GO:0007257

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Name activation of JUN kinase activity
Categary Process
Go Slim No
Go Link GO:0007257
Unique Molecular Interactions 265
Total Molecular Interactions 393
Total Single Events 1963
Pain Genes Associated 41

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for activation of JUN kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for activation of JUN kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
2 INT3573 Tf Negative_regulation of Localization of Gh1 1 0.36 0 1.49
3 INT264327 IL-17 Positive_regulation of Gene_expression of Tnfsf11 1 0.07 3.19 1.33
4 INT87026 ZAK Positive_regulation of Gene_expression of IL12A 3 0.12 2.55 1.26
5 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 0.11 1.59 1.02
6 INT181437 Binding of Ccr7 and Ccl21b 1 0.01 2.23 0.87
7 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86
8 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84
9 INT187229 Binding of Tnfsf11 and Insrr 1 0.00 2.06 0.78
10 INT207391 Il17a Positive_regulation of Gene_expression of Tnfsf11 2 0.05 1.19 0.77
11 INT135180 IL1B Positive_regulation of Gene_expression of TNFSF11 2 0.76 1.73 0.75
12 INT187231 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.18 1.8 0.71
13 INT107910 Binding of Tnfrsf11b and Tnfsf11 6 0.30 5.88 0.7
14 INT772 Tf Positive_regulation of Positive_regulation of Oprl1 1 0.11 0 0.7
15 INT778 Tf Positive_regulation of Gh1 1 0.14 0 0.7
16 INT782 Tf Positive_regulation of Prl 1 0.43 0 0.7
17 INT187220 Il11 Positive_regulation of Gene_expression of Tnfsf11 1 0.13 0.86 0.69
18 INT88194 ZAK Positive_regulation of Gene_expression of IL1B 1 0.07 0.94 0.66
19 INT330101 Binding of Map3k11 and Rac1 1 0.16 2.43 0.62
20 INT40901 Trf Regulation of Localization of POMC 1 0.07 0.56 0.6
21 INT54942 Rb1 Regulation of Gab1 1 0.02 0.39 0.59
22 INT87024 Positive_regulation of ZAK Positive_regulation of Localization of IFNG 2 0.05 0.81 0.58
23 INT209885 TNFSF11 Positive_regulation of TNFRSF11A 3 0.56 3.41 0.55
24 INT254279 Il13 Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.79 0.54
25 INT254280 Il4 Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.79 0.54
26 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
27 INT207396 IL6 Positive_regulation of Gene_expression of Tnfsf11 1 0.03 0.95 0.51
28 INT187227 Vip Negative_regulation of Gene_expression of Tnfsf11 1 0.35 1.23 0.51
29 INT207394 IL1B Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.95 0.51
30 INT207395 TNF Regulation of Gene_expression of Tnfsf11 1 0.11 0.91 0.49
31 INT231732 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.01 1.03 0.48
32 INT231733 Binding of Tnfrsf11a and Tnfsf11 1 0.01 1.03 0.48
33 INT95404 Map3k1 Positive_regulation of Phosphorylation of Ephb1 1 0.12 0.16 0.46
34 INT95408 Map3k1 Positive_regulation of Ephb1 1 0.12 0.16 0.46
35 INT155086 CASP1 Negative_regulation of DAXX 1 0.21 1.26 0.45
36 INT54945 Gab1 Regulation of Positive_regulation of Ltp 1 0.01 0.29 0.42
37 INT54946 Gab1 Regulation of Ltp 1 0.01 0.29 0.42
38 INT354704 Binding of MAP3K1 and Pick1 1 0.00 0.76 0.41
39 INT346130 Il17a Positive_regulation of Gene_expression of TNFSF11 1 0.08 0.61 0.41
40 INT88192 IFNG Regulation of Gene_expression of ZAK 1 0.01 0.75 0.36
41 INT87023 ZAK Positive_regulation of Gene_expression of IL36RN 1 0.03 0.62 0.36
