GO:0007254

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Name JNK cascade
Categary Process
Go Slim No
Go Link GO:0007254
Unique Molecular Interactions 900
Total Molecular Interactions 1114
Total Single Events 9690
Pain Genes Associated 54

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for JNK cascade. They are ordered first by their pain relevance and then by number of times they were reported for JNK cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
2 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
3 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
4 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
5 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
6 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
7 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
8 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
9 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
10 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
11 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
12 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
13 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
14 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
15 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
16 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
17 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
18 INT21570 Binding of Cck and Mapk8 1 0.06 0 1.6
19 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
20 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
21 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
22 INT140029 Ifng Positive_regulation of Gene_expression of Tnf 1 0.43 1.69 1.5
23 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
24 INT161513 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Tnf 1 0.33 0.27 1.35
25 INT130333 FUT3 Negative_regulation of Positive_regulation of Tnf 1 0.01 0.36 1.29
26 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22
27 INT314196 Ngf Positive_regulation of Tnf 1 0.50 1.98 1.18
28 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
29 INT139704 Tnf Positive_regulation of Mapk14 1 0.22 0.73 1.1
30 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
31 INT167429 Negative_regulation of Mapk8 Negative_regulation of RYBP 1 0.01 1.11 1.09
32 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09
33 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
34 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
35 INT152502 Tnf Negative_regulation of Binding of Tnfrsf1a 1 0.37 0.6 1.08
36 INT223875 Negative_regulation of Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.31 0 1.07
37 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
38 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
39 INT152504 Binding of CR1 and Tnf 1 0.00 0.49 1.04
40 INT81545 Tnf Positive_regulation of Gtf3a 2 0.03 1.41 1.02
41 INT182556 Ptger4 Positive_regulation of Ptgir 1 0.08 1.31 1.02
42 INT182567 Ptger4 Positive_regulation of Ptger1 1 0.15 1.31 1.02
43 INT129216 Negative_regulation of RYBP Positive_regulation of Tnf 1 0.01 1.24 0.98
44 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
45 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
46 INT129211 RYBP Positive_regulation of Gene_expression of Tnf 1 0.01 1.04 0.94
47 INT216736 Binding of ADORA2B and ATP6V0A1 2 0.08 0.06 0.93
