GO:0007512

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Name adult heart development
Categary Process
Go Slim No
Go Link GO:0007512
Unique Molecular Interactions 116
Total Molecular Interactions 133
Total Single Events 1492
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for adult heart development. They are ordered first by their pain relevance and then by number of times they were reported for adult heart development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT89878 Pdyn Positive_regulation of Gene_expression of Nkx2-5 1 0.35 0 1.29
2 INT221 Chd7 Negative_regulation of Th 1 0.02 0 1.04
3 INT54853 Negative_regulation of Adra1a Positive_regulation of Positive_regulation of Ins1 1 0.18 0.23 1
4 INT54852 Negative_regulation of Adra1a Positive_regulation of Ins1 1 0.18 0.23 0.99
5 INT141276 Negative_regulation of Il18 Negative_regulation of Gene_expression of Hand2 1 0.25 0.8 0.92
6 INT74872 Igh-Dex Positive_regulation of Chd7 1 0.01 0.5 0.89
7 INT128404 Mapk1 Positive_regulation of Phosphorylation of Gja1 1 0.65 0.73 0.73
8 INT222811 Binding of Hand2 and TH1L 4 0.03 8.26 0.69
9 INT89875 Pdyn Positive_regulation of Localization of Myh6 1 0.09 0 0.66
10 INT89877 Pdyn Positive_regulation of Nkx2-5 1 0.11 0 0.64
11 INT144129 Prkce Positive_regulation of Phosphorylation of Gja1 1 0.42 0.48 0.55
12 INT79809 Binding of Agtr1a and Adra1a 1 0.02 0.23 0.53
13 INT144128 Binding of Gja1 and Prkce 1 0.40 0.5 0.52
14 INT144130 Binding of Gja1 and Prkcg 1 0.48 0.5 0.52
15 INT338426 Binding of Hand1 and Hand2 2 0.06 2 0.46
16 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46
17 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46
18 INT47101 Adra1a Regulation of Localization of Gnrhr 1 0.02 0.24 0.44
19 INT305853 Polk Regulation of Gene_expression of Hand2 1 0.12 0.93 0.35
20 INT300751 Binding of IGHE and Hand2 1 0.04 0 0.34
21 INT126531 Adra1a Positive_regulation of Serpine1 1 0.03 0.31 0.34
22 INT44654 Phc1 Negative_regulation of Adra1a 1 0.00 0.4 0.33
23 INT266806 Hand2 Regulation of Gene_expression of IL10 1 0.00 1.23 0.32
24 INT241139 Ighg1 Positive_regulation of Hand2 1 0.06 0.65 0.32
25 INT181435 Binding of Ccr2 and Hand2 1 0.17 1.81 0.32
26 INT181433 Hand2 Regulation of Gene_expression of Ccl2 1 0.12 0.68 0.32
27 INT266804 Hand2 Regulation of Gene_expression of IL13 1 0.00 1.23 0.32
28 INT266805 Hand2 Regulation of Gene_expression of IL4 1 0.00 1.23 0.32
29 INT59326 Binding of Adra1a and Positive_regulation of Binding of Npy 1 0.44 0 0.31
30 INT253073 Il4 Positive_regulation of Hand2 1 0.10 0.59 0.31
31 INT300742 Stat6 Regulation of Hand2 1 0.01 0.06 0.3
32 INT300752 GATA3 Regulation of Hand2 1 0.01 0.06 0.3
33 INT93988 Rab8a Regulation of Hand2 1 0.09 0.78 0.3
34 INT109067 Pdyn Positive_regulation of Gene_expression of NKX2-5 1 0.01 0 0.29
35 INT181442 Ccl2 Positive_regulation of Localization of Hand2 1 0.26 0.63 0.29
36 INT185076 Bpifa2 Positive_regulation of Hand2 1 0.16 0.36 0.28
37 INT278209 Ciita Regulation of Hand2 1 0.36 1.53 0.28
38 INT194821 MAPK1 Regulation of Hand2 1 0.03 1.27 0.28
39 INT278216 Ciita Regulation of Gene_expression of Hand2 1 0.36 1.53 0.28
