GO:0007266

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Name Rho protein signal transduction
Categary Process
Go Slim No
Go Link GO:0007266
Unique Molecular Interactions 366
Total Molecular Interactions 538
Total Single Events 4601
Pain Genes Associated 44

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for Rho protein signal transduction. They are ordered first by their pain relevance and then by number of times they were reported for Rho protein signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
2 INT240057 Binding of RHOB and NME8 1 0.41 4.11 1.5
3 INT31772 Ednra Positive_regulation of Nppa 1 0.05 0.13 1.33
4 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
5 INT22501 Binding of Calca and Pth 1 0.21 0.07 1.28
6 INT172500 Ednra Positive_regulation of Coc 1 0.01 1 1.2
7 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
8 INT193288 CAP1 Positive_regulation of Pth 1 0.04 0.08 1.14
9 INT352295 Binding of P2RY2 and Agtr1a 1 0.01 0.08 1.02
10 INT110033 Adrb1 Positive_regulation of Gene_expression of Il12a 1 0.05 0 0.99
11 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
12 INT123023 Ednra Regulation of Adarb1 1 0.00 0 0.93
13 INT123024 Csf2 Regulation of Ednra 1 0.06 0 0.92
14 INT159962 Rock2 Regulation of Localization of Il6 1 0.09 2.7 0.88
15 INT199109 Binding of Akt1 and Arhgdia 1 0.02 2.73 0.87
16 INT186672 IL8 Positive_regulation of Transcription of PTH 1 0.01 1.83 0.85
17 INT128701 Ednra Regulation of EDNRB 1 0.17 0.58 0.84
18 INT128702 Ednra Regulation of EDNRA 1 0.00 0.58 0.84
19 INT69084 Binding of Adrb1 and Positive_regulation of Positive_regulation of Pdpk1 1 0.02 0.08 0.83
20 INT193275 Phax Regulation of Pth 1 0.01 0.16 0.81
21 INT128180 Gna12 Regulation of Regulation of RHOA 1 0.00 0 0.78
22 INT136795 Spp1 Positive_regulation of Chuk 1 0.11 1.54 0.77
23 INT148909 Binding of GNA13 and TP53INP2 1 0.06 0.31 0.73
24 INT33575 ADRB1 Positive_regulation of Localization of Ahsp 1 0.00 0.33 0.73
25 INT141063 Agt Regulation of Agtr1a 1 0.28 1.18 0.68
26 INT134286 PLD2 Regulation of Regulation of EDNRA 1 0.10 0 0.67
27 INT259776 Fbn2 Regulation of Negative_regulation of Agtr1a 1 0.00 1.42 0.66
28 INT62250 Fdft1 Regulation of Adrb1 1 0.00 0 0.65
29 INT136815 VEGFA Positive_regulation of Positive_regulation of RHOA 1 0.44 0.06 0.65
30 INT206206 Binding of Mcf2l and Obfc1 1 0.02 1.11 0.64
31 INT219921 EDNRA Negative_regulation of Trpv1 1 0.13 0.36 0.63
32 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
33 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
34 INT62249 Ghrh Regulation of Adrb1 1 0.00 0 0.62
35 INT259768 Positive_regulation of Agtr1a Regulation of Etf1 1 0.00 1.32 0.62
36 INT108020 Binding of Adrb1 and Clec4d 1 0.00 1.19 0.61
37 INT230734 Negative_regulation of Binding of EDNRA and Pah 1 0.02 3.26 0.61
38 INT230735 Binding of EDNRA and Pah 1 0.02 3.22 0.6
39 INT142993 Serpinc1 Positive_regulation of Phosphorylation of RHOA 1 0.05 0.05 0.59
40 INT193289 CAP1 Regulation of Pth 1 0.02 0 0.59
41 INT84603 Adrb1 Regulation of Gene_expression of Aqp2 1 0.00 0 0.56
42 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55
43 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53
44 INT79809 Binding of Agtr1a and Adra1a 1 0.02 0.23 0.53
45 INT147279 Binding of Calca and Pecam1 1 0.33 0.4 0.47
