GO:0007259

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Name JAK-STAT cascade
Categary Process
Go Slim No
Go Link GO:0007259
Unique Molecular Interactions 1142
Total Molecular Interactions 1692
Total Single Events 14866
Pain Genes Associated 48

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for JAK-STAT cascade. They are ordered first by their pain relevance and then by number of times they were reported for JAK-STAT cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 0.64 2.12 14.2
2 INT26468 Ghrh Positive_regulation of Localization of Gh 21 0.37 3.26 9.21
3 INT10844 Ghrh Regulation of Gh 13 0.13 4.77 4.71
4 INT16221 Ghrh Positive_regulation of Gh 8 0.21 1.89 4.08
5 INT11248 Gh Positive_regulation of Ghrh 2 0.26 0.09 4.04
6 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81
7 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
8 INT13729 GHRH Positive_regulation of Localization of GH1 13 0.62 0.59 3.2
9 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17
10 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
11 INT26892 OGG1 Negative_regulation of Gene_expression of Gh1 1 0.12 0 2.53
12 INT20411 Ghrh Positive_regulation of Gh1 6 0.56 0.62 2.47
13 INT7367 Ghrh Regulation of Localization of Gh1 5 0.49 1.55 2.25
14 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
15 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
16 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
17 INT9180 Ghrh Regulation of Localization of Gh 3 0.24 0.25 2.18
18 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
19 INT3576 Sst Negative_regulation of Localization of Gh1 6 0.23 0 2.13
20 INT319581 Binding of PIAS1 and TNFSF14 1 0.02 1.58 2.13
21 INT26948 Pomc Positive_regulation of Localization of Gh1 2 0.22 0.15 1.99
22 INT83170 Lep Regulation of Cck 5 0.43 0.68 1.96
23 INT116815 Binding of Pias1 and Ppbp 1 0.36 0.86 1.92
24 INT16891 GHRH Regulation of GH1 5 0.37 1.94 1.82
25 INT266391 Binding of Ager and S100a1 1 0.01 5.63 1.69
26 INT40827 Sstr1 Negative_regulation of Localization of Gh1 1 0.13 0 1.58
27 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
28 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
29 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
30 INT3573 Tf Negative_regulation of Localization of Gh1 1 0.36 0 1.49
31 INT34834 Ghrh Positive_regulation of Gene_expression of Gh1 2 0.65 0 1.4
32 INT26893 OGG1 Negative_regulation of Gh1 1 0.12 0 1.37
33 INT52568 HTR1D Regulation of Localization of Gh 2 0.20 0.16 1.34
34 INT142207 Adcyap1 Positive_regulation of Localization of Gh 1 0.07 0 1.3
35 INT48117 GH1 Positive_regulation of CGA 1 0.10 0 1.28
36 INT74467 Adcyap1 Positive_regulation of Localization of Gh1 1 0.37 0 1.25
37 INT70570 su Positive_regulation of Gh 1 0.01 0.15 1.24
38 INT200455 OPRK1 Positive_regulation of Gene_expression of CCL2 1 0.19 0.07 1.21
39 INT290667 Il6 Positive_regulation of Stat3 3 0.69 2.42 1.15
40 INT32480 Gh1 Positive_regulation of Gene_expression of Ghrh 1 0.35 0 1.15
41 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
42 INT14199 GNRH1 Positive_regulation of Localization of Gh1 2 0.05 0 1.12
43 INT260810 Binding of CXCL10 and CCL2 1 0.10 1.37 1.12
44 INT333966 Binding of Il6r and Il6st 1 0.01 1.74 1.1
