GO:0007417

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Name central nervous system development
Categary Process
Go Slim No
Go Link GO:0007417
Unique Molecular Interactions 775
Total Molecular Interactions 1050
Total Single Events 7697
Pain Genes Associated 79

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for central nervous system development. They are ordered first by their pain relevance and then by number of times they were reported for central nervous system development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT73539 Binding of Ngf and Ngfr 5 0.45 3.99 4
3 INT289979 Binding of Helt and Negative_regulation of Maoa 1 0.00 0.17 3.14
4 INT255318 Binding of Dpep1 and Nrcam 1 0.00 0 2.16
5 INT356313 Crh Positive_regulation of Localization of Helt 1 0.02 0 2.11
6 INT334345 Binding of GRP and Helt 1 0.02 0 1.79
7 INT142073 Binding of Helt and Nrm 1 0.00 0 1.74
8 INT108129 GDNF Regulation of Gene_expression of GRHL3 1 0.21 0.39 1.71
9 INT130839 Gfap Positive_regulation of S100B 1 0.51 1.9 1.56
10 INT222335 Binding of Bdnf and Ngfr 3 0.05 2.66 1.48
11 INT298283 Pou4f1 Positive_regulation of Gene_expression of Runx1 1 0.50 1.4 1.48
12 INT158711 Cdk5 Positive_regulation of Phosphorylation of Trh 1 0.02 0 1.46
13 INT6976 Helt Regulation of Gene_expression of St8sia1 1 0.00 0.07 1.45
14 INT356326 Crhr1 Regulation of Gene_expression of Helt 1 0.01 0.65 1.32
15 INT280480 Binding of Bdnf and Ngfr 5 0.25 3.14 1.27
16 INT256041 Binding of Ngfr and Ntrk1 3 0.14 0.9 1.13
17 INT346986 Binding of SHC3 and PAG1 1 0.35 1.02 1.12
18 INT212280 Vsnl1 Negative_regulation of Ltp 1 0.00 0.72 1.11
19 INT298272 Runx1 Positive_regulation of Gene_expression of Ntrk3 1 0.52 0.88 1.09
20 INT212281 Vsnl1 Regulation of Ltp 1 0.00 1.32 1.07
21 INT82024 Binding of Ngfr and Ngf 2 0.33 1.48 1.05
22 INT76001 Ngf Positive_regulation of Ngfr 1 0.16 0.93 1.05
23 INT221 Chd7 Negative_regulation of Th 1 0.02 0 1.04
24 INT242642 Binding of BDNF and Ngfr 2 0.21 1.38 1.01
25 INT265070 Reln Positive_regulation of Gene_expression of Fos 1 0.02 0.51 1.01
26 INT298298 Calca Negative_regulation of Gene_expression of Runx1 1 0.19 0.33 1
27 INT298274 Gene_expression of Runx1 Negative_regulation of Calca 1 0.19 0.33 1
28 INT95791 Binding of SSTR1 and GRHL3 1 0.38 0.57 0.99
29 INT127672 Binding of NGFR and NTRK1 1 0.17 2.28 0.97
30 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
31 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
32 INT6975 Zeb1 Positive_regulation of St8sia1 1 0.03 0.17 0.91
33 INT333303 Zic2 Regulation of Gene_expression of Slc6a4 1 0.60 0.47 0.91
34 INT255377 Nrcam Regulation of Positive_regulation of AIS 1 0.00 0 0.9
35 INT74872 Igh-Dex Positive_regulation of Chd7 1 0.01 0.5 0.89
36 INT326455 Runx1 Positive_regulation of Gene_expression of Trpv1 1 0.45 0 0.88
37 INT49085 Negative_regulation of MBP Positive_regulation of Eae1 1 0.00 1.51 0.87
38 INT298289 Runx1 Negative_regulation of Ntrk2 1 0.60 1.09 0.87
39 INT298295 Runx1 Negative_regulation of Gene_expression of Ntrk1 2 0.38 0.45 0.86
40 INT49084 MBP Positive_regulation of Eae1 1 0.00 1.49 0.86
41 INT128945 Binding of MBP and Mog 1 0.01 1.59 0.86
42 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
43 INT73538 Ngf Positive_regulation of Ngfr 2 0.41 1.05 0.85