46 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
47 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
48 INT94093 Pnoc Positive_regulation of EDNRA 1 0.03 0.1 0.44
49 INT297316 Negative_regulation of Rock2 Positive_regulation of Cdh1 1 0.01 1.92 0.43
50 INT186673 IL8 Positive_regulation of Positive_regulation of PTH 1 0.01 0.92 0.42
51 INT147280 Binding of Pecam1 and Th 1 0.29 0.41 0.41
52 INT334763 Ednra Positive_regulation of Gabrg1 1 0.01 0 0.4
53 INT320810 Protein_catabolism of COL1A2 Positive_regulation of Localization of CYP27A1 1 0.04 1.05 0.4
54 INT182489 Gene_expression of AGTR2 Positive_regulation of Gene_expression of AGTR1 1 0.26 0.92 0.4
55 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
56 INT191493 Binding of AGTR1 and NLRP3 2 0.03 2.35 0.39
57 INT278932 Binding of Agtr1a and H3 1 0.00 0 0.39
58 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39
59 INT77683 Ednra Negative_regulation of LH 1 0.03 0.23 0.39
60 INT180442 Acot1 Positive_regulation of Rhoa 1 0.08 1.03 0.38
61 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38
62 INT80444 Binding of EDNRA and SPR 1 0.05 0.1 0.36
63 INT84602 Binding of Adrb1 and Avp 1 0.00 0 0.36
64 INT35981 Adrb1 Regulation of Localization of Prl 1 0.00 0 0.36
65 INT99292 Pth Positive_regulation of Jun 1 0.10 0.13 0.36
66 INT330122 Agt Positive_regulation of Gene_expression of Agtr1a 1 0.03 0.69 0.34
67 INT330121 Agtr1a Positive_regulation of Gene_expression of Bdkrb1 1 0.05 0.68 0.34
68 INT229363 Negative_regulation of Binding of Agt and Agtr1a 2 0.22 0.9 0.32
69 INT303030 Binding of Ednra and MCPH1 1 0.00 1.02 0.32
70 INT119603 H2-Ab1 Regulation of EDNRA 1 0.00 0.07 0.32
71 INT119602 EDNRA Regulation of H2-Ab1 1 0.00 0.07 0.32
72 INT303005 Binding of Ednra and Pah 1 0.06 1.02 0.32
73 INT285567 Binding of IL1B and Cdc42 1 0.03 0.77 0.31
74 INT69365 Binding of EDNRA and Pnoc 1 0.00 0 0.31
75 INT284137 EDNRB Regulation of EDNRA 1 0.07 0.09 0.3
76 INT117588 Binding of C5AR1 and EDNRA 1 0.40 0.38 0.3
77 INT224131 Binding of CAV1 and Agtr1a 1 0.00 0.08 0.3
78 INT254206 Il10 Negative_regulation of Chuk 1 0.05 0.59 0.29
79 INT254208 Il10 Negative_regulation of Regulation of Chuk 1 0.05 0.59 0.29
80 INT182499 Binding of AGTR1 and AGTR2 3 0.20 2.79 0.28
81 INT324801 Positive_regulation of Binding of Chuk and Irak1 1 0.03 0.86 0.28
82 INT178102 EDNRA Positive_regulation of Localization of TIMP1 1 0.06 0.97 0.28
83 INT324825 Binding of Chuk and Myd88 1 0.03 0.86 0.28
84 INT324810 Binding of Chuk and Irak1 1 0.02 0.85 0.28
85 INT178088 EDNRA Positive_regulation of Transcription of TIMP1 1 0.06 0.97 0.28
86 INT324806 Positive_regulation of Binding of Chuk and Myd88 1 0.04 0.86 0.28
87 INT170258 Pecam1 Positive_regulation of Icam1 1 0.02 0.79 0.27
88 INT239226 Binding of Edn1 and Ednra 2 0.06 1.59 0.26
89 INT143725 Chuk Negative_regulation of Phosphorylation of Nfkb1 1 0.17 0.71 0.26
90 INT124117 Apcs Negative_regulation of Ednra 1 0.09 0 0.26
91 INT219918 Positive_regulation of EDNRA Positive_regulation of Trpv1 1 0.13 0 0.26
92 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25
93 INT16163 Pth Regulation of Gene_expression of Plast4 1 0.00 0.65 0.25
94 INT36875 Binding of EDNRA and SYNCRIP 1 0.01 0 0.24
95 INT311989 Binding of Chuk and Mthfd1 1 0.05 0.56 0.24
