GO:0007267

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Name cell-cell signaling
Categary Process
Go Slim Yes
Go Link GO:0007267
Unique Molecular Interactions 3934
Total Molecular Interactions 5955
Total Single Events 50910
Pain Genes Associated 190

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cell-cell signaling. They are ordered first by their pain relevance and then by number of times they were reported for cell-cell signaling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT6078 Pomc Positive_regulation of Localization of Penk 13 0.51 0 15.49
3 INT166591 Binding of CALCA and DCLK3 4 0.30 0.69 12.18
4 INT10268 Binding of PDYN and POMC 11 0.39 0.08 10.36
5 INT6079 Pomc Positive_regulation of Penk 9 0.43 0 9.46
6 INT2714 Pomc Positive_regulation of Localization of Prl 17 0.79 0.5 8.18
7 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73
8 INT91538 Pomc Positive_regulation of P9Ehs1 6 0.11 1.47 6.23
9 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09
10 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87
11 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
12 INT92466 Pomc Positive_regulation of Binding of Crygs 8 0.06 0 5.56
13 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05
14 INT1310 Pomc Regulation of Localization of Prl 9 0.40 0.61 4.96
15 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68
16 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
17 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
18 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
19 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
20 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
21 INT1313 Pomc Positive_regulation of Prl 7 0.35 0 4.19
22 INT29240 Binding of POMC and YY1 5 0.40 0.17 4.06
23 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
24 INT20456 Binding of Pomc and Penk 9 0.41 0.26 3.93
25 INT69032 IL18 Positive_regulation of IFNA1 12 0.23 7.87 3.83
26 INT181455 Binding of Ccr5 and Ccl5 11 0.39 12.13 3.66
27 INT87491 CALCA Positive_regulation of Gene_expression of IL8 1 0.72 0.92 3.52
28 INT108473 Binding of ADCYAP1 and PNOC 1 0.32 0.64 3.41
29 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35
30 INT7436 CFP Positive_regulation of Binding of POMC 1 0.02 0.18 3.35
31 INT189488 Binding of Ccr1 and Ccl5 8 0.40 9.26 3.27
32 INT108471 Binding of CALCA and PNOC 1 0.29 0.64 3.25
33 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22
34 INT13729 GHRH Positive_regulation of Localization of GH1 13 0.62 0.59 3.2
35 INT17456 Binding of CSF2 and POMC 3 0.32 4.06 3.15
36 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
37 INT6076 Negative_regulation of Pomc Positive_regulation of Penk 3 0.31 0 3.14
38 INT81708 POMC Regulation of Gene_expression of ITGAM 1 0.53 0.72 3.1
39 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3
40 INT202965 Binding of STC2 and BAG3 1 0.02 7.86 2.96
41 INT166592 Binding of CALCA and RAMP1 2 0.35 0.33 2.91
42 INT73821 CALCA Positive_regulation of Localization of IL8 1 0.25 2.37 2.91
43 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9
44 INT318996 Binding of CCR3 and CCL5 1 0.07 3.39 2.9
45 INT319003 Binding of CCR1 and CCL5 1 0.08 3.38 2.89
46 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
47 INT194409 Binding of CALCA and IGKV1D-8 1 0.15 0 2.84
48 INT32656 Pomc Positive_regulation of Rbm39 1 0.08 0.42 2.84
49 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
50 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78
51 INT69030 IL18 Positive_regulation of IL12A 3 0.31 5.57 2.72
52 INT30345 Pomc Regulation of Localization of Penk 3 0.31 0 2.61
53 INT189490 Binding of Ccr3 and Ccl5 1 0.33 8.54 2.6
54 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58
55 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46
56 INT21520 Crh Regulation of Pomc 3 0.22 0.4 2.45
57 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
58 INT318998 IFNA1 Positive_regulation of Localization of CXCL10 1 0.15 2.09 2.39
59 INT214144 Cck Positive_regulation of Pomc 1 0.15 0.94 2.39
60 INT152900 TRPV1 Regulation of Gene_expression of CALCA 1 0.69 0.73 2.29
61 INT152901 TRPV1 Regulation of Localization of CALCA 1 0.44 0.73 2.29