48 INT155259 RUNX1 Negative_regulation of Tnf 1 0.00 1.48 0.93
49 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
50 INT256646 Tnf Positive_regulation of Positive_regulation of Nfkb1 1 0.22 1.83 0.9
51 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
52 INT142278 Slc8a1 Regulation of Tnf 1 0.14 0.07 0.89
53 INT167466 Ccdc80 Negative_regulation of Tnf 1 0.01 0.76 0.88
54 INT134311 Tnf Positive_regulation of Protein_catabolism of Nfkbia 1 0.18 0.57 0.88
55 INT116556 Olr1627 Negative_regulation of Regulation of Tnf 1 0.01 1.52 0.87
56 INT152868 Tnf Regulation of Gene_expression of Trpv1 1 0.27 0.25 0.86
57 INT196578 Ephb1 Positive_regulation of Phosphorylation of Mapk9 1 0.13 0.5 0.85
58 INT196576 Trib3 Positive_regulation of Phosphorylation of Mapk9 1 0.02 0.5 0.85
59 INT146919 Tnf Positive_regulation of Gene_expression of Ccl2 1 0.16 1.44 0.84
60 INT149626 Il1b Regulation of Gene_expression of Tnf 1 0.41 0.83 0.83
61 INT102201 Tnf Regulation of Il1b 3 0.39 2.57 0.82
62 INT126555 Binding of Ighg1 and Tnf 1 0.35 2.2 0.8
63 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79
64 INT158684 MAPK8 Positive_regulation of Gene_expression of BCL2L11 1 0.51 0.44 0.78
65 INT110518 Tnf Positive_regulation of Prkce 1 0.26 1.43 0.78
66 INT152234 Mapk8 Positive_regulation of Localization of Nfkb1 1 0.33 0.26 0.78
67 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
68 INT152869 Tnf Positive_regulation of Gene_expression of Trpv1 1 0.46 0.48 0.77
69 INT98179 Aap Positive_regulation of Mapk8 1 0.01 0.75 0.74
70 INT168420 Positive_regulation of Mapk8 Positive_regulation of Phosphorylation of Jun 1 0.30 0.88 0.74
71 INT354455 Il11 Negative_regulation of Gene_expression of Tnf 1 0.31 1.21 0.74
72 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
73 INT96301 Olr1742 Negative_regulation of Gene_expression of Tnf 1 0.14 0 0.74
74 INT150992 Sfpq Negative_regulation of Gene_expression of Tnf 1 0.03 0.69 0.72
75 INT223873 Mapk8 Regulation of Positive_regulation of Ltp 1 0.24 0 0.71
76 INT159963 Tnf Positive_regulation of Localization of Il6 1 0.12 2.32 0.71
77 INT83625 Tnf Positive_regulation of Gene_expression of Cd59 1 0.15 1.08 0.69
78 INT334395 IL1B Positive_regulation of Tnf 1 0.11 2.83 0.69
79 INT223869 Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.20 0 0.68
80 INT314199 Mapk14 Regulation of Tnf 1 0.26 0.71 0.67
81 INT316690 Binding of Myd88 and Il1 2 0.06 1.75 0.66
82 INT148139 Phosphorylation of Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.46 0.98 0.66
83 INT148138 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.64 0.98 0.66
84 INT120144 Negative_regulation of Tlr4 Positive_regulation of Tnf 1 0.18 0.91 0.66
85 INT120146 seb Positive_regulation of Gene_expression of Tnf 1 0.40 0.86 0.66
86 INT110458 Binding of Atf2 and Mapk8 1 0.35 0 0.66
87 INT330046 Mapk8 Negative_regulation of Prkcg 1 0.13 0.4 0.66
88 INT120145 seb Positive_regulation of Tnf 1 0.40 0.85 0.65
89 INT132689 Tnf Regulation of Dnajc13 1 0.01 1.27 0.65
90 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
91 INT165047 Mapk14 Positive_regulation of Gene_expression of Tnf 1 0.73 0.8 0.63
92 INT165048 Trib3 Positive_regulation of Gene_expression of Tnf 1 0.08 0.8 0.63
93 INT148137 Tnf Positive_regulation of Positive_regulation of Mapk14 1 0.46 1 0.63
94 INT100030 TNF Positive_regulation of Mapk8 1 0.12 1.57 0.63