96 INT193031 CHRM2 Positive_regulation of ROCK1 1 0.00 0.12 0.24
97 INT193029 CHRM2 Positive_regulation of RHOA 1 0.01 0.12 0.24
98 INT269561 TMPO Positive_regulation of RHOA 1 0.22 0 0.23
99 INT32735 ADRA2A Regulation of RTCA 1 0.07 0 0.22
100 INT63192 PTH Positive_regulation of ESR1 1 0.20 0.29 0.22
101 INT63201 PTH Positive_regulation of CD8A 1 0.45 0.29 0.22
102 INT284139 EDNRB Positive_regulation of Gene_expression of EDNRA 1 0.12 0.45 0.22
103 INT63200 PTH Positive_regulation of IL2 1 0.24 0.29 0.22
104 INT297257 Agtr1a Positive_regulation of Agtr2 1 0.27 0.59 0.22
105 INT63194 PTH Positive_regulation of PGR 1 0.25 0.29 0.22
106 INT306178 Rhoa Positive_regulation of Rock2 2 0.40 1.04 0.21
107 INT36876 EDNRA Regulation of Negative_regulation of PRB1 1 0.00 0 0.21
108 INT353285 Prdx2 Regulation of Gene_expression of Col1a2 1 0.02 0.73 0.21
109 INT229360 Agt Positive_regulation of Agtr1a 2 0.48 1.26 0.2
110 INT274080 Binding of ARHGAP4 and Map3k5 1 0.41 1.92 0.2
111 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2
112 INT178086 Binding of EDNRA and PTK2 1 0.07 0.82 0.2
113 INT343547 ROCK1 Positive_regulation of Gene_expression of PTHLH 1 0.15 0.2 0.2
114 INT180435 Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
115 INT230749 Crp Regulation of Agtr1a 1 0.07 1.33 0.19
116 INT224086 Binding of Agtr1a and Hspa8 1 0.00 0.1 0.19
117 INT180444 Positive_regulation of Acot1 Positive_regulation of Rhoa 1 0.08 0.43 0.19
118 INT180437 Positive_regulation of Acot1 Positive_regulation of Positive_regulation of Rhoa 1 0.08 0.43 0.19
119 INT58588 IFNG Positive_regulation of ARHGAP4 1 0.31 1.22 0.19
120 INT60778 Edn1 Positive_regulation of EDNRA 1 0.00 0 0.18
121 INT193080 ROCK1 Positive_regulation of Ppp1r14a 1 0.00 0.13 0.18
122 INT334769 Ednra Positive_regulation of Car2 1 0.02 0.49 0.18
123 INT224126 Binding of Hspa8 and Agtr1a 1 0.00 0.09 0.17
124 INT352290 Binding of Agtr1a and P2ry1 1 0.00 0 0.16
125 INT127206 Negative_regulation of Cftr Negative_regulation of Positive_regulation of Mcf2l 1 0.16 0.62 0.16
126 INT185793 SPP1 Positive_regulation of COL1A2 1 0.16 0.33 0.16
127 INT251349 Ifnar1 Positive_regulation of Rock1 1 0.01 1.27 0.16
128 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15
129 INT120553 Y-27632 Negative_regulation of Rock1 1 0.01 0.15 0.15
130 INT264868 Binding of COL1A2 and GOPC 1 0.02 0.3 0.15
131 INT120552 Y-27632 Negative_regulation of Rock2 1 0.02 0.15 0.15
132 INT222874 NDUFA6 Regulation of Chuk 1 0.01 1.57 0.15
133 INT293124 Agtr1a Regulation of Gene_expression of Aqp2 1 0.17 0.36 0.14
134 INT124412 Binding of PTH and Pth 1 0.02 0.65 0.14
135 INT293119 Agtr1a Regulation of Positive_regulation of Crh 1 0.12 0.37 0.14
136 INT309779 PTH Negative_regulation of Gene_expression of COL5A2 1 0.00 0.52 0.14
137 INT115205 Positive_regulation of Ednra Positive_regulation of Localization of Avp 1 0.36 0 0.14
138 INT334770 Ednra Positive_regulation of Pla2g4a 1 0.00 0.24 0.14
139 INT293123 Agtr1a Regulation of Negative_regulation of Agt 1 0.14 0.25 0.14
140 INT334765 Ednra Positive_regulation of Positive_regulation of Car2 1 0.02 0.24 0.14
141 INT180447 Binding of Rhoa and Car2 1 0.17 0.56 0.13
142 INT241454 Rgnef Positive_regulation of Positive_regulation of Rhoa 1 0.04 0.11 0.13
143 INT222876 Binding of NDUFA6 and Chuk 1 0.02 2.02 0.13