44 INT196578 Ephb1 Positive_regulation of Phosphorylation of Mapk9 1 0.13 0.5 0.85
45 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
46 INT196576 Trib3 Positive_regulation of Phosphorylation of Mapk9 1 0.02 0.5 0.85
47 INT108128 GDNF Regulation of Localization of GRHL3 1 0.24 0.18 0.83
48 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
49 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
50 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82
51 INT322266 Binding of LIG4 and NOS3 1 0.02 2.35 0.82
52 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
53 INT274785 S100B Positive_regulation of Ngf 1 0.05 0.61 0.8
54 INT69692 Helt Regulation of Prkaca 1 0.00 0.33 0.76
55 INT117412 RYBP Negative_regulation of LIG4 1 0.00 0.42 0.76
56 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
57 INT213726 Binding of Ngfr and Ntrk1 1 0.14 0.96 0.72
58 INT334348 GRP Regulation of Helt 1 0.01 0 0.72
59 INT289333 Binding of Ngfr and Rtn4r 1 0.03 2.35 0.72
60 INT289332 Binding of Ngfr and Lingo1 1 0.04 2.36 0.72
61 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
62 INT326457 Runx1 Regulation of Mrgpra3 1 0.37 0.1 0.71
63 INT326456 Runx1 Regulation of Pip4k2b 1 0.09 0.11 0.71
64 INT274786 Ngf Positive_regulation of Gene_expression of S100B 1 0.05 0.63 0.71
65 INT82021 Negative_regulation of Binding of Ngfr and Ngf 1 0.29 0.32 0.69
66 INT197233 Positive_regulation of Rora Positive_regulation of Localization of Helt 1 0.00 0 0.68
67 INT68561 Binding of Gli3 and Ust 1 0.01 0.68 0.68
68 INT125543 Arsa Negative_regulation of Phosphorylation of Nfkbia 1 0.00 0.52 0.68
69 INT152923 Aanat Positive_regulation of Helt 1 0.00 0.42 0.67
70 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
71 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
72 INT333305 Zic2 Positive_regulation of Transcription of Slc6a4 1 0.68 0 0.66
73 INT48304 Positive_regulation of MBP Positive_regulation of PLP1 1 0.10 0.97 0.64
74 INT48303 MBP Positive_regulation of PLP1 1 0.10 0.97 0.64
75 INT255994 Binding of Ang and Il1rn 1 0.09 1.21 0.63
76 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
77 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
78 INT280895 Runx1 Positive_regulation of Gene_expression of Ret 2 0.33 0.2 0.58
79 INT125546 Arsa Negative_regulation of Gene_expression of PTGS2 1 0.00 0.53 0.58
80 INT333302 Zic2 Positive_regulation of Slc6a4 1 0.68 0.11 0.57
81 INT134532 Grin2a Regulation of Ngfr 1 0.02 0 0.57
82 INT134528 Grin1 Regulation of Ngfr 1 0.03 0 0.57
83 INT134531 Gria1 Regulation of Ngfr 1 0.01 0 0.57
84 INT290594 BDNF Positive_regulation of Localization of S100B 1 0.08 0.6 0.57
85 INT139429 LPA Positive_regulation of Negative_regulation of MBP 1 0.00 0.78 0.56
86 INT212282 Vsnl1 Negative_regulation of Positive_regulation of Ltp 1 0.00 0.36 0.56
87 INT298278 Runx1 Negative_regulation of Gene_expression of Ntrk2 1 0.44 0.8 0.56
88 INT334346 GRP Regulation of Gene_expression of Helt 1 0.03 0 0.55
89 INT202043 MMP13 Regulation of Protein_catabolism of COL2A1 1 0.01 0.54 0.54
90 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54
91 INT255999 Binding of Ang and H7 1 0.00 0.38 0.54
92 INT76002 Ngf Positive_regulation of Ngfr 1 0.05 0.48 0.53
