GO:0007368

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Name determination of left/right symmetry
Categary Process
Go Slim No
Go Link GO:0007368
Unique Molecular Interactions 217
Total Molecular Interactions 302
Total Single Events 1499
Pain Genes Associated 37

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for determination of left/right symmetry. They are ordered first by their pain relevance and then by number of times they were reported for determination of left/right symmetry. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT250867 Fgf8 Positive_regulation of Protein_catabolism of Ecm1 1 0.06 4.35 2.14
2 INT151889 Binding of Adarb1 and DLL1 1 0.00 0 1.66
3 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
4 INT274948 Binding of Dh and Ltp 1 0.11 0.55 1.23
5 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
6 INT250868 Fgf8 Positive_regulation of Gene_expression of Mmp3 1 0.15 1.73 0.93
7 INT52761 Dll1 Regulation of Sptan1 1 0.07 0 0.89
8 INT52762 Dll1 Regulation of Drd1a 1 0.10 0 0.89
9 INT250861 Fgf8 Positive_regulation of Gene_expression of Ptger2 1 0.04 1.51 0.84
10 INT266102 Binding of PITX2 and RS1 1 0.00 0.64 0.8
11 INT151882 Binding of YY1 and DLL1 1 0.00 0 0.79
12 INT151883 Negative_regulation of Binding of YY1 and DLL1 1 0.00 0 0.79
13 INT98770 Binding of Dll1 and Gt(pU21)50Imeg 1 0.05 0 0.74
14 INT75399 Regulation of Binding of Dll1 and Oprd1 1 0.08 0 0.74
15 INT98771 Binding of Dll1 and Oprm1 1 0.29 0 0.74
16 INT75398 Binding of Dll1 and Oprd1 1 0.11 0 0.74
17 INT148379 UFM1 Positive_regulation of DLL1 1 0.00 1.13 0.63
18 INT52478 Binding of Adarb1 and Ift172 1 0.00 0 0.62
19 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
20 INT86644 Binding of OPRD1 and DLL1 1 0.28 0.17 0.58
21 INT250852 Fgf8 Negative_regulation of Gene_expression of Ecm1 1 0.04 1.1 0.54
22 INT241247 Binding of Pkd2 and Trpv4 1 0.54 1.22 0.52
23 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
24 INT338083 Binding of LEFTY1 and PYCARD 1 0.02 0 0.46
25 INT148377 PDP1 Positive_regulation of NOTCH1 1 0.44 0.64 0.44
26 INT148378 CP Positive_regulation of NOTCH1 1 0.11 0.64 0.44
27 INT99122 Binding of Cacna2d3 and DLL1 1 0.02 0 0.41
28 INT250870 Fgf8 Positive_regulation of Ecm1 1 0.04 0.79 0.38
29 INT340609 Bdnf Regulation of Gene_expression of Wnt3a 1 0.53 0.31 0.36
30 INT297342 Binding of Gnb5 and Smo 1 0.02 1.67 0.34
31 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31
32 INT250856 Fgf8 Positive_regulation of Localization of Mmp3 1 0.11 0.51 0.3
33 INT250864 Fgf8 Positive_regulation of Positive_regulation of Ptger2 1 0.03 0.55 0.28
34 INT126942 Binding of PKD2 and ZACN 1 0.00 1.38 0.28
35 INT250854 Fgf8 Positive_regulation of Positive_regulation of Mmp3 1 0.11 0.55 0.28
36 INT250873 Fgf8 Positive_regulation of GAG 1 0.55 0.48 0.23
37 INT297544 Pou3f3 Regulation of Notch1 1 0.06 0.41 0.2
38 INT115142 TGM7 Positive_regulation of Gene_expression of CITED2 1 0.02 0.45 0.2
39 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
40 INT126944 Binding of PKD2 and Pkd1 2 0.08 2.09 0.19