45 INT19887 GHRH Positive_regulation of Positive_regulation of GH1 2 0.56 0.3 1.08
46 INT14197 Pde2a Positive_regulation of Localization of Gh1 2 0.04 0 1.08
47 INT33338 Adarb1 Positive_regulation of Localization of Gh1 1 0.04 0 1.08
48 INT33336 Adarb1 Positive_regulation of Negative_regulation of Gh1 1 0.03 0 1.08
49 INT33337 Adarb1 Positive_regulation of Gh1 1 0.03 0 1.08
50 INT118859 GNA14 Positive_regulation of STAT3 1 0.01 0.38 1.03
51 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
52 INT148327 Binding of Pkd1 and Trpv1 1 0.52 2.23 1.01
53 INT117311 HP Positive_regulation of Lep 1 0.00 1.78 1.01
54 INT35157 GH1 Regulation of GHRH 3 0.17 0.5 0.99
55 INT41659 IL31RA Regulation of PRL 1 0.22 1.07 0.98
56 INT41658 IL31RA Regulation of GH1 1 0.09 1.07 0.98
57 INT19758 Ghrh Positive_regulation of Positive_regulation of Gh 1 0.26 0 0.98
58 INT137919 Binding of Oprm1 and Stat3 1 0.30 0 0.97
59 INT286798 Binding of Il6st and Cntf 1 0.10 1.34 0.97
60 INT140068 Binding of GH1 and Ghsr 1 0.00 0.47 0.97
61 INT36682 Gh1 Regulation of Gene_expression of Gnrhr 2 0.08 0 0.96
62 INT36683 Gh1 Regulation of Gnrhr 3 0.08 1.25 0.95
63 INT31108 Ghrh Negative_regulation of Gh1 2 0.55 0 0.95
64 INT135585 CSF2 Regulation of CCL2 1 0.13 2.51 0.95
65 INT62106 Ghrh Negative_regulation of Localization of Gh 1 0.06 0 0.94
66 INT62109 SLC25A4 Negative_regulation of Localization of Gh 1 0.06 0 0.94
67 INT139330 Binding of SGCG and Stat1 1 0.37 0.75 0.94
68 INT35252 Gene_expression of Ghrh Positive_regulation of Localization of Gh1 1 0.49 0 0.93
69 INT45279 Binding of CSF2 and GHR 1 0.05 0.07 0.93
70 INT39201 Olr824 Positive_regulation of Localization of Gh1 1 0.03 0 0.91
71 INT48113 GH1 Positive_regulation of Localization of CGA 1 0.07 0 0.9
72 INT30411 Ghrh Regulation of Gene_expression of Gh1 1 0.40 0.12 0.9
73 INT35160 GH1 Regulation of PRL 2 0.37 0 0.89
74 INT61046 Oprm1 Positive_regulation of Gh1 1 0.21 0 0.89
75 INT61047 Oprm1 Positive_regulation of Localization of Gh1 1 0.29 0 0.89
76 INT28655 Calca Negative_regulation of Localization of Gh1 1 0.34 0 0.88
77 INT44589 Negative_regulation of Oprl1 Positive_regulation of Gh1 1 0.22 0.53 0.87
78 INT44590 Oprl1 Positive_regulation of Gh1 1 0.23 0.53 0.87
79 INT40742 Pomc Regulation of Localization of Gh1 1 0.37 0 0.86
80 INT104126 STAT3 Regulation of Phospho1 1 0.00 0.06 0.86
81 INT167947 Binding of STAT1 and Oprm1 1 0.00 0 0.86
82 INT167944 Binding of Oprm1 and Stat5a 1 0.00 0 0.85
83 INT132318 Ghrl Positive_regulation of Localization of GH1 5 0.32 4.49 0.84
84 INT105970 GH1 Regulation of Ghsr 1 0.04 1.16 0.84
85 INT183177 Binding of FGFR3 and NUDT6 1 0.06 1.08 0.84
86 INT28654 Calca Regulation of Localization of Gh1 1 0.36 0 0.84
87 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83
88 INT287494 CRP Positive_regulation of Gene_expression of CCL2 2 0.30 2.33 0.83
89 INT149561 Tgfb1 Positive_regulation of Gene_expression of CCL2 1 0.00 0 0.83
90 INT149563 Tgfb1 Positive_regulation of CCL2 1 0.00 0 0.83
91 INT5103 Gal Regulation of Localization of Gh1 1 0.33 0.08 0.82
92 INT54260 SST Regulation of GH1 1 0.18 0.06 0.81
93 INT90382 Binding of CRH and GH1 1 0.34 0.05 0.81
94 INT90381 Binding of GH1 and LAMC2 1 0.34 0.05 0.81
95 INT87489 CALCA Positive_regulation of Gene_expression of CCL2 1 0.43 0.14 0.81