95 INT169295 PTPLA Positive_regulation of MAPK8 1 0.10 0.15 0.63
96 INT60328 Il1b Positive_regulation of Tnf 2 0.29 1.84 0.62
97 INT9163 Tnf Regulation of Gene_expression of Glul 1 0.12 1.99 0.62
98 INT61826 Tnf Negative_regulation of Il1b 1 0.39 0.89 0.62
99 INT330101 Binding of Map3k11 and Rac1 1 0.16 2.43 0.62
100 INT158362 Tnf Positive_regulation of Steap4 1 0.55 1.6 0.61
101 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 0.19 0.37 0.61
102 INT314197 Mapk14 Positive_regulation of Positive_regulation of Tnf 1 0.48 1.16 0.61
103 INT96241 Il13 Negative_regulation of Tnf 1 0.08 0.6 0.59
104 INT168416 MIR146A Regulation of Irak1 1 0.24 0.99 0.59
105 INT56451 Ifng Positive_regulation of Tnf 1 0.00 1.92 0.59
106 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58
107 INT61827 Tnf Regulation of Lta 1 0.40 1.5 0.58
108 INT94506 Tnf Positive_regulation of Gene_expression of Avp 1 0.31 0.98 0.57
109 INT162789 Binding of TLR2 and NOD2 1 0.37 0.51 0.57
110 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
111 INT94507 Tnf Positive_regulation of Gene_expression of AVP 1 0.39 0.98 0.57
112 INT8402 Tnf Regulation of Gene_expression of Vip 1 0.02 0.38 0.56
113 INT8400 Tnf Regulation of Gene_expression of Nts 1 0.00 0.38 0.56
114 INT148922 Pdia4 Negative_regulation of Tnf 1 0.09 1.01 0.56
115 INT146112 Binding of Il1b and Tnf 1 0.32 1.19 0.56
116 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56
117 INT94499 Tnf Positive_regulation of Gene_expression of Crh 1 0.27 0.97 0.56
118 INT131316 Tnf Positive_regulation of Mpo 1 0.29 0.65 0.55
119 INT352270 Tnf Positive_regulation of GZMA 1 0.13 2.43 0.55
120 INT120143 Tlr4 Negative_regulation of Gene_expression of Tnf 1 0.18 0.76 0.55
121 INT267707 Binding of Tnf and ARID1B 2 0.20 8.2 0.54
122 INT352268 Tnf Positive_regulation of Arl6ip6 1 0.02 2.42 0.54
123 INT200913 Dio1 Positive_regulation of Mapk8 1 0.00 0 0.53
124 INT8397 Tnf Regulation of Nts 1 0.00 0.38 0.53
125 INT8398 Tnf Regulation of Vip 1 0.01 0.38 0.53
126 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
127 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
128 INT206960 Lipg Regulation of Tnf 1 0.02 0.85 0.51
129 INT342689 Ptger4 Positive_regulation of Prkaca 1 0.03 0.24 0.51
130 INT23090 Tnf Positive_regulation of Localization of Prl 1 0.18 0.15 0.5
131 INT23091 Tnf Positive_regulation of Localization of Ggh 1 0.05 0.15 0.5
132 INT23092 Tnf Positive_regulation of Prl 1 0.08 0.15 0.5
133 INT93740 Ddc Positive_regulation of Tnf 1 0.00 1.45 0.5
134 INT23089 Tnf Positive_regulation of Ggh 1 0.04 0.15 0.5
135 INT285344 Il10 Negative_regulation of Gene_expression of Tnf 1 0.15 1.91 0.49
136 INT115184 Regulation of CASP1 Positive_regulation of MAPK9 1 0.09 0 0.49
137 INT161227 Binding of Ngfr and Tnf 1 0.06 0.41 0.49
138 INT155621 Tnf Regulation of Transcription of Il1b 1 0.51 0.77 0.49
139 INT187796 Binding of Tnf and Il1 1 0.09 1.85 0.48
140 INT115183 CASP1 Positive_regulation of Positive_regulation of MAPK9 1 0.16 0 0.48
141 INT67440 Pdyn Regulation of Gene_expression of Tnf 1 0.23 0.19 0.48
142 INT162890 Negative_regulation of Binding of LEP and Tnf 1 0.03 0.49 0.48
143 INT162889 Binding of LEP and Tnf 1 0.03 0.49 0.48
144 INT115185 CASP1 Positive_regulation of MAPK9 1 0.15 0 0.48
145 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
146 INT187795 Positive_regulation of Binding of Tnf and Il1 1 0.13 1.87 0.48