41 INT149096 PITX2 Positive_regulation of Gene_expression of Egr1 1 0.01 1.23 0.19
42 INT306425 Positive_regulation of Binding of TBX1 and VCF 1 0.02 1.15 0.18
43 INT241250 Binding of Pkd2 and Trpc1 1 0.23 0.3 0.17
44 INT306426 Binding of TBX1 and VCF 1 0.01 1.09 0.17
45 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17
46 INT341818 Binding of PITX2 and Aia1 1 0.00 0.53 0.16
47 INT316052 Notch1 Regulation of Binding of Cd8a 1 0.01 0.86 0.15
48 INT149095 PITX2 Positive_regulation of Casp3 1 0.00 1.51 0.15
49 INT316053 Notch1 Regulation of Binding of Cd4 1 0.02 0.86 0.15
50 INT149092 PITX2 Positive_regulation of RFFL 1 0.00 1.51 0.15
51 INT316050 Binding of Notch1 and Regulation of Binding of Cd8a 1 0.01 0.86 0.15
52 INT316051 Binding of Notch1 and Regulation of Binding of Cd4 1 0.02 0.86 0.15
53 INT136606 Binding of RAN and DLL1 1 0.33 0.45 0.15
54 INT340608 Binding of Creb1 and Wnt3a 1 0.30 0.24 0.14
55 INT250863 Fgf8 Positive_regulation of Ptger2 1 0.03 0.19 0.14
56 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
57 INT250866 Binding of Fgfr4 and Fgf8 1 0.12 0.35 0.11
58 INT241248 Binding of Pkd1 and Pkd2 3 0.22 1.52 0.1
59 INT352751 Pkd2 Regulation of Localization of Vegfa 1 0.11 0.47 0.1
60 INT297546 Neurod1 Regulation of Notch1 1 0.05 0.2 0.1
61 INT352750 Pkd2 Positive_regulation of Vegfa 1 0.20 0.47 0.1
62 INT250860 Fgf8 Regulation of Localization of Ptger2 1 0.02 0.13 0.1
63 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
64 INT250862 Fgf8 Regulation of Localization of Mmp3 1 0.13 0.13 0.1
65 INT250859 Fgf8 Negative_regulation of Gene_expression of Mmp3 1 0.09 0.12 0.09
66 INT250872 Fgf8 Positive_regulation of Mmp3 1 0.11 0.12 0.09
67 INT278217 Binding of Ciita and Notch1 1 0.41 0.22 0.09
68 INT241249 Pkd2 Regulation of Trpc1 1 0.21 0.14 0.09
69 INT286565 Pkd2 Positive_regulation of Positive_regulation of Pkd1 1 0.21 0.11 0.09
70 INT213418 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of VCAM1 1 0.29 0.15 0.08
71 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
72 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
73 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
74 INT213419 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of HGF 1 0.25 0.15 0.08
75 INT241246 Pkd2 Negative_regulation of Gene_expression of Trpv4 1 0.48 0.47 0.07
76 INT297246 Binding of Notch1 and Ncstn 1 0.04 0.32 0.07
77 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
78 INT327871 Binding of Notch1 and Postn 1 0.38 1.42 0.07
79 INT297244 Regulation of Binding of Notch1 and Ncstn 1 0.05 0.32 0.07
80 INT303562 Binding of Fgf10 and Fgfr2 1 0.40 0.88 0.07
81 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
82 INT189557 Binding of NOTCH1 and ROBO4 1 0.01 0.22 0.06
83 INT233278 Binding of LBX1 and Tgif1 1 0.00 0.25 0.06
84 INT250865 Binding of Fgf8 and Fgfr3 1 0.18 0.3 0.05
85 INT250855 Binding of Fgfr2 and Fgf8 1 0.12 0.3 0.05
86 INT262757 SMO Positive_regulation of Regulation of GLI1 1 0.34 0.6 0.04
87 INT349314 Binding of Notch1 and Notch3 1 0.11 0.67 0.04
88 INT270458 Binding of Gli1 and Smo 1 0.00 0.65 0.04
