GO:0007492

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Name endoderm development
Categary Process
Go Slim No
Go Link GO:0007492
Unique Molecular Interactions 508
Total Molecular Interactions 674
Total Single Events 4446
Pain Genes Associated 35

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for endoderm development. They are ordered first by their pain relevance and then by number of times they were reported for endoderm development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
2 INT302646 ARSA Positive_regulation of TGFB1 1 0.10 0.52 1.76
3 INT129717 TGFB1 Positive_regulation of Gene_expression of TNFRSF10D 3 0.38 4.29 1.71
4 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
5 INT147108 TGFB1 Positive_regulation of Gene_expression of FN1 4 0.47 1.01 1.63
6 INT130786 Positive_regulation of Oprm1 Positive_regulation of Arc 1 0.27 0.9 1.31
7 INT89878 Pdyn Positive_regulation of Gene_expression of Nkx2-5 1 0.35 0 1.29
8 INT75483 Binding of SGCG and TGFB1 1 0.52 2.27 1.19
9 INT142077 TGFB1 Negative_regulation of Binding of IDO1 1 0.15 2.07 1.19
10 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
11 INT263048 Tgfb1 Positive_regulation of Gene_expression of Mmp2 1 0.13 0.81 1.07
12 INT129206 RYBP Positive_regulation of Gene_expression of TGFB1 1 0.00 1.04 0.95
13 INT101259 Gata6 Negative_regulation of Gene_expression of ALOX15 1 0.42 0.67 0.89
14 INT326663 Bdnf Regulation of Positive_regulation of Arc 1 0.16 1.46 0.88
15 INT149559 Tgfb1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0 0.88
16 INT149562 Tgfb1 Positive_regulation of CXCL10 1 0.00 0 0.88
17 INT149564 Tgfb1 Positive_regulation of Gene_expression of CXCL10 1 0.00 0 0.88
18 INT149560 Tgfb1 Positive_regulation of Ccr5 1 0.00 0 0.88
19 INT101258 Gene_expression of Gata6 Negative_regulation of Positive_regulation of ALOX15 1 0.42 0.65 0.87
20 INT326664 Bdnf Positive_regulation of Arc 1 0.27 1.07 0.86
21 INT326661 Bdnf Positive_regulation of Gene_expression of Arc 1 0.27 1.96 0.86
22 INT222985 CP Positive_regulation of Positive_regulation of TGFB1 1 0.00 1.57 0.85
23 INT149561 Tgfb1 Positive_regulation of Gene_expression of CCL2 1 0.00 0 0.83
24 INT149563 Tgfb1 Positive_regulation of CCL2 1 0.00 0 0.83
25 INT149558 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.00 0 0.82
26 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 0.00 0 0.82
27 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 0.47 1.21 0.77
28 INT161483 Slc7a12 Regulation of Gene_expression of TGFB1 1 0.14 1.21 0.77
29 INT161482 Il1b Negative_regulation of TGFB1 1 0.45 1.17 0.76
30 INT178581 CNTN2 Positive_regulation of PTHLH 1 0.24 2.16 0.75
31 INT161484 Binding of TGFB1 and Il1b 1 0.37 1.16 0.73
32 INT302642 Binding of ARSA and TGFB1 1 0.05 0.28 0.68
33 INT132696 Binding of Arc and Pag1 1 0.00 0.5 0.67
34 INT354913 VDR Positive_regulation of TGFB1 1 0.05 1.33 0.67
35 INT89877 Pdyn Positive_regulation of Nkx2-5 1 0.11 0 0.64
36 INT137017 Tgfb1 Positive_regulation of Gene_expression of Acta2 1 0.00 0.84 0.61
37 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
38 INT335995 Il10 Negative_regulation of Tgfb1 1 0.06 0.83 0.57
39 INT56088 TGFB1 Positive_regulation of Transcription of SERPINE1 1 0.46 0.83 0.57
40 INT302645 ARSA Positive_regulation of Gene_expression of TGFB1 1 0.08 0.28 0.55
41 INT129270 Binding of Wnt4 and Efs 1 0.00 0 0.55