147 INT137416 Binding of SDC1 and Tnf 1 0.00 1.19 0.47
148 INT125568 Binding of Casr and Ncoa6 3 0.50 1.13 0.46
149 INT314200 Positive_regulation of Binding of Nos2 and Tnf 1 0.42 0.34 0.46
150 INT254225 Mapk14 Positive_regulation of Mapk8 1 0.02 0.87 0.46
151 INT314201 Binding of Nos2 and Tnf 1 0.31 0.33 0.46
152 INT95404 Map3k1 Positive_regulation of Phosphorylation of Ephb1 1 0.12 0.16 0.46
153 INT254198 Mapk1 Positive_regulation of Mapk8 1 0.01 0.87 0.46
154 INT95408 Map3k1 Positive_regulation of Ephb1 1 0.12 0.16 0.46
155 INT161652 Gsr Regulation of Gene_expression of Tnf 1 0.17 0.98 0.46
156 INT117776 Binding of Ptk2 and Regulation of Phosphorylation of Ddr1 1 0.10 0.17 0.46
157 INT96245 Negative_regulation of Tnf Positive_regulation of KNG1 1 0.01 0.59 0.45
158 INT96246 Tnf Positive_regulation of KNG1 1 0.01 0.59 0.45
159 INT148635 Abat Negative_regulation of Gene_expression of Tnf 1 0.10 0.53 0.44
160 INT86380 Adra2a Regulation of Gene_expression of Tnf 1 0.15 0.79 0.44
161 INT278950 MAPK8 Negative_regulation of Localization of EPHB2 1 0.25 0.47 0.43
162 INT126019 Binding of Ltbr and Tnf 1 0.18 1.61 0.43
163 INT126020 Binding of fc and Tnf 1 0.22 1.61 0.43
164 INT107694 Tnf Positive_regulation of Gene_expression of Cxcl1 1 0.60 0.63 0.43
165 INT264476 Il1a Positive_regulation of Gene_expression of Mapk8 1 0.04 0 0.43
166 INT142273 KITLG Positive_regulation of Gene_expression of Tnf 1 0.07 0.9 0.43
167 INT116931 OPRK1 Regulation of MAPK8 1 0.31 0.07 0.43
168 INT264475 Il1a Positive_regulation of Mapk8 1 0.04 0 0.43
169 INT51475 Binding of Il6 and Tnf 1 0.15 0.61 0.43
170 INT126018 Binding of Lifr and Tnf 1 0.06 1.61 0.43
171 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
172 INT319312 Socs4 Positive_regulation of Mapk8 1 0.05 0.68 0.41
173 INT147977 Tnf Positive_regulation of Il4 1 0.01 1.12 0.41
174 INT165568 Tnf Regulation of Gene_expression of Il1b 1 0.41 1.26 0.41
175 INT339493 Binding of Irak1 and Irak3 1 0.02 0.17 0.41
176 INT354984 Binding of Cacna1a and Tnf 1 0.01 0.83 0.4
177 INT230500 Il1 Positive_regulation of Gene_expression of Tnf 1 0.07 1.83 0.4
178 INT134761 Ghrl Regulation of Localization of Tnf 1 0.20 0.76 0.4
179 INT154756 Tnf Positive_regulation of Nfkb1 1 0.31 0.78 0.4
180 INT168458 Sult1a1 Negative_regulation of Tnf 1 0.09 1 0.4
181 INT165565 Tnf Regulation of Gene_expression of Sdf2l1 1 0.26 1.15 0.39
182 INT165567 Tnf Regulation of Gene_expression of Tgfb1 1 0.41 1.15 0.39
183 INT216737 Binding of ADORA2B and TCFL5 1 0.03 0.05 0.39
184 INT228761 Tnf Positive_regulation of Gene_expression of Ccl17 1 0.20 0.66 0.39
185 INT165566 Tnf Regulation of Gene_expression of Il6 1 0.32 1.15 0.39
186 INT339504 Binding of Irak1 and Tlr4 1 0.08 0.12 0.38
187 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
188 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38
189 INT179938 Negative_regulation of Mapk8 Negative_regulation of TNF 1 0.02 1.09 0.37
190 INT339506 Binding of Irak1 and Traf6 1 0.03 0.12 0.37
191 INT187233 Positive_regulation of Mapk8 Positive_regulation of Jun 1 0.12 0.92 0.37
192 INT264480 Il1a Positive_regulation of Phosphorylation of Mapk8 1 0.04 0 0.37
193 INT189493 Tnf Positive_regulation of Localization of Darc 1 0.00 0.53 0.37
194 INT100091 Tlr4 Regulation of Localization of Tnf 1 0.01 0.42 0.37
