GO:0007339

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Name binding of sperm to zona pellucida
Categary Process
Go Slim No
Go Link GO:0007339
Unique Molecular Interactions 67
Total Molecular Interactions 104
Total Single Events 346
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for binding of sperm to zona pellucida. They are ordered first by their pain relevance and then by number of times they were reported for binding of sperm to zona pellucida. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT322411 Hist1h1t Positive_regulation of Positive_regulation of OPRM1 1 0.00 1.25 3.63
2 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
3 INT322410 Hist1h1t Positive_regulation of Phosphorylation of OPRM1 1 0.00 0.08 2.31
4 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
5 INT174450 Positive_regulation of Binding of Cxcr3 and Smcp 1 0.18 2.83 1.49
6 INT350862 Hist1h1t Regulation of Kcnj5 1 0.02 1.35 1.22
7 INT124742 ARSA Positive_regulation of Localization of CSF2 1 0.10 0.15 0.91
8 INT124743 ARSA Negative_regulation of PTGER2 1 0.03 0.15 0.85
9 INT124744 ARSA Negative_regulation of Gene_expression of PTGER2 1 0.03 0.15 0.85
10 INT174454 Binding of Cxcr3 and Smcp 1 0.14 1.41 0.74
11 INT174455 Smcp Positive_regulation of Gene_expression of Cxcr3 1 0.17 1.31 0.71
12 INT302642 Binding of ARSA and TGFB1 1 0.05 0.28 0.68
13 INT125543 Arsa Negative_regulation of Phosphorylation of Nfkbia 1 0.00 0.52 0.68
14 INT174453 Smcp Positive_regulation of Cxcr3 1 0.17 1.29 0.64
15 INT94075 ARSA Negative_regulation of Gene_expression of IL4 1 0.28 0.26 0.62
16 INT350859 Hist1h1t Regulation of Gene_expression of Kcnj5 1 0.02 0.37 0.59
17 INT125546 Arsa Negative_regulation of Gene_expression of PTGS2 1 0.00 0.53 0.58
18 INT350861 Hist1h1t Positive_regulation of Gene_expression of Kcnj5 1 0.02 0.35 0.56
19 INT302645 ARSA Positive_regulation of Gene_expression of TGFB1 1 0.08 0.28 0.55
20 INT302644 ARSA Positive_regulation of Gene_expression of TGFBR1 1 0.04 0.29 0.51
21 INT302647 ARSA Positive_regulation of TGFBR1 1 0.03 0.29 0.51
22 INT350860 Hist1h1t Positive_regulation of Kcnj5 1 0.02 0.54 0.5
23 INT302643 ARSA Positive_regulation of Localization of TGFB1 1 0.08 0.12 0.49
24 INT322396 Hist1h1t Positive_regulation of Akt1 1 0.01 0 0.42
25 INT322394 Hist1h1t Positive_regulation of Pik3cb 1 0.01 0 0.42
26 INT207110 Adam3 Regulation of Gene_expression of Eef1a1 1 0.01 1 0.41
27 INT273893 ARSA Positive_regulation of HSD11B1 1 0.00 0.61 0.4
28 INT280190 Cbs Regulation of Gene_expression of Hist1h1t 1 0.04 0.58 0.32
29 INT94073 ARSA Negative_regulation of Transcription of IL4 1 0.20 0.16 0.31
30 INT94076 ARSA Negative_regulation of Gene_expression of IL2 1 0.13 0.09 0.3
31 INT94072 ARSA Regulation of Gene_expression of IL2 1 0.07 0.09 0.29
32 INT349537 Smcp Positive_regulation of Tnfsf10 1 0.38 3.48 0.28
33 INT94074 ARSA Regulation of Gene_expression of IK 1 0.01 0.06 0.27
34 INT184192 IL1B Positive_regulation of SPAM1 1 0.04 0.49 0.24
35 INT184191 IL1B Positive_regulation of Gene_expression of SPAM1 1 0.03 0.59 0.23
36 INT299155 Smcp Negative_regulation of Spp1 1 0.00 0.7 0.22
37 INT299156 Smcp Negative_regulation of Tnc 1 0.05 0.7 0.22
38 INT299154 Smcp Negative_regulation of Lgals3 1 0.04 0.69 0.22
39 INT349538 Smcp Positive_regulation of Positive_regulation of Casp9 1 0.04 0.68 0.18
40 INT349539 Smcp Positive_regulation of Positive_regulation of Casp8 1 0.04 0.68 0.18
41 INT184194 Binding of HRAS and SPAM1 1 0.00 0.26 0.17
42 INT278265 Binding of Fgf2 and Smcp 1 0.03 0.26 0.14
43 INT350909 Binding of Pcsk4 and Twist1 1 0.02 1.91 0.08
44 INT38206 Acr Negative_regulation of Txnrd1 1 0.20 0.08 0.08
45 INT350905 Binding of Bcl2 and Pcsk4 1 0.03 0.96 0.04
46 INT106380 ARSA Regulation of Gene_expression of BAX 1 0.06 0.12 0
47 INT278264 Gene_expression of Ntf3 Positive_regulation of Smcp 1 0.02 0.32 0
48 INT349530 Tnfsf10 Negative_regulation of Smcp 1 0.28 0.88 0
49 INT349535 Binding of Smcp and Tnfsf10 1 0.36 6.79 0
50 INT184195 IL1B Regulation of Gene_expression of SPAM1 1 0.02 0 0
