GO:0007268

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Name synaptic transmission
Categary Process
Go Slim No
Go Link GO:0007268
Unique Molecular Interactions 3281
Total Molecular Interactions 4526
Total Single Events 40444
Pain Genes Associated 248

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for synaptic transmission. They are ordered first by their pain relevance and then by number of times they were reported for synaptic transmission. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4
2 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
3 INT10268 Binding of PDYN and POMC 11 0.39 0.08 10.36
4 INT68514 Pnoc Positive_regulation of Oprl1 10 0.59 3.56 9.57
5 INT65724 Binding of Pnoc and Oprl1 8 0.33 2.94 8.82
6 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8
7 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
8 INT126335 Binding of Pax3 and Tac1 6 0.07 6.22 5.27
9 INT44716 Binding of ABL2 and PDYN 2 0.40 0.66 4.77
10 INT296484 Binding of Gria2 and GRIP1 1 0.04 4.52 4.59
11 INT64480 Binding of OPRL1 and PNOC 2 0.33 0.23 4.38
12 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
13 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
14 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9
15 INT130625 Prkcg Regulation of Prkaca 1 0.23 1.32 3.87
16 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
17 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
18 INT115690 Negative_regulation of Prkcg Negative_regulation of Gene_expression of Fos 1 0.47 0.72 3.63
19 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
20 INT108473 Binding of ADCYAP1 and PNOC 1 0.32 0.64 3.41
21 INT212658 KCNA1 Positive_regulation of Cort 1 0.00 2.58 3.36
22 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35
23 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
24 INT276676 Prkcg Regulation of Nav1 1 0.30 0.82 3.29
25 INT182704 Binding of NPFF and TP53INP2 1 0.01 0.73 3.28
26 INT108472 Binding of NOS1 and PNOC 1 0.32 0.64 3.27
27 INT108471 Binding of CALCA and PNOC 1 0.29 0.64 3.25
28 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
29 INT149492 PNOC Negative_regulation of Gene_expression of CCL2 1 0.15 0.68 3.17
30 INT251146 Binding of Grin1 and Dlg2 1 0.36 1.95 3.16
31 INT128513 Pnoc Regulation of Adarb1 1 0.01 0.92 3.14
32 INT161164 Prkcg Regulation of Phosphorylation of Creb1 3 0.41 0.62 3.11
33 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 3 0.00 0.63 3.1
34 INT276679 Prkcg Positive_regulation of Positive_regulation of Nkx1-1 1 0.07 0.94 3.08
35 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
36 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01
37 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
38 INT40660 Pdyn Positive_regulation of Localization of Prl 1 0.27 0 3.01
39 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9
40 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82
41 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79
42 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
43 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
44 INT134294 Binding of Pdyn and Penk 1 0.23 0 2.69
45 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
46 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
47 INT326585 Binding of GYPA and SLC6A3 1 0.13 0.86 2.64
48 INT351444 Grin1 Positive_regulation of Gria2 1 0.22 1.5 2.64
49 INT152113 Binding of NTSR1 and Ngf 3 0.33 2.09 2.62
50 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
51 INT121742 Prkcg Positive_regulation of Ephb1 3 0.49 0.99 2.6
52 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