89 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
90 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
91 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
92 INT241253 Gene_expression of Trpv4 Positive_regulation of Gene_expression of Pkd2 1 0.52 0.29 0.03
93 INT347165 Binding of NOTCH1 and PAX5 1 0.05 0.86 0.03
94 INT303563 Binding of Fgf10 and Dysf 1 0.00 0.44 0.03
95 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
96 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
97 INT327876 Postn Regulation of Gene_expression of Notch1 1 0.56 0.92 0.03
98 INT241251 Pkd2 Negative_regulation of Gene_expression of Gopc 1 0.12 0.24 0.03
99 INT347163 NOTCH1 Positive_regulation of MSC 1 0.03 0.85 0.03
100 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
101 INT353288 Smad7 Negative_regulation of Phosphorylation of Tgif1 1 0.08 0.06 0.03
102 INT347164 NOTCH1 Negative_regulation of Gene_expression of EBF1 1 0.03 0.85 0.03
103 INT353283 Prdx2 Positive_regulation of Phosphorylation of Tgif1 1 0.10 0.06 0.03
104 INT353292 Prdx2 Positive_regulation of Tgif1 1 0.10 0.06 0.03
105 INT258529 Binding of JAG1 and NOTCH1 3 0.06 2.44 0
106 INT258528 Binding of NOTCH1 and DLL1 2 0.07 1.6 0
107 INT283346 Binding of Srr and Kif3a 1 0.17 0 0
108 INT339047 Binding of PITX2 and SNRNP70 1 0.00 0.52 0
109 INT291330 Binding of ENO1 and NOTCH1 1 0.03 1.33 0
110 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
111 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
112 INT352148 Ift88 Negative_regulation of Bcl2l2 1 0.00 0.19 0
113 INT193340 Binding of SHOX and LEFTY1 1 0.01 0 0
114 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
115 INT327870 Postn Positive_regulation of Gene_expression of Notch1 1 0.37 0.57 0
116 INT297245 Prnp Positive_regulation of Notch1 1 0.21 0.73 0
117 INT205452 Binding of BMP6 and Acvr2a 1 0.03 0.05 0
118 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
119 INT327873 Postn Regulation of Notch1 1 0.41 0 0
120 INT205975 Binding of PTCH1 and Smo 1 0.02 0.72 0
121 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
122 INT104029 RPGRIP1L Negative_regulation of Gene_expression of LTB 1 0.16 0.06 0
123 INT291329 Binding of NOTCH1 and CERS1 1 0.06 1.42 0
124 INT356083 Binding of App and Notch1 1 0.02 0.2 0
125 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
126 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
127 INT205451 Binding of BMP2 and Acvr2a 1 0.02 0.05 0
128 INT251072 Wnt3a Positive_regulation of Axin2 1 0.23 0.29 0
129 INT227829 CFC1 Positive_regulation of Gene_expression of ERCC6 1 0.03 0 0
130 INT193949 Alph1 Positive_regulation of Notch1 1 0.01 0.08 0
131 INT163092 Notch2 Positive_regulation of Gene_expression of Fos 1 0.08 0.07 0
132 INT339043 SNRNP70 Regulation of PITX2 1 0.00 1.42 0
133 INT273886 Binding of Dll1 and Trip12 1 0.34 0.1 0
134 INT261883 PKD2 Positive_regulation of Localization of Ca2 1 0.02 0.67 0
135 INT222539 Negative_regulation of Binding of Inhba and Acvr2a 1 0.01 0 0
136 INT264736 Hes1 Regulation of Notch2 1 0.20 0.13 0