144 INT219920 EDNRA Positive_regulation of Trpv1 1 0.14 0 0.13
145 INT334759 Ednra Regulation of Gabrg1 1 0.01 0 0.13
146 INT269572 MAPKAP1 Positive_regulation of RHOA 1 0.06 0 0.13
147 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13
148 INT222875 Binding of NDUFA6 and Positive_regulation of Chuk 1 0.01 0.74 0.13
149 INT343542 ROCK1 Positive_regulation of Positive_regulation of PTHLH 1 0.21 0 0.12
150 INT110176 Nts Regulation of Negative_regulation of Agtr1a 1 0.24 0.09 0.12
151 INT269548 ARHGEF17 Positive_regulation of RHOA 1 0.01 0 0.12
152 INT326387 Binding of PROC and Rhoa 1 0.00 0.59 0.12
153 INT241446 Rgnef Positive_regulation of Rhoa 1 0.04 0.1 0.12
154 INT321965 Rock1 Positive_regulation of Nos3 1 0.28 1.99 0.12
155 INT229359 Agt Positive_regulation of Binding of Agtr1a 1 0.25 0.9 0.12
156 INT180445 Edn1 Positive_regulation of Rhoa 1 0.08 0.57 0.11
157 INT93535 PTH Negative_regulation of Gene_expression of Tnfsf11 1 0.19 0.22 0.11
158 INT323869 Binding of BMI1 and COL1A2 1 0.00 1.21 0.11
159 INT234060 Nes Positive_regulation of Pecam1 1 0.34 0.08 0.11
160 INT334761 Binding of Ednra and Gopc 1 0.03 0 0.11
161 INT83827 Negative_regulation of Binding of Adrb1 and Pnmt 1 0.02 0 0.1
162 INT293627 GHRL Positive_regulation of EDNRA 1 0.00 0.96 0.1
163 INT205055 MMP3 Negative_regulation of COL1A2 1 0.32 1.52 0.1
164 INT336990 Binding of AGTR1 and BDKRB2 1 0.03 0 0.1
165 INT83831 Binding of PNMT and Adrb1 1 0.02 0 0.1
166 INT118052 Binding of Pecam1 and Cd34 1 0.22 0.51 0.1
167 INT83828 Binding of Adrb1 and Pnmt 1 0.01 0 0.1
168 INT83832 Negative_regulation of Binding of PNMT and Adrb1 1 0.02 0 0.1
169 INT139476 Edn1 Positive_regulation of Ednra 1 0.00 1.07 0.1
170 INT207459 LGALS3 Regulation of Gene_expression of COL1A2 1 0.06 0.21 0.1
171 INT309780 Binding of PTH and PTH1R 3 0.12 0.3 0.09
172 INT180449 Rhoa Regulation of Positive_regulation of Car2 1 0.13 0 0.09
173 INT269592 MAPKAP1 Positive_regulation of Phosphorylation of CFL1 1 0.03 0 0.09
174 INT270731 Binding of AGTR1 and ACE 1 0.02 0.67 0.09
175 INT269593 MAPKAP1 Positive_regulation of Positive_regulation of RHOA 1 0.06 0 0.09
176 INT323868 LEP Regulation of Transcription of COL1A2 1 0.10 0.98 0.09
177 INT284141 Binding of EDNRA and PAH 1 0.05 0.1 0.09
178 INT180443 Rhoa Regulation of Negative_regulation of Mlc1 1 0.04 0 0.09
179 INT178089 Binding of EDNRA and Positive_regulation of PTK2 1 0.09 0.74 0.09
180 INT279707 Positive_regulation of AGTR1 Regulation of TYRP1 1 0.00 0 0.09
181 INT279706 Positive_regulation of AGTR1 Regulation of TRPC6 1 0.00 0 0.09
182 INT222873 NDUFA6 Negative_regulation of Phosphorylation of Chuk 1 0.01 0.24 0.08
183 INT214752 EDNRA Positive_regulation of PLCB1 1 0.02 0 0.08
184 INT88752 Map3k7 Negative_regulation of Ednra 1 0.05 0 0.08
185 INT249994 Binding of Agtr1a and Igkv4-55 1 0.01 0.38 0.08
186 INT350700 Binding of Bcl6 and thd 1 0.00 0.21 0.08
187 INT115204 Ednra Regulation of Localization of Avp 1 0.55 0 0.08
188 INT323876 LEP Regulation of COL1A2 1 0.10 0.86 0.08
189 INT163618 Chuk Regulation of Rela 1 0.16 0.23 0.08
190 INT350692 Binding of Bcl6 and Hand1 1 0.02 0.16 0.08
191 INT350720 Binding of Bcl6 and TBX21 1 0.07 0.22 0.08
192 INT291837 Binding of Pecam1 and Vegfa 1 0.09 1.1 0.07
193 INT231863 Binding of ARHGDIA and Akt1 1 0.02 0.23 0.07