195 INT88068 Ptger2 Positive_regulation of Transcription of Ptger4 1 0.15 0 0.36
196 INT309120 Edc4 Negative_regulation of Positive_regulation of Mapk8 1 0.01 1.03 0.36
197 INT138515 Drd3 Negative_regulation of Localization of Tnf 1 0.06 0.4 0.36
198 INT112619 Mapk9 Regulation of Il1b 1 0.16 1.11 0.36
199 INT112618 Pdpk1 Regulation of Tnf 1 0.03 1.11 0.36
200 INT109091 Tnf Positive_regulation of Localization of Il1b 1 0.56 1.08 0.36

Single Events

The table below shows the top 100 pain related interactions that have been reported for JNK cascade. They are ordered first by their pain relevance and then by number of times they were reported in JNK cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
2 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
3 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
4 INT10166 Localization of Tnf 237 0.81 153.95 88.64
5 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
6 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
7 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
8 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
9 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
10 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
11 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
12 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
13 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
14 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98
15 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52
16 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2
17 INT35406 Localization of Tnf 94 0.81 64.63 31.65
18 INT52801 Regulation of Gene_expression of Tnf 55 0.62 48.74 26.59
19 INT66753 Negative_regulation of Positive_regulation of Tnf 45 0.59 35.28 22.33
20 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25
21 INT53575 Regulation of Gene_expression of Tnf 46 0.62 34.35 20.63
22 INT53574 Regulation of Tnf 45 0.62 40.68 19.71
23 INT66751 Negative_regulation of Localization of Tnf 48 0.59 26 19.36
24 INT66755 Transcription of Tnf 45 0.72 37.1 19.11
25 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
26 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24
27 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86
28 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75
29 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
30 INT49986 Transcription of Tnf 25 0.72 18.3 16.22
31 INT216751 Gene_expression of ADORA2B 36 0.60 3.42 15.6
32 INT10173 Binding of Tnf 45 0.48 35.6 14.32
33 INT95738 Positive_regulation of Phosphorylation of Mapk8 40 0.70 23.46 13.88
34 INT64048 Positive_regulation of Positive_regulation of Tnf 32 0.70 21.24 13.74
35 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
36 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65
37 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44
38 INT60434 Negative_regulation of Positive_regulation of Tnf 20 0.46 10.01 10.64
39 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83
40 INT68960 Gene_expression of Ptger4 42 0.67 15.75 9.64
41 INT111998 Positive_regulation of Positive_regulation of Mapk8 23 0.69 9.33 8.97
42 INT48860 Regulation of Localization of Tnf 25 0.61 20.68 8.78
43 INT53573 Negative_regulation of Localization of Tnf 19 0.59 11.57 8.54
44 INT104481 Regulation of Mapk8 21 0.50 13.87 8.41
45 INT96912 Positive_regulation of Phosphorylation of Mapk8 29 0.69 18.33 8.14