137 INT205974 Smo Positive_regulation of GLI1 1 0.04 0.66 0
138 INT233279 Binding of TLX1 and Tgif1 1 0.00 0.05 0
139 INT326893 Binding of Tcf4 and Wnt3a 1 0.13 0 0
140 INT352525 SLC25A16 Negative_regulation of SMO 1 0.00 1.1 0
141 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0
142 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
143 INT193950 Alph1 Positive_regulation of Positive_regulation of Notch1 1 0.01 0.07 0
144 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
145 INT250557 Binding of PITX2 and CHDH 1 0.00 2.83 0
146 INT236724 Binding of AXIN1 and Ctnnd2 1 0.39 1.03 0
147 INT222504 Binding of Inhba and Acvr2a 1 0.01 0 0
148 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
149 INT326896 Wnt3a Positive_regulation of Transcription of PLD2 1 0.24 0.06 0
150 INT264727 Binding of Notch1 and Mir199b 1 0.00 0.86 0
151 INT186401 Binding of MKKS and MKS1 1 0.09 0.07 0
152 INT286570 Pkd2 Positive_regulation of Binding of Pkd1 1 0.21 0.73 0
153 INT339044 Binding of PITX2 and SUGT1 1 0.00 2.25 0
154 INT227833 Positive_regulation of CFC1 Positive_regulation of Gene_expression of ERCC6 1 0.03 0 0
155 INT354309 Binding of MYC and PITX2 1 0.01 0.51 0
156 INT251070 Wnt3a Positive_regulation of Cldn3 1 0.30 0.29 0
157 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
158 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
159 INT326894 Wnt3a Positive_regulation of Transcription of Pld1 1 0.24 0.06 0
160 INT295571 Binding of Acvr2b and Mstn 1 0.08 0 0
161 INT264728 Mir199b Regulation of Notch1 1 0.01 0.85 0
162 INT202675 Fgf10 Positive_regulation of Fgfr2 1 0.45 0.07 0
163 INT313840 Binding of Acvr2b and Mstn 1 0.02 0.07 0
164 INT286589 Binding of PKHD1 and Pkd2 1 0.09 0.52 0
165 INT339049 Binding of PITX2 and RENBP 1 0.00 0.27 0
166 INT205965 Binding of Ptch1 and Smo 1 0.03 0.72 0
167 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
168 INT286573 Pkd2 Regulation of Pkd1 1 0.12 0.25 0
169 INT285770 Binding of NOTCH1 and Das 1 0.00 1.14 0
170 INT352150 Ift88 Negative_regulation of Bcl2 1 0.00 0.19 0
171 INT286590 Binding of ID2 and Pkd2 1 0.13 0.13 0
172 INT264726 Binding of Notch1 and Gtf3a 1 0.00 1.68 0
173 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
174 INT356084 Binding of Notch1 and Ncstn 1 0.01 0.07 0
175 INT285769 Das Regulation of NOTCH1 1 0.00 0.78 0
176 INT193947 Notch1 Positive_regulation of Alph1 1 0.01 0.07 0
177 INT270470 Shh Regulation of Gene_expression of VEGFA 1 0.39 0.15 0
178 INT291333 Binding of CSHL1 and NOTCH1 1 0.05 1.16 0
179 INT299456 Binding of Gabpa and Notch1 1 0.21 0.09 0
180 INT264725 Binding of Hes1 and Notch1 1 0.03 0.84 0
181 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
182 INT274705 Binding of TXNRD1 and Dh 1 0.00 0 0
183 INT270469 Shh Positive_regulation of VEGFA 1 0.29 0.12 0
184 INT352149 Ift88 Negative_regulation of Bcl2l1 1 0.00 0.19 0
185 INT258564 Binding of NOTCH1 and Crlf2 1 0.27 0.67 0
186 INT270468 Shh Positive_regulation of Gene_expression of VEGFA 1 0.44 0.08 0
187 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0
