GO:0007265

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Name Ras protein signal transduction
Categary Process
Go Slim No
Go Link GO:0007265
Unique Molecular Interactions 1115
Total Molecular Interactions 1521
Total Single Events 10948
Pain Genes Associated 54

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Ras protein signal transduction. They are ordered first by their pain relevance and then by number of times they were reported for Ras protein signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1
3 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
4 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81
5 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
6 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
7 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
8 INT212301 NGF Regulation of Gene_expression of TRPV1 1 0.23 2.37 2.13
9 INT271408 NGF Positive_regulation of Gene_expression of CALCA 1 0.09 4.89 1.88
10 INT185097 NGF Regulation of Gene_expression of NAV1 1 0.61 0.81 1.85
11 INT136273 NGF Regulation of Gene_expression of BDNF 2 0.41 1.14 1.78
12 INT86997 Binding of HIVEP1 and NGF 2 0.03 1.75 1.73
13 INT145098 NGF Positive_regulation of BDNF 1 0.66 1.33 1.67
14 INT108066 Binding of NTRK1 and Ngf 3 0.33 2.56 1.66
15 INT347396 RYBP Positive_regulation of Binding of Sdcbp 1 0.00 0.92 1.66
16 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
17 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62
18 INT266768 NGF Positive_regulation of Localization of SFTPA1 1 0.01 1.65 1.6
19 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
20 INT347397 RYBP Positive_regulation of Sdcbp 1 0.00 0.22 1.56
21 INT159657 Binding of INSRR and NGF 3 0.00 1.65 1.48
22 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48
23 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48
24 INT266771 Binding of NGF and GOPC 1 0.05 3.23 1.43
25 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39
26 INT118980 NTRK1 Positive_regulation of NGF 1 0.56 1.45 1.39
27 INT250934 Binding of BDNF and NGF 3 0.39 0.62 1.34
28 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34
29 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
30 INT181492 NGF Regulation of TRPV1 1 0.21 0.93 1.31
31 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29
32 INT112961 NGF Positive_regulation of ICAM1 1 0.40 0.96 1.28
33 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
34 INT139724 PROC Positive_regulation of MAPK14 1 0.00 1.57 1.25
35 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
36 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
37 INT108067 Negative_regulation of Binding of NTRK1 and Ngf 1 0.06 2.38 1.2
38 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
39 INT330379 Gene_expression of IL10 Negative_regulation of Positive_regulation of MAPK14 1 0.00 1.95 1.18
40 INT98908 Binding of NTRK1 and PKLR 1 0.41 1.95 1.18
41 INT121191 KCNMA1 Positive_regulation of Phosphorylation of MAPK1 1 0.06 0.61 1.18
42 INT98906 Positive_regulation of Binding of NTRK1 and PKLR 1 0.56 1.95 1.18
43 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17
44 INT160540 Binding of NGF and PSIP1 2 0.29 1.43 1.12
45 INT346986 Binding of SHC3 and PAG1 1 0.35 1.02 1.12
46 INT108546 BCL2L10 Regulation of MAPKAPK5 1 0.03 1.22 1.1
47 INT164378 MAPK3 Positive_regulation of Transcription of PDYN 1 0.50 0.2 1.09
48 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
49 INT164382 MAPK3 Positive_regulation of Gene_expression of Fos 1 0.75 0.2 1.08
50 INT164383 Positive_regulation of MAPK3 Positive_regulation of Gene_expression of Fos 1 0.54 0.2 1.08
51 INT181494 TRPV3 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
52 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