62 INT51317 Binding of POMC and OR5D2P 1 0.00 0.6 2.23
63 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21
64 INT34310 CRH Positive_regulation of POMC 3 0.42 0.62 2.21
65 INT312690 CP Positive_regulation of CCL20 1 0.11 8.23 2.2
66 INT32586 H2-Ab1 Regulation of Pomc 1 0.03 0.14 2.19
67 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
68 INT1315 Pomc Positive_regulation of Localization of Gnrhr 3 0.38 0.16 2.16
69 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
70 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
71 INT28387 Pomc Positive_regulation of Localization of LH 2 0.40 0.28 2.07
72 INT182200 Binding of CXCR5 and CXCL13 1 0.37 2.89 2.07
73 INT202963 Binding of STC2 and CPP 1 0.02 5.16 2.04
74 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01
75 INT138962 Dbi Positive_regulation of Pomc 1 0.00 1.53 2
76 INT32585 H2-Ab1 Negative_regulation of Pomc 1 0.03 0.13 2
77 INT60626 Crh Positive_regulation of Localization of Pomc 7 0.54 2.3 1.99
78 INT26948 Pomc Positive_regulation of Localization of Gh1 2 0.22 0.15 1.99
79 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
80 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
81 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
82 INT31438 Penk Positive_regulation of Localization of Pomc 1 0.18 0 1.9
83 INT24942 Calca Regulation of TAC1 1 0.13 0.7 1.89
84 INT271408 NGF Positive_regulation of Gene_expression of CALCA 1 0.09 4.89 1.88
85 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
86 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
87 INT201940 Binding of IL8 and CXCL10 2 0.28 2.46 1.86
88 INT13940 DNM2 Regulation of Localization of CGA 1 0.11 0 1.86
89 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
90 INT16891 GHRH Regulation of GH1 5 0.37 1.94 1.82
91 INT19496 Pomc Regulation of Localization of Ins1 1 0.55 0.33 1.82
92 INT128654 ITIH4 Regulation of Gene_expression of CCL16 1 0.02 2.69 1.79
93 INT179444 Hmmr Negative_regulation of Gpr156 1 0.03 0 1.79
94 INT57249 GNRH1 Regulation of Regulation of CGA 1 0.20 0 1.74
95 INT26676 Pomc Regulation of Localization of Trh 3 0.14 0 1.73
96 INT24817 Binding of POMC and VTN 8 0.42 0.39 1.71
97 INT148090 Binding of CALCA and NCOR2 1 0.00 0.65 1.71
98 INT119413 SEMA6A Positive_regulation of TNFRSF11A 1 0.10 2.48 1.7
99 INT30134 Binding of TPP1 and S100A9 1 0.13 0.74 1.69
100 INT56134 CALCA Positive_regulation of POMC 2 0.71 0.72 1.68
101 INT45306 Pomc Positive_regulation of ENG 2 0.07 1.11 1.68
102 INT102447 Binding of CALCA and CALCRL 2 0.26 0.33 1.67
103 INT151889 Binding of Adarb1 and DLL1 1 0.00 0 1.66
104 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
105 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
106 INT24157 Binding of CALCA and SFTPA1 2 0.07 0.96 1.64
107 INT169441 TAC1 Positive_regulation of Tac1 1 0.01 1.7 1.64
108 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
109 INT32412 Penk Regulation of Pomc 3 0.21 0.36 1.62
110 INT86637 POMC Regulation of Gene_expression of KRT16 2 0.47 1.22 1.61
111 INT160578 Binding of CALCA and TAC1 1 0.07 0.91 1.61
112 INT94270 Pomc Regulation of Transcription of Crh 1 0.17 0.67 1.6
113 INT33757 Hmmr Positive_regulation of Npr1 1 0.01 0 1.59
114 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
115 INT66408 Pomc Positive_regulation of Regulation of HRH1 1 0.01 0 1.58
116 INT342993 PHEX Regulation of Protein_catabolism of SFTPA1 1 0.00 2.84 1.58
117 INT33759 Hmmr Positive_regulation of Akr1d1 1 0.00 0 1.58
118 INT41652 Binding of Pomc and Oprl1 3 0.16 0 1.57
119 INT94271 Pomc Regulation of Avp 1 0.20 0.67 1.57
120 INT81710 POMC Regulation of Gene_expression of FCGR3B 1 0.50 0.34 1.57
121 INT81709 POMC Regulation of Gene_expression of ITGB2 1 0.40 0.34 1.57
122 INT81719 POMC Regulation of Gene_expression of ITGAL 1 0.35 0.34 1.57
123 INT81712 POMC Regulation of FCGR3B 1 0.16 0.34 1.56
124 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
125 INT81715 POMC Regulation of ITGB2 1 0.40 0.34 1.55
126 INT81721 POMC Regulation of ITGAM 1 0.39 0.34 1.55
127 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
128 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54
129 INT81714 POMC Regulation of ITGAL 1 0.15 0.34 1.54
130 INT73016 PDYN Regulation of TAC1 1 0.29 0.34 1.54