46 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
47 INT99071 Positive_regulation of Gene_expression of Mapk8 16 0.55 9.87 7.58
48 INT68299 Binding of Tnf 17 0.39 12.55 7.49
49 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36
50 INT216752 Binding of ADORA2B 17 0.36 0.76 7.36
51 INT66752 Positive_regulation of Transcription of Tnf 15 0.68 10.86 7.26
52 INT12771 Positive_regulation of IKBKG 27 0.69 5.99 7.02
53 INT83597 Phosphorylation of Ptk2 20 0.82 3.24 5.7
54 INT6487 Positive_regulation of Positive_regulation of Tnf 21 0.56 16.06 5.64
55 INT58145 Positive_regulation of Localization of Tnf 20 0.67 13.33 5.44
56 INT128922 Negative_regulation of Gene_expression of Mapk8 6 0.34 3.93 5.36
57 INT197491 Gene_expression of Myd88 32 0.74 14.59 5.29
58 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
59 INT135291 Positive_regulation of Positive_regulation of Mapk8 24 0.64 19.37 5.16
60 INT92054 Positive_regulation of Transcription of Tnf 8 0.50 4.93 5.05
61 INT80712 Gene_expression of PTGER4 21 0.65 13.08 5.03
62 INT131717 Positive_regulation of Gene_expression of Mapk8 18 0.55 14.25 5.02
63 INT88062 Gene_expression of Ptger4 13 0.77 2.4 4.94
64 INT108919 Positive_regulation of Mapk9 9 0.34 3.55 4.74
65 INT142752 Positive_regulation of Myd88 26 0.66 12.07 4.4
66 INT88059 Positive_regulation of Ptger4 9 0.69 1.41 4.4
67 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28
68 INT109935 Positive_regulation of Phosphorylation of MAPK8 35 0.68 13.13 4.18
69 INT12772 Positive_regulation of Positive_regulation of IKBKG 9 0.69 0.84 4.12
70 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06
71 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94
72 INT66754 Negative_regulation of Transcription of Tnf 11 0.43 8.43 3.93
73 INT23088 Phosphorylation of Tnf 15 0.79 9.85 3.82
74 INT142754 Binding of Myd88 20 0.36 9.61 3.8
75 INT117773 Positive_regulation of Phosphorylation of Ptk2 9 0.69 0.89 3.71
76 INT104480 Phosphorylation of Mapk9 8 0.80 6.59 3.62
77 INT21569 Binding of Mapk8 8 0.48 5.55 3.44
78 INT109914 Positive_regulation of MAPK9 16 0.56 7.64 3.27
79 INT133086 Positive_regulation of Phosphorylation of Map2k7 1 0.05 4.34 3.27
80 INT119470 Regulation of Ptger4 6 0.43 3.94 3.24
81 INT65427 Regulation of Positive_regulation of Tnf 7 0.60 3.49 3.22
82 INT163529 Negative_regulation of Positive_regulation of Mapk8 14 0.43 8.37 3.2
83 INT38013 Gene_expression of Casr 30 0.73 6.03 3.09
84 INT74506 Localization of Casr 16 0.76 1.95 3.06
85 INT133082 Phosphorylation of Map2k7 5 0.15 4.27 3.05
86 INT12770 Negative_regulation of Positive_regulation of IKBKG 7 0.56 0.34 3.02
87 INT110755 Negative_regulation of Positive_regulation of Mapk8 15 0.46 9.91 2.98
88 INT103910 Binding of NOD2 19 0.47 12.24 2.93
89 INT95049 Negative_regulation of Regulation of Tnf 4 0.42 1.64 2.84
90 INT6025 Negative_regulation of RIPK2 4 0.57 0.96 2.82
91 INT68962 Positive_regulation of Ptger4 20 0.67 7.3 2.79
92 INT19421 Positive_regulation of RIPK2 6 0.49 5.63 2.72
93 INT162792 Gene_expression of NOD1 19 0.71 6.11 2.71
94 INT53443 Gene_expression of IKBKG 15 0.65 7.5 2.71
95 INT95735 Regulation of Phosphorylation of Mapk8 7 0.50 1.88 2.69
96 INT209889 Gene_expression of TRAF6 13 0.63 6.85 2.67
97 INT75736 Regulation of Localization of Tnf 6 0.62 4.61 2.67