42 INT210597 Negative_regulation of Binding of TNFSF11 and TNFRSF11A 3 0.26 5.66 0.33
43 INT165764 Tnfsf11 Positive_regulation of Mapk3 1 0.17 1.08 0.33
44 INT165765 Tnfsf11 Positive_regulation of Nfkb1 1 0.01 1.07 0.33
45 INT165763 Tnfsf11 Positive_regulation of Phosphorylation of Mapk3 1 0.40 1.08 0.33
46 INT151132 Negative_regulation of Map2k7 Negative_regulation of Gene_expression of Litaf 1 0.01 0.29 0.32
47 INT348016 Binding of Mapk8 and Mapk8ip3 1 0.04 2.09 0.32
48 INT255934 Tauph Positive_regulation of Map3k1 1 0.00 0.1 0.32
49 INT255946 MAPK14 Positive_regulation of Map3k1 1 0.04 0.1 0.32
50 INT187223 Il1 Positive_regulation of Gene_expression of Tnfsf11 1 0.09 0.64 0.32
51 INT188804 S100a8 Positive_regulation of Gene_expression of Tnfsf11 1 0.00 0.7 0.31
52 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31
53 INT54943 Gab1 Regulation of Rb1 1 0.02 0.2 0.31
54 INT144500 CCL3 Positive_regulation of Gene_expression of Tnfsf11 1 0.77 1.62 0.31
55 INT330100 Binding of Sh3rf1 and Map3k11 1 0.08 1.21 0.31
56 INT224422 Regulation of Binding of NFKB2 and TNFSF11 1 0.13 0.69 0.3
57 INT224418 Binding of NFKB2 and TNFSF11 1 0.11 0.68 0.3
58 INT162599 Wnt5a Regulation of Gene_expression of IL4I1 1 0.00 0.1 0.28
59 INT274932 Binding of Insrr and Map3k1 1 0.00 0 0.28
60 INT274947 Binding of Map3k1 and Grip1 1 0.00 0 0.27
61 INT3577 Tf Negative_regulation of Positive_regulation of Gh1 1 0.49 0 0.27
62 INT171912 MAPK8IP3 Positive_regulation of MAPK9 1 0.06 0.78 0.26
63 INT171911 MAPK8IP3 Positive_regulation of Gene_expression of MAPK14 1 0.05 0.77 0.26
64 INT302818 Gcat Negative_regulation of Syk 1 0.00 0.53 0.24
65 INT292554 MAP3K5 Positive_regulation of MAPK8 1 0.08 0 0.23
66 INT292561 MAP3K5 Positive_regulation of Positive_regulation of RAC1 1 0.03 0 0.23
67 INT292565 MAP3K5 Positive_regulation of Positive_regulation of CDC42 1 0.02 0 0.23
68 INT88191 Binding of NCOR2 and ZAK 1 0.00 0.17 0.21
69 INT301279 Tnfsf11 Regulation of Gene_expression of Mmp9 1 0.13 0.34 0.21
70 INT355103 Binding of Ins2 and Ins1 1 0.12 2 0.21
71 INT171973 Tnfsf11 Positive_regulation of Gene_expression of Il1 1 0.06 0.21 0.21
72 INT171972 Tnfsf11 Positive_regulation of Gene_expression of Il6 1 0.08 0.21 0.21
73 INT301281 Tnfsf11 Regulation of Gene_expression of Clec5a 1 0.22 0.34 0.21
74 INT188801 Il6 Positive_regulation of Positive_regulation of Tnfsf11 1 0.06 0.46 0.21
75 INT45934 PKN1 Regulation of NOTCH2NL 1 0.01 0 0.2
76 INT45933 PKN1 Regulation of PKN3 1 0.05 0 0.2
77 INT301290 Tnfsf11 Positive_regulation of Nfatc1 1 0.15 0.65 0.2
78 INT301282 Tnfsf11 Positive_regulation of Traf6 1 0.10 0.65 0.2
79 INT355364 Regulation of PTHLH Positive_regulation of Tnfsf11 1 0.04 1.51 0.19
80 INT355363 PTHLH Positive_regulation of Tnfsf11 1 0.04 1.47 0.19
81 INT355365 CSF1 Positive_regulation of Tnfsf11 1 0.03 1.49 0.19
82 INT355366 Regulation of CSF1 Positive_regulation of Tnfsf11 1 0.02 1.5 0.19
83 INT334267 Mul1 Positive_regulation of Protein_catabolism of Tlr4 1 0.01 0.18 0.18
84 INT148531 Binding of TNFRSF11A and Tnfsf11 2 0.08 1.77 0.17
85 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17
86 INT254214 Binding of Myd88 and Tirap 1 0.15 0.55 0.17
87 INT348034 Mapk8ip3 Negative_regulation of Mapk8 1 0.05 0.98 0.16
88 INT348019 Negative_regulation of Binding of Mapk8 and Mapk8ip3 1 0.05 1.04 0.16