131 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
132 INT32152 POMC Positive_regulation of Gene_expression of IFNA1 2 0.67 0 1.53
133 INT41101 Mdk Negative_regulation of SST 1 0.02 0 1.53
134 INT145072 ASIP Negative_regulation of MC1R 1 0.29 0 1.52
135 INT23548 Negative_regulation of CNDP2 Negative_regulation of Localization of POMC 1 0.03 0 1.52
136 INT140017 Avp Positive_regulation of Gene_expression of Pomc 1 0.38 0.85 1.52
137 INT69709 NPL Positive_regulation of Localization of POMC 2 0.36 1.22 1.51
138 INT32657 Positive_regulation of Pomc Positive_regulation of Rbm39 1 0.08 0.22 1.51
139 INT76656 POMC Positive_regulation of Gene_expression of Il6 1 0.03 0 1.51
140 INT140008 Avp Positive_regulation of Pomc 1 0.38 0.84 1.51
141 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5
142 INT222185 Binding of Ccr1 and Ccl3 4 0.23 2.7 1.47
143 INT96784 Binding of CALCA and Calca 3 0.23 0.27 1.47
144 INT40209 TNS3 Regulation of POMC 1 0.16 0.27 1.47
145 INT12691 SST Negative_regulation of Localization of POMC 3 0.24 1.24 1.45
146 INT1314 Pomc Regulation of Localization of Gnrhr 2 0.16 0.14 1.45
147 INT21425 Binding of Pomc and Gtpbp4 1 0.01 0.1 1.45
148 INT202958 Binding of STC2 and MCRS1 1 0.01 3.48 1.44
149 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
150 INT224404 Binding of GYPC and PYY 1 0.04 1.48 1.42
151 INT154111 POMC Positive_regulation of Localization of PENK 1 0.34 0.05 1.41
152 INT28992 Tmpo Positive_regulation of Pomc 1 0.36 3.18 1.41
153 INT154110 PENK Positive_regulation of Localization of POMC 1 0.34 0.05 1.41
154 INT154113 POMC Positive_regulation of YY1 1 0.70 0.06 1.41
155 INT71543 IFNA1 Negative_regulation of Positive_regulation of TAC1 1 0.20 0.19 1.4
156 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
157 INT222213 TFAM Positive_regulation of Gene_expression of Ccr1 1 0.02 3.96 1.4
158 INT27123 Binding of Pomc and Cck 2 0.31 0 1.38
159 INT51160 Binding of TAC1 and Tacr1 2 0.28 0.55 1.38
160 INT26812 SST Regulation of Localization of OXT 1 0.40 0.57 1.37
161 INT66569 Pomc Positive_regulation of Atxn2l 1 0.03 0 1.36
162 INT176368 IL18 Positive_regulation of Gene_expression of IFNA1 1 0.16 2.53 1.35
163 INT33988 TRH Regulation of Localization of IGKV1D-39 1 0.12 0.47 1.35
164 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
165 INT19633 GNRH1 Regulation of Localization of CGA 4 0.44 0.82 1.33
166 INT143999 IK Regulation of Gene_expression of Penk 1 0.04 0 1.33
167 INT38453 Binding of Pomc and Penk 1 0.17 0 1.33
168 INT2641 Binding of Pomc and Lct 2 0.31 0.57 1.32
169 INT59446 Rbm39 Positive_regulation of Negative_regulation of Pomc 1 0.03 0.19 1.32
170 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
171 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
172 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
173 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
174 INT96707 Ntf3 Positive_regulation of Localization of SST 1 0.01 0 1.3
175 INT96708 Bdnf Positive_regulation of Localization of SST 1 0.01 0 1.3
176 INT201942 DPP4 Negative_regulation of CXCL10 1 0.33 0.9 1.3
177 INT49231 TAC1 Negative_regulation of Penk 1 0.00 0 1.3
178 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
179 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
180 INT194408 Regulation of Binding of CALCA and DCLK3 1 0.15 0 1.29
181 INT89873 Pdyn Positive_regulation of Gene_expression of Gata4 1 0.23 0 1.29
182 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28
183 INT31008 Crh Positive_regulation of Pomc 3 0.49 2.31 1.28
184 INT86636 POMC Positive_regulation of Gene_expression of KRT16 2 0.39 0.83 1.28
185 INT89876 Pdyn Positive_regulation of Gata4 1 0.23 0 1.28
186 INT48117 GH1 Positive_regulation of CGA 1 0.10 0 1.28
187 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27
188 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
189 INT34052 POMC Regulation of Gene_expression of IFNG 1 0.11 0 1.27
190 INT70226 Binding of TAC1 and B3GAT1 4 0.24 4.5 1.26
191 INT70037 TNF Regulation of IL10 2 0.09 2.11 1.26
192 INT5518 Pomc Negative_regulation of Crh 2 0.36 0.42 1.26
193 INT42580 CAT Negative_regulation of POMC 1 0.20 0.42 1.26
194 INT46853 POMC Regulation of GAST 1 0.11 0.07 1.26