53 INT70757 Binding of Oprl1 and Pnoc 5 0.03 0.23 2.55
54 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
55 INT69665 Binding of Oprd1 and Pnoc 5 0.35 0.4 2.5
56 INT317528 Ppp1r9b Regulation of Grin1 1 0.18 0.2 2.48
57 INT130284 Ins1 Negative_regulation of Gene_expression of Npy 1 0.32 0.1 2.47
58 INT149494 PNOC Negative_regulation of Gene_expression of CCL5 1 0.19 0.52 2.46
59 INT156799 Gria1 Regulation of Grm8 1 0.11 1.29 2.45
60 INT96462 Pnoc Positive_regulation of Pag1 1 0.01 0.74 2.45
61 INT251147 Binding of Grin2b and Dlg2 1 0.33 2.75 2.43
62 INT96465 Pnoc Positive_regulation of GEM 1 0.01 0.74 2.39
63 INT317526 Binding of Hint1 and Gipc1 1 0.00 0.25 2.38
64 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
65 INT107578 Kitl Negative_regulation of Grin2b 1 0.12 2.05 2.36
66 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35
67 INT107165 Binding of Gabrg1 and Trpv1 2 0.01 0.16 2.34
68 INT96461 Pnoc Positive_regulation of Oprm1 1 0.09 0.73 2.34
69 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
70 INT249013 Gabrg1 Negative_regulation of Per2 1 0.34 0.07 2.31
71 INT76776 Binding of Pnoc and Ptprg 2 0.02 0 2.29
72 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
73 INT91860 Npy Regulation of Npy1r 2 0.28 1.13 2.24
74 INT34310 CRH Positive_regulation of POMC 3 0.42 0.62 2.21
75 INT317524 Binding of Camk2a and Grin1 1 0.17 0.06 2.21
76 INT12140 Ngf Regulation of Chat 1 0.44 1.67 2.18
77 INT39108 Binding of PDYN and YY1 2 0.50 0.44 2.14
78 INT135035 Binding of Hk1 and Tac1 1 0.35 0.18 2.14
79 INT251145 Binding of Grin2a and Dlg2 1 0.31 2.3 2.11
80 INT133946 Binding of DNM2 and OPRK1 1 0.11 0 2.1
81 INT122660 Binding of CACNA1A and DNAH8 2 0.28 2.68 2.08
82 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08
83 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08
84 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
85 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
86 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
87 INT144115 Positive_regulation of Grm5 Positive_regulation of Prkcg 1 0.41 0 2.01
88 INT23755 Mptp1 Regulation of PDYN 1 0.01 2.27 1.98
89 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
90 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
91 INT179445 Vta1 Positive_regulation of Gabrd 1 0.09 0 1.98
92 INT122381 Positive_regulation of Pnoc Positive_regulation of Oprl1 1 0.36 1.11 1.96
93 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
94 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94
95 INT65025 Binding of Oprm1 and Hps4 1 0.01 0 1.93
96 INT264928 Binding of Cnr1 and Hrh1 1 0.01 1.61 1.92
97 INT30146 Binding of Adarb1 and Pdyn 1 0.01 0.17 1.91
98 INT186435 Prkcg Regulation of Creb1 1 0.44 0.45 1.9
99 INT169498 Binding of Oprm1 and Mirlet7a-1 1 0.32 0 1.9
100 INT24942 Calca Regulation of TAC1 1 0.13 0.7 1.89
101 INT153582 Binding of Oprm1 and Hint1 1 0.01 0 1.87
102 INT355251 Cacna1a Regulation of Gene_expression of Gabrg1 1 0.01 0.06 1.86
103 INT211747 Negative_regulation of Binding of Oprm1 and Mors1 1 0.09 0 1.86
104 INT355249 Cacna1a Regulation of Gene_expression of Ltp 1 0.04 0.06 1.86
105 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
106 INT72468 Negative_regulation of Binding of OPRL1 and PNOC 1 0.40 0 1.83
107 INT276669 Negative_regulation of Prkcg Regulation of Nav1 1 0.21 0.68 1.82
108 INT120732 Prkcg Positive_regulation of Phosphorylation of Grin1 2 0.48 1.04 1.81
109 INT169502 Mirlet7a-1 Regulation of Oprm1 1 0.53 0 1.81
110 INT272616 Positive_regulation of Binding of Grin1 and Grin2a 2 0.30 1.36 1.8
111 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