42 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
43 INT240808 Arc Regulation of Ins1 1 0.09 1.41 0.54
44 INT89144 TGFB1 Regulation of Gene_expression of Tcstv1 1 0.00 0.53 0.53
45 INT92918 Atp6v0a2 Negative_regulation of Gene_expression of Tgfb1 1 0.01 0.83 0.52
46 INT138151 Tgfb1 Regulation of IL1B 1 0.01 0.29 0.49
47 INT89145 TGFB1 Positive_regulation of Tcstv1 1 0.00 0.49 0.49
48 INT138153 Tgfb1 Regulation of IL6 1 0.01 0.29 0.49
49 INT302643 ARSA Positive_regulation of Localization of TGFB1 1 0.08 0.12 0.49
50 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
51 INT138146 Tgfb1 Regulation of Mmp3 1 0.00 0.23 0.46
52 INT117888 Gfap Regulation of Arc 1 0.05 0.37 0.46
53 INT138149 Tgfb1 Regulation of Mmp2 1 0.00 0.23 0.46
54 INT117887 Glul Regulation of Arc 1 0.02 0.37 0.46
55 INT164415 Tgfb1 Regulation of Crlf1 1 0.01 0.78 0.45
56 INT13247 Binding of Arc and Helt 1 0.00 0.37 0.45
57 INT148377 PDP1 Positive_regulation of NOTCH1 1 0.44 0.64 0.44
58 INT148378 CP Positive_regulation of NOTCH1 1 0.11 0.64 0.44
59 INT354206 Arc Positive_regulation of Accn2 1 0.02 0.57 0.42
60 INT354208 Arc Positive_regulation of Accn3 1 0.08 0.97 0.42
61 INT75488 Binding of TGFB1 and Tgfbr1 1 0.23 0.78 0.41
62 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41
63 INT222180 Binding of HNF1B and TFAM 1 0.01 1.48 0.4
64 INT92690 Tgfb1 Positive_regulation of Transcription of Fgf2 1 0.32 1.8 0.4
65 INT165567 Tnf Regulation of Gene_expression of Tgfb1 1 0.41 1.15 0.39
66 INT13077 Tac2 Positive_regulation of NKX2-1 1 0.00 0 0.39
67 INT336340 Glp2r Positive_regulation of Gene_expression of TGFB1 1 0.14 0.67 0.39
68 INT94853 TGFB1 Positive_regulation of Gene_expression of COL7A1 3 0.06 0.57 0.38
69 INT300608 Arc Regulation of Dnm2 1 0.15 0.27 0.37
70 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34
71 INT137018 Tgfb1 Positive_regulation of Pscs 1 0.01 0.43 0.34
72 INT224700 TNF Positive_regulation of Angpt1 1 0.00 0.63 0.34
73 INT137013 Tgfb1 Positive_regulation of Gene_expression of Pscs 1 0.01 0.43 0.34
74 INT225119 Foxm1 Regulation of Localization of TGFB1 1 0.01 0.63 0.34
75 INT333457 Binding of PPARA and TGFB1 1 0.04 0 0.34
76 INT56089 TGFB1 Regulation of SERPINE1 1 0.41 0.41 0.33
77 INT299549 Binding of TGFB1 and Egf 1 0.02 0.32 0.32
78 INT146893 TNF Negative_regulation of Dkk1 1 0.01 1.27 0.3
79 INT102849 Tgfb1 Positive_regulation of Gene_expression of Col3a1 1 0.04 0.85 0.3
80 INT200640 Agtr2 Positive_regulation of Gene_expression of TGFB1 1 0.03 1.35 0.29
81 INT150351 Binding of EXT1 and MMP12 1 0.04 3.68 0.29
82 INT200639 Ace Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
83 INT137023 Gene_expression of SMAD2 Negative_regulation of Gene_expression of Acta2 1 0.00 0.43 0.29
84 INT200631 AGT Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
85 INT300552 Napa Positive_regulation of Gene_expression of TGFB1 1 0.01 0.88 0.29
86 INT137033 Tgfb1 Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28
87 INT225101 TGFB1 Positive_regulation of Localization of COL1A1 1 0.03 0.59 0.28
88 INT225100 TGFB1 Positive_regulation of Gene_expression of COL1A1 1 0.04 0.59 0.28
89 INT240807 Arc Regulation of Gene_expression of Lepr 1 0.05 0.72 0.28
90 INT178578 Binding of PTHLH and CALCRL 1 0.01 0.68 0.27
91 INT231035 Arc Regulation of Gene_expression of Fos 1 0.17 0.31 0.27
92 INT137032 Il6 Positive_regulation of Localization of Tgfb1 1 0.04 0.51 0.27
