GO:0007270

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Name neuron-neuron synaptic transmission
Categary Process
Go Slim No
Go Link GO:0007270
Unique Molecular Interactions 133
Total Molecular Interactions 178
Total Single Events 1693
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for neuron-neuron synaptic transmission. They are ordered first by their pain relevance and then by number of times they were reported for neuron-neuron synaptic transmission. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
2 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
3 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
4 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
5 INT355251 Cacna1a Regulation of Gene_expression of Gabrg1 1 0.01 0.06 1.86
6 INT355249 Cacna1a Regulation of Gene_expression of Ltp 1 0.04 0.06 1.86
7 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
8 INT355254 Ltp Regulation of Cacna1a 1 0.04 0 1.58
9 INT74843 Binding of Cacna1a and Ea2 3 0.13 3.29 1.55
10 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
11 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
12 INT355250 Ltp Regulation of Positive_regulation of Cacna1a 1 0.04 0 1.39
13 INT355253 Ltp Positive_regulation of Cacna1a 1 0.05 0 1.34
14 INT355252 Binding of Cacna1a and Cnr1 1 0.04 0 1.31
15 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
16 INT74841 Binding of Cacna1a and Ea2 2 0.01 2.33 1.27
17 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
18 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
19 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
20 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1
21 INT108729 Binding of CACNA1A and Cacna1a 3 0.13 1.21 0.95
22 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
23 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86
24 INT36008 Negative_regulation of Binding of Drd2 and Prl 1 0.01 2.11 0.85
25 INT182839 Camk4 Positive_regulation of Creb1 3 0.49 1.81 0.79
26 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77
27 INT116803 Phosphorylation of Camk2b Positive_regulation of Camk4 1 0.03 0 0.76
28 INT334833 Binding of Drd2 and Ncs1 1 0.05 1.11 0.76
29 INT151339 Positive_regulation of Binding of Drd2 and P9Ehs1 1 0.11 0.22 0.76
30 INT151340 Binding of Drd2 and P9Ehs1 1 0.09 0.22 0.75
31 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
32 INT31416 Cacna1a Positive_regulation of Gene_expression of Gcg 1 0.03 0 0.65
33 INT335591 Binding of Camk4 and Ltp 1 0.30 0 0.65
34 INT335588 Positive_regulation of Binding of Camk4 and Ltp 1 0.39 0 0.65
35 INT335595 Camk4 Regulation of Fam82b 1 0.04 0.48 0.64
36 INT209131 Binding of Bcl2a1a and Drd2 1 0.22 0.45 0.62
37 INT335590 Camk4 Regulation of Ablim1 1 0.04 0.48 0.62
38 INT45258 SLAMF6 Positive_regulation of Drd2 1 0.00 0 0.55
39 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
40 INT271889 Binding of DRD2 and ANKK1 1 0.23 0.36 0.55
41 INT296273 Prkaca Regulation of Localization of Camk4 1 0.16 0.62 0.55
42 INT271888 Binding of DRD2 and DNAJC7 1 0.14 0.36 0.55
43 INT221783 Nlrp1a Negative_regulation of Camk4 1 0.08 1.39 0.55
44 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54
45 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
46 INT25414 Positive_regulation of Drd2 Positive_regulation of Penk 1 0.38 0 0.53
47 INT165045 Drd2 Regulation of Cpe 1 0.07 0 0.52