40 INT246442 Hand2 Positive_regulation of Gene_expression of Cd79a 1 0.03 0.78 0.27
41 INT305849 Polk Positive_regulation of Gene_expression of Hand2 1 0.08 0.76 0.27
42 INT226537 Hand2 Positive_regulation of IL22 1 0.02 0.86 0.26
43 INT148345 Binding of Drd3 and Adra1a 1 0.18 0.12 0.21
44 INT195212 Binding of CCR4 and Hand2 1 0.03 0.46 0.21
45 INT226511 Gene_expression of Il25 Positive_regulation of Gene_expression of Hand2 1 0.01 0.95 0.2
46 INT226514 BTPs Negative_regulation of Gene_expression of Hand2 1 0.03 0.22 0.2
47 INT338767 Positive_regulation of Binding of Hand1 and Hand2 1 0.07 0.5 0.2
48 INT226510 BTPs Negative_regulation of Hand2 1 0.03 0.22 0.2
49 INT175464 Hand2 Positive_regulation of Gene_expression of Sftpd 1 0.19 1.05 0.2
50 INT301083 Binding of BCS1L and MYH7 1 0.36 1.53 0.19
51 INT228737 Rae1 Negative_regulation of Hand2 1 0.08 1.07 0.19
52 INT75148 Binding of ADRA1B and ZNF594 1 0.00 0.16 0.18
53 INT316748 IL18 Positive_regulation of Regulation of Hand2 1 0.14 1.11 0.18
54 INT329843 Il4 Regulation of Hand2 1 0.04 0.87 0.18
55 INT181457 Binding of CCL16 and Hand2 1 0.04 0.92 0.17
56 INT294766 Cerk Regulation of Gene_expression of Hand2 1 0.13 0.32 0.15
57 INT347012 Hand2 Positive_regulation of Il4 1 0.01 0 0.14
58 INT347015 Hand2 Regulation of Cd86 1 0.06 0 0.14
59 INT294764 Binding of Hand2 and Cerk 1 0.17 0.31 0.14
60 INT235546 Stat6 Positive_regulation of Positive_regulation of Hand2 1 0.02 0.9 0.14
61 INT347018 Cd80 Regulation of Hand2 1 0.03 0.05 0.13
62 INT347007 Cd86 Regulation of Hand2 1 0.06 0.05 0.13
63 INT296080 TGFB1 Regulation of Hand2 1 0.01 1 0.12
64 INT294760 Cerk Positive_regulation of Hand2 1 0.23 0.16 0.12
65 INT253077 Prok2 Regulation of Gene_expression of Hand2 1 0.10 0.11 0.12
66 INT294758 Regulation of Cerk Positive_regulation of Hand2 1 0.21 0.16 0.12
67 INT228746 Hspa9 Negative_regulation of Positive_regulation of Hand2 1 0.11 0.31 0.11
68 INT228760 Rae1 Negative_regulation of Positive_regulation of Hand2 1 0.08 0.31 0.11
69 INT175463 Sftpd Negative_regulation of Gene_expression of Hand2 1 0.17 0.96 0.11
70 INT208938 Positive_regulation of Tacr1 Positive_regulation of Nkx2-5 1 0.17 0 0.1
71 INT215245 Binding of Myo1f and Chd7 1 0.00 0.64 0.1
72 INT263495 Hand1 Regulation of Localization of Hand2 1 0.12 0.5 0.09
73 INT263496 Hand2 Regulation of Localization of Hand1 1 0.12 0.5 0.09
74 INT252421 Gja1 Regulation of P2ry1 1 0.00 0.28 0.09
75 INT201349 Binding of Hand2 and Il4 1 0.17 0.67 0.09
76 INT208943 Nfkb1 Positive_regulation of Nkx2-5 1 0.11 0.38 0.08
77 INT286298 Binding of Hand2 and Negative_regulation of Gene_expression of Il12a 1 0.07 0.3 0.07
78 INT278454 CSF2 Regulation of Hand2 1 0.02 0.66 0.05
79 INT278208 Ciita Negative_regulation of Gene_expression of Hand2 1 0.34 0.7 0.05
80 INT208945 Nkx2-5 Positive_regulation of Gene_expression of Nppa 1 0.03 0.33 0.05
81 INT310306 Tlr4 Regulation of Gene_expression of Chd7 1 0.01 0.25 0.04
82 INT347020 Hand2 Regulation of Gene_expression of Cd86 1 0.08 0.19 0.04
83 INT347009 Hand2 Regulation of Gene_expression of Il4 1 0.01 0.19 0.04
84 INT305383 Binding of NKX2-5 and FLNA 1 0.10 0.7 0.04