96 INT73775 Binding of GH1 and GHR 4 0.35 0.68 0.8
97 INT40743 Binding of Gh1 and Pomc 1 0.22 0 0.8
98 INT54800 Grin1 Regulation of Gene_expression of Gh 1 0.01 0 0.79
99 INT105250 Cyb5b Regulation of Localization of Gh1 1 0.00 0 0.79
100 INT92793 Gh Positive_regulation of CTS 1 0.04 1.39 0.78
101 INT184116 Il10 Positive_regulation of Stat3 2 0.18 1.15 0.77
102 INT142208 Adcyap1 Positive_regulation of Transcription of Gh 1 0.05 0 0.77
103 INT149495 PNOC Negative_regulation of CCL2 1 0.11 0.16 0.77
104 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
105 INT142210 Adcyap1 Positive_regulation of Gh 1 0.05 0 0.77
106 INT118854 GNA14 Positive_regulation of Positive_regulation of STAT3 1 0.02 0.31 0.76
107 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
108 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
109 INT64067 Tp63 Negative_regulation of Localization of Gh1 1 0.08 0.07 0.76
110 INT348174 Binding of STAT3 and IL23R 1 0.40 1.9 0.76
111 INT155096 Stat3 Regulation of Mapk3 1 0.36 0.45 0.76
112 INT266408 Binding of HMGB1 and Ager 1 0.01 2.57 0.76
113 INT152429 Ghrh Positive_regulation of Localization of Gh 4 0.37 0.56 0.75
114 INT73776 Regulation of Binding of GH1 and GHR 2 0.26 0.16 0.75
115 INT222528 Abat Positive_regulation of Gene_expression of Gh1 1 0.01 0 0.75
116 INT54802 SST Negative_regulation of Localization of Gh 1 0.01 0 0.75
117 INT54801 SST Negative_regulation of Positive_regulation of Gh 1 0.01 0 0.75
118 INT258644 Binding of CCL2 and CCL5 1 0.36 1.6 0.74
119 INT258643 Positive_regulation of Binding of CCL2 and CCL5 1 0.49 1.61 0.74
120 INT17528 Prl Regulation of Gh 2 0.28 1.28 0.73
121 INT16894 Regulation of GHRH Regulation of GH1 2 0.37 0 0.72
122 INT14196 Glra2 Positive_regulation of Localization of Gh1 1 0.06 0 0.71
123 INT31307 Ghrh Regulation of Gh1 3 0.27 1.36 0.7
124 INT30125 Binding of Gh and Ghrh 2 0.06 0.36 0.7
125 INT120017 CCL2 Positive_regulation of CCL3 1 0.01 0.99 0.7
126 INT778 Tf Positive_regulation of Gh1 1 0.14 0 0.7
127 INT784 Prss12 Positive_regulation of Gh1 1 0.06 0 0.7
128 INT20688 Adra2a Regulation of Localization of Gh1 1 0.26 0.37 0.7
129 INT120020 VEGFA Positive_regulation of CCL2 1 0.00 1 0.7
130 INT120035 CCL2 Positive_regulation of Prap1 1 0.00 0.99 0.7
131 INT30409 Negative_regulation of Negative_regulation of Positive_regulation of Gh1 1 0.02 0.1 0.7
132 INT329957 Binding of STAT4 and HEPACAM 1 0.03 1.41 0.7
133 INT30408 Negative_regulation of Negative_regulation of Gh1 1 0.02 0.1 0.7
134 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69
135 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69
136 INT89009 Lep Positive_regulation of Cck 2 0.67 0.43 0.69
137 INT130717 Binding of OPRM1 and Positive_regulation of Localization of CCL2 1 0.00 0.72 0.68
138 INT47264 Abat Regulation of Localization of Gh1 1 0.14 0 0.67
139 INT40471 GH1 Positive_regulation of POMC 1 0.25 0 0.67
140 INT40470 GH1 Positive_regulation of GHRH 1 0.06 0 0.67
141 INT222552 Abat Regulation of Gene_expression of Gh1 1 0.00 0 0.67
142 INT31260 Sst Negative_regulation of Gh1 2 0.11 0 0.66
143 INT103905 Gh Positive_regulation of Positive_regulation of Crh 1 0.08 0.9 0.66
144 INT116441 IL1B Positive_regulation of Gene_expression of CCL2 2 0.04 0.62 0.65