48 INT165042 Drd2 Regulation of Tac1 1 0.22 0 0.52
49 INT335589 Camk4 Regulation of Ltp 1 0.38 0.42 0.52
50 INT165043 Drd2 Regulation of Cck 1 0.20 0 0.52
51 INT20580 Drd2 Regulation of Akr1d1 1 0.02 0.26 0.51
52 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51
53 INT354986 Cacna1a Regulation of Localization of Mpo 1 0.01 1.15 0.49
54 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
55 INT16586 Binding of Drd2 and Nts 1 0.12 0 0.43
56 INT89666 Binding of Adora2a and Drd2 1 0.54 0.4 0.42
57 INT36009 Binding of Drd2 and Prl 1 0.01 1.05 0.42
58 INT186148 Camk4 Positive_regulation of Phosphorylation of Creb1 2 0.50 1.11 0.4
59 INT354984 Binding of Cacna1a and Tnf 1 0.01 0.83 0.4
60 INT55588 Drd2 Regulation of Transcription of Gad1 1 0.15 0.07 0.4
61 INT55589 Drd2 Regulation of Gad1 1 0.15 0.07 0.4
62 INT334835 Negative_regulation of Binding of Drd2 and Ncs1 1 0.04 0.56 0.38
63 INT158355 Cacna1a Regulation of Alox5 1 0.01 0.7 0.37
64 INT37247 Binding of Drd1a and Drd2 1 0.20 0 0.37
65 INT327708 Binding of Drd1a and Drd2 1 0.12 0.12 0.37
66 INT151544 Camk4 Positive_regulation of Regulation of Fmr1 1 0.50 0.36 0.37
67 INT151551 Regulation of Camk4 Positive_regulation of Atf2 1 0.34 0.36 0.37
68 INT151547 Camk4 Positive_regulation of Atf2 1 0.38 0.36 0.37
69 INT127887 SLC6A3 Regulation of Drd2 1 0.34 0.68 0.34
70 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34
71 INT354982 Cacna1a Regulation of Tnf 1 0.00 0.73 0.34
72 INT334836 Ncs1 Regulation of Drd2 1 0.02 0.48 0.33
73 INT109894 Drd2 Positive_regulation of FOS 1 0.01 0 0.33
74 INT151258 Binding of Cacna1a and FCMTE1 1 0.00 0.57 0.3
75 INT186152 Camk4 Regulation of Phosphorylation of Creb1 3 0.27 0.44 0.29
76 INT273130 Negative_regulation of Binding of Drd2 and Hp 1 0.05 0 0.28
77 INT273129 Binding of Drd2 and Hp 1 0.04 0 0.28
78 INT97594 Penk Regulation of Gene_expression of Drd2 1 0.15 0.1 0.28
79 INT296281 Calm3 Regulation of Localization of Camk4 1 0.13 0.31 0.28
80 INT296302 Camk4 Regulation of Localization of Calm3 1 0.15 0.31 0.28
81 INT296287 Camk4 Regulation of Positive_regulation of Creb1 1 0.27 0.31 0.27
82 INT142003 Binding of Cacna1a and Etax2 1 0.00 1.02 0.26
83 INT142004 Binding of Cacna1a and TGM6 1 0.00 1.02 0.26
84 INT186151 Camk4 Regulation of Creb1 2 0.27 1.06 0.25
85 INT258757 Binding of Drd2 and Rends1 1 0.00 1.26 0.25
86 INT186149 Camk4 Positive_regulation of Crem 1 0.27 0.8 0.23
87 INT221781 Camk4 Positive_regulation of Mef2d 1 0.28 0.14 0.22
88 INT164136 Binding of DRD2 and Prl 1 0.09 0 0.22
89 INT164135 Binding of Drd2 and Prl 1 0.04 0 0.22
90 INT202252 COMT Regulation of DRD2 1 0.31 0 0.21
91 INT186150 Camk4 Regulation of Gene_expression of Oxt 1 0.20 1.24 0.2
92 INT69254 Drd2 Regulation of Gene_expression of Pomc 1 0.01 0 0.2
93 INT221785 Camk4 Positive_regulation of Atf1 1 0.12 0.14 0.19
94 INT71329 Cacna1a Regulation of Ea2 1 0.01 0.71 0.15
95 INT71328 Cacna1a Regulation of Atxn2 1 0.00 0.71 0.15
96 INT224129 Binding of DRD2 and Adora2a 1 0.03 0.19 0.14
97 INT227956 Drd2 Regulation of Chrm2 1 0.07 0.38 0.13
98 INT227957 Chrm4 Regulation of Localization of Drd2 1 0.19 0.38 0.13
99 INT227960 Drd2 Regulation of Chrm5 1 0.26 0.38 0.13
100 INT227958 Chrm2 Regulation of Localization of Drd2 1 0.17 0.38 0.13
101 INT227959 Drd2 Regulation of Chrm4 1 0.08 0.38 0.13
