GO:0007529

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Name establishment of synaptic specificity at neuromuscular junction
Categary Process
Go Slim No
Go Link GO:0007529
Unique Molecular Interactions 85
Total Molecular Interactions 130
Total Single Events 1070
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for establishment of synaptic specificity at neuromuscular junction. They are ordered first by their pain relevance and then by number of times they were reported for establishment of synaptic specificity at neuromuscular junction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT12140 Ngf Regulation of Chat 1 0.44 1.67 2.18
2 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
3 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16
4 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
5 INT338053 F2r Positive_regulation of Localization of Calca 1 0.06 0.47 1.15
6 INT12138 Ins1 Negative_regulation of Chat 1 0.27 0.71 1.01
7 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
8 INT56742 LIF Positive_regulation of Chat 1 0.02 0.2 0.98
9 INT207149 Binding of F2r and Par2 1 0.17 1.64 0.92
10 INT251706 Chat Regulation of Gene_expression of Acot1 1 0.06 1.64 0.85
11 INT251708 Chat Regulation of Acot1 1 0.03 1.64 0.84
12 INT12142 Ins1 Regulation of Chat 1 0.24 0.69 0.84
13 INT18447 Binding of Ache and Chat 2 0.33 0.33 0.73
14 INT68211 Binding of Calca and Chat 1 0.37 0 0.71
15 INT338057 Positive_regulation of F2r Positive_regulation of Localization of Calca 1 0.05 0.28 0.71
16 INT150338 Binding of F2 and F2R 1 0.11 0.4 0.67
17 INT167907 Binding of F2r and ITS 1 0.01 0.7 0.55
18 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
19 INT106346 Mtpn Regulation of Chat 1 0.06 0 0.52
20 INT338038 Gopc Regulation of Gene_expression of F2r 1 0.08 0 0.52
21 INT338045 F2r Regulation of Localization of Calca 1 0.03 0.05 0.52
22 INT205733 Gphn Regulation of Gene_expression of Gabrd 1 0.03 0.18 0.51
23 INT12143 Ngf Positive_regulation of Chat 1 0.45 0.29 0.49
24 INT56736 Cntf Positive_regulation of Chat 1 0.00 0.1 0.49
25 INT56745 CNTF Positive_regulation of Chat 1 0.02 0.1 0.49
26 INT309370 Positive_regulation of Glyr1 Positive_regulation of Positive_regulation of Gphn 1 0.01 0 0.47
27 INT353331 Elane Positive_regulation of F2r 1 0.08 0.78 0.44
28 INT338059 Nrtn Positive_regulation of Gene_expression of F2r 1 0.12 0.45 0.41
29 INT205567 Regulation of Binding of Fgf1 and Chat 1 0.29 0.28 0.41
30 INT205566 Binding of Fgf1 and Chat 1 0.24 0.28 0.41
31 INT61660 Binding of CHAT and CYP21A2 1 0.00 0 0.4
32 INT156237 Binding of F2r and Tnfsf14 1 0.02 1.14 0.4
33 INT353332 Binding of F2r and Pawr 1 0.18 0.67 0.39
34 INT79504 Binding of Gad1 and Chat 1 0.35 0 0.38
35 INT79507 Binding of Pvalb and Chat 1 0.06 0 0.38
36 INT156235 Tnfsf14 Positive_regulation of F2r 1 0.03 1.03 0.35
37 INT353333 Positive_regulation of F2r Positive_regulation of Localization of Mif 1 0.46 0.26 0.32
38 INT353334 F2r Positive_regulation of Mif 1 0.68 0 0.32
39 INT353335 F2r Regulation of Positive_regulation of Mif 1 0.27 0.11 0.31
40 INT191799 PROC Negative_regulation of Binding of F2r 1 0.00 0.92 0.3
41 INT353336 F2r Regulation of Localization of Mif 1 0.23 0.24 0.28
42 INT22722 Binding of Chat and Hc3 1 0.39 0 0.28
43 INT353330 F2r Positive_regulation of Positive_regulation of Mif 1 0.46 0 0.26
44 INT123663 F2R Positive_regulation of MAPK14 1 0.12 0.42 0.26