89 INT278373 Myd88 Regulation of Phosphorylation of Syk 1 0.15 0.35 0.15
90 INT148532 Binding of CCL3 and Tnfsf11 1 0.03 0.71 0.14
91 INT177916 PRKG1 Positive_regulation of Positive_regulation of MAP3K1 1 0.05 1.07 0.14
92 INT81992 IL1A Positive_regulation of Positive_regulation of Tnfsf11 1 0.05 0.27 0.13
93 INT352073 Positive_regulation of Binding of ADAM11 and CCL19 1 0.22 1.27 0.13
94 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13
95 INT352080 Binding of ADAM11 and CCL19 1 0.16 1.27 0.13
96 INT321404 Positive_regulation of MAP3K5 Positive_regulation of Gene_expression of SERPINE1 1 0.02 2.2 0.12
97 INT332687 Ros1 Positive_regulation of Crk 1 0.17 0.77 0.12
98 INT101339 ZAK Regulation of Gene_expression of AXL 1 0.01 0.32 0.12
99 INT280488 Bdnf Positive_regulation of Gene_expression of Map3k1 1 0.01 1.49 0.11
100 INT301284 Tnfsf11 Positive_regulation of Localization of Nfatc1 1 0.16 0.32 0.11
101 INT93535 PTH Negative_regulation of Gene_expression of Tnfsf11 1 0.19 0.22 0.11
102 INT107909 Binding of Tnfsf11 and Tnfrsf22 1 0.01 2.12 0.11
103 INT275451 Binding of ZAP70 and Syk 1 0.02 0.12 0.1
104 INT226210 Akt1 Regulation of Mul1 1 0.04 0.6 0.1
105 INT275450 Binding of STAM and Syk 1 0.00 0.12 0.1
106 INT233510 Wnt5a Positive_regulation of Gene_expression of Il12a 1 0.03 0.33 0.1
107 INT254284 Binding of TNF and Tnfsf11 1 0.04 0.44 0.1
108 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09
109 INT92389 ALK Positive_regulation of Gene_expression of Map3k1 1 0.01 1.14 0.09
110 INT232559 Map3k1 Positive_regulation of Esr1 1 0.19 0.26 0.09
111 INT210595 Binding of TNF and TNFSF11 1 0.10 5.13 0.09
112 INT295003 Binding of Tnfrsf11b and Tnfsf11 3 0.22 1.85 0.08
113 INT211960 Wnt5a Positive_regulation of Car2 1 0.13 0.38 0.08
114 INT210600 IL1B Regulation of TNFSF11 1 0.04 1.45 0.08
115 INT338999 Binding of BTF3P11 and Tnfsf11 1 0.01 0.35 0.08
116 INT210601 IL8 Positive_regulation of TNFSF11 1 0.06 1.46 0.08
117 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08
118 INT321867 TNFRSF11B Negative_regulation of TNFSF11 1 0.00 0.85 0.08
119 INT205158 Gene_expression of SPP1 Positive_regulation of Gene_expression of TNFSF11 1 0.11 1.08 0.08
120 INT334061 Negative_regulation of Binding of TNFRSF11A and Tnfsf11 1 0.01 0.52 0.08
121 INT321868 Binding of TNFRSF11B and Negative_regulation of TNFSF11 1 0.00 0.91 0.08
122 INT210599 IL8 Regulation of TNFSF11 1 0.05 1.44 0.08
123 INT254277 Binding of Hand1 and Tnfsf11 1 0.02 0.08 0.08
124 INT227836 Binding of ERCC6 and GPER 1 0.21 0.27 0.08
125 INT297964 Binding of CDK8 and MAP3K11 1 0.26 0.29 0.07
126 INT269334 Regulation of PRKCA Regulation of ZAK 1 0.02 0 0.07
127 INT297969 Positive_regulation of Binding of CDK8 and MAP3K11 1 0.35 0.29 0.07
128 INT269328 PRKCA Regulation of ZAK 1 0.02 0 0.07
129 INT338429 Il9 Positive_regulation of Gene_expression of Fcer1a 1 0.05 0.31 0.07
130 INT269331 PRKG1 Regulation of ZAK 1 0.03 0 0.07
131 INT269329 Regulation of PRKG1 Regulation of ZAK 1 0.03 0 0.07
132 INT127722 CSF1 Positive_regulation of TNFSF11 1 0.08 0.26 0.06
133 INT350482 Tirap Regulation of TICAM2 1 0.05 0.06 0.06
134 INT350478 Tirap Regulation of Ticam1 1 0.07 0.06 0.05
135 INT217472 Binding of Nup62 and Mul1 1 0.12 0 0.05
136 INT217468 Positive_regulation of Binding of Nup62 and Mul1 1 0.16 0 0.05
