GO:0007264

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Name small GTPase mediated signal transduction
Categary Process
Go Slim No
Go Link GO:0007264
Unique Molecular Interactions 976
Total Molecular Interactions 1322
Total Single Events 9065
Pain Genes Associated 118

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for small GTPase mediated signal transduction. They are ordered first by their pain relevance and then by number of times they were reported for small GTPase mediated signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1
2 INT269444 Binding of RAB5A and HHIP 1 0.04 0 5.79
3 INT134284 Binding of OPRM1 and PLD2 1 0.52 0 3.72
4 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81
5 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
6 INT87267 Binding of BMP8B and KRIT1 1 0.06 0.16 2.69
7 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
8 INT96465 Pnoc Positive_regulation of GEM 1 0.01 0.74 2.39
9 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
10 INT212301 NGF Regulation of Gene_expression of TRPV1 1 0.23 2.37 2.13
11 INT271408 NGF Positive_regulation of Gene_expression of CALCA 1 0.09 4.89 1.88
12 INT185097 NGF Regulation of Gene_expression of NAV1 1 0.61 0.81 1.85
13 INT136273 NGF Regulation of Gene_expression of BDNF 2 0.41 1.14 1.78
14 INT86997 Binding of HIVEP1 and NGF 2 0.03 1.75 1.73
15 INT145098 NGF Positive_regulation of BDNF 1 0.66 1.33 1.67
16 INT108066 Binding of NTRK1 and Ngf 3 0.33 2.56 1.66
17 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62
18 INT266768 NGF Positive_regulation of Localization of SFTPA1 1 0.01 1.65 1.6
19 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
20 INT240057 Binding of RHOB and NME8 1 0.41 4.11 1.5
21 INT159657 Binding of INSRR and NGF 3 0.00 1.65 1.48
22 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48
23 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48
24 INT266771 Binding of NGF and GOPC 1 0.05 3.23 1.43
25 INT169801 Binding of Adrbk1 and Rapgef3 1 0.34 1.04 1.43
26 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
27 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39
28 INT118980 NTRK1 Positive_regulation of NGF 1 0.56 1.45 1.39
29 INT87266 Negative_regulation of Binding of BMP8B and KRIT1 1 0.05 0.07 1.37
30 INT250934 Binding of BDNF and NGF 3 0.39 0.62 1.34
31 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
32 INT181492 NGF Regulation of TRPV1 1 0.21 0.93 1.31
33 INT112961 NGF Positive_regulation of ICAM1 1 0.40 0.96 1.28
34 INT162165 WDTC1 Positive_regulation of PLD2 1 0.50 0 1.25
35 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
36 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
37 INT108067 Negative_regulation of Binding of NTRK1 and Ngf 1 0.06 2.38 1.2
38 INT169802 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Rapgef3 1 0.44 0.75 1.19
39 INT116730 Rac1 Regulation of Localization of Calca 1 0.13 1.32 1.19
40 INT98908 Binding of NTRK1 and PKLR 1 0.41 1.95 1.18
41 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
42 INT98906 Positive_regulation of Binding of NTRK1 and PKLR 1 0.56 1.95 1.18
43 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
44 INT111221 MMEL1 Negative_regulation of HMOX1 1 0.01 1 1.16
45 INT231769 TNF Negative_regulation of Gene_expression of HMOX1 1 0.26 4.75 1.15
46 INT160540 Binding of NGF and PSIP1 2 0.29 1.43 1.12
47 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
48 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
49 INT12684 Binding of Bcar3 and Trim13 1 0.03 0 1.08
50 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
51 INT181494 TRPV3 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
52 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
