GO:0007398

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Name ectoderm development
Categary Process
Go Slim No
Go Link GO:0007398
Unique Molecular Interactions 93
Total Molecular Interactions 118
Total Single Events 825
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ectoderm development. They are ordered first by their pain relevance and then by number of times they were reported for ectoderm development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT108129 GDNF Regulation of Gene_expression of GRHL3 1 0.21 0.39 1.71
2 INT95791 Binding of SSTR1 and GRHL3 1 0.38 0.57 0.99
3 INT108128 GDNF Regulation of Localization of GRHL3 1 0.24 0.18 0.83
4 INT140922 Btnl2 Negative_regulation of EDA 1 0.00 0.88 0.8
5 INT343838 EDA Positive_regulation of TLR4 1 0.11 0.87 0.51
6 INT92743 Binding of NF2 and LMOD1 1 0.00 0.08 0.46
7 INT92744 Binding of ADRB2 and NF2 1 0.00 0.1 0.41
8 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
9 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
10 INT343832 Positive_regulation of EDA Positive_regulation of TLR4 1 0.11 0.43 0.27
11 INT343864 EDA Positive_regulation of Gene_expression of TLR4 1 0.11 0.44 0.25
12 INT234992 Car2 Positive_regulation of Jup 1 0.02 0.27 0.2
13 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
14 INT201762 JUP Regulation of Gene_expression of Ccnd1 1 0.03 0.8 0.13
15 INT201791 JUP Regulation of Gene_expression of Myc 1 0.49 0.8 0.13
16 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
17 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
18 INT146181 Kdm6a Negative_regulation of Gene_expression of KRT6A 1 0.03 0.31 0.11
19 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
20 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
21 INT339111 Binding of ERBB2 and JUP 1 0.38 0.62 0.07
22 INT339108 Binding of ESR1 and JUP 1 0.38 0.62 0.07
23 INT349914 Binding of Cdh1 and Jup 1 0.11 0.47 0.07
24 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
25 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
26 INT234968 IgG Negative_regulation of Jup 1 0.02 1.09 0.06
27 INT281224 Binding of Calm3 and Zbtb17 1 0.00 0.11 0.06
28 INT225230 Ad Positive_regulation of Nf2 1 0.04 1.37 0.04
29 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
30 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
31 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
32 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
33 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
34 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
35 INT192044 Binding of DSP and Jup 2 0.24 2.39 0
36 INT234995 Binding of CDH16 and Jup 1 0.00 0.27 0
37 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
38 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
39 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
40 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
41 INT220818 Binding of Ctnnb1 and Myc 1 0.06 0.13 0
42 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
43 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0
44 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
45 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0
46 INT234969 Jup Regulation of Gene_expression of Dsp 1 0.01 0.54 0
47 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
48 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
49 INT136693 Gtf3a Positive_regulation of Ctnnb1 1 0.05 0 0
50 INT235007 Binding of DSG1 and Jup 1 0.08 0.36 0
51 INT235005 Positive_regulation of Binding of DSG1 and Jup 1 0.08 0.36 0
52 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
53 INT234983 IgG Positive_regulation of Protein_catabolism of Jup 1 0.03 0.61 0
54 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
55 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
56 INT192045 Jup Positive_regulation of RYR2 1 0.11 0.29 0
57 INT234970 Binding of Jup and Lat 1 0.01 0 0
58 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
59 INT266555 Mapk8 Regulation of JUP 1 0.08 0.1 0
60 INT220821 Binding of MAX and Ctnnb1 1 0.09 0.13 0
61 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
62 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
63 INT234987 Binding of Jup and Dsp 1 0.01 0.18 0
64 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0
65 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0
66 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