45 INT123662 Negative_regulation of F2R Positive_regulation of MAPK14 1 0.08 0.42 0.26
46 INT305686 Binding of Gfap and F2r 1 0.01 0 0.25
47 INT191792 Binding of F2r and Serpinc1 1 0.00 3.74 0.24
48 INT123660 F2R Positive_regulation of PAR1 2 0.10 1.96 0.22
49 INT338042 F2r Positive_regulation of Localization of Prkca 1 0.06 0.1 0.2
50 INT222543 Il1a Regulation of Chat 1 0.01 0.64 0.19
51 INT123664 F2R Positive_regulation of PAR4 1 0.03 0.51 0.19
52 INT195115 Gene_expression of Gopc Positive_regulation of Positive_regulation of F2r 1 0.17 1.67 0.18
53 INT195114 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of F2r 1 0.38 1.67 0.18
54 INT207144 F2r Positive_regulation of Pawr 1 0.14 0.51 0.16
55 INT160929 Chat Positive_regulation of Penk 1 0.35 1.18 0.15
56 INT244045 Binding of Arhgef9 and Gphn 1 0.02 0.2 0.15
57 INT207117 Binding of VEGFA and F2r 1 0.02 0.56 0.15
58 INT338040 Ctsg Positive_regulation of F2r 1 0.29 0 0.15
59 INT338052 F2r Positive_regulation of F2rl3 1 0.12 0 0.15
60 INT147863 Binding of CHAT and SLC18A3 1 0.34 0.8 0.14
61 INT347868 Ntf3 Negative_regulation of Negative_regulation of Chat 1 0.03 0.22 0.13
62 INT244059 Binding of Gabarap and Gphn 1 0.05 0.05 0.13
63 INT244013 Gphn Positive_regulation of Gabrg1 1 0.07 0 0.11
64 INT338041 F2r Positive_regulation of Pard3 1 0.15 0.05 0.11
65 INT244039 Binding of Gabrg1 and Gphn 1 0.09 0.16 0.1
66 INT201721 Ngf Regulation of Chat 1 0.02 0.4 0.1
67 INT262255 Binding of APC and F2R 1 0.05 3 0.1
68 INT251710 Fig4 Regulation of Chat 1 0.03 0.23 0.08
69 INT251705 Fig4 Regulation of Localization of Chat 1 0.05 0.23 0.08
70 INT353341 F2r Positive_regulation of Negative_regulation of Mif 1 0.49 0 0.05
71 INT242601 Gdnf Positive_regulation of Chat 1 0.29 0.15 0.03
72 INT261728 PSMB6 Negative_regulation of Transcription of F2R 1 0.01 0.17 0.03
73 INT101159 Gene_expression of Bcl2 Positive_regulation of Gene_expression of CHAT 1 0.31 0.96 0.03
74 INT175628 F2R Positive_regulation of F2RL1 1 0.04 1.46 0.03
75 INT242611 Nrtn Positive_regulation of Chat 1 0.26 0.15 0.03
76 INT261729 COL5A2 Regulation of Gene_expression of F2R 1 0.18 0 0
77 INT261732 F2 Positive_regulation of F2R 1 0.14 0 0
78 INT338047 Binding of F2r and Pard3 1 0.11 0 0
79 INT142143 F2r Regulation of Plcg1 1 0.02 0.07 0
80 INT261730 ROCK1 Positive_regulation of Positive_regulation of F2R 1 0.37 0 0
81 INT356253 Binding of CLTC and Gphn 1 0.00 0 0
82 INT142142 F2r Positive_regulation of Phosphorylation of Plcg1 1 0.03 0.08 0
83 INT353337 F2r Positive_regulation of Gene_expression of Mif 1 0.46 0 0
84 INT261735 Positive_regulation of F2 Positive_regulation of F2R 1 0.14 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for establishment of synaptic specificity at neuromuscular junction. They are ordered first by their pain relevance and then by number of times they were reported in establishment of synaptic specificity at neuromuscular junction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT118512 Gene_expression of F2r 33 0.63 26.56 18.26
2 INT6381 Negative_regulation of Chat 51 0.59 19.68 15.86
3 INT4851 Positive_regulation of Chat 53 0.70 9.21 15.11
4 INT16266 Gene_expression of Chat 80 0.67 16.14 15.01
5 INT11945 Regulation of Chat 38 0.62 7.75 14.97
6 INT4736 Gene_expression of Chat 67 0.77 17.15 14.24
7 INT41728 Gene_expression of CHAT 65 0.75 42.19 12.73
8 INT15308 Localization of Chat 29 0.81 2.35 8.47