93 INT245558 Runx3 Regulation of Ngfr 1 0.06 1 0.53
94 INT245553 Runx1 Positive_regulation of Gene_expression of Ntrk1 2 0.45 1.41 0.52
95 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
96 INT163481 Binding of Bdnf and Positive_regulation of Regulation of Helt 1 0.21 0 0.51
97 INT163480 Bdnf Positive_regulation of Regulation of Helt 1 0.22 0 0.51
98 INT135755 Pomc Positive_regulation of Positive_regulation of Id3 1 0.17 0 0.5
99 INT135752 Pomc Positive_regulation of Id3 1 0.16 0 0.5
100 INT127677 NGF Regulation of Gene_expression of NGFR 1 0.20 1.11 0.5
101 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49
102 INT161227 Binding of Ngfr and Tnf 1 0.06 0.41 0.49
103 INT327806 Binding of ADORA1 and ADORA2A 1 0.06 0.18 0.49
104 INT249000 Helt Negative_regulation of Per2 1 0.01 0 0.48
105 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
106 INT13247 Binding of Arc and Helt 1 0.00 0.37 0.45
107 INT120295 Ngf Positive_regulation of Positive_regulation of Ngfr 1 0.47 0.22 0.43
108 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
109 INT326458 Runx1 Negative_regulation of Gene_expression of Calca 1 0.18 0.05 0.43
110 INT298287 Runx1 Negative_regulation of Gene_expression of Ntrk3 1 0.32 0.4 0.43
111 INT96615 Binding of F11 and Nrcam 1 0.12 0.52 0.43
112 INT160046 INPPL1 Regulation of Gene_expression of PTEN 1 0.41 0.6 0.42
113 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
114 INT160049 PTEN Regulation of Gene_expression of INPPL1 1 0.41 0.6 0.42
115 INT231303 Binding of Prnp and Helt 1 0.02 3.23 0.41
116 INT298286 Runx3 Regulation of Gene_expression of Runx1 1 0.47 0.36 0.41
117 INT72345 MBP Positive_regulation of Localization of PRSS1 1 0.00 0.22 0.41
118 INT205926 Helt Regulation of Cpox 1 0.01 0 0.41
119 INT106114 Binding of ASIC2 and Pick1 1 0.14 0.1 0.4
120 INT298270 Gene_expression of Runx1 Positive_regulation of Ntrk3 1 0.35 0.34 0.4
121 INT298261 Pou4f1 Negative_regulation of Gene_expression of Runx1 1 0.45 0.58 0.4
122 INT223829 Binding of GSTM1 and GSTP1 2 0.41 2.78 0.39
123 INT106115 Pick1 Positive_regulation of Phosphorylation of ASIC2 1 0.13 0.07 0.39
124 INT312122 ELANE Positive_regulation of Protein_catabolism of COL2A1 1 0.05 0.65 0.39
125 INT278944 ZEB1 Negative_regulation of IL1B 1 0.00 1.09 0.39
126 INT298296 Gene_expression of Runx1 Negative_regulation of Gene_expression of Ntrk2 1 0.44 0.33 0.39
127 INT298266 Gene_expression of Runx1 Positive_regulation of Ntrk1 1 0.28 0.34 0.39
128 INT106117 Pick1 Positive_regulation of ASIC2 1 0.14 0.09 0.39
129 INT58969 TNF Regulation of Regulation of RPS6KA6 1 0.35 0.34 0.38
130 INT73537 Ntf3 Positive_regulation of Ngfr 1 0.21 0.1 0.38
131 INT278960 ZEB1 Negative_regulation of MMP3 1 0.00 1.05 0.38
132 INT278943 ZEB1 Negative_regulation of Gene_expression of MMP3 1 0.00 1.05 0.38
133 INT58967 TNF Regulation of RPS6KA6 1 0.18 0.33 0.38
134 INT129769 Binding of LYZ and S100B 1 0.33 0.86 0.37
135 INT73536 Ngf Regulation of Ngfr 1 0.22 0.08 0.37
136 INT249004 Helt Regulation of Clock 1 0.01 0.09 0.37
137 INT151545 Adcy1 Positive_regulation of Regulation of Fmr1 1 0.48 0.37 0.37
138 INT249015 Regulation of Helt Regulation of Clock 1 0.01 0.09 0.37
139 INT151544 Camk4 Positive_regulation of Regulation of Fmr1 1 0.50 0.36 0.37