93 INT233782 Binding of PTHLH and SCT 1 0.06 0 0.27
94 INT83395 Binding of IL1RN and Tgfb1 1 0.01 0.17 0.26
95 INT342164 Binding of Csf2 and Nkx2-1 1 0.01 0.52 0.26
96 INT139094 Csf2 Regulation of Tgfb1 1 0.42 0.58 0.26
97 INT271450 Thy1 Regulation of TGFB1 1 0.00 0.62 0.25
98 INT222981 TGFB1 Positive_regulation of Gene_expression of MMRN1 1 0.09 1.62 0.25
99 INT225098 ZNF630 Regulation of Localization of TGFB1 1 0.01 0.44 0.24
100 INT225105 ZNF630 Regulation of TGFB1 1 0.01 0.44 0.24
101 INT9720 Binding of TGFB1 and Egf 1 0.01 0 0.23
102 INT168710 Ifng Regulation of TGFB1 1 0.00 0.3 0.23
103 INT112596 Tgfb1 Negative_regulation of Negative_regulation of Mptp1 1 0.26 0.72 0.22
104 INT112595 Tgfb1 Negative_regulation of Gene_expression of Mptp1 1 0.27 0.72 0.22
105 INT89475 TGFB1 Positive_regulation of Gene_expression of PTHLH 3 0.61 3.64 0.21
106 INT354217 Arc Positive_regulation of Accn1 1 0.01 0.29 0.21
107 INT346458 ROS1 Regulation of Localization of TGFB1 1 0.00 1.71 0.21
108 INT114905 TGFB1 Positive_regulation of Transcription of COL7A1 1 0.02 0.08 0.21
109 INT297544 Pou3f3 Regulation of Notch1 1 0.06 0.41 0.2
110 INT92691 Tgfb1 Positive_regulation of Ctgf 1 0.16 0.91 0.2
111 INT342163 Nkx2-1 Regulation of Gene_expression of Aqp1 1 0.06 0.51 0.2
112 INT92692 Tgfb1 Positive_regulation of Gene_expression of Fn1 1 0.27 0.91 0.2
113 INT343547 ROCK1 Positive_regulation of Gene_expression of PTHLH 1 0.15 0.2 0.2
114 INT92693 Tgfb1 Positive_regulation of Fgf2 1 0.32 0.9 0.2
115 INT354226 Arc Positive_regulation of Gene_expression of Accn3 1 0.06 0.29 0.2
116 INT354214 Arc Positive_regulation of Gene_expression of Accn1 1 0.01 0.29 0.2
117 INT355364 Regulation of PTHLH Positive_regulation of Tnfsf11 1 0.04 1.51 0.19
118 INT280260 Tgfb1 Positive_regulation of Cxcr1 1 0.07 1.78 0.19
119 INT280270 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.08 1.81 0.19
120 INT355363 PTHLH Positive_regulation of Tnfsf11 1 0.04 1.47 0.19
121 INT92694 Tgfb1 Positive_regulation of Positive_regulation of Col3a1 1 0.31 0.89 0.19
122 INT280275 Tgfb1 Positive_regulation of VEGFA 1 0.02 2.46 0.19
123 INT153457 Tgfb1 Positive_regulation of Gene_expression of Ctgf 1 0.13 1.15 0.19
124 INT280268 Tgfb1 Positive_regulation of Gene_expression of Vegfa 1 0.06 1.81 0.19
125 INT259814 Binding of Arc and Egr1 1 0.34 0.55 0.19
126 INT280266 Tgfb1 Positive_regulation of Vegfa 1 0.09 1.8 0.19
127 INT259813 Binding of Egr1 and Arc 1 0.32 0.55 0.19
128 INT280261 Tgfb1 Positive_regulation of Gene_expression of Cxcr1 1 0.05 1.81 0.19
129 INT280267 Tgfb1 Positive_regulation of Cxcr4 1 0.11 2.45 0.19
130 INT280274 Tgfb1 Positive_regulation of Gene_expression of VEGFA 1 0.02 2.58 0.19
131 INT350718 Mir106b Regulation of TGFB1 1 0.00 0.42 0.18
132 INT350603 MIR25 Regulation of TGFB1 1 0.01 0.42 0.18
133 INT111152 Pthlh Positive_regulation of Localization of Avp 1 0.53 0.26 0.18
134 INT271451 TGFB1 Regulation of Serpine1 1 0.00 0.68 0.18
135 INT224680 Tgfb1 Negative_regulation of Pten 1 0.00 1.19 0.18
136 INT333449 Binding of SMAD2 and SMAD4 1 0.23 0 0.17
137 INT85334 Agtr2 Regulation of Regulation of Tgfb1 1 0.23 0.68 0.17
138 INT346519 Binding of PTHLH and TFIP11 1 0.09 0.12 0.17
139 INT296037 TGFB1 Positive_regulation of IL17A 1 0.02 0 0.17
140 INT333447 Binding of SMAD2 and RXRA 1 0.04 0 0.16
141 INT160083 TGFB1 Positive_regulation of Gene_expression of L1CAM 1 0.16 1.53 0.16