195 INT45269 POMC Negative_regulation of Penk 1 0.01 0 1.24
196 INT34471 Negative_regulation of Pomc Regulation of Slc3a1 1 0.05 0.12 1.24
197 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
198 INT172141 IL10 Negative_regulation of Gene_expression of HLA-DRA 2 0.14 0.89 1.23
199 INT123453 Binding of POMC and Penk 1 0.01 0.31 1.23
200 INT50385 Bdnf Positive_regulation of Pomc 1 0.22 0.47 1.23

Single Events

The table below shows the top 100 pain related interactions that have been reported for cell-cell signaling. They are ordered first by their pain relevance and then by number of times they were reported in cell-cell signaling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT443 Localization of POMC 1020 0.81 284.52 443.17
2 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16
3 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83
4 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98
5 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
6 INT738 Regulation of POMC 459 0.62 111.19 243.74
7 INT626 Localization of CALCA 289 0.81 125.39 221.15
8 INT1308 Localization of Pomc 457 0.81 66.83 217.5
9 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24
10 INT1652 Regulation of Pomc 387 0.62 61.01 186.51
11 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77
12 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63
13 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37
14 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69
15 INT812 Localization of INS 1026 0.81 515.6 145.31
16 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47
17 INT695 Binding of POMC 304 0.48 56.66 126.85
18 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64
19 INT7395 Localization of GNRH1 399 0.81 62.88 117.68
20 INT1438 Localization of Pomc 360 0.81 101.26 116.47
21 INT1793 Localization of CGA 379 0.81 67.38 114.69
22 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84
23 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
24 INT397 Localization of SST 232 0.81 58.05 101.19
25 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
26 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61
27 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84
28 INT214 Localization of AVP 370 0.81 208.51 91.09
29 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
30 INT6849 Localization of IL1B 229 0.81 112.56 69.63
31 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26
32 INT462 Regulation of Pomc 157 0.62 41.67 67.27
33 INT8347 Gene_expression of SST 181 0.78 104.59 65.45
34 INT6761 Binding of CALCA 100 0.48 26.71 62.05
35 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97
36 INT1794 Regulation of Localization of CGA 136 0.57 13.39 59.07
37 INT1307 Positive_regulation of Localization of Pomc 120 0.70 24.58 58.48
38 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74
39 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34
40 INT1463 Binding of Pomc 129 0.48 15.89 56.27
41 INT4241 Regulation of CALCA 87 0.62 28.19 55.29
42 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09
43 INT251 Regulation of INS 398 0.62 232.47 55.04
44 INT5506 Positive_regulation of Gene_expression of Pomc 132 0.70 26.78 54.3
45 INT249 Localization of GHRH 215 0.80 78.02 51.87
46 INT52264 Gene_expression of IK 180 0.77 90.87 51.87
47 INT5118 Regulation of SST 97 0.62 34.35 51.74
48 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34
49 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
50 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
51 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02
52 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41
53 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
54 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
55 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33
56 INT4776 Localization of TAC1 82 0.78 16.89 45.21
57 INT109910 Gene_expression of CCL16 104 0.74 76.1 43.97
58 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5
59 INT1295 Binding of Pomc 85 0.48 12.92 42.8
60 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8
61 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08
62 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