188 INT273887 Binding of Jag1 and Notch2 1 0.02 1.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for determination of left/right symmetry. They are ordered first by their pain relevance and then by number of times they were reported in determination of left/right symmetry. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT50056 Positive_regulation of Dll1 13 0.67 3.16 13.7
2 INT56883 Positive_regulation of Dll1 8 0.49 3.49 12.25
3 INT340600 Gene_expression of Wnt3a 1 0.68 2.14 9.14
4 INT56884 Gene_expression of Dll1 9 0.48 1.15 8.98
5 INT56019 Gene_expression of Dll1 11 0.78 3.38 8.71
6 INT65803 Gene_expression of Dh 10 0.32 1.24 8.07
7 INT55859 Binding of Dll1 6 0.35 0 7.64
8 INT58607 Negative_regulation of Dll1 9 0.43 1.89 7.06
9 INT70287 Positive_regulation of Gene_expression of Dll1 6 0.70 3.58 6.55
10 INT250832 Gene_expression of Fgf8 1 0.77 13.36 6.2
11 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65
12 INT54002 Negative_regulation of Dh 6 0.20 3.05 5.06
13 INT71406 Regulation of Dll1 3 0.35 0.79 4.44
14 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41
15 INT10542 Gene_expression of DLL1 16 0.71 3.7 4.21
16 INT40036 Binding of DLL1 10 0.36 2.88 3.95
17 INT72179 Negative_regulation of Dll1 5 0.33 4.09 3.84
18 INT340603 Regulation of Gene_expression of Wnt3a 1 0.54 0.49 3.75
19 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7
20 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54
21 INT49190 Regulation of Dll1 3 0.44 0.26 3.24
22 INT340595 Positive_regulation of Gene_expression of Wnt3a 1 0.61 0.86 3.11
23 INT55148 Binding of Dll1 5 0.48 0.66 2.97
24 INT108793 Gene_expression of PITX2 12 0.75 3.91 2.89
25 INT132773 Negative_regulation of Acvr2b 3 0.41 1.55 2.87
26 INT139872 Regulation of Notch1 14 0.45 7.69 2.82
27 INT66891 Negative_regulation of Positive_regulation of Dll1 1 0.41 0 2.72
28 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64
29 INT67329 Positive_regulation of Positive_regulation of Dll1 2 0.32 0 2.56
30 INT132315 Positive_regulation of DLL1 6 0.67 3.4 2.45
31 INT50057 Regulation of Notch1 3 0.39 0.87 2.14
32 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
33 INT140036 Positive_regulation of Gene_expression of Notch1 6 0.61 2 1.86
34 INT52633 Negative_regulation of Notch1 4 0.42 2.99 1.84
35 INT104912 Gene_expression of Acvr2a 8 0.63 4.48 1.81
36 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
37 INT159099 Negative_regulation of Positive_regulation of Dll1 1 0.25 0.74 1.76
38 INT159100 Regulation of Positive_regulation of Dll1 1 0.26 0.7 1.73
39 INT250841 Positive_regulation of Gene_expression of Fgf8 1 0.69 3.8 1.72
40 INT159098 Negative_regulation of Gene_expression of Dll1 1 0.18 0.62 1.65
41 INT52757 Localization of Dll1 1 0.20 0 1.6
42 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57
43 INT163381 Transcription of Notch1 2 0.69 0.41 1.52
44 INT105296 Regulation of DLL1 3 0.11 0.77 1.43
45 INT340596 Negative_regulation of Gene_expression of Wnt3a 1 0.51 0.38 1.4
46 INT130098 Negative_regulation of NOTCH1 11 0.42 5.45 1.33