194 INT192908 Edn1 Positive_regulation of Ednra 1 0.21 0.35 0.07
195 INT159854 Gene_expression of IL2 Regulation of Gene_expression of CDC42EP5 1 0.01 0.16 0.07
196 INT281900 Positive_regulation of Binding of AGT and AGTR1 1 0.12 0.16 0.07
197 INT337297 PTAFR Positive_regulation of EDNRA 1 0.04 1.2 0.06
198 INT178084 EDNRA Positive_regulation of Phosphorylation of GJA1 1 0.10 0.88 0.06
199 INT159851 Positive_regulation of RHOA Positive_regulation of Gene_expression of IL2 1 0.15 0.15 0.06
200 INT200641 Binding of ACE and Agtr1a 1 0.12 0.92 0.06

Single Events

The table below shows the top 100 pain related interactions that have been reported for Rho protein signal transduction. They are ordered first by their pain relevance and then by number of times they were reported in Rho protein signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54
2 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26
3 INT97 Negative_regulation of Adrb1 102 0.59 32.44 26.9
4 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
5 INT6728 Gene_expression of Ednra 43 0.65 13.41 17.38
6 INT85964 Gene_expression of Pecam1 109 0.78 69.73 15.21
7 INT170 Negative_regulation of Adrb1 52 0.55 13.46 14.78
8 INT95 Positive_regulation of Adrb1 34 0.62 11.95 14.41
9 INT79703 Gene_expression of Agtr1a 46 0.76 14.18 13.77
10 INT146197 Positive_regulation of Rhoa 60 0.68 34.12 12.02
11 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79
12 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7
13 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68
14 INT82684 Positive_regulation of Pecam1 27 0.49 25.67 11.47
15 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29
16 INT59 Regulation of Adrb1 25 0.42 8.32 9.78
17 INT82685 Gene_expression of Pecam1 36 0.76 27.95 9.01
18 INT30247 Regulation of Adrb1 18 0.44 4.45 8.93
19 INT22083 Regulation of Pth 55 0.62 22.32 8.9
20 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71
21 INT96 Binding of Adrb1 18 0.48 2.8 8.52
22 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29
23 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24
24 INT30382 Negative_regulation of Ednra 21 0.42 12.06 8.19
25 INT77804 Regulation of Ednra 9 0.39 2.71 7.94
26 INT54978 Binding of EDNRA 36 0.41 14.97 7.86
27 INT26115 Gene_expression of Adrb1 14 0.64 5.13 7.78
28 INT23992 Positive_regulation of Adrb1 25 0.56 4.01 7.62
29 INT102351 Regulation of Pecam1 7 0.61 22.45 7.58
30 INT67170 Gene_expression of Ednra 22 0.65 9.35 7.57
31 INT85968 Positive_regulation of Pecam1 19 0.69 29.04 7.5
32 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27
33 INT127203 Positive_regulation of Mcf2l 14 0.43 9.84 7.03
34 INT167049 Binding of Ednra 3 0.07 3.47 6.84
35 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
36 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33
37 INT142065 Phosphorylation of CFL1 8 0.78 0.87 6.3
38 INT123563 Negative_regulation of Rock1 7 0.55 16.56 5.78
39 INT113700 Positive_regulation of Chuk 30 0.41 21.17 5.69
40 INT120550 Negative_regulation of Rock1 27 0.42 18.38 5.66
41 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49
42 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36
43 INT102891 Positive_regulation of AGTR1 31 0.67 30.57 5.29
44 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15