140 INT112619 Mapk9 Regulation of Il1b 1 0.16 1.11 0.36
141 INT112620 Mapk9 Regulation of Tnf 1 0.16 1.11 0.36
142 INT122757 Helt Positive_regulation of Trib3 1 0.00 0.2 0.35
143 INT257741 HRAS Negative_regulation of PTEN 1 0.15 1.06 0.35
144 INT122758 Positive_regulation of Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
145 INT122755 Helt Positive_regulation of Pik3cb 1 0.00 0.19 0.35
146 INT122756 Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
147 INT257737 Positive_regulation of HRAS Negative_regulation of PTEN 1 0.17 1.07 0.35
148 INT150458 Prss12 Regulation of Helt 1 0.00 0 0.34
149 INT112283 Bdnf Regulation of Gene_expression of Ngfr 1 0.14 0.28 0.34
150 INT297342 Binding of Gnb5 and Smo 1 0.02 1.67 0.34
151 INT163482 Bdnf Regulation of Negative_regulation of Helt 1 0.01 0 0.34
152 INT285565 Positive_regulation of Zeb1 Negative_regulation of IL2 1 0.02 0.62 0.33
153 INT155064 Stat3 Negative_regulation of Tp53bp2 1 0.06 3.69 0.33
154 INT285563 Zeb1 Negative_regulation of IL2 1 0.01 0.62 0.33
155 INT163483 Bdnf Regulation of Regulation of Helt 1 0.01 0 0.33
156 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
157 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
158 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
159 INT40219 Ang Negative_regulation of REN 1 0.00 0 0.3
160 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
161 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
162 INT264523 PTGDS Positive_regulation of Gene_expression of COL2A1 1 0.03 1.24 0.3
163 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
164 INT298282 Pou4f1 Regulation of Gene_expression of Runx1 1 0.48 0.36 0.29
165 INT245563 Negative_regulation of Runx1 Regulation of Ret 1 0.39 0.76 0.29
166 INT220194 PTGER2 Negative_regulation of COL2A1 1 0.26 0.55 0.29
167 INT245556 Runx1 Regulation of Ret 1 0.56 0.76 0.29
168 INT166952 LYRM4 Positive_regulation of Gene_expression of TP53 1 0.05 0.75 0.28
169 INT146911 Binding of Helt and Nts 1 0.00 0 0.28
170 INT212289 Vsnl1 Negative_regulation of Grin2a 1 0.04 0.38 0.28
171 INT214615 FOXC1 Positive_regulation of Gene_expression of Ang 1 0.01 0.29 0.28
172 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
173 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
174 INT130108 DLL3 Negative_regulation of Positive_regulation of MAPK1 1 0.13 0 0.28
175 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28
176 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
177 INT256001 Ang Negative_regulation of Il1rn 1 0.11 0.25 0.27
178 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
179 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
180 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
181 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
182 INT239570 Binding of PDGFC and AIS 1 0.04 0.9 0.26
183 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
184 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
185 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26
186 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
187 INT245557 Runx1 Positive_regulation of Gene_expression of Tbx15 1 0.02 0.75 0.25
188 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
189 INT245561 Gene_expression of Runx1 Positive_regulation of Gene_expression of Tbx15 1 0.02 0.8 0.25