85 INT327451 HTN1 Positive_regulation of Adra1a 1 0.00 1.36 0.03
86 INT322245 Binding of Hcm and Myh7 1 0.11 1.28 0
87 INT305845 Polk Positive_regulation of Regulation of Hand2 1 0.08 0.34 0
88 INT268331 Binding of SNRNP70 and CHD7 1 0.01 1.91 0
89 INT303342 Binding of NPAT and TCAP 1 0.40 0 0
90 INT184137 Binding of Socs5 and Regulation of Hand2 1 0.09 1.01 0
91 INT303404 Binding of TCAP and Jag1 1 0.39 0 0
92 INT230712 Binding of Mnat1 and Ccnh 1 0.34 0.09 0
93 INT269206 Bmca Regulation of Gene_expression of Chd7 1 0.00 0.31 0
94 INT272520 Gene_expression of Dmpk Positive_regulation of Positive_regulation of Nkx2-5 1 0.02 0.43 0
95 INT323332 Binding of Ighm and Chd7 1 0.02 0 0
96 INT339980 Binding of MEF2D and HDAC7 1 0.19 0.78 0
97 INT272521 Binding of DMPK and Nkx2-5 1 0.01 0.42 0
98 INT305847 Polk Positive_regulation of Hand2 1 0.09 0.34 0
99 INT230709 Binding of Cdk7 and Mnat1 1 0.29 0.09 0
100 INT322257 Binding of Mybpc3 and Myh7 1 0.34 0.43 0
101 INT339981 Binding of NR4A1 and MEF2D 1 0.04 0.79 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for adult heart development. They are ordered first by their pain relevance and then by number of times they were reported in adult heart development. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05
2 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22
3 INT112017 Regulation of Hand2 77 0.36 62.23 18.04
4 INT18658 Regulation of Adra1a 34 0.62 5.69 13.78
5 INT173505 Localization of Hand2 63 0.57 45.32 13.66
6 INT44 Positive_regulation of Adra1a 30 0.68 7.09 12.73
7 INT14124 Negative_regulation of Adra1a 34 0.59 7.48 10.85
8 INT348 Regulation of Adra1a 25 0.45 3.33 10.27
9 INT475 Negative_regulation of Adra1a 28 0.58 7.87 9.83
10 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28
11 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24
12 INT7697 Positive_regulation of Adra1a 22 0.68 2.3 9.16
13 INT39301 Gene_expression of Chd7 50 0.26 27.06 8.13
14 INT1448 Binding of Adra1a 23 0.48 1.41 8.01
15 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01
16 INT87775 Phosphorylation of Gja1 13 0.82 2.75 6.56
17 INT7842 Gene_expression of Adra1a 14 0.67 1.99 6.39
18 INT335 Binding of Adra1a 16 0.36 6.16 6
19 INT94466 Regulation of Gene_expression of Hand2 14 0.28 7.97 4.46
20 INT37912 Negative_regulation of Chd7 10 0.26 5.84 4.46
21 INT87780 Gene_expression of Gja1 22 0.77 5.84 4.24
22 INT156131 Binding of Hand2 14 0.25 10.35 3.99
23 INT29394 Gene_expression of Adra1a 9 0.77 3.62 3.91
24 INT77852 Binding of Chd7 8 0.31 4.1 2.51
25 INT87778 Positive_regulation of Gene_expression of Gja1 6 0.69 1.46 2.14
26 INT15211 Localization of Adra1a 3 0.16 0 2.08
27 INT45 Negative_regulation of Positive_regulation of Adra1a 4 0.43 0.84 1.97
28 INT80798 Positive_regulation of Chd7 16 0.14 7.95 1.95
29 INT87779 Positive_regulation of Gja1 4 0.53 0.9 1.95
30 INT129239 Positive_regulation of Positive_regulation of Hand2 5 0.43 2.81 1.93
31 INT87776 Positive_regulation of Phosphorylation of Gja1 3 0.62 0.71 1.86
32 INT148493 Regulation of Mnat1 2 0.23 0.8 1.86
33 INT89865 Gene_expression of Nkx2-5 14 0.75 2.99 1.58
