GO:0007256

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Name activation of JNKK activity
Categary Process
Go Slim No
Go Link GO:0007256
Unique Molecular Interactions 41
Total Molecular Interactions 52
Total Single Events 277
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of JNKK activity. They are ordered first by their pain relevance and then by number of times they were reported for activation of JNKK activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT330101 Binding of Map3k11 and Rac1 1 0.16 2.43 0.62
2 INT95404 Map3k1 Positive_regulation of Phosphorylation of Ephb1 1 0.12 0.16 0.46
3 INT95408 Map3k1 Positive_regulation of Ephb1 1 0.12 0.16 0.46
4 INT354704 Binding of MAP3K1 and Pick1 1 0.00 0.76 0.41
5 INT255934 Tauph Positive_regulation of Map3k1 1 0.00 0.1 0.32
6 INT255946 MAPK14 Positive_regulation of Map3k1 1 0.04 0.1 0.32
7 INT330100 Binding of Sh3rf1 and Map3k11 1 0.08 1.21 0.31
8 INT274932 Binding of Insrr and Map3k1 1 0.00 0 0.28
9 INT274947 Binding of Map3k1 and Grip1 1 0.00 0 0.27
10 INT274080 Binding of ARHGAP4 and Map3k5 1 0.41 1.92 0.2
11 INT177916 PRKG1 Positive_regulation of Positive_regulation of MAP3K1 1 0.05 1.07 0.14
12 INT280488 Bdnf Positive_regulation of Gene_expression of Map3k1 1 0.01 1.49 0.11
13 INT92389 ALK Positive_regulation of Gene_expression of Map3k1 1 0.01 1.14 0.09
14 INT232559 Map3k1 Positive_regulation of Esr1 1 0.19 0.26 0.09
15 INT227836 Binding of ERCC6 and GPER 1 0.21 0.27 0.08
16 INT297964 Binding of CDK8 and MAP3K11 1 0.26 0.29 0.07
17 INT297969 Positive_regulation of Binding of CDK8 and MAP3K11 1 0.35 0.29 0.07
18 INT250025 Map3k1 Positive_regulation of Regulation of Bcl2 1 0.01 1.1 0.04
19 INT189375 Rpa1 Regulation of ERCC6 1 0.04 0.05 0
20 INT227830 CSH1 Regulation of ERCC6 1 0.11 0 0
21 INT215413 ITC1 Negative_regulation of MAP3K1 1 0.04 0.23 0
22 INT227837 Positive_regulation of Binding of CSH1 and ERCC6 1 0.20 0.15 0
23 INT189373 Rpa1 Negative_regulation of ERCC6 1 0.03 0 0
24 INT348521 TRAF2 Positive_regulation of MAP3K1 1 0.03 0.46 0
25 INT227829 CFC1 Positive_regulation of Gene_expression of ERCC6 1 0.03 0 0
26 INT227838 Binding of ERCC6 and PGBD3 1 0.40 0.23 0
27 INT348689 Fgf2 Regulation of Map3k1 1 0.09 0 0
28 INT189330 PPA1 Positive_regulation of ERCC6 1 0.10 0 0
29 INT227832 Binding of CSH1 and ERCC6 1 0.15 0.15 0
30 INT227841 PGBD1 Positive_regulation of ERCC6 1 0.44 0.29 0
31 INT274076 Binding of Map3k5 and Gmcl1 1 0.06 1.23 0
32 INT189333 CSNK2A1 Positive_regulation of Phosphorylation of ERCC6 1 0.10 0 0
33 INT227833 Positive_regulation of CFC1 Positive_regulation of Gene_expression of ERCC6 1 0.03 0 0
34 INT227840 Binding of ERCC2 and ERCC6 1 0.11 0.66 0
35 INT215416 MAP3K1 Regulation of MAPK9 1 0.14 0.64 0
36 INT215412 Binding of MAP3K1 and ITC1 1 0.03 0 0
37 INT227843 Binding of ERCC6 and MLL 1 0.00 0.34 0
38 INT189331 PPA1 Negative_regulation of Phosphorylation of ERCC6 1 0.06 0 0
39 INT215415 MAP3K1 Regulation of MAPK8 1 0.62 0.64 0
40 INT337406 Binding of TCF4 and TNIK 1 0.18 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of JNKK activity. They are ordered first by their pain relevance and then by number of times they were reported in activation of JNKK activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT159121 Positive_regulation of Map3k1 10 0.45 8.79 2.6
2 INT95400 Negative_regulation of Map3k1 3 0.15 0.78 1.92
3 INT71788 Gene_expression of MAP3K1 13 0.70 4.9 1.66
4 INT50785 Gene_expression of Map3k1 6 0.44 4.22 1.32