67 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
68 INT352689 VAX2 Positive_regulation of HIST1H1B 1 0.01 0.59 0
69 INT270470 Shh Regulation of Gene_expression of VEGFA 1 0.39 0.15 0
70 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
71 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
72 INT192042 Binding of Jup and Ryr2 1 0.17 1.09 0
73 INT234982 Binding of Jup and Pkp1 1 0.00 0 0
74 INT270469 Shh Positive_regulation of VEGFA 1 0.29 0.12 0
75 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0
76 INT270468 Shh Positive_regulation of Gene_expression of VEGFA 1 0.44 0.08 0
77 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ectoderm development. They are ordered first by their pain relevance and then by number of times they were reported in ectoderm development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95794 Gene_expression of GRHL3 9 0.68 5.57 9.9
2 INT127961 Transcription of GRHL3 1 0.45 4.34 8.17
3 INT127964 Regulation of Transcription of GRHL3 1 0.28 2.54 4.84
4 INT56404 Gene_expression of EDA 16 0.75 7.09 4.24
5 INT127962 Positive_regulation of GRHL3 3 0.32 2.67 3.69
6 INT127963 Positive_regulation of Gene_expression of GRHL3 1 0.44 1.85 3.4
7 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
8 INT74241 Positive_regulation of Gene_expression of EDA 3 0.49 4.93 2.24
9 INT108131 Localization of GRHL3 3 0.73 1.03 2.18
10 INT93764 Binding of GRHL3 3 0.36 1.79 2.07
11 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
12 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
13 INT24850 Regulation of GRHL3 4 0.45 0.32 1.9
14 INT4188 Binding of NF2 7 0.46 3.52 1.79
15 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
16 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
17 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
18 INT49402 Positive_regulation of EDA 6 0.61 4.23 1.43
19 INT198840 Transcription of EDA 1 0.58 0.97 1.26
20 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
21 INT54044 Negative_regulation of EDA 7 0.42 2.54 1.14
22 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
23 INT93765 Negative_regulation of Binding of GRHL3 1 0.41 0.43 1.14
24 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
25 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
26 INT242171 Protein_catabolism of JUP 4 0.96 0.91 1.01
27 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
28 INT225221 Negative_regulation of Nf2 1 0.57 18.06 0.83
29 INT102262 Localization of NF2 1 0.14 0.6 0.79
30 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
31 INT202848 Gene_expression of Nf2 5 0.59 4.93 0.63
32 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
33 INT146179 Gene_expression of KRT6A 23 0.75 9.39 0.52
34 INT266535 Phosphorylation of JUP 3 0.79 0.63 0.49
35 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
36 INT242168 Transcription of JUP 4 0.67 1.17 0.46
37 INT206484 Localization of Shh 2 0.75 1.14 0.46
38 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
39 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
40 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
41 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
42 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
43 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
44 INT242169 Positive_regulation of Protein_catabolism of JUP 1 0.49 0.23 0.34
45 INT158794 Binding of EDA 2 0.47 1.61 0.33
46 INT185886 Gene_expression of JUP 20 0.75 15.41 0.32
47 INT274626 Positive_regulation of Positive_regulation of GRHL3 1 0.22 0.67 0.32
48 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
49 INT225219 Positive_regulation of Gene_expression of Nf2 1 0.43 1.27 0.27
50 INT221860 Negative_regulation of Jup 9 0.15 6.82 0.26
51 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
52 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
53 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
54 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
55 INT234903 Gene_expression of Jup 1 0.23 7.1 0.2
56 INT352698 Gene_expression of VAX2 1 0.06 0.85 0.19
57 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17
58 INT151721 Negative_regulation of Localization of Ctnnb1 1 0.23 0.96 0.17
59 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17
60 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
61 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
62 INT146180 Positive_regulation of Gene_expression of KRT6A 2 0.49 1.43 0.16