190 INT156879 Gene_expression of TP53 Negative_regulation of Positive_regulation of PDF 1 0.45 0.9 0.24
191 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
192 INT89469 Fk Positive_regulation of Gene_expression of Lhcgr 1 0.01 0 0.24
193 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24
194 INT316375 Ang Positive_regulation of Nfkb1 1 0.08 0.73 0.23
195 INT105915 Helt Regulation of Gnrh1 1 0.02 0 0.23
196 INT229177 IFRD1 Regulation of TP53 1 0.13 0.68 0.23
197 INT245555 Runx1 Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
198 INT89470 CGA Regulation of Gene_expression of Lhcgr 1 0.00 0 0.23
199 INT245565 Runx1 Negative_regulation of Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
200 INT89468 Fk Regulation of Gene_expression of Lhcgr 1 0.01 0 0.23

Single Events

The table below shows the top 100 pain related interactions that have been reported for central nervous system development. They are ordered first by their pain relevance and then by number of times they were reported in central nervous system development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT133211 Gene_expression of Runx1 169 0.77 83.4 76.16
2 INT60388 Gene_expression of Helt 90 0.07 19.18 41.72
3 INT11796 Positive_regulation of Helt 52 0.31 11.7 29.22
4 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
5 INT55908 Gene_expression of Ngfr 74 0.78 34.46 28.8
6 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4
7 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58
8 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8
9 INT13244 Binding of Helt 30 0.31 4.56 18.01
10 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
11 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
12 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
13 INT11795 Negative_regulation of Helt 33 0.28 6.51 14.76
14 INT13572 Localization of Helt 31 0.36 5.85 13.41
15 INT109223 Negative_regulation of Cdk5 14 0.59 3.27 12.73
16 INT245517 Positive_regulation of Gene_expression of Runx1 49 0.69 17.7 12.38
17 INT541 Positive_regulation of MBP 31 0.67 28.56 12.24
18 INT133212 Negative_regulation of Runx1 21 0.58 11.16 11.89
19 INT66038 Positive_regulation of Ngfr 32 0.69 26.07 11.75
20 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54
21 INT133210 Positive_regulation of Runx1 33 0.69 18.25 10.12
22 INT245538 Negative_regulation of Gene_expression of Runx1 20 0.58 11.68 9.97
23 INT95794 Gene_expression of GRHL3 9 0.68 5.57 9.9
24 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
25 INT17741 Gene_expression of MBP 67 0.78 23.67 9.65
26 INT130731 Protein_catabolism of COL2A1 47 0.96 21.86 9.28
27 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17
28 INT101602 Positive_regulation of Cdk5 15 0.70 4.1 8.96
29 INT38173 Gene_expression of Ang 40 0.75 32.63 8.86
30 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57
31 INT33944 Regulation of Helt 13 0.24 2.86 8.49
32 INT75921 Negative_regulation of Ngfr 13 0.59 8.58 8.35
33 INT157580 Phosphorylation of Cdk5 4 0.77 0.73 8.33
34 INT127961 Transcription of GRHL3 1 0.45 4.34 8.17
35 INT48310 Binding of Ngfr 25 0.48 9.72 8.16
36 INT39301 Gene_expression of Chd7 50 0.26 27.06 8.13
37 INT11568 Gene_expression of ADORA2A 14 0.73 1.51 7.79