145 INT153750 Binding of CCL2 and Crp 1 0.02 1.8 0.65
146 INT45369 IGF1 Regulation of GH1 1 0.04 1.12 0.65
147 INT153751 Regulation of Binding of CCL2 and Crp 1 0.03 1.8 0.65
148 INT126614 Ppyr1 Negative_regulation of Phosphorylation of Stat5a 1 0.27 0.1 0.64
149 INT254199 Il10 Positive_regulation of Gene_expression of Socs3 2 0.06 0.75 0.63
150 INT142209 Adcyap1 Positive_regulation of Gene_expression of Gh 1 0.05 0 0.63
151 INT30502 Negative_regulation of OPRM1 Negative_regulation of Gh 1 0.00 0 0.63
152 INT174860 VEGFA Positive_regulation of Localization of CCL2 1 0.21 1.68 0.63
153 INT3617 Trh Regulation of Localization of Gh1 3 0.65 0.55 0.62
154 INT252772 ELANE Regulation of Gene_expression of CCL2 1 0.05 2.16 0.62
155 INT252826 ROS1 Regulation of Gene_expression of CCL2 1 0.20 2.17 0.62
156 INT15731 SST Regulation of Gh 1 0.04 0 0.62
157 INT61507 Ghrhr Positive_regulation of Localization of Gh1 1 0.41 0 0.61
158 INT126615 Binding of Oprd1 and Stat5a 1 0.28 0.07 0.61
159 INT177979 Binding of STAT3 and FOXI2 1 0.00 1.83 0.61
160 INT56520 DDX21 Positive_regulation of Localization of Gh 1 0.11 0.16 0.6
161 INT56391 Pomc Negative_regulation of Localization of Gh1 1 0.26 0 0.59
162 INT43692 Cyp3a23/3a1 Negative_regulation of Gh1 1 0.04 0 0.59
163 INT30462 Gnrhr Positive_regulation of Localization of Gh1 2 0.21 0.08 0.58
164 INT144864 Htr2b Positive_regulation of Localization of Gh1 1 0.48 0 0.58
165 INT176470 TNF Positive_regulation of Gene_expression of CCL2 1 0.15 0.62 0.58
166 INT184100 Il6 Positive_regulation of Stat1 1 0.16 0.68 0.58
167 INT350699 Binding of Casp8 and Stat3 1 0.04 1.81 0.58
168 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
169 INT349083 Binding of Lep and Rtn1 1 0.09 1.68 0.57
170 INT147201 Binding of CCL2 and Hsp70-2os 1 0.00 0.76 0.57
171 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
172 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56
173 INT192971 Positive_regulation of Il6 Positive_regulation of Localization of Stat3 1 0.03 0.86 0.56
174 INT69566 Positive_regulation of Ghrh Regulation of Gh 1 0.04 1.66 0.55
175 INT266381 Positive_regulation of Ager Positive_regulation of Nfkb1 1 0.00 0.77 0.55
176 INT32478 Gh1 Regulation of Gene_expression of Ghrh 1 0.28 0 0.55
177 INT316546 Binding of GH1 and SST 2 0.03 0.55 0.54
178 INT84067 IGFBP1 Regulation of GH1 1 0.02 1.18 0.54
179 INT266376 Binding of Ager and Itgam 1 0.00 2.31 0.54
180 INT29252 Regulation of INS Positive_regulation of GH1 1 0.26 0.08 0.54
181 INT142206 Negative_regulation of Adcyap1 Positive_regulation of Gh 1 0.04 0 0.54
182 INT291386 Cntf Regulation of Gene_expression of Gria2 1 0.11 0.13 0.53
183 INT29253 INS Positive_regulation of GH1 1 0.44 0.08 0.53
184 INT33513 GH1 Positive_regulation of PRL 1 0.30 0 0.53
185 INT49696 Trh Regulation of GH1 2 0.02 0.22 0.52
186 INT8438 Cntf Regulation of TAC1 1 0.20 0.18 0.52
187 INT241247 Binding of Pkd2 and Trpv4 1 0.54 1.22 0.52
188 INT8439 Cntf Regulation of VIP 1 0.20 0.18 0.52
189 INT184130 Epo Positive_regulation of Stat5a 1 0.31 0.26 0.52
190 INT8440 Cntf Regulation of LIF 1 0.33 0.18 0.52
191 INT105971 GH1 Regulation of Ghrl 1 0.03 0.75 0.52
192 INT24869 GAL Regulation of Localization of Gh 1 0.19 0.4 0.51