53 INT269443 Positive_regulation of Binding of RAB5A and HHIP 1 0.04 0 1.06
54 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
55 INT267886 Arl10 Positive_regulation of Insrr 1 0.00 0.07 0.98
56 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
57 INT127672 Binding of NGFR and NTRK1 1 0.17 2.28 0.97
58 INT166790 HRAS Negative_regulation of Gene_expression of PTGER1 1 0.01 1.46 0.95
59 INT73466 PTPLA Positive_regulation of Transcription of Hras1 1 0.21 0.98 0.95
60 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
61 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
62 INT271409 NGF Positive_regulation of TRPV1 1 0.08 2.45 0.94
63 INT271410 NGF Positive_regulation of Gene_expression of TRPV1 1 0.07 2.45 0.94
64 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
65 INT127673 NGF Regulation of Gene_expression of NTRK1 1 0.48 2.12 0.92
66 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
67 INT147474 Nfe2l2 Positive_regulation of Hmox1 1 0.43 0.38 0.9
68 INT53152 Rac1 Regulation of Scg2 1 0.03 0 0.9
69 INT121702 HRAS Negative_regulation of Positive_regulation of MMP1 1 0.06 0.2 0.9
70 INT121701 HRAS Negative_regulation of MMP1 1 0.06 0.2 0.89
71 INT121704 HRAS Negative_regulation of MMP3 1 0.06 0.19 0.89
72 INT53155 Rac1 Positive_regulation of Gene_expression of Calca 1 0.06 0 0.89
73 INT121699 HRAS Negative_regulation of Gene_expression of MMP1 1 0.06 0.19 0.88
74 INT165540 NGF Positive_regulation of GRIN1 1 0.07 0.17 0.88
75 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
76 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
77 INT125234 Positive_regulation of Binding of BCR and CD40LG 1 0.31 0.76 0.86
78 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 0.02 0.05 0.85
79 INT114323 Binding of ADCY6 and RAF1 1 0.02 0.05 0.85
80 INT125233 Binding of BCR and CD40LG 1 0.23 0.75 0.85
81 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
82 INT74383 Sst Positive_regulation of GEM 1 0.01 0.09 0.82
83 INT269455 Binding of RAB5A and GOPC 1 0.08 0 0.82
84 INT74382 Negative_regulation of Sst Positive_regulation of GEM 1 0.00 0.09 0.82
85 INT201241 Positive_regulation of GDI2 Positive_regulation of Regulation of AGFG1 1 0.01 0 0.82
86 INT74384 Regulation of Sst Positive_regulation of GEM 1 0.00 0.09 0.82
87 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
88 INT220056 Binding of NTF3 and NTRK1 1 0.07 1.12 0.78
89 INT128180 Gna12 Regulation of Regulation of RHOA 1 0.00 0 0.78
90 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
91 INT81299 Ifng Positive_regulation of Gene_expression of Hmox1 1 0.52 0.75 0.76
92 INT162164 ARF6 Regulation of Positive_regulation of PLD2 1 0.60 0 0.74
93 INT43662 Negative_regulation of Binding of Chrna7 and Rac1 1 0.01 0 0.73
94 INT43663 Binding of Chrna7 and Rac2 1 0.01 0 0.72
95 INT43661 Binding of Chrna7 and Rac1 1 0.01 0 0.72
96 INT87275 KRIT1 Regulation of Oprd1 1 0.01 0.08 0.72
97 INT162162 ARF6 Regulation of OPRM1 1 0.19 0 0.71
98 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71
99 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
100 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
101 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
102 INT197115 Binding of MCF2 and RETNLB 1 0.00 1.06 0.7
103 INT99743 Olr1742 Regulation of Gene_expression of Hmox1 1 0.00 0 0.68
104 INT121966 HRAS Positive_regulation of RAC1 1 0.75 0.41 0.67
105 INT118979 NGF Positive_regulation of Phosphorylation of NTRK1 1 0.56 0.67 0.67
106 INT134286 PLD2 Regulation of Regulation of EDNRA 1 0.10 0 0.67
107 INT134287 PLD2 Regulation of Regulation of MRGPRX1 1 0.31 0 0.67
108 INT114843 NTRK1 Regulation of Gene_expression of Lgals1 1 0.06 0.84 0.66
109 INT86519 Binding of Hmox1 and Hmox2 1 0.08 0.1 0.66