112 INT168925 Binding of Oprm1 and Imraq2 1 0.04 0.13 1.78
113 INT168924 Positive_regulation of Binding of Oprm1 and Imraq2 1 0.06 0.13 1.78
114 INT211746 Binding of Oprm1 and Mors1 1 0.08 0 1.78
115 INT336556 SLC6A3 Positive_regulation of Gene_expression of GOPC 1 0.08 1.87 1.76
116 INT149491 PNOC Negative_regulation of Gene_expression of CD14 1 0.40 0.37 1.76
117 INT139640 Jun Regulation of Gene_expression of Npy 1 0.21 1.98 1.75
118 INT190981 Binding of Npy and Scn2a1 1 0.10 0 1.75
119 INT157524 Binding of GRM5 and OPRM1 1 0.36 0 1.74
120 INT253895 Binding of Htr1b and Htr1d 1 0.40 0.52 1.74
121 INT79365 Pnoc Negative_regulation of Oprl1 2 0.41 0.16 1.72
122 INT80787 Negative_regulation of Binding of Pnoc and Oprl1 2 0.39 0.39 1.72
123 INT139156 Binding of Gria1 and Gria2 1 0.23 0.64 1.72
124 INT6407 Binding of Lama5 and Oprm1 1 0.02 0.08 1.72
125 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
126 INT249005 Gabrg1 Positive_regulation of Per2 1 0.39 0 1.7
127 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
128 INT160304 Npy Regulation of Gene_expression of Fos 3 0.67 1.43 1.68
129 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
130 INT276672 Binding of Prkcg and Nav1 1 0.16 0.18 1.67
131 INT69666 Binding of OPRL1 and Pnoc 2 0.45 0.06 1.66
132 INT276680 Binding of Prkcg and Nkx1-1 1 0.05 0.18 1.66
133 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
134 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
135 INT315180 Gene_expression of Mors1 Positive_regulation of Gene_expression of Oprm1 1 0.03 0.48 1.64
136 INT169441 TAC1 Positive_regulation of Tac1 1 0.01 1.7 1.64
137 INT147258 Binding of Tac1 and Penk 1 0.35 0 1.64
138 INT315181 Gene_expression of Mors1 Positive_regulation of Oprm1 1 0.03 0.48 1.64
139 INT90046 Oprm1 Positive_regulation of P9Ehs1 2 0.16 0.92 1.63
140 INT45816 Binding of Car2 and Gabrg1 2 0.28 0.15 1.63
141 INT199501 Pdyn Positive_regulation of Oprm1 1 0.01 0.86 1.63
142 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
143 INT147652 PLCB1 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.92 1.62
144 INT247281 GLC1N Negative_regulation of HRAS 1 0.02 1.98 1.62
145 INT160578 Binding of CALCA and TAC1 1 0.07 0.91 1.61
146 INT140341 Ngf Positive_regulation of Gene_expression of Oprm1 1 0.02 0.33 1.59
147 INT317558 Binding of Oprm1 and Rgs17 1 0.18 0 1.59
148 INT355254 Ltp Regulation of Cacna1a 1 0.04 0 1.58
149 INT66408 Pomc Positive_regulation of Regulation of HRH1 1 0.01 0 1.58
150 INT40827 Sstr1 Negative_regulation of Localization of Gh1 1 0.13 0 1.58
151 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
152 INT356327 Crh Positive_regulation of Localization of Gabrg1 1 0.17 0 1.58
153 INT128512 Regulation of Pnoc Regulation of Adarb1 1 0.01 0.46 1.58
154 INT254243 Binding of HOMER1 and MRI1 1 0.03 1.99 1.57
155 INT212660 Nr3c1 Regulation of KCNA1 1 0.00 1.25 1.57
156 INT7796 Akr1d1 Regulation of Npy 1 0.03 0 1.57
157 INT168608 Binding of Grin2b and Mmp9 1 0.22 0.41 1.57
158 INT144280 ACP1 Negative_regulation of Phosphorylation of MAPK1 1 0.37 0.78 1.56
159 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
160 INT74843 Binding of Cacna1a and Ea2 3 0.13 3.29 1.55
161 INT148821 Binding of Oprm1 and Grin1 1 0.05 0.24 1.55
162 INT276671 Prkcg Positive_regulation of Nav1 1 0.23 0.21 1.55
163 INT148820 Binding of Oprm1 and Naa15 1 0.02 0.24 1.55
164 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
165 INT73016 PDYN Regulation of TAC1 1 0.29 0.34 1.54
166 INT41101 Mdk Negative_regulation of SST 1 0.02 0 1.53
167 INT111828 UPB1 Positive_regulation of Oprm1 1 0.00 0.85 1.53