137 INT314369 Tnfsf11 Negative_regulation of Gene_expression of Tnfrsf11b 1 0.08 2.2 0.05
138 INT224421 TNFRSF11B Regulation of TNFSF11 1 0.27 0 0.05
139 INT120573 Positive_regulation of Binding of Egfr and Gab1 1 0.63 1.22 0.05
140 INT120571 Binding of Egfr and Gab1 1 0.44 1.21 0.05
141 INT210596 TNFRSF11B Negative_regulation of Binding of TNFSF11 2 0.11 1.62 0.04
142 INT354715 Binding of PKN1 and Pick1 1 0.01 0.19 0.04
143 INT326625 Binding of ALB and Trf 1 0.01 0.64 0.04
144 INT202546 Binding of FCER1A and IGHE 1 0.02 0.49 0.04
145 INT232206 Binding of Tgfb1 and Tnfsf11 1 0.02 0.52 0.04
146 INT210598 PTHLH Positive_regulation of Gene_expression of TNFSF11 1 0.23 0.98 0.04
147 INT354682 Binding of ASIC1 and PKN1 1 0.01 0.19 0.04
148 INT217474 Tnfrsf11a Regulation of Gene_expression of Tnfsf11 1 0.41 1.2 0.04
149 INT250025 Map3k1 Positive_regulation of Regulation of Bcl2 1 0.01 1.1 0.04
150 INT223826 GSTM1 Negative_regulation of MAP3K5 1 0.02 0.71 0.03
151 INT223824 Binding of GSTM1 and MAP3K5 1 0.02 0.68 0.03
152 INT352074 ADAM11 Positive_regulation of Gene_expression of CCL19 1 0.17 0.74 0.03
153 INT340276 Tnfsf11 Positive_regulation of Localization of RELA 1 0.02 0.58 0.03
154 INT278404 Syk Positive_regulation of Mapk1 1 0.13 0 0
155 INT189375 Rpa1 Regulation of ERCC6 1 0.04 0.05 0
156 INT165988 PTGER1 Positive_regulation of TNFSF11 1 0.05 0.13 0
157 INT227830 CSH1 Regulation of ERCC6 1 0.11 0 0
158 INT340270 Negative_regulation of Tnfsf11 Positive_regulation of TRAP 1 0.03 0.37 0
159 INT343744 mn Negative_regulation of Regulation of Wnt7a 1 0.01 0.1 0
160 INT205159 SPP1 Positive_regulation of Gene_expression of TNFSF11 1 0.11 0.8 0
161 INT215413 ITC1 Negative_regulation of MAP3K1 1 0.04 0.23 0
162 INT227837 Positive_regulation of Binding of CSH1 and ERCC6 1 0.20 0.15 0
163 INT178440 Map2k4 Positive_regulation of Mapk14 1 0.04 0.13 0
164 INT283183 Binding of S100A4 and ZAK 1 0.06 0 0
165 INT268199 Rab22a Regulation of Trf 1 0.11 0.17 0
166 INT189373 Rpa1 Negative_regulation of ERCC6 1 0.03 0 0
167 INT278400 Negative_regulation of Syk Negative_regulation of Positive_regulation of Hps5 1 0.16 0 0
168 INT278382 Binding of Syk and Nlrp3 1 0.24 0 0
169 INT338828 Binding of Trf and TMPRSS6 1 0.05 0.1 0
170 INT335884 Akt1 Regulation of Positive_regulation of Wnt5a 1 0.03 0.15 0
171 INT348521 TRAF2 Positive_regulation of MAP3K1 1 0.03 0.46 0
172 INT278401 Syk Regulation of Positive_regulation of Hps5 1 0.19 0 0
173 INT227829 CFC1 Positive_regulation of Gene_expression of ERCC6 1 0.03 0 0
174 INT298585 TNFSF11 Positive_regulation of ACP5 1 0.16 0.09 0
175 INT165986 PTGER1 Regulation of Positive_regulation of TNFSF11 1 0.04 0.12 0
176 INT210581 Binding of AMELX and Tnfsf11 1 0.01 0.15 0
177 INT227838 Binding of ERCC6 and PGBD3 1 0.40 0.23 0
178 INT278410 Gopc Positive_regulation of Phosphorylation of Syk 1 0.10 0.23 0
179 INT339708 MBL2 Regulation of MAP3K2 1 0.00 0.1 0
180 INT348689 Fgf2 Regulation of Map3k1 1 0.09 0 0
181 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0
182 INT104866 ZAK Positive_regulation of NXT1 1 0.07 0 0
183 INT303394 Binding of Myh3 and Mul1 1 0.04 0.38 0
184 INT339706 LGALS2 Regulation of MAP3K2 1 0.00 0.1 0
185 INT189330 PPA1 Positive_regulation of ERCC6 1 0.10 0 0
186 INT317302 Binding of Park2 and Mul1 1 0.01 0.62 0