38 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
39 INT61542 Positive_regulation of Ngfr 15 0.70 6.35 7.34
40 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
41 INT14637 Negative_regulation of MBP 19 0.43 7.06 7.18
42 INT78713 Negative_regulation of Ngfr 9 0.54 7.07 6.73
43 INT169596 Transcription of Runx1 12 0.71 5.55 6.27
44 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
45 INT245515 Regulation of Runx1 14 0.61 5.07 6.22
46 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
47 INT109124 Positive_regulation of TIMP3 8 0.61 5.57 5.72
48 INT101604 Regulation of Cdk5 10 0.61 2.2 5.53
49 INT81326 Positive_regulation of Gene_expression of Ang 17 0.67 18.5 5.46
50 INT60585 Regulation of TP53 59 0.59 54.55 5.21
51 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
52 INT142435 Gene_expression of NES 86 0.78 47.53 4.92
53 INT245536 Regulation of Gene_expression of Runx1 11 0.58 6.22 4.88
54 INT127964 Regulation of Transcription of GRHL3 1 0.28 2.54 4.84
55 INT20552 Negative_regulation of Gene_expression of COL2A1 29 0.56 11.92 4.81
56 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
57 INT17742 Localization of S100B 44 0.80 17.14 4.65
58 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
59 INT96492 Gene_expression of NGFR 24 0.00 12.3 4.59
60 INT37912 Negative_regulation of Chd7 10 0.26 5.84 4.46
61 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
62 INT64711 Regulation of Ngfr 10 0.45 3.12 4.33
63 INT28734 Gene_expression of Reln 7 0.74 5.76 4.33
64 INT55743 Gene_expression of Timp2 25 0.31 8.95 4.3
65 INT217742 Positive_regulation of Gene_expression of COL2A1 20 0.67 9.76 4.23
66 INT121170 Positive_regulation of Gene_expression of Ngfr 10 0.64 9.32 3.94
67 INT189629 Negative_regulation of TIMP3 14 0.48 7.63 3.91
68 INT121171 Negative_regulation of Gene_expression of Ngfr 6 0.58 3.46 3.89
69 INT276198 Positive_regulation of Pten 1 0.52 5.02 3.88
70 INT55907 Binding of Ngfr 13 0.47 5.79 3.75
71 INT93200 Gene_expression of ASIC2 6 0.60 3.27 3.7
72 INT127962 Positive_regulation of GRHL3 3 0.32 2.67 3.69
73 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
74 INT104480 Phosphorylation of Mapk9 8 0.80 6.59 3.62
75 INT536 Binding of MBP 17 0.48 6.52 3.56
76 INT151171 Positive_regulation of Pten 20 0.55 13.3 3.54
77 INT255367 Phosphorylation of Nrcam 1 0.07 0 3.48
78 INT53021 Positive_regulation of COL2A1 29 0.55 27.75 3.47
79 INT12385 Localization of NGFR 6 0.81 3.05 3.47
80 INT61540 Negative_regulation of Gene_expression of Ngfr 11 0.59 6.36 3.43
81 INT127963 Positive_regulation of Gene_expression of GRHL3 1 0.44 1.85 3.4
82 INT208291 Negative_regulation of Pten 2 0.44 5.42 3.36
83 INT130729 Negative_regulation of Protein_catabolism of COL2A1 15 0.42 7.59 3.35
84 INT192676 Binding of PTEN 14 0.46 10.58 3.06
85 INT87314 Gene_expression of Htt 112 0.78 55.82 3.03
86 INT8103 Binding of TP53 46 0.44 40.2 2.96
87 INT37734 Positive_regulation of Ang 18 0.46 9.17 2.87
88 INT131929 Positive_regulation of Gene_expression of S100B 25 0.67 12.61 2.83
89 INT212394 Gene_expression of Zic2 44 0.78 2.88 2.82
90 INT184477 Negative_regulation of Pten 27 0.59 15.61 2.8
91 INT93197 Positive_regulation of ASIC2 7 0.61 1.94 2.79