47 INT250850 Negative_regulation of Gene_expression of Fgf8 1 0.42 2.79 1.33
48 INT110784 Protein_catabolism of Notch1 8 0.21 2.32 1.31
49 INT149295 Regulation of NOTCH1 10 0.13 4.26 1.22
50 INT133371 Negative_regulation of Binding of Dll1 1 0.41 0.5 1.22
51 INT183068 Gene_expression of SMO 2 0.17 0.27 1.2
52 INT110780 Localization of Notch1 2 0.06 0.47 1.19
53 INT100154 Regulation of PITX2 5 0.60 0.48 1.15
54 INT35095 Negative_regulation of Notch2 3 0.36 0.06 1.15
55 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14
56 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
57 INT123727 Negative_regulation of Notch1 6 0.21 1.22 1.11
58 INT250840 Negative_regulation of Fgf8 1 0.43 1.92 1.11
59 INT97695 Positive_regulation of Dh 3 0.33 1.44 1.1
60 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
61 INT277461 Positive_regulation of Gene_expression of Fgf8 1 0.24 0.47 1.05
62 INT99121 Transcription of DLL1 1 0.14 0 1.02
63 INT142813 Localization of RPGRIP1L 1 0.59 0.99 1.01
64 INT108795 Transcription of PITX2 1 0.69 0.46 0.96
65 INT340604 Regulation of Wnt3a 1 0.24 0 0.95
66 INT6833 Binding of Notch1 4 0.36 0.05 0.94
67 INT138980 Binding of PITX2 15 0.47 10.34 0.88
68 INT316382 Gene_expression of LEFTY1 9 0.09 0.47 0.82
69 INT258932 Positive_regulation of TBX1 3 0.39 2.73 0.82
70 INT270447 Binding of Smo 2 0.07 2.61 0.78
71 INT99120 Positive_regulation of Transcription of DLL1 1 0.10 0 0.77
72 INT114604 Positive_regulation of Acvr2a 2 0.41 0 0.73
73 INT57510 Regulation of Notch2 1 0.05 0 0.73
74 INT105947 Binding of Dh 3 0.35 0.79 0.72
75 INT139089 Negative_regulation of Gene_expression of Dll1 2 0.43 0 0.69
76 INT140037 Positive_regulation of Positive_regulation of Notch1 2 0.22 1.34 0.69
77 INT137850 Gene_expression of PKD2 9 0.65 6.68 0.63
78 INT205957 Negative_regulation of Smo 4 0.08 2.57 0.6
79 INT6831 Negative_regulation of Binding of Notch1 1 0.27 0 0.6
80 INT136920 Positive_regulation of Gene_expression of NOTCH1 12 0.49 8.25 0.59
81 INT296583 Gene_expression of Fgf10 3 0.59 2.64 0.57
82 INT296594 Regulation of Fgf10 1 0.15 1.53 0.56
83 INT110782 Negative_regulation of Localization of Notch1 1 0.03 0.33 0.56
84 INT241235 Binding of Pkd2 11 0.48 2.43 0.55
85 INT149294 Regulation of Localization of NOTCH1 1 0.10 0.9 0.55
86 INT110785 Positive_regulation of Protein_catabolism of Notch1 1 0.05 0.33 0.55
87 INT79888 Gene_expression of Notch2 3 0.43 0.39 0.54
88 INT241243 Gene_expression of Pkd2 30 0.77 9.05 0.53
89 INT149297 Protein_catabolism of NOTCH1 2 0.15 0.87 0.51
90 INT125381 Regulation of Dh 3 0.29 1.07 0.49
91 INT250845 Protein_catabolism of Fgf8 1 0.98 1.64 0.48
92 INT268007 Gene_expression of Fgf8 8 0.72 1.38 0.47
93 INT206484 Localization of Shh 2 0.75 1.14 0.46
94 INT316383 Binding of LEFTY1 1 0.05 0.36 0.46
95 INT340598 Binding of Wnt3a 1 0.33 0.15 0.46
96 INT210125 Regulation of Axin1 1 0.02 2.45 0.46
97 INT158426 Binding of NOTCH1 10 0.36 7.95 0.45
98 INT218293 Gene_expression of Acvr2b 14 0.76 4.22 0.44
99 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
100 INT159221 Negative_regulation of TBX1 4 0.41 4.22 0.43