63 INT202855 Regulation of Nf2 2 0.05 0.79 0.15
64 INT129118 Negative_regulation of NF2 2 0.56 1.89 0.15
65 INT205083 Positive_regulation of JUP 6 0.49 5.51 0.13
66 INT253190 Localization of Shh 2 0.77 1.06 0.13
67 INT130374 Transcription of Ctnnb1 1 0.19 0 0.13
68 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
69 INT225224 Positive_regulation of Nf2 1 0.59 3.4 0.12
70 INT49401 Regulation of EDA 1 0.23 0.07 0.11
71 INT49403 Positive_regulation of Regulation of EDA 1 0.40 0.07 0.11
72 INT225222 Negative_regulation of Negative_regulation of Nf2 1 0.41 1.55 0.11
73 INT242173 Positive_regulation of Gene_expression of JUP 2 0.49 2.37 0.09
74 INT270442 Transcription of Shh 1 0.53 0.25 0.09
75 INT213515 Binding of Shh 8 0.37 1.92 0.08
76 INT309877 Localization of JUP 2 0.73 1.38 0.08
77 INT339206 Negative_regulation of Localization of JUP 1 0.41 1.1 0.08
78 INT270453 Regulation of Shh 1 0.27 0.83 0.08
79 INT234894 Negative_regulation of Protein_catabolism of Jup 1 0.17 2.87 0.08
80 INT205973 Binding of SHH 3 0.35 1.03 0.07
81 INT256862 Regulation of Shh 1 0.25 0 0.07
82 INT234866 Regulation of Jup 2 0.08 0.58 0.06
83 INT53489 Regulation of NF2 2 0.44 1.34 0.06
84 INT281218 Binding of Zbtb17 1 0.01 0.11 0.06
85 INT234899 Positive_regulation of Protein_catabolism of Jup 1 0.21 0.88 0.06
86 INT329585 Regulation of Negative_regulation of Jup 1 0.01 0.23 0.06
87 INT234931 Protein_catabolism of Jup 1 0.29 2.23 0.06
88 INT234915 Positive_regulation of Gene_expression of Jup 1 0.15 2.7 0.06
89 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
90 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
91 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
92 INT225217 Positive_regulation of Positive_regulation of Nf2 1 0.43 1.07 0.04
93 INT225218 Positive_regulation of Negative_regulation of Nf2 1 0.40 1.07 0.04
94 INT225227 Gene_expression of NF2 4 0.65 4.49 0.03
95 INT234890 Phosphorylation of Jup 1 0.24 1.56 0.03
96 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
97 INT234867 Localization of Jup 1 0.24 2.84 0.03
98 INT253181 Transcription of Shh 1 0.68 0.54 0.03
99 INT266537 Positive_regulation of Phosphorylation of JUP 2 0.49 0.29 0
100 INT76959 Binding of Ctnnb1 2 0.34 0.69 0
101 INT266534 Negative_regulation of Phosphorylation of JUP 2 0.41 0.15 0
102 INT242174 Negative_regulation of Gene_expression of JUP 2 0.41 2.58 0
103 INT221864 Binding of JUP 2 0.36 1.05 0
104 INT221859 Binding of Jup 2 0.14 2.21 0
105 INT162479 Negative_regulation of Gene_expression of KRT6A 1 0.57 0 0
106 INT309874 Positive_regulation of Binding of JUP 1 0.49 0.32 0
107 INT230651 Phosphorylation of Ctnnb1 1 0.10 0 0
108 INT230674 Positive_regulation of Phosphorylation of Ctnnb1 1 0.06 0 0
109 INT158793 Negative_regulation of Positive_regulation of EDA 1 0.38 0 0
110 INT326137 Protein_catabolism of Ctnnb1 1 0.02 1.08 0
111 INT162475 Regulation of Gene_expression of KRT6A 1 0.60 0 0
112 INT232990 Localization of KRT6A 1 0.43 0.37 0
113 INT355576 Negative_regulation of Negative_regulation of Ctnnb1 1 0.02 1.14 0
114 INT234877 Positive_regulation of Binding of Jup 1 0.21 0.24 0
115 INT242170 Negative_regulation of JUP 1 0.42 0.85 0
116 INT232997 Positive_regulation of KRT6A 1 0.40 0.82 0
117 INT232985 Positive_regulation of Localization of KRT6A 1 0.29 0.37 0
118 INT220769 Positive_regulation of Positive_regulation of Ctnnb1 1 0.10 0 0
119 INT290918 Negative_regulation of Positive_regulation of Shh 1 0.41 0.25 0
120 INT158795 Negative_regulation of Gene_expression of EDA 1 0.37 0 0
121 INT322618 Binding of KRT6A 1 0.36 0.56 0
122 INT256367 Localization of EDA 1 0.13 0 0
123 INT289452 Positive_regulation of NF2 1 0.01 0.08 0
124 INT309876 Regulation of JUP 1 0.60 0.67 0
125 INT230972 Positive_regulation of Gene_expression of SHH 1 0.18 0.07 0
126 INT234918 Positive_regulation of Jup 1 0.15 1.08 0
127 INT352696 Positive_regulation of VAX2 1 0.05 0.06 0
128 INT162477 Negative_regulation of KRT6A 1 0.41 0.17 0
129 INT290929 Binding of Shh 1 0.31 0.1 0
130 INT309875 Regulation of Gene_expression of JUP 1 0.44 0.39 0
131 INT290927 Regulation of Positive_regulation of Shh 1 0.23 0 0
132 INT234896 Negative_regulation of Gene_expression of Jup 1 0.13 0.54 0
133 INT355092 Positive_regulation of Transcription of JUP 1 0.49 0.05 0
134 INT270449 Negative_regulation of Positive_regulation of Shh 1 0.43 0.24 0
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