9 INT15592 Positive_regulation of F2r 17 0.67 8.66 8.36
10 INT63852 Gene_expression of Gphn 21 0.63 5.64 8.2
11 INT117497 Positive_regulation of F2r 18 0.57 14.45 8.13
12 INT42312 Negative_regulation of Chat 14 0.54 6.13 5.44
13 INT90852 Gene_expression of F2r 26 0.78 5.5 4.66
14 INT48449 Regulation of Chat 11 0.61 4.24 3.64
15 INT46754 Localization of F2r 7 0.78 2.36 3.24
16 INT58433 Negative_regulation of F2r 9 0.59 2.77 3.08
17 INT94688 Negative_regulation of Gphn 4 0.21 2.35 2.95
18 INT82653 Regulation of F2r 8 0.36 3.78 2.62
19 INT47386 Negative_regulation of CHAT 5 0.29 1.63 2.61
20 INT89830 Positive_regulation of Gphn 4 0.45 0.81 2.61
21 INT150339 Gene_expression of F2R 10 0.73 3.59 2.46
22 INT11943 Transcription of Chat 10 0.70 1.55 2.36
23 INT82652 Negative_regulation of F2r 4 0.37 3.5 2.19
24 INT22282 Positive_regulation of Chat 8 0.67 2.82 2.12
25 INT87374 Positive_regulation of CHAT 7 0.67 3.91 1.96
26 INT222970 Localization of Chat 6 0.73 0.96 1.66
27 INT156231 Binding of F2r 9 0.23 3.78 1.57
28 INT222971 Negative_regulation of Negative_regulation of Chat 1 0.38 1.25 1.53
29 INT32900 Negative_regulation of Positive_regulation of Chat 3 0.43 1.91 1.45
30 INT242532 Positive_regulation of Gene_expression of Chat 14 0.50 2.38 1.44
31 INT58452 Positive_regulation of Negative_regulation of Chat 4 0.50 1.99 1.35
32 INT117498 Regulation of Positive_regulation of F2r 1 0.18 0.91 1.24
33 INT63845 Regulation of Gene_expression of Gphn 5 0.36 0.23 1.23
34 INT98976 Regulation of F2r 7 0.60 0.71 1.22
35 INT338033 Localization of F2r 1 0.41 0.62 1.2
36 INT44621 Binding of Chat 5 0.45 0.87 1.15
37 INT57188 Regulation of Gene_expression of Chat 4 0.45 1.89 1.12
38 INT222968 Negative_regulation of Gene_expression of Chat 8 0.42 1.1 1.1
39 INT243982 Gene_expression of Gphn 13 0.63 1.39 1.09
40 INT227604 Transcription of Chat 4 0.52 1.01 1.08
41 INT57189 Negative_regulation of Gene_expression of Chat 5 0.56 1.35 1.07
42 INT30316 Regulation of CHAT 6 0.43 1.95 0.96
43 INT72990 Binding of Gphn 4 0.25 0.34 0.94
44 INT195105 Negative_regulation of Gene_expression of F2r 3 0.37 1.41 0.91
45 INT56200 Negative_regulation of Negative_regulation of Chat 3 0.25 1.38 0.88
46 INT193070 Localization of CHAT 3 0.17 1.03 0.86
47 INT243977 Positive_regulation of Gene_expression of Gphn 3 0.41 0.11 0.83
48 INT72992 Transcription of Gphn 3 0.50 0.19 0.8
49 INT195099 Positive_regulation of Gene_expression of F2r 7 0.57 5.31 0.78
50 INT353325 Positive_regulation of Localization of F2r 1 0.49 1.31 0.76
51 INT62192 Regulation of Localization of F2r 2 0.60 0.59 0.7
52 INT100626 Transcription of CHAT 4 0.51 1.94 0.69
53 INT44622 Positive_regulation of Binding of Chat 3 0.39 0.71 0.68
54 INT88188 Negative_regulation of Transcription of Chat 1 0.51 0 0.68
55 INT242541 Regulation of Gene_expression of Chat 3 0.43 0.67 0.67
56 INT99750 Localization of Gphn 2 0.73 1.28 0.63
57 INT207089 Regulation of Negative_regulation of F2r 1 0.17 1.49 0.62
58 INT353321 Regulation of Positive_regulation of F2r 1 0.60 0.6 0.62
59 INT123672 Positive_regulation of F2R 9 0.47 0.77 0.58
60 INT191777 Binding of F2r 2 0.02 0.89 0.54
61 INT11942 Positive_regulation of Transcription of Chat 2 0.47 0.23 0.54
62 INT243949 Positive_regulation of Gphn 3 0.41 0.29 0.52
63 INT338026 Regulation of Localization of F2r 1 0.25 0.05 0.52
64 INT106973 Positive_regulation of Gene_expression of CHAT 3 0.44 0.8 0.5