101 INT277465 Regulation of Gene_expression of Fgf8 2 0.25 0.43 0.43
102 INT65606 Binding of TBX1 2 0.30 3.13 0.41
103 INT35096 Negative_regulation of Negative_regulation of Notch2 1 0.36 0 0.4
104 INT340606 Positive_regulation of Wnt3a 1 0.61 0.49 0.4
105 INT241236 Negative_regulation of Pkd2 11 0.43 1.82 0.39
106 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
107 INT346261 Gene_expression of MKKS 1 0.40 0.66 0.34
108 INT250826 Transcription of Fgf8 1 0.71 0.71 0.34
109 INT346249 Phosphorylation of MKKS 1 0.43 0.61 0.31
110 INT10543 Negative_regulation of DLL1 3 0.14 0.67 0.3
111 INT258685 Regulation of Gene_expression of Notch1 2 0.40 1.45 0.3
112 INT356400 Transcription of Smo 1 0.02 0.05 0.3
113 INT277474 Positive_regulation of Gene_expression of SMO 1 0.11 0 0.29
114 INT51514 Positive_regulation of Wnt3a 3 0.04 3.32 0.28
115 INT269082 Gene_expression of TBX1 1 0.14 0.36 0.28
116 INT216120 Negative_regulation of SMO 2 0.49 3.05 0.27
117 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
118 INT166727 Regulation of Gene_expression of PITX2 1 0.60 0.09 0.26
119 INT241238 Positive_regulation of Pkd2 5 0.46 1.44 0.24
120 INT250836 Binding of Fgf8 3 0.35 0.66 0.24
121 INT241244 Localization of Pkd2 1 0.74 0.35 0.24
122 INT306427 Localization of TBX1 1 0.20 1.08 0.23
123 INT316049 Regulation of Regulation of Notch1 1 0.03 0.92 0.23
124 INT306428 Positive_regulation of Localization of TBX1 1 0.14 1.08 0.23
125 INT140639 Gene_expression of FOXF1 3 0.52 0.89 0.22
126 INT130099 Negative_regulation of Positive_regulation of NOTCH1 4 0.43 2.56 0.21
127 INT193360 Localization of LEFTY1 3 0.04 0.49 0.21
128 INT250833 Localization of Fgf8 1 0.74 0.46 0.21
129 INT250842 Negative_regulation of Binding of Fgf8 1 0.43 0.33 0.21
130 INT297241 Positive_regulation of Positive_regulation of Notch1 2 0.40 1.02 0.2
131 INT338088 Positive_regulation of LEFTY1 1 0.03 0 0.2
132 INT115160 Gene_expression of CITED2 1 0.04 0.45 0.2
133 INT115153 Positive_regulation of Gene_expression of CITED2 1 0.02 0.45 0.2
134 INT193945 Binding of Notch1 7 0.15 1.28 0.19
135 INT149094 Positive_regulation of Gene_expression of PITX2 1 0.05 1.23 0.19
136 INT130096 Positive_regulation of Positive_regulation of NOTCH1 2 0.50 1.15 0.18
137 INT210123 Localization of Axin1 1 0.04 0.84 0.17
138 INT66933 Binding of AXIN1 6 0.32 1.8 0.16
139 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
140 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
141 INT136609 Positive_regulation of Binding of DLL1 1 0.49 0.45 0.15
142 INT250835 Positive_regulation of Fgf8 1 0.50 0.42 0.14
143 INT354535 Regulation of Negative_regulation of Pkd2 1 0.15 1.03 0.14
144 INT263410 Negative_regulation of Axin1 1 0.01 0 0.14
145 INT249096 Regulation of FOXF1 1 0.19 0.28 0.14
146 INT136922 Positive_regulation of Gene_expression of DLL1 2 0.46 1.28 0.13
147 INT297239 Positive_regulation of Gene_expression of Notch1 2 0.40 1.31 0.13
148 INT253190 Localization of Shh 2 0.77 1.06 0.13
149 INT353269 Negative_regulation of Positive_regulation of Tgif1 1 0.11 0.5 0.13