45 INT84561 Binding of COL1A2 18 0.47 11.76 5.09
46 INT62570 Binding of Pth 48 0.48 26.45 4.85
47 INT92858 Negative_regulation of Ednra 6 0.57 1.25 4.81
48 INT20944 Gene_expression of Mcf2l 13 0.58 5.96 4.76
49 INT128178 Positive_regulation of RHOA 59 0.68 9.3 4.7
50 INT246315 Localization of Ednra 22 0.15 2.73 4.64
51 INT21953 Binding of Ednra 12 0.33 4.72 4.56
52 INT4097 Localization of Pth 66 0.81 47.17 4.36
53 INT53040 Binding of Agtr1a 22 0.47 7.36 4.15
54 INT127202 Negative_regulation of Mcf2l 8 0.50 6.7 4.15
55 INT465 Binding of Adrb1 14 0.35 3.04 4.07
56 INT156137 Gene_expression of Col1a2 28 0.73 13.3 3.99
57 INT142066 Positive_regulation of Phosphorylation of CFL1 5 0.48 0.24 3.73
58 INT123564 Negative_regulation of Rock2 13 0.59 9.61 3.58
59 INT49238 Protein_catabolism of COL1A2 30 0.97 15.64 3.45
60 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39
61 INT115203 Negative_regulation of Positive_regulation of Ednra 5 0.33 1.27 3.32
62 INT127200 Localization of Mcf2l 7 0.64 4.8 3.25
63 INT146194 Negative_regulation of Rhoa 21 0.42 11.05 3.22
64 INT111195 Negative_regulation of Gene_expression of Agtr1a 7 0.58 3.2 3.16
65 INT28094 Binding of PTH 29 0.37 13.57 3.09
66 INT49971 Regulation of Ednra 10 0.35 2.4 3.06
67 INT128179 Gene_expression of RHOA 7 0.64 2.48 3.01
68 INT174958 Negative_regulation of Chuk 21 0.25 8.73 2.96
69 INT146191 Gene_expression of Rhoa 32 0.67 17.63 2.92
70 INT93058 Positive_regulation of Gene_expression of Ednra 8 0.28 4.11 2.88
71 INT22500 Negative_regulation of Pth 6 0.43 3.41 2.83
72 INT76836 Positive_regulation of Ednra 6 0.55 2.65 2.72
73 INT222845 Gene_expression of Chuk 27 0.52 25.15 2.67
74 INT120551 Negative_regulation of Rock2 8 0.52 2.73 2.53
75 INT63418 Regulation of Agtr1a 8 0.44 3.67 2.43
76 INT128174 Positive_regulation of Gene_expression of RHOA 7 0.36 1.5 2.36
77 INT84881 Positive_regulation of Gene_expression of Pecam1 5 0.46 5.79 2.35
78 INT25666 Negative_regulation of ADRB1 11 0.44 3.12 2.33
79 INT22715 Positive_regulation of Gene_expression of Pth 29 0.64 22.53 2.31
80 INT146196 Localization of Rhoa 6 0.78 4.68 2.3
81 INT4495 Gene_expression of Adrb1 7 0.66 2.43 2.29
82 INT61684 Localization of COL1A2 20 0.73 9.31 2.26
83 INT2544 Localization of PTH 39 0.81 30.55 2.22
84 INT102979 Negative_regulation of Gene_expression of Pecam1 5 0.40 4.95 2.21
85 INT89519 Negative_regulation of COL1A2 10 0.36 6.26 2.17
86 INT146192 Positive_regulation of Positive_regulation of Rhoa 8 0.60 8.15 2.17
87 INT94 Positive_regulation of Negative_regulation of Adrb1 4 0.46 0.97 2.16
88 INT142064 Negative_regulation of Phosphorylation of CFL1 3 0.56 0.42 2.06
89 INT156677 Regulation of Gene_expression of Ednra 4 0.15 0.25 2.05
90 INT152155 Positive_regulation of Col1a2 7 0.56 10.18 1.89
91 INT23426 Regulation of ADRA2A 8 0.48 1.81 1.88
92 INT146193 Negative_regulation of Positive_regulation of Rhoa 3 0.42 3 1.84
93 INT240058 Gene_expression of RHOB 2 0.55 4.29 1.84
94 INT85348 Localization of RHOA 12 0.59 4.81 1.83
95 INT23884 Negative_regulation of Negative_regulation of Adrb1 7 0.38 2.3 1.83
96 INT182505 Positive_regulation of Gene_expression of AGTR1 12 0.65 13.18 1.77
97 INT32176 Negative_regulation of Negative_regulation of Adrb1 2 0.40 0.4 1.77
98 INT128168 Positive_regulation of Gna12 1 0.01 0 1.76