63 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52
64 INT685 Regulation of AVP 124 0.62 34.9 39.91
65 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
66 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84
67 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
68 INT2782 Regulation of Gene_expression of Pomc 75 0.62 15.04 38.97
69 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67
70 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
71 INT8837 Positive_regulation of TAC1 59 0.67 21.94 35.97
72 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23
73 INT6484 Binding of IL1B 122 0.47 75.84 35.07
74 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
75 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67
76 INT692 Negative_regulation of SST 72 0.59 28.68 34.52
77 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
78 INT10763 Localization of IL2 157 0.80 81.11 33.21
79 INT7133 Negative_regulation of MME 85 0.59 29.22 33.1
80 INT4727 Regulation of TAC1 60 0.47 6.74 32.83
81 INT5868 Positive_regulation of GNRH1 122 0.69 20.96 32.8
82 INT691 Binding of SST 67 0.48 24.66 32.67
83 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26
84 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7
85 INT94388 Gene_expression of GDF15 124 0.77 79.48 31.42
86 INT22239 Negative_regulation of TAC1 52 0.57 12.96 31.41
87 INT7396 Regulation of Localization of GNRH1 81 0.62 6.57 31.31
88 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11
89 INT6277 Positive_regulation of Gene_expression of Pomc 76 0.70 21.45 31.09
90 INT15347 Positive_regulation of Localization of Pomc 81 0.70 28.1 31.01
91 INT5505 Regulation of Localization of Pomc 54 0.61 6.96 30.77
92 INT9993 Positive_regulation of Gene_expression of IL2 131 0.69 46.27 30.04
93 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96
94 INT7397 Negative_regulation of Localization of GNRH1 86 0.59 15.45 29.78
95 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48
96 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76
97 INT1196 Positive_regulation of Positive_regulation of POMC 51 0.70 15.99 28.58
98 INT7035 Regulation of CGA 87 0.45 29.04 28.45
99 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
100 INT5135 Negative_regulation of GNRH1 106 0.58 36.63 27.71
101 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69
102 INT7565 Transcription of Pomc 69 0.72 14.46 27.41
103 INT5206 Gene_expression of AR 316 0.78 113.83 27.29
104 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95
105 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66
106 INT8779 Binding of TAC1 50 0.47 11.19 25.57
107 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29
108 INT130186 Gene_expression of Ccl5 101 0.74 79.96 25.01
109 INT4877 Gene_expression of MME 184 0.78 122.82 24.78
110 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77
111 INT64185 Gene_expression of TNFRSF11A 131 0.76 75.15 24.73
112 INT141612 Gene_expression of Ccr1 92 0.77 72.09 24.14
113 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
114 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94
115 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91
116 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
117 INT7113 Negative_regulation of Localization of CGA 71 0.51 17.7 23.42
118 INT2290 Protein_catabolism of POMC 41 0.99 4.86 23.36
119 INT9526 Negative_regulation of Localization of Pomc 41 0.58 6.93 23.3
120 INT250 Regulation of GHRH 65 0.61 17.46 23.19
121 INT5511 Negative_regulation of Gene_expression of Pomc 47 0.59 12.08 23.02
122 INT94335 Positive_regulation of CXCL10 71 0.58 50.69 23
123 INT74423 Localization of IL10 91 0.80 61.6 22.95
124 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78
125 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73
126 INT4612 Positive_regulation of Localization of CGA 64 0.64 8.51 22.39
127 INT139664 Gene_expression of CCL18 83 0.76 37.05 21.95
128 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91
129 INT693 Negative_regulation of Localization of SST 46 0.59 8.57 21.75
130 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51
131 INT116856 Gene_expression of TNFSF10 110 0.75 115.76 21.48
132 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87