168 INT182706 NPFF Regulation of Binding of TP53INP2 1 0.01 0.07 1.52
169 INT140016 Avp Positive_regulation of Gene_expression of Pdyn 1 0.21 0.85 1.52
170 INT260897 CRH Positive_regulation of Localization of IL8 1 0.24 0.09 1.51
171 INT30463 Binding of PDYN and Penk 2 0.01 0 1.5
172 INT121747 Prkcg Negative_regulation of Positive_regulation of Creb1 1 0.16 0.2 1.5
173 INT149743 Ean5 Positive_regulation of Gene_expression of P2rx2 1 0.10 1.54 1.5
174 INT166676 Binding of PRKCA and UGT1A6 1 0.30 0 1.5
175 INT334347 GRP Positive_regulation of Localization of Gabrg1 1 0.19 0 1.5
176 INT69788 Binding of Gpr1 and Pnoc 2 0.09 0 1.49
177 INT117008 Sfpi1 Regulation of Oprm1 1 0.56 0.56 1.49
178 INT8735 Oprm1 Positive_regulation of Scn4a 1 0.00 0 1.49
179 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47
180 INT161865 Mors1 Positive_regulation of Prkcg 1 0.00 0.12 1.47
181 INT39109 Binding of INSRR and PDYN 1 0.15 0.45 1.46
182 INT317509 Oprm1 Negative_regulation of Phosphorylation of Oprd1 1 0.00 0 1.46
183 INT161871 Mors1 Positive_regulation of GRIN1 1 0.01 0.12 1.46
184 INT109958 Binding of CRH and HPSE 1 0.10 0.72 1.46
185 INT12691 SST Negative_regulation of Localization of POMC 3 0.24 1.24 1.45
186 INT83416 Binding of OPRK1 and Ntrk1 1 0.02 0 1.45
187 INT161858 OPRM1 Positive_regulation of GRIN1 1 0.50 0.12 1.45
188 INT29127 Npy Positive_regulation of LH 1 0.47 0 1.45
189 INT153581 Binding of Oprm1 and Prkcg 1 0.00 0 1.44
190 INT19012 Ghsr Negative_regulation of Localization of Sstr1 1 0.10 0 1.44
191 INT84434 Calca Negative_regulation of Negative_regulation of Hrh1 1 0.06 0.19 1.44
192 INT356233 Slc32a1 Positive_regulation of Gabrg1 1 0.17 1.6 1.44
193 INT95325 HTR1B Negative_regulation of Calca 1 0.47 0.69 1.43
194 INT69337 Oprm1 Positive_regulation of Atxn2l 1 0.01 0.27 1.43
195 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43
196 INT246519 Positive_regulation of Grin2b Positive_regulation of Positive_regulation of Ltp 1 0.25 0.08 1.42
197 INT76770 Binding of HTR1E and Gs 1 0.00 0.87 1.42
198 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41
199 INT41591 Binding of PDYN and FAIM3 1 0.00 0 1.41
200 INT128913 Binding of COMT and PENK 1 0.30 0.07 1.41

Single Events

The table below shows the top 100 pain related interactions that have been reported for synaptic transmission. They are ordered first by their pain relevance and then by number of times they were reported in synaptic transmission. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
2 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
3 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41
4 INT5597 Gene_expression of Pdyn 433 0.78 62.97 235.47
5 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
6 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47
7 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74
8 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
9 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65
10 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
11 INT6108 Gene_expression of Npy 292 0.78 110.65 148.21
12 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16
13 INT5595 Positive_regulation of Pdyn 223 0.70 48.37 130.14
14 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34
15 INT5283 Positive_regulation of Npy 191 0.70 66.77 109.2
16 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44
17 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66
18 INT397 Localization of SST 232 0.81 58.05 101.19
19 INT104000 Phosphorylation of Grin2b 73 0.82 48.34 93.48