142 INT316052 Notch1 Regulation of Binding of Cd8a 1 0.01 0.86 0.15
143 INT316053 Notch1 Regulation of Binding of Cd4 1 0.02 0.86 0.15
144 INT316050 Binding of Notch1 and Regulation of Binding of Cd8a 1 0.01 0.86 0.15
145 INT85333 Aqp1 Positive_regulation of Negative_regulation of Tgfb1 1 0.25 0.67 0.15
146 INT316051 Binding of Notch1 and Regulation of Binding of Cd4 1 0.02 0.86 0.15
147 INT107889 Binding of Pthlh and Pth1r 1 0.06 0 0.14
148 INT239323 Binding of Nr1h2 and Positive_regulation of Positive_regulation of Tgfb1 1 0.00 3.71 0.14
149 INT299550 TGFB1 Negative_regulation of Glul 1 0.01 0.34 0.14
150 INT107892 Binding of Pthlh and PTH2 1 0.27 0 0.14
151 INT254855 Agt Positive_regulation of Tgfb1 1 0.03 0.18 0.13
152 INT296031 Negative_regulation of TGFB1 Regulation of IL10 1 0.01 1.01 0.13
153 INT296027 TGFB1 Regulation of TH1L 1 0.02 1 0.13
154 INT299547 Negative_regulation of Binding of TGFB1 and Egf 1 0.02 0.1 0.13
155 INT69687 Tgfb1 Positive_regulation of Gene_expression of Il4 1 0.23 0 0.12
156 INT200326 Hdac1 Negative_regulation of Lhcgr 1 0.03 0 0.12
157 INT296080 TGFB1 Regulation of Hand2 1 0.01 1 0.12
158 INT343542 ROCK1 Positive_regulation of Positive_regulation of PTHLH 1 0.21 0 0.12
159 INT200318 Hdac1 Negative_regulation of Transcription of Lhcgr 1 0.03 0 0.12
160 INT200306 Hdac1 Negative_regulation of Rorb 1 0.00 0 0.12
161 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12
162 INT200332 Binding of Rcor2 and Hdac1 1 0.15 0.3 0.12
163 INT172976 Mras Regulation of Gene_expression of Smad4 1 0.00 0.83 0.12
164 INT296028 TGFB1 Regulation of IL10 1 0.01 1 0.12
165 INT69688 Tgfb1 Positive_regulation of Rel 1 0.50 0 0.12
166 INT240806 Binding of Glp1r and Arc 1 0.19 0.53 0.11
167 INT296038 TGFB1 Positive_regulation of Gene_expression of IL23R 1 0.02 0.05 0.11
168 INT240805 Positive_regulation of Binding of Glp1r and Arc 1 0.24 0.53 0.11
169 INT299551 Regulation of Binding of TGFB1 and Egf 1 0.03 0.21 0.11
170 INT300313 TGFB1 Positive_regulation of Mapk14 1 0.01 1.5 0.11
171 INT208938 Positive_regulation of Tacr1 Positive_regulation of Nkx2-5 1 0.17 0 0.1
172 INT297546 Neurod1 Regulation of Notch1 1 0.05 0.2 0.1
173 INT259816 Ltp Positive_regulation of Gene_expression of Arc 1 0.03 0.39 0.1
174 INT316823 Sparc Positive_regulation of Phosphorylation of Smad2 1 0.44 0.49 0.1
175 INT293416 IL8 Regulation of PTHLH 1 0.04 1.18 0.1
176 INT293414 HRAS Regulation of PTHLH 1 0.00 1.18 0.1
177 INT269788 Binding of FN1 and TGFB1 1 0.00 0.29 0.1
178 INT192249 Angpt1 Positive_regulation of Localization of NOS3 1 0.01 0.46 0.09
179 INT299555 Lifr Positive_regulation of Gene_expression of TGFB1 1 0.03 0.23 0.09
180 INT278217 Binding of Ciita and Notch1 1 0.41 0.22 0.09
181 INT192248 Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
182 INT192250 Positive_regulation of Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
183 INT116789 Bsg Positive_regulation of Gene_expression of Tgfb1 1 0.00 0.18 0.09
184 INT127143 Binding of IL6 and TGFB1 2 0.01 0.16 0.08
185 INT238628 Mef2c Regulation of Gene_expression of Arc 1 0.09 0.16 0.08
186 INT296041 Binding of TGFB1 and IL21 1 0.01 0.05 0.08
187 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
188 INT134832 TGFB1 Regulation of YAP1 1 0.16 0.68 0.08
189 INT134837 TGFB1 Regulation of SMAD7 1 0.34 0.68 0.08
190 INT342231 Binding of SEPP1 and ARC 1 0.04 3.84 0.08