187 INT278387 Syk Regulation of Positive_regulation of Il1 1 0.06 0 0
188 INT236724 Binding of AXIN1 and Ctnnd2 1 0.39 1.03 0
189 INT227832 Binding of CSH1 and ERCC6 1 0.15 0.15 0
190 INT178445 Map2k4 Positive_regulation of Mapk8 1 0.11 0.13 0
191 INT227841 PGBD1 Positive_regulation of ERCC6 1 0.44 0.29 0
192 INT278372 Binding of Syk and Pycard 1 0.06 0 0
193 INT175400 RASGRP1 Positive_regulation of MAP3K5 1 0.00 1.2 0
194 INT298586 PTGER2 Regulation of Gene_expression of TNFSF11 1 0.06 0 0
195 INT217480 Tnfsf11 Negative_regulation of Tnfrsf11a 1 0.39 0.75 0
196 INT298587 TNFSF11 Regulation of IL1B 1 0.18 0 0
197 INT286420 Binding of Fgf13 and Mapk8ip3 1 0.36 0 0
198 INT270778 Binding of TNFSF11 and CALCRL 1 0.00 0.44 0
199 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
200 INT189333 CSNK2A1 Positive_regulation of Phosphorylation of ERCC6 1 0.10 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for activation of JUN kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in activation of JUN kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66
2 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53
3 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34
4 INT119729 Binding of Tnfsf11 31 0.35 24.02 7.45
5 INT104207 Positive_regulation of Gene_expression of Tnfsf11 43 0.69 25.8 7.35
6 INT136555 Negative_regulation of Tnfsf11 31 0.55 22.23 6.23
7 INT12194 Gene_expression of Trf 38 0.69 18.1 4.56
8 INT11565 Gene_expression of Tf 24 0.68 5.89 4.36
9 INT166966 Gene_expression of Ccr7 14 0.48 7.36 4.2
10 INT134646 Gene_expression of Tnfsf11 19 0.69 14.77 4.16
11 INT108481 Positive_regulation of CCL19 4 0.44 15.22 3.77
12 INT108484 Gene_expression of CCL19 4 0.50 12.56 3.63
13 INT88197 Binding of ZAK 9 0.46 6.23 3.54
14 INT133086 Positive_regulation of Phosphorylation of Map2k7 1 0.05 4.34 3.27
15 INT133082 Phosphorylation of Map2k7 5 0.15 4.27 3.05
16 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99
17 INT46650 Localization of Trf 13 0.61 4.4 2.91
18 INT93531 Negative_regulation of Gene_expression of Tnfsf11 15 0.43 7.74 2.84
19 INT132846 Localization of Tnfsf11 17 0.69 10.28 2.78
20 INT17033 Positive_regulation of Trf 21 0.62 11.76 2.68
21 INT159121 Positive_regulation of Map3k1 10 0.45 8.79 2.6
22 INT81989 Positive_regulation of Tnfsf11 11 0.54 7.57 2.4
23 INT144490 Regulation of Gene_expression of Tnfsf11 14 0.58 14.09 2.39
24 INT93532 Regulation of Tnfsf11 14 0.42 10.75 2.39
25 INT24129 Positive_regulation of ZAK 13 0.70 2.29 2.39
26 INT128926 Gene_expression of Map2k7 5 0.23 3.01 2.31
27 INT55090 Positive_regulation of Wnt7a 13 0.37 2.25 2.2
28 INT278340 Gene_expression of Syk 7 0.51 4.92 2.09
29 INT135523 Gene_expression of MAP3K2 2 0.53 1.22 2.03
30 INT83329 Regulation of Gene_expression of Tf 4 0.16 1.83 1.93
31 INT48850 Gene_expression of PKN1 16 0.52 1.93 1.92
32 INT95400 Negative_regulation of Map3k1 3 0.15 0.78 1.92
33 INT36499 Negative_regulation of Tf 6 0.38 3.02 1.85
34 INT130866 Positive_regulation of Gene_expression of TNFSF11 25 0.69 7.11 1.82
35 INT133084 Positive_regulation of Gene_expression of Map2k7 3 0.17 2.56 1.8
36 INT108486 Positive_regulation of Gene_expression of CCL19 2 0.45 6.2 1.79
37 INT71788 Gene_expression of MAP3K1 13 0.70 4.9 1.66
38 INT182643 Binding of TNFSF11 15 0.35 13.12 1.61