193 INT32479 Gh1 Negative_regulation of Dbi 1 0.01 0 0.51
194 INT24205 Gh1 Negative_regulation of Gal 1 0.34 0 0.51
195 INT184096 Il7 Positive_regulation of Stat5a 1 0.07 0.26 0.51
196 INT121822 Binding of STAT3 and Olr1583 1 0.00 0.21 0.51
197 INT121821 Binding of STAT1 and Olr1583 1 0.00 0.21 0.51
198 INT184132 Il2 Positive_regulation of Stat5a 1 0.09 0.26 0.51
199 INT56671 Negative_regulation of Ghrh Positive_regulation of Gh1 1 0.40 0 0.49
200 INT140067 GH1 Positive_regulation of Ghsr 1 0.00 0.23 0.49

Single Events

The table below shows the top 100 pain related interactions that have been reported for JAK-STAT cascade. They are ordered first by their pain relevance and then by number of times they were reported in JAK-STAT cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT876 Localization of Gh1 843 0.80 67.75 340.82
2 INT1893 Localization of Gh 1041 0.79 340.23 256.58
3 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02
4 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18
5 INT880 Positive_regulation of Localization of Gh1 304 0.70 14.79 150.23
6 INT252 Localization of GH1 529 0.80 227.4 122.05
7 INT1530 Regulation of Gh 382 0.61 115.96 112.47
8 INT874 Positive_regulation of Gh1 244 0.70 27.17 97.98
9 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5
10 INT875 Regulation of Localization of Gh1 166 0.62 12.87 84.97
11 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91
12 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16
13 INT881 Negative_regulation of Localization of Gh1 164 0.58 15.1 75.28
14 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71
15 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85
16 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45
17 INT1782 Regulation of Gh1 125 0.62 22 55.74
18 INT1781 Negative_regulation of Gh1 127 0.59 16.94 51.77
19 INT921 Regulation of GH1 172 0.60 52.88 51.04
20 INT873 Gene_expression of Gh1 130 0.76 26.15 46.75
21 INT531 Gene_expression of GH1 376 0.75 193.45 46.24
22 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22
23 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56
24 INT255 Regulation of Localization of GH1 89 0.62 18.71 35.3
25 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92
26 INT65698 Localization of CCL2 118 0.81 77.54 32.69
27 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39
28 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76
29 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15
30 INT13454 Positive_regulation of Positive_regulation of Gh 49 0.68 14.53 18.49
31 INT66857 Regulation of CCL2 39 0.53 28.55 18.35
32 INT55880 Negative_regulation of Gene_expression of CCL2 49 0.59 22.37 18.09
33 INT55878 Regulation of Gene_expression of CCL2 34 0.62 15.71 17.97
34 INT107454 Positive_regulation of Stat3 43 0.68 19.63 17.69
35 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96
36 INT139830 Gene_expression of AGER 47 0.75 41.71 16.53
37 INT65659 Positive_regulation of STAT3 132 0.70 69.56 15.95
38 INT4242 Negative_regulation of Positive_regulation of Gh1 26 0.58 1.47 15.75
39 INT142464 Gene_expression of Socs3 58 0.77 52.04 15.34
40 INT129584 Positive_regulation of Stat3 97 0.68 87.07 14.86
41 INT107585 Gene_expression of CCR2 35 0.71 26.44 14.75