51 INT349532 Positive_regulation of Binding of Smcp and Tnfsf10 1 0.35 2.16 0
52 INT168759 Hist1h1t Positive_regulation of Positive_regulation of Oprm1 1 0.02 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for binding of sperm to zona pellucida. They are ordered first by their pain relevance and then by number of times they were reported in binding of sperm to zona pellucida. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT147366 Gene_expression of Hist1h1t 15 0.44 9.84 6.67
2 INT174423 Gene_expression of Smcp 39 0.48 29.45 6.06
3 INT38204 Gene_expression of Acr 4 0.66 4.23 2.85
4 INT149507 Positive_regulation of Hist1h1t 4 0.26 2.71 2.33
5 INT174446 Positive_regulation of Smcp 7 0.33 5.47 2.24
6 INT174415 Transcription of Smcp 1 0.23 3.52 1.9
7 INT280198 Regulation of Hist1h1t 2 0.21 1.28 1.69
8 INT322389 Phosphorylation of Hist1h1t 1 0.03 0 1.67
9 INT302658 Binding of ARSA 1 0.07 0.92 1.53
10 INT174434 Localization of Smcp 6 0.53 2.45 1.46
11 INT181856 Gene_expression of SPAM1 2 0.22 4.5 1.35
12 INT103527 Positive_regulation of Smcp 5 0.41 2.25 1.26
13 INT43295 Regulation of Arsa 1 0.43 0 1.15
14 INT280196 Positive_regulation of Gene_expression of Hist1h1t 1 0.07 1.62 1.02
15 INT174424 Binding of Smcp 9 0.25 2.68 0.94
16 INT104298 Negative_regulation of ARSA 2 0.28 0.56 0.89
17 INT278254 Positive_regulation of Localization of Smcp 1 0.24 0 0.85
18 INT176467 Gene_expression of Arsa 1 0.58 2.62 0.83
19 INT96649 Gene_expression of ARSA 5 0.65 2.82 0.8
20 INT302660 Positive_regulation of Gene_expression of ARSA 1 0.10 0.88 0.77
21 INT125542 Phosphorylation of Arsa 1 0.02 0.52 0.67
22 INT147195 Negative_regulation of Smcp 4 0.38 3.53 0.65
23 INT280195 Regulation of Gene_expression of Hist1h1t 1 0.04 1.09 0.63
24 INT179362 Gene_expression of Smcp 5 0.54 4.5 0.52
25 INT104297 Regulation of ARSA 1 0.18 1.05 0.49
26 INT302661 Negative_regulation of Negative_regulation of ARSA 1 0.08 0.13 0.44
27 INT116427 Negative_regulation of Smcp 10 0.31 2.72 0.41
28 INT278253 Positive_regulation of Gene_expression of Smcp 3 0.29 1.24 0.39
29 INT128155 Regulation of Smcp 3 0.23 0.89 0.39
30 INT184203 Regulation of SPAM1 2 0.17 1.43 0.39
31 INT207107 Positive_regulation of Adam3 1 0.39 0.96 0.39
32 INT184197 Localization of SPAM1 1 0.21 1.49 0.39
33 INT302663 Positive_regulation of ARSA 1 0.10 0.36 0.38
34 INT174440 Negative_regulation of Positive_regulation of Smcp 1 0.14 0.65 0.32
35 INT174436 Positive_regulation of Negative_regulation of Smcp 1 0.15 0.65 0.32
36 INT184205 Binding of SPAM1 3 0.09 0.86 0.31
37 INT280192 Negative_regulation of Gene_expression of Hist1h1t 1 0.04 0.54 0.27
38 INT48473 Binding of Smcp 5 0.31 5.14 0.24
39 INT59964 Localization of Pcsk4 3 0.59 2.25 0.23
40 INT184202 Transcription of SPAM1 1 0.15 0.75 0.2
41 INT149506 Negative_regulation of Hist1h1t 2 0.30 0.83 0.18
42 INT184198 Positive_regulation of Gene_expression of SPAM1 1 0.14 0.42 0.18
43 INT182865 Localization of ARSA 1 0.24 1.27 0.15
44 INT50051 Regulation of Pcsk4 2 0.24 1.07 0.13
45 INT244122 Negative_regulation of Arsa 1 0.42 0 0.12
46 INT3649 Positive_regulation of Arsa 1 0.50 0 0.1
47 INT104405 Positive_regulation of Acr 3 0.28 0.47 0.09
48 INT278252 Regulation of Smcp 2 0.29 1.58 0.09
49 INT184201 Positive_regulation of SPAM1 1 0.13 0.26 0.08
50 INT350856 Localization of Hist1h1t 1 0.34 0.35 0.03
51 INT319365 Regulation of Gene_expression of Smcp 3 0.32 0.53 0
52 INT38205 Negative_regulation of Acr 3 0.50 0.1 0
53 INT59962 Gene_expression of Pcsk4 2 0.49 3 0
54 INT130131 Regulation of Acr 2 0.11 0.2 0
55 INT319367 Negative_regulation of Gene_expression of Smcp 2 0.30 0.71 0
56 INT179206 Binding of Acr 1 0.21 0 0
57 INT184199 Positive_regulation of Localization of SPAM1 1 0.13 0 0
58 INT97888 Localization of Acr 1 0.11 0 0
59 INT350901 Positive_regulation of Pcsk4 1 0.08 1.59 0
60 INT59963 Transcription of Pcsk4 1 0.39 0 0
61 INT349527 Phosphorylation of Smcp 1 0.58 1.93 0
62 INT336963 Localization of Smcp 1 0.04 1.61 0
63 INT184207 Protein_catabolism of SPAM1 1 0.24 0 0
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