102 INT202255 Binding of DRD2 and TCN1 1 0.16 0 0.12
103 INT258767 Binding of Drd2 and ADHD1 1 0.11 1.14 0.11
104 INT120559 Binding of Cacna1a and FCMTE1 1 0.02 0.25 0.1
105 INT194825 Camk4 Positive_regulation of CREB1 1 0.01 0 0.1
106 INT194837 Camk4 Positive_regulation of TFAM 1 0.00 0 0.1
107 INT8046 SORT1 Negative_regulation of Drd2 1 0.00 0 0.09
108 INT221258 Negative_regulation of Binding of VDAC1 and Crk 1 0.00 0.22 0.08
109 INT221782 Camk4 Regulation of Binding of ras 1 0.05 0.45 0.08
110 INT221255 Binding of VDAC1 and Crk 1 0.00 0.22 0.08
111 INT267776 Binding of Vdac3 and IgG 1 0.01 0.69 0.08
112 INT258768 Drd2 Regulation of ADHD1 1 0.14 0.79 0.07
113 INT244092 Binding of C2 and Drd2 1 0.01 0.06 0.07
114 INT202893 Camk4 Negative_regulation of Grin1 1 0.10 0.17 0.05
115 INT327711 Binding of Drd2 and Uts2r 1 0.07 0.41 0.04
116 INT354983 Cacna1a Regulation of Mpo 1 0.02 0.41 0.04
117 INT186147 Camk4 Regulation of Regulation of Creb1 1 0.45 0.95 0.04
118 INT354987 Cacna1a Regulation of Localization of LDHA 1 0.00 0.23 0.03
119 INT277243 Camk4 Regulation of Regulation of aicda 1 0.04 0.42 0.03
120 INT322667 Binding of Vdac1 and Pbrm1 1 0.15 0.79 0.03
121 INT316995 Binding of Camk4 and Slc43a3 1 0.04 0.67 0.03
122 INT215349 Binding of VDAC1 and Tspo 1 0.00 0.63 0
123 INT202571 Binding of DRD2 and DRD4 1 0.41 0.76 0
124 INT261963 Binding of Cacna1a and Tgm2 1 0.08 1.19 0
125 INT250496 Gopc Regulation of Positive_regulation of Cacna1a 1 0.37 0 0
126 INT298754 Binding of CALM1 and Camk4 1 0.01 1.19 0
127 INT215344 Binding of Sp1 and Vdac1 1 0.02 0.1 0
128 INT69257 Drd2 Regulation of Gene_expression of Cpe 1 0.06 0 0
129 INT69256 Drd2 Regulation of Regulation of Pomc 1 0.29 0 0
130 INT202892 Chrm3 Regulation of Negative_regulation of Camk4 1 0.02 0.37 0
131 INT69255 Drd2 Regulation of Transcription of Pomc 1 0.29 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for neuron-neuron synaptic transmission. They are ordered first by their pain relevance and then by number of times they were reported in neuron-neuron synaptic transmission. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
2 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
3 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
4 INT13501 Binding of Drd2 65 0.48 23.76 35.6
5 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
6 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
7 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
8 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2
9 INT12484 Binding of Drd2 45 0.48 15.17 24.72
10 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
11 INT121872 Gene_expression of Camk4 156 0.78 70.47 21.39
12 INT49774 Binding of DRD2 48 0.48 17.42 20.73
13 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35
14 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
15 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
16 INT30101 Regulation of Cacna1a 25 0.45 14.38 12.43
17 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91
18 INT118676 Positive_regulation of Camk4 34 0.70 16.67 10.9
19 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
20 INT118678 Phosphorylation of Camk4 22 0.82 9.4 10.7
21 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
22 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
23 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