92 INT61541 Positive_regulation of Gene_expression of Ngfr 7 0.53 2.87 2.75
93 INT119383 Gene_expression of Pten 11 0.59 10.33 2.73
94 INT20551 Negative_regulation of COL2A1 31 0.55 21.98 2.66
95 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
96 INT138789 Gene_expression of Cdk5 6 0.76 5.19 2.62
97 INT96693 Binding of COL2A1 45 0.46 37.11 2.61
98 INT23775 Regulation of S100B 24 0.62 16.75 2.57
99 INT77213 Transcription of ADORA2A 1 0.69 0 2.55
100 INT77852 Binding of Chd7 8 0.31 4.1 2.51
101 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
102 INT119838 Positive_regulation of PTEN 25 0.67 21.71 2.5
103 INT167096 Positive_regulation of Gene_expression of Helt 10 0.05 0.89 2.49
104 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48
105 INT75225 Transcription of Ngfr 4 0.60 1.95 2.44
106 INT55952 Transcription of TP53 16 0.61 12.14 2.36
107 INT92791 Negative_regulation of Szt2 1 0.03 2.4 2.33
108 INT3151 Localization of MBP 27 0.80 7.58 2.28
109 INT121910 Binding of Nrcam 4 0.03 1.51 2.26
110 INT14488 Regulation of MBP 5 0.25 5.17 2.25
111 INT120109 Negative_regulation of Timp2 8 0.33 3.28 2.23
112 INT67737 Negative_regulation of Pam 6 0.51 4.08 2.19
113 INT179885 Regulation of PTEN 8 0.26 11.88 2.18
114 INT108131 Localization of GRHL3 3 0.73 1.03 2.18
115 INT117415 Negative_regulation of LIG4 4 0.04 1.59 2.17
116 INT157579 Binding of Cdk5 3 0.35 0.47 2.13
117 INT37733 Negative_regulation of Ang 11 0.41 3.23 2.09
118 INT224615 Negative_regulation of Gene_expression of Pten 7 0.59 2.99 2.09
119 INT276201 Phosphorylation of Pten 1 0.61 1.31 2.08
120 INT151538 Positive_regulation of Fmr1 21 0.68 12.24 2.07
121 INT93764 Binding of GRHL3 3 0.36 1.79 2.07
122 INT169597 Negative_regulation of Transcription of Runx1 3 0.58 1.92 2.07
123 INT205920 Regulation of Gene_expression of Helt 4 0.02 1 2.06
124 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02
125 INT130112 Gene_expression of DLL3 1 0.25 0 2
126 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
127 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
128 INT80798 Positive_regulation of Chd7 16 0.14 7.95 1.95
129 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
130 INT64712 Localization of Ngfr 4 0.78 1.19 1.91
131 INT245529 Binding of Runx1 9 0.48 4.42 1.9
132 INT24850 Regulation of GRHL3 4 0.45 0.32 1.9
133 INT65855 Localization of TP53 18 0.76 17.08 1.89
134 INT96588 Gene_expression of MOG 18 0.75 11.41 1.89
135 INT158710 Negative_regulation of Binding of Cdk5 1 0.40 0 1.84
136 INT265064 Binding of Reln 1 0.02 2.7 1.83
137 INT104478 Positive_regulation of Mapk9 5 0.67 5.56 1.81
138 INT89618 Positive_regulation of Map1b 1 0.68 2.48 1.81
139 INT135077 Binding of GSTP1 11 0.48 7.03 1.8
140 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
141 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
142 INT58563 Negative_regulation of S100B 13 0.51 11.75 1.77
143 INT129019 Gene_expression of Ndn 31 0.75 11.09 1.73
144 INT145884 Negative_regulation of SH3GL3 19 0.43 12.67 1.72
145 INT265066 Positive_regulation of Reln 1 0.02 1.59 1.72
146 INT194242 Positive_regulation of Gene_expression of MBP 9 0.45 4.1 1.71
147 INT28735 Localization of Reln 2 0.12 1.49 1.7
148 INT104479 Negative_regulation of Mapk9 3 0.37 2.83 1.69
149 INT151543 Binding of Fmr1 56 0.48 19.4 1.65