39 INT88195 Gene_expression of ZAK 15 0.74 4.79 1.55
40 INT162057 Negative_regulation of TNFSF11 14 0.58 9.78 1.46
41 INT105551 Transcription of Tnfsf11 6 0.69 4.21 1.38
42 INT16239 Negative_regulation of Trf 9 0.32 4.06 1.35
43 INT50785 Gene_expression of Map3k1 6 0.44 4.22 1.32
44 INT36500 Negative_regulation of Gene_expression of Tf 4 0.38 1.22 1.29
45 INT135181 Regulation of Gene_expression of TNFSF11 5 0.61 6.98 1.27
46 INT85672 Phosphorylation of MAP3K2 2 0.18 0.62 1.26
47 INT135186 Negative_regulation of Gene_expression of TNFSF11 10 0.58 2.69 1.25
48 INT36443 Regulation of Trf 4 0.61 1.65 1.18
49 INT769 Regulation of Tf 3 0.30 1 1.18
50 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17
51 INT105552 Positive_regulation of Transcription of Tnfsf11 3 0.31 2.94 1.17
52 INT152010 Positive_regulation of Ccr7 3 0.47 1.46 1.15
53 INT224429 Regulation of TNFSF11 8 0.61 4.35 1.13
54 INT210586 Negative_regulation of Positive_regulation of Tnfsf11 3 0.41 1.4 1.02
55 INT127647 Regulation of Wnt7a 3 0.07 1.28 1.01
56 INT181354 Binding of Ccr7 2 0.23 1.94 1.01
57 INT132847 Negative_regulation of Localization of Tnfsf11 1 0.32 0.16 1.01
58 INT3568 Localization of Tf 4 0.62 1.27 1
59 INT275940 Negative_regulation of Syk 3 0.39 2.08 0.95
60 INT171963 Positive_regulation of Positive_regulation of Tnfsf11 3 0.42 2.44 0.93
61 INT89368 Positive_regulation of Tf 7 0.34 3.62 0.83
62 INT126572 Positive_regulation of SYK 3 0.67 2.98 0.83
63 INT167833 Positive_regulation of Ins2 4 0.50 6.52 0.82
64 INT71784 Positive_regulation of Gene_expression of MAP3K1 4 0.34 4.8 0.82
65 INT50784 Positive_regulation of Gene_expression of Map3k1 2 0.06 0.94 0.8
66 INT294998 Positive_regulation of Gene_expression of Tnfsf11 5 0.62 2.98 0.79
67 INT54940 Positive_regulation of Gab1 1 0.04 0.48 0.79
68 INT48851 Positive_regulation of Gene_expression of PKN1 2 0.27 0.67 0.78
69 INT108044 Phosphorylation of Syk 3 0.25 1.39 0.77
70 INT177933 Positive_regulation of MAP3K1 6 0.42 4.13 0.76
71 INT144880 Negative_regulation of DAXX 4 0.23 2.15 0.73
72 INT298598 Positive_regulation of Positive_regulation of TNFSF11 2 0.38 1.26 0.72
73 INT165760 Positive_regulation of Binding of Tnfsf11 2 0.36 1.83 0.71
74 INT24128 Negative_regulation of ZAK 3 0.39 0 0.7
75 INT185729 Negative_regulation of Gene_expression of Tnfsf11 3 0.52 2.07 0.69
76 INT128925 Negative_regulation of Map2k7 2 0.10 0.66 0.68
77 INT33317 Negative_regulation of RIPK1 1 0.31 0.05 0.67
78 INT205171 Localization of TNFSF11 4 0.74 3.94 0.66
79 INT312830 Regulation of Ins2 2 0.39 1.45 0.66
80 INT28958 Negative_regulation of Wnt7a 3 0.45 0.49 0.65
81 INT130385 Gene_expression of ERCC6 7 0.77 8.36 0.63
82 INT264991 Positive_regulation of Localization of Tnfsf11 5 0.24 3.22 0.59
83 INT150075 Positive_regulation of Gene_expression of WNT5A 2 0.67 2.53 0.59
84 INT132324 Localization of SYK 2 0.78 1.9 0.59
85 INT278152 Negative_regulation of Syk 1 0.24 1.93 0.59
86 INT54939 Regulation of Gab1 1 0.04 0.39 0.59
87 INT111602 Negative_regulation of Gene_expression of MAP3K1 1 0.06 0.58 0.58
88 INT53195 Localization of ZAK 3 0.80 1.85 0.56
89 INT127648 Gene_expression of Wnt7a 2 0.13 1.11 0.56
90 INT179405 Positive_regulation of Map2k7 1 0.16 1.32 0.55
91 INT132325 Positive_regulation of Localization of SYK 1 0.49 0.56 0.54