34 INT29395 Positive_regulation of Gene_expression of Adra1a 2 0.50 1.64 1.57
35 INT100672 Transcription of Hand2 9 0.42 2.84 1.47
36 INT14803 Positive_regulation of Positive_regulation of Adra1a 4 0.35 0.49 1.36
37 INT175452 Negative_regulation of Positive_regulation of Hand2 4 0.21 3.78 1.21
38 INT161716 Localization of Nkx2-5 2 0.74 2.17 1.02
39 INT109075 Positive_regulation of Transcription of NKX2-5 1 0.67 0 1.02
40 INT109074 Transcription of NKX2-5 1 0.69 0 1.01
41 INT134822 Gene_expression of Gja1 18 0.72 4.2 1
42 INT37914 Regulation of Negative_regulation of Chd7 1 0.12 0 1
43 INT235516 Positive_regulation of Localization of Hand2 4 0.36 3.04 0.97
44 INT226419 Negative_regulation of Localization of Hand2 4 0.30 3.17 0.96
45 INT112014 Negative_regulation of Regulation of Hand2 3 0.34 2.07 0.86
46 INT109062 Gene_expression of NKX2-5 7 0.75 3.31 0.82
47 INT87777 Regulation of Gja1 1 0.62 0.76 0.81
48 INT125157 Negative_regulation of Gene_expression of Adra1a 1 0.18 0.54 0.8
49 INT196325 Positive_regulation of Gene_expression of Chd7 7 0.14 4.28 0.76
50 INT143306 Positive_regulation of Gja1 3 0.50 0.42 0.75
51 INT128402 Negative_regulation of Phosphorylation of Gja1 1 0.58 0.73 0.73
52 INT152909 Regulation of Gene_expression of Gja1 1 0.61 0.46 0.69
53 INT271488 Negative_regulation of Negative_regulation of Hand2 3 0.18 2.36 0.67
54 INT6734 Localization of Adra1a 3 0.31 0.25 0.67
55 INT87781 Regulation of Phosphorylation of Gja1 1 0.27 0 0.67
56 INT89870 Localization of Myh6 1 0.26 0 0.65
57 INT89861 Negative_regulation of Nkx2-5 3 0.19 0.12 0.63
58 INT39728 Regulation of TCAP 1 0.00 0 0.61
59 INT132588 Positive_regulation of Negative_regulation of Hand2 1 0.03 0.47 0.58
60 INT18657 Negative_regulation of Binding of Adra1a 2 0.43 0.17 0.56
61 INT89869 Negative_regulation of Gene_expression of Nkx2-5 1 0.41 0 0.56
62 INT56708 Positive_regulation of Positive_regulation of Adra1a 1 0.25 0 0.55
63 INT154837 Regulation of Gja1 2 0.45 1.42 0.53
64 INT13738 Negative_regulation of Positive_regulation of Adra1a 3 0.29 0.08 0.52
65 INT21090 Regulation of Negative_regulation of Adra1a 1 0.18 0.35 0.52
66 INT100698 Regulation of Chd7 6 0.34 1.85 0.49
67 INT134820 Positive_regulation of Gene_expression of Gja1 3 0.64 0.84 0.49
68 INT305390 Negative_regulation of NKX2-5 2 0.37 2.24 0.49
69 INT87774 Binding of Gja1 2 0.48 0.19 0.48
70 INT74864 Negative_regulation of Gene_expression of Chd7 1 0.08 0.34 0.44
71 INT284164 Localization of Chd7 3 0.25 1.32 0.41
72 INT325217 Regulation of Positive_regulation of Hand2 1 0.21 0.32 0.41
73 INT66593 Regulation of Gene_expression of Adra1a 2 0.05 0 0.39
74 INT194745 Regulation of Regulation of Hand2 1 0.03 0.95 0.39
75 INT226424 Negative_regulation of Transcription of Hand2 1 0.08 0.66 0.37
76 INT102164 Positive_regulation of Binding of Adra1a 1 0.35 0.19 0.37
77 INT34162 Regulation of Regulation of Adra1a 1 0.02 0 0.36
78 INT44623 Positive_regulation of Regulation of Adra1a 1 0.04 0.64 0.29
79 INT226394 Regulation of Phosphorylation of Hand2 1 0.05 0.97 0.28
80 INT42351 Regulation of Positive_regulation of Adra1a 1 0.01 0 0.26
81 INT118118 Positive_regulation of Binding of Adra1a 1 0.18 0.3 0.26