99 INT84375 Regulation of COL1A2 6 0.44 8.75 1.72
100 INT110026 Localization of Adrb1 4 0.72 1.56 1.71
101 INT1731 Localization of Adrb1 5 0.43 0.31 1.67
102 INT3343 Regulation of PTH 24 0.62 11.18 1.62
103 INT240059 Binding of RHOB 7 0.48 3.96 1.59
104 INT67708 Binding of Pecam1 9 0.32 3.12 1.58
105 INT139317 Negative_regulation of Col1a2 8 0.41 7.17 1.54
106 INT128170 Gene_expression of Gna12 1 0.01 0 1.54
107 INT72021 Localization of Ednra 7 0.58 3.13 1.53
108 INT43327 Positive_regulation of ADRA2A 3 0.46 1.54 1.53
109 INT146190 Negative_regulation of Localization of Rhoa 4 0.42 1.64 1.5
110 INT182514 Binding of AGTR1 18 0.47 13.35 1.48
111 INT23938 Positive_regulation of Gene_expression of EDNRA 8 0.45 9.82 1.47
112 INT129488 Regulation of Gene_expression of EDNRA 5 0.51 3.39 1.44
113 INT62669 Positive_regulation of COL1A2 13 0.49 6.89 1.4
114 INT182511 Regulation of AGTR1 7 0.44 8.25 1.4
115 INT85967 Positive_regulation of Gene_expression of Pecam1 6 0.50 6.22 1.39
116 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37
117 INT83553 Positive_regulation of Positive_regulation of Agtr1a 3 0.59 4.12 1.37
118 INT143716 Phosphorylation of Chuk 16 0.41 5.25 1.35
119 INT32118 Regulation of Mcf2l 6 0.39 3.05 1.34
120 INT38312 Positive_regulation of Gene_expression of Adrb1 2 0.07 0.22 1.33
121 INT217438 Binding of Chuk 24 0.25 7.29 1.29
122 INT39500 Positive_regulation of Positive_regulation of Pth 14 0.48 9.75 1.28
123 INT142992 Phosphorylation of RHOA 3 0.80 0.87 1.28
124 INT128176 Regulation of RHOA 13 0.44 4.35 1.26
125 INT22498 Binding of Pth 2 0.48 2.81 1.24
126 INT269185 Regulation of Gene_expression of Pecam1 2 0.45 3.75 1.24
127 INT168720 Regulation of Negative_regulation of Rock1 1 0.43 1.31 1.23
128 INT151513 Negative_regulation of Gene_expression of Pecam1 8 0.37 4.73 1.22
129 INT349026 Positive_regulation of Regulation of Pecam1 1 0.46 3.9 1.17
130 INT180095 Gene_expression of Rock1 22 0.55 4.9 1.14
131 INT72749 Regulation of Pth 4 0.62 1.39 1.14
132 INT126534 Negative_regulation of ROCK1 18 0.49 14.32 1.13
133 INT148072 Gene_expression of Agtr1a 5 0.75 9.41 1.13
134 INT82214 Transcription of PTH 6 0.54 3.33 1.11
135 INT146198 Positive_regulation of Rock1 16 0.49 5.86 1.1
136 INT101104 Positive_regulation of Gene_expression of COL1A2 12 0.69 5.87 1.09
137 INT146553 Positive_regulation of Rock2 4 0.44 2.56 1.09
138 INT263403 Positive_regulation of Rock1 3 0.38 4.68 1.09
139 INT111858 Regulation of Rock1 1 0.41 0.75 1.09
140 INT140159 Regulation of Gene_expression of Adrb1 1 0.00 0.17 1.07
141 INT136044 Gene_expression of Rock2 7 0.78 0.19 1.06
142 INT136817 Negative_regulation of Positive_regulation of RHOA 8 0.57 0 1.04
143 INT133102 Negative_regulation of Gene_expression of COL1A2 8 0.08 2.56 1.02
144 INT71031 Gene_expression of ADRB1 5 0.55 2.96 1.01
145 INT12976 Negative_regulation of ADRA2A 4 0.50 0.16 1.01
146 INT102978 Negative_regulation of Pecam1 2 0.48 2.24 1.01
147 INT180423 Positive_regulation of Gene_expression of Rhoa 7 0.40 6.22 0.98
148 INT33442 Regulation of ADRB1 2 0.04 0.38 0.98
149 INT127199 Negative_regulation of Positive_regulation of Mcf2l 1 0.14 2.77 0.98
150 INT23030 Positive_regulation of Pth 13 0.61 9.24 0.97
151 INT12555 Binding of ADRB1 7 0.39 3.78 0.97
152 INT182512 Positive_regulation of Positive_regulation of AGTR1 5 0.47 4.88 0.97