191 INT208943 Nfkb1 Positive_regulation of Nkx2-5 1 0.11 0.38 0.08
192 INT134833 TGFB1 Regulation of Gene_expression of SMAD7 1 0.34 0.69 0.08
193 INT304330 TGFB1 Positive_regulation of ECM1 1 0.00 0.31 0.08
194 INT251232 Slc17a6 Positive_regulation of Tgfb1 1 0.03 0 0.08
195 INT134835 TGFB1 Regulation of Gene_expression of YAP1 1 0.49 0.69 0.08
196 INT134834 TGFB1 Positive_regulation of YAP1 1 0.55 0.81 0.08
197 INT134838 TGFB1 Positive_regulation of SMAD7 1 0.52 0.79 0.08
198 INT299548 Binding of TGFB1 and Lif 1 0.02 0 0.07
199 INT335890 Binding of Dkk1 and Lrp4 1 0.37 0.64 0.07
200 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07

Single Events

The table below shows the top 100 pain related interactions that have been reported for endoderm development. They are ordered first by their pain relevance and then by number of times they were reported in endoderm development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18
2 INT61873 Gene_expression of Arc 128 0.78 128.25 52.24
3 INT4459 Positive_regulation of Arc 74 0.69 33.61 28.29
4 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76
5 INT73314 Gene_expression of Arc 133 0.78 67.78 27.44
6 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23
7 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2
8 INT12081 Localization of TGFB1 64 0.81 35.4 17.47
9 INT20966 Positive_regulation of Arc 30 0.70 24.38 15.62
10 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53
11 INT121783 Positive_regulation of Gene_expression of Arc 30 0.70 29.22 13.02
12 INT129883 Gene_expression of Dkk1 56 0.77 45.42 12.52
13 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07
14 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85
15 INT119940 Positive_regulation of Gene_expression of Arc 36 0.70 18.87 7.85
16 INT4457 Regulation of Arc 27 0.60 14.96 7.83
17 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93
18 INT12564 Localization of Pthlh 23 0.81 4.37 5.82
19 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65
20 INT48201 Localization of Tgfb1 27 0.59 13.65 5.54
21 INT127112 Phosphorylation of Smad2 19 0.80 11.01 5.36
22 INT48200 Transcription of Tgfb1 13 0.69 3.85 5.24
23 INT67868 Negative_regulation of Gene_expression of Tgfb1 18 0.43 14.27 5.16
24 INT89104 Binding of TGFB1 29 0.44 13.67 5.12
25 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41
26 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37
27 INT111156 Negative_regulation of Dkk1 21 0.58 20.08 4.27
28 INT36335 Localization of Tgfb1 19 0.79 7.06 4.17
29 INT69681 Negative_regulation of Tgfb1 42 0.51 22.28 4
30 INT13416 Positive_regulation of Pthlh 19 0.60 14.78 3.74
31 INT106095 Localization of Arc 17 0.80 7.61 3.74
32 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7
33 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6
34 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54
35 INT51848 Transcription of TGFB1 17 0.69 9.57 3.53
36 INT56300 Negative_regulation of Gene_expression of TGFB1 13 0.41 4.87 3.5
37 INT61875 Negative_regulation of Arc 4 0.34 5.61 3.49
38 INT62360 Positive_regulation of PTHLH 31 0.70 28.23 3.46
39 INT69216 Positive_regulation of Tgfb1 14 0.49 5.84 3.29
40 INT85147 Positive_regulation of Gene_expression of Tgfb1 12 0.46 7.29 3.24
41 INT85149 Negative_regulation of Gene_expression of Tgfb1 11 0.42 4.73 3.19
42 INT81734 Regulation of Gene_expression of Arc 12 0.43 7.77 3.06