92 INT149394 Positive_regulation of Mul1 4 0.12 1.89 0.53
93 INT172310 Positive_regulation of PKN1 6 0.12 2 0.51
94 INT151125 Negative_regulation of Localization of Map2k7 1 0.08 0.61 0.51
95 INT128924 Regulation of Map2k7 3 0.08 0.87 0.5
96 INT154180 Negative_regulation of SYK 3 0.43 4.67 0.5
97 INT207379 Regulation of Negative_regulation of Tnfsf11 2 0.28 1.7 0.5
98 INT151121 Localization of Map2k7 1 0.14 0.59 0.5
99 INT284454 Binding of Tirap 4 0.26 2.07 0.49
100 INT92328 Gene_expression of Map3k11 1 0.06 0.46 0.49
101 INT72750 Regulation of Positive_regulation of ZAK 1 0.10 0 0.49
102 INT302775 Negative_regulation of Gene_expression of Syk 1 0.27 0.84 0.48
103 INT98946 Negative_regulation of Phosphorylation of MAP3K2 1 0.13 0.62 0.47
104 INT354384 Regulation of CCL19 1 0.23 1.89 0.47
105 INT312821 Binding of Ins2 2 0.37 2.13 0.46
106 INT95401 Phosphorylation of Map3k1 1 0.21 0.16 0.46
107 INT210125 Regulation of Axin1 1 0.02 2.45 0.46
108 INT155088 Positive_regulation of DAXX 1 0.22 1.27 0.45
109 INT53667 Gene_expression of Ins2 10 0.65 5.65 0.44
110 INT340265 Localization of Tnfsf11 2 0.30 1.65 0.44
111 INT341289 Positive_regulation of Localization of Tnfsf11 1 0.13 1.26 0.44
112 INT154182 Phosphorylation of SYK 6 0.82 5.54 0.43
113 INT181358 Transcription of Ccr7 1 0.43 1.33 0.43
114 INT137846 Regulation of Tnfsf11 5 0.48 1.62 0.42
115 INT54937 Negative_regulation of Gab1 1 0.03 0.27 0.42
116 INT202347 Gene_expression of Map2k4 13 0.74 11.68 0.4
117 INT165761 Phosphorylation of Tnfsf11 3 0.75 2.76 0.4
118 INT312829 Positive_regulation of Positive_regulation of Ins2 1 0.50 1.73 0.4
119 INT94933 Positive_regulation of Gene_expression of Bcl10 1 0.01 1.74 0.38
120 INT187214 Negative_regulation of Binding of Tnfsf11 1 0.25 1.01 0.38
121 INT154181 Positive_regulation of Phosphorylation of SYK 4 0.70 4.71 0.37
122 INT128918 Negative_regulation of Gene_expression of Map2k7 1 0.02 0.37 0.37
123 INT321424 Positive_regulation of MAP3K5 1 0.18 6.64 0.37
124 INT135188 Transcription of TNFSF11 4 0.59 0.72 0.36
125 INT274074 Binding of Map2k4 1 0.08 1.98 0.36
126 INT181575 Phosphorylation of Crk 1 0.61 1.78 0.36
127 INT46843 Binding of Trf 10 0.47 3.45 0.35
128 INT231102 Gene_expression of Mul1 8 0.21 1.66 0.35
129 INT30049 Gene_expression of Bcl10 4 0.51 2.36 0.35
130 INT154175 Regulation of SYK 2 0.62 1.48 0.34
131 INT343970 Regulation of ZAK 1 0.07 0.14 0.34
132 INT181580 Gene_expression of Crk 1 0.75 1.2 0.33
133 INT295000 Binding of Tnfsf11 5 0.32 2.27 0.32
134 INT108043 Negative_regulation of Phosphorylation of Syk 1 0.13 0.53 0.31
135 INT91692 Positive_regulation of Binding of ZAK 1 0.44 0.76 0.31
136 INT330099 Binding of Map3k11 1 0.24 1.21 0.31
137 INT71292 Binding of Tf 5 0.27 1.58 0.3
138 INT102721 Negative_regulation of MAP3K1 2 0.53 8.03 0.3
139 INT154559 Positive_regulation of Syk 2 0.20 0.74 0.3
140 INT66060 Regulation of Gene_expression of PKN1 1 0.23 0 0.3
141 INT202360 Positive_regulation of Map2k4 2 0.48 9.89 0.29
142 INT154074 Positive_regulation of Gene_expression of Tf 4 0.46 1.64 0.28
143 INT45236 Positive_regulation of Gene_expression of Trf 3 0.62 1.67 0.28
144 INT324677 Gene_expression of Tirap 3 0.47 0.21 0.26
145 INT278155 Regulation of Negative_regulation of Syk 1 0.18 0.55 0.26
146 INT287251 Negative_regulation of PKN1 6 0.01 1.86 0.25