20 INT9516 Negative_regulation of Gabrg1 149 0.53 27.83 91.02
21 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63
22 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27
23 INT5594 Regulation of Pdyn 137 0.62 27.04 86.63
24 INT6107 Localization of Npy 180 0.81 26.76 81.67
25 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91
26 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37
27 INT5593 Positive_regulation of Gene_expression of Pdyn 114 0.70 29.1 74.46
28 INT12536 Localization of Prkcg 101 0.80 36.37 73.81
29 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42
30 INT442 Localization of PDYN 99 0.81 11.87 72.75
31 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06
32 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
33 INT66416 Regulation of Pnoc 66 0.61 17.32 68.91
34 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26
35 INT39777 Regulation of Prkcg 90 0.62 31.52 68.17
36 INT6824 Regulation of Gene_expression of Pdyn 114 0.62 9.48 66.73
37 INT8347 Gene_expression of SST 181 0.78 104.59 65.45
38 INT66531 Gene_expression of Pnoc 88 0.78 22.9 65.11
39 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9
40 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
41 INT12175 Positive_regulation of PDYN 86 0.69 18.27 62.04
42 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36
43 INT2761 Regulation of Gabrg1 119 0.61 18.8 60.52
44 INT66779 Binding of Pnoc 79 0.48 6.43 60.46
45 INT1430 Regulation of PDYN 88 0.60 16.99 60.32
46 INT65078 Negative_regulation of Pnoc 64 0.59 15.48 59.81
47 INT62960 Gene_expression of P2rx2 149 0.77 58.31 59.16
48 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
49 INT7491 Localization of Pdyn 80 0.81 3.94 58.77
50 INT20964 Gene_expression of OPRK1 96 0.78 23.54 58.18
51 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
52 INT1510 Binding of PDYN 94 0.48 4.68 56.44
53 INT5598 Negative_regulation of Pdyn 95 0.59 14.4 55.43
54 INT6826 Transcription of Pdyn 130 0.71 22.19 54.88
55 INT8071 Positive_regulation of Gria1 102 0.70 26.61 53.37
56 INT6034 Binding of Gabrg1 115 0.47 17.48 51.92
57 INT5118 Regulation of SST 97 0.62 34.35 51.74
58 INT5338 Regulation of Npy 92 0.62 25.54 51.24
59 INT5136 Negative_regulation of PDYN 71 0.59 11.22 51.14
60 INT8690 Localization of Tac1 71 0.80 22.98 50.75
61 INT4985 Positive_regulation of Tac1 81 0.69 35.79 50.67
62 INT19488 Localization of ABAT 56 0.69 21.51 50.56
63 INT10304 Binding of OPRK1 89 0.48 9.28 49.42
64 INT49520 Gene_expression of P2rx3 121 0.78 61.15 49.24
65 INT16850 Negative_regulation of Localization of Gabrg1 73 0.51 8.28 47.89
66 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6
67 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
68 INT5337 Negative_regulation of Npy 87 0.59 19.6 46.75
69 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
70 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
71 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17
72 INT8713 Regulation of Tac1 56 0.60 25.29 45.94
73 INT4776 Localization of TAC1 82 0.78 16.89 45.21
74 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11
75 INT14853 Negative_regulation of Tac1 80 0.59 30.87 45.06
76 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69
77 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52
78 INT4850 Binding of Tac1 57 0.47 14.25 42.17
79 INT64440 Gene_expression of Pnoc 66 0.78 13.61 41.76
80 INT5454 Localization of CRH 124 0.79 79.18 41.53
81 INT66532 Positive_regulation of Pnoc 46 0.70 14.99 41.39
82 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49
83 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43