82 INT208915 Positive_regulation of Nkx2-5 3 0.29 1.02 0.25
83 INT88003 Gene_expression of MYH7 3 0.57 0.65 0.24
84 INT122590 Transcription of Adra1a 1 0.03 0.73 0.24
85 INT100671 Positive_regulation of Transcription of Hand2 2 0.36 0.81 0.23
86 INT126761 Negative_regulation of Gja1 1 0.33 0.08 0.22
87 INT226390 Phosphorylation of Hand2 1 0.14 0.85 0.22
88 INT263492 Positive_regulation of Regulation of Hand2 3 0.19 4.76 0.21
89 INT305392 Binding of NKX2-5 1 0.22 0.93 0.21
90 INT284147 Positive_regulation of MYH7 1 0.12 0.52 0.21
91 INT117571 Gene_expression of Myh7 5 0.27 1.43 0.2
92 INT39288 Regulation of Binding of Adra1a 1 0.20 0.35 0.2
93 INT74928 Gene_expression of ADRA1B 1 0.04 0 0.18
94 INT284888 Regulation of Transcription of Hand2 1 0.16 0.32 0.18
95 INT208925 Positive_regulation of Localization of Nkx2-5 1 0.21 0.14 0.16
96 INT31927 Positive_regulation of Localization of Adra1a 1 0.10 0.17 0.16
97 INT146415 Regulation of Nkx2-5 3 0.44 0.91 0.13
98 INT155667 Negative_regulation of Gene_expression of Gja1 3 0.42 1.16 0.1
99 INT208922 Transcription of Nkx2-5 2 0.29 0.36 0.1
100 INT323415 Regulation of NKX2-5 1 0.39 0.71 0.1
101 INT208917 Positive_regulation of Transcription of Nkx2-5 1 0.21 0 0.1
102 INT323416 Localization of NKX2-5 1 0.65 1.75 0.1
103 INT208918 Positive_regulation of Gene_expression of Nkx2-5 3 0.23 0.48 0.09
104 INT217952 Negative_regulation of MYH7 2 0.01 1.85 0.09
105 INT74929 Positive_regulation of Gene_expression of ADRA1B 1 0.02 0 0.09
106 INT305387 Positive_regulation of Gene_expression of NKX2-5 1 0.31 0.72 0.07
107 INT100697 Positive_regulation of Positive_regulation of Chd7 1 0.13 0.34 0.06
108 INT125793 Protein_catabolism of Adra1a 1 0.39 0.24 0.05
109 INT217940 Negative_regulation of Gene_expression of MYH7 1 0.01 0.41 0.05
110 INT310293 Regulation of Positive_regulation of Chd7 1 0.04 0.36 0.05
111 INT257689 Negative_regulation of Gja1 1 0.37 0.58 0.05
112 INT228786 Regulation of Gene_expression of Gja1 2 0.29 0.49 0.04
113 INT228802 Negative_regulation of Gene_expression of Gja1 4 0.37 0.87 0.03
114 INT216569 Localization of Gja1 2 0.36 0.35 0.03
115 INT192401 Positive_regulation of Binding of Hand2 1 0.08 0 0.03
116 INT259713 Phosphorylation of MYH7 1 0.74 1.31 0.03
117 INT268334 Positive_regulation of CHD7 1 0.42 0.96 0.03
118 INT268335 Negative_regulation of CHD7 1 0.57 0.84 0.03
119 INT247813 Localization of Gja1 2 0.45 0.47 0
120 INT247793 Regulation of Localization of Gja1 2 0.17 0.47 0
121 INT239989 Gene_expression of Myh6 2 0.55 0 0
122 INT268339 Binding of CHD7 1 0.47 2.77 0
123 INT239982 Positive_regulation of Positive_regulation of Myh6 1 0.46 0 0
124 INT230675 Positive_regulation of Gene_expression of Mnat1 1 0.42 0.24 0
125 INT239981 Positive_regulation of Myh6 1 0.46 0 0
126 INT239986 Regulation of Myh6 1 0.25 0 0
127 INT303380 Protein_catabolism of TCAP 1 0.64 0 0
128 INT321246 Negative_regulation of Positive_regulation of Chd7 1 0.03 0 0
129 INT339987 Binding of MEF2D 1 0.19 0.77 0
130 INT230659 Gene_expression of Mnat1 1 0.56 0.24 0
131 INT268333 Gene_expression of CHD7 1 0.75 1.83 0
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