98 INT95739 Negative_regulation of Phosphorylation of Mapk8 11 0.42 6.77 2.61
99 INT159121 Positive_regulation of Map3k1 10 0.45 8.79 2.6
100 INT95944 Binding of Fgf12 11 0.28 8.98 2.53
101 INT12769 Localization of IKBKG 6 0.15 1.66 2.43
102 INT121379 Positive_regulation of Casr 13 0.66 2.92 2.34
103 INT128926 Gene_expression of Map2k7 5 0.23 3.01 2.31
104 INT66804 Negative_regulation of Negative_regulation of Tnf 4 0.56 2.79 2.26
105 INT105760 Negative_regulation of Casr 5 0.58 0.93 2.17
106 INT109908 Localization of MAPK8 10 0.73 3.86 2.14
107 INT94615 Localization of Ptger4 5 0.28 0.35 2.13
108 INT156270 Regulation of Positive_regulation of Mapk8 3 0.41 2.31 2.08
109 INT152696 Negative_regulation of Negative_regulation of Mapk8 1 0.32 0.35 2
110 INT108921 Negative_regulation of Positive_regulation of Mapk9 3 0.25 1.8 1.99
111 INT109313 Binding of Mapk8 6 0.48 1.78 1.98
112 INT96916 Negative_regulation of Phosphorylation of Mapk8 16 0.52 9.68 1.97
113 INT122649 Positive_regulation of Regulation of Tnf 2 0.49 2.78 1.96
114 INT95400 Negative_regulation of Map3k1 3 0.15 0.78 1.92
115 INT208890 Gene_expression of Irak1 7 0.65 2.42 1.87
116 INT38014 Regulation of Casr 7 0.31 1.14 1.87
117 INT83596 Gene_expression of Ptk2 6 0.76 2.22 1.84
118 INT117221 Positive_regulation of Gene_expression of NOD2 7 0.65 4.39 1.83
119 INT164864 Positive_regulation of Negative_regulation of Mapk8 1 0.31 1.33 1.82
120 INT109921 Phosphorylation of MAPK9 9 0.67 5.07 1.81
121 INT104478 Positive_regulation of Mapk9 5 0.67 5.56 1.81
122 INT133084 Positive_regulation of Gene_expression of Map2k7 3 0.17 2.56 1.8
123 INT162793 Regulation of NOD2 6 0.45 7.61 1.78
124 INT77801 Negative_regulation of Binding of Tnf 5 0.42 3.93 1.77
125 INT299365 Transcription of Mapk8 9 0.72 5.91 1.75
126 INT44784 Gene_expression of NPHS1 8 0.64 9.75 1.74
127 INT216749 Positive_regulation of ADORA2B 6 0.37 0.89 1.72
128 INT104479 Negative_regulation of Mapk9 3 0.37 2.83 1.69
129 INT169786 Localization of Ptger4 7 0.69 1.82 1.65
130 INT233975 Positive_regulation of Gene_expression of Myd88 7 0.66 4.17 1.65
131 INT159957 Positive_regulation of Phosphorylation of Tnf 3 0.49 2.63 1.65
132 INT168714 Negative_regulation of Binding of Mapk8 1 0.36 0.18 1.62
133 INT206471 Positive_regulation of Ptk2 34 0.51 25.75 1.61
134 INT142678 Positive_regulation of Phosphorylation of Mapk9 4 0.51 2.1 1.6
135 INT216847 Transcription of ADORA2B 1 0.51 0.93 1.55
136 INT61967 Positive_regulation of Negative_regulation of Tnf 3 0.50 2.46 1.49
137 INT142676 Phosphorylation of Mapk9 5 0.61 1.48 1.48
138 INT157362 Negative_regulation of MAPK9 7 0.35 4.27 1.44
139 INT34912 Regulation of IKBKG 5 0.08 2.41 1.42
140 INT83659 Negative_regulation of Binding of Tnf 3 0.37 1.57 1.42
141 INT131188 Negative_regulation of Gene_expression of PTGER4 1 0.41 2.51 1.41
142 INT159784 Gene_expression of Mapk9 8 0.61 6.28 1.37
143 INT142679 Negative_regulation of Phosphorylation of Mapk9 1 0.17 0.51 1.37
144 INT90226 Gene_expression of Mapk9 3 0.65 1.94 1.34
145 INT296755 Positive_regulation of Gene_expression of PTGER4 2 0.33 2.03 1.34
146 INT131115 Regulation of Phosphorylation of Ptk2 2 0.61 0.3 1.34
147 INT129737 Positive_regulation of Casr 2 0.52 2.39 1.33
148 INT50785 Gene_expression of Map3k1 6 0.44 4.22 1.32
149 INT117219 Positive_regulation of NOD2 9 0.69 4.66 1.31
150 INT246928 Negative_regulation of Myd88 12 0.38 6.16 1.3