110 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
111 INT103868 IFNG Positive_regulation of Hmox1 1 0.09 0.83 0.65
112 INT136815 VEGFA Positive_regulation of Positive_regulation of RHOA 1 0.44 0.06 0.65
113 INT184193 HRAS Negative_regulation of Gene_expression of IL1B 1 0.00 1.12 0.65
114 INT153796 NUBPL Negative_regulation of YWHAQ 1 0.02 0.69 0.64
115 INT99744 Calca Positive_regulation of Positive_regulation of Hmox1 1 0.48 0 0.64
116 INT103870 IRF6 Positive_regulation of Hmox1 1 0.14 0.83 0.64
117 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
118 INT330104 Binding of Sh3rf1 and Rac1 1 0.13 2.41 0.62
119 INT330101 Binding of Map3k11 and Rac1 1 0.16 2.43 0.62
120 INT247285 GLC1N Positive_regulation of Gene_expression of HRAS 1 0.02 1.3 0.61
121 INT65014 SOS1 Positive_regulation of Gene_expression of IL6 1 0.45 0.42 0.6
122 INT142993 Serpinc1 Positive_regulation of Phosphorylation of RHOA 1 0.05 0.05 0.59
123 INT164457 Ngf Positive_regulation of NTRK1 1 0.15 0.57 0.58
124 INT103165 NGF Positive_regulation of Localization of INS 1 0.05 0 0.58
125 INT164458 Negative_regulation of Ngf Positive_regulation of NTRK1 1 0.14 0.57 0.58
126 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
127 INT136682 Binding of BRAF and MC1R 2 0.49 3.16 0.57
128 INT81303 Tlr4 Positive_regulation of Gene_expression of Hmox1 1 0.03 0.55 0.56
129 INT323148 PRKCA Positive_regulation of RAF1 1 0.01 0 0.55
130 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55
131 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
132 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
133 INT323150 PRKCA Positive_regulation of Phosphorylation of RAF1 1 0.01 0 0.55
134 INT267890 Arl10 Regulation of Insrr 1 0.00 0.43 0.54
135 INT249717 Binding of NCL and MCF2L 1 0.23 0 0.54
136 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
137 INT85125 IL3 Positive_regulation of MAPK1 1 0.30 0.81 0.53
138 INT270044 Il10 Positive_regulation of Positive_regulation of Hmox1 1 0.20 1.59 0.53
139 INT69343 Binding of NTRK1 and Igh-6 1 0.02 0.69 0.53
140 INT269449 Positive_regulation of Binding of RAB5A and GOPC 1 0.11 0 0.53
141 INT85121 CSF2 Positive_regulation of MAPK1 1 0.07 0.8 0.53
142 INT85115 IL5 Positive_regulation of MAPK1 1 0.14 0.81 0.53
143 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
144 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
145 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
146 INT201939 CXCL10 Positive_regulation of MAPK1 1 0.11 0.72 0.52
147 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
148 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
149 INT122872 SEMA6A Positive_regulation of MAPK1 1 0.56 0 0.52
150 INT97949 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of CDC42 1 0.06 0.72 0.51
151 INT131368 MAPK1 Positive_regulation of Bcar3 1 0.00 0.37 0.51
152 INT77218 Binding of NFKBIL1 and NKIRAS2 1 0.00 0.27 0.51
153 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
154 INT7120 Nppb Positive_regulation of Localization of Rab8a 1 0.08 0 0.51
155 INT131367 MAPK3 Positive_regulation of Bcar3 1 0.00 0.37 0.51
156 INT131364 Bcar3 Positive_regulation of Il4 1 0.00 0.37 0.51
157 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
158 INT131369 MAPK1 Positive_regulation of Il4 1 0.01 0.37 0.51
159 INT97953 ST3GAL3 Positive_regulation of CDC42 1 0.09 0.7 0.5
160 INT350076 Positive_regulation of Hmox1 Negative_regulation of Gene_expression of Ptger2 1 0.02 1.29 0.5
161 INT127677 NGF Regulation of Gene_expression of NGFR 1 0.20 1.11 0.5
162 INT194676 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.34 0.5
163 INT106074 IL1B Positive_regulation of Gene_expression of A2M 1 0.03 0.75 0.49