24 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
25 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
26 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
27 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
28 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
29 INT24460 Localization of Drd2 12 0.73 2.96 6.46
30 INT91821 Binding of Cacna1a 16 0.48 13.1 6.37
31 INT86772 Localization of Drd2 14 0.80 1.93 6.17
32 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
33 INT121870 Positive_regulation of Gene_expression of Camk4 24 0.70 15.63 5.83
34 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
35 INT118673 Regulation of Camk4 12 0.48 7.92 5.22
36 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
37 INT129508 Localization of Cacna1a 7 0.74 6.47 5.13
38 INT158669 Negative_regulation of Camk4 43 0.58 26.82 5.04
39 INT110796 Positive_regulation of Positive_regulation of Cacna1a 1 0.49 0.51 4.84
40 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
41 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
42 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
43 INT82731 Transcription of Cacna1a 5 0.56 3.41 4.27
44 INT121871 Localization of Camk4 9 0.81 4.67 3.84
45 INT121740 Negative_regulation of Camk4 1 0.26 0.2 3.36
46 INT94045 Regulation of Cacna1a 5 0.42 3.56 3.33
47 INT116802 Regulation of Camk4 4 0.20 1.77 3.29
48 INT121865 Regulation of Gene_expression of Camk4 8 0.54 2.65 3.23
49 INT102209 Negative_regulation of Gene_expression of Drd2 5 0.59 0.46 3.17
50 INT85572 Gene_expression of Cacna1a 11 0.66 5.72 3.02
51 INT142940 Positive_regulation of Negative_regulation of Cacna1a 3 0.50 1.65 2.97
52 INT118675 Positive_regulation of Phosphorylation of Camk4 5 0.66 1.58 2.93
53 INT355244 Negative_regulation of Negative_regulation of Cacna1a 1 0.04 0 2.67
54 INT108468 Negative_regulation of Gene_expression of Drd2 3 0.41 0.67 2.58
55 INT103881 Positive_regulation of Binding of DRD2 4 0.69 2.01 2.18
56 INT155347 Negative_regulation of Phosphorylation of Camk4 1 0.41 4.16 2.1
57 INT110795 Regulation of Positive_regulation of Cacna1a 2 0.26 0.65 2.07
58 INT25411 Positive_regulation of Positive_regulation of Drd2 2 0.48 0.5 1.98
59 INT354979 Positive_regulation of Localization of Cacna1a 2 0.05 0.86 1.79
60 INT355239 Negative_regulation of Positive_regulation of Cacna1a 1 0.04 0 1.79
61 INT71327 Localization of Cacna1a 3 0.60 2.51 1.7
62 INT152172 Gene_expression of Camk4 2 0.58 0.18 1.61
63 INT355242 Negative_regulation of Binding of Cacna1a 1 0.04 0.17 1.47
64 INT355245 Regulation of Localization of Cacna1a 1 0.04 0 1.43
65 INT75062 Regulation of Transcription of Drd2 1 0.51 0 1.41
66 INT90740 Negative_regulation of Cacna1a 3 0.23 1.43 1.38
67 INT127496 Negative_regulation of Gene_expression of Camk4 9 0.43 2.66 1.32
68 INT109272 Negative_regulation of Binding of DRD2 2 0.36 0.76 1.26
69 INT15663 Regulation of Transcription of Drd2 2 0.26 0.1 1.25
70 INT82727 Positive_regulation of Transcription of Cacna1a 1 0.01 1.07 1.25
71 INT118677 Positive_regulation of Positive_regulation of Camk4 3 0.33 0.83 1.24
72 INT77216 Localization of DRD2 3 0.75 0 1.19
73 INT85571 Positive_regulation of Cacna1a 3 0.50 2.06 1.18
74 INT355243 Negative_regulation of Regulation of Cacna1a 1 0.04 0 1.16
75 INT202579 Regulation of Gene_expression of DRD2 4 0.41 1.11 0.99