53 INT101067 MAP3K15 Positive_regulation of MAPK1 1 0.21 0.47 1.03
54 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
55 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
56 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
57 INT127672 Binding of NGFR and NTRK1 1 0.17 2.28 0.97
58 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
59 INT166790 HRAS Negative_regulation of Gene_expression of PTGER1 1 0.01 1.46 0.95
60 INT73466 PTPLA Positive_regulation of Transcription of Hras1 1 0.21 0.98 0.95
61 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94
62 INT144281 ACP1 Negative_regulation of Positive_regulation of MAPK1 1 0.27 0.58 0.94
63 INT271409 NGF Positive_regulation of TRPV1 1 0.08 2.45 0.94
64 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
65 INT271410 NGF Positive_regulation of Gene_expression of TRPV1 1 0.07 2.45 0.94
66 INT144285 ACP1 Negative_regulation of MAPK1 1 0.37 0.58 0.93
67 INT127673 NGF Regulation of Gene_expression of NTRK1 1 0.48 2.12 0.92
68 INT302828 Mapkapk5 Positive_regulation of Mapk1 1 0.07 1.38 0.91
69 INT343918 IgG Positive_regulation of Phosphorylation of MAPK1 1 0.01 3.57 0.91
70 INT121702 HRAS Negative_regulation of Positive_regulation of MMP1 1 0.06 0.2 0.9
71 INT121701 HRAS Negative_regulation of MMP1 1 0.06 0.2 0.89
72 INT121704 HRAS Negative_regulation of MMP3 1 0.06 0.19 0.89
73 INT92404 PSRC1 Regulation of CDKN1A 1 0.33 0.66 0.89
74 INT121699 HRAS Negative_regulation of Gene_expression of MMP1 1 0.06 0.19 0.88
75 INT165540 NGF Positive_regulation of GRIN1 1 0.07 0.17 0.88
76 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
77 INT188196 LIF Regulation of MAPK1 1 0.21 2.26 0.87
78 INT188214 OSM Regulation of MAPK1 1 0.20 2.27 0.87
79 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
80 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 0.02 0.05 0.85
81 INT114323 Binding of ADCY6 and RAF1 1 0.02 0.05 0.85
82 INT190183 MAPK1 Regulation of CDCP1 1 0.00 1.19 0.85
83 INT183175 Binding of FGF2 and NUDT6 1 0.07 1.07 0.84
84 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
85 INT347391 Positive_regulation of RYBP Positive_regulation of Sdcbp 1 0.00 0.22 0.79
86 INT347398 RYBP Positive_regulation of Positive_regulation of Sdcbp 1 0.00 0.22 0.79
87 INT302831 Binding of Creb1 and Mapkapk5 1 0.07 1.3 0.79
88 INT220056 Binding of NTF3 and NTRK1 1 0.07 1.12 0.78
89 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
90 INT346234 MAP2K6 Positive_regulation of MAPK14 1 0.44 1.65 0.77
91 INT81975 Binding of OPRL1 and RASGRP1 1 0.03 0 0.76
92 INT163830 ERBB2 Positive_regulation of MAPK1 1 0.06 1.63 0.76
93 INT133675 NPY6R Negative_regulation of SRC 1 0.17 0.75 0.74
94 INT14178 DHCR24 Positive_regulation of Localization of PDYN 1 0.05 0 0.72
95 INT14177 DHCR24 Positive_regulation of PDYN 1 0.05 0 0.71
96 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71
97 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
98 INT194685 MAPK1 Regulation of Gene_expression of IL10 1 0.06 1.18 0.7
99 INT320634 Positive_regulation of MAPK1 Regulation of PBX2 1 0.03 1.21 0.7
100 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69
101 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69
102 INT121966 HRAS Positive_regulation of RAC1 1 0.75 0.41 0.67
103 INT118979 NGF Positive_regulation of Phosphorylation of NTRK1 1 0.56 0.67 0.67
104 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
105 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66
106 INT114843 NTRK1 Regulation of Gene_expression of Lgals1 1 0.06 0.84 0.66
107 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65
108 INT27526 Binding of Sdcbp and Eda 1 0.13 0 0.65
109 INT184193 HRAS Negative_regulation of Gene_expression of IL1B 1 0.00 1.12 0.65