164 INT145435 Binding of CPOX and HMOX1 1 0.01 0.42 0.49
165 INT106072 NFKB1 Positive_regulation of Gene_expression of A2M 1 0.19 0.75 0.49
166 INT131508 Gene_expression of Rac1 Positive_regulation of Trpv1 1 0.42 0.21 0.48
167 INT341428 EPO Positive_regulation of NGF 1 0.52 0.37 0.48
168 INT131503 Gene_expression of Rac1 Positive_regulation of Ngf 1 0.38 0.21 0.48
169 INT102553 HGF Positive_regulation of Phosphorylation of MAPK1 1 0.40 0.49 0.48
170 INT145434 Binding of HMOX1 and PTGS2 1 0.02 0.41 0.47
171 INT341426 EPO Regulation of NGF 1 0.51 0.5 0.47
172 INT102552 HGF Positive_regulation of MAPK3 1 0.38 0.47 0.47
173 INT148466 Ccl4 Positive_regulation of Hmox1 1 0.28 0.06 0.47
174 INT155881 Binding of CDX2 and KRAS 1 0.40 1.51 0.47
175 INT185917 Binding of AR and MAPK1 1 0.07 0.5 0.47
176 INT102555 HGF Positive_regulation of MAPK1 1 0.38 0.47 0.47
177 INT153658 PRKCA Negative_regulation of GEM 1 0.01 0.22 0.46
178 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45
179 INT95564 Positive_regulation of HRAS Positive_regulation of IL12A 1 0.03 0.7 0.45
180 INT242402 Negative_regulation of Bdkrb1 Positive_regulation of Hmox1 1 0.17 1.44 0.45
181 INT95562 HRAS Positive_regulation of IL12A 1 0.03 0.7 0.45
182 INT95563 HRAS Positive_regulation of TNF 1 0.03 0.7 0.45
183 INT103871 Negative_regulation of IRF6 Positive_regulation of Hmox1 1 0.12 0.61 0.45
184 INT148930 Rac1 Regulation of Chrna7 1 0.13 0.6 0.44
185 INT165677 NFE2L2 Negative_regulation of Positive_regulation of HMOX1 1 0.40 0.32 0.44
186 INT343846 MAPK1 Positive_regulation of FOS 1 0.04 1.29 0.44
187 INT169466 TGFB3 Positive_regulation of HRAS 1 0.03 0.89 0.43
188 INT188211 IL6 Regulation of MAPK1 1 0.16 1.13 0.43
189 INT201092 Binding of KNG1 and NGF 1 0.00 0.31 0.43
190 INT165678 NFE2L2 Negative_regulation of HMOX1 1 0.40 0.31 0.43
191 INT127676 NGF Regulation of TNFRSF1B 1 0.21 1.02 0.42
192 INT106396 DYT10 Positive_regulation of MAPK3 1 0.50 0 0.42
193 INT80824 NGF Positive_regulation of NTF3 1 0.47 0.26 0.42
194 INT346218 Positive_regulation of Kras Positive_regulation of Phosphorylation of Mdk 1 0.01 0.71 0.42
195 INT127675 NGF Regulation of NTRK1 1 0.48 1.01 0.42
196 INT127674 NGF Regulation of Gene_expression of TNFRSF1B 1 0.48 1.02 0.42
197 INT238913 MAPK3 Regulation of Positive_regulation of MAPK1 1 0.11 0.39 0.42
198 INT247287 Gene_expression of GLC1N Regulation of Gene_expression of HRAS 1 0.02 0.56 0.42
199 INT131506 Rac1 Regulation of Positive_regulation of Mapk14 1 0.19 0.39 0.42
200 INT269448 HHIP Positive_regulation of Binding of RAB5A 1 0.04 0 0.42

Single Events

The table below shows the top 100 pain related interactions that have been reported for small GTPase mediated signal transduction. They are ordered first by their pain relevance and then by number of times they were reported in small GTPase mediated signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
2 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45
3 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
4 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17
5 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18
6 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11
7 INT19396 Regulation of Rac1 66 0.53 37.41 30.01
8 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
9 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
10 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33
11 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
12 INT62373 Negative_regulation of NGF 34 0.59 25.87 22.38
13 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24
14 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78
15 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
16 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