133 INT6127 Regulation of Localization of AVP 60 0.62 15.12 20.84
134 INT1792 Positive_regulation of CGA 123 0.70 64.73 20.79
135 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74
136 INT85952 Positive_regulation of AR 168 0.67 64.36 20.66
137 INT15796 Regulation of IL2 66 0.61 25.43 20.62
138 INT78901 Localization of CCL5 67 0.78 40.79 20.59
139 INT57257 Gene_expression of IL7 69 0.62 50.24 20.36
140 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34
141 INT6699 Positive_regulation of ADRA1D 65 0.70 22.72 20.31
142 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
143 INT5048 Binding of Edn1 55 0.47 18.86 19.16
144 INT5372 Localization of LHB 55 0.68 9.47 19
145 INT11628 Regulation of Localization of Pomc 44 0.61 10.46 18.66
146 INT89594 Gene_expression of Ccl5 44 0.54 24.08 18.62
147 INT101988 Positive_regulation of GDF15 71 0.69 51.03 18.56
148 INT167679 Gene_expression of Ccr5 74 0.75 59.03 18.16
149 INT3118 Negative_regulation of Positive_regulation of POMC 33 0.59 9.42 18.07
150 INT71680 Gene_expression of CCL3 43 0.75 33.7 18.01
151 INT7414 Regulation of Localization of SST 31 0.60 4.85 17.46
152 INT36054 Transcription of IL1B 53 0.72 32.64 17.31
153 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92
154 INT213 Negative_regulation of Localization of AVP 46 0.59 19.78 16.79
155 INT6129 Positive_regulation of Localization of AVP 63 0.70 30.44 16.64
156 INT984 Positive_regulation of Localization of GHRH 58 0.70 12.66 16.51
157 INT10918 Gene_expression of ITGB2 93 0.76 71.8 16.34
158 INT10000 Regulation of Gene_expression of IL2 56 0.45 15.33 16.2
159 INT116970 Gene_expression of CCL20 50 0.78 70.54 15.78
160 INT1416 Transcription of POMC 40 0.72 10.71 15.38
161 INT15643 Positive_regulation of Positive_regulation of Pomc 30 0.65 4.59 15.34
162 INT11918 Localization of CGB 35 0.51 8.21 15.01
163 INT89293 Positive_regulation of Gene_expression of CCR5 29 0.70 22.14 15
164 INT153776 Positive_regulation of IL17A 42 0.64 34.58 14.82
165 INT6278 Negative_regulation of Gene_expression of Pomc 35 0.59 11.07 14.8
166 INT9191 Localization of EDN1 94 0.81 57.01 14.78
167 INT94390 Positive_regulation of Gene_expression of GDF15 67 0.69 45.5 14.74
168 INT69952 Positive_regulation of IK 45 0.32 16.08 14.59
169 INT27266 Regulation of Gene_expression of Pomc 41 0.62 6.74 14.59
170 INT7523 Regulation of ADRA1D 42 0.45 11.63 14.52
171 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
172 INT108480 Gene_expression of CCL21 53 0.77 37.87 14.42
173 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35
174 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14
175 INT7413 Positive_regulation of Localization of SST 37 0.69 5.64 13.94
176 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
177 INT6365 Localization of Edn1 56 0.81 18.84 13.83
178 INT50056 Positive_regulation of Dll1 13 0.67 3.16 13.7
179 INT92237 Positive_regulation of Gene_expression of CXCL10 43 0.70 43.67 13.65
180 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63
181 INT172171 Gene_expression of IL15 47 0.37 46.23 13.41
182 INT14572 Binding of INS 205 0.48 175.43 13.38
183 INT20376 Gene_expression of Ccl3 39 0.75 45.42 13.15
184 INT3962 Regulation of AGT 50 0.62 20.96 13.01
185 INT132178 Binding of CD80 41 0.47 15.55 12.98
186 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
187 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79
188 INT51014 Transcription of IL2 42 0.71 21.56 12.7
189 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
190 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39
191 INT7234 Binding of GNRH1 43 0.47 21.59 12.36
192 INT11244 Transcription of CALCA 21 0.69 3.61 12.27
193 INT56883 Positive_regulation of Dll1 8 0.49 3.49 12.25
194 INT3104 Negative_regulation of CGA 76 0.54 29.81 12.23
195 INT120828 Localization of CXCL10 29 0.68 18.01 12.17
196 INT182240 Gene_expression of CXCL13 25 0.59 22.77 11.96
197 INT92574 Gene_expression of CXCL5 51 0.78 24.87 11.89
198 INT5515 Negative_regulation of Positive_regulation of Pomc 25 0.58 8.73 11.88
199 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7
200 INT398 Localization of AGT 45 0.78 16.97 11.54
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