42 INT4298 Positive_regulation of Positive_regulation of Gh1 30 0.50 1.79 13.32
43 INT9678 Positive_regulation of Positive_regulation of GH1 32 0.68 8.14 12.97
44 INT107875 Phosphorylation of Stat3 49 0.80 13.18 12.66
45 INT73641 Regulation of Lep 45 0.62 26.2 12.59
46 INT96850 Negative_regulation of CCL2 42 0.59 24.89 12.55
47 INT82079 Positive_regulation of Lep 79 0.70 40 11.07
48 INT7411 Localization of FGFR3 40 0.78 4.77 10.24
49 INT83450 Positive_regulation of Localization of CCL2 28 0.70 22.14 9.83
50 INT114874 Gene_expression of Stat3 78 0.76 53.99 9.49
51 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38
52 INT11510 Negative_regulation of Positive_regulation of Gh 28 0.52 12.71 9.16
53 INT82082 Localization of Lep 63 0.81 26.41 8.56
54 INT224366 Gene_expression of Ager 111 0.77 125.37 8.49
55 INT91370 Phosphorylation of STAT3 123 0.82 49.25 8.42
56 INT8423 Gene_expression of Cntf 29 0.69 11.69 8.4
57 INT12292 Negative_regulation of Positive_regulation of GH1 22 0.58 5.02 8.28
58 INT142462 Positive_regulation of Gene_expression of Socs3 23 0.68 23.27 8.27
59 INT114873 Phosphorylation of Stat3 63 0.82 30.19 8.23
60 INT1499 Negative_regulation of Gene_expression of Gh 58 0.42 25.17 7.86
61 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8
62 INT184281 Binding of AGER 25 0.37 23.06 7.32
63 INT4299 Positive_regulation of Gene_expression of Gh1 27 0.50 5.24 7.31
64 INT138922 Positive_regulation of Stat1 57 0.69 28.35 7.2
65 INT878 Regulation of Gene_expression of Gh1 13 0.43 1.13 6.98
66 INT81493 Transcription of CCL2 20 0.65 13.63 6.78
67 INT104909 Binding of Pias1 11 0.37 3.67 6.72
68 INT120895 Binding of CCL2 22 0.37 15.86 6.55
69 INT28861 Binding of Gh 61 0.46 25.61 6.38
70 INT129918 Positive_regulation of Phosphorylation of Stat3 17 0.63 5.42 6.28
71 INT53871 Gene_expression of Socs1 32 0.71 22.83 6.21
72 INT163756 Phosphorylation of Stat1 45 0.82 14.51 6.11
73 INT9683 Binding of GH1 57 0.47 21.14 5.99
74 INT93684 Gene_expression of STAT3 66 0.78 34.42 5.94
75 INT10843 Regulation of Regulation of Gh 14 0.22 5.56 5.93
76 INT138915 Gene_expression of Stat1 144 0.77 69.53 5.85
77 INT3614 Negative_regulation of Gene_expression of Gh1 16 0.42 6.8 5.74
78 INT42378 Positive_regulation of Socs3 21 0.67 15.81 5.71
79 INT9895 Binding of GHR 18 0.36 4.8 5.65
80 INT118870 Positive_regulation of STAT1 36 0.67 26.18 5.46
81 INT13735 Negative_regulation of Regulation of GH1 14 0.42 4.35 5.39
82 INT4611 Transcription of Gh1 12 0.68 1.04 4.97
83 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
84 INT97878 Positive_regulation of Pias1 6 0.50 2.73 4.65
85 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61
86 INT114871 Positive_regulation of Phosphorylation of Stat3 20 0.69 12.34 4.6
87 INT96851 Negative_regulation of Localization of CCL2 14 0.53 5.98 4.57
88 INT160565 Gene_expression of Il23r 6 0.56 10.01 4.51
89 INT97391 Binding of Lep 18 0.48 8.97 4.47
90 INT126608 Binding of Stat5a 7 0.48 0.46 4.38
91 INT16220 Negative_regulation of Regulation of Gh 13 0.42 3.59 4.33
92 INT10842 Transcription of Gh 18 0.64 2.94 4.13
93 INT95512 Transcription of Ghr 24 0.69 3.1 4.12
94 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08
95 INT97392 Gene_expression of Stat3 27 0.65 14.21 4.06
96 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