43 INT112667 Negative_regulation of Tgfb1 9 0.58 2.72 2.97
44 INT9130 Negative_regulation of TGFB1 16 0.41 12.21 2.92
45 INT37363 Localization of PTHLH 14 0.68 13.23 2.92
46 INT130784 Regulation of Gene_expression of Arc 4 0.54 4.9 2.84
47 INT139872 Regulation of Notch1 14 0.45 7.69 2.82
48 INT48199 Regulation of Tgfb1 17 0.54 9.57 2.74
49 INT101246 Gene_expression of Gata6 6 0.68 3.03 2.68
50 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64
51 INT111153 Positive_regulation of Dkk1 13 0.68 10.56 2.58
52 INT82284 Negative_regulation of Gene_expression of Arc 10 0.41 4.26 2.58
53 INT127113 Positive_regulation of Phosphorylation of Smad2 1 0.68 2.38 2.51
54 INT48198 Binding of Tgfb1 29 0.47 19.59 2.46
55 INT194504 Gene_expression of Smad2 27 0.65 7.45 2.25
56 INT130785 Regulation of Arc 9 0.62 5.56 2.2
57 INT12565 Regulation of Localization of Pthlh 10 0.62 0.71 2.14
58 INT50057 Regulation of Notch1 3 0.39 0.87 2.14
59 INT12086 Regulation of Localization of TGFB1 4 0.43 1.65 2.09
60 INT13075 Binding of NKX2-1 6 0.05 0.12 2.08
61 INT158442 Gene_expression of Nkx2-1 21 0.59 8.47 1.99
62 INT107178 Gene_expression of Smad4 12 0.65 9.85 1.92
63 INT246723 Localization of Arc 10 0.63 7.27 1.92
64 INT30153 Regulation of PTHLH 13 0.58 7.72 1.87
65 INT140036 Positive_regulation of Gene_expression of Notch1 6 0.61 2 1.86
66 INT74824 Positive_regulation of Transcription of TGFB1 6 0.67 2.58 1.84
67 INT52633 Negative_regulation of Notch1 4 0.42 2.99 1.84
68 INT13861 Negative_regulation of Localization of Pthlh 2 0.10 0.08 1.81
69 INT323912 Regulation of ARC 1 0.01 1.06 1.78
70 INT101252 Negative_regulation of Gene_expression of Gata6 1 0.51 1.3 1.74
71 INT62071 Positive_regulation of Gene_expression of PTHLH 13 0.70 19.32 1.73
72 INT46530 Gene_expression of Pthlh 15 0.78 11.23 1.7
73 INT101244 Regulation of Gata6 3 0.40 1.52 1.7
74 INT282317 Negative_regulation of Gene_expression of Arc 4 0.37 6.87 1.68
75 INT12566 Positive_regulation of Localization of Pthlh 4 0.70 0.13 1.65
76 INT86712 Regulation of Gene_expression of Tgfb1 2 0.15 2.03 1.65
77 INT84310 Regulation of Gene_expression of Tgfb1 7 0.29 6.6 1.63
78 INT344978 Negative_regulation of Gene_expression of Dkk1 1 0.58 4.38 1.59
79 INT89865 Gene_expression of Nkx2-5 14 0.75 2.99 1.58
80 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57
81 INT4458 Positive_regulation of Positive_regulation of Arc 5 0.49 2.19 1.55
82 INT120071 Negative_regulation of Positive_regulation of Tgfb1 4 0.16 4.06 1.55
83 INT127115 Regulation of Phosphorylation of Smad2 1 0.60 1.74 1.53
84 INT163381 Transcription of Notch1 2 0.69 0.41 1.52
85 INT72329 Transcription of Arc 20 0.67 12.52 1.51
86 INT110992 Positive_regulation of Positive_regulation of TGFB1 4 0.50 3.01 1.51
87 INT72138 Gene_expression of Pthlh 18 0.75 17.68 1.49
88 INT255251 Negative_regulation of Smad2 12 0.32 5.69 1.44
89 INT321889 Negative_regulation of Dkk1 2 0.38 5.7 1.42
90 INT228040 Negative_regulation of Transcription of Tgfb1 1 0.04 0.49 1.42
91 INT12085 Positive_regulation of Localization of TGFB1 7 0.42 4.9 1.4
92 INT129619 Phosphorylation of Smad2 34 0.61 11.6 1.34
93 INT130098 Negative_regulation of NOTCH1 11 0.42 5.45 1.33
94 INT110784 Protein_catabolism of Notch1 8 0.21 2.32 1.31
95 INT173892 Phosphorylation of TGFB1 8 0.79 2.63 1.3
96 INT178494 Gene_expression of Angpt1 10 0.37 9.77 1.28