17 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64
18 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15
19 INT20216 Localization of NGF 40 0.80 18.16 16.61
20 INT84924 Positive_regulation of Gene_expression of NGF 29 0.68 17.91 16.46
21 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
22 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1
23 INT71150 Binding of NGF 22 0.46 13.67 14.81
24 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
25 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01
26 INT27627 Binding of Rac1 41 0.41 22.88 13.68
27 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21
28 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8
29 INT146197 Positive_regulation of Rhoa 60 0.68 34.12 12.02
30 INT204112 Gene_expression of GEM 43 0.75 38.74 11.23
31 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
32 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92
33 INT85048 Regulation of NGF 19 0.62 11.61 10.5
34 INT63701 Localization of KRIT1 11 0.78 2.02 9.17
35 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
36 INT50055 Negative_regulation of Rac1 36 0.50 19.74 8.98
37 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42
38 INT1682 Negative_regulation of Rem1 28 0.37 7.38 8.4
39 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
40 INT82450 Negative_regulation of Hmox1 33 0.55 19.07 8.12
41 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
42 INT81293 Positive_regulation of Gene_expression of Hmox1 53 0.70 41.54 7.25
43 INT63373 Negative_regulation of Gene_expression of NGF 14 0.57 8.9 7.1
44 INT234813 Gene_expression of RAB5A 58 0.66 3.67 6.48
45 INT134290 Positive_regulation of PLD2 10 0.68 3.06 6.44
46 INT63374 Regulation of Gene_expression of NGF 12 0.45 5.6 6.4
47 INT71151 Regulation of NTRK1 10 0.62 6.65 6.21
48 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
49 INT48313 Binding of NTRK1 19 0.47 14.44 6.12
50 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
51 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74
52 INT69350 Gene_expression of RAC1 23 0.77 12.16 5.54
53 INT71152 Negative_regulation of NTRK1 15 0.59 10.28 5.5
54 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
55 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
56 INT152742 Positive_regulation of Localization of NGF 7 0.50 4.44 5.02
57 INT116527 Positive_regulation of Gene_expression of HMOX1 29 0.70 25.79 4.87
58 INT255981 Localization of RAB5A 3 0.68 0.88 4.76
59 INT269476 Binding of RAB5A 1 0.41 0 4.76
60 INT128178 Positive_regulation of RHOA 59 0.68 9.3 4.7
61 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55
62 INT26546 Positive_regulation of Gene_expression of Hras1 35 0.70 16.59 4.54
63 INT115805 Gene_expression of PLD2 7 0.76 12.49 4.51
64 INT96464 Positive_regulation of GEM 7 0.45 5.48 4.37
65 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28
66 INT20981 Binding of HRAS 42 0.48 24.49 4.23
67 INT34624 Negative_regulation of REM1 22 0.38 9.25 4.22
68 INT34184 Localization of FGD1 7 0.65 2.68 4.21
69 INT64338 Negative_regulation of Hmox1 16 0.56 12.72 4.2
70 INT58875 Positive_regulation of FGD1 20 0.60 3.88 4.19
71 INT105171 Phosphorylation of RAF1 11 0.74 2.33 4.19
72 INT109861 Gene_expression of Rhoa 11 0.78 5.67 4.02
73 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
74 INT80175 Positive_regulation of Gene_expression of HRAS 24 0.67 14.69 3.97
75 INT97096 Regulation of Hmox1 18 0.61 6.42 3.9
76 INT169475 Localization of HRAS 14 0.73 9.02 3.9
77 INT151684 Gene_expression of MCF2L 7 0.54 6.25 3.76
78 INT78619 Positive_regulation of RAC1 27 0.65 10.43 3.75
79 INT84925 Transcription of NGF 11 0.65 4.13 3.65
80 INT126685 Gene_expression of Rem1 30 0.65 11.21 3.61