97 INT19104 Regulation of Gene_expression of Gh 24 0.40 8.42 3.88
98 INT224369 Binding of Ager 43 0.42 40.57 3.86
99 INT11605 Regulation of Positive_regulation of Gh 10 0.45 2.08 3.85
100 INT96071 Localization of PIAS1 6 0.71 4.44 3.79
101 INT73602 Positive_regulation of Ager 35 0.69 30.66 3.74
102 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68
103 INT121818 Binding of STAT3 25 0.47 11.16 3.67
104 INT7365 Binding of Gh1 17 0.37 2.83 3.54
105 INT82077 Positive_regulation of Gene_expression of Lep 32 0.70 17.9 3.5
106 INT184270 Negative_regulation of AGER 8 0.32 10.48 3.45
107 INT8481 Regulation of PIAS1 4 0.45 0.47 3.44
108 INT20179 Positive_regulation of Regulation of Gh 12 0.54 3.99 3.42
109 INT18407 Regulation of Regulation of GH1 6 0.44 0.14 3.37
110 INT7408 Negative_regulation of FGFR3 12 0.43 2.38 3.33
111 INT184060 Negative_regulation of Stat1 28 0.58 17.44 3.19
112 INT81458 Positive_regulation of Cntf 11 0.47 4.18 3.18
113 INT89986 Gene_expression of Il6st 5 0.56 2.35 3.15
114 INT158630 Positive_regulation of Positive_regulation of Stat3 16 0.49 14.75 3.08
115 INT120067 Positive_regulation of Gene_expression of CCR2 10 0.46 5.13 3.02
116 INT13272 Regulation of Positive_regulation of Gh1 4 0.44 0.35 3.02
117 INT97393 Localization of Stat3 11 0.75 7.33 3.01
118 INT184286 Regulation of AGER 1 0.46 6.7 3
119 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97
120 INT7409 Negative_regulation of Localization of FGFR3 12 0.37 2.24 2.92
121 INT114878 Positive_regulation of Gene_expression of Stat3 15 0.49 10.81 2.91
122 INT94327 Phosphorylation of Stat1 9 0.80 2.06 2.8
123 INT53733 Positive_regulation of FGFR3 6 0.45 1.32 2.76
124 INT919 Regulation of Positive_regulation of GH1 7 0.47 1.09 2.75
125 INT184005 Negative_regulation of Gene_expression of Socs3 6 0.48 8.76 2.74
126 INT53906 Positive_regulation of Negative_regulation of Gh 9 0.50 6.72 2.73
127 INT119839 Gene_expression of STAT1 17 0.75 8.36 2.7
128 INT172186 Gene_expression of IL6ST 20 0.75 11.63 2.67
129 INT142465 Negative_regulation of Socs3 8 0.48 8.31 2.62
130 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
131 INT89929 Positive_regulation of Positive_regulation of STAT3 22 0.65 9.21 2.54
132 INT126610 Phosphorylation of Stat5a 5 0.82 0.8 2.52
133 INT129917 Negative_regulation of Phosphorylation of Stat3 6 0.41 0.85 2.51
134 INT184280 Positive_regulation of AGER 8 0.52 9.05 2.43
135 INT113339 Binding of JAK2 6 0.40 5.31 2.4
136 INT22019 Regulation of GHR 9 0.62 2.56 2.39
137 INT140993 Negative_regulation of Positive_regulation of Stat3 6 0.38 3.39 2.39
138 INT103487 Positive_regulation of Positive_regulation of Lep 9 0.67 4.08 2.38
139 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
140 INT7410 Positive_regulation of Localization of FGFR3 9 0.45 1.97 2.36
141 INT20410 Regulation of Regulation of Gh1 5 0.30 0.66 2.36
142 INT16286 Positive_regulation of GHR 8 0.60 4.04 2.31
143 INT67352 Transcription of Ghr 8 0.61 1.55 2.3
144 INT178193 Negative_regulation of Stat3 25 0.58 17.82 2.27
145 INT36314 Gene_expression of FGFR3 11 0.73 6.21 2.23
146 INT96070 Negative_regulation of PIAS1 3 0.35 1.08 2.23
147 INT184054 Negative_regulation of Gene_expression of Socs1 7 0.53 9.18 2.22