153 INT42420 Negative_regulation of Binding of Adrb1 2 0.58 0.8 0.97
154 INT72024 Localization of EDNRA 11 0.57 8.22 0.96
155 INT76835 Negative_regulation of Gene_expression of Ednra 2 0.10 0.89 0.96
156 INT352919 Positive_regulation of Gene_expression of RHOB 1 0.35 2.21 0.96
157 INT4096 Regulation of Localization of Pth 7 0.58 3.97 0.95
158 INT155867 Transcription of COL1A2 8 0.69 2.9 0.94
159 INT31828 Transcription of Adrb1 2 0.27 0.18 0.94
160 INT131824 Negative_regulation of RHOA 10 0.57 2.9 0.92
161 INT53710 Regulation of Negative_regulation of Arhgdia 1 0.18 0 0.92
162 INT204547 Positive_regulation of Gene_expression of Col1a2 2 0.04 2.08 0.91
163 INT53711 Negative_regulation of Arhgdia 1 0.28 0 0.91
164 INT161682 Positive_regulation of Cdc42 8 0.53 4.55 0.9
165 INT178133 Negative_regulation of Positive_regulation of EDNRA 2 0.35 2.18 0.88
166 INT70724 Positive_regulation of Negative_regulation of ADRB1 1 0.38 0.2 0.86
167 INT128171 Positive_regulation of Gene_expression of Gna12 1 0.01 0 0.85
168 INT146195 Positive_regulation of Localization of Rhoa 4 0.45 2.67 0.84
169 INT229710 Localization of Agtr1a 3 0.60 0.57 0.84
170 INT1732 Positive_regulation of Localization of Adrb1 2 0.22 0.06 0.8
171 INT146199 Negative_regulation of Negative_regulation of Rock1 1 0.22 0.7 0.8
172 INT231380 Negative_regulation of Phosphorylation of Rhoa 1 0.13 1.28 0.79
173 INT32751 Regulation of Positive_regulation of Adrb1 2 0.36 0.07 0.77
174 INT186579 Positive_regulation of Gene_expression of Ednra 5 0.07 0.89 0.76
175 INT18836 Localization of ADRA2A 2 0.38 0.33 0.76
176 INT173338 Positive_regulation of Localization of RHOA 2 0.14 1.52 0.76
177 INT102894 Localization of AGTR1 5 0.73 1.75 0.74
178 INT85347 Negative_regulation of Localization of RHOA 1 0.31 0 0.74
179 INT320992 Positive_regulation of Positive_regulation of Pecam1 5 0.50 4.23 0.73
180 INT231369 Phosphorylation of Rhoa 1 0.25 1.22 0.73
181 INT91384 Positive_regulation of Localization of COL1A2 3 0.49 1.42 0.71
182 INT156138 Negative_regulation of Gene_expression of Col1a2 2 0.55 2.07 0.7
183 INT128169 Regulation of Gene_expression of Gna12 1 0.01 0 0.7
184 INT313697 Phosphorylation of Ednra 1 0.18 0 0.7
185 INT142063 Negative_regulation of CFL1 1 0.56 0 0.69
186 INT43481 Positive_regulation of ADRB1 3 0.19 1.36 0.68
187 INT148911 Positive_regulation of Positive_regulation of GNA13 1 0.08 0.28 0.68
188 INT148912 Positive_regulation of GNA13 1 0.12 0.28 0.68
189 INT116946 Positive_regulation of CDC42EP5 3 0.05 1.89 0.66
190 INT111196 Negative_regulation of Negative_regulation of Agtr1a 2 0.42 0.49 0.65
191 INT62067 Negative_regulation of Gene_expression of Pth 13 0.41 8.24 0.61
192 INT211489 Gene_expression of ARHGAP4 6 0.65 2.88 0.61
193 INT24095 Protein_catabolism of Adrb1 2 0.10 0.59 0.61
194 INT83826 Negative_regulation of Binding of Adrb1 3 0.25 0.67 0.6
195 INT180107 Regulation of Cdc42 3 0.16 0.18 0.6
196 INT167608 Regulation of Rock2 2 0.33 2.47 0.59
197 INT236711 Gene_expression of Bcl6 15 0.30 12.98 0.58
198 INT143713 Positive_regulation of Phosphorylation of Chuk 4 0.25 1.38 0.58
199 INT50016 Positive_regulation of ARHGAP4 3 0.49 1.8 0.58
200 INT155770 Protein_catabolism of Mcf2l 1 0.56 0.05 0.58
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