110 INT45369 IGF1 Regulation of GH1 1 0.04 1.12 0.65
111 INT169285 PTPLA Positive_regulation of GRAP2 1 0.03 0.15 0.63
112 INT169296 PTPLA Positive_regulation of MAPK3 1 0.10 0.15 0.63
113 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
114 INT247285 GLC1N Positive_regulation of Gene_expression of HRAS 1 0.02 1.3 0.61
115 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
116 INT166395 CDKN1A Regulation of Gene_expression of IFI27 1 0.32 0.83 0.61
117 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
118 INT166392 IFI27 Regulation of Gene_expression of CDKN1A 1 0.32 0.83 0.61
119 INT92403 PSRC1 Regulation of Positive_regulation of CDKN1A 1 0.33 0.45 0.6
120 INT65014 SOS1 Positive_regulation of Gene_expression of IL6 1 0.45 0.42 0.6
121 INT54942 Rb1 Regulation of Gab1 1 0.02 0.39 0.59
122 INT164457 Ngf Positive_regulation of NTRK1 1 0.15 0.57 0.58
123 INT103165 NGF Positive_regulation of Localization of INS 1 0.05 0 0.58
124 INT164458 Negative_regulation of Ngf Positive_regulation of NTRK1 1 0.14 0.57 0.58
125 INT115146 MAPK1 Positive_regulation of EGR1 3 0.13 2.43 0.57
126 INT192291 OR5A1 Positive_regulation of Gene_expression of IGF1 1 0.02 0.93 0.57
127 INT278694 TNF Positive_regulation of MAPK14 1 0.03 0.79 0.56
128 INT323148 PRKCA Positive_regulation of RAF1 1 0.01 0 0.55
129 INT201949 CXCL10 Positive_regulation of Phosphorylation of MAPK1 1 0.15 0.79 0.55
130 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
131 INT99486 OPRM1 Positive_regulation of MAPK3 1 0.22 0 0.55
132 INT323150 PRKCA Positive_regulation of Phosphorylation of RAF1 1 0.01 0 0.55
133 INT339532 FGF2 Positive_regulation of YWHAZ 1 0.00 1.26 0.54
134 INT323146 PRKCA Positive_regulation of MAPK1 1 0.02 0 0.54
135 INT85125 IL3 Positive_regulation of MAPK1 1 0.30 0.81 0.53
136 INT69343 Binding of NTRK1 and Igh-6 1 0.02 0.69 0.53
137 INT85121 CSF2 Positive_regulation of MAPK1 1 0.07 0.8 0.53
138 INT85115 IL5 Positive_regulation of MAPK1 1 0.14 0.81 0.53
139 INT164265 TGM7 Negative_regulation of CDK2 1 0.26 1.08 0.53
140 INT49358 Binding of DHCR24 and Pdyn 1 0.00 0 0.53
141 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53
142 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
143 INT171910 MAPK1 Positive_regulation of MAPK9 1 0.10 1.55 0.52
144 INT201939 CXCL10 Positive_regulation of MAPK1 1 0.11 0.72 0.52
145 INT171906 MAPK1 Positive_regulation of Gene_expression of MAPK14 1 0.08 1.55 0.52
146 INT142882 IGF1 Positive_regulation of Gene_expression of TRPV1 1 0.06 0.57 0.52
147 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
148 INT122872 SEMA6A Positive_regulation of MAPK1 1 0.56 0 0.52
149 INT131368 MAPK1 Positive_regulation of Bcar3 1 0.00 0.37 0.51
150 INT131371 MAPK3 Positive_regulation of Il4 1 0.02 0.37 0.51
151 INT131367 MAPK3 Positive_regulation of Bcar3 1 0.00 0.37 0.51
152 INT131370 MAPK3 Positive_regulation of Gene_expression of Il4 1 0.02 0.37 0.51
153 INT131369 MAPK1 Positive_regulation of Il4 1 0.01 0.37 0.51
154 INT127677 NGF Regulation of Gene_expression of NGFR 1 0.20 1.11 0.5
155 INT194676 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of IL10 1 0.05 0.34 0.5
156 INT341428 EPO Positive_regulation of NGF 1 0.52 0.37 0.48
157 INT102553 HGF Positive_regulation of Phosphorylation of MAPK1 1 0.40 0.49 0.48
158 INT341426 EPO Regulation of NGF 1 0.51 0.5 0.47
159 INT102552 HGF Positive_regulation of MAPK3 1 0.38 0.47 0.47
160 INT155881 Binding of CDX2 and KRAS 1 0.40 1.51 0.47
161 INT185917 Binding of AR and MAPK1 1 0.07 0.5 0.47
162 INT102555 HGF Positive_regulation of MAPK1 1 0.38 0.47 0.47
163 INT116934 OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
164 INT116933 SRC Positive_regulation of JUN 1 0.33 0.15 0.46
165 INT116937 Positive_regulation of OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
