 0.28
190 INT331590 Negative_regulation of Binding of Tlr9 1 0.24 1.52 0.28
191 INT204528 Negative_regulation of Gene_expression of TLR9 5 0.52 4.47 0.27
192 INT236357 Negative_regulation of Positive_regulation of Tlr9 2 0.33 3.1 0.27
193 INT157768 Negative_regulation of Binding of TLR4 1 0.43 0.29 0.27
194 INT278153 Regulation of Negative_regulation of Ikbkb 1 0.20 0.65 0.27
195 INT288186 Regulation of Binding of Tlr2 2 0.32 1.72 0.26
196 INT222844 Positive_regulation of Binding of Chuk 1 0.13 0.58 0.26
197 INT224614 Regulation of Positive_regulation of Tlr2 1 0.13 0.56 0.26
198 INT204866 Regulation of Localization of Tlr4 3 0.37 0.66 0.25
199 INT219175 Localization of TLR7 2 0.49 1.32 0.25
200 INT204531 Negative_regulation of TLR9 1 0.43 1.29 0.25
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