150 INT305526 Negative_regulation of Positive_regulation of Runx1 1 0.42 2.7 1.65
151 INT276171 Positive_regulation of Gene_expression of Pten 3 0.52 7.24 1.64
152 INT89467 Gene_expression of Lhcgr 9 0.36 1.59 1.62
153 INT140247 Negative_regulation of Negative_regulation of Ngfr 3 0.33 3.15 1.59
154 INT167894 Negative_regulation of PTS 3 0.14 3.96 1.54
155 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
156 INT151169 Positive_regulation of Gene_expression of Pten 15 0.45 12.88 1.53
157 INT163594 Regulation of Ngfr 5 0.43 2.55 1.53
158 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
159 INT140245 Binding of Gli3 3 0.36 2.65 1.46
160 INT228249 Binding of Pten 7 0.48 3.26 1.45
161 INT127679 Positive_regulation of Gene_expression of NGFR 7 0.67 4.98 1.43
162 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
163 INT302990 Protein_catabolism of MBP 5 0.88 3.75 1.42
164 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
165 INT281470 Regulation of Gene_expression of Pten 4 0.39 1.13 1.42
166 INT172953 Binding of Trp53 33 0.37 20.76 1.41
167 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
168 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
169 INT276196 Positive_regulation of Phosphorylation of Pten 1 0.38 0.19 1.41
170 INT159312 Regulation of Reln 4 0.43 1.79 1.4
171 INT304045 Transcription of PTEN 2 0.51 4.12 1.4
172 INT112655 Negative_regulation of PAM 3 0.57 0.97 1.39
173 INT109222 Positive_regulation of Negative_regulation of Cdk5 2 0.50 0.23 1.39
174 INT220070 Negative_regulation of ASIC2 1 0.02 1.09 1.39
175 INT158709 Negative_regulation of Phosphorylation of Cdk5 1 0.40 0 1.39
176 INT145221 Binding of Tp53 10 0.37 8.59 1.37
177 INT210060 Localization of SH3GL3 4 0.59 6.61 1.37
178 INT276181 Negative_regulation of Gene_expression of Pten 1 0.44 2.48 1.37
179 INT64713 Regulation of Gene_expression of Ngfr 4 0.50 2.04 1.36
180 INT51064 Regulation of Gene_expression of S100B 13 0.60 5.02 1.34
181 INT151540 Regulation of Fmr1 8 0.59 6.08 1.34
182 INT90226 Gene_expression of Mapk9 3 0.65 1.94 1.34
183 INT138939 Positive_regulation of Transcription of Ngfr 3 0.43 0.89 1.31
184 INT117232 Localization of COL2A1 11 0.72 7.34 1.3
185 INT239575 Regulation of PDGFC 1 0.07 4.93 1.3
186 INT345377 Positive_regulation of Positive_regulation of TIMP3 1 0.37 0.09 1.29
187 INT137811 Negative_regulation of NGFR 4 0.50 2.22 1.28
188 INT56127 Positive_regulation of NGFR 8 0.49 5.3 1.27
189 INT13573 Negative_regulation of Localization of Helt 3 0.00 0.86 1.26
190 INT45175 Gene_expression of PTS 5 0.56 1.46 1.24
191 INT216380 Gene_expression of PAX6 49 0.78 15.63 1.22
192 INT171057 Gene_expression of PDGFC 7 0.15 5.84 1.22
193 INT164372 Positive_regulation of Positive_regulation of Ngfr 6 0.62 4.1 1.22
194 INT12386 Binding of NGFR 6 0.48 2.15 1.22
195 INT232359 Gene_expression of UGT8 1 0.08 0.18 1.22
196 INT123839 Positive_regulation of Timp2 6 0.15 4.69 1.21
197 INT190014 Regulation of Pten 8 0.62 6.03 1.2
198 INT151542 Positive_regulation of Positive_regulation of Fmr1 4 0.58 2.17 1.2
199 INT119832 Positive_regulation of Gene_expression of PTEN 12 0.49 7.12 1.19
200 INT110392 Transcription of Ngfr 3 0.52 2.48 1.19
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