166 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45
167 INT95564 Positive_regulation of HRAS Positive_regulation of IL12A 1 0.03 0.7 0.45
168 INT95562 HRAS Positive_regulation of IL12A 1 0.03 0.7 0.45
169 INT95563 HRAS Positive_regulation of TNF 1 0.03 0.7 0.45
170 INT343846 MAPK1 Positive_regulation of FOS 1 0.04 1.29 0.44
171 INT264295 Binding of DMD and IGF1 1 0.07 1.38 0.44
172 INT169466 TGFB3 Positive_regulation of HRAS 1 0.03 0.89 0.43
173 INT189197 RASGRP1 Positive_regulation of JUN 1 0.07 1.26 0.43
174 INT188211 IL6 Regulation of MAPK1 1 0.16 1.13 0.43
175 INT278964 MAPK14 Negative_regulation of Localization of EPHB2 1 0.15 0.47 0.43
176 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
177 INT201092 Binding of KNG1 and NGF 1 0.00 0.31 0.43
178 INT127676 NGF Regulation of TNFRSF1B 1 0.21 1.02 0.42
179 INT106396 DYT10 Positive_regulation of MAPK3 1 0.50 0 0.42
180 INT80824 NGF Positive_regulation of NTF3 1 0.47 0.26 0.42
181 INT346218 Positive_regulation of Kras Positive_regulation of Phosphorylation of Mdk 1 0.01 0.71 0.42
182 INT127675 NGF Regulation of NTRK1 1 0.48 1.01 0.42
183 INT127674 NGF Regulation of Gene_expression of TNFRSF1B 1 0.48 1.02 0.42
184 INT238913 MAPK3 Regulation of Positive_regulation of MAPK1 1 0.11 0.39 0.42
185 INT247287 Gene_expression of GLC1N Regulation of Gene_expression of HRAS 1 0.02 0.56 0.42
186 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41
187 INT194722 Negative_regulation of MAPK1 Negative_regulation of Gene_expression of CRP 1 0.09 1.49 0.41
188 INT261652 Binding of MAPK1 and PSEN1 1 0.22 1.25 0.41
189 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41
190 INT261790 SHC1 Positive_regulation of Slc12a5 1 0.02 0.06 0.41
191 INT194705 Negative_regulation of MAPK1 Negative_regulation of Positive_regulation of IK 1 0.00 1.46 0.41
192 INT113474 MAPK1 Negative_regulation of TNF 1 0.13 0.23 0.4
193 INT351237 HRAS Regulation of CBL 1 0.00 0.48 0.4
194 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4
195 INT105169 RAF1 Regulation of Positive_regulation of ADCY1 1 0.12 0 0.4
196 INT302824 Mapkapk5 Positive_regulation of Phosphorylation of Hspb2 1 0.11 0.64 0.4
197 INT303650 Binding of IGF1 and SSTR1 1 0.12 2.17 0.4
198 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39
199 INT166788 HRAS Negative_regulation of Phosphorylation of NFKB1 1 0.08 0.5 0.39
200 INT124798 RAF1 Regulation of PRKCA 1 0.06 0 0.39

Single Events

The table below shows the top 100 pain related interactions that have been reported for Ras protein signal transduction. They are ordered first by their pain relevance and then by number of times they were reported in Ras protein signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
2 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45
3 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
4 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
5 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11
6 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
7 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
8 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36
9 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
10 INT71781 Phosphorylation of MAPK3 62 0.80 27.73 23.73
11 INT86534 Positive_regulation of MAPK14 81 0.62 57.81 23.62
12 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71
13 INT62373 Negative_regulation of NGF 34 0.59 25.87 22.38
14 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24
15 INT35711 Positive_regulation of Sdcbp 110 0.60 50.45 22.11
16 INT171924 Gene_expression of MAPK14 60 0.65 54.38 21.68
17 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78
18 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