97 INT149295 Regulation of NOTCH1 10 0.13 4.26 1.22
98 INT110780 Localization of Notch1 2 0.06 0.47 1.19
99 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14
100 INT78266 Localization of NKX2-1 2 0.73 0.16 1.12
101 INT123727 Negative_regulation of Notch1 6 0.21 1.22 1.11
102 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
103 INT165338 Binding of Dkk1 4 0.37 3.64 1.04
104 INT120858 Positive_regulation of Localization of Tgfb1 7 0.68 1.46 1.03
105 INT15040 Gene_expression of NKX2-1 8 0.65 3.95 1.02
106 INT161716 Localization of Nkx2-5 2 0.74 2.17 1.02
107 INT32760 Regulation of Gene_expression of PTHLH 4 0.51 6.32 1
108 INT128717 Regulation of Tgfb1 6 0.61 1.94 0.94
109 INT3131 Binding of Arc 5 0.34 2.68 0.94
110 INT6833 Binding of Notch1 4 0.36 0.05 0.94
111 INT123852 Negative_regulation of Positive_regulation of Tgfb1 3 0.28 1.69 0.94
112 INT218696 Negative_regulation of Phosphorylation of Smad2 3 0.42 4.36 0.92
113 INT114824 Binding of PTHLH 12 0.42 9.5 0.9
114 INT13074 Positive_regulation of NKX2-1 4 0.19 0.86 0.87
115 INT139322 Negative_regulation of Negative_regulation of Tgfb1 1 0.53 0 0.86
116 INT62072 Negative_regulation of Gene_expression of PTHLH 3 0.43 4.45 0.85
117 INT101248 Negative_regulation of Gata6 1 0.37 0.83 0.85
118 INT101251 Negative_regulation of Positive_regulation of Gata6 1 0.38 0.83 0.85
119 INT85148 Transcription of Tgfb1 5 0.52 1.91 0.84
120 INT101250 Positive_regulation of Gata6 1 0.41 0.83 0.84
121 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
122 INT102848 Negative_regulation of Localization of Tgfb1 3 0.10 1.81 0.83
123 INT165337 Regulation of Dkk1 3 0.44 2.16 0.83
124 INT101245 Transcription of Gata6 2 0.47 0.85 0.82
125 INT326655 Regulation of Positive_regulation of Arc 1 0.35 1.39 0.81
126 INT267095 Regulation of Gene_expression of Smad2 3 0.44 1.77 0.8
127 INT61874 Negative_regulation of Positive_regulation of Arc 2 0.27 1.16 0.79
128 INT139323 Positive_regulation of Negative_regulation of Tgfb1 1 0.45 0 0.79
129 INT242131 Localization of Dkk1 5 0.79 6 0.76
130 INT291617 Negative_regulation of Transcription of TGFB1 2 0.15 0.61 0.76
131 INT137007 Gene_expression of SMAD2 6 0.75 2.53 0.75
132 INT90790 Regulation of Localization of Tgfb1 2 0.29 0.46 0.75
133 INT72330 Negative_regulation of Arc 6 0.40 3.35 0.73
134 INT344975 Regulation of Gene_expression of Dkk1 1 0.44 3.44 0.73
135 INT265318 Negative_regulation of Gene_expression of Smad2 8 0.26 2.16 0.72
136 INT129882 Positive_regulation of Gene_expression of Dkk1 4 0.69 4.62 0.72
137 INT15039 Negative_regulation of NKX2-1 3 0.21 0 0.72
138 INT106096 Regulation of Localization of Arc 3 0.45 1.79 0.72
139 INT172960 Negative_regulation of Gene_expression of Smad4 7 0.39 5.88 0.71
140 INT269896 Positive_regulation of Gene_expression of Smad2 9 0.40 2.15 0.69
141 INT140037 Positive_regulation of Positive_regulation of Notch1 2 0.22 1.34 0.69
142 INT337046 Positive_regulation of Binding of Tgfb1 1 0.30 1.1 0.69
143 INT121302 Positive_regulation of Localization of Tgfb1 5 0.07 1.91 0.67
144 INT114909 Negative_regulation of Localization of TGFB1 5 0.36 1.37 0.66
145 INT137009 Negative_regulation of Gene_expression of SMAD2 4 0.42 1.76 0.66
146 INT268377 Phosphorylation of SMAD2 7 0.80 0.85 0.65
147 INT302664 Positive_regulation of SMAD2 2 0.49 0.85 0.64
148 INT111891 Regulation of Transcription of Tgfb1 1 0.04 0.68 0.64