65 INT196398 Protein_catabolism of Chat 1 0.24 2.1 0.47
66 INT89829 Positive_regulation of Positive_regulation of Gphn 1 0.00 0.29 0.47
67 INT309338 Positive_regulation of Positive_regulation of Gphn 1 0.09 0 0.44
68 INT85761 Positive_regulation of Gene_expression of Chat 5 0.30 1.43 0.39
69 INT72991 Regulation of Gphn 4 0.22 0.34 0.38
70 INT144981 Binding of F2R 3 0.36 1.66 0.35
71 INT243956 Negative_regulation of Gphn 3 0.35 0.94 0.35
72 INT353324 Negative_regulation of Positive_regulation of F2r 1 0.41 0.24 0.35
73 INT87388 Negative_regulation of Positive_regulation of CHAT 1 0.42 0.41 0.34
74 INT95831 Regulation of Negative_regulation of Chat 1 0.09 0 0.32
75 INT215979 Binding of Gphn 4 0.34 0.77 0.26
76 INT62191 Negative_regulation of Localization of F2r 1 0.35 0 0.26
77 INT195091 Negative_regulation of Positive_regulation of F2r 1 0.48 1.69 0.25
78 INT109433 Phosphorylation of Chat 1 0.15 0.65 0.24
79 INT218031 Regulation of Transcription of CHAT 1 0.27 0 0.24
80 INT305682 Positive_regulation of Positive_regulation of F2r 1 0.03 0 0.24
81 INT72994 Localization of Gphn 2 0.51 0 0.23
82 INT320581 Positive_regulation of Gene_expression of Gphn 1 0.34 0 0.23
83 INT297457 Regulation of Regulation of Chat 1 0.27 0.32 0.21
84 INT195112 Positive_regulation of Positive_regulation of F2r 1 0.41 0.97 0.18
85 INT261745 Regulation of F2R 1 0.43 0.22 0.16
86 INT261739 Regulation of Gene_expression of F2R 1 0.26 0.22 0.16
87 INT98700 Regulation of Gene_expression of F2r 1 0.45 0 0.15
88 INT314791 Binding of Chat 1 0.32 0 0.15
89 INT207087 Negative_regulation of Binding of F2r 1 0.27 0.06 0.14
90 INT243962 Negative_regulation of Gene_expression of Gphn 1 0.13 0.13 0.12
91 INT323950 Phosphorylation of Chat 1 0.09 0.93 0.11
92 INT72993 Regulation of Localization of Gphn 1 0.09 0 0.11
93 INT311132 Regulation of Regulation of Gphn 1 0.22 0.34 0.11
94 INT297461 Protein_catabolism of Chat 1 0.39 0.5 0.1
95 INT307530 Negative_regulation of Binding of F2R 1 0.03 0 0.09
96 INT283601 Negative_regulation of Localization of Gphn 1 0.30 0.33 0.08
97 INT145503 Protein_catabolism of F2r 1 0.66 0.46 0.07
98 INT195082 Regulation of Gene_expression of F2r 1 0.37 0.67 0.07
99 INT227603 Negative_regulation of Localization of Chat 1 0.12 0 0.07
100 INT261737 Transcription of F2R 1 0.50 0.31 0.05
101 INT159025 Negative_regulation of Localization of Chat 1 0.39 0 0.04
102 INT283603 Regulation of Gene_expression of Gphn 1 0.37 0.17 0.04
103 INT226593 Positive_regulation of Positive_regulation of Chat 1 0.20 0.65 0.04
104 INT353327 Transcription of F2r 1 0.67 0.21 0.03
105 INT191771 Positive_regulation of Gene_expression of F2r 1 0.01 0.31 0.03
106 INT338031 Transcription of F2r 1 0.39 0 0
107 INT283605 Positive_regulation of Binding of Gphn 1 0.36 0.17 0
108 INT227602 Negative_regulation of Transcription of Chat 1 0.12 0.18 0
109 INT314792 Positive_regulation of Localization of Chat 1 0.43 0 0
110 INT353323 Negative_regulation of Gene_expression of F2r 1 0.41 0 0
111 INT261741 Negative_regulation of Positive_regulation of F2R 1 0.40 0 0
112 INT261743 Positive_regulation of Positive_regulation of F2R 1 0.44 0 0
113 INT169264 Regulation of Localization of Chat 1 0.21 0.08 0
114 INT283606 Regulation of Gphn 1 0.44 0.13 0
115 INT283599 Positive_regulation of Localization of Gphn 1 0.41 0.05 0
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