19 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9
20 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3
21 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88
22 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
23 INT20216 Localization of NGF 40 0.80 18.16 16.61
24 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47
25 INT84924 Positive_regulation of Gene_expression of NGF 29 0.68 17.91 16.46
26 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
27 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42
28 INT24670 Gene_expression of FGF2 121 0.78 85.64 15.12
29 INT71150 Binding of NGF 22 0.46 13.67 14.81
30 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74
31 INT80688 Positive_regulation of Positive_regulation of MAPK1 72 0.69 39.35 14.11
32 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
33 INT35120 Gene_expression of Sdcbp 68 0.67 21.33 13.96
34 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
35 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21
36 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32
37 INT75525 Negative_regulation of Positive_regulation of MAPK1 40 0.59 25.15 11.15
38 INT85048 Regulation of NGF 19 0.62 11.61 10.5
39 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37
40 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
41 INT11729 Regulation of IGF1 71 0.61 44.58 9.71
42 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69
43 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16
44 INT34777 Localization of IGF1 82 0.80 42.68 8.62
45 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42
46 INT71785 Gene_expression of MAPK3 22 0.75 11.35 8.21
47 INT91618 Positive_regulation of Phosphorylation of MAPK3 21 0.67 7.99 7.65
48 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
49 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
50 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27
51 INT63373 Negative_regulation of Gene_expression of NGF 14 0.57 8.9 7.1
52 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
53 INT35712 Regulation of Sdcbp 19 0.23 5.3 6.58
54 INT63374 Regulation of Gene_expression of NGF 12 0.45 5.6 6.4
55 INT71151 Regulation of NTRK1 10 0.62 6.65 6.21
56 INT94197 Negative_regulation of Phosphorylation of MAPK3 13 0.57 5.51 6.18
57 INT48313 Binding of NTRK1 19 0.47 14.44 6.12
58 INT37745 Positive_regulation of Gene_expression of Sdcbp 22 0.60 5.15 6.02
59 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
60 INT130111 Regulation of Positive_regulation of MAPK1 14 0.36 11.01 5.9
61 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88
62 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56
63 INT71152 Negative_regulation of NTRK1 15 0.59 10.28 5.5
64 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47
65 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47
66 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
67 INT71779 Positive_regulation of Gene_expression of MAPK1 27 0.47 21.41 5.39
68 INT99487 Negative_regulation of MAPK3 15 0.57 7.13 5.39
69 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38
70 INT60585 Regulation of TP53 59 0.59 54.55 5.21
71 INT97905 Positive_regulation of FGF2 33 0.70 26.74 5.17
72 INT152742 Positive_regulation of Localization of NGF 7 0.50 4.44 5.02
73 INT26167 Positive_regulation of Hrasls 18 0.23 8.67 4.87
74 INT160055 Localization of CDKN1A 15 0.78 12.56 4.83
75 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
76 INT68216 Binding of NF1 40 0.48 51.24 4.59
77 INT26546 Positive_regulation of Gene_expression of Hras1 35 0.70 16.59 4.54
78 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
79 INT35122 Negative_regulation of Sdcbp 43 0.51 22.01 4.34
80 INT117920 Regulation of MAPK14 14 0.38 8.75 4.31