81 INT80224 Regulation of Hmox1 19 0.32 10.53 3.52
82 INT121967 Regulation of RAC1 9 0.45 6.14 3.41
83 INT106422 Negative_regulation of Gene_expression of Rac1 4 0.43 3.97 3.41
84 INT117117 Positive_regulation of REM1 12 0.40 10.1 3.33
85 INT135773 Negative_regulation of Gene_expression of HMOX1 31 0.53 28.31 3.32
86 INT119421 Negative_regulation of RAF1 10 0.41 6.94 3.31
87 INT102634 Transcription of Hmox1 22 0.62 4.5 3.3
88 INT146194 Negative_regulation of Rhoa 21 0.42 11.05 3.22
89 INT58475 Localization of Rac1 12 0.75 5.94 3.2
90 INT28166 Positive_regulation of Rem1 8 0.40 7.96 3.19
91 INT115806 Positive_regulation of Gene_expression of PLD2 5 0.57 7.12 3.11
92 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
93 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
94 INT128179 Gene_expression of RHOA 7 0.64 2.48 3.01
95 INT93109 Phosphorylation of NTRK1 5 0.80 3.22 2.99
96 INT146191 Gene_expression of Rhoa 32 0.67 17.63 2.92
97 INT61714 Binding of FGD1 12 0.35 7.72 2.91
98 INT158083 Gene_expression of FGD1 24 0.67 6.82 2.83
99 INT127904 Negative_regulation of Gene_expression of Hmox1 11 0.42 9.54 2.8
100 INT10141 Gene_expression of A2M 11 0.35 9.37 2.75
101 INT234825 Positive_regulation of Gene_expression of RAB5A 16 0.59 1.15 2.71
102 INT119518 Positive_regulation of Gene_expression of NTRK1 5 0.67 3.47 2.66
103 INT62683 Negative_regulation of HRAS 19 0.57 7.93 2.65
104 INT204116 Regulation of Gene_expression of GEM 8 0.29 8.66 2.6
105 INT204110 Positive_regulation of Gene_expression of GEM 11 0.67 8.85 2.57
106 INT169798 Positive_regulation of Rapgef3 1 0.45 1.7 2.56
107 INT699 Positive_regulation of A2M 16 0.66 10.49 2.5
108 INT262339 Positive_regulation of TRIP10 2 0.26 2.07 2.5
109 INT140363 Negative_regulation of Rhoa 7 0.58 2.49 2.47
110 INT81291 Regulation of Gene_expression of Hmox1 11 0.60 8.78 2.46
111 INT44880 Gene_expression of REM1 21 0.30 5.3 2.43
112 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
113 INT128174 Positive_regulation of Gene_expression of RHOA 7 0.36 1.5 2.36
114 INT249718 Binding of MCF2L 6 0.16 3.52 2.36
115 INT65928 Positive_regulation of Gene_expression of Rac1 12 0.42 3.34 2.33
116 INT114327 Positive_regulation of RAF1 26 0.51 20.87 2.32
117 INT186116 Regulation of Gene_expression of MAPK1 9 0.44 5.85 2.32
118 INT146196 Localization of Rhoa 6 0.78 4.68 2.3
119 INT131850 Gene_expression of RHOC 17 0.72 29.06 2.28
120 INT146192 Positive_regulation of Positive_regulation of Rhoa 8 0.60 8.15 2.17
121 INT23352 Negative_regulation of A2M 10 0.33 8.35 2.16
122 INT70987 Binding of RAC1 14 0.37 12.14 2.13
123 INT63375 Positive_regulation of Positive_regulation of NGF 2 0.48 1.17 2.08
124 INT69196 Positive_regulation of Rap1a 2 0.29 1.18 2.06
125 INT109906 Localization of MAPK1 12 0.54 1.68 2.01
126 INT83709 Negative_regulation of Gene_expression of MAPK1 12 0.41 6.57 2.01
127 INT66941 Localization of NTRK1 8 0.78 5.89 1.96
128 INT7116 Localization of Rab8a 10 0.70 1.2 1.95
129 INT76993 Regulation of HRAS 8 0.60 7.81 1.95
130 INT99970 Regulation of Binding of NGF 2 0.27 2.35 1.93
131 INT117980 Regulation of Rac1 10 0.45 3.72 1.88
132 INT126626 Positive_regulation of Rhoa 14 0.69 4.43 1.87
133 INT146193 Negative_regulation of Positive_regulation of Rhoa 3 0.42 3 1.84
134 INT240058 Gene_expression of RHOB 2 0.55 4.29 1.84
135 INT85348 Localization of RHOA 12 0.59 4.81 1.83
136 INT149441 Positive_regulation of MCF2L 5 0.61 3.96 1.82
137 INT118683 Regulation of Phosphorylation of MAPK3 3 0.44 2.92 1.82
138 INT48218 Gene_expression of KRIT1 16 0.75 7.59 1.8
139 INT99742 Negative_regulation of Gene_expression of Hmox1 12 0.58 9.94 1.77
140 INT59790 Binding of BCR 16 0.36 15.34 1.75
141 INT134991 Regulation of Rem1 4 0.28 3.45 1.71
