GO:0007418

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Name ventral midline development
Categary Process
Go Slim No
Go Link GO:0007418
Unique Molecular Interactions 35
Total Molecular Interactions 42
Total Single Events 171
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ventral midline development. They are ordered first by their pain relevance and then by number of times they were reported for ventral midline development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT104831 Binding of GLI2 and NFKB1 1 0.08 0 0.8
2 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
3 INT116936 Positive_regulation of GLI2 Positive_regulation of JUN 1 0.12 0.07 0.41
4 INT104834 Binding of GLI2 and IGKV2OR2-1 1 0.00 0 0.22
5 INT149900 Gli1 Regulation of Localization of Mmp14 1 0.02 1.17 0.22
6 INT303937 Positive_regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
7 INT303940 Regulation of Binding of GLI2 and CCL5 1 0.01 0 0.18
8 INT303938 Binding of GLI2 and CCL5 1 0.01 0 0.18
9 INT303939 TRAP Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
10 INT303941 CCL2 Positive_regulation of Protein_catabolism of GLI2 1 0.01 0 0.16
11 INT104837 IGKV2OR2-1 Negative_regulation of GLI2 1 0.00 0 0.15
12 INT24321 Pomc Positive_regulation of Localization of Gli1 1 0.07 0 0.1
13 INT165159 Gli1 Regulation of Penk 1 0.24 0.07 0.09
14 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
15 INT165157 Gli1 Regulation of Igfbp5 1 0.24 0.07 0.09
16 INT270457 Binding of Ptch1 and Gli1 1 0.02 1.3 0.08
17 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05
18 INT343538 TGFB1 Positive_regulation of Gene_expression of GLI2 1 0.08 0.2 0.05
19 INT270458 Binding of Gli1 and Smo 1 0.00 0.65 0.04
20 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
21 INT343545 Binding of GLI2 and ROCK1 1 0.07 0.65 0.03
22 INT343544 Negative_regulation of GLI2 Negative_regulation of Gene_expression of PTHLH 1 0.24 0.53 0.03
23 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
24 INT333294 Binding of Zic2 and Gli1 1 0.03 0 0
25 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
26 INT289372 Negative_regulation of Gli1 Positive_regulation of cac 1 0.48 0.68 0
27 INT207374 Gene_expression of GLI2 Negative_regulation of Gene_expression of Chol1 1 0.04 0 0
28 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
29 INT343548 GLI2 Positive_regulation of Gene_expression of PTHLH 1 0.28 0.94 0
30 INT333293 Binding of Zic1 and Gli1 1 0.01 0 0
31 INT343549 GLI2 Positive_regulation of GYPA 1 0.05 0.95 0
32 INT289373 Gli1 Positive_regulation of cac 1 0.52 0.68 0
33 INT207336 Gene_expression of GLI2 Negative_regulation of Gene_expression of CYP27A1 1 0.00 0 0
34 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
35 INT343539 GLI2 Regulation of PTHLH 1 0.15 0.25 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ventral midline development. They are ordered first by their pain relevance and then by number of times they were reported in ventral midline development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99
2 INT90926 Positive_regulation of GLI2 12 0.45 4.99 1.74
3 INT104839 Negative_regulation of GLI2 8 0.35 2.7 1.24
4 INT119674 Localization of GLI2 6 0.52 2.84 0.99
5 INT182322 Negative_regulation of Gene_expression of GLI2 6 0.11 2.37 0.98
6 INT64173 Regulation of Gene_expression of GLI2 4 0.37 2.89 0.88
7 INT289474 Regulation of GLI2 2 0.06 1.08 0.87
8 INT104840 Binding of GLI2 6 0.08 1.89 0.72
9 INT126376 Gene_expression of Gli1 8 0.68 4.52 0.7
10 INT24317 Gene_expression of Gli1 4 0.54 1.46 0.47
11 INT149890 Positive_regulation of Gene_expression of Gli1 1 0.48 1.56 0.41
12 INT119675 Positive_regulation of Localization of GLI2 1 0.32 0.43 0.3
13 INT24320 Localization of Gli1 6 0.77 0.63 0.29
14 INT234407 Positive_regulation of Binding of GLI2 2 0.05 1.33 0.28
15 INT165153 Positive_regulation of Gli1 4 0.59 1.17 0.25
16 INT303943 Protein_catabolism of GLI2 2 0.11 0 0.22
17 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
18 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
19 INT24316 Regulation of Localization of Gli1 1 0.51 0 0.19
20 INT182321 Positive_regulation of Gene_expression of GLI2 2 0.28 1.32 0.16
21 INT149891 Negative_regulation of Gene_expression of Gli1 1 0.41 0.68 0.14
22 INT24318 Regulation of Gene_expression of Gli1 1 0.23 0 0.09
23 INT352606 Localization of Gli1 1 0.38 1.19 0.08
24 INT205973 Binding of SHH 3 0.35 1.03 0.07
25 INT165151 Negative_regulation of Positive_regulation of Gli1 1 0.50 0.09 0.07
26 INT290112 Positive_regulation of Gene_expression of Gli1 1 0.50 1.09 0.05
27 INT290114 Negative_regulation of Gene_expression of Gli1 1 0.31 1.09 0.05
28 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
29 INT352603 Negative_regulation of Localization of Gli1 1 0.18 0.6 0.04
30 INT270456 Positive_regulation of Gli1 1 0.02 0.62 0.04
31 INT352604 Regulation of Gli1 1 0.21 0.6 0.04
32 INT246011 Transcription of Gli1 2 0.29 0 0
33 INT207371 Positive_regulation of Transcription of GLI2 1 0.03 0.08 0
34 INT24319 Positive_regulation of Localization of Gli1 1 0.66 0 0
35 INT230972 Positive_regulation of Gene_expression of SHH 1 0.18 0.07 0
36 INT307407 Regulation of Localization of GLI2 1 0.01 0.67 0
37 INT207369 Transcription of GLI2 1 0.05 0.08 0
38 INT289370 Binding of Gli1 1 0.37 2.78 0
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