76 INT182834 Positive_regulation of Localization of Camk4 2 0.50 0.67 0.99
77 INT114136 Binding of Vdac1 3 0.47 2.02 0.97
78 INT321650 Negative_regulation of Gene_expression of Cacna1a 2 0.04 0.13 0.95
79 INT94046 Protein_catabolism of Cacna1a 1 0.70 0.83 0.9
80 INT11086 Regulation of Positive_regulation of Drd2 2 0.45 1.22 0.84
81 INT123286 Transcription of Camk4 1 0.04 0.55 0.81
82 INT13692 Negative_regulation of Positive_regulation of Drd2 1 0.01 0 0.79
83 INT103879 Regulation of Binding of DRD2 1 0.23 0.13 0.79
84 INT16434 Regulation of Positive_regulation of Drd2 1 0.30 0 0.78
85 INT12885 Negative_regulation of Binding of Drd2 2 0.53 0.26 0.71
86 INT326603 Regulation of Positive_regulation of DRD2 1 0.44 0.8 0.69
87 INT15662 Positive_regulation of Transcription of Drd2 3 0.39 0 0.68
88 INT103336 Transcription of Cacna1a 2 0.69 1.17 0.68
89 INT184840 Positive_regulation of Transcription of Drd2 2 0.35 1.03 0.65
90 INT221223 Phosphorylation of VDAC1 1 0.01 1.16 0.63
91 INT12483 Regulation of Binding of Drd2 1 0.38 0 0.57
92 INT47933 Positive_regulation of Localization of Drd2 1 0.10 0.23 0.56
93 INT47934 Negative_regulation of Localization of Drd2 1 0.10 0.22 0.56
94 INT114138 Gene_expression of Vdac1 18 0.59 7.07 0.53
95 INT114139 Gene_expression of Vdac3 1 0.46 0 0.53
96 INT114143 Negative_regulation of Vdac3 2 0.39 0.85 0.47
97 INT202581 Positive_regulation of Gene_expression of DRD2 2 0.49 0.81 0.47
98 INT66984 Regulation of Binding of Drd2 1 0.60 0 0.47
99 INT99962 Positive_regulation of Gene_expression of Cacna1a 1 0.01 1.1 0.34
100 INT215348 Binding of VDAC1 1 0.01 1.43 0.33
101 INT202873 Positive_regulation of Negative_regulation of Camk4 5 0.40 1.7 0.31
102 INT215347 Regulation of VDAC1 1 0.01 0.13 0.27
103 INT215322 Positive_regulation of Vdac1 1 0.10 1.06 0.27
104 INT326600 Negative_regulation of Gene_expression of DRD2 1 0.53 0.35 0.23
105 INT224096 Positive_regulation of Negative_regulation of DRD2 1 0.05 0.38 0.15
106 INT221222 Localization of VDAC1 1 0.01 0.25 0.09
107 INT202864 Negative_regulation of Positive_regulation of Camk4 2 0.27 0.83 0.06
108 INT232495 Gene_expression of VDAC1 1 0.06 0.64 0.06
109 INT309389 Phosphorylation of Cacna1a 1 0.01 0.54 0.05
110 INT309386 Positive_regulation of Phosphorylation of Cacna1a 1 0.01 0.54 0.05
111 INT322643 Localization of Vdac1 1 0.33 0.91 0.03
112 INT322645 Positive_regulation of Localization of Vdac1 1 0.22 0.93 0.03
113 INT215327 Positive_regulation of Gene_expression of Vdac1 12 0.16 5.79 0
114 INT215335 Regulation of Positive_regulation of Vdac1 1 0.07 0.17 0
115 INT215330 Positive_regulation of Transcription of Vdac1 1 0.07 0.28 0
116 INT337102 Protein_catabolism of Drd2 1 0.88 0 0
117 INT221217 Negative_regulation of Vdac1 1 0.18 0.93 0
118 INT315124 Protein_catabolism of VDAC1 1 0.49 0.48 0
119 INT202862 Regulation of Negative_regulation of Camk4 1 0.14 0.46 0
120 INT298753 Binding of Camk4 1 0.31 0.53 0
121 INT215320 Regulation of Vdac1 1 0.07 0.21 0
122 INT215329 Transcription of Vdac1 1 0.10 0.28 0
123 INT115017 Positive_regulation of Camk4 1 0.49 0 0
124 INT263506 Regulation of Regulation of Drd2 1 0.26 0.34 0
125 INT202859 Negative_regulation of Negative_regulation of Camk4 1 0.22 0.1 0
126 INT215338 Regulation of Gene_expression of Vdac1 1 0.04 0.56 0
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