142 INT234827 Positive_regulation of RAB5A 3 0.59 0.54 1.69
143 INT109975 Positive_regulation of Kras 14 0.45 12.72 1.68
144 INT254045 Gene_expression of TRIP10 4 0.29 3.04 1.67
145 INT87282 Regulation of MAPK3 9 0.60 7.61 1.65
146 INT80227 Regulation of Gene_expression of Hmox1 12 0.44 11.04 1.61
147 INT3249 Regulation of A2M 7 0.39 3.29 1.61
148 INT240059 Binding of RHOB 7 0.48 3.96 1.59
149 INT6438 Positive_regulation of RAN 6 0.42 2.09 1.59
150 INT91232 Regulation of Positive_regulation of Hmox1 5 0.45 2.43 1.55
151 INT93624 Negative_regulation of Kras 3 0.41 1.15 1.52
152 INT101859 Gene_expression of MCF2 34 0.49 19.45 1.51
153 INT37485 Regulation of RAPGEF5 10 0.44 6.64 1.51
154 INT85046 Positive_regulation of Positive_regulation of NTRK1 2 0.50 0.63 1.51
155 INT130019 Regulation of Phosphorylation of MAPK1 6 0.49 3.6 1.5
156 INT146190 Negative_regulation of Localization of Rhoa 4 0.42 1.64 1.5
157 INT103305 Positive_regulation of Positive_regulation of Hmox1 8 0.49 4.81 1.49
158 INT100420 Regulation of HMOX1 10 0.35 6.68 1.48
159 INT179550 Phosphorylation of Ywhaq 8 0.03 6.24 1.48
160 INT87272 Binding of KRIT1 4 0.47 1.2 1.48
161 INT184206 Protein_catabolism of HRAS 22 0.66 7.86 1.46
162 INT113659 Gene_expression of ABR 19 0.65 8.49 1.45
163 INT42391 Positive_regulation of BCR 7 0.49 4.93 1.44
164 INT115807 Negative_regulation of PLD2 3 0.57 0.69 1.43
165 INT169799 Binding of Rapgef3 1 0.30 1.04 1.43
166 INT47734 Positive_regulation of RAPGEF5 19 0.56 13.16 1.41
167 INT104121 Positive_regulation of MAP2K1 8 0.61 4.84 1.41
168 INT165680 Transcription of HMOX1 7 0.71 11.2 1.41
169 INT58930 Negative_regulation of RAC1 14 0.55 7.55 1.4
170 INT159303 Regulation of Negative_regulation of NGF 1 0.44 0.96 1.39
171 INT220073 Negative_regulation of Binding of NGF 1 0.23 1.1 1.39
172 INT71782 Gene_expression of MAP2K1 7 0.68 3.17 1.37
173 INT131848 Positive_regulation of Gene_expression of RHOC 9 0.64 15.43 1.36
174 INT104027 Negative_regulation of Negative_regulation of MAPK1 6 0.56 2.87 1.35
175 INT69195 Negative_regulation of Rap1a 1 0.10 0.34 1.33
176 INT92383 Gene_expression of KRAS 38 0.65 32.94 1.32
177 INT229794 Positive_regulation of RAB7A 2 0.65 11.68 1.31
178 INT108601 Negative_regulation of Gene_expression of NTRK1 2 0.41 0.28 1.31
179 INT54587 Positive_regulation of Hras1 12 0.27 5.54 1.3
180 INT85047 Positive_regulation of Negative_regulation of NTRK1 3 0.47 2.13 1.3
181 INT281406 Gene_expression of RAPGEFL1 1 0.13 7.09 1.29
182 INT127283 Regulation of Gene_expression of HMOX1 14 0.61 11.8 1.28
183 INT91320 Localization of Hmox1 8 0.81 4.06 1.28
184 INT142992 Phosphorylation of RHOA 3 0.80 0.87 1.28
185 INT128176 Regulation of RHOA 13 0.44 4.35 1.26
186 INT118682 Positive_regulation of KRIT1 4 0.67 1.25 1.24
187 INT11203 Gene_expression of BCR 30 0.75 33.49 1.22
188 INT111859 Regulation of Rhoa 3 0.61 0.23 1.22
189 INT16013 Gene_expression of Rac1 52 0.75 23.79 1.21
190 INT60060 Positive_regulation of KRAS 17 0.67 11.68 1.21
191 INT98062 Regulation of Gene_expression of Rac1 4 0.39 1.41 1.21
192 INT229791 Gene_expression of RAB7A 2 0.73 6.48 1.21
193 INT93980 Gene_expression of Rab8a 1 0.74 2.72 1.21
194 INT97955 Positive_regulation of CDC42 8 0.49 2.47 1.19
195 INT71863 Negative_regulation of YWHAQ 4 0.58 1.8 1.19
196 INT127805 Positive_regulation of Phosphorylation of RAF1 3 0.45 1.21 1.17
197 INT229792 Negative_regulation of Positive_regulation of RAB7A 1 0.40 1.49 1.17
198 INT96463 Regulation of Positive_regulation of GEM 1 0.01 0.32 1.16
199 INT115831 Transcription of Hmox1 16 0.66 5.31 1.14
200 INT98061 Negative_regulation of Binding of Rac1 3 0.43 2.28 1.13
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