151 INT233970 Regulation of Myd88 7 0.45 5.2 1.28
152 INT39144 Gene_expression of RIPK2 5 0.75 2.56 1.27
153 INT125079 Negative_regulation of Gene_expression of MAPK8 9 0.39 4.87 1.25
154 INT222843 Positive_regulation of Map3k7 4 0.24 3.04 1.24
155 INT140877 Regulation of Ptger4 6 0.36 2.2 1.23
156 INT154048 Negative_regulation of Gene_expression of Mapk8 5 0.43 4.43 1.22
157 INT298979 Gene_expression of Traf6 5 0.31 1.75 1.21
158 INT88063 Binding of Ptger4 2 0.37 0.35 1.2
159 INT157364 Positive_regulation of Phosphorylation of MAPK9 3 0.56 2.33 1.15
160 INT119348 Binding of IKBKG 7 0.15 4.03 1.14
161 INT129587 Protein_catabolism of Tnf 2 0.86 1.41 1.08
162 INT168276 Negative_regulation of Phosphorylation of Tnf 1 0.19 1.3 1.08
163 INT140054 Negative_regulation of Mapk9 3 0.25 1.9 1.05
164 INT135027 Regulation of Positive_regulation of Tnf 3 0.38 2.84 1.05
165 INT193256 Positive_regulation of PTGER4 6 0.19 4.38 0.99
166 INT154227 Regulation of Gene_expression of NOD2 3 0.44 3.38 0.99
167 INT20201 Positive_regulation of Fgf12 8 0.43 15.13 0.98
168 INT19422 Protein_catabolism of RIPK2 2 0.86 0.62 0.97
169 INT36850 Negative_regulation of Negative_regulation of RIPK2 1 0.57 0 0.97
170 INT161882 Negative_regulation of Gene_expression of NPHS1 2 0.41 6.54 0.95
171 INT38426 Regulation of RIPK2 3 0.60 0.62 0.91
172 INT42076 Regulation of Negative_regulation of RIPK2 1 0.44 0.91 0.91
173 INT250171 Localization of Myd88 4 0.72 1.95 0.88
174 INT134307 Negative_regulation of Protein_catabolism of Tnf 1 0.41 0.57 0.88
175 INT254188 Positive_regulation of Irak1 7 0.44 3.46 0.87
176 INT115822 Regulation of Transcription of Tnf 3 0.35 1.96 0.87
177 INT134310 Positive_regulation of Protein_catabolism of Tnf 1 0.49 0.57 0.87
178 INT131113 Negative_regulation of Ptk2 3 0.58 0.17 0.85
179 INT196583 Regulation of Phosphorylation of Mapk9 1 0.37 0.5 0.85
180 INT200900 Localization of Mapk8 9 0.40 5.76 0.84
181 INT104482 Positive_regulation of Phosphorylation of Mapk9 2 0.49 1.55 0.84
182 INT169788 Negative_regulation of Ptger4 5 0.51 2.11 0.82
183 INT169792 Positive_regulation of Gene_expression of Ptger4 5 0.60 2 0.82
184 INT50784 Positive_regulation of Gene_expression of Map3k1 2 0.06 0.94 0.8
185 INT134207 Gene_expression of Ptk2 56 0.73 31.97 0.78
186 INT136690 Regulation of Negative_regulation of Tnf 5 0.45 3.58 0.78
187 INT102199 Regulation of Transcription of Tnf 2 0.45 2.25 0.78
188 INT182293 Binding of MAPK8 11 0.34 4.6 0.77
189 INT165104 Negative_regulation of Negative_regulation of Mapk8 5 0.43 4.21 0.77
190 INT84641 Positive_regulation of MAP2K4 5 0.13 3.41 0.77
191 INT165105 Localization of Mapk8 7 0.69 4.45 0.76
192 INT88067 Negative_regulation of Positive_regulation of Ptger4 2 0.58 0.3 0.75
193 INT77591 Binding of Ptger4 3 0.36 1.09 0.74
194 INT164489 Regulation of Gene_expression of Mapk8 2 0.44 0.65 0.74
195 INT237158 Negative_regulation of Negative_regulation of Tnf 2 0.13 1.37 0.74
196 INT131186 Negative_regulation of PTGER4 2 0.41 2.97 0.74
197 INT177940 Gene_expression of MAPK9 5 0.56 2.77 0.73
198 INT237709 Negative_regulation of Negative_regulation of MAPK8 6 0.25 2.09 0.72
199 INT104488 Negative_regulation of Phosphorylation of Mapk9 1 0.41 1.03 0.72
200 INT169790 Negative_regulation of Localization of Ptger4 1 0.37 0.77 0.72
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