149 INT89861 Negative_regulation of Nkx2-5 3 0.19 0.12 0.63
150 INT80452 Positive_regulation of Gene_expression of Pthlh 4 0.40 3.77 0.62
151 INT114910 Negative_regulation of Positive_regulation of TGFB1 3 0.34 0.92 0.6
152 INT6831 Negative_regulation of Binding of Notch1 1 0.27 0 0.6
153 INT136920 Positive_regulation of Gene_expression of NOTCH1 12 0.49 8.25 0.59
154 INT173891 Positive_regulation of Phosphorylation of TGFB1 4 0.49 2 0.59
155 INT138140 Protein_catabolism of Tgfb1 2 0.09 0.87 0.59
156 INT324541 Transcription of Arc 2 0.54 3.34 0.58
157 INT30943 Negative_regulation of Pthlh 3 0.20 2.75 0.56
158 INT89869 Negative_regulation of Gene_expression of Nkx2-5 1 0.41 0 0.56
159 INT110782 Negative_regulation of Localization of Notch1 1 0.03 0.33 0.56
160 INT20967 Positive_regulation of Positive_regulation of Arc 1 0.15 0.26 0.55
161 INT149294 Regulation of Localization of NOTCH1 1 0.10 0.9 0.55
162 INT110785 Positive_regulation of Protein_catabolism of Notch1 1 0.05 0.33 0.55
163 INT103781 Negative_regulation of Smad4 9 0.42 4.42 0.54
164 INT69683 Positive_regulation of Transcription of Tgfb1 1 0.67 0 0.53
165 INT50555 Regulation of Pthlh 3 0.16 2.07 0.52
166 INT158889 Gene_expression of Smad2 5 0.65 1.25 0.51
167 INT149297 Protein_catabolism of NOTCH1 2 0.15 0.87 0.51
168 INT251512 Positive_regulation of Transcription of Arc 5 0.51 1.98 0.5
169 INT81175 Localization of Pthlh 4 0.70 7.64 0.5
170 INT40572 Regulation of Localization of PTHLH 1 0.04 0 0.49
171 INT178812 Binding of ARC 6 0.36 10.75 0.47
172 INT158426 Binding of NOTCH1 10 0.36 7.95 0.45
173 INT71019 Negative_regulation of SMAD4 12 0.42 6.88 0.43
174 INT178813 Gene_expression of ARC 9 0.67 10.78 0.43
175 INT194315 Gene_expression of HNF1B 4 0.49 1.47 0.43
176 INT96909 Regulation of Angpt1 2 0.17 0.37 0.43
177 INT110258 Negative_regulation of PTHLH 6 0.56 5.42 0.39
178 INT178497 Positive_regulation of Gene_expression of Angpt1 4 0.19 3.65 0.39
179 INT140982 Negative_regulation of Gene_expression of Pthlh 1 0.30 0.39 0.39
180 INT117096 Gene_expression of Wnt4 2 0.67 4.68 0.38
181 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
182 INT117564 Gene_expression of SMAD4 12 0.71 8.7 0.37
183 INT196927 Binding of Hdac1 9 0.36 2.31 0.36
184 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
185 INT69680 Positive_regulation of Positive_regulation of Tgfb1 3 0.67 1.04 0.35
186 INT242130 Positive_regulation of Positive_regulation of Dkk1 2 0.49 1.71 0.33
187 INT344976 Positive_regulation of Negative_regulation of Dkk1 1 0.49 1.13 0.33
188 INT181918 Positive_regulation of SMAD3 6 0.35 2.62 0.31
189 INT92100 Binding of Smad4 5 0.31 2.23 0.3
190 INT129908 Positive_regulation of Smad2 5 0.45 2.13 0.3
191 INT82118 Positive_regulation of Pthlh 3 0.47 2.46 0.3
192 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
193 INT344977 Negative_regulation of Localization of Dkk1 2 0.42 2.57 0.3
194 INT137008 Positive_regulation of Gene_expression of SMAD2 2 0.49 0.51 0.3
195 INT258685 Regulation of Gene_expression of Notch1 2 0.40 1.45 0.3
196 INT224877 Positive_regulation of Gene_expression of Smad2 1 0.12 0.16 0.29
197 INT196917 Gene_expression of Hdac1 15 0.71 3.66 0.28
198 INT172978 Negative_regulation of SMAD2 4 0.42 0.89 0.27
199 INT282321 Binding of Arc 4 0.29 1.66 0.25
200 INT208915 Positive_regulation of Nkx2-5 3 0.29 1.02 0.25
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