84 INT6357 Positive_regulation of Localization of Gabrg1 53 0.41 7.03 39.21
85 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
86 INT92515 Gene_expression of Grin2a 84 0.76 26.68 38.37
87 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
88 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14
89 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81
90 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5
91 INT48959 Positive_regulation of Positive_regulation of Prkcg 52 0.70 16.47 36.49
92 INT103172 Gene_expression of Slc12a5 81 0.77 39.45 36.22
93 INT103998 Positive_regulation of Phosphorylation of Grin2b 33 0.69 19.08 36.08
94 INT8837 Positive_regulation of TAC1 59 0.67 21.94 35.97
95 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4
96 INT6943 Positive_regulation of Gabrd 71 0.70 17.36 35.25
97 INT130479 Phosphorylation of Grin2b 28 0.77 34.82 34.97
98 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76
99 INT12765 Positive_regulation of Phosphorylation of Prkcg 59 0.66 20.16 34.67
100 INT692 Negative_regulation of SST 72 0.59 28.68 34.52
101 INT12161 Positive_regulation of P2rx2 70 0.69 34.22 34.4
102 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24
103 INT12537 Positive_regulation of Localization of Prkcg 36 0.70 14.57 33.81
104 INT95789 Positive_regulation of Grm5 42 0.55 20.1 33.72
105 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4
106 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95
107 INT51698 Positive_regulation of Gene_expression of Prkcg 44 0.68 14.02 32.9
108 INT4727 Regulation of TAC1 60 0.47 6.74 32.83
109 INT691 Binding of SST 67 0.48 24.66 32.67
110 INT93451 Positive_regulation of Gene_expression of Grin2b 43 0.70 29.09 31.89
111 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74
112 INT22239 Negative_regulation of TAC1 52 0.57 12.96 31.41
113 INT114173 Phosphorylation of Gria1 27 0.82 33.73 31.24
114 INT49001 Regulation of Gria1 51 0.56 18.28 31.22
115 INT8531 Transcription of PDYN 56 0.72 19.51 30.99
116 INT7845 Regulation of OPRK1 44 0.62 4.54 30.49
117 INT9133 Negative_regulation of Positive_regulation of Prkcg 37 0.59 10.95 30.06
118 INT64918 Gene_expression of Gria2 108 0.74 29.95 29.67
119 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66
120 INT72252 Gene_expression of Kcnma1 63 0.64 20.47 29.56
121 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48
122 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28
123 INT56525 Gene_expression of Gria2 74 0.75 23.15 28.6
124 INT93033 Negative_regulation of Grin2b 48 0.58 20.94 28.54
125 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
126 INT1166 Negative_regulation of Dbh 56 0.59 12.54 28.26
127 INT5097 Localization of Sstr1 30 0.64 0.38 27.92
128 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85
129 INT6594 Gene_expression of HTR1D 60 0.75 10.15 27.13
130 INT51602 Gene_expression of Grm5 59 0.75 17.29 26.99
131 INT72677 Regulation of Gene_expression of Oprm1 45 0.62 13.95 26.75
132 INT11773 Gene_expression of Tac1 56 0.77 10 25.72
133 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64
134 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58
135 INT8779 Binding of TAC1 50 0.47 11.19 25.57
136 INT17925 Transcription of Npy 53 0.72 15.75 25.56
137 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35
138 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2
139 INT107577 Negative_regulation of Grin2b 32 0.59 12.35 24.88
140 INT66417 Localization of Pnoc 34 0.80 1.61 24.48
141 INT5596 Negative_regulation of Gene_expression of Pdyn 41 0.59 5.34 24.36
142 INT12424 Binding of Npy 48 0.48 8.23 24.26