148 INT115193 Positive_regulation of Phosphorylation of STAT3 30 0.64 11.37 2.2
149 INT97876 Gene_expression of Pias1 4 0.59 1.62 2.18
150 INT4610 Negative_regulation of Transcription of Gh1 4 0.42 0.51 2.17
151 INT113906 Regulation of Positive_regulation of CCL2 4 0.27 3.2 2.17
152 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16
153 INT82081 Regulation of Gene_expression of Lep 11 0.53 7.78 2.12
154 INT228442 Localization of Cntf 8 0.63 4.2 2.12
155 INT286801 Positive_regulation of Gene_expression of Cntf 4 0.62 3.01 2.12
156 INT184284 Regulation of Gene_expression of AGER 1 0.34 4.95 2.11
157 INT95510 Regulation of Ghr 1 0.45 0.21 2.07
158 INT226443 Binding of STAT4 3 0.45 3.81 2.06
159 INT140268 Negative_regulation of Positive_regulation of Stat3 9 0.47 7.59 2.05
160 INT113907 Regulation of Localization of CCL2 5 0.62 2.46 2.05
161 INT140991 Negative_regulation of Stat3 15 0.53 7.55 2.04
162 INT83392 Transcription of Lep 6 0.54 5.07 2.04
163 INT4643 Negative_regulation of GHR 10 0.45 3.01 2
164 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
165 INT100490 Negative_regulation of Positive_regulation of CCL2 6 0.23 1.48 1.96
166 INT142461 Positive_regulation of Positive_regulation of Stat1 7 0.54 5.06 1.94
167 INT57431 Binding of PIAS1 4 0.30 4.35 1.94
168 INT101243 Regulation of STAT3 12 0.62 9.98 1.92
169 INT288630 Gene_expression of Cntf 6 0.75 3.99 1.89
170 INT184042 Negative_regulation of Socs1 9 0.46 8.1 1.88
171 INT151039 Binding of Il23r 8 0.42 3.01 1.86
172 INT148326 Gene_expression of Pkd1 7 0.76 5.38 1.85
173 INT67980 Positive_regulation of Positive_regulation of CCL2 7 0.49 5.89 1.85
174 INT41660 Regulation of IL31RA 2 0.45 1.46 1.81
175 INT1780 Regulation of Negative_regulation of Gh1 3 0.49 0.09 1.8
176 INT126609 Positive_regulation of Phosphorylation of Stat5a 1 0.69 0.26 1.79
177 INT82083 Negative_regulation of Gene_expression of Lep 12 0.56 8.07 1.75
178 INT184068 Positive_regulation of Socs1 7 0.51 4.03 1.73
179 INT119837 Positive_regulation of Gene_expression of STAT1 6 0.49 3.66 1.73
180 INT165617 Localization of STAT3 28 0.78 9.04 1.72
181 INT8422 Binding of Cntf 8 0.37 4.54 1.72
182 INT138917 Positive_regulation of Gene_expression of Stat1 63 0.69 36.76 1.71
183 INT192965 Localization of Stat3 15 0.74 7.05 1.68
184 INT75316 Gene_expression of Ghr 6 0.78 1.24 1.68
185 INT8421 Regulation of Cntf 6 0.44 1.46 1.67
186 INT184273 Localization of AGER 1 0.60 3.59 1.67
187 INT45719 Positive_regulation of Transcription of Gh 5 0.47 0.68 1.66
188 INT254250 Regulation of Socs1 5 0.06 3.04 1.66
189 INT70595 Regulation of Pias1 1 0.53 0.34 1.66
190 INT113340 Phosphorylation of JAK2 17 0.78 5.69 1.6
191 INT186309 Binding of Stat1 18 0.48 5.31 1.58
192 INT140089 Positive_regulation of Stat1 5 0.68 3.42 1.58
193 INT8480 Gene_expression of PIAS1 3 0.78 1.73 1.57
194 INT184052 Localization of Socs1 3 0.59 4.07 1.54
195 INT253403 Positive_regulation of Il6st 2 0.28 2.07 1.54
196 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
197 INT28300 Gene_expression of GHR 10 0.78 4.29 1.5
198 INT133422 Binding of IL6ST 10 0.40 4.9 1.49
199 INT186064 Phosphorylation of STAT1 19 0.59 7.14 1.48
200 INT184032 Regulation of Socs3 6 0.37 4.08 1.48
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