5 INT71784 Positive_regulation of Gene_expression of MAP3K1 4 0.34 4.8 0.82
6 INT50784 Positive_regulation of Gene_expression of Map3k1 2 0.06 0.94 0.8
7 INT177933 Positive_regulation of MAP3K1 6 0.42 4.13 0.76
8 INT130385 Gene_expression of ERCC6 7 0.77 8.36 0.63
9 INT111602 Negative_regulation of Gene_expression of MAP3K1 1 0.06 0.58 0.58
10 INT274072 Gene_expression of Map3k5 1 0.60 6.69 0.5
11 INT92328 Gene_expression of Map3k11 1 0.06 0.46 0.49
12 INT274069 Binding of Map3k5 1 0.29 2.68 0.49
13 INT95401 Phosphorylation of Map3k1 1 0.21 0.16 0.46
14 INT330099 Binding of Map3k11 1 0.24 1.21 0.31
15 INT102721 Negative_regulation of MAP3K1 2 0.53 8.03 0.3
16 INT177941 Phosphorylation of MAP3K1 2 0.20 1.31 0.24
17 INT189346 Positive_regulation of ERCC6 6 0.60 3.37 0.23
18 INT274071 Positive_regulation of Map3k5 3 0.38 2.31 0.22
19 INT98785 Negative_regulation of Gene_expression of Map3k1 1 0.03 0.69 0.21
20 INT344913 Regulation of Map3k5 1 0.48 0.61 0.2
21 INT227876 Transcription of ERCC6 1 0.68 1.87 0.17
22 INT257557 Negative_regulation of MAP3K11 3 0.30 2.38 0.16
23 INT189355 Phosphorylation of ERCC6 1 0.79 1.11 0.16
24 INT154200 Binding of Map3k1 1 0.06 0.32 0.16
25 INT182408 Localization of ERCC6 4 0.72 2.31 0.14
26 INT325046 Negative_regulation of Positive_regulation of Map3k5 1 0.07 0.64 0.11
27 INT151702 Binding of ERCC6 6 0.37 1.47 0.09
28 INT173169 Regulation of MAP3K1 2 0.41 1.81 0.09
29 INT92387 Gene_expression of Map3k1 1 0.02 1.13 0.09
30 INT227880 Positive_regulation of Transcription of ERCC6 1 0.50 0.52 0.09
31 INT250022 Regulation of Map3k1 2 0.18 1.02 0.04
32 INT274068 Positive_regulation of Gene_expression of Map3k5 1 0.53 2.85 0.03
33 INT141562 Negative_regulation of ERCC6 11 0.50 3.04 0
34 INT141563 Regulation of ERCC6 6 0.59 2.54 0
35 INT202475 Positive_regulation of Positive_regulation of Map3k1 2 0.33 1.54 0
36 INT227856 Regulation of Transcription of ERCC6 1 0.45 0 0
37 INT189352 Negative_regulation of Gene_expression of ERCC6 1 0.36 0 0
38 INT215426 Negative_regulation of Negative_regulation of MAP3K1 1 0.39 0.32 0
39 INT189345 Negative_regulation of Localization of ERCC6 1 0.41 0.06 0
40 INT274073 Negative_regulation of Map3k5 1 0.33 0.28 0
41 INT189990 Negative_regulation of Map3k1 1 0.01 1.48 0
42 INT333617 Transcription of MAP3K1 1 0.23 0.09 0
43 INT189344 Positive_regulation of Phosphorylation of ERCC6 1 0.58 0 0
44 INT215425 Positive_regulation of Negative_regulation of MAP3K1 1 0.45 0.78 0
45 INT189354 Negative_regulation of Phosphorylation of ERCC6 1 0.49 0 0
46 INT189358 Negative_regulation of Regulation of ERCC6 1 0.36 0 0
47 INT227866 Positive_regulation of Regulation of ERCC6 1 0.50 0.58 0
48 INT189357 Positive_regulation of Binding of ERCC6 1 0.42 0.15 0
49 INT215419 Regulation of Localization of MAP3K1 1 0.41 0.22 0
50 INT227883 Positive_regulation of Gene_expression of ERCC6 1 0.60 0.4 0
51 INT215423 Localization of MAP3K1 1 0.68 0.22 0
52 INT337476 Gene_expression of TNIK 1 0.43 0 0
53 INT227879 Regulation of Protein_catabolism of ERCC6 1 0.27 0.38 0
54 INT189356 Regulation of Regulation of ERCC6 1 0.59 0 0
55 INT333621 Positive_regulation of Transcription of MAP3K1 1 0.16 0.09 0
56 INT215428 Binding of MAP3K1 1 0.44 0.05 0
57 INT189361 Regulation of Phosphorylation of ERCC6 1 0.38 0.07 0
58 INT227875 Protein_catabolism of ERCC6 1 0.65 0.81 0
59 INT202470 Negative_regulation of Positive_regulation of Map3k1 1 0.38 0.62 0
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