143 INT64076 Positive_regulation of Kcnma1 47 0.40 11.52 24.19
144 INT8380 Positive_regulation of Gene_expression of Npy 49 0.70 19.62 24.13
145 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12
146 INT101225 Positive_regulation of Gria2 62 0.64 28.1 23.93
147 INT48536 Positive_regulation of Grm8 46 0.61 14.31 23.56
148 INT15458 Gene_expression of NPY 50 0.76 22.67 23.03
149 INT9282 Gene_expression of HTR1B 48 0.75 12.15 22.94
150 INT6270 Binding of HTR1D 55 0.47 9.54 22.86
151 INT82461 Gene_expression of Gad2 40 0.78 19.12 22.79
152 INT76249 Gene_expression of Gria1 67 0.75 15.07 22.78
153 INT87607 Positive_regulation of Prkcc 25 0.69 6.06 22.78
154 INT11077 Positive_regulation of Htr3a 63 0.67 15.61 22.7
155 INT57253 Negative_regulation of Binding of Oprm1 24 0.43 5.27 22.67
156 INT51801 Gene_expression of Gabrd 64 0.72 19.17 22.61
157 INT78571 Positive_regulation of Grm5 35 0.69 11.81 22.45
158 INT16851 Regulation of Localization of Gabrg1 34 0.39 4.34 22.29
159 INT9988 Regulation of Hrh1 22 0.46 12.87 22.13
160 INT693 Negative_regulation of Localization of SST 46 0.59 8.57 21.75
161 INT3382 Positive_regulation of Dbh 33 0.70 11.64 21.67
162 INT49623 Negative_regulation of Gria1 39 0.59 12.4 21.59
163 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05
164 INT129987 Phosphorylation of Gria1 63 0.80 20.65 21.02
165 INT102281 Positive_regulation of Gene_expression of Grin2b 27 0.70 10.38 20.84
166 INT103169 Negative_regulation of Slc12a5 38 0.58 27.75 20.81
167 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78
168 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48
169 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41
170 INT49835 Negative_regulation of Positive_regulation of Oprm1 21 0.42 4.11 20.11
171 INT47876 Binding of Pnoc 20 0.47 4.99 20.01
172 INT14436 Gene_expression of Dbh 42 0.72 9.9 19.85
173 INT9782 Binding of HTR1B 43 0.47 12.08 19.83
174 INT10118 Positive_regulation of Localization of Pdyn 15 0.70 0.77 19.5
175 INT135629 Binding of COMT 33 0.48 16.68 19.37
176 INT11243 Localization of NPY 33 0.78 11.18 19.24
177 INT68970 Positive_regulation of Pnoc 33 0.67 9.29 19.08
178 INT91916 Gene_expression of P2rx3 51 0.78 21.2 19.05
179 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99
180 INT2960 Regulation of Dbh 32 0.47 10.32 18.94
181 INT107930 Gene_expression of Slc17a7 39 0.78 6.53 18.86
182 INT90612 Positive_regulation of Grin2a 33 0.65 15.11 18.84
183 INT33327 Positive_regulation of Gene_expression of Gabrg1 39 0.69 9.68 18.82
184 INT9230 Gene_expression of Htr3a 43 0.78 10.54 18.81
185 INT11524 Negative_regulation of Gabrd 39 0.58 6.25 18.8
186 INT6807 Regulation of Gabrd 39 0.62 9.22 18.74
187 INT30312 Binding of Pdyn 30 0.37 4.2 18.23
188 INT18621 Binding of ABAT 28 0.36 9.88 18.04
189 INT12360 Regulation of Tac1 31 0.61 5.9 18
190 INT29709 Positive_regulation of Gene_expression of Gria1 36 0.69 9.43 17.83
191 INT21132 Gene_expression of GABRB3 36 0.33 11.32 17.61
192 INT63928 Negative_regulation of Grin1 51 0.56 11.81 17.57
193 INT9358 Positive_regulation of HTR1B 26 0.67 11 17.51
194 INT7644 Positive_regulation of Gene_expression of PDYN 27 0.69 10.19 17.47
195 INT7414 Regulation of Localization of SST 31 0.60 4.85 17.46
196 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35
197 INT68640 Regulation of Pnoc 18 0.54 7.6 17.27
198 INT78233 Positive_regulation of P2rx3 36 0.56 21.49 17.25
199 INT95930 Negative_regulation of Gria2 63 0.56 18.37 17.04
200 INT48055 Gene_expression of Grm1 27 0.78 14.29 17.01
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