81 INT63113 Positive_regulation of HRAS 30 0.67 22.85 4.28
82 INT69781 Negative_regulation of FGF2 22 0.42 17.25 4.24
83 INT20981 Binding of HRAS 42 0.48 24.49 4.23
84 INT105171 Phosphorylation of RAF1 11 0.74 2.33 4.19
85 INT117921 Positive_regulation of Positive_regulation of MAPK14 9 0.44 9.93 4.18
86 INT44789 Binding of Sdcbp 10 0.36 1.65 4.01
87 INT106065 Negative_regulation of MAP2K1 27 0.57 12.69 3.97
88 INT80175 Positive_regulation of Gene_expression of HRAS 24 0.67 14.69 3.97
89 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96
90 INT169475 Localization of HRAS 14 0.73 9.02 3.9
91 INT84925 Transcription of NGF 11 0.65 4.13 3.65
92 INT53706 Positive_regulation of Kras 13 0.67 9.26 3.57
93 INT167446 Regulation of CCNA2 2 0.39 2.01 3.49
94 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33
95 INT151421 Negative_regulation of Positive_regulation of Sdcbp 11 0.30 6.61 3.32
96 INT119421 Negative_regulation of RAF1 10 0.41 6.94 3.31
97 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28
98 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21
99 INT29929 Gene_expression of Rb1 20 0.69 5.81 3.1
100 INT100688 Gene_expression of SRC 28 0.75 15.51 3.08
101 INT75505 Regulation of Gene_expression of CDKN1A 24 0.60 12.24 3.07
102 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05
103 INT71783 Positive_regulation of Gene_expression of MAPK3 9 0.59 4.59 3.05
104 INT87288 Positive_regulation of Positive_regulation of MAPK3 5 0.67 1.62 3.04
105 INT115317 Transcription of FGF2 14 0.62 12.79 3
106 INT174864 Positive_regulation of Transcription of FGF2 8 0.44 7.58 3
107 INT93109 Phosphorylation of NTRK1 5 0.80 3.22 2.99
108 INT88810 Positive_regulation of Gene_expression of FGF2 17 0.50 12.62 2.98
109 INT8103 Binding of TP53 46 0.44 40.2 2.96
110 INT16130 Binding of IGF1 67 0.48 27.43 2.95
111 INT173179 Binding of MAPK14 13 0.29 4.51 2.92
112 INT75499 Positive_regulation of Positive_regulation of CDKN1A 12 0.60 7.28 2.84
113 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
114 INT54938 Regulation of Rb1 6 0.44 4.41 2.69
115 INT119518 Positive_regulation of Gene_expression of NTRK1 5 0.67 3.47 2.66
116 INT62683 Negative_regulation of HRAS 19 0.57 7.93 2.65
117 INT176531 Gene_expression of SHC1 3 0.67 9.5 2.62
118 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48
119 INT24672 Localization of FGF2 27 0.71 14.59 2.48
120 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46
121 INT202341 Gene_expression of Mapkapk5 3 0.46 3.67 2.43
122 INT61434 Regulation of Nf1 3 0.26 1.39 2.4
123 INT111039 Gene_expression of Kras 20 0.60 15.42 2.39
124 INT110179 Negative_regulation of Phosphorylation of MAPK14 11 0.36 5.25 2.38
125 INT87284 Negative_regulation of Positive_regulation of MAPK3 7 0.41 2.65 2.38
126 INT55952 Transcription of TP53 16 0.61 12.14 2.36
127 INT114327 Positive_regulation of RAF1 26 0.51 20.87 2.32
128 INT186116 Regulation of Gene_expression of MAPK1 9 0.44 5.85 2.32
129 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31
130 INT64700 Binding of Nf1 14 0.45 15.24 2.29
131 INT219458 Negative_regulation of CCNA2 9 0.38 1.23 2.21
132 INT21611 Negative_regulation of RASGRP1 20 0.35 11.76 2.15
133 INT97898 Regulation of FGF2 8 0.60 3.85 2.09
134 INT128210 Positive_regulation of Positive_regulation of Sdcbp 6 0.08 3.88 2.08
135 INT63375 Positive_regulation of Positive_regulation of NGF 2 0.48 1.17 2.08
136 INT173647 Positive_regulation of Gene_expression of MAPK14 15 0.39 7.54 2.05
137 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04
138 INT109906 Localization of MAPK1 12 0.54 1.68 2.01
139 INT83709 Negative_regulation of Gene_expression of MAPK1 12 0.41 6.57 2.01
140 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
141 INT177841 Gene_expression of CCNA2 2 0.50 0.64 1.97