150 INT51512 Negative_regulation of Positive_regulation of Wnt3a 1 0.04 1.3 0.13
151 INT136919 Negative_regulation of Gene_expression of DLL1 1 0.54 0.3 0.13
152 INT51513 Positive_regulation of Positive_regulation of Wnt3a 1 0.04 1.31 0.13
153 INT353275 Positive_regulation of Tgif1 1 0.13 0.5 0.13
154 INT338718 Positive_regulation of Localization of NOTCH1 1 0.04 0.6 0.13
155 INT222585 Transcription of Acvr2a 1 0.16 0 0.13
156 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
157 INT316042 Negative_regulation of Gene_expression of Notch1 1 0.27 1.7 0.12
158 INT162568 Regulation of TBX1 3 0.35 1.54 0.11
159 INT258933 Protein_catabolism of TBX1 1 0.43 0.75 0.11
160 INT213448 Localization of FOXF1 1 0.58 0.15 0.1
161 INT270442 Transcription of Shh 1 0.53 0.25 0.09
162 INT213515 Binding of Shh 8 0.37 1.92 0.08
163 INT294014 Regulation of AXIN1 3 0.24 1.04 0.08
164 INT214463 Binding of Wnt3a 2 0.26 0.23 0.08
165 INT145364 Negative_regulation of AXIN1 2 0.33 0.52 0.08
166 INT141999 Regulation of Gene_expression of NOTCH1 2 0.04 0.97 0.08
167 INT270453 Regulation of Shh 1 0.27 0.83 0.08
168 INT213440 Negative_regulation of FOXF1 1 0.33 0.14 0.08
169 INT327728 Regulation of Gene_expression of Notch1 2 0.27 0.73 0.07
170 INT256862 Regulation of Shh 1 0.25 0 0.07
171 INT345344 Regulation of SMO 1 0.23 1.07 0.06
172 INT286583 Localization of PKD2 1 0.35 0.17 0.06
173 INT262962 Localization of PITX2 1 0.42 0.64 0.06
174 INT261879 Binding of PKD2 3 0.13 2.59 0.05
175 INT193845 Localization of Notch1 2 0.78 0.32 0.05
176 INT183818 Positive_regulation of MKKS 1 0.01 1.82 0.05
177 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
178 INT193850 Regulation of Localization of Notch1 1 0.14 0.33 0.05
179 INT352129 Negative_regulation of Ift88 1 0.00 0.72 0.05
180 INT244699 Positive_regulation of AXIN1 1 0.02 0 0.05
181 INT262772 Binding of SMO 1 0.27 0.59 0.05
182 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
183 INT262777 Localization of SMO 1 0.59 0.6 0.04
184 INT298336 Phosphorylation of Notch1 1 0.02 0.13 0.04
185 INT356474 Negative_regulation of PITX2 1 0.03 0.07 0.04
186 INT241241 Positive_regulation of Gene_expression of Pkd2 3 0.50 1.3 0.03
187 INT222608 Negative_regulation of Gene_expression of Acvr2a 3 0.10 0.29 0.03
188 INT260760 Positive_regulation of Fgf10 2 0.53 0.43 0.03
189 INT350959 Transcription of NOTCH1 2 0.05 0.84 0.03
190 INT289614 Positive_regulation of CITED2 1 0.37 0.41 0.03
191 INT353260 Gene_expression of Tgif1 1 0.21 0 0.03
192 INT303535 Positive_regulation of Gene_expression of Fgf10 1 0.53 0.34 0.03
193 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
194 INT283314 Localization of Kif3a 1 0.69 0 0.03
195 INT353277 Positive_regulation of Gene_expression of Tgif1 1 0.18 0 0.03
196 INT253181 Transcription of Shh 1 0.68 0.54 0.03
197 INT353279 Phosphorylation of Tgif1 1 0.22 0.06 0.03
198 INT199811 Gene_expression of CFC1 3 0.11 0.27 0
199 INT232397 Protein_catabolism of Notch1 3 0.64 1.56 0
200 INT241239 Regulation of Pkd2 2 0.27 0.55 0
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