147 INT321428 Positive_regulation of Positive_regulation of MAP3K5 1 0.13 4.65 0.25
148 INT137847 Negative_regulation of Tnfsf11 4 0.42 1.31 0.24
149 INT177941 Phosphorylation of MAP3K1 2 0.20 1.31 0.24
150 INT305840 Positive_regulation of Gene_expression of Ccr7 1 0.27 0.25 0.24
151 INT189346 Positive_regulation of ERCC6 6 0.60 3.37 0.23
152 INT252723 Gene_expression of SYK 3 0.25 2.67 0.23
153 INT210588 Protein_catabolism of Tnfsf11 1 0.72 1.43 0.23
154 INT278154 Regulation of Syk 1 0.05 0.98 0.22
155 INT278147 Localization of Syk 1 0.30 0.98 0.22
156 INT98785 Negative_regulation of Gene_expression of Map3k1 1 0.03 0.69 0.21
157 INT231095 Positive_regulation of Gene_expression of Mul1 1 0.13 0.82 0.19
158 INT151131 Negative_regulation of Phosphorylation of Map2k7 1 0.10 0.31 0.19
159 INT233130 Regulation of PKN1 2 0.02 0.69 0.18
160 INT312822 Regulation of Transcription of Ins2 1 0.45 0.71 0.18
161 INT220167 Localization of Ccr7 1 0.31 0.39 0.18
162 INT312825 Transcription of Ins2 1 0.69 0.7 0.18
163 INT227876 Transcription of ERCC6 1 0.68 1.87 0.17
164 INT210123 Localization of Axin1 1 0.04 0.84 0.17
165 INT66933 Binding of AXIN1 6 0.32 1.8 0.16
166 INT257557 Negative_regulation of MAP3K11 3 0.30 2.38 0.16
167 INT240602 Gene_expression of RIPK1 2 0.58 0.69 0.16
168 INT55089 Positive_regulation of Positive_regulation of Wnt7a 2 0.27 0.06 0.16
169 INT189355 Phosphorylation of ERCC6 1 0.79 1.11 0.16
170 INT154200 Binding of Map3k1 1 0.06 0.32 0.16
171 INT275937 Phosphorylation of Syk 3 0.54 1.67 0.15
172 INT182408 Localization of ERCC6 4 0.72 2.31 0.14
173 INT287249 Localization of PKN1 3 0.03 0.78 0.14
174 INT354092 Positive_regulation of Positive_regulation of Trf 1 0.07 0.38 0.14
175 INT154177 Negative_regulation of Phosphorylation of SYK 1 0.43 1.51 0.14
176 INT263410 Negative_regulation of Axin1 1 0.01 0 0.14
177 INT294997 Regulation of Gene_expression of Tnfsf11 1 0.35 0.81 0.13
178 INT111656 Regulation of Mul1 1 0.02 0.08 0.13
179 INT263138 Phosphorylation of ZAK 5 0.17 0.13 0.12
180 INT312828 Negative_regulation of Gene_expression of Ins2 1 0.37 0.8 0.12
181 INT302772 Regulation of Map2k7 1 0.02 0.33 0.11
182 INT162574 Gene_expression of Wnt5a 7 0.47 0.92 0.1
183 INT210605 Negative_regulation of Negative_regulation of TNFSF11 2 0.42 1.65 0.1
184 INT282594 Localization of WNT5A 2 0.18 0.89 0.1
185 INT233483 Regulation of Gene_expression of Wnt5a 1 0.19 0.33 0.1
186 INT275411 Binding of Syk 1 0.09 0.12 0.1
187 INT151702 Binding of ERCC6 6 0.37 1.47 0.09
188 INT273866 Binding of Mul1 4 0.11 0.69 0.09
189 INT188350 Localization of Map2k4 2 0.67 0.46 0.09
190 INT173169 Regulation of MAP3K1 2 0.41 1.81 0.09
191 INT355099 Localization of Ins2 1 0.44 0.83 0.09
192 INT92387 Gene_expression of Map3k1 1 0.02 1.13 0.09
193 INT312832 Negative_regulation of Ins2 1 0.37 0.64 0.09
194 INT227880 Positive_regulation of Transcription of ERCC6 1 0.50 0.52 0.09
195 INT61207 Regulation of Gene_expression of Trf 1 0.02 0.79 0.09
196 INT162576 Positive_regulation of Wnt5a 3 0.48 0.71 0.08
197 INT294014 Regulation of AXIN1 3 0.24 1.04 0.08
198 INT145364 Negative_regulation of AXIN1 2 0.33 0.52 0.08
199 INT347978 Positive_regulation of Phosphorylation of Map2k7 1 0.27 1.08 0.08
200 INT199076 Positive_regulation of Syk 3 0.31 0.12 0.07
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