142 INT66941 Localization of NTRK1 8 0.78 5.89 1.96
143 INT76993 Regulation of HRAS 8 0.60 7.81 1.95
144 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
145 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94
146 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93
147 INT99970 Regulation of Binding of NGF 2 0.27 2.35 1.93
148 INT65855 Localization of TP53 18 0.76 17.08 1.89
149 INT23426 Regulation of ADRA2A 8 0.48 1.81 1.88
150 INT68181 Binding of Nf1 6 0.48 8.14 1.88
151 INT257755 Positive_regulation of SHC1 1 0.60 4.97 1.87
152 INT98464 Positive_regulation of Positive_regulation of SRC 10 0.67 5.71 1.86
153 INT35121 Negative_regulation of Gene_expression of Sdcbp 6 0.43 2.4 1.83
154 INT118683 Regulation of Phosphorylation of MAPK3 3 0.44 2.92 1.82
155 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
156 INT8911 Regulation of DHCR24 1 0.05 1.91 1.71
157 INT82609 Phosphorylation of SRC 17 0.80 6.45 1.7
158 INT109975 Positive_regulation of Kras 14 0.45 12.72 1.68
159 INT88412 Positive_regulation of CDK2 17 0.57 8.49 1.66
160 INT87282 Regulation of MAPK3 9 0.60 7.61 1.65
161 INT66709 Transcription of IGF1 13 0.71 5.65 1.64
162 INT173173 Regulation of Positive_regulation of MAPK14 6 0.38 2.59 1.64
163 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63
164 INT94169 Negative_regulation of Phosphorylation of RB1 16 0.41 8.87 1.57
165 INT241672 Positive_regulation of CCNA2 4 0.44 1.56 1.57
166 INT302790 Positive_regulation of Mapkapk5 1 0.25 2.6 1.55
167 INT182297 Positive_regulation of Phosphorylation of MAPK14 7 0.42 3.36 1.53
168 INT43327 Positive_regulation of ADRA2A 3 0.46 1.54 1.53
169 INT93624 Negative_regulation of Kras 3 0.41 1.15 1.52
170 INT85046 Positive_regulation of Positive_regulation of NTRK1 2 0.50 0.63 1.51
171 INT130019 Regulation of Phosphorylation of MAPK1 6 0.49 3.6 1.5
172 INT241668 Negative_regulation of Transcription of CCNA2 1 0.27 0.44 1.5
173 INT159091 Positive_regulation of Regulation of Sdcbp 1 0.40 0.16 1.5
174 INT122547 Positive_regulation of Positive_regulation of FGF2 3 0.44 3.1 1.49
175 INT97900 Negative_regulation of Gene_expression of FGF2 9 0.57 8.37 1.48
176 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
177 INT184206 Protein_catabolism of HRAS 22 0.66 7.86 1.46
178 INT24671 Binding of FGF2 14 0.35 8.73 1.43
179 INT173654 Localization of MAPK14 12 0.62 3.16 1.43
180 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
181 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
182 INT104121 Positive_regulation of MAP2K1 8 0.61 4.84 1.41
183 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
184 INT159303 Regulation of Negative_regulation of NGF 1 0.44 0.96 1.39
185 INT220073 Negative_regulation of Binding of NGF 1 0.23 1.1 1.39
186 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38
187 INT8068 Gene_expression of RASGRP1 29 0.54 15.1 1.37
188 INT145221 Binding of Tp53 10 0.37 8.59 1.37
189 INT71782 Gene_expression of MAP2K1 7 0.68 3.17 1.37
190 INT45233 Positive_regulation of Binding of Sdcbp 1 0.07 0 1.36
191 INT104027 Negative_regulation of Negative_regulation of MAPK1 6 0.56 2.87 1.35
192 INT154026 Negative_regulation of Regulation of Sdcbp 1 0.37 0 1.35
193 INT92383 Gene_expression of KRAS 38 0.65 32.94 1.32
194 INT114715 Binding of SRC 8 0.36 4.26 1.32
195 INT108601 Negative_regulation of Gene_expression of NTRK1 2 0.41 0.28 1.31
196 INT8063 Regulation of RASGRP1 15 0.36 9.15 1.3
197 INT54587 Positive_regulation of Hras1 12 0.27 5.54 1.3
198 INT85047 Positive_regulation of Negative_regulation of NTRK1 3 0.47 2.13 1.3
199 INT63905 Regulation of RB1 13 0.62 12.67 1.28
200 INT22815 Positive_regulation of RB1 20 0.49 14.58 1.26
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